{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3000-s1", "verdict_number": "3000", "title": "Wall-sit training × diastolic pressure: key null result, 4-week signal and gaps", "view_version": "1.0", "view_created_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Cohen has 77 untreated adults aged 35–65 with hypertension, all completed. Decaux has a separate 30 participants; detailed eligibility, blood-pressure medication, comorbidities and age are unverified. The reports are not certified as the same population or used to fill arm-specific analysis denominators for each pressure measure.", "intervention": "Knee angle, intensity calibration and supervision belong to original supervised isometric wall-squat/wall-sit conditions. Report-specific actual delivery, adherence and cointerventions are unverified. Research identification context is not turned into personal exercise, breathing, medication-change or treatment instructions.", "dose": "Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose.", "comparator": "Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. Arm denominators, intensity, contact, expectations and models for each DBP contrast are unverified. Handgrip is not relabeled sham, nor is one effect assigned to all comparators. Direct medication comparisons were not tested.", "endpoint": "The selection is resting DBP. The key 12-week between-group result is null; exact DBP values, effects/CIs/P are unverified. Distinguish separate 4-week DBP -4.6±5.0 mmHg/P<.05 versus controls from SBP -15.2±9.2. The ± is not a between-group 95% CI and its definition is unverified. Within-group SBP -12.9/P<.001, -0.4 and historical simple -12.5 are not DBP effects.", "duration": "Distinguish key initial 12-week training and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold. DBP maintenance, post-training and long-term effects, and the acute study bibliography, population and denominators are unverified. Do not extend this to pressure in other settings, medication replacement or cardiovascular events.", "excluded_extensions": [ "Transferring key null DBP into an effect of 0/equivalence or a small supportive result into independent confirmation under the same conditions", "Transferring within-group SBP changes/P, historical simple differences or ± into between-group DBP effects/95% CIs", "Transferring later once-weekly maintenance into a minimum starting dose", "Combining resting SBP, DBP and acute in-exercise pressure as one result", "Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention", "Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals", "Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification", "Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions" ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which diastolic-pressure claim is selected?", "needed": "Exact subclaim, original grade/note and parent verdict", "role": "Required", "role_reason": "This condition connects Exact subclaim, original grade/note and parent verdict with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Exact subclaim, original grade/note and parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The selection is improved diastolic pressure. Preserve original subclaim D and the note that the key between-group result was null. Absent subclaim score/status differ from parent grade C with 54 points.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original DBP definitions, times and comparisons are needed. Do not fill subclaim values with the parent score." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "What is the key trial’s between-group DBP result?", "needed": "Direct between-group 12-week resting DBP", "role": "Required", "role_reason": "This condition connects Direct between-group 12-week resting DBP with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Direct between-group 12-week resting DBP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Cohen records null between-group DBP alongside SBP. Exact arm DBP values, effects, CIs and P are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm values, adjusted effects, 95% CIs, exact P and analysis tables are needed. Null does not establish an effect of 0 or equivalence." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What does the small sham trial record for DBP?", "needed": "4-week DBP changes versus low-intensity sham/no exercise", "role": "Required", "role_reason": "This condition connects 4-week DBP changes versus low-intensity sham/no exercise with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for 4-week DBP changes versus low-intensity sham/no exercise must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI. This records needed materials; no new research was executed.", "current_reports": [ "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The 30-participant Decaux trial records 4-week DBP -4.6±5.0 mmHg and P<.05 versus controls. SBP -15.2±9.2 is a separate endpoint.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Estimand, ± definition, comparator-specific effects/CIs/P and arm denominators are needed. Do not convert ±5.0 into a between-group 95% CI." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are the key null and small supportive results the same?", "needed": "Report-specific DBP directions, designs and durations", "role": "Required", "role_reason": "This condition connects Report-specific DBP directions, designs and durations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Report-specific DBP directions, designs and durations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Key 12-week between-group DBP is null; the separate 4-week sham trial records a decrease. Parent records no strict R2 upgrade because protocols, funding and prospective primary confirmation differed.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Effects, designs/populations, denominators and prospective status for each contrast are needed. Create no pooled effect, independent-replication certification or grade change." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "In what setting was resting DBP measured?", "needed": "Office versus ambulatory/home pressure", "role": "Required", "role_reason": "This condition connects Office versus ambulatory/home pressure with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Office versus ambulatory/home pressure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The key endpoint is 12-week office resting pressure and maintenance; Decaux has 4-week resting SBP/DBP. 24-hour, daytime, nighttime and home DBP values are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Posture, equipment, repeat/averaging rules, assessor, valid denominators and original tables for other settings are needed. Do not transfer office values to other settings." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are within-group/simple SBP differences DBP effects?", "needed": "Pressure measures and within-/between-group effects", "role": "Required", "role_reason": "This condition connects Pressure measures and within-/between-group effects with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Pressure measures and within-/between-group effects must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent -12.9/P<.001, -0.4 and simple -12.5 mmHg are SBP records. -12.5 is not an adjusted estimate; these values/P are not transferred to DBP.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "DBP-specific tables and direct between-group effects/CIs are needed. Preserve the SBP simple difference as historical; calculate nothing new." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is DBP precision verified?", "needed": "Analysis unit, effects, intervals and exact tests", "role": "Required", "role_reason": "This condition connects Analysis unit, effects, intervals and exact tests with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Analysis unit, effects, intervals and exact tests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The key report preserves null DBP wording; the small trial preserves -4.6±5.0 and P<.05. Exact comparator-specific CIs/P and the ± definition are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Plans, tables/appendices, models, CIs, variance definitions and missing-data handling are needed. P thresholds or sample size alone do not establish precision." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Are the populations the same?", "needed": "Untreated hypertension versus the separate sham population", "role": "Required", "role_reason": "This condition connects Untreated hypertension versus the separate sham population with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Untreated hypertension versus the separate sham population must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The key population is 77 untreated adults aged 35–65 with hypertension. Decaux has 30 participants; detailed eligibility, medication and comorbidities are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Decaux eligibility, baseline pressure, medication and age, plus Cohen arm baselines, are needed. Do not automatically treat the populations as identical untreated hypertension." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "What are the actual comparators and DBP contrasts?", "needed": "Handgrip, wall sit/no exercise versus low-intensity sham", "role": "Required", "role_reason": "This condition connects Handgrip, wall sit/no exercise versus low-intensity sham with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Handgrip, wall sit/no exercise versus low-intensity sham must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Cohen has 3 handgrip, wall-sit and no-exercise arms; Decaux has wall sit, low-intensity sham and no exercise. P<.05 versus controls does not provide each detailed comparator test.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm allocation, intensity, cointerventions and comparator-specific DBP models/results are needed. Do not relabel handgrip sham or copy one effect to every control." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are initial and maintenance DBP distinguished?", "needed": "Initial/maintenance versus separate short-term results", "role": "Required", "role_reason": "This condition connects Initial/maintenance versus separate short-term results with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Initial/maintenance versus separate short-term results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish initial 12 weeks at 3 times weekly, later maintenance 1 time weekly, and the small 4-week trial. Separate between-group maintenance DBP effects/CIs are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Stage-specific times, denominators, tables and post-training follow-up are needed. Do not extend maintenance to an adequate starting frequency or persistent DBP effects." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are supervision and intensity retained in scope?", "needed": "Supervision, knee angle, intensity and delivery context", "role": "Required", "role_reason": "This condition connects Supervision, knee angle, intensity and delivery context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Supervision, knee angle, intensity and delivery context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Supervised wall sits, knee angle and intensity calibration are parts of the original intervention. This is research identification context, not personal exercise or home-DBP efficacy guidance.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific supervision, intensity, adherence and cointerventions are needed. Create no exercise prescription." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "What are the original DBP denominators?", "needed": "Allocation/completion versus arm DBP analysis denominators", "role": "Required", "role_reason": "This condition connects Allocation/completion versus arm DBP analysis denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Allocation/completion versus arm DBP analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The key trial has all 77 completed; Decaux has 30 participants. Arm DBP analysis denominators, valid values at each time and missing-data handling are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm allocation/completion/analysis flow and populations are needed. Do not reuse overall counts for every arm/endpoint or add report counts." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Is DBP’s prospective endpoint status verified?", "needed": "1st/2nd outcomes, prospective times and multiplicity", "role": "Required", "role_reason": "This condition connects 1st/2nd outcomes, prospective times and multiplicity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for 1st/2nd outcomes, prospective times and multiplicity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent leaves exact between-group 95% CIs and prospective hierarchy unverified. NCT05025202 alone does not establish Decaux DBP as a prospective primary outcome or confirm multiplicity plans.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Dated registration, protocols, SAPs, changes, DBP hierarchy, times and multiplicity plans are needed. External material was not read in this conversion." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Does DBP establish events or medication replacement?", "needed": "Resting DBP versus patient-important outcomes", "role": "Required", "role_reason": "This condition connects Resting DBP versus patient-important outcomes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Resting DBP versus patient-important outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent describes resting pressure as a surrogate and records that medication replacement/cardiovascular events were not tested. The small DBP signal is not transferred to those endpoints.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "DBP clinical-importance thresholds and separate event/medication comparisons are needed. Create no event-prevention or treatment-replacement conclusion." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Are shared reports being counted as new trials?", "needed": "Reports, trials, selected questions and shared samples", "role": "Required", "role_reason": "This condition connects Reports, trials, selected questions and shared samples with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Reports, trials, selected questions and shared samples must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent 3000 and existing subclaims share Cohen/Decaux reports. Report/sheet counts or 77/30 participants are not new independent-trial/participant totals. Unique totals are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report, cohort and analysis-population identity and overlap material are needed. No new unique totals or independent-replication certification are created." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Which materials were actually read?", "needed": "Stored summaries versus external access", "role": "Required", "role_reason": "This condition connects Stored summaries versus external access with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Stored summaries versus external access must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The complete parent stored summary was used. PubMed, PMCID, DOI and NCT are original bibliographic values; external abstracts, full texts, registration and protocols/SAPs are unread.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual originals, appendices and access records are needed. URLs or historical verification do not establish current reading or fulfillment." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Where are bibliographies and registration identifiers recorded?", "needed": "Report-specific bibliography and identifier locations", "role": "Required", "role_reason": "This condition connects Report-specific bibliography and identifier locations with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Report-specific bibliography and identifier locations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Cohen has PMID 36965163, PMCID PMC10085809 and DOI 10.1111/jch.14621; Decaux has PMID 35083878, PMCID PMC8792514, DOI 10.14814/phy2.15112 and NCT05025202. The NCT is in Decaux’s citation; neither evidence summary has a registration field.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original-paper/registration identity, dates and links are needed. Infer no new URL from identifiers or actual registration reading." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "How are both languages and historical checks preserved?", "needed": "Both languages, selected note and historical scope", "role": "Required", "role_reason": "This condition connects Both languages, selected note and historical scope with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Both languages, selected note and historical scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve both languages, the selected claim/note and parent historical key/sham RCT, funding and acute-safety verification wording. This conversion is no new clinical content review or original-source cross-check.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original text, translation and correction review are needed. Historical verification is not a current clinical-review pass." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Are subclaim values distinct from parent grades/axes?", "needed": "Original subclaim grade/note and absent values versus parent context", "role": "Required", "role_reason": "This condition connects Original subclaim grade/note and absent values versus parent context with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Original subclaim grade/note and absent values versus parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve the original subclaim grade/note and absent score/status. Parent grade C with 54 points, caution and B/S/R1/I2/E+/B1/CX are parent context, not a selected DBP score or independence certification.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Selected-question boundary/content review is needed. Do not rescore, revise axes or copy the parent score." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What are the evidence date and correction records?", "needed": "Original date/empty records versus production date", "role": "Required", "role_reason": "This condition connects Original date/empty records versus production date with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Original date/empty records versus production date must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original evidence date 2026-09-07, empty corrections and empty deliberation string. These are not production/review dates or certification of no external corrections.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Current corrections, follow-up material and source history are needed. Do not inject new dates, corrections or verdict values." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are funding, support, employed authors and analysis roles distinct?", "needed": "Report-specific funding and company involvement", "role": "Required", "role_reason": "This condition connects Report-specific funding and company involvement with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Report-specific funding and company involvement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Cohen’s Colombian Ministry of Science/Colciencias support/no-COI declaration and Decaux’s funding information not provided. Product support, company-employed authors and analysis/reporting involvement require separate verification.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original funding, support, affiliations and analysis/publication roles are needed. Missing information is not no company involvement; parent I2 is not newly certified." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Are allocation, blinding and measurement-bias materials verified?", "needed": "Allocation, measurement and selective reporting", "role": "Required", "role_reason": "This condition connects Allocation, measurement and selective reporting with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Allocation, measurement and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Cohen’s multicenter 3-arm randomized design and Decaux’s randomized sham design. Detailed concealment, assessor blinding, equipment, repeats and selective reporting are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Methods, protocols/SAPs, measurements and change history are needed. Design names alone do not establish official appraisal or completed clinical review." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Is delivery context distinct from actual exposure?", "needed": "Intervention identity, adherence and cointerventions", "role": "Required", "role_reason": "This condition connects Intervention identity, adherence and cointerventions with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Intervention identity, adherence and cointerventions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original training, rest, frequency and stage records as identification context. Arm-specific actual adherence, cumulative exposure and concurrent exercise/medication changes are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm exposure, deviations, cointerventions and analysis impact are needed. Create no exposure total, procedure, intensity-calibration method or medication-change instructions." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are acute in-exercise and resting pressure the same?", "needed": "Acute timing and separate-report identity", "role": "Supplementary", "role_reason": "This condition connects Acute timing and separate-report identity with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Acute timing and separate-report identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values. This records needed materials; no new research was executed.", "current_reports": [], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent records mean 196/112 mmHg during a separate acute 90° hold. This differs from longer-term resting results; its bibliography, population and denominators are not separately identified in the current 2 citations.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Acute originals, populations/denominators, times, exposure and resting-result links are needed. Create no long-term harm rate, event-prevention effect or exercise method from acute values." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "What is the scope of 0 reported adverse events?", "needed": "Harm definitions, collection, exposure and arm denominators", "role": "Supplementary", "role_reason": "This condition connects Harm definitions, collection, exposure and arm denominators with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Harm definitions, collection, exposure and arm denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms. This records needed materials; no new research was executed.", "current_reports": [ "R01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent records all 77 key-trial participants completed and 0 reported adverse events. It is a limited supervised sample; definitions, active collection, arm exposures and harm-analysis denominators are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Definitions, collection, exposure/denominators, deviations and severity tables are needed. 0 is not complete safety or no harms." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are long-term/rare harms and post-training effects known?", "needed": "Short-term/maintenance versus long-term harms and clinical boundaries", "role": "Supplementary", "role_reason": "This condition connects Short-term/maintenance versus long-term harms and clinical boundaries with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Short-term/maintenance versus long-term harms and clinical boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish key initial 12-week/maintenance context from the small 4-week trial. Post-training DBP, rare harms, long-term actual events and unsupervised populations are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Long-term follow-up, surveillance, endpoint denominators and matched interventions/populations are needed. Short-term reports or caution status do not create long-term safety/efficacy certification." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Which materials would trigger an update?", "needed": "Original material, conditions, observations and verdict changes", "role": "Required", "role_reason": "This condition connects Original material, conditions, observations and verdict changes with selected resting diastolic pressure, key null versus separate supportive results, and measurement, denominator, duration, comparator, support and harm boundaries.", "application_exception": "Preserve selected subclaim D and the key null between-group note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. A null result does not establish an effect of 0 or equivalence; SBP values are not transferred to DBP. Create no new effects, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Original material, conditions, observations and verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "This is a DBP sheet based on stored material. Review of original material, conditions, denominators, endpoints/times and shared reports can support updates to relevant observations.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "New original material, complete prechange preservation, criteria versions, applied changes and review history are needed. Create no new clinical research, calculation, verdict or exercise/medication/treatment instructions." } ], "reports": [ { "report_id": "R01", "title": "Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621.", "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/", "report_type": "Multicenter three-arm randomized trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report R01; unique counts and independent replication unverified", "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.", "observed_result": "SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null", "result_level": "Key stored report for the selected DBP question. Preserve 77 participants all completed and null between-group 12-week office resting DBP; exact arm DBP values, effects, 95% CIs, P, denominators and prospective hierarchy are unverified. Null does not establish an effect of 0 or equivalence. Original SBP 141.2→128.3 versus 138.9→138.5 mmHg and within-group/simple differences are parent context, not DBP values.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/" } ] }, { "report_id": "R02", "title": "Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202.", "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/", "report_type": "Randomized wall-sit, low-intensity sham, and no-exercise trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report R02; unique counts and independent replication unverified", "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.", "observed_result": "SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls", "result_level": "Preserve separate 30-participant, 4-week wall-sit/low-intensity sham/no-exercise DBP -4.6±5.0 mmHg and P<.05 versus controls. SBP -15.2±9.2 is a separate endpoint. The meaning of ±, arm denominators, exact comparator-specific effects/CIs/P, population and prospective hierarchy are unverified. Do not convert ±5.0 into a 95% CI, or this result into the same 12-week effect or strict independent confirmation.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified", "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety", "Review incomplete": "Awaiting user review", "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation", "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings", "Inaccessible": "Not applied during this preparation because actual access was not tested", "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary", "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation", "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials" }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report." }, "history": [ { "date": "2026-10-16", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-16" }