CHAMGAP
MethodologyVerdictsExplanations (KO)Evidence CheckCitation KitMonitoring

Vigorous stair exercise snacks × six-week cardiorespiratory fitness

Select a review item to see its details.
Required evidence, verification status and materials actually read
ItemAVerification statusBReading scopeCReview itemDCurrent findingsEWhy unverifiedFRequired materials and conditionsGFurther research
1 Partly verified Full text not readStored summary read N01 · Evidence conditionWhich 6-week fitness claim is being checked?Required
The existing subclaim is improved cardiorespiratory fitness over 6 weeks, originally graded C. Its note records between-group P=.003 for VO2peak together with missing exact effects/CIs. Subclaim score, safety and axes are unrecorded and are not filled from parent C50.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Selected subclaim wording, original grade/note and parent context
Material needed: The original selected-subclaim version and claim-boundary/editorial review records. This records needed materials; no new research was executed.
2 Partly verified Full text not readStored summary read N02 · Evidence conditionWho was studied and what was the allocation size?Required
S01 records a 6-week trial in 24 inactive young adults, with 12 stair participants and 12 no-training controls. Completion, endpoint-specific analysis denominators and detailed eligibility are unverified; S02 acute populations are separate.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Eligibility and group-specific allocation, completion and analysis denominators
Material needed: S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators. This records needed materials; no new research was executed.
3 Partly verified Full text not readStored summary read N03 · Evidence conditionWhat was the original 6-week intervention exposure?Required
Original S01 conditions were 60 steps, 3 times daily, separated by 1–4 hours, 3 days weekly for 6 weeks. These identify the research only; they do not establish actual intensity, supervision or adherence and are not exercise instructions.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Research intervention, planned exposure and actual performance
Material needed: S01 intervention specifications, performance records, appendices and actual intensity/supervision materials. This records needed materials; no new research was executed.
4 Partly verified Full text not readStored summary read N04 · Evidence conditionWhat does the no-training comparison represent?Required
S01 used no-training controls. This differs from S02 uninterrupted sitting; ordinary walking, continuous stairs and generic bodyweight exercise are not substituted as identical comparisons. Actual control activity/contact is unverified.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Control activity, contact and expectancy differences
Material needed: S01 control-management, activity-measurement, contact and expectancy-difference records. This records needed materials; no new research was executed.
5 Partly verified Full text not readStored summary read N05 · Evidence conditionIs the randomization process verified?Required
S01 is labeled a randomized no-training controlled trial. This transfers the preserved design label; it does not establish that original sequence generation, concealment or recruitment order were verified.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Allocation generation, concealment and recruitment order
Material needed: S01 original methods, allocation procedures, recruitment order and research plans. This records needed materials; no new research was executed.
6 Unverified Full text not readStored summary read N06 · Evidence conditionDoes an objective fitness endpoint establish blinding?Required
The original account records objective fitness testing as a strength. Objective-endpoint wording alone does not verify assessor or analyst blinding.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Assessor/analyst blinding and test conditions
Material needed: S01 assessor/analyst blinding records and test procedures. This records needed materials; no new research was executed.
7 Partly verified Full text not readStored summary read N07 · Evidence conditionWhat defines VO2peak, its units and test method?Required
The original S01 endpoint is 6-week VO2peak, also recorded in the parent classification. Exact units, procedures and equipment are unverified; glucose AUC or insulin AUC is not transferred into this endpoint.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Endpoint definition, equipment, units and measurement timing
Material needed: S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables. This records needed materials; no new research was executed.
8 Partly verified Full text not readStored summary read N08 · Evidence conditionAre between-group P and approximately 5% wording the same effect?Required
The original account preserves between-group P=.003 for VO2peak alongside approximately 5% improvement. Approximately 5% is not presented as an exact adjusted between-group effect and is not used to fill that missing estimate.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Test target and attribution of described change
Material needed: S01 group-specific original values, changes, between-group analysis tables and attribution of each described value. This records needed materials; no new research was executed.
9 Unverified Full text not readStored summary read N09 · Evidence conditionAre the exact comparative effect and 95% CI available?Required
S01 results and the subclaim note both record missing exact effects/95% CIs. P=.003 alone is not used to create effect size, precision or CIs.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Comparative estimator, effect and uncertainty
Material needed: S01 between-group analysis tables, estimation models, exact effects and direct CIs. This records needed materials; no new research was executed.
10 Unverified Full text not readStored summary read N10 · Evidence conditionIs the practical size of the fitness signal known?Required
The original account records an objective fitness signal in a small sample. Statistical significance alone does not establish personally perceived benefit, disease prevention or clinical importance.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Effect magnitude, measurement error and relevance criteria
Material needed: S01 effect distributions, measurement error and practical/clinical relevance criteria. This records needed materials; no new research was executed.
11 Unverified Full text not readStored summary read N11 · Evidence conditionAre 24 participants the completion/analysis denominator?Required
The original sample size is 24 (12/12). It is not automatically treated as complete 6-week testing for everyone or the ITT analysis denominator.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Allocation, completion, endpoint-specific analysis and missing data
Material needed: S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators. This records needed materials; no new research was executed.
12 Unverified Full text not readStored summary read N12 · Evidence conditionDoes planned exposure equal actual adherence?Required
The original account contains planned stair exposure and the 6-week duration, but actual adherence information is unlinked. Planned exposure is not converted into actual performance by everyone.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Actual performance, discontinuation and exposure variation
Material needed: S01 adherence, discontinuation, exposure-variation and activity-monitoring records. This records needed materials; no new research was executed.
13 Unverified Full text not readStored summary read N13 · Evidence conditionAre concurrent activity and lifestyle changes separated?Required
The selected question is limited to the original distributed stair program. Ordinary walking, continuous stairs and bodyweight exercise snacks are not combined as the same intervention; concurrent activity and lifestyle changes are unverified.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Other exercise, daily activity and group-specific lifestyle changes
Material needed: S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans. This records needed materials; no new research was executed.
14 Unverified Full text not readStored summary read N14 · Evidence conditionAre prespecified endpoints, registration and plans verified?Required
The original S01 evidence row has no nct key and its citation has no registration identifier. Parent primary-endpoint classification is preserved classification, not proof of a prespecified primary endpoint or absence of registration.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Registration, protocols, SAPs and endpoint hierarchy
Material needed: S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy. This records needed materials; no new research was executed.
15 Unverified Full text not readStored summary read N15 · Evidence conditionAre analysis models and multiplicity plans available?Required
Preserved results record between-group P=.003, but test models, adjustment variables and multiplicity plans are unlinked.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Between-group tests, adjustment variables and multiple comparisons
Material needed: S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans. This records needed materials; no new research was executed.
16 Partly verified Full text not readStored summary read N16 · Evidence conditionIs the acute metabolic protocol the same?Required
S02 was an acute crossover comparison of 8 hourly stair bouts lasting 15–30 seconds over 9 hours versus uninterrupted sitting. This differs from S01’s 60 steps, 3 times daily for 6 weeks and is not used as replication of 6-week fitness.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Separating 6-week training from acute exposure, comparator and duration
Material needed: S02 complete intervention, comparator, duration, actual-exposure and endpoint tables. This records needed materials; no new research was executed.
17 Partly verified Full text not readStored summary read N17 · Evidence conditionHow do the two experiments in S02 relate?Required
One S02 report contains two acute crossover experiments, with 12 lean men and 11 overweight/obese participants in separate populations. They are not summed into one participant denominator or a new unique-trial total.
S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Report, experiments and population-specific correspondence
Material needed: S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships. This records needed materials; no new research was executed.
18 Partly verified Full text not readStored summary read N18 · Evidence conditionAre acute insulin/glucose findings fitness effects?Required
S02 overweight-group insulin AUC −16.5%, P=.036, d=.94 and null glucose/triglycerides at P>.31 are acute metabolic findings. They are not converted into 6-week VO2peak effects or improvement in both fitness and glucose.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Separate VO2peak and insulin/glucose AUC outcomes
Material needed: Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans. This records needed materials; no new research was executed.
19 Unverified Full text not readStored summary read N19 · Evidence conditionIs independent replication of the same protocol verified?Required
The original account records a gap in independent same-protocol replication. S02’s different acute protocol/two experiments and shared reports across both sheets are not counted as independent replication of S01; no new certification of absence across all literature is made here.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Study families, the same protocol and outcome relationships
Material needed: Separate same-protocol trials, researchers, cohorts and study-family relationships. This records needed materials; no new research was executed.
20 Unverified Full text not readStored summary read N20 · Evidence conditionDo 6-week findings establish persistence or disease prevention?Required
The selected question concerns 6-week fitness. Preserve the original long-term disease-outcome gap without extending findings into diabetes/cardiovascular-disease prevention or persistent long-term fitness.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Post-training fitness persistence and clinical endpoints
Material needed: Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes. This records needed materials; no new research was executed.
21 Unverified Full text not readStored summary read N21 · Evidence conditionDoes this apply across ages and diseases?Required
The original account records selection of inactive adults able to perform vigorous stair movements. Findings are not generalized into fitness effects or safety across all ages/diseases.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Population-specific direct materials and selection boundaries
Material needed: Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials. This records needed materials; no new research was executed.
22 Partly verified Full text not readStored summary read N22 · Evidence conditionWhat are S01 funding, support and interests?Required
S01 records McMaster internal, CIHR and scholarship support. Public-funding wording does not establish that all product support, author interests or analysis/reporting roles are verified.
S01
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Funding, product support, employee authors and COI
Material needed: S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
23 Unverified Full text not readStored summary read N23 · Evidence conditionIs the S02 support gap separate?Required
S02 support details are unverified. S01 information is not used to fill S02 funding, product support, employee-author or COI details.
S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Report-specific funding, support and interests
Material needed: S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
24 Unverified Full text not readStored summary read N24 · Evidence conditionAre systematic safety materials available?Supplementary
Parent safety status is Caution and the original account records unavailable systematic adverse-event rates. Mentioned stair-fall/high-intensity-exercise risks are not actual incidence rates or safety verdicts for everyone.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Adverse-event collection, exposure, denominators and discontinuation
Material needed: Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials. This records needed materials; no new research was executed.
25 Partly verified Full text not readStored summary read N25 · Evidence conditionAre parent values and historical adjustments separated?Required
Preserve parent C50, B/S/R1/I2/EX/B2/CX, four false flags and empty overrides. The historical provisional C54→C50 adjustment is not a new verdict, completed current content review or a generated subclaim score.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Parent/subclaim original values and verdict history
Material needed: Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks. This records needed materials; no new research was executed.
26 Partly verified Full text not readStored summary read N26 · Evidence conditionAre bilingual wording, dates and corrections distinguished?Required
Preserve original bilingual wording, the fitness/glucose distinction, evidence date 2026-09-07, an empty corrections array and empty deliberation string. The evidence date is not current external-reading/review time; production date 2026-10-06 is also not completed content review.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Selected/parent bilingual wording, historical date and corrections
Material needed: Additional original versions, actual corrections, complete pre-change history and translation/editorial review records. This records needed materials; no new research was executed.
27 Partly verified Full text not readStored summary read N27 · Evidence conditionWhich materials and links were actually read?Required
The parent stored summary/bibliography for S01/S02 was read and transferred. Paper URLs are original preserved links; external abstracts, full texts, registration, protocols, SAPs and COI materials are unread, with access not attempted.
S01 S02
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Stored-summary reading, external unread materials and needed evidence
Material needed: Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations. This records needed materials; no new research was executed.
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27 itemsWhat the statuses mean

Assessment scope

Stored-material review date
Not recorded
Original evidence cut-off
2026-09-07
Scope actually checked
Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean
This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population
Direct fitness report S01 concerns 24 inactive young adults, with 12 assigned to stairs and 12 to no training. Completion, endpoint-specific analysis, exact eligibility/baseline values and applicability to everyone are unverified. S02’s 12 lean men and 11 overweight/obese participants are separate acute populations and are not summed.
Ingredient, formulation and route
S01 records original research conditions of 60-step ascents 3 times daily, separated by 1–4 hours, 3 days weekly for 6 weeks. Actual intensity, supervision and adherence are unlinked. Distinguish S02’s acute 15–30-second, 8-bout, 9-hour exposure; research identification is not turned into exercise instructions.
Dose
Preserve the original 60 steps, 3 times daily, 3 days weekly and 6 weeks as research conditions only. Actual exposure variation, discontinuation, adherence and concurrent activity are unverified. No new step/frequency/time/exposure totals, calories or personal exercise doses are calculated or prescribed.
Comparator
S01 used a no-training comparator. Actual control activity, contact and expectancy differences are unverified. S02’s uninterrupted sitting, ordinary walking, continuous stair exercise and generic bodyweight exercise are not treated as identical comparisons.
Measured outcome
The selected endpoint is 6-week VO2peak. Distinguish between-group P=.003, the approximately 5% improvement description and missing exact effects/95% CIs. Approximately 5% is not an adjusted between-group effect. Units, test procedures, blinding, endpoint hierarchy, models, precision and clinical importance are unverified.
Duration
The selected question concerns 6-week fitness measurement. S02’s 9-hour acute insulin/glucose AUC and post-training fitness persistence/long-term disease outcomes are separate. Preserve the original long-term outcome gap without extending findings to diabetes or cardiovascular-disease prevention.
Questions outside this scope
Generating adjusted between-group effects, 95% CIs or clinical importance from approximately 5% wording or P=.003; Transferring S02 acute insulin/glucose findings into 6-week VO2peak effects or improvement in both fitness and glucose; Summing two experiments in S02, 12 lean/11 overweight participants or shared sheets into participant, unique-trial or independent-replication totals; Inheriting parent C50, B/S/R1/I2/EX/B2/CX or historical C54→C50 adjustment as absent subclaim values or a new verdict; Extending a short-term fitness signal in selected young adults to all ages/diseases, long-term disease prevention or safety; Combining ordinary walking, continuous stairs or bodyweight exercise as the same intervention or generating exposure totals, exercise instructions, medication changes or treatment guidance

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Jenkins EM, Nairn LN, Skelly LE, Little JP, Gibala MJ. Do stair climbing exercise 'snacks' improve cardiorespiratory fitness? Appl Physiol Nutr Metab. 2019;44(6):681-684. PMID: 30649897. DOI: 10.1139/apnm-2018-0675.

PubMed

Material type
Randomized no-training controlled trial
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary
Between-group P=.003; exact effect and 95% CI unverified
Record level
Direct small trial for selected 6-week fitness. Preserve the original 24 participants (12/12) and P=.003. Approximately 5% wording is not an exact adjusted between-group effect; CIs, units, test methods, completion/analysis denominators and prespecified endpoints are unverified. It is not a direct report of reduced glucose or disease prevention.
Study overlap and independent replication
Parent 2996 and the fitness/glucose sheets share the same two reports. S01 concerns 6-week fitness training; S02 contains two acute crossover experiments under a different 9-hour protocol, with 12 lean and 11 overweight/obese participants in separate populations. Reports, sheets, experiments and populations are not summed into new unique-trial, participant or independent-replication totals; confirmed totals, cohort relationships and independence are unverified.
Public availability, access and reading status by material
MaterialPublic availabilityAccess statusActually readNotes
Stored existing review summaryPreserved copy of the complete parent-verdict stored summaryStored summarySummary readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.
External paperOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.
Registration materialOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.
ProtocolOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.
Statistical analysis planOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.
Funding, product-support and COI materialOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified.

S02 · Rafiei H, Omidian K, Myette-Côté É, Little JP. Metabolic Effect of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks. Med Sci Sports Exerc. 2021;53(1):150-158. PMID: 32555024. DOI: 10.1249/MSS.0000000000002431.

PubMed

Material type
One report containing two acute crossover experiments
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary
Overweight-group insulin −16.5%, P=.036; glucose null
Record level
Background from a different acute protocol for the selected fitness question. Distinguish 12 lean men from 11 overweight/obese participants; preserve the original 9 hours, 8 bouts of 15–30 seconds and uninterrupted-sitting comparison. Overweight-group insulin AUC −16.5%/P=.036/d=.94 and null glucose/triglycerides at P>.31 are not 6-week fitness effects.
Study overlap and independent replication
Parent 2996 and the fitness/glucose sheets share the same two reports. S01 concerns 6-week fitness training; S02 contains two acute crossover experiments under a different 9-hour protocol, with 12 lean and 11 overweight/obese participants in separate populations. Reports, sheets, experiments and populations are not summed into new unique-trial, participant or independent-replication totals; confirmed totals, cohort relationships and independence are unverified.
Public availability, access and reading status by material
MaterialPublic availabilityAccess statusActually readNotes
Stored existing review summaryPreserved copy of the complete parent-verdict stored summaryStored summarySummary readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.
External paperOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.
Registration materialOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.
ProtocolOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.
Statistical analysis planOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.
Funding, product-support and COI materialOriginal bibliographic link or needed material; external public availability/access status unverifiedUnread; access not attemptedNot readPreserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status.

Report counts versus independent study counts

Parent 2996 and the fitness/glucose sheets share the same two reports. S01 concerns 6-week fitness training; S02 contains two acute crossover experiments under a different 9-hour protocol, with 12 lean and 11 overweight/obese participants in separate populations. Reports, sheets, experiments and populations are not summed into new unique-trial, participant or independent-replication totals; confirmed totals, cohort relationships and independence are unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which 6-week fitness claim is being checked?
Required materials and conditions
Selected subclaim wording, original grade/note and parent context
Conditions for verification
Material for Selected subclaim wording, original grade/note and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Selected subclaim wording, original grade/note and parent context with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N02 · Who was studied and what was the allocation size?
Required materials and conditions
Eligibility and group-specific allocation, completion and analysis denominators
Conditions for verification
Material for Eligibility and group-specific allocation, completion and analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Eligibility and group-specific allocation, completion and analysis denominators with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N03 · What was the original 6-week intervention exposure?
Required materials and conditions
Research intervention, planned exposure and actual performance
Conditions for verification
Material for Research intervention, planned exposure and actual performance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Research intervention, planned exposure and actual performance with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N04 · What does the no-training comparison represent?
Required materials and conditions
Control activity, contact and expectancy differences
Conditions for verification
Material for Control activity, contact and expectancy differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Control activity, contact and expectancy differences with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N05 · Is the randomization process verified?
Required materials and conditions
Allocation generation, concealment and recruitment order
Conditions for verification
Material for Allocation generation, concealment and recruitment order must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Allocation generation, concealment and recruitment order with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N06 · Does an objective fitness endpoint establish blinding?
Required materials and conditions
Assessor/analyst blinding and test conditions
Conditions for verification
Material for Assessor/analyst blinding and test conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Assessor/analyst blinding and test conditions with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N07 · What defines VO2peak, its units and test method?
Required materials and conditions
Endpoint definition, equipment, units and measurement timing
Conditions for verification
Material for Endpoint definition, equipment, units and measurement timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Endpoint definition, equipment, units and measurement timing with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N08 · Are between-group P and approximately 5% wording the same effect?
Required materials and conditions
Test target and attribution of described change
Conditions for verification
Material for Test target and attribution of described change must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Test target and attribution of described change with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N09 · Are the exact comparative effect and 95% CI available?
Required materials and conditions
Comparative estimator, effect and uncertainty
Conditions for verification
Material for Comparative estimator, effect and uncertainty must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Comparative estimator, effect and uncertainty with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N10 · Is the practical size of the fitness signal known?
Required materials and conditions
Effect magnitude, measurement error and relevance criteria
Conditions for verification
Material for Effect magnitude, measurement error and relevance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Effect magnitude, measurement error and relevance criteria with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N11 · Are 24 participants the completion/analysis denominator?
Required materials and conditions
Allocation, completion, endpoint-specific analysis and missing data
Conditions for verification
Material for Allocation, completion, endpoint-specific analysis and missing data must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Allocation, completion, endpoint-specific analysis and missing data with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N12 · Does planned exposure equal actual adherence?
Required materials and conditions
Actual performance, discontinuation and exposure variation
Conditions for verification
Material for Actual performance, discontinuation and exposure variation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Actual performance, discontinuation and exposure variation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N13 · Are concurrent activity and lifestyle changes separated?
Required materials and conditions
Other exercise, daily activity and group-specific lifestyle changes
Conditions for verification
Material for Other exercise, daily activity and group-specific lifestyle changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Other exercise, daily activity and group-specific lifestyle changes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N14 · Are prespecified endpoints, registration and plans verified?
Required materials and conditions
Registration, protocols, SAPs and endpoint hierarchy
Conditions for verification
Material for Registration, protocols, SAPs and endpoint hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Registration, protocols, SAPs and endpoint hierarchy with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N15 · Are analysis models and multiplicity plans available?
Required materials and conditions
Between-group tests, adjustment variables and multiple comparisons
Conditions for verification
Material for Between-group tests, adjustment variables and multiple comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Between-group tests, adjustment variables and multiple comparisons with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N16 · Is the acute metabolic protocol the same?
Required materials and conditions
Separating 6-week training from acute exposure, comparator and duration
Conditions for verification
Material for Separating 6-week training from acute exposure, comparator and duration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Separating 6-week training from acute exposure, comparator and duration with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N17 · How do the two experiments in S02 relate?
Required materials and conditions
Report, experiments and population-specific correspondence
Conditions for verification
Material for Report, experiments and population-specific correspondence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Report, experiments and population-specific correspondence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N18 · Are acute insulin/glucose findings fitness effects?
Required materials and conditions
Separate VO2peak and insulin/glucose AUC outcomes
Conditions for verification
Material for Separate VO2peak and insulin/glucose AUC outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Separate VO2peak and insulin/glucose AUC outcomes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N19 · Is independent replication of the same protocol verified?
Required materials and conditions
Study families, the same protocol and outcome relationships
Conditions for verification
Material for Study families, the same protocol and outcome relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Study families, the same protocol and outcome relationships with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N20 · Do 6-week findings establish persistence or disease prevention?
Required materials and conditions
Post-training fitness persistence and clinical endpoints
Conditions for verification
Material for Post-training fitness persistence and clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Post-training fitness persistence and clinical endpoints with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N21 · Does this apply across ages and diseases?
Required materials and conditions
Population-specific direct materials and selection boundaries
Conditions for verification
Material for Population-specific direct materials and selection boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Population-specific direct materials and selection boundaries with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N22 · What are S01 funding, support and interests?
Required materials and conditions
Funding, product support, employee authors and COI
Conditions for verification
Material for Funding, product support, employee authors and COI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Funding, product support, employee authors and COI with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N23 · Is the S02 support gap separate?
Required materials and conditions
Report-specific funding, support and interests
Conditions for verification
Material for Report-specific funding, support and interests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Report-specific funding, support and interests with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N24 · Are systematic safety materials available?
Required materials and conditions
Adverse-event collection, exposure, denominators and discontinuation
Conditions for verification
Material for Adverse-event collection, exposure, denominators and discontinuation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Supplementary
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Adverse-event collection, exposure, denominators and discontinuation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N25 · Are parent values and historical adjustments separated?
Required materials and conditions
Parent/subclaim original values and verdict history
Conditions for verification
Material for Parent/subclaim original values and verdict history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Parent/subclaim original values and verdict history with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N26 · Are bilingual wording, dates and corrections distinguished?
Required materials and conditions
Selected/parent bilingual wording, historical date and corrections
Conditions for verification
Material for Selected/parent bilingual wording, historical date and corrections must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Selected/parent bilingual wording, historical date and corrections with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
N27 · Which materials and links were actually read?
Required materials and conditions
Stored-summary reading, external unread materials and needed evidence
Conditions for verification
Material for Stored-summary reading, external unread materials and needed evidence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability
Required
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Why this condition is needed
This condition connects Stored-summary reading, external unread materials and needed evidence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle
Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review
Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle
Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review
Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle
Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review
Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle
Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review
Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle
Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review
Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
What the statuses mean
Met
A state used when required evidence is confirmed after user review. This production does not declare that review complete.
Partly verified
Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified
The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete
User review pending.
Not reported
Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible
Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable
Not used as a substitute for an evidence gap.
Conflicting data
Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions
Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-16 · Public page/material version 1.0

Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which 6-week fitness claim is being checked?

Current findings
The existing subclaim is improved cardiorespiratory fitness over 6 weeks, originally graded C. Its note records between-group P=.003 for VO2peak together with missing exact effects/CIs. Subclaim score, safety and axes are unrecorded and are not filled from parent C50.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
The original selected-subclaim version and claim-boundary/editorial review records.
Required materials and conditions
Selected subclaim wording, original grade/note and parent context
Materials to obtain first
The original selected-subclaim version and claim-boundary/editorial review records.
Further research
Material needed: The original selected-subclaim version and claim-boundary/editorial review records. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Selected subclaim wording, original grade/note and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Selected subclaim wording, original grade/note and parent context with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N02 · Who was studied and what was the allocation size?

Current findings
S01 records a 6-week trial in 24 inactive young adults, with 12 stair participants and 12 no-training controls. Completion, endpoint-specific analysis denominators and detailed eligibility are unverified; S02 acute populations are separate.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators.
Required materials and conditions
Eligibility and group-specific allocation, completion and analysis denominators
Materials to obtain first
S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators.
Further research
Material needed: S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Eligibility and group-specific allocation, completion and analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Eligibility and group-specific allocation, completion and analysis denominators with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N03 · What was the original 6-week intervention exposure?

Current findings
Original S01 conditions were 60 steps, 3 times daily, separated by 1–4 hours, 3 days weekly for 6 weeks. These identify the research only; they do not establish actual intensity, supervision or adherence and are not exercise instructions.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 intervention specifications, performance records, appendices and actual intensity/supervision materials.
Required materials and conditions
Research intervention, planned exposure and actual performance
Materials to obtain first
S01 intervention specifications, performance records, appendices and actual intensity/supervision materials.
Further research
Material needed: S01 intervention specifications, performance records, appendices and actual intensity/supervision materials. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Research intervention, planned exposure and actual performance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Research intervention, planned exposure and actual performance with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N04 · What does the no-training comparison represent?

Current findings
S01 used no-training controls. This differs from S02 uninterrupted sitting; ordinary walking, continuous stairs and generic bodyweight exercise are not substituted as identical comparisons. Actual control activity/contact is unverified.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 control-management, activity-measurement, contact and expectancy-difference records.
Required materials and conditions
Control activity, contact and expectancy differences
Materials to obtain first
S01 control-management, activity-measurement, contact and expectancy-difference records.
Further research
Material needed: S01 control-management, activity-measurement, contact and expectancy-difference records. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Control activity, contact and expectancy differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Control activity, contact and expectancy differences with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N05 · Is the randomization process verified?

Current findings
S01 is labeled a randomized no-training controlled trial. This transfers the preserved design label; it does not establish that original sequence generation, concealment or recruitment order were verified.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 original methods, allocation procedures, recruitment order and research plans.
Required materials and conditions
Allocation generation, concealment and recruitment order
Materials to obtain first
S01 original methods, allocation procedures, recruitment order and research plans.
Further research
Material needed: S01 original methods, allocation procedures, recruitment order and research plans. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Allocation generation, concealment and recruitment order must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Allocation generation, concealment and recruitment order with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N06 · Does an objective fitness endpoint establish blinding?

Current findings
The original account records objective fitness testing as a strength. Objective-endpoint wording alone does not verify assessor or analyst blinding.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 assessor/analyst blinding records and test procedures.
Required materials and conditions
Assessor/analyst blinding and test conditions
Materials to obtain first
S01 assessor/analyst blinding records and test procedures.
Further research
Material needed: S01 assessor/analyst blinding records and test procedures. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Assessor/analyst blinding and test conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Assessor/analyst blinding and test conditions with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N07 · What defines VO2peak, its units and test method?

Current findings
The original S01 endpoint is 6-week VO2peak, also recorded in the parent classification. Exact units, procedures and equipment are unverified; glucose AUC or insulin AUC is not transferred into this endpoint.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables.
Required materials and conditions
Endpoint definition, equipment, units and measurement timing
Materials to obtain first
S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables.
Further research
Material needed: S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Endpoint definition, equipment, units and measurement timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Endpoint definition, equipment, units and measurement timing with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N08 · Are between-group P and approximately 5% wording the same effect?

Current findings
The original account preserves between-group P=.003 for VO2peak alongside approximately 5% improvement. Approximately 5% is not presented as an exact adjusted between-group effect and is not used to fill that missing estimate.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 group-specific original values, changes, between-group analysis tables and attribution of each described value.
Required materials and conditions
Test target and attribution of described change
Materials to obtain first
S01 group-specific original values, changes, between-group analysis tables and attribution of each described value.
Further research
Material needed: S01 group-specific original values, changes, between-group analysis tables and attribution of each described value. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Test target and attribution of described change must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Test target and attribution of described change with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N09 · Are the exact comparative effect and 95% CI available?

Current findings
S01 results and the subclaim note both record missing exact effects/95% CIs. P=.003 alone is not used to create effect size, precision or CIs.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 between-group analysis tables, estimation models, exact effects and direct CIs.
Required materials and conditions
Comparative estimator, effect and uncertainty
Materials to obtain first
S01 between-group analysis tables, estimation models, exact effects and direct CIs.
Further research
Material needed: S01 between-group analysis tables, estimation models, exact effects and direct CIs. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Comparative estimator, effect and uncertainty must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Comparative estimator, effect and uncertainty with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N10 · Is the practical size of the fitness signal known?

Current findings
The original account records an objective fitness signal in a small sample. Statistical significance alone does not establish personally perceived benefit, disease prevention or clinical importance.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 effect distributions, measurement error and practical/clinical relevance criteria.
Required materials and conditions
Effect magnitude, measurement error and relevance criteria
Materials to obtain first
S01 effect distributions, measurement error and practical/clinical relevance criteria.
Further research
Material needed: S01 effect distributions, measurement error and practical/clinical relevance criteria. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Effect magnitude, measurement error and relevance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Effect magnitude, measurement error and relevance criteria with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N11 · Are 24 participants the completion/analysis denominator?

Current findings
The original sample size is 24 (12/12). It is not automatically treated as complete 6-week testing for everyone or the ITT analysis denominator.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators.
Required materials and conditions
Allocation, completion, endpoint-specific analysis and missing data
Materials to obtain first
S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators.
Further research
Material needed: S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Allocation, completion, endpoint-specific analysis and missing data must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Allocation, completion, endpoint-specific analysis and missing data with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N12 · Does planned exposure equal actual adherence?

Current findings
The original account contains planned stair exposure and the 6-week duration, but actual adherence information is unlinked. Planned exposure is not converted into actual performance by everyone.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 adherence, discontinuation, exposure-variation and activity-monitoring records.
Required materials and conditions
Actual performance, discontinuation and exposure variation
Materials to obtain first
S01 adherence, discontinuation, exposure-variation and activity-monitoring records.
Further research
Material needed: S01 adherence, discontinuation, exposure-variation and activity-monitoring records. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Actual performance, discontinuation and exposure variation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Actual performance, discontinuation and exposure variation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N13 · Are concurrent activity and lifestyle changes separated?

Current findings
The selected question is limited to the original distributed stair program. Ordinary walking, continuous stairs and bodyweight exercise snacks are not combined as the same intervention; concurrent activity and lifestyle changes are unverified.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans.
Required materials and conditions
Other exercise, daily activity and group-specific lifestyle changes
Materials to obtain first
S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans.
Further research
Material needed: S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Other exercise, daily activity and group-specific lifestyle changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Other exercise, daily activity and group-specific lifestyle changes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N14 · Are prespecified endpoints, registration and plans verified?

Current findings
The original S01 evidence row has no nct key and its citation has no registration identifier. Parent primary-endpoint classification is preserved classification, not proof of a prespecified primary endpoint or absence of registration.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy.
Required materials and conditions
Registration, protocols, SAPs and endpoint hierarchy
Materials to obtain first
S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy.
Further research
Material needed: S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Registration, protocols, SAPs and endpoint hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Registration, protocols, SAPs and endpoint hierarchy with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N15 · Are analysis models and multiplicity plans available?

Current findings
Preserved results record between-group P=.003, but test models, adjustment variables and multiplicity plans are unlinked.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans.
Required materials and conditions
Between-group tests, adjustment variables and multiple comparisons
Materials to obtain first
S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans.
Further research
Material needed: S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Between-group tests, adjustment variables and multiple comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Between-group tests, adjustment variables and multiple comparisons with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N16 · Is the acute metabolic protocol the same?

Current findings
S02 was an acute crossover comparison of 8 hourly stair bouts lasting 15–30 seconds over 9 hours versus uninterrupted sitting. This differs from S01’s 60 steps, 3 times daily for 6 weeks and is not used as replication of 6-week fitness.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S02 complete intervention, comparator, duration, actual-exposure and endpoint tables.
Required materials and conditions
Separating 6-week training from acute exposure, comparator and duration
Materials to obtain first
S02 complete intervention, comparator, duration, actual-exposure and endpoint tables.
Further research
Material needed: S02 complete intervention, comparator, duration, actual-exposure and endpoint tables. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Separating 6-week training from acute exposure, comparator and duration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Separating 6-week training from acute exposure, comparator and duration with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N17 · How do the two experiments in S02 relate?

Current findings
One S02 report contains two acute crossover experiments, with 12 lean men and 11 overweight/obese participants in separate populations. They are not summed into one participant denominator or a new unique-trial total.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships.
Required materials and conditions
Report, experiments and population-specific correspondence
Materials to obtain first
S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships.
Further research
Material needed: S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Report, experiments and population-specific correspondence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Report, experiments and population-specific correspondence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S02

N18 · Are acute insulin/glucose findings fitness effects?

Current findings
S02 overweight-group insulin AUC −16.5%, P=.036, d=.94 and null glucose/triglycerides at P>.31 are acute metabolic findings. They are not converted into 6-week VO2peak effects or improvement in both fitness and glucose.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans.
Required materials and conditions
Separate VO2peak and insulin/glucose AUC outcomes
Materials to obtain first
Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans.
Further research
Material needed: Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Separate VO2peak and insulin/glucose AUC outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Separate VO2peak and insulin/glucose AUC outcomes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N19 · Is independent replication of the same protocol verified?

Current findings
The original account records a gap in independent same-protocol replication. S02’s different acute protocol/two experiments and shared reports across both sheets are not counted as independent replication of S01; no new certification of absence across all literature is made here.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Separate same-protocol trials, researchers, cohorts and study-family relationships.
Required materials and conditions
Study families, the same protocol and outcome relationships
Materials to obtain first
Separate same-protocol trials, researchers, cohorts and study-family relationships.
Further research
Material needed: Separate same-protocol trials, researchers, cohorts and study-family relationships. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Study families, the same protocol and outcome relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Study families, the same protocol and outcome relationships with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N20 · Do 6-week findings establish persistence or disease prevention?

Current findings
The selected question concerns 6-week fitness. Preserve the original long-term disease-outcome gap without extending findings into diabetes/cardiovascular-disease prevention or persistent long-term fitness.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes.
Required materials and conditions
Post-training fitness persistence and clinical endpoints
Materials to obtain first
Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes.
Further research
Material needed: Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Post-training fitness persistence and clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Post-training fitness persistence and clinical endpoints with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N21 · Does this apply across ages and diseases?

Current findings
The original account records selection of inactive adults able to perform vigorous stair movements. Findings are not generalized into fitness effects or safety across all ages/diseases.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials.
Required materials and conditions
Population-specific direct materials and selection boundaries
Materials to obtain first
Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials.
Further research
Material needed: Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Population-specific direct materials and selection boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Population-specific direct materials and selection boundaries with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N22 · What are S01 funding, support and interests?

Current findings
S01 records McMaster internal, CIHR and scholarship support. Public-funding wording does not establish that all product support, author interests or analysis/reporting roles are verified.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
Required materials and conditions
Funding, product support, employee authors and COI
Materials to obtain first
S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
Further research
Material needed: S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Funding, product support, employee authors and COI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Funding, product support, employee authors and COI with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N23 · Is the S02 support gap separate?

Current findings
S02 support details are unverified. S01 information is not used to fill S02 funding, product support, employee-author or COI details.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
Required materials and conditions
Report-specific funding, support and interests
Materials to obtain first
S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
Further research
Material needed: S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Report-specific funding, support and interests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Report-specific funding, support and interests with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S02

N24 · Are systematic safety materials available?

Current findings
Parent safety status is Caution and the original account records unavailable systematic adverse-event rates. Mentioned stair-fall/high-intensity-exercise risks are not actual incidence rates or safety verdicts for everyone.
Verification status
Unverified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials.
Required materials and conditions
Adverse-event collection, exposure, denominators and discontinuation
Materials to obtain first
Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials.
Further research
Material needed: Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Adverse-event collection, exposure, denominators and discontinuation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Adverse-event collection, exposure, denominators and discontinuation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N25 · Are parent values and historical adjustments separated?

Current findings
Preserve parent C50, B/S/R1/I2/EX/B2/CX, four false flags and empty overrides. The historical provisional C54→C50 adjustment is not a new verdict, completed current content review or a generated subclaim score.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks.
Required materials and conditions
Parent/subclaim original values and verdict history
Materials to obtain first
Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks.
Further research
Material needed: Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Parent/subclaim original values and verdict history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Parent/subclaim original values and verdict history with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N26 · Are bilingual wording, dates and corrections distinguished?

Current findings
Preserve original bilingual wording, the fitness/glucose distinction, evidence date 2026-09-07, an empty corrections array and empty deliberation string. The evidence date is not current external-reading/review time; production date 2026-10-06 is also not completed content review.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Additional original versions, actual corrections, complete pre-change history and translation/editorial review records.
Required materials and conditions
Selected/parent bilingual wording, historical date and corrections
Materials to obtain first
Additional original versions, actual corrections, complete pre-change history and translation/editorial review records.
Further research
Material needed: Additional original versions, actual corrections, complete pre-change history and translation/editorial review records. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Selected/parent bilingual wording, historical date and corrections must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Selected/parent bilingual wording, historical date and corrections with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N27 · Which materials and links were actually read?

Current findings
The parent stored summary/bibliography for S01/S02 was read and transferred. Paper URLs are original preserved links; external abstracts, full texts, registration, protocols, SAPs and COI materials are unread, with access not attempted.
Verification status
Partly verified
Materials actually read
Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified
The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information
Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations.
Required materials and conditions
Stored-summary reading, external unread materials and needed evidence
Materials to obtain first
Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations.
Further research
Material needed: Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations. This records needed materials; no new research was executed.
Remaining uncertainty
External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification
Material for Stored-summary reading, external unread materials and needed evidence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed
This condition connects Stored-summary reading, external unread materials and needed evidence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
Application exceptions
Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
Referenced methods
Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02