# Vigorous stair exercise snacks × six-week cardiorespiratory fitness

Verdict 2996 · Evidence Check

Stored-material review date: Not recorded  
Original evidence cut-off: 2026-09-07  
Review-criteria version: 1.0  
Public page/material preparation date: 2026-10-16

Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect.

## Assessment scope

- Population: Direct fitness report S01 concerns 24 inactive young adults, with 12 assigned to stairs and 12 to no training. Completion, endpoint-specific analysis, exact eligibility/baseline values and applicability to everyone are unverified. S02’s 12 lean men and 11 overweight/obese participants are separate acute populations and are not summed.
- Ingredient, formulation and route: S01 records original research conditions of 60-step ascents 3 times daily, separated by 1–4 hours, 3 days weekly for 6 weeks. Actual intensity, supervision and adherence are unlinked. Distinguish S02’s acute 15–30-second, 8-bout, 9-hour exposure; research identification is not turned into exercise instructions.
- Dose: Preserve the original 60 steps, 3 times daily, 3 days weekly and 6 weeks as research conditions only. Actual exposure variation, discontinuation, adherence and concurrent activity are unverified. No new step/frequency/time/exposure totals, calories or personal exercise doses are calculated or prescribed.
- Comparator: S01 used a no-training comparator. Actual control activity, contact and expectancy differences are unverified. S02’s uninterrupted sitting, ordinary walking, continuous stair exercise and generic bodyweight exercise are not treated as identical comparisons.
- Measured outcome: The selected endpoint is 6-week VO2peak. Distinguish between-group P=.003, the approximately 5% improvement description and missing exact effects/95% CIs. Approximately 5% is not an adjusted between-group effect. Units, test procedures, blinding, endpoint hierarchy, models, precision and clinical importance are unverified.
- Duration: The selected question concerns 6-week fitness measurement. S02’s 9-hour acute insulin/glucose AUC and post-training fitness persistence/long-term disease outcomes are separate. Preserve the original long-term outcome gap without extending findings to diabetes or cardiovascular-disease prevention.
- Questions outside this scope: Generating adjusted between-group effects, 95% CIs or clinical importance from approximately 5% wording or P=.003; Transferring S02 acute insulin/glucose findings into 6-week VO2peak effects or improvement in both fitness and glucose; Summing two experiments in S02, 12 lean/11 overweight participants or shared sheets into participant, unique-trial or independent-replication totals; Inheriting parent C50, B/S/R1/I2/EX/B2/CX or historical C54→C50 adjustment as absent subclaim values or a new verdict; Extending a short-term fitness signal in selected young adults to all ages/diseases, long-term disease prevention or safety; Combining ordinary walking, continuous stairs or bodyweight exercise as the same intervention or generating exposure totals, exercise instructions, medication changes or treatment guidance

## Checklist items

### N01 · Which 6-week fitness claim is being checked?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The existing subclaim is improved cardiorespiratory fitness over 6 weeks, originally graded C. Its note records between-group P=.003 for VO2peak together with missing exact effects/CIs. Subclaim score, safety and axes are unrecorded and are not filled from parent C50.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: The original selected-subclaim version and claim-boundary/editorial review records.
- Required materials and conditions: Selected subclaim wording, original grade/note and parent context
- Materials to obtain first: The original selected-subclaim version and claim-boundary/editorial review records.
- Further research: Material needed: The original selected-subclaim version and claim-boundary/editorial review records. This records needed materials; no new research was executed.
- Conditions for verification: Material for Selected subclaim wording, original grade/note and parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Selected subclaim wording, original grade/note and parent context with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N02 · Who was studied and what was the allocation size?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S01 records a 6-week trial in 24 inactive young adults, with 12 stair participants and 12 no-training controls. Completion, endpoint-specific analysis denominators and detailed eligibility are unverified; S02 acute populations are separate.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators.
- Required materials and conditions: Eligibility and group-specific allocation, completion and analysis denominators
- Materials to obtain first: S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators.
- Further research: Material needed: S01 eligibility, baseline-characteristics table, participant flow and group-specific completion/analysis denominators. This records needed materials; no new research was executed.
- Conditions for verification: Material for Eligibility and group-specific allocation, completion and analysis denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Eligibility and group-specific allocation, completion and analysis denominators with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N03 · What was the original 6-week intervention exposure?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Original S01 conditions were 60 steps, 3 times daily, separated by 1–4 hours, 3 days weekly for 6 weeks. These identify the research only; they do not establish actual intensity, supervision or adherence and are not exercise instructions.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 intervention specifications, performance records, appendices and actual intensity/supervision materials.
- Required materials and conditions: Research intervention, planned exposure and actual performance
- Materials to obtain first: S01 intervention specifications, performance records, appendices and actual intensity/supervision materials.
- Further research: Material needed: S01 intervention specifications, performance records, appendices and actual intensity/supervision materials. This records needed materials; no new research was executed.
- Conditions for verification: Material for Research intervention, planned exposure and actual performance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Research intervention, planned exposure and actual performance with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N04 · What does the no-training comparison represent?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S01 used no-training controls. This differs from S02 uninterrupted sitting; ordinary walking, continuous stairs and generic bodyweight exercise are not substituted as identical comparisons. Actual control activity/contact is unverified.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 control-management, activity-measurement, contact and expectancy-difference records.
- Required materials and conditions: Control activity, contact and expectancy differences
- Materials to obtain first: S01 control-management, activity-measurement, contact and expectancy-difference records.
- Further research: Material needed: S01 control-management, activity-measurement, contact and expectancy-difference records. This records needed materials; no new research was executed.
- Conditions for verification: Material for Control activity, contact and expectancy differences must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Control activity, contact and expectancy differences with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N05 · Is the randomization process verified?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S01 is labeled a randomized no-training controlled trial. This transfers the preserved design label; it does not establish that original sequence generation, concealment or recruitment order were verified.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 original methods, allocation procedures, recruitment order and research plans.
- Required materials and conditions: Allocation generation, concealment and recruitment order
- Materials to obtain first: S01 original methods, allocation procedures, recruitment order and research plans.
- Further research: Material needed: S01 original methods, allocation procedures, recruitment order and research plans. This records needed materials; no new research was executed.
- Conditions for verification: Material for Allocation generation, concealment and recruitment order must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Allocation generation, concealment and recruitment order with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N06 · Does an objective fitness endpoint establish blinding?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account records objective fitness testing as a strength. Objective-endpoint wording alone does not verify assessor or analyst blinding.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 assessor/analyst blinding records and test procedures.
- Required materials and conditions: Assessor/analyst blinding and test conditions
- Materials to obtain first: S01 assessor/analyst blinding records and test procedures.
- Further research: Material needed: S01 assessor/analyst blinding records and test procedures. This records needed materials; no new research was executed.
- Conditions for verification: Material for Assessor/analyst blinding and test conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Assessor/analyst blinding and test conditions with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N07 · What defines VO2peak, its units and test method?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original S01 endpoint is 6-week VO2peak, also recorded in the parent classification. Exact units, procedures and equipment are unverified; glucose AUC or insulin AUC is not transferred into this endpoint.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables.
- Required materials and conditions: Endpoint definition, equipment, units and measurement timing
- Materials to obtain first: S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables.
- Further research: Material needed: S01 endpoint definition, test procedures, equipment, units, measurement timing and result tables. This records needed materials; no new research was executed.
- Conditions for verification: Material for Endpoint definition, equipment, units and measurement timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Endpoint definition, equipment, units and measurement timing with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N08 · Are between-group P and approximately 5% wording the same effect?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account preserves between-group P=.003 for VO2peak alongside approximately 5% improvement. Approximately 5% is not presented as an exact adjusted between-group effect and is not used to fill that missing estimate.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 group-specific original values, changes, between-group analysis tables and attribution of each described value.
- Required materials and conditions: Test target and attribution of described change
- Materials to obtain first: S01 group-specific original values, changes, between-group analysis tables and attribution of each described value.
- Further research: Material needed: S01 group-specific original values, changes, between-group analysis tables and attribution of each described value. This records needed materials; no new research was executed.
- Conditions for verification: Material for Test target and attribution of described change must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Test target and attribution of described change with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N09 · Are the exact comparative effect and 95% CI available?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S01 results and the subclaim note both record missing exact effects/95% CIs. P=.003 alone is not used to create effect size, precision or CIs.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 between-group analysis tables, estimation models, exact effects and direct CIs.
- Required materials and conditions: Comparative estimator, effect and uncertainty
- Materials to obtain first: S01 between-group analysis tables, estimation models, exact effects and direct CIs.
- Further research: Material needed: S01 between-group analysis tables, estimation models, exact effects and direct CIs. This records needed materials; no new research was executed.
- Conditions for verification: Material for Comparative estimator, effect and uncertainty must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Comparative estimator, effect and uncertainty with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N10 · Is the practical size of the fitness signal known?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account records an objective fitness signal in a small sample. Statistical significance alone does not establish personally perceived benefit, disease prevention or clinical importance.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 effect distributions, measurement error and practical/clinical relevance criteria.
- Required materials and conditions: Effect magnitude, measurement error and relevance criteria
- Materials to obtain first: S01 effect distributions, measurement error and practical/clinical relevance criteria.
- Further research: Material needed: S01 effect distributions, measurement error and practical/clinical relevance criteria. This records needed materials; no new research was executed.
- Conditions for verification: Material for Effect magnitude, measurement error and relevance criteria must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Effect magnitude, measurement error and relevance criteria with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N11 · Are 24 participants the completion/analysis denominator?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original sample size is 24 (12/12). It is not automatically treated as complete 6-week testing for everyone or the ITT analysis denominator.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators.
- Required materials and conditions: Allocation, completion, endpoint-specific analysis and missing data
- Materials to obtain first: S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators.
- Further research: Material needed: S01 participant flow, group-specific missing-data reasons, analysis-population definitions and endpoint denominators. This records needed materials; no new research was executed.
- Conditions for verification: Material for Allocation, completion, endpoint-specific analysis and missing data must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Allocation, completion, endpoint-specific analysis and missing data with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N12 · Does planned exposure equal actual adherence?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account contains planned stair exposure and the 6-week duration, but actual adherence information is unlinked. Planned exposure is not converted into actual performance by everyone.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 adherence, discontinuation, exposure-variation and activity-monitoring records.
- Required materials and conditions: Actual performance, discontinuation and exposure variation
- Materials to obtain first: S01 adherence, discontinuation, exposure-variation and activity-monitoring records.
- Further research: Material needed: S01 adherence, discontinuation, exposure-variation and activity-monitoring records. This records needed materials; no new research was executed.
- Conditions for verification: Material for Actual performance, discontinuation and exposure variation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Actual performance, discontinuation and exposure variation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N13 · Are concurrent activity and lifestyle changes separated?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The selected question is limited to the original distributed stair program. Ordinary walking, continuous stairs and bodyweight exercise snacks are not combined as the same intervention; concurrent activity and lifestyle changes are unverified.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans.
- Required materials and conditions: Other exercise, daily activity and group-specific lifestyle changes
- Materials to obtain first: S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans.
- Further research: Material needed: S01 concurrent activity, lifestyle changes, baseline covariates and adjustment plans. This records needed materials; no new research was executed.
- Conditions for verification: Material for Other exercise, daily activity and group-specific lifestyle changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Other exercise, daily activity and group-specific lifestyle changes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N14 · Are prespecified endpoints, registration and plans verified?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original S01 evidence row has no nct key and its citation has no registration identifier. Parent primary-endpoint classification is preserved classification, not proof of a prespecified primary endpoint or absence of registration.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy.
- Required materials and conditions: Registration, protocols, SAPs and endpoint hierarchy
- Materials to obtain first: S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy.
- Further research: Material needed: S01 original registration, protocols, SAPs, change history and actual endpoint hierarchy. This records needed materials; no new research was executed.
- Conditions for verification: Material for Registration, protocols, SAPs and endpoint hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Registration, protocols, SAPs and endpoint hierarchy with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N15 · Are analysis models and multiplicity plans available?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserved results record between-group P=.003, but test models, adjustment variables and multiplicity plans are unlinked.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans.
- Required materials and conditions: Between-group tests, adjustment variables and multiple comparisons
- Materials to obtain first: S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans.
- Further research: Material needed: S01 SAP, complete endpoint-analysis tables, between-group models and prespecified multiplicity plans. This records needed materials; no new research was executed.
- Conditions for verification: Material for Between-group tests, adjustment variables and multiple comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Between-group tests, adjustment variables and multiple comparisons with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N16 · Is the acute metabolic protocol the same?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S02 was an acute crossover comparison of 8 hourly stair bouts lasting 15–30 seconds over 9 hours versus uninterrupted sitting. This differs from S01’s 60 steps, 3 times daily for 6 weeks and is not used as replication of 6-week fitness.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S02 complete intervention, comparator, duration, actual-exposure and endpoint tables.
- Required materials and conditions: Separating 6-week training from acute exposure, comparator and duration
- Materials to obtain first: S02 complete intervention, comparator, duration, actual-exposure and endpoint tables.
- Further research: Material needed: S02 complete intervention, comparator, duration, actual-exposure and endpoint tables. This records needed materials; no new research was executed.
- Conditions for verification: Material for Separating 6-week training from acute exposure, comparator and duration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Separating 6-week training from acute exposure, comparator and duration with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N17 · How do the two experiments in S02 relate?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: One S02 report contains two acute crossover experiments, with 12 lean men and 11 overweight/obese participants in separate populations. They are not summed into one participant denominator or a new unique-trial total.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships.
- Required materials and conditions: Report, experiments and population-specific correspondence
- Materials to obtain first: S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships.
- Further research: Material needed: S02 experiment-specific flow, methods, eligibility, analysis denominators and population relationships. This records needed materials; no new research was executed.
- Conditions for verification: Material for Report, experiments and population-specific correspondence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Report, experiments and population-specific correspondence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S02

### N18 · Are acute insulin/glucose findings fitness effects?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S02 overweight-group insulin AUC −16.5%, P=.036, d=.94 and null glucose/triglycerides at P>.31 are acute metabolic findings. They are not converted into 6-week VO2peak effects or improvement in both fitness and glucose.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans.
- Required materials and conditions: Separate VO2peak and insulin/glucose AUC outcomes
- Materials to obtain first: Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans.
- Further research: Material needed: Original report/population/endpoint results, units, denominators, direct effects/CIs and prespecified analysis plans. This records needed materials; no new research was executed.
- Conditions for verification: Material for Separate VO2peak and insulin/glucose AUC outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Separate VO2peak and insulin/glucose AUC outcomes with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N19 · Is independent replication of the same protocol verified?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account records a gap in independent same-protocol replication. S02’s different acute protocol/two experiments and shared reports across both sheets are not counted as independent replication of S01; no new certification of absence across all literature is made here.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Separate same-protocol trials, researchers, cohorts and study-family relationships.
- Required materials and conditions: Study families, the same protocol and outcome relationships
- Materials to obtain first: Separate same-protocol trials, researchers, cohorts and study-family relationships.
- Further research: Material needed: Separate same-protocol trials, researchers, cohorts and study-family relationships. This records needed materials; no new research was executed.
- Conditions for verification: Material for Study families, the same protocol and outcome relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Study families, the same protocol and outcome relationships with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N20 · Do 6-week findings establish persistence or disease prevention?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The selected question concerns 6-week fitness. Preserve the original long-term disease-outcome gap without extending findings into diabetes/cardiovascular-disease prevention or persistent long-term fitness.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes.
- Required materials and conditions: Post-training fitness persistence and clinical endpoints
- Materials to obtain first: Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes.
- Further research: Material needed: Post-training fitness measurements, sufficient follow-up and direct long-term clinical outcomes. This records needed materials; no new research was executed.
- Conditions for verification: Material for Post-training fitness persistence and clinical endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Post-training fitness persistence and clinical endpoints with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N21 · Does this apply across ages and diseases?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The original account records selection of inactive adults able to perform vigorous stair movements. Findings are not generalized into fitness effects or safety across all ages/diseases.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials.
- Required materials and conditions: Population-specific direct materials and selection boundaries
- Materials to obtain first: Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials.
- Further research: Material needed: Population-specific eligibility, baseline status, subgroup plans and direct endpoint materials. This records needed materials; no new research was executed.
- Conditions for verification: Material for Population-specific direct materials and selection boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Population-specific direct materials and selection boundaries with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N22 · What are S01 funding, support and interests?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S01 records McMaster internal, CIHR and scholarship support. Public-funding wording does not establish that all product support, author interests or analysis/reporting roles are verified.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
- Required materials and conditions: Funding, product support, employee authors and COI
- Materials to obtain first: S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
- Further research: Material needed: S01 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
- Conditions for verification: Material for Funding, product support, employee authors and COI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Funding, product support, employee authors and COI with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01

### N23 · Is the S02 support gap separate?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: S02 support details are unverified. S01 information is not used to fill S02 funding, product support, employee-author or COI details.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
- Required materials and conditions: Report-specific funding, support and interests
- Materials to obtain first: S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles.
- Further research: Material needed: S02 original funding, product/equipment support, affiliations, COI and analysis/publication roles. This records needed materials; no new research was executed.
- Conditions for verification: Material for Report-specific funding, support and interests must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Report-specific funding, support and interests with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S02

### N24 · Are systematic safety materials available?

Verification status: Unverified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Parent safety status is Caution and the original account records unavailable systematic adverse-event rates. Mentioned stair-fall/high-intensity-exercise risks are not actual incidence rates or safety verdicts for everyone.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials.
- Required materials and conditions: Adverse-event collection, exposure, denominators and discontinuation
- Materials to obtain first: Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials.
- Further research: Material needed: Report-specific adverse-event definitions, collection, exposure, denominators, discontinuation, severity and follow-up materials. This records needed materials; no new research was executed.
- Conditions for verification: Material for Adverse-event collection, exposure, denominators and discontinuation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Adverse-event collection, exposure, denominators and discontinuation with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N25 · Are parent values and historical adjustments separated?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve parent C50, B/S/R1/I2/EX/B2/CX, four false flags and empty overrides. The historical provisional C54→C50 adjustment is not a new verdict, completed current content review or a generated subclaim score.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks.
- Required materials and conditions: Parent/subclaim original values and verdict history
- Materials to obtain first: Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks.
- Further research: Material needed: Complete preserved originals, historical verdict materials and selected-subclaim/parent boundary checks. This records needed materials; no new research was executed.
- Conditions for verification: Material for Parent/subclaim original values and verdict history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Parent/subclaim original values and verdict history with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N26 · Are bilingual wording, dates and corrections distinguished?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: Preserve original bilingual wording, the fitness/glucose distinction, evidence date 2026-09-07, an empty corrections array and empty deliberation string. The evidence date is not current external-reading/review time; production date 2026-10-06 is also not completed content review.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Additional original versions, actual corrections, complete pre-change history and translation/editorial review records.
- Required materials and conditions: Selected/parent bilingual wording, historical date and corrections
- Materials to obtain first: Additional original versions, actual corrections, complete pre-change history and translation/editorial review records.
- Further research: Material needed: Additional original versions, actual corrections, complete pre-change history and translation/editorial review records. This records needed materials; no new research was executed.
- Conditions for verification: Material for Selected/parent bilingual wording, historical date and corrections must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Selected/parent bilingual wording, historical date and corrections with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

### N27 · Which materials and links were actually read?

Verification status: Partly verified  
Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread

- Current findings: The parent stored summary/bibliography for S01/S02 was read and transferred. Paper URLs are original preserved links; external abstracts, full texts, registration, protocols, SAPs and COI materials are unread, with access not attempted.
- Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
- Reason for missing information: Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations.
- Required materials and conditions: Stored-summary reading, external unread materials and needed evidence
- Materials to obtain first: Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations.
- Further research: Material needed: Report-specific originals, registration, plans, support materials and actual acquisition/reading records. Preserve originals and versions before updating observations. This records needed materials; no new research was executed.
- Conditions for verification: Material for Stored-summary reading, external unread materials and needed evidence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
- Why this condition is needed: This condition connects Stored-summary reading, external unread materials and needed evidence with the 6-week fitness question, inactive young adults, stair training versus no training, VO2peak, missing between-group effects/CIs, acute metabolic background, report-specific support and harms.
- Application exceptions: Preserve original exposure/numbers, selected grade C and absent subclaim score, safety and axes. Distinguish P=.003, the approximately 5% description and missing exact between-group effects/CIs. S01 6-week fitness and S02 9-hour acute metabolism use different protocols, populations, comparators and endpoints. No new effects, CIs, exposure/participant/trial totals, independence certification, grades, exercise instructions, medication changes or treatment guidance are created.
- Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
- Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.
- Related sources: S01, S02

## Evidence and sources

### S01

Jenkins EM, Nairn LN, Skelly LE, Little JP, Gibala MJ. Do stair climbing exercise 'snacks' improve cardiorespiratory fitness? Appl Physiol Nutr Metab. 2019;44(6):681-684. PMID: 30649897. DOI: 10.1139/apnm-2018-0675.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/30649897/)

Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread  
Findings recorded in the summary: Between-group P=.003; exact effect and 95% CI unverified  
Record level: Direct small trial for selected 6-week fitness. Preserve the original 24 participants (12/12) and P=.003. Approximately 5% wording is not an exact adjusted between-group effect; CIs, units, test methods, completion/analysis denominators and prespecified endpoints are unverified. It is not a direct report of reduced glucose or disease prevention.  
Independent replication: Parent 2996 and the fitness/glucose sheets share the same two reports. S01 concerns 6-week fitness training; S02 contains two acute crossover experiments under a different 9-hour protocol, with 12 lean and 11 overweight/obese participants in separate populations. Reports, sheets, experiments and populations are not summed into new unique-trial, participant or independent-replication totals; confirmed totals, cohort relationships and independence are unverified.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |
| External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |
| Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |
| Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |
| Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |
| Funding, product-support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 30649897 and DOI 10.1139/apnm-2018-0675. PMCID/registration identifiers are unrecorded and the evidence object has no nct key. Missing identifiers do not certify absence of registration; registration, protocol, SAP and endpoint prospective status are unverified. |

### S02

Rafiei H, Omidian K, Myette-Côté É, Little JP. Metabolic Effect of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks. Med Sci Sports Exerc. 2021;53(1):150-158. PMID: 32555024. DOI: 10.1249/MSS.0000000000002431.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/32555024/)

Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread  
Findings recorded in the summary: Overweight-group insulin −16.5%, P=.036; glucose null  
Record level: Background from a different acute protocol for the selected fitness question. Distinguish 12 lean men from 11 overweight/obese participants; preserve the original 9 hours, 8 bouts of 15–30 seconds and uninterrupted-sitting comparison. Overweight-group insulin AUC −16.5%/P=.036/d=.94 and null glucose/triglycerides at P>.31 are not 6-week fitness effects.  
Independent replication: Parent 2996 and the fitness/glucose sheets share the same two reports. S01 concerns 6-week fitness training; S02 contains two acute crossover experiments under a different 9-hour protocol, with 12 lean and 11 overweight/obese participants in separate populations. Reports, sheets, experiments and populations are not summed into new unique-trial, participant or independent-replication totals; confirmed totals, cohort relationships and independence are unverified.

| Material | Public availability | Access status | Actually read | Notes |
|---|---|---|---|---|
| Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |
| External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |
| Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |
| Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |
| Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |
| Funding, product-support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the original PubMed URL, PMID 32555024 and DOI 10.1249/MSS.0000000000002431. PMCID/registration identifiers are unrecorded. No new registry/full-text URLs are inferred; original primary-insulin wording is distinguished from actual registration/analysis prospective status. |

## Review criteria and methods

These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score.

- M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.
- M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

## What the statuses mean

- Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete.
- Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
- Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
- Review incomplete: User review pending.
- Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
- Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
- Not applicable: Not used as a substitute for an evidence gap.
- Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
- Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

## Change history

2026-10-16 · Public page/materials 1.0. Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.