WW 52 versus 12 weeks · Weight loss at 12 months — Evidence Check

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Efficacy comparison · Preserved-material preparationWhat are the original selected question and subclaim verdict?Required	The original subclaim concerns weight loss at 12 months, grade C, with the note that 52 weeks produced 2.14 kg more loss than 12 weeks. The parent has C with 50 points and separate axes. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Original wording, subclaim grade/note and parent context for weight loss at 12 months	Record the original verdict, this preparation and existing-content review as separate events.
2	Partly verified	Full text not readStored summary read	N02 · Efficacy comparison · Preserved-material preparationDoes the selected comparison concern durations of the same WW program?Required	The parent outcome is greater weight loss at 12 months than the 12-week program. The comparator also received a 12-week referral to the same WW program and was an active control. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Actual interventions and comparison questions for 52 weeks, 12 weeks and brief intervention	Present duration comparison and comparisons with other controls as separate questions.
3	Partly verified	Full text not readStored summary read	N03 · Efficacy comparison · Preserved-material preparationWho was recruited, and what is the applicability?Required	The trial randomized 1,267 adults with BMI at least 28 in UK primary care. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Primary-care population eligibility, exclusions and baseline characteristics	Present the recruited population and applicable question scope.
4	Partly verified	Full text not readStored summary read	N04 · Efficacy comparison · Preserved-material preparationWhat was the research identity of the 52-week intervention?Required	The original intervention is the commercial WW weight-management program with one group meeting per week for 52 weeks. Its identity as provision of program access is retained. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Program, meetings, referral and actual participation/exposure specifications	Distinguish the intervention’s research identity from actual participation and exposure.
5	Partly verified	Full text not readStored summary read	N05 · Efficacy comparison · Preserved-material preparationAre the 12-week active control and brief-intervention group kept separate?Required	Participants were allocated to brief intervention, 211, WW for 12 weeks, 528, or 52 weeks, 528. The 52- versus 12-week comparison concerns durations of the same program. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Contents, denominators and effect of interest for each comparison group	Retain all three groups while displaying the selected two-group effect separately.
6	Partly verified	Full text not readStored summary read	N06 · Efficacy comparison · Preserved-material preparationHave allocation, concealment and masking details been read?Required	The original evidence describes a three-arm randomized controlled trial. Parent bias B2 is historical verdict information. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Randomization sequence, concealment and outcome-assessor masking materials	Distinguish the design label from actual implementation details.
7	Partly verified	Full text not readStored summary read	N07 · Efficacy comparison · Preserved-material preparationAre randomized and measured 12-month denominators distinguished?Required	The preserved summary records 1,267 allocated (211/528/528), with measured 12-month weight for 823/1,267 (65%). R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Group-specific flow through allocation, follow-up, measurement and analysis	Present allocation, measurement and analysis denominators separately.
8	Partly verified	Full text not readStored summary read	N08 · Efficacy comparison · Preserved-material preparationAre missing measurements and multiple imputation retained in interpretation?Required	The original account of 35% missing measured 12-month weight and use of multiple imputation is retained. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Group-specific missingness reasons, imputation models/assumptions and sensitivity analysis	Present measured information separately from assumption-based analyses.
9	Unverified	Full text not readStored summary read	N09 · Efficacy comparison · Preserved-material preparationAre actual attendance, co-exposure and between-group changes verified?Required	The original materials describe referral allocation and the research identity of one group meeting per week. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Attendance, program use, accompanying management and group-change materials	Distinguish allocation effects from actual participation and accompanying exposure.
10	Partly verified	Full text not readStored summary read	N10 · Efficacy comparison · Preserved-material preparationAre weight measurement and timing specified?Required	The primary endpoint was weight at one year; the evidence records weight at 12 months. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	One-year weight measurement procedure, equipment, units and timing	Present weight, measurement timing and units together.
11	Partly verified	Full text not readStored summary read	N11 · Efficacy comparison · Preserved-material preparationAre within-group changes and adjusted between-group differences separate values?Required	At 12 months, weight change was -4.75 kg with 12 weeks and -6.76 kg with 52 weeks; the adjusted between-group difference was -2.14 kg. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Original within-group changes and adjusted between-group estimate	Display within-group changes separately alongside the adjusted between-group effect.
12	Partly verified	Full text not readStored summary read	N12 · Efficacy comparison · Preserved-material preparationWhat are the 12-month between-group effect, interval and test?Required	The recorded adjusted between-group difference is -2.14 kg, 95% CI -3.05 to -1.22, P<.0001. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Directly reported difference, CI and P value for selected 52 versus 12 weeks	Present directly reported values with precision and applicability limits.
13	Partly verified	Full text not readStored summary read	N13 · Efficacy comparison · Preserved-material preparationAre the adjustment model and effect of interest known?Required	The original account explicitly identifies an adjusted difference and multiple imputation for 35% missingness. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Covariates, analysis population, imputation and model specifications	Distinguish allocation, participation and completer effects from imputed estimates.
14	Partly verified	Full text not readStored summary read	N14 · Efficacy comparison · Preserved-material preparationAre the preceding and selected hierarchical comparisons distinguished?Required	The summary reports that both program groups combined were first compared with brief intervention, passing with -2.71 kg, 95% CI -3.86 to -1.55, P<.0001, before comparing 52 with 12 weeks. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Original testing order, plans and results for preceding and subsequent comparisons	Link the preceding gatekeeping comparison separately from the selected effect.
15	Partly verified	Full text not readStored summary read	N15 · Efficacy comparison · Preserved-material preparationWhat is the reading scope for registration and plans?Required	The account states registration preceded recruitment; the evidence identifier is ISRCTN82857232. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Registration identifier/timing, protocol, SAP and change history	Distinguish the original identifier from actual material reading and prespecification.
16	Partly verified	Full text not readStored summary read	N16 · Efficacy comparison · Preserved-material preparationAre sample-size assumptions distinguished from minimum clinical importance?Required	The summary states that a sample of 1,200 assumed detection of a 1.3 kg difference, which was not a declared minimum clinically important difference. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Sample-size assumptions and declared importance criterion	Present detection assumptions separately from clinical importance.
17	Partly verified	Full text not readStored summary read	N17 · Efficacy comparison · Preserved-material preparationAre 12-month and 24-month effects distinguished?Required	The recorded 24-month difference is -1.32 kg, 95% CI -2.46 to -0.18, P=.0231. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Actual comparison, effect, denominator and subsequent exposure by time point	Display one-year and 24-month estimates separately.
18	Partly verified	Full text not readStored summary read	N18 · Efficacy comparison · Preserved-material preparationDoes 12-month superiority establish five-year maintenance?Required	The original account records a null 52- versus 12-week result at five years: -0.80 kg, 95% CI -2.13 to 0.54. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Direct five-year comparison and uncertainty in the same trial	Distinguish short-term superiority from the long-term null result.
19	Partly verified	Full text not readStored summary read	N19 · Efficacy comparison · Preserved-material preparationAre five-year measurements and follow-up denominators separate from 12 months?Required	The long-term citation is the WRAP five-year follow-up. Measured 12-month weight in 823 and 35% missingness concern one year. R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Five-year follow-up, measurements, group denominators, missingness and analysis assumptions	Separate actual observed and analysis denominators by time point.
20	Partly verified	Full text not readStored summary read	N20 · Efficacy comparison · Preserved-material preparationIs weight loss being extended to other clinical outcomes?Required	The currently preserved evidence has weight at 12 months as its primary endpoint. The long-term citation title mentions effectiveness and cost-effectiveness. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Direct outcomes for weight versus clinical events, function and quality of life	Distinguish weight change from direct evidence for other outcomes.
21	Partly verified	Full text not readStored summary read	N21 · Efficacy comparison · Preserved-material preparationAre the main report, five-year follow-up and sibling sheets kept within the same trial?Required	The 2017 WRAP main report and 2022 five-year follow-up are identified as reports of the same trial. The two sheets share parent summary 2964 and two subclaim records. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	WRAP bibliography, registration, participants and follow-up relationships	Distinguish report slots from trial and participant units.
22	Partly verified	Full text not readStored summary read	N22 · Efficacy comparison · Preserved-material preparationAre other independent replications and generalization materials available?Required	The preserved summary identifies only the WRAP main report and same-trial long-term follow-up. Parent replication R1 is a historical label. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Actual independent reports for the same comparison, population and duration	Distinguish follow-up in the same cohort from other independent replication.
23	Partly verified	Full text not readStored summary read	N23 · Efficacy comparison · Preserved-material preparationAre consortium funding, industry funding and program access distinguished?Required	Public/nonprofit consortium funding accompanied WW International industry-partner funding and program access. The UK MRC Industrial Collaboration Award relationship is retained. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Research funding, program support, contracts and sponsor-role disclosures	Display public, nonprofit and industry funding separately from program support.
24	Partly verified	Full text not readStored summary read	N24 · Efficacy comparison · Preserved-material preparationAre WW funding to authors’ institutions and employee authors distinguished?Required	The account states that five authors disclosed WW research funding received by their institutions. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Author-specific affiliations, contributions, institutional support and COI disclosures	Distinguish institutional support from employment, analysis and publication roles.
25	Unverified	Full text not readStored summary read	N25 · Efficacy comparison · Preserved-material preparationAre contracted analysis, medical writing, publication fees and program control known?Required	The summary describes industry funding, program access and funding relationships involving authors’ institutions. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Industry-partner/researcher, analysis, writing and publication role disclosures	Present reported support separately from unverified roles.
26	Partly verified	Full text not readStored summary read	N26 · Supplementary harm evidenceWhat is the scope of the intervention-related adverse-event account?Supplementary	The summary states that the paper reported no intervention-related adverse events but did not provide a group-specific table of all adverse events. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Event definitions, causal classification, collection and group-specific exposure denominators	Distinguish all events from intervention-related events.
27	Partly verified	Full text not readStored summary read	N27 · Supplementary harm evidenceIs equal safety between the two referral durations established?Supplementary	The preserved safety account states that without an all-event table by group, equal safety between the durations cannot be concluded. R01	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Duration-specific harms comparisons, estimates, intervals and denominators	Distinguish efficacy superiority from harms comparisons and equivalence.
28	Unverified	Full text not readStored summary read	N28 · Supplementary harm evidenceAre separate long-term and rare-harm materials required?Supplementary	The main-report account describes no intervention-related adverse events and absence of an all-event table; the subsequent bibliography concerns five-year follow-up. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Actual long-term follow-up, discontinuation, exposure and rare-event materials	Present long-term weight effects separately from long-term safety information.
29	Partly verified	Full text not readStored summary read	N29 · Efficacy comparison · Preserved-material preparationAre the read summary and unread external materials distinguished?Required	What was actually read was the complete preserved parent JSON summary. The main-report PubMed and five-year repository URLs are linked as in the originals. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Preserved JSON, bibliography links, abstract, full-text, registration and planning status	Show summary reading separately from material-specific external nonreading
30	Partly verified	Full text not readStored summary read	N30 · Efficacy comparison · Preserved-material preparationAre original verdict/history and candidate states separate from preparation?Required	Korean/English, original axes, 2026-08-26 reference date, empty corrections/deliberation and subclaims are retained in the complete summary. Original candidate pending/eligible states are preserved history. R01 R02	Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.	Korean/English, axes, dates, corrections, selected record link and preparation events	Record original history, preparation and existing-content review as separate events.

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30 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-08-26
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: 1,267 adults with BMI at least 28 originally allocated in UK primary care; five-year measured/analysis denominators are unverified
Ingredient, formulation and route: Allocation to WW program access for 52 weeks; the intervention’s research identity is weekly group meetings
Dose: Research program duration of 52 weeks; actual attendance and post-program exposure details are unread; this is not implementation guidance
Comparator: Active control with access to the same WW program for 12 weeks; brief intervention is a separate third group
Measured outcome: Weight at 12 months and adjusted between-group difference, distinguished from within-group changes and the preceding hierarchical comparison
Duration: 12 months, 24 months and five years are distinguished; program-access duration differs from assessment timing
Questions outside this scope: No new effects, CIs, calculations, verdicts, independence certification, participant totals, product recommendations or diet/exercise/weight-loss/treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Ahern AL, et al. Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial. Lancet. 2017;389:2214-2225. PMID: 28478041.

PubMed

Material type: Preserved summary of the original trial-paper bibliography
Materials actually read: Preserved JSON summary read; external reports, registration and plans unread
Findings recorded in the stored summary: 52 versus 12 weeks adjusted difference -2.14 kg (95% CI -3.05 to -1.22), P<.0001
Record level: Adjusted 12-month 52- versus 12-week difference, separated from the preceding comparison, within-group changes and long-term results
Study overlap and independent replication: The preserved summary links the WRAP main report and five-year follow-up of the same trial; two papers, three groups, time points, sibling sheets and registration do not certify independent replications or participant totals

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored summary	Summary read	Stored summary read	Summary read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
External abstract	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
External full text	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
Original registration	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
Protocol/SAP	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained

R02 · Ahern AL, et al. Effectiveness and cost-effectiveness of referral to a commercial open group behavioural weight management programme in adults with overweight and obesity: 5-year follow-up of WRAP. Lancet Public Health. 2022.

Official source

Material type: Bibliography of the same trial’s long-term follow-up report
Materials actually read: Preserved JSON summary read; external reports, registration and plans unread
Findings recorded in the stored summary: The 24-month difference was -1.32 kg (95% CI -2.46 to -0.18), P=.0231; at five years the difference was null, -0.80 kg (-2.13 to 0.54). Durable superiority was not established.
Record level: Original 24-month and five-year accounts distinguished by time point; the five-year result is preserved in its existing subclaim note
Study overlap and independent replication: The preserved summary links the WRAP main report and five-year follow-up of the same trial; two papers, three groups, time points, sibling sheets and registration do not certify independent replications or participant totals

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored summary	Summary read	Stored summary read	Summary read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
External abstract	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
External full text	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
Original registration	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained
Protocol/SAP	Not read	External material unread	Not read	Material slots do not certify external acquisition, actual reading, link checking or numbers of independent trials; a repository URL also does not mean an external document was obtained

Report counts versus independent study counts

The preserved summary links the WRAP main report and five-year follow-up of the same trial; two papers, three groups, time points, sibling sheets and registration do not certify independent replications or participant totals

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · What are the original selected question and subclaim verdict?

Required materials and conditions: Original wording, subclaim grade/note and parent context for weight loss at 12 months
Conditions for verification: Original wording, subclaim grade/note and parent context for weight loss at 12 months; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N02 · Does the selected comparison concern durations of the same WW program?

Required materials and conditions: Actual interventions and comparison questions for 52 weeks, 12 weeks and brief intervention
Conditions for verification: Actual interventions and comparison questions for 52 weeks, 12 weeks and brief intervention; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N03 · Who was recruited, and what is the applicability?

Required materials and conditions: Primary-care population eligibility, exclusions and baseline characteristics
Conditions for verification: Primary-care population eligibility, exclusions and baseline characteristics; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N04 · What was the research identity of the 52-week intervention?

Required materials and conditions: Program, meetings, referral and actual participation/exposure specifications
Conditions for verification: Program, meetings, referral and actual participation/exposure specifications; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N05 · Are the 12-week active control and brief-intervention group kept separate?

Required materials and conditions: Contents, denominators and effect of interest for each comparison group
Conditions for verification: Contents, denominators and effect of interest for each comparison group; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N06 · Have allocation, concealment and masking details been read?

Required materials and conditions: Randomization sequence, concealment and outcome-assessor masking materials
Conditions for verification: Randomization sequence, concealment and outcome-assessor masking materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N07 · Are randomized and measured 12-month denominators distinguished?

Required materials and conditions: Group-specific flow through allocation, follow-up, measurement and analysis
Conditions for verification: Group-specific flow through allocation, follow-up, measurement and analysis; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N08 · Are missing measurements and multiple imputation retained in interpretation?

Required materials and conditions: Group-specific missingness reasons, imputation models/assumptions and sensitivity analysis
Conditions for verification: Group-specific missingness reasons, imputation models/assumptions and sensitivity analysis; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N09 · Are actual attendance, co-exposure and between-group changes verified?

Required materials and conditions: Attendance, program use, accompanying management and group-change materials
Conditions for verification: Attendance, program use, accompanying management and group-change materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N10 · Are weight measurement and timing specified?

Required materials and conditions: One-year weight measurement procedure, equipment, units and timing
Conditions for verification: One-year weight measurement procedure, equipment, units and timing; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N11 · Are within-group changes and adjusted between-group differences separate values?

Required materials and conditions: Original within-group changes and adjusted between-group estimate
Conditions for verification: Original within-group changes and adjusted between-group estimate; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N12 · What are the 12-month between-group effect, interval and test?

Required materials and conditions: Directly reported difference, CI and P value for selected 52 versus 12 weeks
Conditions for verification: Directly reported difference, CI and P value for selected 52 versus 12 weeks; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N13 · Are the adjustment model and effect of interest known?

Required materials and conditions: Covariates, analysis population, imputation and model specifications
Conditions for verification: Covariates, analysis population, imputation and model specifications; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N14 · Are the preceding and selected hierarchical comparisons distinguished?

Required materials and conditions: Original testing order, plans and results for preceding and subsequent comparisons
Conditions for verification: Original testing order, plans and results for preceding and subsequent comparisons; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N15 · What is the reading scope for registration and plans?

Required materials and conditions: Registration identifier/timing, protocol, SAP and change history
Conditions for verification: Registration identifier/timing, protocol, SAP and change history; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N16 · Are sample-size assumptions distinguished from minimum clinical importance?

Required materials and conditions: Sample-size assumptions and declared importance criterion
Conditions for verification: Sample-size assumptions and declared importance criterion; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N17 · Are 12-month and 24-month effects distinguished?

Required materials and conditions: Actual comparison, effect, denominator and subsequent exposure by time point
Conditions for verification: Actual comparison, effect, denominator and subsequent exposure by time point; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N18 · Does 12-month superiority establish five-year maintenance?

Required materials and conditions: Direct five-year comparison and uncertainty in the same trial
Conditions for verification: Direct five-year comparison and uncertainty in the same trial; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N19 · Are five-year measurements and follow-up denominators separate from 12 months?

Required materials and conditions: Five-year follow-up, measurements, group denominators, missingness and analysis assumptions
Conditions for verification: Five-year follow-up, measurements, group denominators, missingness and analysis assumptions; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N20 · Is weight loss being extended to other clinical outcomes?

Required materials and conditions: Direct outcomes for weight versus clinical events, function and quality of life
Conditions for verification: Direct outcomes for weight versus clinical events, function and quality of life; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N21 · Are the main report, five-year follow-up and sibling sheets kept within the same trial?

Required materials and conditions: WRAP bibliography, registration, participants and follow-up relationships
Conditions for verification: WRAP bibliography, registration, participants and follow-up relationships; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N22 · Are other independent replications and generalization materials available?

Required materials and conditions: Actual independent reports for the same comparison, population and duration
Conditions for verification: Actual independent reports for the same comparison, population and duration; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N23 · Are consortium funding, industry funding and program access distinguished?

Required materials and conditions: Research funding, program support, contracts and sponsor-role disclosures
Conditions for verification: Research funding, program support, contracts and sponsor-role disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N24 · Are WW funding to authors’ institutions and employee authors distinguished?

Required materials and conditions: Author-specific affiliations, contributions, institutional support and COI disclosures
Conditions for verification: Author-specific affiliations, contributions, institutional support and COI disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N25 · Are contracted analysis, medical writing, publication fees and program control known?

Required materials and conditions: Industry-partner/researcher, analysis, writing and publication role disclosures
Conditions for verification: Industry-partner/researcher, analysis, writing and publication role disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N26 · What is the scope of the intervention-related adverse-event account?

Required materials and conditions: Event definitions, causal classification, collection and group-specific exposure denominators
Conditions for verification: Event definitions, causal classification, collection and group-specific exposure denominators; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Supplementary
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N27 · Is equal safety between the two referral durations established?

Required materials and conditions: Duration-specific harms comparisons, estimates, intervals and denominators
Conditions for verification: Duration-specific harms comparisons, estimates, intervals and denominators; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Supplementary
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N28 · Are separate long-term and rare-harm materials required?

Required materials and conditions: Actual long-term follow-up, discontinuation, exposure and rare-event materials
Conditions for verification: Actual long-term follow-up, discontinuation, exposure and rare-event materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Supplementary
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N29 · Are the read summary and unread external materials distinguished?

Required materials and conditions: Preserved JSON, bibliography links, abstract, full-text, registration and planning status
Conditions for verification: Preserved JSON, bibliography links, abstract, full-text, registration and planning status; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

N30 · Are original verdict/history and candidate states separate from preparation?

Required materials and conditions: Korean/English, axes, dates, corrections, selected record link and preparation events
Conditions for verification: Korean/English, axes, dates, corrections, selected record link and preparation events; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Requirement and applicability: Required
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Link preserved methodological application records; no current clinical-content reassessment or external-link verification was performed.

What the statuses mean

Partly verified: Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.
Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete: Review of existing content incomplete
Met: Use only within the relevant conditions after existing content review; no automatic designation in this preparation
Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible: Not applied during this preparation because actual access was not tested
Not applicable: Use with a reason for non-applicability based on an explicit question boundary
Conflicting data: Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-12 · Public page/material version 1.0

The public page and data were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · What are the original selected question and subclaim verdict?

Current findings: The original subclaim concerns weight loss at 12 months, grade C, with the note that 52 weeks produced 2.14 kg more loss than 12 weeks. The parent has C with 50 points and separate axes.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The selected record has no score, status or axes. Parent values are not inserted as subclaim scores, and no new verdict is made.
Required materials and conditions: Original wording, subclaim grade/note and parent context for weight loss at 12 months
Materials to obtain first: Original selected subclaim and parent verdict
Further research: Record the original verdict, this preparation and existing-content review as separate events.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Original wording, subclaim grade/note and parent context for weight loss at 12 months; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N02 · Does the selected comparison concern durations of the same WW program?

Current findings: The parent outcome is greater weight loss at 12 months than the 12-week program. The comparator also received a 12-week referral to the same WW program and was an active control.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The 52- versus 12-week result is not recast as an effect versus no treatment or an effect of all commercial weight-management programs.
Required materials and conditions: Actual interventions and comparison questions for 52 weeks, 12 weeks and brief intervention
Materials to obtain first: Actual duration-specific referrals, program and brief-intervention specifications
Further research: Present duration comparison and comparisons with other controls as separate questions.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Actual interventions and comparison questions for 52 weeks, 12 weeks and brief intervention; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N03 · Who was recruited, and what is the applicability?

Current findings: The trial randomized 1,267 adults with BMI at least 28 in UK primary care.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Detailed age, diseases, selection and exclusion criteria are absent from the summary. Findings are not extended to all weights, ages, countries or diseases.
Required materials and conditions: Primary-care population eligibility, exclusions and baseline characteristics
Materials to obtain first: Eligibility, exclusion and baseline-characteristic tables
Further research: Present the recruited population and applicable question scope.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Primary-care population eligibility, exclusions and baseline characteristics; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N04 · What was the research identity of the 52-week intervention?

Current findings: The original intervention is the commercial WW weight-management program with one group meeting per week for 52 weeks. Its identity as provision of program access is retained.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: No recommended participation, diet or exercise instructions are written. Referral allocation is distinct from actual attendance/program content; details are unread.
Required materials and conditions: Program, meetings, referral and actual participation/exposure specifications
Materials to obtain first: Assigned program and attendance/content/exposure materials
Further research: Distinguish the intervention’s research identity from actual participation and exposure.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Program, meetings, referral and actual participation/exposure specifications; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N05 · Are the 12-week active control and brief-intervention group kept separate?

Current findings: Participants were allocated to brief intervention, 211, WW for 12 weeks, 528, or 52 weeks, 528. The 52- versus 12-week comparison concerns durations of the same program.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Brief intervention is not equated with the 12-week control, and effects of the two controls are not combined into the selected effect.
Required materials and conditions: Contents, denominators and effect of interest for each comparison group
Materials to obtain first: Three-group intervention specifications and analysis comparisons
Further research: Retain all three groups while displaying the selected two-group effect separately.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Contents, denominators and effect of interest for each comparison group; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N06 · Have allocation, concealment and masking details been read?

Current findings: The original evidence describes a three-arm randomized controlled trial. Parent bias B2 is historical verdict information.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Detailed allocation, concealment, weight-assessor masking and implementation records remain externally unread. The design label does not become new methodological certification.
Required materials and conditions: Randomization sequence, concealment and outcome-assessor masking materials
Materials to obtain first: Original allocation, concealment and assessor-role materials
Further research: Distinguish the design label from actual implementation details.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Randomization sequence, concealment and outcome-assessor masking materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N07 · Are randomized and measured 12-month denominators distinguished?

Current findings: The preserved summary records 1,267 allocated (211/528/528), with measured 12-month weight for 823/1,267 (65%).
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Group-specific measured/missing denominators are absent from the summary. The 823 are not assigned to a specific program group or described as all analyzed participants.
Required materials and conditions: Group-specific flow through allocation, follow-up, measurement and analysis
Materials to obtain first: Group-specific participant flow and measured/analysis-denominator tables
Further research: Present allocation, measurement and analysis denominators separately.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Group-specific flow through allocation, follow-up, measurement and analysis; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N08 · Are missing measurements and multiple imputation retained in interpretation?

Current findings: The original account of 35% missing measured 12-month weight and use of multiple imputation is retained.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Imputation models, missingness assumptions, group-specific attrition and sensitivity analyses are unread. Imputed results do not become actual measurements for everyone.
Required materials and conditions: Group-specific missingness reasons, imputation models/assumptions and sensitivity analysis
Materials to obtain first: Original imputation methods, missingness reasons and sensitivity-analysis materials
Further research: Present measured information separately from assumption-based analyses.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Group-specific missingness reasons, imputation models/assumptions and sensitivity analysis; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N09 · Are actual attendance, co-exposure and between-group changes verified?

Current findings: The original materials describe referral allocation and the research identity of one group meeting per week.
Verification status: Unverified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Attendance, adherence, cross-group use and other weight-management exposure are absent from the summary. The effect is not attributed solely to attendance time.
Required materials and conditions: Attendance, program use, accompanying management and group-change materials
Materials to obtain first: Duration-specific attendance, co-exposure and change records
Further research: Distinguish allocation effects from actual participation and accompanying exposure.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Attendance, program use, accompanying management and group-change materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N10 · Are weight measurement and timing specified?

Current findings: The primary endpoint was weight at one year; the evidence records weight at 12 months.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Detailed equipment, standardization, assessors and repeat-measurement handling remain externally unread. Other body measures are not treated as the same endpoint.
Required materials and conditions: One-year weight measurement procedure, equipment, units and timing
Materials to obtain first: 12-month measurement methods and original result tables
Further research: Present weight, measurement timing and units together.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: One-year weight measurement procedure, equipment, units and timing; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N11 · Are within-group changes and adjusted between-group differences separate values?

Current findings: At 12 months, weight change was -4.75 kg with 12 weeks and -6.76 kg with 52 weeks; the adjusted between-group difference was -2.14 kg.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Changes are not relabeled as final weights. The two changes are not subtracted to create a new effect or reconciled to the adjusted difference.
Required materials and conditions: Original within-group changes and adjusted between-group estimate
Materials to obtain first: Within-group changes, adjustment model and estimate tables
Further research: Display within-group changes separately alongside the adjusted between-group effect.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Original within-group changes and adjusted between-group estimate; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N12 · What are the 12-month between-group effect, interval and test?

Current findings: The recorded adjusted between-group difference is -2.14 kg, 95% CI -3.05 to -1.22, P<.0001.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Only the original effect/interval are retained; no new CI, relative weight loss or hypothetical numerical example is created.
Required materials and conditions: Directly reported difference, CI and P value for selected 52 versus 12 weeks
Materials to obtain first: Original selected-comparison results and analysis model
Further research: Present directly reported values with precision and applicability limits.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Directly reported difference, CI and P value for selected 52 versus 12 weeks; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N13 · Are the adjustment model and effect of interest known?

Current findings: The original account explicitly identifies an adjusted difference and multiple imputation for 35% missingness.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Exact covariates, estimand, analysis population and imputation linkage are unread. The estimate is not upgraded to a completer or actual-attendance effect.
Required materials and conditions: Covariates, analysis population, imputation and model specifications
Materials to obtain first: Original analysis model and effect-of-interest specifications
Further research: Distinguish allocation, participation and completer effects from imputed estimates.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Covariates, analysis population, imputation and model specifications; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N14 · Are the preceding and selected hierarchical comparisons distinguished?

Current findings: The summary reports that both program groups combined were first compared with brief intervention, passing with -2.71 kg, 95% CI -3.86 to -1.55, P<.0001, before comparing 52 with 12 weeks.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The -2.71 kg estimate is not copied as the selected 52- versus 12-week effect. The original planning document itself is unread.
Required materials and conditions: Original testing order, plans and results for preceding and subsequent comparisons
Materials to obtain first: Original hierarchical-testing plans and comparison-specific analyses
Further research: Link the preceding gatekeeping comparison separately from the selected effect.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Original testing order, plans and results for preceding and subsequent comparisons; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N15 · What is the reading scope for registration and plans?

Current findings: The account states registration preceded recruitment; the evidence identifier is ISRCTN82857232.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Registration originals, dates, change history and plans remain unread here. The source field name does not turn ISRCTN into an NCT registration.
Required materials and conditions: Registration identifier/timing, protocol, SAP and change history
Materials to obtain first: ISRCTN82857232 registration and planning documents
Further research: Distinguish the original identifier from actual material reading and prespecification.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Registration identifier/timing, protocol, SAP and change history; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N16 · Are sample-size assumptions distinguished from minimum clinical importance?

Current findings: The summary states that a sample of 1,200 assumed detection of a 1.3 kg difference, which was not a declared minimum clinically important difference.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The 1.3 kg assumption does not become an MCID, acceptance threshold or individual perceived-benefit threshold. Actual 1,267 allocation is distinguished from sample-size assumptions.
Required materials and conditions: Sample-size assumptions and declared importance criterion
Materials to obtain first: Original sample-size assumptions and clinical-importance criteria
Further research: Present detection assumptions separately from clinical importance.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Sample-size assumptions and declared importance criterion; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N17 · Are 12-month and 24-month effects distinguished?

Current findings: The recorded 24-month difference is -1.32 kg, 95% CI -2.46 to -0.18, P=.0231.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: 24-month values are not pooled with 12-month repeated measurements to calculate a new effect or counted as independent replication. The 24-month analysis denominator is unverified.
Required materials and conditions: Actual comparison, effect, denominator and subsequent exposure by time point
Materials to obtain first: Original 24-month results, follow-up, exposure and denominators
Further research: Display one-year and 24-month estimates separately.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Actual comparison, effect, denominator and subsequent exposure by time point; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N18 · Does 12-month superiority establish five-year maintenance?

Current findings: The original account records a null 52- versus 12-week result at five years: -0.80 kg, 95% CI -2.13 to 0.54.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: 12-month significance is not extended to sustained superiority. The five-year point estimate is not replaced with exact zero or equivalence.
Required materials and conditions: Direct five-year comparison and uncertainty in the same trial
Materials to obtain first: Original five-year follow-up report and time-specific comparisons
Further research: Distinguish short-term superiority from the long-term null result.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Direct five-year comparison and uncertainty in the same trial; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N19 · Are five-year measurements and follow-up denominators separate from 12 months?

Current findings: The long-term citation is the WRAP five-year follow-up. Measured 12-month weight in 823 and 35% missingness concern one year.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Five-year measurement, attrition, imputation and group denominators are absent from the summary. The 823, 65% and 35% are not reused as five-year values.
Required materials and conditions: Five-year follow-up, measurements, group denominators, missingness and analysis assumptions
Materials to obtain first: Five-year participant flow, analysis populations and missingness materials
Further research: Separate actual observed and analysis denominators by time point.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Five-year follow-up, measurements, group denominators, missingness and analysis assumptions; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R02

N20 · Is weight loss being extended to other clinical outcomes?

Current findings: The currently preserved evidence has weight at 12 months as its primary endpoint. The long-term citation title mentions effectiveness and cost-effectiveness.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Weight differences do not fill disease-prevention, mortality, quality-of-life or cost-effectiveness gaps. No such direct results, economic values or decisions are created.
Required materials and conditions: Direct outcomes for weight versus clinical events, function and quality of life
Materials to obtain first: Outcome-specific original clinical, functional and economic materials
Further research: Distinguish weight change from direct evidence for other outcomes.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Direct outcomes for weight versus clinical events, function and quality of life; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N21 · Are the main report, five-year follow-up and sibling sheets kept within the same trial?

Current findings: The 2017 WRAP main report and 2022 five-year follow-up are identified as reports of the same trial. The two sheets share parent summary 2964 and two subclaim records.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The two papers, sibling sheets, three groups, time points and registration are not totaled as independent trials/participants. Confirmed independent-trial/participant totals remain unrecorded.
Required materials and conditions: WRAP bibliography, registration, participants and follow-up relationships
Materials to obtain first: WRAP main report, registration and follow-up linkage materials
Further research: Distinguish report slots from trial and participant units.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: WRAP bibliography, registration, participants and follow-up relationships; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N22 · Are other independent replications and generalization materials available?

Current findings: The preserved summary identifies only the WRAP main report and same-trial long-term follow-up. Parent replication R1 is a historical label.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: No new independent-replication count, similar-program equivalence or effect in other service settings is established.
Required materials and conditions: Actual independent reports for the same comparison, population and duration
Materials to obtain first: Direct replication and setting-specific applicability materials for the same question
Further research: Distinguish follow-up in the same cohort from other independent replication.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Actual independent reports for the same comparison, population and duration; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N23 · Are consortium funding, industry funding and program access distinguished?

Current findings: Public/nonprofit consortium funding accompanied WW International industry-partner funding and program access. The UK MRC Industrial Collaboration Award relationship is retained.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Industry support is not removed because public/nonprofit funding was present. Contracts and analysis/writing/publication roles remain externally unread.
Required materials and conditions: Research funding, program support, contracts and sponsor-role disclosures
Materials to obtain first: Funding, program access and sponsor-role disclosures
Further research: Display public, nonprofit and industry funding separately from program support.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Research funding, program support, contracts and sponsor-role disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N24 · Are WW funding to authors’ institutions and employee authors distinguished?

Current findings: The account states that five authors disclosed WW research funding received by their institutions.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Institutional funding is not relabeled as five company-employee authors. Author names, additional COI and data rights are absent from the summary.
Required materials and conditions: Author-specific affiliations, contributions, institutional support and COI disclosures
Materials to obtain first: Author/institutional support, contribution and COI specifications
Further research: Distinguish institutional support from employment, analysis and publication roles.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Author-specific affiliations, contributions, institutional support and COI disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N25 · Are contracted analysis, medical writing, publication fees and program control known?

Current findings: The summary describes industry funding, program access and funding relationships involving authors’ institutions.
Verification status: Unverified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Nonmention of contracted analysis, medical writing, publication fees or data control does not certify all were absent.
Required materials and conditions: Industry-partner/researcher, analysis, writing and publication role disclosures
Materials to obtain first: Sponsor/author roles and data/publication-rights disclosures
Further research: Present reported support separately from unverified roles.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Industry-partner/researcher, analysis, writing and publication role disclosures; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N26 · What is the scope of the intervention-related adverse-event account?

Current findings: The summary states that the paper reported no intervention-related adverse events but did not provide a group-specific table of all adverse events.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The relationship-specific reporting account does not establish zero of all events, complete collection or confirmed safety.
Required materials and conditions: Event definitions, causal classification, collection and group-specific exposure denominators
Materials to obtain first: Group-specific all-event, collection, classification and exposure tables
Further research: Distinguish all events from intervention-related events.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Event definitions, causal classification, collection and group-specific exposure denominators; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N27 · Is equal safety between the two referral durations established?

Current findings: The preserved safety account states that without an all-event table by group, equal safety between the durations cannot be concluded.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Absent harms CI, events and denominators do not become an equivalence trial or proof of safety.
Required materials and conditions: Duration-specific harms comparisons, estimates, intervals and denominators
Materials to obtain first: Duration-specific harms, discontinuation and comparison intervals
Further research: Distinguish efficacy superiority from harms comparisons and equivalence.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Duration-specific harms comparisons, estimates, intervals and denominators; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01

N28 · Are separate long-term and rare-harm materials required?

Current findings: The main-report account describes no intervention-related adverse events and absence of an all-event table; the subsequent bibliography concerns five-year follow-up.
Verification status: Unverified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: Five-year weight results or parent Good safety do not fill long-term/rare-harm gaps.
Required materials and conditions: Actual long-term follow-up, discontinuation, exposure and rare-event materials
Materials to obtain first: Long-term harms, follow-up and exposure-denominator materials
Further research: Present long-term weight effects separately from long-term safety information.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Actual long-term follow-up, discontinuation, exposure and rare-event materials; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Supplementary condition showing harms/safety-material scope separately from efficacy
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N29 · Are the read summary and unread external materials distinguished?

Current findings: What was actually read was the complete preserved parent JSON summary. The main-report PubMed and five-year repository URLs are linked as in the originals.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: External links were not clicked and materials were not newly queried. A URL does not upgrade external reading, original acquisition or content-review status.
Required materials and conditions: Preserved JSON, bibliography links, abstract, full-text, registration and planning status
Materials to obtain first: Original paper, follow-up report, registration, protocol and SAP
Further research: Show summary reading separately from material-specific external nonreading
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Preserved JSON, bibliography links, abstract, full-text, registration and planning status; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02

N30 · Are original verdict/history and candidate states separate from preparation?

Current findings: Korean/English, original axes, 2026-08-26 reference date, empty corrections/deliberation and subclaims are retained in the complete summary. Original candidate pending/eligible states are preserved history.
Verification status: Partly verified
Materials actually read: Summary read; external materials unread
Why unverified: Preparation displays information, scope and unverified matters in the read preserved materials; this is not completed content review or a new clinical efficacy/harms verdict.
Reason for missing information: The reference date is not used as a current-review date; candidate values do not activate a review gate stopping preparation. Review remains incomplete, no new units are created and confirmed independence totals remain unrecorded.
Required materials and conditions: Korean/English, axes, dates, corrections, selected record link and preparation events
Materials to obtain first: Original summary, native selection and condition-freeze/application preparation events
Further research: Record original history, preparation and existing-content review as separate events.
Remaining uncertainty: External abstracts, full texts, registration, protocols and SAP remain unread; no content review, calculation or new query was performed in this preparation.
Conditions for verification: Korean/English, axes, dates, corrections, selected record link and preparation events; distinguish direct materials, denominators, scope and unverified matters without new effects, verdicts or independence certification.
Why this condition is needed: Preparation condition clearly showing required evidence, current materials and gaps for the selected question
Application exceptions: Retain original values/scope only; other groups, time points, outcomes or formulations do not fill unverified matters.
Referenced methods: Existing application conditions and preserved methodological links are retained for preparation; this does not indicate completed review of the whole definition.

Related sources R01 R02