Two-year caloric restriction × reduced PC PhenoAge and PC GrimAge: a checklist of measure-specific evidence gaps

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Comparative efficacyAre the original PC PhenoAge and PC GrimAge claim and subclaim assessment separated from the parent slowing context?Required	The original subclaim is 'Reduced PC PhenoAge and PC GrimAge', with grade D and a note that neither measure changed significantly. The parent overall assessment, including DunedinPACE, is C54 with Unknown safety. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The subclaim has no score, status or axes; parent values are not used to fill them. No new assessment is made.	Records of the subclaim's original wording, grade and note and the parent context	Connect additional original material for each measure separately to the subclaim question and parent context.
2	Partly verified	Full text not readStored summary read	N02 · Comparative efficacyDo the two PC measures concern healthy non-obese adults?Required	The original paper is a post hoc analysis of 220 healthy non-obese adults in CALERIE at three US sites. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Findings are not automatically extended to direct effects in aging-related disease, obesity, other ages or frail populations. Detailed eligibility and baseline values have not been read.	Eligibility, baseline condition, age, BMI and group denominators	Obtain original population and baseline characteristics and numbers analyzed for each measure.
3	Partly verified	Full text not readStored summary read	N03 · Comparative efficacyAre the 25% target and about 12% achieved restriction distinguished as study exposures?Required	The original target is recorded as 25%, with average achieved restriction of about 12%. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. These are historical study conditions rather than personal calorie or weight-loss targets. The two PC findings are not assumed to be effects of the target exposure.	Original plans, achieved restriction, duration, adherence and measurements	Obtain original exposure measurements, individual adherence, restriction achieved over time and support records.
4	Partly verified	Full text not readStored summary read	N04 · Comparative efficacyIs the actual comparison of control diets, support and concurrent changes available?Required	The parent's randomized two-year caloric-restriction context is preserved. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Detailed control diets, exposures, contact and support are absent from the original summary. Equivalent nutrient composition or weight changes are not invented.	Actual diets, contact, support and concurrent management by group	Obtain original intervention, control, support, achieved-exposure and concurrent-change material.
5	Partly verified	Full text not readStored summary read	N05 · Comparative efficacyAre 220 randomized participants and the 197-person DNA analysis time-specific PC denominators?Required	There were 220 participants randomized 2:1; the DNA analysis included 197 participants with baseline and at least one follow-up sample. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Group sizes are not calculated from 2:1 allocation. The 197 participants are not assumed to be the denominator for all PC outcomes at 12 or 24 months.	Group allocation, DNA samples and analysis denominators by measure and time	Obtain group samples and analysis flows and denominators by time and measure.
6	Partly verified	Full text not readStored summary read	N06 · Comparative efficacyAre gaps in DNA sample selection, missingness, follow-up and models preserved?Required	The original account requires baseline and at least one follow-up sample for DNA inclusion. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Group exclusions, time-specific missingness, ITT, data processing and sensitivity analyses have not been read. New attrition rates or differences are not calculated.	Missingness, selection, analysis populations, sensitivity analyses and models by measure	Obtain original DNA selection, missingness, models and sensitivity material.
7	Partly verified	Full text not readStored summary read	N07 · Comparative efficacyAre the definition, units and original individual effects of PC PhenoAge directly available?Required	PC PhenoAge is one of the three original measures and is recorded as not significantly changed. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The endpoints of the d −0.04 to 0.05 range in the original rationale are not assigned as a particular time-specific PC PhenoAge effect. Individual CIs, P values and unit details have not been read.	Definitions, units, time points, denominators, effects and intervals for individual measures	Obtain original PC PhenoAge definitions, effects, CIs, P values and denominators by time.
8	Partly verified	Full text not readStored summary read	N08 · Comparative efficacyAre the definition, units and original individual effects of PC GrimAge directly available?Required	PC GrimAge is also one of the three original measures and is recorded as not significantly changed. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The endpoints of the d range are not assigned as a particular PC GrimAge effect. Individual CIs, P values, denominators and algorithm definitions have not been read.	Definitions, units, time points, denominators, effects and intervals for individual measures	Obtain original PC GrimAge definitions, effects, CIs, P values and denominators by time.
9	Partly verified	Full text not readStored summary read	N09 · Comparative efficacyAre the d range and P threshold presented jointly for the two measures distinguished from individual values?Required	The original account describes the two PC measures as null, with d −0.04 to 0.05 and P>0.15. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The range is not converted into a new mean, point estimates for each measure, exact P values or CIs. Zero effects or equivalence are not certified.	Detailed tables of original effects, intervals and tests by measure and time	Obtain original tables of individual effects, CIs, tests, models and denominators.
10	Unverified	Full text not readStored summary read	N10 · Comparative efficacyAre PC outcomes at 12 and 24 months preserved separately by time?Required	The original rationale gives DunedinPACE results at 12 and 24 months specifically, but describes the two PC measures as null only within a summary range. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Time-specific DunedinPACE d values, CIs and P values are not copied as PC values. Individual time-specific PC values remain unverified.	PC values, changes, between-group effects and denominators at each time	Obtain original tables and analysis denominators for both PC measures at each time.
11	Partly verified	Full text not readStored summary read	N11 · Comparative efficacyHas the positive DunedinPACE signal been kept separate from PC reductions?Required	The original DunedinPACE signal is preserved: d=−0.29 (95% CI −0.45 to −0.13) at 12 months, d=−0.25 (−0.41 to −0.09) at 24 months, original P<0.003 and roughly 2~3% slowing. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. This measure's slowing is not used to fill in reductions in PC PhenoAge or PC GrimAge. A 24-month CI level or individual P values are not newly added.	Results, units, time points and direct original effects by measure	Connect original effects, intervals, time points and models separately by measure.
12	Partly verified	Full text not readStored summary read	N12 · Comparative efficacyDo the PC age measures and DunedinPACE pace measure quantify the same thing?Required	The original account separates three DNA-methylation clocks or measures and describes DunedinPACE as a surrogate pace-of-aging measure. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Pace changes, PC reductions and clinical aging itself are not combined as the same value. Exact measure-specific definitions, units and validation have not been read.	Purpose, definitions, units, validation and applicability of each measure	Obtain original methods, units and validation material separately for each measure.
13	Unverified	Full text not readStored summary read	N13 · Comparative efficacyAre DNA laboratory methods, batches, normalization and PC calculation directly preserved?Required	The design is a post hoc DNA-methylation analysis; the original account records laboratory analyst blinding. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. PC algorithm, measurement, batch and normalization details are not invented, and new PC scores are not calculated from original data.	Original methods for samples, platforms, batches, normalization and PC calculation	Obtain original laboratory, measure-calculation and data-processing methods.
14	Partly verified	Full text not readStored summary read	N14 · Comparative efficacyAre the post hoc analysis and the parent's prespecified clinical primary plan separated?Required	The paper is explicitly post hoc, and the original account states that this was not the parent's prespecified clinical primary endpoint. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The two PC measures are not newly designated as prespecified clinical coprimary endpoints. Registration and SAP remain unread in this production.	Original registration, protocol, SAP, analysis selection, changes and hierarchy	Obtain parent plans and records of post hoc measure selection, hierarchy and changes.
15	Partly verified	Full text not readStored summary read	N15 · Comparative efficacyAre the split findings across three key measures and plans for multiple time points and tests preserved?Required	The original assessment that only one of three measures was positive and the parent's split-key-measures flag set to true are preserved. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The original split-results axis is not converted into a prespecified clinical primary designation. Adjustments for nonsignificant PC findings or positive DunedinPACE findings are not invented.	Original plans for three measures, time points, effects of interest, multiplicity and selective reporting	Obtain tests and adjustments by measure and time, original outcome lists and selective-reporting records.
16	Partly verified	Full text not readStored summary read	N16 · Comparative efficacyAre null or nonsignificant findings distinguished from exclusion of a clinically important effect or equivalence?Required	The original account states that there was no clinical minimum-effect threshold or prespecified success boundary and records null findings for both PC measures. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. P>0.15 without individual CIs does not newly certify exclusion of all meaningful reductions or equivalence.	Individual CIs, validated thresholds and prespecified success boundaries	Obtain original CIs, clinical-importance validation and prespecified plans for each PC measure.
17	Partly verified	Full text not readStored summary read	N17 · Comparative efficacyAre blinding and allocation procedures recorded at their actual measure-specific scope?Required	The original Korean account says analysts were unaware of allocation; the English account specifies 'laboratory analysts blinded'. The 2:1 randomized design is preserved. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Participant, intervention-provider or all-analyst blinding and allocation concealment are not described as newly verified.	Parent allocation, laboratory analysts, statistical analysis and measurement methods	Obtain original allocation, laboratory and analyst roles and blinding procedures.
18	Unverified	Full text not readStored summary read	N18 · Comparative efficacyIs the relationship between achieved exposure, weight or nutrient changes and PC effects directly verified?Required	The original information that target and achieved average restriction differed is preserved. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. PC effects by achieved restriction, mechanisms and causal relationships with weight changes are not newly calculated or confirmed.	Achieved restriction, adherence, concurrent changes and prespecified mediation or effects of interest	Obtain original achieved exposure, adherence, concurrent changes, models and plans.
19	Unverified	Full text not readStored summary read	N19 · Comparative efficacyDo gaps remain concerning post-intervention persistence, later measures and mechanisms?Required	The original intervention lasted two years, and the stored summary has no quantitative post-intervention PC persistence effects. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Post-intervention PC reductions, rebound or all-mechanism effects are not invented.	Follow-up duration, measures, denominators, original effects and direct mechanism measurements	Obtain direct post-intervention measures, models, denominators and follow-up material.
20	Partly verified	Full text not readStored summary read	N20 · Comparative efficacyDo null PC findings establish null results for all clinical aging, disease or lifespan outcomes?Required	The original account states that reduced disease, disability or death was not measured and healthy lifespan was not answered. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Null PC findings are not recast as null clinical effects overall; the DunedinPACE signal is not recast as benefits for rejuvenation, lifespan or independent living.	Direct clinical endpoints, follow-up, events, denominators and effects	Direct events, long-term follow-up and original effects are needed for each clinical question.
21	Partly verified	Full text not readStored summary read	N21 · Comparative efficacyAre the same CALERIE report, measures and time points kept from being counted as new independent replication?Required	Both subclaim sheets share the same post hoc paper, 220 randomized participants and 197-person DNA data. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Different measures, time points or sheets are not summed as independent trials or new participants. Final unique trial, participant and independent counts remain unrecorded.	Relationships among the parent trial, post hoc report, same participants and sibling sheets	Connect additional reports through original trial identifiers while retaining same-population relationships.
22	Partly verified	Full text not readStored summary read	N22 · Comparative efficacyAre funding, DunedinPACE inventors and commercial licensing preserved alongside the PC findings?Required	Support from NIA, American Brain Foundation, CIHR and others, authorship by DunedinPACE inventors D.L. Corcoran and D.W. Belsky, and commercial licensing are preserved. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The same invention or licensing interests are not newly added for the PC measures. Product or service provision, employee affiliations and outside-analysis details have not been read.	Funding, invention, licensing, affiliations, provision and analysis roles	Obtain original funding, measure-related disclosures, affiliations, analysis and manuscript roles.
23	Partly verified	Full text not readStored summary read	N23 · Supplementary harm evidenceAre absent safety reporting in this analysis and parent-trial harms separated?Required	This post hoc analysis did not report safety as an endpoint, and original safety is Unknown. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Null PC findings or positive DunedinPACE findings are not used as evidence of safety. They are not extended to absence of all harms in the parent CALERIE trial.	Analysis-specific and parent-trial harm plans, collection, events by group and denominators	Obtain original parent-trial harm collection, events, exposure, discontinuation and denominators.
24	Unverified	Full text not readStored summary read	N24 · Supplementary harm evidenceWhat gaps concern achieved two-year exposure, rare harms, discontinuation and long-term follow-up?Required	The original account explicitly states that this analysis cannot determine harms of long-term caloric restriction. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Harm counts, rates, CIs or specific nutritional harms outside the original account are not invented. Null results for two measures are not assumed to mean no harms.	Direct harms by group exposure, severity, discontinuation and duration	Obtain original trial and follow-up harm, exposure, discontinuation and rare-event material.
25	Unverified	Full text not readStored summary read	N25 · Supplementary harm evidenceAre harm replication, applicability and instructions for other populations or dietary exposures distinguished?Required	The current material concerns historical two-year study conditions in healthy non-obese adults. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Effects or harms for other populations or dietary methods are not newly confirmed; personal calorie, diet, weight-loss or treatment guidance is not created.	Direct effects or harms and report relationships by population and exposure	Connect direct comparison and harm material for new populations or exposures separately.
26	Partly verified	Full text not readStored summary read	N26 · Comparative efficacyAre the stored summary and actual access to external abstracts, full text, registration and SAP distinguished?Required	The original PubMed link and NCT00427193 are preserved, and the entire parent summary was read for production. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. A registration URL is not newly constructed, and all external materials remain unread. Separate links, screens and content review were not checked during original production.	Original links, registration identifiers, preserved original material and material-specific access records	Connect provided original material with its actual material-specific access status.
27	Partly verified	Full text not readStored summary read	N27 · Comparative efficacyAre the reference date, Korean and English text, empty values, subclaim and parent values, and production status preserved?Supplementary	The 2026-08-26 reference date, empty correction and deliberation values, Korean and English text, parent C54, original axes and subclaim D are preserved. Original pending and production-eligible markers are historical. R01	Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The absent subclaim score is not filled in. The original content review remains incomplete; model, content and scope review activation and completion remain false, added assessment units are 0 and the final independent count is unrecorded.	Distinction among original text, assessment records, dates, corrections, candidate history and review status	Proposal: Reflect additional materials and decisions through preservation of original wording and separate events.

No items match your search or filter.

27 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-08-26
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Healthy non-obese adults in CALERIE; three US sites; detailed eligibility not read
Ingredient, formulation and route: Historical two-year caloric-restriction study intervention; not personal calorie, diet or weight-loss instructions
Dose: Original target of 25% and achieved average of about 12% preserved separately; individual and time-specific exposure details not read
Comparator: Parent randomized control group; specific control diet, support and concurrent management not read
Measured outcome: Selected reductions in PC PhenoAge and PC GrimAge; unverified measure-specific values and time points, and DunedinPACE preserved separately
Duration: Two-year study intervention; details of DunedinPACE at 12 and 24 months and time-specific PC outcomes unverified; post-intervention follow-up unverified
Questions outside this scope: Recasting a DNA measure as clinical rejuvenation, aging in general, disease, disability, death, lifespan or independent living; Treating target exposure and the achieved average as identical; Summing time points, measures, the 197-person DNA denominator or sibling sheets as new independent evidence; Personal calorie, dietary, weight-loss or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Waziry R, Ryan CP, Corcoran DL, et al. Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial. Nat Aging. 2023;3:248-257. PMID: 37118425.

PubMed

Material type: Post hoc DNA-analysis report from the parent randomized trial
Materials actually read: Summary read; external materials not read
Findings recorded in the stored summary: Only DunedinPACE changed: d=−0.29 at 12 months and d=−0.25 at 24 months; the other two clocks were null
Record level: Stored evidence-list and narrative summaries; not direct reading of the original paper or registration
Study overlap and independent replication: Post hoc DNA analysis of the CALERIE parent randomized trial; the two subclaim sheets, measures and time points are shared, rather than separate new trials. Family IDs connect relationships and do not certify unique trial counts; reports, time points, measures, sibling sheets and the same participants are not newly summed as independent evidence.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
local_summary	Original source link preserved	Summary read	Summary read	Preserved parent verdict summary
abstract	Original source link preserved	Not read	Not read	External material unread; a URL does not mean acquisition, reading or completed review
fulltext	No separate URL in the original material	Not read	Not read	External material unread; a URL does not mean acquisition, reading or completed review
registration	No separate URL in the original material	Not read	Not read	External material unread; a URL does not mean acquisition, reading or completed review
protocol_sap	No separate URL in the original material	Not read	Not read	External material unread; a URL does not mean acquisition, reading or completed review

Report counts versus independent study counts

Post hoc DNA analysis of the CALERIE parent randomized trial; the two subclaim sheets, measures and time points are shared, rather than separate new trials. Family IDs connect relationships and do not certify unique trial counts; reports, time points, measures, sibling sheets and the same participants are not newly summed as independent evidence.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Are the original PC PhenoAge and PC GrimAge claim and subclaim assessment separated from the parent slowing context?

Required materials and conditions: Records of the subclaim's original wording, grade and note and the parent context
Conditions for verification: Records of the subclaim's original wording, grade and note and the parent context
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N02 · Do the two PC measures concern healthy non-obese adults?

Required materials and conditions: Eligibility, baseline condition, age, BMI and group denominators
Conditions for verification: Eligibility, baseline condition, age, BMI and group denominators
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N03 · Are the 25% target and about 12% achieved restriction distinguished as study exposures?

Required materials and conditions: Original plans, achieved restriction, duration, adherence and measurements
Conditions for verification: Original plans, achieved restriction, duration, adherence and measurements
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N04 · Is the actual comparison of control diets, support and concurrent changes available?

Required materials and conditions: Actual diets, contact, support and concurrent management by group
Conditions for verification: Actual diets, contact, support and concurrent management by group
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N05 · Are 220 randomized participants and the 197-person DNA analysis time-specific PC denominators?

Required materials and conditions: Group allocation, DNA samples and analysis denominators by measure and time
Conditions for verification: Group allocation, DNA samples and analysis denominators by measure and time
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N06 · Are gaps in DNA sample selection, missingness, follow-up and models preserved?

Required materials and conditions: Missingness, selection, analysis populations, sensitivity analyses and models by measure
Conditions for verification: Missingness, selection, analysis populations, sensitivity analyses and models by measure
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N07 · Are the definition, units and original individual effects of PC PhenoAge directly available?

Required materials and conditions: Definitions, units, time points, denominators, effects and intervals for individual measures
Conditions for verification: Definitions, units, time points, denominators, effects and intervals for individual measures
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N08 · Are the definition, units and original individual effects of PC GrimAge directly available?

Required materials and conditions: Definitions, units, time points, denominators, effects and intervals for individual measures
Conditions for verification: Definitions, units, time points, denominators, effects and intervals for individual measures
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N09 · Are the d range and P threshold presented jointly for the two measures distinguished from individual values?

Required materials and conditions: Detailed tables of original effects, intervals and tests by measure and time
Conditions for verification: Detailed tables of original effects, intervals and tests by measure and time
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N10 · Are PC outcomes at 12 and 24 months preserved separately by time?

Required materials and conditions: PC values, changes, between-group effects and denominators at each time
Conditions for verification: PC values, changes, between-group effects and denominators at each time
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N11 · Has the positive DunedinPACE signal been kept separate from PC reductions?

Required materials and conditions: Results, units, time points and direct original effects by measure
Conditions for verification: Results, units, time points and direct original effects by measure
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N12 · Do the PC age measures and DunedinPACE pace measure quantify the same thing?

Required materials and conditions: Purpose, definitions, units, validation and applicability of each measure
Conditions for verification: Purpose, definitions, units, validation and applicability of each measure
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N13 · Are DNA laboratory methods, batches, normalization and PC calculation directly preserved?

Required materials and conditions: Original methods for samples, platforms, batches, normalization and PC calculation
Conditions for verification: Original methods for samples, platforms, batches, normalization and PC calculation
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N14 · Are the post hoc analysis and the parent's prespecified clinical primary plan separated?

Required materials and conditions: Original registration, protocol, SAP, analysis selection, changes and hierarchy
Conditions for verification: Original registration, protocol, SAP, analysis selection, changes and hierarchy
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N15 · Are the split findings across three key measures and plans for multiple time points and tests preserved?

Required materials and conditions: Original plans for three measures, time points, effects of interest, multiplicity and selective reporting
Conditions for verification: Original plans for three measures, time points, effects of interest, multiplicity and selective reporting
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N16 · Are null or nonsignificant findings distinguished from exclusion of a clinically important effect or equivalence?

Required materials and conditions: Individual CIs, validated thresholds and prespecified success boundaries
Conditions for verification: Individual CIs, validated thresholds and prespecified success boundaries
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N17 · Are blinding and allocation procedures recorded at their actual measure-specific scope?

Required materials and conditions: Parent allocation, laboratory analysts, statistical analysis and measurement methods
Conditions for verification: Parent allocation, laboratory analysts, statistical analysis and measurement methods
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N18 · Is the relationship between achieved exposure, weight or nutrient changes and PC effects directly verified?

Required materials and conditions: Achieved restriction, adherence, concurrent changes and prespecified mediation or effects of interest
Conditions for verification: Achieved restriction, adherence, concurrent changes and prespecified mediation or effects of interest
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N19 · Do gaps remain concerning post-intervention persistence, later measures and mechanisms?

Required materials and conditions: Follow-up duration, measures, denominators, original effects and direct mechanism measurements
Conditions for verification: Follow-up duration, measures, denominators, original effects and direct mechanism measurements
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N20 · Do null PC findings establish null results for all clinical aging, disease or lifespan outcomes?

Required materials and conditions: Direct clinical endpoints, follow-up, events, denominators and effects
Conditions for verification: Direct clinical endpoints, follow-up, events, denominators and effects
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N21 · Are the same CALERIE report, measures and time points kept from being counted as new independent replication?

Required materials and conditions: Relationships among the parent trial, post hoc report, same participants and sibling sheets
Conditions for verification: Relationships among the parent trial, post hoc report, same participants and sibling sheets
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N22 · Are funding, DunedinPACE inventors and commercial licensing preserved alongside the PC findings?

Required materials and conditions: Funding, invention, licensing, affiliations, provision and analysis roles
Conditions for verification: Funding, invention, licensing, affiliations, provision and analysis roles
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N23 · Are absent safety reporting in this analysis and parent-trial harms separated?

Required materials and conditions: Analysis-specific and parent-trial harm plans, collection, events by group and denominators
Conditions for verification: Analysis-specific and parent-trial harm plans, collection, events by group and denominators
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N24 · What gaps concern achieved two-year exposure, rare harms, discontinuation and long-term follow-up?

Required materials and conditions: Direct harms by group exposure, severity, discontinuation and duration
Conditions for verification: Direct harms by group exposure, severity, discontinuation and duration
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N25 · Are harm replication, applicability and instructions for other populations or dietary exposures distinguished?

Required materials and conditions: Direct effects or harms and report relationships by population and exposure
Conditions for verification: Direct effects or harms and report relationships by population and exposure
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N26 · Are the stored summary and actual access to external abstracts, full text, registration and SAP distinguished?

Required materials and conditions: Original links, registration identifiers, preserved original material and material-specific access records
Conditions for verification: Original links, registration identifiers, preserved original material and material-specific access records
Requirement and applicability: Required
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

N27 · Are the reference date, Korean and English text, empty values, subclaim and parent values, and production status preserved?

Required materials and conditions: Distinction among original text, assessment records, dates, corrections, candidate history and review status
Conditions for verification: Distinction among original text, assessment records, dates, corrections, candidate history and review status
Requirement and applicability: Supplementary
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Preserved methodology connections were reused for preparation. No new review of methodological content, reassessment or external-link checks were performed.

What the statuses mean

Partly verified: Some information exists in the preserved review summary; detailed original materials remain unverified. This does not certify a passed review or clinical efficacy.
Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety
Review incomplete: Review of existing content incomplete
Met: Use only within the relevant conditions after existing content review; no automatic designation in this preparation
Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings
Inaccessible: Not applied during this preparation because actual access was not tested
Not applicable: Use with a reason for non-applicability based on an explicit question boundary
Conflicting data: Judge after actual material comparison; review was not performed during this preparation
Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials

Change history

2026-10-11 · Public page/material version 1.0

Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Are the original PC PhenoAge and PC GrimAge claim and subclaim assessment separated from the parent slowing context?

Current findings: The original subclaim is 'Reduced PC PhenoAge and PC GrimAge', with grade D and a note that neither measure changed significantly. The parent overall assessment, including DunedinPACE, is C54 with Unknown safety.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The subclaim has no score, status or axes; parent values are not used to fill them. No new assessment is made.
Reason for missing information: The subclaim has no score, status or axes; parent values are not used to fill them. No new assessment is made.
Required materials and conditions: Records of the subclaim's original wording, grade and note and the parent context
Materials to obtain first: The subclaim has no score, status or axes; parent values are not used to fill them. No new assessment is made.
Further research: Connect additional original material for each measure separately to the subclaim question and parent context.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Records of the subclaim's original wording, grade and note and the parent context
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N02 · Do the two PC measures concern healthy non-obese adults?

Current findings: The original paper is a post hoc analysis of 220 healthy non-obese adults in CALERIE at three US sites.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Findings are not automatically extended to direct effects in aging-related disease, obesity, other ages or frail populations. Detailed eligibility and baseline values have not been read.
Reason for missing information: Findings are not automatically extended to direct effects in aging-related disease, obesity, other ages or frail populations. Detailed eligibility and baseline values have not been read.
Required materials and conditions: Eligibility, baseline condition, age, BMI and group denominators
Materials to obtain first: Findings are not automatically extended to direct effects in aging-related disease, obesity, other ages or frail populations. Detailed eligibility and baseline values have not been read.
Further research: Obtain original population and baseline characteristics and numbers analyzed for each measure.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Eligibility, baseline condition, age, BMI and group denominators
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N03 · Are the 25% target and about 12% achieved restriction distinguished as study exposures?

Current findings: The original target is recorded as 25%, with average achieved restriction of about 12%.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. These are historical study conditions rather than personal calorie or weight-loss targets. The two PC findings are not assumed to be effects of the target exposure.
Reason for missing information: These are historical study conditions rather than personal calorie or weight-loss targets. The two PC findings are not assumed to be effects of the target exposure.
Required materials and conditions: Original plans, achieved restriction, duration, adherence and measurements
Materials to obtain first: These are historical study conditions rather than personal calorie or weight-loss targets. The two PC findings are not assumed to be effects of the target exposure.
Further research: Obtain original exposure measurements, individual adherence, restriction achieved over time and support records.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Original plans, achieved restriction, duration, adherence and measurements
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N04 · Is the actual comparison of control diets, support and concurrent changes available?

Current findings: The parent's randomized two-year caloric-restriction context is preserved.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Detailed control diets, exposures, contact and support are absent from the original summary. Equivalent nutrient composition or weight changes are not invented.
Reason for missing information: Detailed control diets, exposures, contact and support are absent from the original summary. Equivalent nutrient composition or weight changes are not invented.
Required materials and conditions: Actual diets, contact, support and concurrent management by group
Materials to obtain first: Detailed control diets, exposures, contact and support are absent from the original summary. Equivalent nutrient composition or weight changes are not invented.
Further research: Obtain original intervention, control, support, achieved-exposure and concurrent-change material.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Actual diets, contact, support and concurrent management by group
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N05 · Are 220 randomized participants and the 197-person DNA analysis time-specific PC denominators?

Current findings: There were 220 participants randomized 2:1; the DNA analysis included 197 participants with baseline and at least one follow-up sample.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Group sizes are not calculated from 2:1 allocation. The 197 participants are not assumed to be the denominator for all PC outcomes at 12 or 24 months.
Reason for missing information: Group sizes are not calculated from 2:1 allocation. The 197 participants are not assumed to be the denominator for all PC outcomes at 12 or 24 months.
Required materials and conditions: Group allocation, DNA samples and analysis denominators by measure and time
Materials to obtain first: Group sizes are not calculated from 2:1 allocation. The 197 participants are not assumed to be the denominator for all PC outcomes at 12 or 24 months.
Further research: Obtain group samples and analysis flows and denominators by time and measure.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Group allocation, DNA samples and analysis denominators by measure and time
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N06 · Are gaps in DNA sample selection, missingness, follow-up and models preserved?

Current findings: The original account requires baseline and at least one follow-up sample for DNA inclusion.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Group exclusions, time-specific missingness, ITT, data processing and sensitivity analyses have not been read. New attrition rates or differences are not calculated.
Reason for missing information: Group exclusions, time-specific missingness, ITT, data processing and sensitivity analyses have not been read. New attrition rates or differences are not calculated.
Required materials and conditions: Missingness, selection, analysis populations, sensitivity analyses and models by measure
Materials to obtain first: Group exclusions, time-specific missingness, ITT, data processing and sensitivity analyses have not been read. New attrition rates or differences are not calculated.
Further research: Obtain original DNA selection, missingness, models and sensitivity material.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Missingness, selection, analysis populations, sensitivity analyses and models by measure
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N07 · Are the definition, units and original individual effects of PC PhenoAge directly available?

Current findings: PC PhenoAge is one of the three original measures and is recorded as not significantly changed.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The endpoints of the d −0.04 to 0.05 range in the original rationale are not assigned as a particular time-specific PC PhenoAge effect. Individual CIs, P values and unit details have not been read.
Reason for missing information: The endpoints of the d −0.04 to 0.05 range in the original rationale are not assigned as a particular time-specific PC PhenoAge effect. Individual CIs, P values and unit details have not been read.
Required materials and conditions: Definitions, units, time points, denominators, effects and intervals for individual measures
Materials to obtain first: The endpoints of the d −0.04 to 0.05 range in the original rationale are not assigned as a particular time-specific PC PhenoAge effect. Individual CIs, P values and unit details have not been read.
Further research: Obtain original PC PhenoAge definitions, effects, CIs, P values and denominators by time.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Definitions, units, time points, denominators, effects and intervals for individual measures
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N08 · Are the definition, units and original individual effects of PC GrimAge directly available?

Current findings: PC GrimAge is also one of the three original measures and is recorded as not significantly changed.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The endpoints of the d range are not assigned as a particular PC GrimAge effect. Individual CIs, P values, denominators and algorithm definitions have not been read.
Reason for missing information: The endpoints of the d range are not assigned as a particular PC GrimAge effect. Individual CIs, P values, denominators and algorithm definitions have not been read.
Required materials and conditions: Definitions, units, time points, denominators, effects and intervals for individual measures
Materials to obtain first: The endpoints of the d range are not assigned as a particular PC GrimAge effect. Individual CIs, P values, denominators and algorithm definitions have not been read.
Further research: Obtain original PC GrimAge definitions, effects, CIs, P values and denominators by time.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Definitions, units, time points, denominators, effects and intervals for individual measures
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N09 · Are the d range and P threshold presented jointly for the two measures distinguished from individual values?

Current findings: The original account describes the two PC measures as null, with d −0.04 to 0.05 and P>0.15.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The range is not converted into a new mean, point estimates for each measure, exact P values or CIs. Zero effects or equivalence are not certified.
Reason for missing information: The range is not converted into a new mean, point estimates for each measure, exact P values or CIs. Zero effects or equivalence are not certified.
Required materials and conditions: Detailed tables of original effects, intervals and tests by measure and time
Materials to obtain first: The range is not converted into a new mean, point estimates for each measure, exact P values or CIs. Zero effects or equivalence are not certified.
Further research: Obtain original tables of individual effects, CIs, tests, models and denominators.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Detailed tables of original effects, intervals and tests by measure and time
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N10 · Are PC outcomes at 12 and 24 months preserved separately by time?

Current findings: The original rationale gives DunedinPACE results at 12 and 24 months specifically, but describes the two PC measures as null only within a summary range.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Time-specific DunedinPACE d values, CIs and P values are not copied as PC values. Individual time-specific PC values remain unverified.
Reason for missing information: Time-specific DunedinPACE d values, CIs and P values are not copied as PC values. Individual time-specific PC values remain unverified.
Required materials and conditions: PC values, changes, between-group effects and denominators at each time
Materials to obtain first: Time-specific DunedinPACE d values, CIs and P values are not copied as PC values. Individual time-specific PC values remain unverified.
Further research: Obtain original tables and analysis denominators for both PC measures at each time.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: PC values, changes, between-group effects and denominators at each time
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N11 · Has the positive DunedinPACE signal been kept separate from PC reductions?

Current findings: The original DunedinPACE signal is preserved: d=−0.29 (95% CI −0.45 to −0.13) at 12 months, d=−0.25 (−0.41 to −0.09) at 24 months, original P<0.003 and roughly 2~3% slowing.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. This measure's slowing is not used to fill in reductions in PC PhenoAge or PC GrimAge. A 24-month CI level or individual P values are not newly added.
Reason for missing information: This measure's slowing is not used to fill in reductions in PC PhenoAge or PC GrimAge. A 24-month CI level or individual P values are not newly added.
Required materials and conditions: Results, units, time points and direct original effects by measure
Materials to obtain first: This measure's slowing is not used to fill in reductions in PC PhenoAge or PC GrimAge. A 24-month CI level or individual P values are not newly added.
Further research: Connect original effects, intervals, time points and models separately by measure.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Results, units, time points and direct original effects by measure
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N12 · Do the PC age measures and DunedinPACE pace measure quantify the same thing?

Current findings: The original account separates three DNA-methylation clocks or measures and describes DunedinPACE as a surrogate pace-of-aging measure.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Pace changes, PC reductions and clinical aging itself are not combined as the same value. Exact measure-specific definitions, units and validation have not been read.
Reason for missing information: Pace changes, PC reductions and clinical aging itself are not combined as the same value. Exact measure-specific definitions, units and validation have not been read.
Required materials and conditions: Purpose, definitions, units, validation and applicability of each measure
Materials to obtain first: Pace changes, PC reductions and clinical aging itself are not combined as the same value. Exact measure-specific definitions, units and validation have not been read.
Further research: Obtain original methods, units and validation material separately for each measure.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Purpose, definitions, units, validation and applicability of each measure
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N13 · Are DNA laboratory methods, batches, normalization and PC calculation directly preserved?

Current findings: The design is a post hoc DNA-methylation analysis; the original account records laboratory analyst blinding.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. PC algorithm, measurement, batch and normalization details are not invented, and new PC scores are not calculated from original data.
Reason for missing information: PC algorithm, measurement, batch and normalization details are not invented, and new PC scores are not calculated from original data.
Required materials and conditions: Original methods for samples, platforms, batches, normalization and PC calculation
Materials to obtain first: PC algorithm, measurement, batch and normalization details are not invented, and new PC scores are not calculated from original data.
Further research: Obtain original laboratory, measure-calculation and data-processing methods.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Original methods for samples, platforms, batches, normalization and PC calculation
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N14 · Are the post hoc analysis and the parent's prespecified clinical primary plan separated?

Current findings: The paper is explicitly post hoc, and the original account states that this was not the parent's prespecified clinical primary endpoint.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The two PC measures are not newly designated as prespecified clinical coprimary endpoints. Registration and SAP remain unread in this production.
Reason for missing information: The two PC measures are not newly designated as prespecified clinical coprimary endpoints. Registration and SAP remain unread in this production.
Required materials and conditions: Original registration, protocol, SAP, analysis selection, changes and hierarchy
Materials to obtain first: The two PC measures are not newly designated as prespecified clinical coprimary endpoints. Registration and SAP remain unread in this production.
Further research: Obtain parent plans and records of post hoc measure selection, hierarchy and changes.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Original registration, protocol, SAP, analysis selection, changes and hierarchy
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N15 · Are the split findings across three key measures and plans for multiple time points and tests preserved?

Current findings: The original assessment that only one of three measures was positive and the parent's split-key-measures flag set to true are preserved.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The original split-results axis is not converted into a prespecified clinical primary designation. Adjustments for nonsignificant PC findings or positive DunedinPACE findings are not invented.
Reason for missing information: The original split-results axis is not converted into a prespecified clinical primary designation. Adjustments for nonsignificant PC findings or positive DunedinPACE findings are not invented.
Required materials and conditions: Original plans for three measures, time points, effects of interest, multiplicity and selective reporting
Materials to obtain first: The original split-results axis is not converted into a prespecified clinical primary designation. Adjustments for nonsignificant PC findings or positive DunedinPACE findings are not invented.
Further research: Obtain tests and adjustments by measure and time, original outcome lists and selective-reporting records.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Original plans for three measures, time points, effects of interest, multiplicity and selective reporting
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N16 · Are null or nonsignificant findings distinguished from exclusion of a clinically important effect or equivalence?

Current findings: The original account states that there was no clinical minimum-effect threshold or prespecified success boundary and records null findings for both PC measures.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. P>0.15 without individual CIs does not newly certify exclusion of all meaningful reductions or equivalence.
Reason for missing information: P>0.15 without individual CIs does not newly certify exclusion of all meaningful reductions or equivalence.
Required materials and conditions: Individual CIs, validated thresholds and prespecified success boundaries
Materials to obtain first: P>0.15 without individual CIs does not newly certify exclusion of all meaningful reductions or equivalence.
Further research: Obtain original CIs, clinical-importance validation and prespecified plans for each PC measure.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Individual CIs, validated thresholds and prespecified success boundaries
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N17 · Are blinding and allocation procedures recorded at their actual measure-specific scope?

Current findings: The original Korean account says analysts were unaware of allocation; the English account specifies 'laboratory analysts blinded'. The 2:1 randomized design is preserved.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Participant, intervention-provider or all-analyst blinding and allocation concealment are not described as newly verified.
Reason for missing information: Participant, intervention-provider or all-analyst blinding and allocation concealment are not described as newly verified.
Required materials and conditions: Parent allocation, laboratory analysts, statistical analysis and measurement methods
Materials to obtain first: Participant, intervention-provider or all-analyst blinding and allocation concealment are not described as newly verified.
Further research: Obtain original allocation, laboratory and analyst roles and blinding procedures.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Parent allocation, laboratory analysts, statistical analysis and measurement methods
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N18 · Is the relationship between achieved exposure, weight or nutrient changes and PC effects directly verified?

Current findings: The original information that target and achieved average restriction differed is preserved.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. PC effects by achieved restriction, mechanisms and causal relationships with weight changes are not newly calculated or confirmed.
Reason for missing information: PC effects by achieved restriction, mechanisms and causal relationships with weight changes are not newly calculated or confirmed.
Required materials and conditions: Achieved restriction, adherence, concurrent changes and prespecified mediation or effects of interest
Materials to obtain first: PC effects by achieved restriction, mechanisms and causal relationships with weight changes are not newly calculated or confirmed.
Further research: Obtain original achieved exposure, adherence, concurrent changes, models and plans.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Achieved restriction, adherence, concurrent changes and prespecified mediation or effects of interest
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N19 · Do gaps remain concerning post-intervention persistence, later measures and mechanisms?

Current findings: The original intervention lasted two years, and the stored summary has no quantitative post-intervention PC persistence effects.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Post-intervention PC reductions, rebound or all-mechanism effects are not invented.
Reason for missing information: Post-intervention PC reductions, rebound or all-mechanism effects are not invented.
Required materials and conditions: Follow-up duration, measures, denominators, original effects and direct mechanism measurements
Materials to obtain first: Post-intervention PC reductions, rebound or all-mechanism effects are not invented.
Further research: Obtain direct post-intervention measures, models, denominators and follow-up material.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Follow-up duration, measures, denominators, original effects and direct mechanism measurements
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N20 · Do null PC findings establish null results for all clinical aging, disease or lifespan outcomes?

Current findings: The original account states that reduced disease, disability or death was not measured and healthy lifespan was not answered.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Null PC findings are not recast as null clinical effects overall; the DunedinPACE signal is not recast as benefits for rejuvenation, lifespan or independent living.
Reason for missing information: Null PC findings are not recast as null clinical effects overall; the DunedinPACE signal is not recast as benefits for rejuvenation, lifespan or independent living.
Required materials and conditions: Direct clinical endpoints, follow-up, events, denominators and effects
Materials to obtain first: Null PC findings are not recast as null clinical effects overall; the DunedinPACE signal is not recast as benefits for rejuvenation, lifespan or independent living.
Further research: Direct events, long-term follow-up and original effects are needed for each clinical question.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Direct clinical endpoints, follow-up, events, denominators and effects
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N21 · Are the same CALERIE report, measures and time points kept from being counted as new independent replication?

Current findings: Both subclaim sheets share the same post hoc paper, 220 randomized participants and 197-person DNA data.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Different measures, time points or sheets are not summed as independent trials or new participants. Final unique trial, participant and independent counts remain unrecorded.
Reason for missing information: Different measures, time points or sheets are not summed as independent trials or new participants. Final unique trial, participant and independent counts remain unrecorded.
Required materials and conditions: Relationships among the parent trial, post hoc report, same participants and sibling sheets
Materials to obtain first: Different measures, time points or sheets are not summed as independent trials or new participants. Final unique trial, participant and independent counts remain unrecorded.
Further research: Connect additional reports through original trial identifiers while retaining same-population relationships.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Relationships among the parent trial, post hoc report, same participants and sibling sheets
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N22 · Are funding, DunedinPACE inventors and commercial licensing preserved alongside the PC findings?

Current findings: Support from NIA, American Brain Foundation, CIHR and others, authorship by DunedinPACE inventors D.L. Corcoran and D.W. Belsky, and commercial licensing are preserved.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The same invention or licensing interests are not newly added for the PC measures. Product or service provision, employee affiliations and outside-analysis details have not been read.
Reason for missing information: The same invention or licensing interests are not newly added for the PC measures. Product or service provision, employee affiliations and outside-analysis details have not been read.
Required materials and conditions: Funding, invention, licensing, affiliations, provision and analysis roles
Materials to obtain first: The same invention or licensing interests are not newly added for the PC measures. Product or service provision, employee affiliations and outside-analysis details have not been read.
Further research: Obtain original funding, measure-related disclosures, affiliations, analysis and manuscript roles.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Funding, invention, licensing, affiliations, provision and analysis roles
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N23 · Are absent safety reporting in this analysis and parent-trial harms separated?

Current findings: This post hoc analysis did not report safety as an endpoint, and original safety is Unknown.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Null PC findings or positive DunedinPACE findings are not used as evidence of safety. They are not extended to absence of all harms in the parent CALERIE trial.
Reason for missing information: Null PC findings or positive DunedinPACE findings are not used as evidence of safety. They are not extended to absence of all harms in the parent CALERIE trial.
Required materials and conditions: Analysis-specific and parent-trial harm plans, collection, events by group and denominators
Materials to obtain first: Null PC findings or positive DunedinPACE findings are not used as evidence of safety. They are not extended to absence of all harms in the parent CALERIE trial.
Further research: Obtain original parent-trial harm collection, events, exposure, discontinuation and denominators.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Analysis-specific and parent-trial harm plans, collection, events by group and denominators
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N24 · What gaps concern achieved two-year exposure, rare harms, discontinuation and long-term follow-up?

Current findings: The original account explicitly states that this analysis cannot determine harms of long-term caloric restriction.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Harm counts, rates, CIs or specific nutritional harms outside the original account are not invented. Null results for two measures are not assumed to mean no harms.
Reason for missing information: Harm counts, rates, CIs or specific nutritional harms outside the original account are not invented. Null results for two measures are not assumed to mean no harms.
Required materials and conditions: Direct harms by group exposure, severity, discontinuation and duration
Materials to obtain first: Harm counts, rates, CIs or specific nutritional harms outside the original account are not invented. Null results for two measures are not assumed to mean no harms.
Further research: Obtain original trial and follow-up harm, exposure, discontinuation and rare-event material.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Direct harms by group exposure, severity, discontinuation and duration
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N25 · Are harm replication, applicability and instructions for other populations or dietary exposures distinguished?

Current findings: The current material concerns historical two-year study conditions in healthy non-obese adults.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. Effects or harms for other populations or dietary methods are not newly confirmed; personal calorie, diet, weight-loss or treatment guidance is not created.
Reason for missing information: Effects or harms for other populations or dietary methods are not newly confirmed; personal calorie, diet, weight-loss or treatment guidance is not created.
Required materials and conditions: Direct effects or harms and report relationships by population and exposure
Materials to obtain first: Effects or harms for other populations or dietary methods are not newly confirmed; personal calorie, diet, weight-loss or treatment guidance is not created.
Further research: Connect direct comparison and harm material for new populations or exposures separately.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Direct effects or harms and report relationships by population and exposure
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N26 · Are the stored summary and actual access to external abstracts, full text, registration and SAP distinguished?

Current findings: The original PubMed link and NCT00427193 are preserved, and the entire parent summary was read for production.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. A registration URL is not newly constructed, and all external materials remain unread. Separate links, screens and content review were not checked during original production.
Reason for missing information: A registration URL is not newly constructed, and all external materials remain unread. Separate links, screens and content review were not checked during original production.
Required materials and conditions: Original links, registration identifiers, preserved original material and material-specific access records
Materials to obtain first: A registration URL is not newly constructed, and all external materials remain unread. Separate links, screens and content review were not checked during original production.
Further research: Connect provided original material with its actual material-specific access status.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Original links, registration identifiers, preserved original material and material-specific access records
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01

N27 · Are the reference date, Korean and English text, empty values, subclaim and parent values, and production status preserved?

Current findings: The 2026-08-26 reference date, empty correction and deliberation values, Korean and English text, parent C54, original axes and subclaim D are preserved. Original pending and production-eligible markers are historical.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Only the relevant information from the stored summary is recorded. Detailed original materials have not been read, and the original content review remains incomplete. The absent subclaim score is not filled in. The original content review remains incomplete; model, content and scope review activation and completion remain false, added assessment units are 0 and the final independent count is unrecorded.
Reason for missing information: The absent subclaim score is not filled in. The original content review remains incomplete; model, content and scope review activation and completion remain false, added assessment units are 0 and the final independent count is unrecorded.
Required materials and conditions: Distinction among original text, assessment records, dates, corrections, candidate history and review status
Materials to obtain first: The absent subclaim score is not filled in. The original content review remains incomplete; model, content and scope review activation and completion remain false, added assessment units are 0 and the final independent count is unrecorded.
Further research: Proposal: Reflect additional materials and decisions through preservation of original wording and separate events.
Remaining uncertainty: Unread/unverified does not mean zero effect, zero events, safety or new clinical certification.
Conditions for verification: Distinction among original text, assessment records, dates, corrections, candidate history and review status
Why this condition is needed: An individual condition for recording the selected measure, time, original values and applicability limits
Application exceptions: Unread external materials, other measures or out-of-scope outcomes do not establish that a condition is met, an effect is zero or safety is established.
Referenced methods: Reduced PC PhenoAge and PC GrimAge

Related sources R01