F-ACP dental mousse × Prevention of incident caries evidence sheet

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Efficacy comparison and presentation of stored materialWhich existing values are recorded for the caries-prevention question?Required	The selected existing question is 'prevention of incident caries', with original grade ? and note 'not measured'. Parent C50, Good and S/R1/I1/E+/B2 are context from the existing white-spot remineralization verdict; subclaim score, status and axes are absent. S01	Record from the stored summary. Some information is in the stored summary. No new caries-prevention grade/effect is created and parent values are not inherited. Review of the existing content remains incomplete.	Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes	Proposed follow-up material linking "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" as a separate item; no new investigation, calculation or trial is performed in this work.
2	Unverified	Full text not readStored summary read	N02 · Efficacy comparison and presentation of stored materialWas incident caries actually measured?Required	The existing note and counterview say reductions in new caries/filling treatment were not measured. This is not changed into 0 events, confirmed prevention or a numerical finding of no effect. S01	Record from the stored summary. Currently needed information is unverified. Direct caries definitions, events/denominators, observation windows and between-group effects/intervals are absent or unverified. Review of the existing content remains incomplete.	Distinguish incident caries/new clinical events from existing lesion scores	Proposed follow-up material linking "Distinguish incident caries/new clinical events from existing lesion scores" as a separate item; no new investigation, calculation or trial is performed in this work.
3	Partly verified	Full text not readStored summary read	N03 · Efficacy comparison and presentation of stored materialIs existing white-spot ICDAS change the same as prevention of new caries?Required	The original endpoint is the six-month ICDAS white-spot score, where higher is worse. Decreases in existing lesion scores are not transferred into incident-caries rates, fillings/pain or improved daily functioning. S01	Record from the stored summary. Some information is in the stored summary. New lesion/caries events, individual links to progression/recovery of existing lesions and clinical-event results remain unverified. Review of the existing content remains incomplete.	Existing lesions/visible remineralization, ICDAS and new events	Proposed follow-up material linking "Existing lesions/visible remineralization, ICDAS and new events" as a separate item; no new investigation, calculation or trial is performed in this work.
4	Partly verified	Full text not readStored summary read	N04 · Efficacy comparison and presentation of stored materialWhat outcome scope do ICDAS change values and P describe?Required	The original ICDAS reduction of 0.80 versus 0.39 points, with between-group P=.003, is the original lesion-score result. It is not changed into a caries-prevention rate, independent-living/patient responder proportion or new between-group difference/CI. S01	Record from the stored summary. Some information is in the stored summary. Group/lesion denominators, models, exact CIs and prespecified importance remain unverified. Review of the existing content remains incomplete.	Original 0.80/0.39 points, P=.003 and lower-is-better direction	Proposed follow-up material linking "Original 0.80/0.39 points, P=.003 and lower-is-better direction" as a separate item; no new investigation, calculation or trial is performed in this work.
5	Partly verified	Full text not readStored summary read	N05 · Efficacy comparison and presentation of stored materialHow are baseline/six-month scores and the original change difference retained?Required	The existing Korean verdict rationale's mousse 1.80→1.00, control 1.92→1.53 and change difference of 0.41 points are retained. No new reductions/differences are calculated from scores or converted into caries incidence. S01	Record from the stored summary. Some information is in the stored summary. Analysis populations, adjustment/rounding, intervals and scale aggregation details for scores/change differences remain unverified. Review of the existing content remains incomplete.	Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference	Proposed follow-up material linking "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" as a separate item; no new investigation, calculation or trial is performed in this work.
6	Unverified	Full text not readStored summary read	N06 · Efficacy comparison and presentation of stored materialDoes a clinically important minimum difference mean caries prevention?Required	Statistical ICDAS change and original parent C50 are historical surrogate-outcome context. Neither 0.41 points nor P is used as a prespecified important difference, new caries-prevention effect or individual target. S01	Record from the stored summary. Currently needed information is unverified. Prespecified ICDAS importance, between-group CIs and validated links to clinical events remain unverified. Review of the existing content remains incomplete.	Distinguish lesion-score importance, direct clinical events and between-group intervals	Proposed follow-up material linking "Distinguish lesion-score importance, direct clinical events and between-group intervals" as a separate item; no new investigation, calculation or trial is performed in this work.
7	Unverified	Full text not readStored summary read	N07 · Efficacy comparison and presentation of stored materialWere filling treatment, pain or oral daily-life outcomes reported?Required	The existing counterview records that reduced filling treatment was not measured. Wording that visible remineralization may be useful is not turned into numerical pain, chewing/daily-life improvement or actual treatment reduction. S01	Record from the stored summary. Currently needed information is unverified. Direct filling/treatment, pain/oral daily-life scales, denominators/periods and between-group values remain unverified. Review of the existing content remains incomplete.	Filling treatment/oral function, appearance assessment and new clinical outcomes	Proposed follow-up material linking "Filling treatment/oral function, appearance assessment and new clinical outcomes" as a separate item; no new investigation, calculation or trial is performed in this work.
8	Partly verified	Full text not readStored summary read	N08 · Efficacy comparison and presentation of stored materialWhich patients after orthodontic treatment were included?Required	The original population has white spots after orthodontic treatment, and the existing English research account describes adolescents. This is not extended to all ages/teeth, general caries prevention or populations with other conditions. S01	Record from the stored summary. Some information is in the stored summary. Exact ages, eligibility, orthodontic/baseline lesions, oral risk, comorbidities and recruitment conditions remain unverified. Review of the existing content remains incomplete.	Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope	Proposed follow-up material linking "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" as a separate item; no new investigation, calculation or trial is performed in this work.
9	Partly verified	Full text not readStored summary read	N09 · Efficacy comparison and presentation of stored materialAre the original F-ACP components the same as other product families?Required	Original F-ACP is an amorphous calcium-phosphate complex containing fluoride and carbonate. Fluoride/CPP-ACP in the original product-distribution wording is not reused as the same composition or preventive effect as this F-ACP. S01	Record from the stored summary. Some information is in the stored summary. Exact concentrations, product identity, lots/manufacturing, formulation equivalence and direct material for other products remain unverified. Review of the existing content remains incomplete.	Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products	Proposed follow-up material linking "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" as a separate item; no new investigation, calculation or trial is performed in this work.
10	Partly verified	Full text not readStored summary read	N10 · Efficacy comparison and presentation of stored materialWhat historical research conditions did the Essix retainer and six-month exposure describe?Required	The original trial applied mousse in an Essix retainer for six months. This exposure is not changed into amounts/frequency, implementation/suitability instructions or product recommendations. S01	Record from the stored summary. Some information is in the stored summary. Actual amounts/frequency, adherence/crossover, group exposure/concomitant care and control-management details remain unverified. Review of the existing content remains incomplete.	Original mousse in a retainer, actual exposure/adherence and control	Proposed follow-up material linking "Original mousse in a retainer, actual exposure/adherence and control" as a separate item; no new investigation, calculation or trial is performed in this work.
11	Unverified	Full text not readStored summary read	N11 · Efficacy comparison and presentation of stored materialWhat did the control group receive?Required	The original material contains control scores and a randomized controlled design, but absent exact control composition, appliance or oral care is not filled in. No treatment, appliance alone or an equivalent-fluoride control is not assumed. S01	Record from the stored summary. Currently needed information is unverified. Control formulations, common/group care, fluoride/toothpaste/other exposures and blinding remain unverified. Review of the existing content remains incomplete.	Mousse-control composition/appliance, common care and placebo definition	Proposed follow-up material linking "Mousse-control composition/appliance, common care and placebo definition" as a separate item; no new investigation, calculation or trial is performed in this work.
12	Partly verified	Full text not readStored summary read	N12 · Efficacy comparison and presentation of stored materialWhat is known about allocation and assessor blinding in the randomized design?Required	The original is a randomized controlled trial. Its original B2 axis or randomized label is not inherited as verification of allocation concealment, patient/assessor blinding or clinical caries-event adjudication. S01	Record from the stored summary. Some information is in the stored summary. Allocation/concealment, assessors, ICDAS measurement/photographs and blinding/awareness details remain unverified. Review of the existing content remains incomplete.	Allocation-sequence generation/concealment and measurement of ICDAS/caries events	Proposed follow-up material linking "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" as a separate item; no new investigation, calculation or trial is performed in this work.
13	Partly verified	Full text not readStored summary read	N13 · Efficacy comparison and presentation of stored materialWhat are the denominators of 106 randomized, 91 completers and 52/39?Required	106 randomized, 91 completers (mousse 52/control 39) and original attrition of 14.2% are retained. No new dropout counts/rates, caries-observed participants per group or event denominators are calculated. S01	Record from the stored summary. Some information is in the stored summary. Group follow-up, exclusions, dropout reasons, unmeasured clinical events and missing-data responses remain unverified. Review of the existing content remains incomplete.	Distinguish randomized/completer populations, group denominators and original 14.2% attrition	Proposed follow-up material linking "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" as a separate item; no new investigation, calculation or trial is performed in this work.
14	Partly verified	Full text not readStored summary read	N14 · Efficacy comparison and presentation of stored materialCan completer analysis describe effects in everyone randomized?Required	The original account describes 91/106 completer analysis as a limitation. Completer ICDAS values are not extended to caries-prevention effects in all 106 participants, no missing data or complete follow-up. S01	Record from the stored summary. Some information is in the stored summary. ITT/missing-data handling, sensitivity analyses, discontinuers' outcomes and prespecified plans remain unverified. Review of the existing content remains incomplete.	Scope of original completers, ITT/missing-data plans and baseline/within-group selection	Proposed follow-up material linking "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" as a separate item; no new investigation, calculation or trial is performed in this work.
15	Partly verified	Full text not readStored summary read	N15 · Efficacy comparison and presentation of stored materialAre people, teeth, lesions and repeated measurements the same units?Required	Original 106/91 and 52/39 are person denominators. How ICDAS was aggregated by tooth/lesion is unknown; each tooth/time point is not counted as a new participant/independent trial. S01	Record from the stored summary. Some information is in the stored summary. Lesion/tooth counts, within-person correlation, measurement/analysis models and group/time-point denominators remain unverified. Review of the existing content remains incomplete.	Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations	Proposed follow-up material linking "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" as a separate item; no new investigation, calculation or trial is performed in this work.
16	Unverified	Full text not readStored summary read	N16 · Efficacy comparison and presentation of stored materialWhat are the actual observation windows for six-month ICDAS and caries incidence?Required	The original trial period/ICDAS assessment is six months. It is not labeled as 0 caries events or prevention during that period, persistence afterward or confirmed long-term prevention. S01	Record from the stored summary. Currently needed information is unverified. Caries observation/adjudication windows, long-term follow-up, events/missing data and periods after exposure ends remain unverified. Review of the existing content remains incomplete.	Original six-month surrogate outcome and clinical-event periods/follow-up	Proposed follow-up material linking "Original six-month surrogate outcome and clinical-event periods/follow-up" as a separate item; no new investigation, calculation or trial is performed in this work.
17	Partly verified	Full text not readStored summary read	N17 · Efficacy comparison and presentation of stored materialWhat prespecified endpoint hierarchy included ICDAS and caries events?Required	The existing evidence-list endpoint is six-month ICDAS. Unmeasured caries events are not turned into a primary time point, confirmatory endpoint, prespecified comparison or responder analysis. S01	Record from the stored summary. Some information is in the stored summary. Protocols/SAPs, score/clinical-event plans, multiplicity and prespecified importance remain unverified. Review of the existing content remains incomplete.	Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity	Proposed follow-up material linking "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" as a separate item; no new investigation, calculation or trial is performed in this work.
18	Partly verified	Full text not readStored summary read	N18 · Efficacy comparison and presentation of stored materialAre the same report, sibling remineralization question and population kept separate from independent totals?Required	The parent/sibling ICDAS question and this caries-prevention question share the same Ciribè2024 report/population. Teeth/lesions, time points, scores/safety and the two questions are not added as new independent trials or total participants. S01	Record from the stored summary. Some information is in the stored summary. Unique clinical trial/participant and independent-replication totals have not been verified and are not recorded. Review of the existing content remains incomplete.	Ciribè2024, 106/91 participants and shared lesion/caries questions	Proposed follow-up material linking "Ciribè2024, 106/91 participants and shared lesion/caries questions" as a separate item; no new investigation, calculation or trial is performed in this work.
19	Partly verified	Full text not readStored summary read	N19 · Efficacy comparison and presentation of stored materialAre no external funding and unverified product provision/COI the same?Required	The original funding account says no external funding was received and product-provision wording was not identified in publicly checked COI/acknowledgment text. External full text was not read in this work; this is not changed into no free product support or no company, employee or COI involvement. S01	Record from the stored summary. Some information is in the stored summary. Institutional funding, products/manufacturers, employee authors, research/writing contributions, COI and supply agreements remain unverified. Review of the existing content remains incomplete.	Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles	Proposed follow-up material linking "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" as a separate item; no new investigation, calculation or trial is performed in this work.
20	Partly verified	Full text not readStored summary read	N20 · Efficacy comparison and presentation of stored materialDoes 'registration not identified' verify actual absence?Required	The original registration-identifier record says 'not identified'; the actual identifier remains unrecorded. This is not changed into a confirmed number, absence of registration or absence of a prespecified caries plan. S01	Record from the stored summary. Some information is in the stored summary. Registration texts/changes, protocols/SAPs and endpoint/missing-data plans have not been read or accessed. Review of the existing content remains incomplete.	Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP	Proposed follow-up material linking "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" as a separate item; no new investigation, calculation or trial is performed in this work.
21	Partly verified	Full text not readStored summary read	N21 · Harm-information gaps supplementing the efficacy tableWhat collection scope underlies six-month non-reporting of adverse effects?Supplementary	The original safety wording says no adverse effects were reported by patients or caregivers over six months. The original Good label is not extended to overall zero risk, all patients, other products, long-term safety or use recommendations. S01	Record from the stored summary. Some information is in the stored summary. Collection/questions, safety denominators, discontinuers/exposure, verification, severity/CIs and long-term/vulnerable-group harms remain unverified. Review of the existing content remains incomplete.	Patient/caregiver reports, denominators/time and distinction from zero risk	Proposed follow-up material linking "Patient/caregiver reports, denominators/time and distinction from zero risk" as a separate item; no new investigation, calculation or trial is performed in this work.
22	Partly verified	Full text not readStored summary read	N22 · Efficacy comparison and presentation of stored materialDo sales/recommendation or other-product/population statements establish caries prevention?Required	The original domestic distribution/recommendation wording is retained in the complete existing review summary. No new verification of current sales/recommendations, effects of all CPP-ACP/fluoride products or guidance on product selection, use, suitability, prevention or treatment is written. S01	Record from the stored summary. Some information is in the stored summary. New verification of other compositions/populations, long-term caries/daily-life clinical outcomes and current distribution is outside scope or unverified. Review of the existing content remains incomplete.	Original distribution history, this F-ACP surrogate outcome and direct material outside the scope	Proposed follow-up material linking "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" as a separate item; no new investigation, calculation or trial is performed in this work.
23	Partly verified	Full text not readStored summary read	N23 · Efficacy comparison and presentation of stored materialWhat was actually read from the stored summary, external papers and linked material?Required	The complete stored summary was read for production and labeled 'summary read', with the original URL retained. External papers, registration, plans and COI material remain 'not read'; past review descriptions/bibliography alone do not raise the reading status in this work. S01	Record from the stored summary. Some information is in the stored summary. External access, abstracts/full text, source comparison and external link/click tests were not performed. Review of the existing content remains incomplete.	Stored summary, PMID38927409 URL and unread registration/plans/COI	Proposed follow-up material linking "Stored summary, PMID38927409 URL and unread registration/plans/COI" as a separate item; no new investigation, calculation or trial is performed in this work.
24	Partly verified	Full text not readStored summary read	N24 · Efficacy comparison and presentation of stored materialHow are existing Korean/English texts, grade ?/C50, dates, corrections and empty values retained?Required	The complete review summary's Korean/English texts, parent C50/Good, unrecorded precision/false, empty corrections/deliberation and 2026-08-26 are retained. Selected grade ?/note and absent score/status/axes are distinguished from original limitation checks/cross-check history. S01	Record from the stored summary. Some information is in the stored summary. No source/translation review, new verdict/correction or external update was performed in this existing record. Review of the existing content remains incomplete.	Selected grade ?/note, parent C50/Good, null/false and 2026-08-26	Proposed follow-up material linking "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" as a separate item; no new investigation, calculation or trial is performed in this work.
25	Partly verified	Full text not readStored summary read	N25 · Efficacy comparison and presentation of stored materialHow are condition preservation, case production and content review distinguished?Required	Condition preservation, freezing, application, case production and content review are separate records. Review of the existing content is incomplete; record counts are not totals of unique clinical trials/participants. S01	Record from the stored summary. Some information is in the stored summary. Review of the existing content is incomplete and clinical source material was not newly verified. Review of the existing content remains incomplete.	Condition preservation, freezing, application, case production and incomplete content review	Proposed follow-up material linking "Condition preservation, freezing, application, case production and incomplete content review" as a separate item; no new investigation, calculation or trial is performed in this work.

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25 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-08-26
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Patients with post-orthodontic white spots; distinguish the original English description of adolescents and 106 randomized/91 completers (52/39) from the unverified caries denominator
Ingredient, formulation and route: Historical research exposure to F-ACP dental mousse in an Essix retainer for six months; this is not product-use guidance
Dose: Not recorded
Comparator: Original control scores and randomized design; exact control composition, concomitant care and appliance conditions remain unverified
Measured outcome: Selected prevention of new caries; original grade ? and note 'not measured'; six-month ICDAS change is surrogate-outcome context
Duration: Original six-month lesion scores; caries-event observation windows and long-term direct outcomes remain unverified
Questions outside this scope: Reusing existing ICDAS scores/visible remineralization, P=.003 and the .41 difference as effects on incident caries, fillings or daily-life outcomes; Filling the unmeasured-caries grade ? and note with 0 events, zero effect, confirmed prevention or a new grade/score; Calculating new differences, rates, CIs, individual targets or important differences from baseline 1.80/1.92, final 1.00/1.53 and .80/.39/.41; Calculating new dropout counts/rates, caries/lesion/safety denominators or remaining populations from 106/91/52/39 and the original 14.2%; Adding people, teeth, lesions, repeated time points, parent/sibling questions or one report as new independent trials/participants; Filling an unclear original comparator with no treatment, appliance alone, an equivalent-fluoride control, concomitant care or blinding; Reusing the F-ACP fluoride/carbonate complex as equivalent composition or caries effects for all CPP-ACP/fluoride products; Changing the original no-external-funding statement and unidentified product provision in the publicly checked scope into no free products, no employee involvement/COI or new independence certification; Reusing six-month non-reporting of adverse effects by patients/caregivers or the Good label as zero risk, long-term safety, safety for all patients or product safety; Using original distribution/recommendation history as current sales/policy verification, product choice, amount, frequency, suitability or caries-prevention/treatment guidance; Extending six-month surrogate findings from one completer trial into persistence after exposure or long-term clinical effects on caries/daily life; Inheriting parent C50/original axes, past cross-checks, limitation checks or full-text review as subclaim values, QA in this work or external reading; New searches/APIs, numerical calculations, invented numbers, new effects/CIs/grades, independence certification or guidance on product/treatment selection, use, suitability or implementation

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Ciribè et al. 2024

PubMed

Material type: Randomized controlled trial
Materials actually read: Summary read; external material unread
Findings recorded in the stored summary: The original subclaim note says prevention of incident caries was not measured. Existing ICDAS reductions of .80 versus .39/P=.003, original baseline/final scores and the .41 difference are separate; they are not clinical caries, filling or daily-life outcomes, or 0 incident events. No external funding, unidentified product provision and six-month non-reporting of adverse effects by patients/caregivers are history within the original public review scope; they are not inherited as full-text, COI or safety verification in this work. No new calculations, effects, CIs, grades or independence certification were made.
Record level: Outcome wording in the stored summary
Study overlap and independent replication: S01 Ciribè2024/PMID38927409 is the same six-month ICDAS trial with 106 randomized and 91 completers (mousse 52/control 39), with original attrition of 14.2%. Existing white-spot scores are distinguished from new caries, filling treatment and patient daily-life outcomes. The same report, people, teeth, lesions, groups, repeated time points and parent/sibling questions are not added as new independent trials/participants. Unique clinical totals are not recorded; record slots are not independent totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored summary	Stored file	Stored summary	Summary read	Only the stored JSON summary and bibliography were used for production. This does not constitute external verification or completed content review.
External paper	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Registration material	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Protocol	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Statistical analysis plan	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.
Funding, product-support and COI material	Public availability unverified; only bibliography links preserved	Unread; access not attempted	Not read	No external access or click testing was performed in the original preparation. URLs or registration identifiers alone do not upgrade acquisition/reading status.

Report counts versus independent study counts

S01 Ciribè2024/PMID38927409 is the same six-month ICDAS trial with 106 randomized and 91 completers (mousse 52/control 39), with original attrition of 14.2%. Existing white-spot scores are distinguished from new caries, filling treatment and patient daily-life outcomes. The same report, people, teeth, lesions, groups, repeated time points and parent/sibling questions are not added as new independent trials/participants. Unique clinical totals are not recorded; record slots are not independent totals.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which existing values are recorded for the caries-prevention question?

Required materials and conditions: Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes
Conditions for verification: Relevant source material and analysis scope for "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

N02 · Was incident caries actually measured?

Required materials and conditions: Distinguish incident caries/new clinical events from existing lesion scores
Conditions for verification: Relevant source material and analysis scope for "Distinguish incident caries/new clinical events from existing lesion scores" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Distinguish incident caries/new clinical events from existing lesion scores" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

N03 · Is existing white-spot ICDAS change the same as prevention of new caries?

Required materials and conditions: Existing lesions/visible remineralization, ICDAS and new events
Conditions for verification: Relevant source material and analysis scope for "Existing lesions/visible remineralization, ICDAS and new events" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Existing lesions/visible remineralization, ICDAS and new events" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

N04 · What outcome scope do ICDAS change values and P describe?

Required materials and conditions: Original 0.80/0.39 points, P=.003 and lower-is-better direction
Conditions for verification: Relevant source material and analysis scope for "Original 0.80/0.39 points, P=.003 and lower-is-better direction" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original 0.80/0.39 points, P=.003 and lower-is-better direction" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design

N05 · How are baseline/six-month scores and the original change difference retained?

Required materials and conditions: Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference
Conditions for verification: Relevant source material and analysis scope for "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application

N06 · Does a clinically important minimum difference mean caries prevention?

Required materials and conditions: Distinguish lesion-score importance, direct clinical events and between-group intervals
Conditions for verification: Relevant source material and analysis scope for "Distinguish lesion-score importance, direct clinical events and between-group intervals" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Distinguish lesion-score importance, direct clinical events and between-group intervals" to link materials needed for the selected question with the currently available material.
Referenced methods: M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4; Chamgap's own limits on extension

N07 · Were filling treatment, pain or oral daily-life outcomes reported?

Required materials and conditions: Filling treatment/oral function, appearance assessment and new clinical outcomes
Conditions for verification: Relevant source material and analysis scope for "Filling treatment/oral function, appearance assessment and new clinical outcomes" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Filling treatment/oral function, appearance assessment and new clinical outcomes" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

N08 · Which patients after orthodontic treatment were included?

Required materials and conditions: Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope
Conditions for verification: Relevant source material and analysis scope for "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.1; detailed population conditions are Chamgap's own design

N09 · Are the original F-ACP components the same as other product families?

Required materials and conditions: Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products
Conditions for verification: Relevant source material and analysis scope for "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design

N10 · What historical research conditions did the Essix retainer and six-month exposure describe?

Required materials and conditions: Original mousse in a retainer, actual exposure/adherence and control
Conditions for verification: Relevant source material and analysis scope for "Original mousse in a retainer, actual exposure/adherence and control" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original mousse in a retainer, actual exposure/adherence and control" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

N11 · What did the control group receive?

Required materials and conditions: Mousse-control composition/appliance, common care and placebo definition
Conditions for verification: Relevant source material and analysis scope for "Mousse-control composition/appliance, common care and placebo definition" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Mousse-control composition/appliance, common care and placebo definition" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

N12 · What is known about allocation and assessor blinding in the randomized design?

Required materials and conditions: Allocation-sequence generation/concealment and measurement of ICDAS/caries events
Conditions for verification: Relevant source material and analysis scope for "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 §8.1–8.2.3; internal application; M08 Table 8.2.a, M03 §3.2.4; internal application

N13 · What are the denominators of 106 randomized, 91 completers and 52/39?

Required materials and conditions: Distinguish randomized/completer populations, group denominators and original 14.2% attrition
Conditions for verification: Relevant source material and analysis scope for "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

N14 · Can completer analysis describe effects in everyone randomized?

Required materials and conditions: Scope of original completers, ITT/missing-data plans and baseline/within-group selection
Conditions for verification: Relevant source material and analysis scope for "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

N15 · Are people, teeth, lesions and repeated measurements the same units?

Required materials and conditions: Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations
Conditions for verification: Relevant source material and analysis scope for "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

N16 · What are the actual observation windows for six-month ICDAS and caries incidence?

Required materials and conditions: Original six-month surrogate outcome and clinical-event periods/follow-up
Conditions for verification: Relevant source material and analysis scope for "Original six-month surrogate outcome and clinical-event periods/follow-up" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original six-month surrogate outcome and clinical-event periods/follow-up" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed

N17 · What prespecified endpoint hierarchy included ICDAS and caries events?

Required materials and conditions: Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity
Conditions for verification: Relevant source material and analysis scope for "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" to link materials needed for the selected question with the currently available material.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; Chamgap's own application

N18 · Are the same report, sibling remineralization question and population kept separate from independent totals?

Required materials and conditions: Ciribè2024, 106/91 participants and shared lesion/caries questions
Conditions for verification: Relevant source material and analysis scope for "Ciribè2024, 106/91 participants and shared lesion/caries questions" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Ciribè2024, 106/91 participants and shared lesion/caries questions" to link materials needed for the selected question with the currently available material.
Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application

N19 · Are no external funding and unverified product provision/COI the same?

Required materials and conditions: Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles
Conditions for verification: Relevant source material and analysis scope for "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" to link materials needed for the selected question with the currently available material.
Referenced methods: Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design

N20 · Does 'registration not identified' verify actual absence?

Required materials and conditions: Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP
Conditions for verification: Relevant source material and analysis scope for "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" to link materials needed for the selected question with the currently available material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M08 Table 8.2.a, M04 §4.6.3; internal application

N21 · What collection scope underlies six-month non-reporting of adverse effects?

Required materials and conditions: Patient/caregiver reports, denominators/time and distinction from zero risk
Conditions for verification: Relevant source material and analysis scope for "Patient/caregiver reports, denominators/time and distinction from zero risk" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Supplementary
Application exceptions: Address gaps in harm material for the selected new-caries-prevention question. Do not use ICDAS, original non-reporting of adverse effects or the Good wording to judge overall safety or generate harm rates or guidance on product choice, use or suitability.
Why this condition is needed: This production item distinguishes "Patient/caregiver reports, denominators/time and distinction from zero risk" to link materials needed for the selected question with the currently available material.
Referenced methods: M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap's own design; M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap's own application; M19 §19.1.2–19.2.4; Chamgap's own application; Chamgap's own interpretive boundary. M19 principles are referenced; no official causality tool was run

N22 · Do sales/recommendation or other-product/population statements establish caries prevention?

Required materials and conditions: Original distribution history, this F-ACP surrogate outcome and direct material outside the scope
Conditions for verification: Relevant source material and analysis scope for "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4: principles for clarifying the question; detailed separation rules are Chamgap's own design; M03 §3.2.1; detailed population conditions are Chamgap's own design; M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap's own design

N23 · What was actually read from the stored summary, external papers and linked material?

Required materials and conditions: Stored summary, PMID38927409 URL and unread registration/plans/COI
Conditions for verification: Relevant source material and analysis scope for "Stored summary, PMID38927409 URL and unread registration/plans/COI" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Stored summary, PMID38927409 URL and unread registration/plans/COI" to link materials needed for the selected question with the currently available material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

N24 · How are existing Korean/English texts, grade ?/C50, dates, corrections and empty values retained?

Required materials and conditions: Selected grade ?/note, parent C50/Good, null/false and 2026-08-26
Conditions for verification: Relevant source material and analysis scope for "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" to link materials needed for the selected question with the currently available material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

N25 · How are condition preservation, case production and content review distinguished?

Required materials and conditions: Condition preservation, freezing, application, case production and incomplete content review
Conditions for verification: Relevant source material and analysis scope for "Condition preservation, freezing, application, case production and incomplete content review" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Requirement and applicability: Required
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Why this condition is needed: This production item distinguishes "Condition preservation, freezing, application, case production and incomplete content review" to link materials needed for the selected question with the currently available material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Preserved method HTML copies; no current method-content re-review or official tool execution

What the statuses mean

Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete.
Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete: User review pending.
Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable: Not used as a substitute for an evidence gap.
Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-10 · Public page/material version 1.0

The public page and data were prepared from the existing 25 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which existing values are recorded for the caries-prevention question?

Current findings: The selected existing question is 'prevention of incident caries', with original grade ? and note 'not measured'. Parent C50, Good and S/R1/I1/E+/B2 are context from the existing white-spot remineralization verdict; subclaim score, status and axes are absent.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. No new caries-prevention grade/effect is created and parent values are not inherited. Review of the existing content remains incomplete.
Reason for missing information: No new caries-prevention grade/effect is created and parent values are not inherited.
Required materials and conditions: Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes"
Further research: Proposed follow-up material linking "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

Related sources S01

N02 · Was incident caries actually measured?

Current findings: The existing note and counterview say reductions in new caries/filling treatment were not measured. This is not changed into 0 events, confirmed prevention or a numerical finding of no effect.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Currently needed information is unverified. Direct caries definitions, events/denominators, observation windows and between-group effects/intervals are absent or unverified. Review of the existing content remains incomplete.
Reason for missing information: Direct caries definitions, events/denominators, observation windows and between-group effects/intervals are absent or unverified.
Required materials and conditions: Distinguish incident caries/new clinical events from existing lesion scores
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Distinguish incident caries/new clinical events from existing lesion scores"
Further research: Proposed follow-up material linking "Distinguish incident caries/new clinical events from existing lesion scores" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Distinguish incident caries/new clinical events from existing lesion scores" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Distinguish incident caries/new clinical events from existing lesion scores" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

Related sources S01

N03 · Is existing white-spot ICDAS change the same as prevention of new caries?

Current findings: The original endpoint is the six-month ICDAS white-spot score, where higher is worse. Decreases in existing lesion scores are not transferred into incident-caries rates, fillings/pain or improved daily functioning.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. New lesion/caries events, individual links to progression/recovery of existing lesions and clinical-event results remain unverified. Review of the existing content remains incomplete.
Reason for missing information: New lesion/caries events, individual links to progression/recovery of existing lesions and clinical-event results remain unverified.
Required materials and conditions: Existing lesions/visible remineralization, ICDAS and new events
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Existing lesions/visible remineralization, ICDAS and new events"
Further research: Proposed follow-up material linking "Existing lesions/visible remineralization, ICDAS and new events" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Existing lesions/visible remineralization, ICDAS and new events" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Existing lesions/visible remineralization, ICDAS and new events" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

Related sources S01

N04 · What outcome scope do ICDAS change values and P describe?

Current findings: The original ICDAS reduction of 0.80 versus 0.39 points, with between-group P=.003, is the original lesion-score result. It is not changed into a caries-prevention rate, independent-living/patient responder proportion or new between-group difference/CI.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Group/lesion denominators, models, exact CIs and prespecified importance remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Group/lesion denominators, models, exact CIs and prespecified importance remain unverified.
Required materials and conditions: Original 0.80/0.39 points, P=.003 and lower-is-better direction
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original 0.80/0.39 points, P=.003 and lower-is-better direction"
Further research: Proposed follow-up material linking "Original 0.80/0.39 points, P=.003 and lower-is-better direction" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original 0.80/0.39 points, P=.003 and lower-is-better direction" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original 0.80/0.39 points, P=.003 and lower-is-better direction" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design

Related sources S01

N05 · How are baseline/six-month scores and the original change difference retained?

Current findings: The existing Korean verdict rationale's mousse 1.80→1.00, control 1.92→1.53 and change difference of 0.41 points are retained. No new reductions/differences are calculated from scores or converted into caries incidence.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Analysis populations, adjustment/rounding, intervals and scale aggregation details for scores/change differences remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Analysis populations, adjustment/rounding, intervals and scale aggregation details for scores/change differences remain unverified.
Required materials and conditions: Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference"
Further research: Proposed follow-up material linking "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application

Related sources S01

N06 · Does a clinically important minimum difference mean caries prevention?

Current findings: Statistical ICDAS change and original parent C50 are historical surrogate-outcome context. Neither 0.41 points nor P is used as a prespecified important difference, new caries-prevention effect or individual target.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Currently needed information is unverified. Prespecified ICDAS importance, between-group CIs and validated links to clinical events remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Prespecified ICDAS importance, between-group CIs and validated links to clinical events remain unverified.
Required materials and conditions: Distinguish lesion-score importance, direct clinical events and between-group intervals
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Distinguish lesion-score importance, direct clinical events and between-group intervals"
Further research: Proposed follow-up material linking "Distinguish lesion-score importance, direct clinical events and between-group intervals" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Distinguish lesion-score importance, direct clinical events and between-group intervals" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Distinguish lesion-score importance, direct clinical events and between-group intervals" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4; Chamgap's own limits on extension

Related sources S01

N07 · Were filling treatment, pain or oral daily-life outcomes reported?

Current findings: The existing counterview records that reduced filling treatment was not measured. Wording that visible remineralization may be useful is not turned into numerical pain, chewing/daily-life improvement or actual treatment reduction.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Currently needed information is unverified. Direct filling/treatment, pain/oral daily-life scales, denominators/periods and between-group values remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Direct filling/treatment, pain/oral daily-life scales, denominators/periods and between-group values remain unverified.
Required materials and conditions: Filling treatment/oral function, appearance assessment and new clinical outcomes
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Filling treatment/oral function, appearance assessment and new clinical outcomes"
Further research: Proposed follow-up material linking "Filling treatment/oral function, appearance assessment and new clinical outcomes" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Filling treatment/oral function, appearance assessment and new clinical outcomes" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Filling treatment/oral function, appearance assessment and new clinical outcomes" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension

Related sources S01

N08 · Which patients after orthodontic treatment were included?

Current findings: The original population has white spots after orthodontic treatment, and the existing English research account describes adolescents. This is not extended to all ages/teeth, general caries prevention or populations with other conditions.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Exact ages, eligibility, orthodontic/baseline lesions, oral risk, comorbidities and recruitment conditions remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Exact ages, eligibility, orthodontic/baseline lesions, oral risk, comorbidities and recruitment conditions remain unverified.
Required materials and conditions: Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope"
Further research: Proposed follow-up material linking "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.1; detailed population conditions are Chamgap's own design

Related sources S01

N09 · Are the original F-ACP components the same as other product families?

Current findings: Original F-ACP is an amorphous calcium-phosphate complex containing fluoride and carbonate. Fluoride/CPP-ACP in the original product-distribution wording is not reused as the same composition or preventive effect as this F-ACP.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Exact concentrations, product identity, lots/manufacturing, formulation equivalence and direct material for other products remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Exact concentrations, product identity, lots/manufacturing, formulation equivalence and direct material for other products remain unverified.
Required materials and conditions: Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products"
Further research: Proposed follow-up material linking "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design

Related sources S01

N10 · What historical research conditions did the Essix retainer and six-month exposure describe?

Current findings: The original trial applied mousse in an Essix retainer for six months. This exposure is not changed into amounts/frequency, implementation/suitability instructions or product recommendations.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Actual amounts/frequency, adherence/crossover, group exposure/concomitant care and control-management details remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Actual amounts/frequency, adherence/crossover, group exposure/concomitant care and control-management details remain unverified.
Required materials and conditions: Original mousse in a retainer, actual exposure/adherence and control
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original mousse in a retainer, actual exposure/adherence and control"
Further research: Proposed follow-up material linking "Original mousse in a retainer, actual exposure/adherence and control" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original mousse in a retainer, actual exposure/adherence and control" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original mousse in a retainer, actual exposure/adherence and control" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

Related sources S01

N11 · What did the control group receive?

Current findings: The original material contains control scores and a randomized controlled design, but absent exact control composition, appliance or oral care is not filled in. No treatment, appliance alone or an equivalent-fluoride control is not assumed.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Currently needed information is unverified. Control formulations, common/group care, fluoride/toothpaste/other exposures and blinding remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Control formulations, common/group care, fluoride/toothpaste/other exposures and blinding remain unverified.
Required materials and conditions: Mousse-control composition/appliance, common care and placebo definition
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Mousse-control composition/appliance, common care and placebo definition"
Further research: Proposed follow-up material linking "Mousse-control composition/appliance, common care and placebo definition" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Mousse-control composition/appliance, common care and placebo definition" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Mousse-control composition/appliance, common care and placebo definition" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application

Related sources S01

N12 · What is known about allocation and assessor blinding in the randomized design?

Current findings: The original is a randomized controlled trial. Its original B2 axis or randomized label is not inherited as verification of allocation concealment, patient/assessor blinding or clinical caries-event adjudication.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Allocation/concealment, assessors, ICDAS measurement/photographs and blinding/awareness details remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Allocation/concealment, assessors, ICDAS measurement/photographs and blinding/awareness details remain unverified.
Required materials and conditions: Allocation-sequence generation/concealment and measurement of ICDAS/caries events
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Allocation-sequence generation/concealment and measurement of ICDAS/caries events"
Further research: Proposed follow-up material linking "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Allocation-sequence generation/concealment and measurement of ICDAS/caries events" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 §8.1–8.2.3; internal application; M08 Table 8.2.a, M03 §3.2.4; internal application

Related sources S01

N13 · What are the denominators of 106 randomized, 91 completers and 52/39?

Current findings: 106 randomized, 91 completers (mousse 52/control 39) and original attrition of 14.2% are retained. No new dropout counts/rates, caries-observed participants per group or event denominators are calculated.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Group follow-up, exclusions, dropout reasons, unmeasured clinical events and missing-data responses remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Group follow-up, exclusions, dropout reasons, unmeasured clinical events and missing-data responses remain unverified.
Required materials and conditions: Distinguish randomized/completer populations, group denominators and original 14.2% attrition
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Distinguish randomized/completer populations, group denominators and original 14.2% attrition"
Further research: Proposed follow-up material linking "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Distinguish randomized/completer populations, group denominators and original 14.2% attrition" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

Related sources S01

N14 · Can completer analysis describe effects in everyone randomized?

Current findings: The original account describes 91/106 completer analysis as a limitation. Completer ICDAS values are not extended to caries-prevention effects in all 106 participants, no missing data or complete follow-up.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. ITT/missing-data handling, sensitivity analyses, discontinuers' outcomes and prespecified plans remain unverified. Review of the existing content remains incomplete.
Reason for missing information: ITT/missing-data handling, sensitivity analyses, discontinuers' outcomes and prespecified plans remain unverified.
Required materials and conditions: Scope of original completers, ITT/missing-data plans and baseline/within-group selection
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Scope of original completers, ITT/missing-data plans and baseline/within-group selection"
Further research: Proposed follow-up material linking "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Scope of original completers, ITT/missing-data plans and baseline/within-group selection" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

Related sources S01

N15 · Are people, teeth, lesions and repeated measurements the same units?

Current findings: Original 106/91 and 52/39 are person denominators. How ICDAS was aggregated by tooth/lesion is unknown; each tooth/time point is not counted as a new participant/independent trial.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Lesion/tooth counts, within-person correlation, measurement/analysis models and group/time-point denominators remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Lesion/tooth counts, within-person correlation, measurement/analysis models and group/time-point denominators remain unverified.
Required materials and conditions: Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations"
Further research: Proposed follow-up material linking "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application

Related sources S01

N16 · What are the actual observation windows for six-month ICDAS and caries incidence?

Current findings: The original trial period/ICDAS assessment is six months. It is not labeled as 0 caries events or prevention during that period, persistence afterward or confirmed long-term prevention.
Verification status: Unverified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Currently needed information is unverified. Caries observation/adjudication windows, long-term follow-up, events/missing data and periods after exposure ends remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Caries observation/adjudication windows, long-term follow-up, events/missing data and periods after exposure ends remain unverified.
Required materials and conditions: Original six-month surrogate outcome and clinical-event periods/follow-up
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original six-month surrogate outcome and clinical-event periods/follow-up"
Further research: Proposed follow-up material linking "Original six-month surrogate outcome and clinical-event periods/follow-up" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original six-month surrogate outcome and clinical-event periods/follow-up" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original six-month surrogate outcome and clinical-event periods/follow-up" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed

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N17 · What prespecified endpoint hierarchy included ICDAS and caries events?

Current findings: The existing evidence-list endpoint is six-month ICDAS. Unmeasured caries events are not turned into a primary time point, confirmatory endpoint, prespecified comparison or responder analysis.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Protocols/SAPs, score/clinical-event plans, multiplicity and prespecified importance remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Protocols/SAPs, score/clinical-event plans, multiplicity and prespecified importance remain unverified.
Required materials and conditions: Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity"
Further research: Proposed follow-up material linking "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M08 Table 8.2.a, M04 §4.6.3; Chamgap's own application

Related sources S01

N18 · Are the same report, sibling remineralization question and population kept separate from independent totals?

Current findings: The parent/sibling ICDAS question and this caries-prevention question share the same Ciribè2024 report/population. Teeth/lesions, time points, scores/safety and the two questions are not added as new independent trials or total participants.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Unique clinical trial/participant and independent-replication totals have not been verified and are not recorded. Review of the existing content remains incomplete.
Reason for missing information: Unique clinical trial/participant and independent-replication totals have not been verified and are not recorded.
Required materials and conditions: Ciribè2024, 106/91 participants and shared lesion/caries questions
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Ciribè2024, 106/91 participants and shared lesion/caries questions"
Further research: Proposed follow-up material linking "Ciribè2024, 106/91 participants and shared lesion/caries questions" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Ciribè2024, 106/91 participants and shared lesion/caries questions" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Ciribè2024, 106/91 participants and shared lesion/caries questions" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application

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N19 · Are no external funding and unverified product provision/COI the same?

Current findings: The original funding account says no external funding was received and product-provision wording was not identified in publicly checked COI/acknowledgment text. External full text was not read in this work; this is not changed into no free product support or no company, employee or COI involvement.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Institutional funding, products/manufacturers, employee authors, research/writing contributions, COI and supply agreements remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Institutional funding, products/manufacturers, employee authors, research/writing contributions, COI and supply agreements remain unverified.
Required materials and conditions: Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles"
Further research: Proposed follow-up material linking "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design

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N20 · Does 'registration not identified' verify actual absence?

Current findings: The original registration-identifier record says 'not identified'; the actual identifier remains unrecorded. This is not changed into a confirmed number, absence of registration or absence of a prespecified caries plan.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Registration texts/changes, protocols/SAPs and endpoint/missing-data plans have not been read or accessed. Review of the existing content remains incomplete.
Reason for missing information: Registration texts/changes, protocols/SAPs and endpoint/missing-data plans have not been read or accessed.
Required materials and conditions: Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP"
Further research: Proposed follow-up material linking "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M08 Table 8.2.a, M04 §4.6.3; internal application

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N21 · What collection scope underlies six-month non-reporting of adverse effects?

Current findings: The original safety wording says no adverse effects were reported by patients or caregivers over six months. The original Good label is not extended to overall zero risk, all patients, other products, long-term safety or use recommendations.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Collection/questions, safety denominators, discontinuers/exposure, verification, severity/CIs and long-term/vulnerable-group harms remain unverified. Review of the existing content remains incomplete.
Reason for missing information: Collection/questions, safety denominators, discontinuers/exposure, verification, severity/CIs and long-term/vulnerable-group harms remain unverified.
Required materials and conditions: Patient/caregiver reports, denominators/time and distinction from zero risk
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Patient/caregiver reports, denominators/time and distinction from zero risk"
Further research: Proposed follow-up material linking "Patient/caregiver reports, denominators/time and distinction from zero risk" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Patient/caregiver reports, denominators/time and distinction from zero risk" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Patient/caregiver reports, denominators/time and distinction from zero risk" to link materials needed for the selected question with the currently available material.
Application exceptions: Address gaps in harm material for the selected new-caries-prevention question. Do not use ICDAS, original non-reporting of adverse effects or the Good wording to judge overall safety or generate harm rates or guidance on product choice, use or suitability.
Referenced methods: M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap's own design; M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap's own application; M19 §19.1.2–19.2.4; Chamgap's own application; Chamgap's own interpretive boundary. M19 principles are referenced; no official causality tool was run

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N22 · Do sales/recommendation or other-product/population statements establish caries prevention?

Current findings: The original domestic distribution/recommendation wording is retained in the complete existing review summary. No new verification of current sales/recommendations, effects of all CPP-ACP/fluoride products or guidance on product selection, use, suitability, prevention or treatment is written.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. New verification of other compositions/populations, long-term caries/daily-life clinical outcomes and current distribution is outside scope or unverified. Review of the existing content remains incomplete.
Reason for missing information: New verification of other compositions/populations, long-term caries/daily-life clinical outcomes and current distribution is outside scope or unverified.
Required materials and conditions: Original distribution history, this F-ACP surrogate outcome and direct material outside the scope
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope"
Further research: Proposed follow-up material linking "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4: principles for clarifying the question; detailed separation rules are Chamgap's own design; M03 §3.2.1; detailed population conditions are Chamgap's own design; M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap's own design

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N23 · What was actually read from the stored summary, external papers and linked material?

Current findings: The complete stored summary was read for production and labeled 'summary read', with the original URL retained. External papers, registration, plans and COI material remain 'not read'; past review descriptions/bibliography alone do not raise the reading status in this work.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. External access, abstracts/full text, source comparison and external link/click tests were not performed. Review of the existing content remains incomplete.
Reason for missing information: External access, abstracts/full text, source comparison and external link/click tests were not performed.
Required materials and conditions: Stored summary, PMID38927409 URL and unread registration/plans/COI
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Stored summary, PMID38927409 URL and unread registration/plans/COI"
Further research: Proposed follow-up material linking "Stored summary, PMID38927409 URL and unread registration/plans/COI" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Stored summary, PMID38927409 URL and unread registration/plans/COI" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Stored summary, PMID38927409 URL and unread registration/plans/COI" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

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N24 · How are existing Korean/English texts, grade ?/C50, dates, corrections and empty values retained?

Current findings: The complete review summary's Korean/English texts, parent C50/Good, unrecorded precision/false, empty corrections/deliberation and 2026-08-26 are retained. Selected grade ?/note and absent score/status/axes are distinguished from original limitation checks/cross-check history.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. No source/translation review, new verdict/correction or external update was performed in this existing record. Review of the existing content remains incomplete.
Reason for missing information: No source/translation review, new verdict/correction or external update was performed in this existing record.
Required materials and conditions: Selected grade ?/note, parent C50/Good, null/false and 2026-08-26
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26"
Further research: Proposed follow-up material linking "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

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N25 · How are condition preservation, case production and content review distinguished?

Current findings: Condition preservation, freezing, application, case production and content review are separate records. Review of the existing content is incomplete; record counts are not totals of unique clinical trials/participants.
Verification status: Partly verified
Materials actually read: Summary read; external material unread
Why unverified: Record from the stored summary. Some information is in the stored summary. Review of the existing content is incomplete and clinical source material was not newly verified. Review of the existing content remains incomplete.
Reason for missing information: Review of the existing content is incomplete and clinical source material was not newly verified.
Required materials and conditions: Condition preservation, freezing, application, case production and incomplete content review
Materials to obtain first: Original definitions, result tables/plans or user-provided copies for "Condition preservation, freezing, application, case production and incomplete content review"
Further research: Proposed follow-up material linking "Condition preservation, freezing, application, case production and incomplete content review" as a separate item; no new investigation, calculation or trial is performed in this work.
Remaining uncertainty: This presentation links stored wording. It does not constitute external full-text comparison, an efficacy judgment or completed QA.
Conditions for verification: Relevant source material and analysis scope for "Condition preservation, freezing, application, case production and incomplete content review" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.
Why this condition is needed: This production item distinguishes "Condition preservation, freezing, application, case production and incomplete content review" to link materials needed for the selected question with the currently available material.
Application exceptions: Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.
Referenced methods: M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design

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