{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "F-ACP dental mousse × Prevention of incident caries evidence sheet",
  "language": "en",
  "translation_date": "2026-10-10",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Preserved method HTML copies; no current method-content re-review or official tool execution"
    }
  ],
  "status_dictionary": {
    "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "User review pending.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Which existing values are recorded for the caries-prevention question?",
      "needed": "Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Distinguish subclaim grade ?, note and missing score/status/axes from parent C50/axes\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N02",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Was incident caries actually measured?",
      "needed": "Distinguish incident caries/new clinical events from existing lesion scores",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Distinguish incident caries/new clinical events from existing lesion scores\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Distinguish incident caries/new clinical events from existing lesion scores\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Distinguish incident caries/new clinical events from existing lesion scores\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N03",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Is existing white-spot ICDAS change the same as prevention of new caries?",
      "needed": "Existing lesions/visible remineralization, ICDAS and new events",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Existing lesions/visible remineralization, ICDAS and new events\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Existing lesions/visible remineralization, ICDAS and new events\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Existing lesions/visible remineralization, ICDAS and new events\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N04",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What outcome scope do ICDAS change values and P describe?",
      "needed": "Original 0.80/0.39 points, P=.003 and lower-is-better direction",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original 0.80/0.39 points, P=.003 and lower-is-better direction\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original 0.80/0.39 points, P=.003 and lower-is-better direction\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original 0.80/0.39 points, P=.003 and lower-is-better direction\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N05",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "How are baseline/six-month scores and the original change difference retained?",
      "needed": "Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M08 §8.2.2, M15 §15.3.1; Chamgap's own application; M15 §15.3.1–15.3.3; Chamgap's own application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Roles of 1.80→1.00, 1.92→1.53 and the original 0.41 difference\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N06",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Does a clinically important minimum difference mean caries prevention?",
      "needed": "Distinguish lesion-score importance, direct clinical events and between-group intervals",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Distinguish lesion-score importance, direct clinical events and between-group intervals\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Distinguish lesion-score importance, direct clinical events and between-group intervals\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M15 §15.3.1–15.3.3; Chamgap's own application; M03 §3.2.4; Chamgap's own limits on extension",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Distinguish lesion-score importance, direct clinical events and between-group intervals\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N07",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Were filling treatment, pain or oral daily-life outcomes reported?",
      "needed": "Filling treatment/oral function, appearance assessment and new clinical outcomes",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Filling treatment/oral function, appearance assessment and new clinical outcomes\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Filling treatment/oral function, appearance assessment and new clinical outcomes\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are Chamgap's own design; M03 §3.2.4; Chamgap's own limits on extension",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Filling treatment/oral function, appearance assessment and new clinical outcomes\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N08",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Which patients after orthodontic treatment were included?",
      "needed": "Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.1; detailed population conditions are Chamgap's own design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Post-orthodontic white spots, original English adolescent description and eligibility/baseline scope\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N09",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Are the original F-ACP components the same as other product families?",
      "needed": "Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Fluoride/carbonate-containing amorphous calcium phosphate and boundaries with CPP-ACP/fluoride products\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N10",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What historical research conditions did the Essix retainer and six-month exposure describe?",
      "needed": "Original mousse in a retainer, actual exposure/adherence and control",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original mousse in a retainer, actual exposure/adherence and control\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original mousse in a retainer, actual exposure/adherence and control\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original mousse in a retainer, actual exposure/adherence and control\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N11",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What did the control group receive?",
      "needed": "Mousse-control composition/appliance, common care and placebo definition",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Mousse-control composition/appliance, common care and placebo definition\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Mousse-control composition/appliance, common care and placebo definition\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.2–3.2.3; Reverse-direction labels and assessment adaptation are Chamgap design; M03 §3.2.3 and M08 §8.2.2–8.2.3; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Mousse-control composition/appliance, common care and placebo definition\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N12",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What is known about allocation and assessor blinding in the randomized design?",
      "needed": "Allocation-sequence generation/concealment and measurement of ICDAS/caries events",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Allocation-sequence generation/concealment and measurement of ICDAS/caries events\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Allocation-sequence generation/concealment and measurement of ICDAS/caries events\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 §8.1–8.2.3; internal application; M08 Table 8.2.a, M03 §3.2.4; internal application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Allocation-sequence generation/concealment and measurement of ICDAS/caries events\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N13",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What are the denominators of 106 randomized, 91 completers and 52/39?",
      "needed": "Distinguish randomized/completer populations, group denominators and original 14.2% attrition",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Distinguish randomized/completer populations, group denominators and original 14.2% attrition\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Distinguish randomized/completer populations, group denominators and original 14.2% attrition\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Distinguish randomized/completer populations, group denominators and original 14.2% attrition\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N14",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Can completer analysis describe effects in everyone randomized?",
      "needed": "Scope of original completers, ITT/missing-data plans and baseline/within-group selection",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Scope of original completers, ITT/missing-data plans and baseline/within-group selection\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Scope of original completers, ITT/missing-data plans and baseline/within-group selection\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Scope of original completers, ITT/missing-data plans and baseline/within-group selection\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N15",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Are people, teeth, lesions and repeated measurements the same units?",
      "needed": "Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M15 §15.3 and M19 §19.1.2–19.2.4; Design-specific adaptation is Chamgap design; M08 §8.2.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Distinguish patient denominators, ICDAS aggregation/lesions and repeated-measure correlations\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N16",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What are the actual observation windows for six-month ICDAS and caries incidence?",
      "needed": "Original six-month surrogate outcome and clinical-event periods/follow-up",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original six-month surrogate outcome and clinical-event periods/follow-up\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original six-month surrogate outcome and clinical-event periods/follow-up\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are internally designed",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original six-month surrogate outcome and clinical-event periods/follow-up\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N17",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What prespecified endpoint hierarchy included ICDAS and caries events?",
      "needed": "Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M08 Table 8.2.a, M04 §4.6.3; Chamgap's own application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original lesion-score endpoint, unmeasured caries and prespecified plans/multiplicity\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N18",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Are the same report, sibling remineralization question and population kept separate from independent totals?",
      "needed": "Ciribè2024, 106/91 participants and shared lesion/caries questions",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Ciribè2024, 106/91 participants and shared lesion/caries questions\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Ciribè2024, 106/91 participants and shared lesion/caries questions\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "Study/report distinction in M04 §4.6.1–4.6.2; Cohort/outcome linkage is Chamgap application; M04 §4.6.1–4.6.2 and M15 §15.3.1; Chamgap application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Ciribè2024, 106/91 participants and shared lesion/caries questions\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N19",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Are no external funding and unverified product provision/COI the same?",
      "needed": "Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "Chamgap independence/attribution conditions. The referenced official method sections do not certify every detail of these items; Data collection/selection principles in M04 §4.5–4.6; Access/reading separation and hyperlink rules are Chamgap design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original no-external-funding statement, unidentified products in the publicly checked scope and actual roles\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N20",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Does 'registration not identified' verify actual absence?",
      "needed": "Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design; M08 Table 8.2.a, M04 §4.6.3; internal application",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original registration-identifier record, unrecorded identifier and unread registration/protocol/SAP\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N21",
      "question_type": "Harm-information gaps supplementing the efficacy table",
      "question": "What collection scope underlies six-month non-reporting of adverse effects?",
      "needed": "Patient/caregiver reports, denominators/time and distinction from zero risk",
      "role": "Supplementary",
      "role_reason": "This production item distinguishes \"Patient/caregiver reports, denominators/time and distinction from zero risk\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Address gaps in harm material for the selected new-caries-prevention question. Do not use ICDAS, original non-reporting of adverse effects or the Good wording to judge overall safety or generate harm rates or guidance on product choice, use or suitability.",
      "criterion": "Relevant source material and analysis scope for \"Patient/caregiver reports, denominators/time and distinction from zero risk\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4; detailed distinctions are Chamgap's own design; M19 §19.1.2–19.2.4; Chamgap's own application; M19 §19.1.2–19.2.4, M04 §4.6.3; Chamgap's own application; M19 §19.1.2–19.2.4; Chamgap's own application; Chamgap's own interpretive boundary. M19 principles are referenced; no official causality tool was run",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Patient/caregiver reports, denominators/time and distinction from zero risk\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N22",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "Do sales/recommendation or other-product/population statements establish caries prevention?",
      "needed": "Original distribution history, this F-ACP surrogate outcome and direct material outside the scope",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Original distribution history, this F-ACP surrogate outcome and direct material outside the scope\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Original distribution history, this F-ACP surrogate outcome and direct material outside the scope\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4: principles for clarifying the question; detailed separation rules are Chamgap's own design; M03 §3.2.1; detailed population conditions are Chamgap's own design; M03 §3.2.2–3.2.3; reverse labeling and test adaptations are Chamgap's own design; M03 §3.2.1–3.2.4; dose, duration and effect-modification details are Chamgap's own design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Original distribution history, this F-ACP surrogate outcome and direct material outside the scope\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N23",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "What was actually read from the stored summary, external papers and linked material?",
      "needed": "Stored summary, PMID38927409 URL and unread registration/plans/COI",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Stored summary, PMID38927409 URL and unread registration/plans/COI\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Stored summary, PMID38927409 URL and unread registration/plans/COI\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Stored summary, PMID38927409 URL and unread registration/plans/COI\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N24",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "How are existing Korean/English texts, grade ?/C50, dates, corrections and empty values retained?",
      "needed": "Selected grade ?/note, parent C50/Good, null/false and 2026-08-26",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Selected grade ?/note, parent C50/Good, null/false and 2026-08-26\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Selected grade ?/note, parent C50/Good, null/false and 2026-08-26\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M03 §3.1, §3.2.1–3.2.4 question-clarification principles; detailed separation rules are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Selected grade ?/note, parent C50/Good, null/false and 2026-08-26\" as a separate item; no new investigation, calculation or trial is performed in this work."
    },
    {
      "item_id": "N25",
      "question_type": "Efficacy comparison and presentation of stored material",
      "question": "How are condition preservation, case production and content review distinguished?",
      "needed": "Condition preservation, freezing, application, case production and incomplete content review",
      "role": "Required",
      "role_reason": "This production item distinguishes \"Condition preservation, freezing, application, case production and incomplete content review\" to link materials needed for the selected question with the currently available material.",
      "application_exception": "Limited to the stored summary for the selected formulation, population, endpoint and period. It does not substitute for numbers from other formulations/trials/endpoints or unread external material.",
      "criterion": "Relevant source material and analysis scope for \"Condition preservation, freezing, application, case production and incomplete content review\" must be available so that unverified matters can be distinguished. This work links wording from the stored summary; review of the existing content remains incomplete.",
      "basis": "M04 §4.5–4.6 material collection/selection principles; acquisition/reading separation and hyperlink specifications are internally designed; M04 §4.5, §4.6.3; limits of this material conversion follow the review scope and internal design",
      "condition_origin": "Conditions for presenting the stored article as a table; user review is pending. No official assessment tool or QA was run",
      "proposed_research": "Proposed follow-up material linking \"Condition preservation, freezing, application, case production and incomplete content review\" as a separate item; no new investigation, calculation or trial is performed in this work."
    }
  ]
}