Steam-distilled garlic oil 4 mg four times daily × Helicobacter pylori eradication

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Met	Full text not readStored summary read	N01 · Evidence conditionWhich formulation, population and eradication question are being reviewed?Required	This is an uncontrolled observation of steam-distilled garlic-oil monotherapy at 4 mg, 4 times daily for 14 days in adults with H. pylori-positive dyspepsia. The endpoint is negative results on both post-treatment UBT assessments; quantitative UBT with raw garlic and combination antibiotic regimens are excluded context. S1 S2	The original claim, claim conditions and selected question are linked. This verifies the question’s identity and formulation/endpoint boundary, rather than eradication efficacy.	Original locations for the claim, formulation, administration, population, eradication definition, comparison and timing	When a different formulation or antibiotic adjunct is considered as a new question, first establish its direct original material and comparison boundaries.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionCan the study families of the two reports and their restatements be distinguished?Required	There are 2 citations and linked summaries for the McNulty2001 oil report, PMID11683929, and Zardast2016 raw-garlic report, PMID27761418/PMC5052411. Evidence summaries, citations and Korean/English/synthesis texts restate each report. S1 S2	The formulations, results and citations of the two retained reports were linked, but original identities for registration, follow-up reports and unique trials were not checked.	Identity links between reports, citations, registration and follow-up reports from the same study	In an authorized update, link registrations, original trials and follow-up reports, and group recitations from the same family.
3	Met	Full text not readStored summary read	N03 · Evidence conditionWhich summaries, citations and external materials were actually read?Required	The retained Korean/English summaries, evidence tables, citations and correction records were actually read. PubMed, DOI and PMCID are gateway clues; external abstracts/full texts, appendices and registrations remain unread, with access not attempted. S1 S2	Exact locations, original typed values and identity of local reading were separated from unread external materials for each material.	Acquisition, actual reading, original locations, dates, hashes and original-material gateways for each material	If full texts or appendices are read in a separately authorized update, add actual sections, dates and original identities.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWhich H. pylori-positive adult population do the 5 completers represent?Required	S1 concerns 5 adult completers with H. pylori-positive dyspepsia. S2 reports 15 people with raw garlic; they are not combined as S1’s recruited population or the same completers. S1 S2	Disease, adulthood, dyspepsia and the completer scope are retained. Original data on diagnostic details, eligibility and representativeness remain insufficient.	Diagnosis, dyspepsia, age, eligibility, baseline status and recruitment route	Application to another population requires direct research with that population, the same formulation and an eradication endpoint.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionAre the ingredients and product identity of steam-distilled garlic-oil capsules established?Required	S1 uses steam-distilled garlic-oil capsules made from Allium sativum L. clove essential oil; sulfur-compound specifications are unverified. Raw garlic, powder, AGE and allicin are not interchangeable. S1	Raw material, formulation and route are stated, but actual sulfur-compound specifications and batch/manufacturing/content records were not verified.	Raw material, steam-distillation process, sulfur-compound specifications, manufacturing/batch and content testing	Record product specifications and batches in subsequent comparisons and distinguish results from other formulations.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionDo 4 mg, 4 times daily for 14 days establish actual intake and adherence?Required	The retained prescribed regimen is oil 4 mg, 4 times daily (16 mg/day) for 14 days. S2’s raw garlic 3 g, 2 times daily for 3 days is not used as an equivalent oil dose or direct dose comparison. S1 S2	Prescribed dose, frequency and duration were checked. Material establishing actual intake, adherence, discontinuation and product content is unavailable.	Prescribed dose, actual administered dose, frequency, adherence, discontinuation and product content	An optimal-dose claim separately requires direct dose comparisons with the same specified product and eradication assessment.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow far are concomitant and rescue treatments in the oil-monotherapy observation established?Required	S1 is a garlic-oil monotherapy pilot. The allicin-containing antibiotic 4-drug regimen is described only as a separate combination prescription; there is no evidence/citation report 3. S1 S2	The monotherapy-versus-combination boundary was checked. This does not establish every concomitant treatment, rescue treatment or change in S1.	Antibiotics, acid suppressants, other treatments, intake changes, rescue treatment and adherence records	When comparing causal effects of oil, prospectively record background treatment, changes and rescue treatment.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionIs there a concurrent comparator, and which differences can be compared?Required for between-group efficacy; boundary for single-arm observation	S1 has no concurrent comparator. Eradication 0/5 among completers is an oil-monotherapy observation, rather than a placebo-adjusted difference, between-group RR/CI or antibiotic noninferiority estimate. S1	The lack of a concurrent comparator and the observation’s scope are stated. Comparator data needed to answer between-group efficacy conditions are unavailable.	Actual comparator, background treatment, time points, population and comparison of interest	Causal or replacement claims require an appropriate concurrent comparison with the same formulation and confirmed-eradication endpoint.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionWhen were the two UBT assessments performed after 14 days of treatment?Required	Oil treatment for 14 days and 2 post-treatment UBT assessments are retained. Exact intervals between test visits remain unverified. S1	Treatment duration and the number of tests were checked. The 14-day treatment is not described as the exact follow-up duration through both tests.	Treatment end, the two test visits, intervals, concomitant-treatment withdrawal and follow-up schedule	Subsequent research should separately plan and report treatment end and eradication-confirmation time points.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionAre the two-negative-UBT eradication definition and test thresholds established?Required	The selected eradication endpoint is the proportion negative on both post-treatment UBT assessments. S2’s quantitative UBT change is not an eradication endpoint; eradication rate was not assessed. S1 S2	The rule combining two negative tests and its difference from quantitative change are stated. Test details and negative thresholds were not established.	UBT type, negative threshold, assessment, testing conditions and the rule combining both tests	Subsequent eradication research should state negative-result rules and testing conditions.
11	Met	Full text not readStored summary read	N11 · Evidence conditionWhat was observed in completer eradication 0/5 and no suppression?Required	The retained S1 result is eradication 0/5 with no suppression. The adverse observation that all completers failed is retained and is not replaced by S2’s UBT decrease. S1	The current result, completer denominator and uncontrolled boundary were linked. This preserves a failure observation rather than a precise E0, replicated refutation RX or verdict of ineffectiveness.	Two tests per participant, eradication/suppression results and endpoint-specific analysis tables	Compare additional evidence using the same formulation and confirmed-eradication endpoint while retaining the earlier failure.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionCan the 5 completers be distinguished from original enrollment and analysis denominators?Required	The established S1 denominator is 5 completers; original enrollment remains unverified. S2’s 15 people are not added to create a participant total or common analysis denominator. S1 S2	The original completer denominator and unverified enrollment denominator were separately retained. The complete recruitment-to-analysis flow cannot be established.	Participant counts and flow through recruitment, enrollment, exposure, testing, completion and analysis	Subsequent research should disclose participant flow from recruitment through both tests and analysis.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionAre losses, missed tests, missingness and completer selection established?Required	The retained summary supplies only 5 completers and an unverified original enrollment denominator. Reasons for losses, missed tests or missingness and handling rules were not established. S1	Completer observations exist, but original participant-flow and missing-data material needed to establish this condition is unavailable.	Reasons for losses, missed tests, missingness, completion criteria, analytical handling and original participant flow	Subsequent research should prospectively define missing-data handling and analysis populations, separating them from completer-only results.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionWhat design governs recruitment and selection in the uncontrolled pilot?Required for causal interpretation	S1 is an uncontrolled pilot; the retained text states that randomization and a concurrent comparator were absent. Detailed recruitment, selection and baseline methods are absent from the current summary. S1	The uncontrolled design and causal limitations were checked. Randomization, concealment and baseline balance were not attributed.	Single-arm design, recruitment/selection, baseline status, allocation status and original methods	Research on causal effects should prospectively state an appropriate comparative design and the allocation/selection process.
15	Unverified	Full text not readStored summary read	N15 · Evidence conditionAre standardization and blinding of UBT measurement and assessment established?Required	The retained summary did not establish assessors, blinding, sampling standardization or error management for the two UBT assessments. The name UBT does not verify these procedures. S1	The test name and two-negative definition alone cannot establish measurement standardization or blinding.	Consistent test method, sampling/testing conditions, assessors, blinding and error management	Subsequent research should standardize testing and assessment, recording assessment blinding where it can be established.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhich analysis and effect of interest do completer results answer?Required	0/5 is a single-arm completer eradication observation. The retained text states that between-group RR/CI cannot be calculated and provides no analysis name, ITT/PP or missing-data details. S1	The actual observation population and absence of concurrent comparison were checked. Planned effects of interest and analysis rules could not be compared.	Analysis population, participant event tables, ITT/PP, within-/between-group distinctions and analysis plan	A subsequent comparison should define its effect of interest, analysis population and missing-data handling before results are reported.
17	Unverified	Full text not readStored summary read	N17 · Evidence conditionAre the eradication observation’s precision and important-difference criterion established?Required for effect precision	Retain the original S1 statement that between-group RR/CI cannot be calculated without a concurrent comparator. Single-arm CI, P and important-difference criteria are also absent from the retained summary. S1	Reported event counts alone cannot establish comparative precision, equivalence, confirmatory strength or an important difference, and new calculations are not authorized.	Endpoint-specific events/denominators, originally reported intervals, justified important differences and concurrent comparison	Plan precision for future questions using a justified important difference and an appropriate design; do not invent a minimum n.
18	Unverified	Full text not readStored summary read	N18 · Evidence conditionWere planned endpoints compared with the registration, protocol and actual report?Required	The native registration values for S1 and S2 each state that confirmation was not possible. External registrations, protocols and analysis plans were not read in this conversion. S1 S2	Plan material for comparing prespecified endpoints, time points and denominators with actual reports is unavailable; a current registration lookup was not performed.	Registration ID, protocol, analysis plan, endpoint/time-point changes and results	In a separate update, acquire registration, plans and change histories and review the linked results.
19	Met	Full text not readStored summary read	N19 · Evidence conditionIs the UBT decrease in 15 people receiving raw garlic replication of oil eradication?Required for directness and replication boundaries	S2 reports an uncontrolled before-after quantitative UBT decrease in 15 people receiving raw garlic 3 g, 2 times daily for 3 days; eradication rate was not assessed. Its formulation and endpoint differ from S1’s oil for 14 days, 5 completers and eradication 0/5. S1 S2	The two reports’ retained formulation, duration, denominator and endpoint differences were linked. S2 was not combined as oil-eradication success, refutation or independent replication.	Links between the two reports’ formulations, doses, timing, denominators, endpoints and families	Independently identify replication of the same oil-eradication question using the same formulation, definition and time points.
20	Unverified	Full text not readStored summary read	N20 · Evidence conditionDoes the record answer dose optimization, persistent eradication or other populations?Supplementary; required for the stated extension	The retained two reports did not establish direct dose comparisons for the same oil, persistent eradication after stopping or prespecified subgroup evidence. S1 S2	A single-dose 14-day observation and a 3-day report using another formulation cannot establish optimal dose, long-term persistence or effects in other populations.	Direct dose comparisons using the same formulation, post-discontinuation follow-up and subgroup/interaction evidence	When extension questions are requested, separate them into appropriate dose, follow-up and population designs.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionDo UBT and eradication observations also answer antibiotic replacement and clinical events?Supplementary; required for clinical-event or replacement claims	The retained text states that in-vitro antibacterial activity or decreased UBT values cannot be advertised as successful eradication or antibiotic replacement. The allicin-containing antibiotic 4-drug regimen is boundary narrative about a combination prescription. S1 S2	The selected endpoint and clinical/replacement boundaries were checked. Direct comparative material on antibiotic replacement, ulcers, bleeding, cancer or symptoms is absent from the retained record.	Separate comparisons for eradication versus symptoms, ulcers, bleeding, cancer and treatment replacement	Antibiotic replacement and clinical events require separate questions, appropriate direct comparisons and safety follow-up.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionWhat are the original review/correction dates and the scope of current reading/searching?Required	The original verdict-review date is 2026-09-08 and the retained English correction is dated 2026-09-14. Current reading concerns the 2026-10-06 retained summaries; no new clinical search or comprehensive external registration/retraction/correction lookup was performed. S1 S2	Verdict, correction and current-reading dates were linked. Material establishing the original search cut-off/scope and current external publication status is unavailable.	Review/correction dates, input identities, actual reading and search/registration/retraction checks	In an authorized evidence update, record search scope, dates and unpublished/registration/correction status as a separate event.
23	Unverified	Full text not readStored summary read	N23 · Evidence conditionHow far are funding, product provision and author interests established?Supplementary; required for independence claims	S1 states that funding and product provision are unverified; S2 states academic research with details unverified. English funding wording and the original I1 axis are retained as historical text. S1 S2	Original sections containing individual funding, product-provision and author/institution declarations were not read, so independent funding or absence of interests was not verified.	Original-paper funding, product provision, employment/patents, interest declarations and institutions	In a separate update, check funding, product and author relationships without automatically excluding results or approving them as unbiased.
24	Unverified	Full text not readStored summary read	N24 · Evidence conditionAre the original warning and actually collected adverse events distinguished?Supplementary; required for safety questions	The original warning states that replacing antibiotic-based treatment and eradication confirmation with garlic may delay management of ulcer, bleeding and gastric-cancer risk. Actual adverse-event counts in S1 are absent from the retained summary. S1	The warning was checked, but event definitions, collection, severity and discontinuation for the same oil administration cannot be verified. The warning is not presented as observed events.	Event definitions, collection, severity and discontinuation for the same oil exposure, and the original warning	When studying harms with the same formulation, separately design event definitions, collection and discontinuation procedures from efficacy endpoints.
25	Unverified	Full text not readStored summary read	N25 · Evidence conditionAre harm-exposure, onset/recovery timing and denominators available?Supplementary; required for incidence or causal claims	Oil treatment for 14 days and 5 efficacy completers are retained, but denominators for harms assessment, onset/recovery, exposure/follow-up time and rechallenge data are absent from the retained summary. S1	The efficacy denominator and treatment duration cannot be inherited as data for harm incidence, follow-up or temporal sequence.	Harms-assessed exposed people, affected people/event counts, observation periods, discontinuation/recovery and rechallenge	Collect exposure, events, follow-up and discontinuation information separately when observing harms with the same formulation.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionCan harm comparisons, concurrent treatments and alternative causes be established?Supplementary; required for comparative or causal harms	S1’s uncontrolled design and the treatment-replacement warning are retained. A harms comparator, baseline events, simultaneous exposures and event-specific alternative explanations for the same oil were not established. S1	Without event material, comparisons or alternative causes, increased risk caused by oil or individual causation cannot be attributed.	Harms comparator, baseline events, simultaneous exposures, concurrent treatments, alternative explanations and adjustment	Comparative-harm questions should record an appropriate comparator and event-specific baseline and simultaneous exposures.
27	Unverified	Full text not readStored summary read	N27 · Evidence conditionIs the scope of harm collection, omission, losses and disclosure established?Supplementary; required for safety claims	The two evidence summaries in the retained record lack detailed tables on harm collection, omission, losses or detection differences. External original papers and appendices remain unread. S1 S2	The material could not be established from the summary; collection, disclosure and missingness across the entire original paper were not reviewed.	Collection of all events, spontaneous reporting, detection, nonreporting, follow-up losses and exclusions	In a separate update, link harms tables, discontinuation reasons and collection plans and review the scope of missing information.
28	Unverified	Full text not readStored summary read	N28 · Evidence conditionWhat is the scope of independent harms material, long-term observation and vulnerable populations?Supplementary; required for replication or expanded safety	Independent oil-harm families, long-term/rare events and vulnerable-population material could not be established in the retained summary. Korean/English/synthesis warning restatements and the raw-garlic report are not counted as independent oil-harm events. S1 S2	Without independent identities and appropriate follow-up for the same product/events, replicated or expanded safety cannot be verified.	Unique harms families, product matching, long-term/rare events and vulnerable-population follow-up	Expanded safety questions require separate consideration of appropriate long-term and rare-event/vulnerable-population designs.
29	Met	Full text not readStored summary read	N29 · Evidence conditionDoes the wording distinguish warning, signal, comparative risk and causality?Supplementary; required for safety or causal harms	The current warning is an interpretation boundary concerning potentially delayed management when validated treatment is replaced. No new verdict on direct oil-harm signals, comparative risk, causality or safety grade is created. S1	The level of the original warning was separated from unverified actual harm material. This checks a wording boundary rather than establishing clinical safety.	Events, comparator, denominator, timing, alternative explanations and the level of the original warning for the same exposure	If direct harms material is added, review the level of wording within the same event, population and exposure boundaries.
30	Met	Full text not readStored summary read	N30 · Evidence conditionAre original C46, Warning, all axes, Korean/English text and correction separated from new states?Required	Retain original C46, Warning, B/S/R1/I1/EX/B2/CX and all-axis Boolean/empty-string values, all Korean/English fields, 1 correction, 2 reports/2 citations, empty subclaims and URLs unchanged. S1 S2	The complete identical bytes and original typed content of the current source, retained copy and inputs were linked. Historical verdicts and generic English wording were not inherited as new states, reading or scores.	Whole original summary, original data types, both languages/axes, correction, URLs and empty subclaims	If a correction or update is separately requested, retain the whole original text and distinguish the event, condition version and verdict decision.

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30 itemsWhat the statuses mean

Assessment scope

Stored-material review date: 2026-10-06
Original evidence cut-off: 2026-09-08
Scope actually checked: Retained Korean/English summaries and case-specific condition/application records. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
Population: 5 adult completers with H. pylori-positive dyspepsia. The original enrollment denominator, diagnostic details, eligibility and representativeness remain unverified.
Ingredient, formulation and route: Oral monotherapy with steam-distilled garlic-oil capsules from Allium sativum L. clove essential oil. Sulfur-compound specifications, manufacturing, product/batch identity and actual concurrent treatment remain unverified.
Dose: 4 mg 4 times daily (16 mg/day) is the retained prescribed dose. Actual intake, adherence and discontinuation remain unverified; no dose equivalence with other garlic formulations is inferred.
Comparator: This is a pilot without a concurrent comparator. Completer results are not converted to placebo-adjusted differences, between-group RR, equivalence or noninferiority to antibiotics.
Measured outcome: Proportion negative on both post-treatment urea breath tests (UBT). Test type, negative thresholds, assessment conditions and individual original values remain unverified.
Duration: 14 days of treatment followed by 2 UBT assessments. Exact dates, intervals, concurrent-treatment conditions before testing and long-term persistence remain unverified.
Questions outside this scope: Eradication 0/5 with no suppression is a single-arm completer observation. Original enrollment, exposure, testing and analysis denominators are not filled with 5, and losses or missingness are not filled with 0.; Retain the original statement that between-group RR and CI cannot be calculated. Single-arm CI, P values, proportions, important differences and required sample size are not newly calculated.; The uncontrolled before-after UBT decrease with raw garlic 3 g 2 times daily for 3 days in 15 people is not an eradication rate. It is not merged into success, refutation, direct replication or a dose comparison for garlic-oil eradication.; The allicin-containing 4-drug antibiotic regimen is boundary narrative about a separate combination prescription. It does not create a new report absent from the retained evidence/citations or evidence for antibiotic replacement.; UBT value change, eradication defined by two negative tests, symptoms, ulcers, bleeding, cancer and treatment replacement are distinct questions. Optimal dose, persistence and other populations are not automatically inferred.; The original warning concerns delayed risk management if garlic replaces validated treatment. It is not converted into directly observed adverse events, incidence, causality or individual intake instructions.

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S1 · McNulty CA et al. Helicobacter. 2001;6:249-253. PMID: 11683929. DOI: 10.1046/j.1523-5378.2001.00036.x.

PubMed

Material type: An uncontrolled steam-distilled garlic-oil monotherapy pilot in the retained record. No concurrent comparison or randomization effect is attributed.
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Findings recorded in the stored summary: Eradication 0/5 with no suppression. This is the completer denominator; original enrollment remains unverified, and the retained result states that between-group RR and CI cannot be calculated.
Record level: A single-arm observation in 5 completers receiving 4 mg 4 times daily (16 mg/day) for 14 days. Exact timing and thresholds of the two UBT assessments, analysis plan, losses/missingness and original event tables remain unverified.
Study overlap and independent replication: Separate the two evidence/citation pairs for the uncontrolled oil pilot S1 and raw-garlic before-after report S2. Korean/English/synthesis restatements refer to the same reports. Global unique-trial and participant counts and overlapping/independent families remain unverified. Antibiotic-combination narrative is not counted as an additional report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Retained verdict summary	Retained verdict summary read	Retained copy acquired; summary read	Stored existing review summary read	Relevant content in the retained summary, evidence and citation was read. This is not the original clinical paper’s bytes or full text. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
External PubMed bibliographic/abstract gateway	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	This is the retained PubMed link. The current response, bibliographic identity, abstract content and public access were not checked. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
External DOI full-text gateway	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	A full-text gateway linked from the retained DOI or PMCID. Current public availability, successful access, acquisition and actual reading remain unverified. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
Appendix; identity unverified	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	The appendix’s existence, original location, public availability, download and actual reading were not checked. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
Registration, protocol and analysis plan; identity unverified	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	Retain the original record that registration could not be confirmed. This does not establish absence of registration, selective reporting or an access failure. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.

S2 · Zardast M et al. Avicenna J Phytomed. 2016;6:495-501. PMID: 27761418. PMCID: PMC5052411.

PubMed

Material type: An uncontrolled raw-garlic before-after study in the retained record. It is not a direct comparison of oil monotherapy eradication.
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Findings recorded in the stored summary: Quantitative UBT decreased after raw garlic 3 g 2 times daily for 3 days in 15 people. Eradication rate was not assessed; the exact change, CI and P remain unverified in the retained record.
Record level: A quantitative test change with raw garlic and eradication defined by two negative tests with oil are different endpoints. Participants and results are not combined or counted as direct replication.
Study overlap and independent replication: Separate the two evidence/citation pairs for the uncontrolled oil pilot S1 and raw-garlic before-after report S2. Korean/English/synthesis restatements refer to the same reports. Global unique-trial and participant counts and overlapping/independent families remain unverified. Antibiotic-combination narrative is not counted as an additional report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Retained verdict summary	Retained verdict summary read	Retained copy acquired; summary read	Stored existing review summary read	Relevant content in the retained summary, evidence and citation was read. This is not the original clinical paper’s bytes or full text. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
External PubMed bibliographic/abstract gateway	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	This is the retained PubMed link. The current response, bibliographic identity, abstract content and public access were not checked. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
External PMC full-text gateway	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	A full-text gateway linked from the retained DOI or PMCID. Current public availability, successful access, acquisition and actual reading remain unverified. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
Appendix; identity unverified	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	The appendix’s existence, original location, public availability, download and actual reading were not checked. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.
Registration, protocol and analysis plan; identity unverified	External access not attempted; not acquired; unread	External access not attempted; not acquired	Not read	Retain the original record that registration could not be confirmed. This does not establish absence of registration, selective reporting or an access failure. A report linked to the retained summary and citation. External abstracts, full texts, appendices, registration, protocols and analysis plans remain unread in this conversion; independent clinical validation was not performed. The material check date is the original date retained in the summary and condition records. The original verdict-review date does not establish a search cut-off or historical access dates for individual materials; external access was not attempted in this conversion.

Report counts versus independent study counts

Separate the two evidence/citation pairs for the uncontrolled oil pilot S1 and raw-garlic before-after report S2. Korean/English/synthesis restatements refer to the same reports. Global unique-trial and participant counts and overlapping/independent families remain unverified. Antibiotic-combination narrative is not counted as an additional report.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which formulation, population and eradication question are being reviewed?

Required materials and conditions: Original locations for the claim, formulation, administration, population, eradication definition, comparison and timing
Conditions for verification: Link the original verdict claim and claim conditions to eradication defined by two negative UBT assessments with steam-distilled oil monotherapy, and state the excluded formulations and endpoints.
Requirement and applicability: Required
Application exceptions: Checking the question boundary does not verify efficacy. Raw garlic and combination antibiotic regimens are retained as excluded context.
Why this condition is needed: This prevents garlic as a whole or changes in UBT values from replacing the oil-monotherapy eradication question.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N02 · Can the study families of the two reports and their restatements be distinguished?

Required materials and conditions: Identity links between reports, citations, registration and follow-up reports from the same study
Conditions for verification: Check citation, formulation and endpoint links for the McNulty oil report and Zardast raw-garlic report; verify follow-up reports from the same trial through original study identity.
Requirement and applicability: Required
Application exceptions: The two citations are clues to two reports; global unique-trial and participant counts remain unestablished.
Why this condition is needed: This prevents Korean/English/synthesis texts and evidence/citation restatements from being added as independent replications.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N03 · Which summaries, citations and external materials were actually read?

Required materials and conditions: Acquisition, actual reading, original locations, dates, hashes and original-material gateways for each material
Conditions for verification: Link the actual locations, values and identity of the retained summaries read, and separately record actual access to and reading of external abstracts, full texts, appendices and registrations.
Requirement and applicability: Required
Application exceptions: Access not attempted is not inaccessible. Reading in this conversion is limited to all fields of the retained summary.
Why this condition is needed: This prevents PubMed, DOI or PMCID links and historical verification wording from becoming current full-text reading.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N04 · Which H. pylori-positive adult population do the 5 completers represent?

Required materials and conditions: Diagnosis, dyspepsia, age, eligibility, baseline status and recruitment route
Conditions for verification: Compare the original study’s H. pylori confirmation method, dyspepsia definition, eligibility, baseline characteristics and recruited population with the selected target population.
Requirement and applicability: Required
Application exceptions: Unverified recruitment information does not mean recruitment did not occur. The 15 people receiving raw garlic are not combined into the same sample.
Why this condition is needed: This prevents observations in a very small completer group from being extended to all infected or asymptomatic people.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N05 · Are the ingredients and product identity of steam-distilled garlic-oil capsules established?

Required materials and conditions: Raw material, steam-distillation process, sulfur-compound specifications, manufacturing/batch and content testing
Conditions for verification: Check steam-distilled essential oil, capsules, sulfur-compound specifications and batch/content of the actual administered product against original product records.
Requirement and applicability: Required
Application exceptions: The name garlic oil alone does not establish sulfur-compound specifications or equivalence with other products.
Why this condition is needed: This prevents essential oil from being treated as equivalent to allicin, raw garlic or AGE.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N06 · Do 4 mg, 4 times daily for 14 days establish actual intake and adherence?

Required materials and conditions: Prescribed dose, actual administered dose, frequency, adherence, discontinuation and product content
Conditions for verification: Separately check the oil prescription of 4 mg, 4 times daily for 14 days and actual intake/adherence/discontinuation, without converting doses between formulations.
Requirement and applicability: Required
Application exceptions: 16 mg/day is quoted from the retained record. No new dose calculation or equivalence conversion to grams of raw garlic is made.
Why this condition is needed: This retains the original 16 mg/day while separating prescription from actual intake.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N07 · How far are concomitant and rescue treatments in the oil-monotherapy observation established?

Required materials and conditions: Antibiotics, acid suppressants, other treatments, intake changes, rescue treatment and adherence records
Conditions for verification: Check actual concomitant/rescue treatment, changes and analytical handling during observation, separating them from adjunct effects in an antibiotic 4-drug regimen.
Requirement and applicability: Required
Application exceptions: The retained monotherapy boundary does not establish every concomitant or rescue-treatment detail.
Why this condition is needed: This prevents results from combination antibiotic regimens from being attributed to oil monotherapy.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N08 · Is there a concurrent comparator, and which differences can be compared?

Required materials and conditions: Actual comparator, background treatment, time points, population and comparison of interest
Conditions for verification: Check the existence and content of a concurrent comparator for the eradication result; do not convert a single-arm observation into a between-group difference, RR or noninferiority result.
Requirement and applicability: Required for between-group efficacy; boundary for single-arm observation
Application exceptions: The current uncontrolled observation is retained. Distinguish the absence of a comparator from a future comparative design.
Why this condition is needed: This prevents failure in 0/5 from becoming a placebo-adjusted null effect or noninferiority to antibiotics.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N09 · When were the two UBT assessments performed after 14 days of treatment?

Required materials and conditions: Treatment end, the two test visits, intervals, concomitant-treatment withdrawal and follow-up schedule
Conditions for verification: Link 14 days of treatment to the actual time points, intervals and pretest concomitant-treatment conditions of the two post-treatment UBT visits.
Requirement and applicability: Required
Application exceptions: Do not fill the retained two-test statement with particular dates or confirmed long-term persistence.
Why this condition is needed: This prevents 14 days of treatment from becoming the exact follow-up duration through eradication confirmation.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N10 · Are the two-negative-UBT eradication definition and test thresholds established?

Required materials and conditions: UBT type, negative threshold, assessment, testing conditions and the rule combining both tests
Conditions for verification: Check the original study’s two-negative-post-treatment-UBT definition, test method, thresholds and assessment/conditions, separating them from decreased values.
Requirement and applicability: Required
Application exceptions: Both tests being negative is the selected endpoint. Diagnostic accuracy and symptom improvement are separate questions.
Why this condition is needed: This prevents quantitative UBT decreases or suppression from replacing confirmed eradication.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N11 · What was observed in completer eradication 0/5 and no suppression?

Required materials and conditions: Two tests per participant, eradication/suppression results and endpoint-specific analysis tables
Conditions for verification: Retain the original eradication 0/5 and no-suppression endpoint and completer denominator, distinguishing the single-arm failure observation from a between-group null effect or replicated refutation.
Requirement and applicability: Required
Application exceptions: 0/5 and no suppression are retained observations. Do not create a new proportion, RR, CI, P or replicated refutation.
Why this condition is needed: This prevents an adverse direct observation from being erased by positive raw-garlic values or promoted to a precise null effect.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N12 · Can the 5 completers be distinguished from original enrollment and analysis denominators?

Required materials and conditions: Participant counts and flow through recruitment, enrollment, exposure, testing, completion and analysis
Conditions for verification: Link the completer denominator of 0/5 with original recruitment, exposure, testing and analysis denominators and the original counts at each stage.
Requirement and applicability: Required
Application exceptions: Do not combine participants with the 15 people receiving raw garlic. Unavailable denominators remain null or unverified.
Why this condition is needed: This prevents 5 completers from becoming 5 initially recruited participants or an ITT denominator of 5.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N13 · Are losses, missed tests, missingness and completer selection established?

Required materials and conditions: Reasons for losses, missed tests, missingness, completion criteria, analytical handling and original participant flow
Conditions for verification: Compare discontinuation, missed UBT assessments, reasons for losses and their eradication-analysis handling with original participant flow and the analysis plan.
Requirement and applicability: Required
Application exceptions: The term completer alone does not establish a PP or ITT analysis method.
Why this condition is needed: This prevents an unverified enrollment denominator from becoming 0 losses or an analysis without missing data.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N14 · What design governs recruitment and selection in the uncontrolled pilot?

Required materials and conditions: Single-arm design, recruitment/selection, baseline status, allocation status and original methods
Conditions for verification: Check the actual single-arm recruitment and selection process in the original methods and state causal limitations of observation without randomization or a concurrent comparator.
Requirement and applicability: Required for causal interpretation
Application exceptions: The retained study is uncontrolled; randomization/allocation is not verified. Parallel, crossover or cluster details are not inferred.
Why this condition is needed: This prevents the pilot label from conferring random allocation or baseline balance.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N15 · Are standardization and blinding of UBT measurement and assessment established?

Required materials and conditions: Consistent test method, sampling/testing conditions, assessors, blinding and error management
Conditions for verification: Check testing, sampling and assessment conditions and assessor blinding/error management for both UBT assessments against original procedures.
Requirement and applicability: Required
Application exceptions: UBT use itself does not establish assessor blinding or matching conditions.
Why this condition is needed: This prevents an objective test name from implying that measurement error or assessment bias is resolved.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N16 · Which analysis and effect of interest do completer results answer?

Required materials and conditions: Analysis population, participant event tables, ITT/PP, within-/between-group distinctions and analysis plan
Conditions for verification: Establish that the original 0/5 is a single-arm completer observation and link actual analysis rules and test-specific event tables with the original plan/results.
Requirement and applicability: Required
Application exceptions: No concurrent comparator is available to calculate between-group RR/CI. Do not fill an unverified analysis name.
Why this condition is needed: This prevents single-arm completer results from being transferred to randomized-assignment effects or placebo-adjusted estimates.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N17 · Are the eradication observation’s precision and important-difference criterion established?

Required materials and conditions: Endpoint-specific events/denominators, originally reported intervals, justified important differences and concurrent comparison
Conditions for verification: Compare originally reported eradication estimates, intervals, denominators and grounds for an important difference; do not attribute between-group precision or equivalence to uncontrolled results.
Requirement and applicability: Required for effect precision
Application exceptions: Retain that between-group RR/CI cannot be calculated. Do not newly calculate single-arm CI or P; leave them unverified.
Why this condition is needed: This prevents very small failure observations or significance alone from establishing confirmatory strength, equivalence or required sample size.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N18 · Were planned endpoints compared with the registration, protocol and actual report?

Required materials and conditions: Registration ID, protocol, analysis plan, endpoint/time-point changes and results
Conditions for verification: Compare original registration/plan definitions of eradication, the two tests and analysis populations with actual results by location, distinguishing portions that could not be compared.
Requirement and applicability: Required
Application exceptions: External registration and original plans remain unread in this conversion. The historical original-review date is not a plan-comparison date.
Why this condition is needed: This prevents could not confirm from becoming confirmed nonregistration or selective reporting.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N19 · Is the UBT decrease in 15 people receiving raw garlic replication of oil eradication?

Required materials and conditions: Links between the two reports’ formulations, doses, timing, denominators, endpoints and families
Conditions for verification: Compare S2’s raw garlic 3 g, 2 times daily for 3 days, 15 people and quantitative UBT change/unassessed eradication with S1’s oil, 14 days, 5 completers and eradication, to establish differences in directness.
Requirement and applicability: Required for directness and replication boundaries
Application exceptions: An ancillary report with another formulation and endpoint is retained. It is not classified as conflict within the same question or independent replication.
Why this condition is needed: This prevents a quantitative decrease with raw garlic from being combined as oil-monotherapy eradication success.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N20 · Does the record answer dose optimization, persistent eradication or other populations?

Required materials and conditions: Direct dose comparisons using the same formulation, post-discontinuation follow-up and subgroup/interaction evidence
Conditions for verification: Check direct comparisons/follow-up and prespecified subgroup evidence using the same formulation for optimal-dose, persistent-eradication or other-population claims.
Requirement and applicability: Supplementary; required for the stated extension
Application exceptions: Do not make all long-term and subgroup research mandatory for the narrow 14-day observation.
Why this condition is needed: This prevents a short pilot at one dose from being extended to optimal dose or long-term persistence.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N21 · Do UBT and eradication observations also answer antibiotic replacement and clinical events?

Required materials and conditions: Separate comparisons for eradication versus symptoms, ulcers, bleeding, cancer and treatment replacement
Conditions for verification: Distinguish selected eradication from value changes, symptoms, clinical events and antibiotic replacement; require direct comparative evidence for each extension claim.
Requirement and applicability: Supplementary; required for clinical-event or replacement claims
Application exceptions: Do not require every cancer-prevention trial for the selected eradication endpoint. Do not create a new report solely from the antibiotic 4-drug narrative.
Why this condition is needed: This prevents UBT values or antibacterial mechanisms from being extended to antibiotic replacement or ulcer/cancer prevention.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N22 · What are the original review/correction dates and the scope of current reading/searching?

Required materials and conditions: Review/correction dates, input identities, actual reading and search/registration/retraction checks
Conditions for verification: Separate the 2026-09-08 original review, 09-14 correction record and current reading of retained summaries; accurately state the scope of searches and comprehensive registration/correction/retraction checks.
Requirement and applicability: Required
Application exceptions: The original verdict-review date is neither the current access date nor a search cut-off.
Why this condition is needed: This prevents a retained summary from being described as a current comprehensive literature review or a search returning 0 results.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N23 · How far are funding, product provision and author interests established?

Required materials and conditions: Original-paper funding, product provision, employment/patents, interest declarations and institutions
Conditions for verification: Link each report’s funding, product provision and author/institution declarations to original sections; do not attribute unsupported independence claims.
Requirement and applicability: Supplementary; required for independence claims
Application exceptions: S2’s academic-research wording does not verify independent funding. Unverified interests do not establish absence of involvement.
Why this condition is needed: This prevents historical I1 and generic English wording from being used as proof of independent funding or absence of interests.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N24 · Are the original warning and actually collected adverse events distinguished?

Required materials and conditions: Event definitions, collection, severity and discontinuation for the same oil exposure, and the original warning
Conditions for verification: Check actual adverse-event definitions, systematic/spontaneous collection, severity and discontinuation for oil exposure, separating them from the original treatment-replacement warning.
Requirement and applicability: Supplementary; required for safety questions
Application exceptions: The original warning is retained. Absence of adverse-event counts in an efficacy summary does not mean no events.
Why this condition is needed: This prevents a warning about delayed management after replacing treatment from becoming bleeding or cancer events observed in the pilot.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N25 · Are harm-exposure, onset/recovery timing and denominators available?

Required materials and conditions: Harms-assessed exposed people, affected people/event counts, observation periods, discontinuation/recovery and rechallenge
Conditions for verification: Link harm-exposure/event/recovery times with assessment denominators and follow-up in the same event material before interpreting frequency or temporal sequence.
Requirement and applicability: Supplementary; required for incidence or causal claims
Application exceptions: Unverified event-specific timing or denominators do not mean absence of harm in 0/5, recovery or rechallenge.
Why this condition is needed: This prevents the 5 efficacy completers and 14-day treatment from automatically becoming harm denominators and follow-up.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N26 · Can harm comparisons, concurrent treatments and alternative causes be established?

Required materials and conditions: Harms comparator, baseline events, simultaneous exposures, concurrent treatments, alternative explanations and adjustment
Conditions for verification: Check actual comparators and event-specific baseline/concurrent exposures and alternative explanations in original material, separating them from causal attribution to oil.
Requirement and applicability: Supplementary; required for comparative or causal harms
Application exceptions: Absent information on alternative causes does not mean none existed. Do not import external background incidence.
Why this condition is needed: This prevents uncontrolled efficacy data or underlying-disease risk from becoming an oil-induced risk increase.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N27 · Is the scope of harm collection, omission, losses and disclosure established?

Required materials and conditions: Collection of all events, spontaneous reporting, detection, nonreporting, follow-up losses and exclusions
Conditions for verification: Check harm collection/detection, omissions, follow-up losses and analysis exclusions by original sections actually read for the exposure.
Requirement and applicability: Supplementary; required for safety claims
Application exceptions: While external full texts remain unread, do not establish whole-paper failure of collection or disclosure.
Why this condition is needed: This prevents gaps in retained harm summaries from becoming whole-paper nonreporting or proof of safety.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N28 · What is the scope of independent harms material, long-term observation and vulnerable populations?

Required materials and conditions: Unique harms families, product matching, long-term/rare events and vulnerable-population follow-up
Conditions for verification: Establish independent harms identity, exposure/product matching and long-term/vulnerable-population follow-up from actual material, distinguishing recitations and unestablished replication counts.
Requirement and applicability: Supplementary; required for replication or expanded safety
Application exceptions: Do not require all rare-harm research for the current narrow eradication observation. This condition concerns replication and population-extension claims.
Why this condition is needed: This prevents repeated warning wording from being counted as independent events or a short oil pilot from being extended to overall safety.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N29 · Does the wording distinguish warning, signal, comparative risk and causality?

Required materials and conditions: Events, comparator, denominator, timing, alternative explanations and the level of the original warning for the same exposure
Conditions for verification: Link the nature of the original treatment-replacement warning with unverified actual harm material, distinguishing signals, comparative risk, causality and individual instructions.
Requirement and applicability: Supplementary; required for safety or causal harms
Application exceptions: Distinguish checking interpretation boundaries permitted by the material from establishing actual harm information.
Why this condition is needed: This prevents the original warning from being converted to a new safety grade, confirmed causal harm or individual intake instruction.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

N30 · Are original C46, Warning, all axes, Korean/English text and correction separated from new states?

Required materials and conditions: Whole original summary, original data types, both languages/axes, correction, URLs and empty subclaims
Conditions for verification: Retain C46, Warning, all axes, all Korean/English fields, correction, citations and empty subclaims as original typed content, separating them from condition states and current reading.
Requirement and applicability: Required
Application exceptions: The original verdict is a historical quotation; do not create a new clinical reassessment or efficacy/safety grade.
Why this condition is needed: This prevents existing grades/axes or generic English verification wording from automatically satisfying new conditions.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

What the statuses mean

Met: The stated material, observation or boundary was checked within limits. Adverse observations are retained; this does not approve efficacy, safety or full-text reading.
Partly verified: Some retained information was checked, but material or conditions required by the criterion remain unverified.
Unverified: The criterion cannot be established in the retained record. This does not mean 0 studies, an effect of 0 or absence of harm.
Not reported: This is limited to a specific material or section actually read. It is not extended to nonreporting in an entire external paper.
Inaccessible: This is limited to an actual failed access attempt. It was not assigned to clinical materials in this conversion.
Not applicable: This is limited to a specific application exception. It does not substitute for unread material.
Review incomplete: Remaining comparison work and its reason are stated separately. This is distinguished from unverified material.
Conflicting data: This is limited to genuinely incompatible comparisons of the same question, time point and analysis.

Change history

2026-10-26 · Public page/material version 1.0

The public view and materials were prepared from the existing 30 items. No new clinical search, verification-state change or scoring was performed.

The stored-material review date (2026-10-06) and original evidence cut-off (2026-09-08) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which formulation, population and eradication question are being reviewed?

Current findings: This is an uncontrolled observation of steam-distilled garlic-oil monotherapy at 4 mg, 4 times daily for 14 days in adults with H. pylori-positive dyspepsia. The endpoint is negative results on both post-treatment UBT assessments; quantitative UBT with raw garlic and combination antibiotic regimens are excluded context.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The original claim, claim conditions and selected question are linked. This verifies the question’s identity and formulation/endpoint boundary, rather than eradication efficacy.
Reason for missing information: Gaps concerning eradication effects, product specifications, enrollment denominators and test intervals remain in the items below.
Required materials and conditions: Original locations for the claim, formulation, administration, population, eradication definition, comparison and timing
Materials to obtain first: Original locations for the claim, formulation, administration, population, eradication definition, comparison and timing
Further research: When a different formulation or antibiotic adjunct is considered as a new question, first establish its direct original material and comparison boundaries.
Remaining uncertainty: Gaps concerning eradication effects, product specifications, enrollment denominators and test intervals remain in the items below.
Conditions for verification: Link the original verdict claim and claim conditions to eradication defined by two negative UBT assessments with steam-distilled oil monotherapy, and state the excluded formulations and endpoints.
Why this condition is needed: This prevents garlic as a whole or changes in UBT values from replacing the oil-monotherapy eradication question.
Application exceptions: Checking the question boundary does not verify efficacy. Raw garlic and combination antibiotic regimens are retained as excluded context.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N02 · Can the study families of the two reports and their restatements be distinguished?

Current findings: There are 2 citations and linked summaries for the McNulty2001 oil report, PMID11683929, and Zardast2016 raw-garlic report, PMID27761418/PMC5052411. Evidence summaries, citations and Korean/English/synthesis texts restate each report.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The formulations, results and citations of the two retained reports were linked, but original identities for registration, follow-up reports and unique trials were not checked.
Reason for missing information: Global unique-trial and participant counts are null. The two evidence summaries and two citations are not counted as four trials.
Required materials and conditions: Identity links between reports, citations, registration and follow-up reports from the same study
Materials to obtain first: Identity links between reports, citations, registration and follow-up reports from the same study
Further research: In an authorized update, link registrations, original trials and follow-up reports, and group recitations from the same family.
Remaining uncertainty: Global unique-trial and participant counts are null. The two evidence summaries and two citations are not counted as four trials.
Conditions for verification: Check citation, formulation and endpoint links for the McNulty oil report and Zardast raw-garlic report; verify follow-up reports from the same trial through original study identity.
Why this condition is needed: This prevents Korean/English/synthesis texts and evidence/citation restatements from being added as independent replications.
Application exceptions: The two citations are clues to two reports; global unique-trial and participant counts remain unestablished.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N03 · Which summaries, citations and external materials were actually read?

Current findings: The retained Korean/English summaries, evidence tables, citations and correction records were actually read. PubMed, DOI and PMCID are gateway clues; external abstracts/full texts, appendices and registrations remain unread, with access not attempted.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Exact locations, original typed values and identity of local reading were separated from unread external materials for each material.
Reason for missing information: Current external responses, downloads, original paper bytes and access dates were not checked. These are not labeled inaccessible.
Required materials and conditions: Acquisition, actual reading, original locations, dates, hashes and original-material gateways for each material
Materials to obtain first: Acquisition, actual reading, original locations, dates, hashes and original-material gateways for each material
Further research: If full texts or appendices are read in a separately authorized update, add actual sections, dates and original identities.
Remaining uncertainty: Current external responses, downloads, original paper bytes and access dates were not checked. These are not labeled inaccessible.
Conditions for verification: Link the actual locations, values and identity of the retained summaries read, and separately record actual access to and reading of external abstracts, full texts, appendices and registrations.
Why this condition is needed: This prevents PubMed, DOI or PMCID links and historical verification wording from becoming current full-text reading.
Application exceptions: Access not attempted is not inaccessible. Reading in this conversion is limited to all fields of the retained summary.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N04 · Which H. pylori-positive adult population do the 5 completers represent?

Current findings: S1 concerns 5 adult completers with H. pylori-positive dyspepsia. S2 reports 15 people with raw garlic; they are not combined as S1’s recruited population or the same completers.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Disease, adulthood, dyspepsia and the completer scope are retained. Original data on diagnostic details, eligibility and representativeness remain insufficient.
Reason for missing information: The retained summary does not provide age distributions, H. pylori confirmation methods, dyspepsia definitions, eligibility, baseline characteristics or recruiting institutions/routes.
Required materials and conditions: Diagnosis, dyspepsia, age, eligibility, baseline status and recruitment route
Materials to obtain first: Diagnosis, dyspepsia, age, eligibility, baseline status and recruitment route
Further research: Application to another population requires direct research with that population, the same formulation and an eradication endpoint.
Remaining uncertainty: The retained summary does not provide age distributions, H. pylori confirmation methods, dyspepsia definitions, eligibility, baseline characteristics or recruiting institutions/routes.
Conditions for verification: Compare the original study’s H. pylori confirmation method, dyspepsia definition, eligibility, baseline characteristics and recruited population with the selected target population.
Why this condition is needed: This prevents observations in a very small completer group from being extended to all infected or asymptomatic people.
Application exceptions: Unverified recruitment information does not mean recruitment did not occur. The 15 people receiving raw garlic are not combined into the same sample.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N05 · Are the ingredients and product identity of steam-distilled garlic-oil capsules established?

Current findings: S1 uses steam-distilled garlic-oil capsules made from Allium sativum L. clove essential oil; sulfur-compound specifications are unverified. Raw garlic, powder, AGE and allicin are not interchangeable.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Raw material, formulation and route are stated, but actual sulfur-compound specifications and batch/manufacturing/content records were not verified.
Reason for missing information: Product name, manufacturer, batch, sulfur-compound composition/content, standardization and batch equivalence are absent from the retained record.
Required materials and conditions: Raw material, steam-distillation process, sulfur-compound specifications, manufacturing/batch and content testing
Materials to obtain first: Raw material, steam-distillation process, sulfur-compound specifications, manufacturing/batch and content testing
Further research: Record product specifications and batches in subsequent comparisons and distinguish results from other formulations.
Remaining uncertainty: Product name, manufacturer, batch, sulfur-compound composition/content, standardization and batch equivalence are absent from the retained record.
Conditions for verification: Check steam-distilled essential oil, capsules, sulfur-compound specifications and batch/content of the actual administered product against original product records.
Why this condition is needed: This prevents essential oil from being treated as equivalent to allicin, raw garlic or AGE.
Application exceptions: The name garlic oil alone does not establish sulfur-compound specifications or equivalence with other products.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N06 · Do 4 mg, 4 times daily for 14 days establish actual intake and adherence?

Current findings: The retained prescribed regimen is oil 4 mg, 4 times daily (16 mg/day) for 14 days. S2’s raw garlic 3 g, 2 times daily for 3 days is not used as an equivalent oil dose or direct dose comparison.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Prescribed dose, frequency and duration were checked. Material establishing actual intake, adherence, discontinuation and product content is unavailable.
Reason for missing information: 16 mg/day is a retained quotation rather than a new calculation. Actual intake, adherence and dose response within the same formulation remain unverified.
Required materials and conditions: Prescribed dose, actual administered dose, frequency, adherence, discontinuation and product content
Materials to obtain first: Prescribed dose, actual administered dose, frequency, adherence, discontinuation and product content
Further research: An optimal-dose claim separately requires direct dose comparisons with the same specified product and eradication assessment.
Remaining uncertainty: 16 mg/day is a retained quotation rather than a new calculation. Actual intake, adherence and dose response within the same formulation remain unverified.
Conditions for verification: Separately check the oil prescription of 4 mg, 4 times daily for 14 days and actual intake/adherence/discontinuation, without converting doses between formulations.
Why this condition is needed: This retains the original 16 mg/day while separating prescription from actual intake.
Application exceptions: 16 mg/day is quoted from the retained record. No new dose calculation or equivalence conversion to grams of raw garlic is made.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N07 · How far are concomitant and rescue treatments in the oil-monotherapy observation established?

Current findings: S1 is a garlic-oil monotherapy pilot. The allicin-containing antibiotic 4-drug regimen is described only as a separate combination prescription; there is no evidence/citation report 3.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The monotherapy-versus-combination boundary was checked. This does not establish every concomitant treatment, rescue treatment or change in S1.
Reason for missing information: The retained summary lacks detailed records on actual antibiotics, acid suppressants, other medication, rescue treatment, adherence and their analytical impact.
Required materials and conditions: Antibiotics, acid suppressants, other treatments, intake changes, rescue treatment and adherence records
Materials to obtain first: Antibiotics, acid suppressants, other treatments, intake changes, rescue treatment and adherence records
Further research: When comparing causal effects of oil, prospectively record background treatment, changes and rescue treatment.
Remaining uncertainty: The retained summary lacks detailed records on actual antibiotics, acid suppressants, other medication, rescue treatment, adherence and their analytical impact.
Conditions for verification: Check actual concomitant/rescue treatment, changes and analytical handling during observation, separating them from adjunct effects in an antibiotic 4-drug regimen.
Why this condition is needed: This prevents results from combination antibiotic regimens from being attributed to oil monotherapy.
Application exceptions: The retained monotherapy boundary does not establish every concomitant or rescue-treatment detail.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N08 · Is there a concurrent comparator, and which differences can be compared?

Current findings: S1 has no concurrent comparator. Eradication 0/5 among completers is an oil-monotherapy observation, rather than a placebo-adjusted difference, between-group RR/CI or antibiotic noninferiority estimate.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The lack of a concurrent comparator and the observation’s scope are stated. Comparator data needed to answer between-group efficacy conditions are unavailable.
Reason for missing information: There are no concurrent-comparator outcomes, matched time points, background-treatment records or eradication event tables; between-group causal effects are not estimated.
Required materials and conditions: Actual comparator, background treatment, time points, population and comparison of interest
Materials to obtain first: Actual comparator, background treatment, time points, population and comparison of interest
Further research: Causal or replacement claims require an appropriate concurrent comparison with the same formulation and confirmed-eradication endpoint.
Remaining uncertainty: There are no concurrent-comparator outcomes, matched time points, background-treatment records or eradication event tables; between-group causal effects are not estimated.
Conditions for verification: Check the existence and content of a concurrent comparator for the eradication result; do not convert a single-arm observation into a between-group difference, RR or noninferiority result.
Why this condition is needed: This prevents failure in 0/5 from becoming a placebo-adjusted null effect or noninferiority to antibiotics.
Application exceptions: The current uncontrolled observation is retained. Distinguish the absence of a comparator from a future comparative design.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N09 · When were the two UBT assessments performed after 14 days of treatment?

Current findings: Oil treatment for 14 days and 2 post-treatment UBT assessments are retained. Exact intervals between test visits remain unverified.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Treatment duration and the number of tests were checked. The 14-day treatment is not described as the exact follow-up duration through both tests.
Reason for missing information: The retained summary does not establish dates of the two tests, intervals after treatment end, concomitant-treatment withdrawal before testing or long-term eradication follow-up.
Required materials and conditions: Treatment end, the two test visits, intervals, concomitant-treatment withdrawal and follow-up schedule
Materials to obtain first: Treatment end, the two test visits, intervals, concomitant-treatment withdrawal and follow-up schedule
Further research: Subsequent research should separately plan and report treatment end and eradication-confirmation time points.
Remaining uncertainty: The retained summary does not establish dates of the two tests, intervals after treatment end, concomitant-treatment withdrawal before testing or long-term eradication follow-up.
Conditions for verification: Link 14 days of treatment to the actual time points, intervals and pretest concomitant-treatment conditions of the two post-treatment UBT visits.
Why this condition is needed: This prevents 14 days of treatment from becoming the exact follow-up duration through eradication confirmation.
Application exceptions: Do not fill the retained two-test statement with particular dates or confirmed long-term persistence.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N10 · Are the two-negative-UBT eradication definition and test thresholds established?

Current findings: The selected eradication endpoint is the proportion negative on both post-treatment UBT assessments. S2’s quantitative UBT change is not an eradication endpoint; eradication rate was not assessed.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The rule combining two negative tests and its difference from quantitative change are stated. Test details and negative thresholds were not established.
Reason for missing information: UBT type, threshold, testing/sampling conditions, assessment method and participant-level original values for both tests are absent from the retained record.
Required materials and conditions: UBT type, negative threshold, assessment, testing conditions and the rule combining both tests
Materials to obtain first: UBT type, negative threshold, assessment, testing conditions and the rule combining both tests
Further research: Subsequent eradication research should state negative-result rules and testing conditions.
Remaining uncertainty: UBT type, threshold, testing/sampling conditions, assessment method and participant-level original values for both tests are absent from the retained record.
Conditions for verification: Check the original study’s two-negative-post-treatment-UBT definition, test method, thresholds and assessment/conditions, separating them from decreased values.
Why this condition is needed: This prevents quantitative UBT decreases or suppression from replacing confirmed eradication.
Application exceptions: Both tests being negative is the selected endpoint. Diagnostic accuracy and symptom improvement are separate questions.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N11 · What was observed in completer eradication 0/5 and no suppression?

Current findings: The retained S1 result is eradication 0/5 with no suppression. The adverse observation that all completers failed is retained and is not replaced by S2’s UBT decrease.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The current result, completer denominator and uncontrolled boundary were linked. This preserves a failure observation rather than a precise E0, replicated refutation RX or verdict of ineffectiveness.
Reason for missing information: Between-group comparison, precision and original event tables remain unverified. No new proportion, CI, P or RR is created.
Required materials and conditions: Two tests per participant, eradication/suppression results and endpoint-specific analysis tables
Materials to obtain first: Two tests per participant, eradication/suppression results and endpoint-specific analysis tables
Further research: Compare additional evidence using the same formulation and confirmed-eradication endpoint while retaining the earlier failure.
Remaining uncertainty: Between-group comparison, precision and original event tables remain unverified. No new proportion, CI, P or RR is created.
Conditions for verification: Retain the original eradication 0/5 and no-suppression endpoint and completer denominator, distinguishing the single-arm failure observation from a between-group null effect or replicated refutation.
Why this condition is needed: This prevents an adverse direct observation from being erased by positive raw-garlic values or promoted to a precise null effect.
Application exceptions: 0/5 and no suppression are retained observations. Do not create a new proportion, RR, CI, P or replicated refutation.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N12 · Can the 5 completers be distinguished from original enrollment and analysis denominators?

Current findings: The established S1 denominator is 5 completers; original enrollment remains unverified. S2’s 15 people are not added to create a participant total or common analysis denominator.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The original completer denominator and unverified enrollment denominator were separately retained. The complete recruitment-to-analysis flow cannot be established.
Reason for missing information: Counts at initial recruitment, enrollment, exposure, testing and analysis, denominators for both UBT assessments and the ITT denominator remain unverified.
Required materials and conditions: Participant counts and flow through recruitment, enrollment, exposure, testing, completion and analysis
Materials to obtain first: Participant counts and flow through recruitment, enrollment, exposure, testing, completion and analysis
Further research: Subsequent research should disclose participant flow from recruitment through both tests and analysis.
Remaining uncertainty: Counts at initial recruitment, enrollment, exposure, testing and analysis, denominators for both UBT assessments and the ITT denominator remain unverified.
Conditions for verification: Link the completer denominator of 0/5 with original recruitment, exposure, testing and analysis denominators and the original counts at each stage.
Why this condition is needed: This prevents 5 completers from becoming 5 initially recruited participants or an ITT denominator of 5.
Application exceptions: Do not combine participants with the 15 people receiving raw garlic. Unavailable denominators remain null or unverified.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N13 · Are losses, missed tests, missingness and completer selection established?

Current findings: The retained summary supplies only 5 completers and an unverified original enrollment denominator. Reasons for losses, missed tests or missingness and handling rules were not established.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Completer observations exist, but original participant-flow and missing-data material needed to establish this condition is unavailable.
Reason for missing information: Do not fill losses with 0 or missingness with 0, or assign PP/ITT. This does not establish absence of reporting in the whole paper.
Required materials and conditions: Reasons for losses, missed tests, missingness, completion criteria, analytical handling and original participant flow
Materials to obtain first: Reasons for losses, missed tests, missingness, completion criteria, analytical handling and original participant flow
Further research: Subsequent research should prospectively define missing-data handling and analysis populations, separating them from completer-only results.
Remaining uncertainty: Do not fill losses with 0 or missingness with 0, or assign PP/ITT. This does not establish absence of reporting in the whole paper.
Conditions for verification: Compare discontinuation, missed UBT assessments, reasons for losses and their eradication-analysis handling with original participant flow and the analysis plan.
Why this condition is needed: This prevents an unverified enrollment denominator from becoming 0 losses or an analysis without missing data.
Application exceptions: The term completer alone does not establish a PP or ITT analysis method.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N14 · What design governs recruitment and selection in the uncontrolled pilot?

Current findings: S1 is an uncontrolled pilot; the retained text states that randomization and a concurrent comparator were absent. Detailed recruitment, selection and baseline methods are absent from the current summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The uncontrolled design and causal limitations were checked. Randomization, concealment and baseline balance were not attributed.
Reason for missing information: Original methods for single-arm recruitment, convenience selection, baseline status and eligibility remain unverified. Crossover or cluster designs are not inferred.
Required materials and conditions: Single-arm design, recruitment/selection, baseline status, allocation status and original methods
Materials to obtain first: Single-arm design, recruitment/selection, baseline status, allocation status and original methods
Further research: Research on causal effects should prospectively state an appropriate comparative design and the allocation/selection process.
Remaining uncertainty: Original methods for single-arm recruitment, convenience selection, baseline status and eligibility remain unverified. Crossover or cluster designs are not inferred.
Conditions for verification: Check the actual single-arm recruitment and selection process in the original methods and state causal limitations of observation without randomization or a concurrent comparator.
Why this condition is needed: This prevents the pilot label from conferring random allocation or baseline balance.
Application exceptions: The retained study is uncontrolled; randomization/allocation is not verified. Parallel, crossover or cluster details are not inferred.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N15 · Are standardization and blinding of UBT measurement and assessment established?

Current findings: The retained summary did not establish assessors, blinding, sampling standardization or error management for the two UBT assessments. The name UBT does not verify these procedures.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The test name and two-negative definition alone cannot establish measurement standardization or blinding.
Reason for missing information: Original sections on test type, sampling/testing conditions, assessors, blinding and error/indeterminate handling are needed. External full texts remain unread.
Required materials and conditions: Consistent test method, sampling/testing conditions, assessors, blinding and error management
Materials to obtain first: Consistent test method, sampling/testing conditions, assessors, blinding and error management
Further research: Subsequent research should standardize testing and assessment, recording assessment blinding where it can be established.
Remaining uncertainty: Original sections on test type, sampling/testing conditions, assessors, blinding and error/indeterminate handling are needed. External full texts remain unread.
Conditions for verification: Check testing, sampling and assessment conditions and assessor blinding/error management for both UBT assessments against original procedures.
Why this condition is needed: This prevents an objective test name from implying that measurement error or assessment bias is resolved.
Application exceptions: UBT use itself does not establish assessor blinding or matching conditions.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N16 · Which analysis and effect of interest do completer results answer?

Current findings: 0/5 is a single-arm completer eradication observation. The retained text states that between-group RR/CI cannot be calculated and provides no analysis name, ITT/PP or missing-data details.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The actual observation population and absence of concurrent comparison were checked. Planned effects of interest and analysis rules could not be compared.
Reason for missing information: Participant-level tests and event tables, definitions of the analysis population, missed-test handling and the original plan remain unverified. The result is not converted into a placebo-adjusted estimate.
Required materials and conditions: Analysis population, participant event tables, ITT/PP, within-/between-group distinctions and analysis plan
Materials to obtain first: Analysis population, participant event tables, ITT/PP, within-/between-group distinctions and analysis plan
Further research: A subsequent comparison should define its effect of interest, analysis population and missing-data handling before results are reported.
Remaining uncertainty: Participant-level tests and event tables, definitions of the analysis population, missed-test handling and the original plan remain unverified. The result is not converted into a placebo-adjusted estimate.
Conditions for verification: Establish that the original 0/5 is a single-arm completer observation and link actual analysis rules and test-specific event tables with the original plan/results.
Why this condition is needed: This prevents single-arm completer results from being transferred to randomized-assignment effects or placebo-adjusted estimates.
Application exceptions: No concurrent comparator is available to calculate between-group RR/CI. Do not fill an unverified analysis name.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N17 · Are the eradication observation’s precision and important-difference criterion established?

Current findings: Retain the original S1 statement that between-group RR/CI cannot be calculated without a concurrent comparator. Single-arm CI, P and important-difference criteria are also absent from the retained summary.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Reported event counts alone cannot establish comparative precision, equivalence, confirmatory strength or an important difference, and new calculations are not authorized.
Reason for missing information: Originally reported intervals, justified important differences and between-group contrast data were not checked. Do not reverse-calculate a new confidence interval, proportion, P or required n from 0/5.
Required materials and conditions: Endpoint-specific events/denominators, originally reported intervals, justified important differences and concurrent comparison
Materials to obtain first: Endpoint-specific events/denominators, originally reported intervals, justified important differences and concurrent comparison
Further research: Plan precision for future questions using a justified important difference and an appropriate design; do not invent a minimum n.
Remaining uncertainty: Originally reported intervals, justified important differences and between-group contrast data were not checked. Do not reverse-calculate a new confidence interval, proportion, P or required n from 0/5.
Conditions for verification: Compare originally reported eradication estimates, intervals, denominators and grounds for an important difference; do not attribute between-group precision or equivalence to uncontrolled results.
Why this condition is needed: This prevents very small failure observations or significance alone from establishing confirmatory strength, equivalence or required sample size.
Application exceptions: Retain that between-group RR/CI cannot be calculated. Do not newly calculate single-arm CI or P; leave them unverified.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N18 · Were planned endpoints compared with the registration, protocol and actual report?

Current findings: The native registration values for S1 and S2 each state that confirmation was not possible. External registrations, protocols and analysis plans were not read in this conversion.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Plan material for comparing prespecified endpoints, time points and denominators with actual reports is unavailable; a current registration lookup was not performed.
Reason for missing information: Do not convert this to confirmed absence of registration or confirmed selective reporting. Exact registration identity, plans and reasons for changes remain unverified.
Required materials and conditions: Registration ID, protocol, analysis plan, endpoint/time-point changes and results
Materials to obtain first: Registration ID, protocol, analysis plan, endpoint/time-point changes and results
Further research: In a separate update, acquire registration, plans and change histories and review the linked results.
Remaining uncertainty: Do not convert this to confirmed absence of registration or confirmed selective reporting. Exact registration identity, plans and reasons for changes remain unverified.
Conditions for verification: Compare original registration/plan definitions of eradication, the two tests and analysis populations with actual results by location, distinguishing portions that could not be compared.
Why this condition is needed: This prevents could not confirm from becoming confirmed nonregistration or selective reporting.
Application exceptions: External registration and original plans remain unread in this conversion. The historical original-review date is not a plan-comparison date.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N19 · Is the UBT decrease in 15 people receiving raw garlic replication of oil eradication?

Current findings: S2 reports an uncontrolled before-after quantitative UBT decrease in 15 people receiving raw garlic 3 g, 2 times daily for 3 days; eradication rate was not assessed. Its formulation and endpoint differ from S1’s oil for 14 days, 5 completers and eradication 0/5.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The two reports’ retained formulation, duration, denominator and endpoint differences were linked. S2 was not combined as oil-eradication success, refutation or independent replication.
Reason for missing information: Global trial families and overlapping/independent participant identities remain separately unverified. The exact decrease, CI/P are also absent from the retained summary.
Required materials and conditions: Links between the two reports’ formulations, doses, timing, denominators, endpoints and families
Materials to obtain first: Links between the two reports’ formulations, doses, timing, denominators, endpoints and families
Further research: Independently identify replication of the same oil-eradication question using the same formulation, definition and time points.
Remaining uncertainty: Global trial families and overlapping/independent participant identities remain separately unverified. The exact decrease, CI/P are also absent from the retained summary.
Conditions for verification: Compare S2’s raw garlic 3 g, 2 times daily for 3 days, 15 people and quantitative UBT change/unassessed eradication with S1’s oil, 14 days, 5 completers and eradication, to establish differences in directness.
Why this condition is needed: This prevents a quantitative decrease with raw garlic from being combined as oil-monotherapy eradication success.
Application exceptions: An ancillary report with another formulation and endpoint is retained. It is not classified as conflict within the same question or independent replication.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N20 · Does the record answer dose optimization, persistent eradication or other populations?

Current findings: The retained two reports did not establish direct dose comparisons for the same oil, persistent eradication after stopping or prespecified subgroup evidence.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: A single-dose 14-day observation and a 3-day report using another formulation cannot establish optimal dose, long-term persistence or effects in other populations.
Reason for missing information: Even exact test follow-up intervals remain unverified. Direct material is required for extension questions only; this does not establish absence of all research.
Required materials and conditions: Direct dose comparisons using the same formulation, post-discontinuation follow-up and subgroup/interaction evidence
Materials to obtain first: Direct dose comparisons using the same formulation, post-discontinuation follow-up and subgroup/interaction evidence
Further research: When extension questions are requested, separate them into appropriate dose, follow-up and population designs.
Remaining uncertainty: Even exact test follow-up intervals remain unverified. Direct material is required for extension questions only; this does not establish absence of all research.
Conditions for verification: Check direct comparisons/follow-up and prespecified subgroup evidence using the same formulation for optimal-dose, persistent-eradication or other-population claims.
Why this condition is needed: This prevents a short pilot at one dose from being extended to optimal dose or long-term persistence.
Application exceptions: Do not make all long-term and subgroup research mandatory for the narrow 14-day observation.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N21 · Do UBT and eradication observations also answer antibiotic replacement and clinical events?

Current findings: The retained text states that in-vitro antibacterial activity or decreased UBT values cannot be advertised as successful eradication or antibiotic replacement. The allicin-containing antibiotic 4-drug regimen is boundary narrative about a combination prescription.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The selected endpoint and clinical/replacement boundaries were checked. Direct comparative material on antibiotic replacement, ulcers, bleeding, cancer or symptoms is absent from the retained record.
Reason for missing information: Antibiotic-combination narrative is not report 3. Clinical-event results, the frequency of treatment delay, noninferiority and direct replacement evidence remain unverified.
Required materials and conditions: Separate comparisons for eradication versus symptoms, ulcers, bleeding, cancer and treatment replacement
Materials to obtain first: Separate comparisons for eradication versus symptoms, ulcers, bleeding, cancer and treatment replacement
Further research: Antibiotic replacement and clinical events require separate questions, appropriate direct comparisons and safety follow-up.
Remaining uncertainty: Antibiotic-combination narrative is not report 3. Clinical-event results, the frequency of treatment delay, noninferiority and direct replacement evidence remain unverified.
Conditions for verification: Distinguish selected eradication from value changes, symptoms, clinical events and antibiotic replacement; require direct comparative evidence for each extension claim.
Why this condition is needed: This prevents UBT values or antibacterial mechanisms from being extended to antibiotic replacement or ulcer/cancer prevention.
Application exceptions: Do not require every cancer-prevention trial for the selected eradication endpoint. Do not create a new report solely from the antibiotic 4-drug narrative.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N22 · What are the original review/correction dates and the scope of current reading/searching?

Current findings: The original verdict-review date is 2026-09-08 and the retained English correction is dated 2026-09-14. Current reading concerns the 2026-10-06 retained summaries; no new clinical search or comprehensive external registration/retraction/correction lookup was performed.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Verdict, correction and current-reading dates were linked. Material establishing the original search cut-off/scope and current external publication status is unavailable.
Reason for missing information: The original verdict-review date is not used as a current access date or comprehensive search cut-off. No new search does not mean 0 studies.
Required materials and conditions: Review/correction dates, input identities, actual reading and search/registration/retraction checks
Materials to obtain first: Review/correction dates, input identities, actual reading and search/registration/retraction checks
Further research: In an authorized evidence update, record search scope, dates and unpublished/registration/correction status as a separate event.
Remaining uncertainty: The original verdict-review date is not used as a current access date or comprehensive search cut-off. No new search does not mean 0 studies.
Conditions for verification: Separate the 2026-09-08 original review, 09-14 correction record and current reading of retained summaries; accurately state the scope of searches and comprehensive registration/correction/retraction checks.
Why this condition is needed: This prevents a retained summary from being described as a current comprehensive literature review or a search returning 0 results.
Application exceptions: The original verdict-review date is neither the current access date nor a search cut-off.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N23 · How far are funding, product provision and author interests established?

Current findings: S1 states that funding and product provision are unverified; S2 states academic research with details unverified. English funding wording and the original I1 axis are retained as historical text.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Original sections containing individual funding, product-provision and author/institution declarations were not read, so independent funding or absence of interests was not verified.
Reason for missing information: Academic research, I1 and generic English assessed wording are not current evidence of independence. Employment/patents, product support, declarations and institutions remain unverified.
Required materials and conditions: Original-paper funding, product provision, employment/patents, interest declarations and institutions
Materials to obtain first: Original-paper funding, product provision, employment/patents, interest declarations and institutions
Further research: In a separate update, check funding, product and author relationships without automatically excluding results or approving them as unbiased.
Remaining uncertainty: Academic research, I1 and generic English assessed wording are not current evidence of independence. Employment/patents, product support, declarations and institutions remain unverified.
Conditions for verification: Link each report’s funding, product provision and author/institution declarations to original sections; do not attribute unsupported independence claims.
Why this condition is needed: This prevents historical I1 and generic English wording from being used as proof of independent funding or absence of interests.
Application exceptions: S2’s academic-research wording does not verify independent funding. Unverified interests do not establish absence of involvement.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N24 · Are the original warning and actually collected adverse events distinguished?

Current findings: The original warning states that replacing antibiotic-based treatment and eradication confirmation with garlic may delay management of ulcer, bleeding and gastric-cancer risk. Actual adverse-event counts in S1 are absent from the retained summary.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The warning was checked, but event definitions, collection, severity and discontinuation for the same oil administration cannot be verified. The warning is not presented as observed events.
Reason for missing information: Numbers of affected people/events, collection methods, discontinuation and severity for this oil remain unverified. Efficacy 0/5 is not harms 0/5.
Required materials and conditions: Event definitions, collection, severity and discontinuation for the same oil exposure, and the original warning
Materials to obtain first: Event definitions, collection, severity and discontinuation for the same oil exposure, and the original warning
Further research: When studying harms with the same formulation, separately design event definitions, collection and discontinuation procedures from efficacy endpoints.
Remaining uncertainty: Numbers of affected people/events, collection methods, discontinuation and severity for this oil remain unverified. Efficacy 0/5 is not harms 0/5.
Conditions for verification: Check actual adverse-event definitions, systematic/spontaneous collection, severity and discontinuation for oil exposure, separating them from the original treatment-replacement warning.
Why this condition is needed: This prevents a warning about delayed management after replacing treatment from becoming bleeding or cancer events observed in the pilot.
Application exceptions: The original warning is retained. Absence of adverse-event counts in an efficacy summary does not mean no events.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N25 · Are harm-exposure, onset/recovery timing and denominators available?

Current findings: Oil treatment for 14 days and 5 efficacy completers are retained, but denominators for harms assessment, onset/recovery, exposure/follow-up time and rechallenge data are absent from the retained summary.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The efficacy denominator and treatment duration cannot be inherited as data for harm incidence, follow-up or temporal sequence.
Reason for missing information: Exposed people, affected people/event counts, follow-up, discontinuation/recovery and rechallenge remain unverified. Do not create new incidence or absence-of-harm proportions.
Required materials and conditions: Harms-assessed exposed people, affected people/event counts, observation periods, discontinuation/recovery and rechallenge
Materials to obtain first: Harms-assessed exposed people, affected people/event counts, observation periods, discontinuation/recovery and rechallenge
Further research: Collect exposure, events, follow-up and discontinuation information separately when observing harms with the same formulation.
Remaining uncertainty: Exposed people, affected people/event counts, follow-up, discontinuation/recovery and rechallenge remain unverified. Do not create new incidence or absence-of-harm proportions.
Conditions for verification: Link harm-exposure/event/recovery times with assessment denominators and follow-up in the same event material before interpreting frequency or temporal sequence.
Why this condition is needed: This prevents the 5 efficacy completers and 14-day treatment from automatically becoming harm denominators and follow-up.
Application exceptions: Unverified event-specific timing or denominators do not mean absence of harm in 0/5, recovery or rechallenge.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N26 · Can harm comparisons, concurrent treatments and alternative causes be established?

Current findings: S1’s uncontrolled design and the treatment-replacement warning are retained. A harms comparator, baseline events, simultaneous exposures and event-specific alternative explanations for the same oil were not established.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Without event material, comparisons or alternative causes, increased risk caused by oil or individual causation cannot be attributed.
Reason for missing information: Underlying-disease risk, other causes, concurrent treatments, baseline status and harms comparison/adjustment remain unverified. Background incidence is not extrapolated.
Required materials and conditions: Harms comparator, baseline events, simultaneous exposures, concurrent treatments, alternative explanations and adjustment
Materials to obtain first: Harms comparator, baseline events, simultaneous exposures, concurrent treatments, alternative explanations and adjustment
Further research: Comparative-harm questions should record an appropriate comparator and event-specific baseline and simultaneous exposures.
Remaining uncertainty: Underlying-disease risk, other causes, concurrent treatments, baseline status and harms comparison/adjustment remain unverified. Background incidence is not extrapolated.
Conditions for verification: Check actual comparators and event-specific baseline/concurrent exposures and alternative explanations in original material, separating them from causal attribution to oil.
Why this condition is needed: This prevents uncontrolled efficacy data or underlying-disease risk from becoming an oil-induced risk increase.
Application exceptions: Absent information on alternative causes does not mean none existed. Do not import external background incidence.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N27 · Is the scope of harm collection, omission, losses and disclosure established?

Current findings: The two evidence summaries in the retained record lack detailed tables on harm collection, omission, losses or detection differences. External original papers and appendices remain unread.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The material could not be established from the summary; collection, disclosure and missingness across the entire original paper were not reviewed.
Reason for missing information: Original adverse-event tables, recruitment/reporting/follow-up systems, discontinuation reasons and disclosure of all events remain unverified. Do not establish whole-paper nonreporting or absence of events.
Required materials and conditions: Collection of all events, spontaneous reporting, detection, nonreporting, follow-up losses and exclusions
Materials to obtain first: Collection of all events, spontaneous reporting, detection, nonreporting, follow-up losses and exclusions
Further research: In a separate update, link harms tables, discontinuation reasons and collection plans and review the scope of missing information.
Remaining uncertainty: Original adverse-event tables, recruitment/reporting/follow-up systems, discontinuation reasons and disclosure of all events remain unverified. Do not establish whole-paper nonreporting or absence of events.
Conditions for verification: Check harm collection/detection, omissions, follow-up losses and analysis exclusions by original sections actually read for the exposure.
Why this condition is needed: This prevents gaps in retained harm summaries from becoming whole-paper nonreporting or proof of safety.
Application exceptions: While external full texts remain unread, do not establish whole-paper failure of collection or disclosure.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N28 · What is the scope of independent harms material, long-term observation and vulnerable populations?

Current findings: Independent oil-harm families, long-term/rare events and vulnerable-population material could not be established in the retained summary. Korean/English/synthesis warning restatements and the raw-garlic report are not counted as independent oil-harm events.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: Without independent identities and appropriate follow-up for the same product/events, replicated or expanded safety cannot be verified.
Reason for missing information: This is unverified within an unsearched harms literature and unread-original-material scope. Do not invent event counts or long-term safety, or make all rare-event research mandatory.
Required materials and conditions: Unique harms families, product matching, long-term/rare events and vulnerable-population follow-up
Materials to obtain first: Unique harms families, product matching, long-term/rare events and vulnerable-population follow-up
Further research: Expanded safety questions require separate consideration of appropriate long-term and rare-event/vulnerable-population designs.
Remaining uncertainty: This is unverified within an unsearched harms literature and unread-original-material scope. Do not invent event counts or long-term safety, or make all rare-event research mandatory.
Conditions for verification: Establish independent harms identity, exposure/product matching and long-term/vulnerable-population follow-up from actual material, distinguishing recitations and unestablished replication counts.
Why this condition is needed: This prevents repeated warning wording from being counted as independent events or a short oil pilot from being extended to overall safety.
Application exceptions: Do not require all rare-harm research for the current narrow eradication observation. This condition concerns replication and population-extension claims.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2

N29 · Does the wording distinguish warning, signal, comparative risk and causality?

Current findings: The current warning is an interpretation boundary concerning potentially delayed management when validated treatment is replaced. No new verdict on direct oil-harm signals, comparative risk, causality or safety grade is created.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The level of the original warning was separated from unverified actual harm material. This checks a wording boundary rather than establishing clinical safety.
Reason for missing information: Events, denominators, comparators, timing and alternative explanations remain unverified. No individual intake instructions are added.
Required materials and conditions: Events, comparator, denominator, timing, alternative explanations and the level of the original warning for the same exposure
Materials to obtain first: Events, comparator, denominator, timing, alternative explanations and the level of the original warning for the same exposure
Further research: If direct harms material is added, review the level of wording within the same event, population and exposure boundaries.
Remaining uncertainty: Events, denominators, comparators, timing and alternative explanations remain unverified. No individual intake instructions are added.
Conditions for verification: Link the nature of the original treatment-replacement warning with unverified actual harm material, distinguishing signals, comparative risk, causality and individual instructions.
Why this condition is needed: This prevents the original warning from being converted to a new safety grade, confirmed causal harm or individual intake instruction.
Application exceptions: Distinguish checking interpretation boundaries permitted by the material from establishing actual harm information.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1

N30 · Are original C46, Warning, all axes, Korean/English text and correction separated from new states?

Current findings: Retain original C46, Warning, B/S/R1/I1/EX/B2/CX and all-axis Boolean/empty-string values, all Korean/English fields, 1 correction, 2 reports/2 citations, empty subclaims and URLs unchanged.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.
Why unverified: The complete identical bytes and original typed content of the current source, retained copy and inputs were linked. Historical verdicts and generic English wording were not inherited as new states, reading or scores.
Reason for missing information: No new efficacy/safety score, verdict, calculation or full-text reading was performed. Original empty values, unknowns and adverse results are retained.
Required materials and conditions: Whole original summary, original data types, both languages/axes, correction, URLs and empty subclaims
Materials to obtain first: Whole original summary, original data types, both languages/axes, correction, URLs and empty subclaims
Further research: If a correction or update is separately requested, retain the whole original text and distinguish the event, condition version and verdict decision.
Remaining uncertainty: No new efficacy/safety score, verdict, calculation or full-text reading was performed. Original empty values, unknowns and adverse results are retained.
Conditions for verification: Retain C46, Warning, all axes, all Korean/English fields, correction, citations and empty subclaims as original typed content, separating them from condition states and current reading.
Why this condition is needed: This prevents existing grades/axes or generic English verification wording from automatically satisfying new conditions.
Application exceptions: The original verdict is a historical quotation; do not create a new clinical reassessment or efficacy/safety grade.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.

Related sources S1 S2