Combined breathing added to standard care × DBP and HRV: evidence checklist

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich DBP/HRV claim is selected?Required	The selection is improved DBP or HRV. Preserve original grade D and the note that DBP was null and HRV varied by metric and study. Parent C with 50 points concerns 6-week SBP. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Selected claim, grade and note versus the parent SBP verdict	Material needed: The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhat outcomes are DBP and HRV?Required	Mittal covers 6-week SBP/DBP and HRV; Ghiya covers acute HRV. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Outcome definitions, units, timing, denominators and analyses	Material needed: Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionAre the populations the same?Required	Mittal is a standard-care adjunct trial in adults with hypertension on medication, with 91 randomized and 68 completed. Ghiya has an original 100 participants. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Trial eligibility, age, baseline medication and pressure/HRV	Material needed: Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWhat combined program was studied?Required	Mittal added 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing daily as a combined intervention. These identify the study and are not breathing instructions. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Preceding breathing, components, actual delivery and adherence	Material needed: Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWhat was each control?Required	Mittal compares an addition to standard care retaining medication and lifestyle management; Ghiya is an acute comparison with another pranayama. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Standard care, active control, contact and existing medication/lifestyle care	Material needed: Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre observation periods and measurement windows the same?Required	Mittal 6-week and Ghiya acute HRV observations have different windows. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Outcome periods, measurement timing and follow-up	Material needed: Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionAre randomized, completed, withdrawn and analysis populations the same?Required	Preserve original 91 randomized, 68 completed and parent-record 23 withdrawals/25.3% attrition. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Outcome-specific arm denominators, missingness and withdrawal reasons	Material needed: Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhat does null DBP mean?Required	Preserve Mittal DBP P>.05 and the selected note's null DBP result. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm DBP, between-group effects, CIs, exact P and models	Material needed: Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence. This records needed materials; no new research was executed.
9	Unverified	Full text not readStored summary read	N09 · Evidence conditionHow did Mittal HRV vary by measure?Required	Original explanations and the selected note record HRV varying by metric and study. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Measure list, units, directions, denominators and between-group estimates	Material needed: Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionWhat was Ghiya's acute HRV result?Required	Preserve Ghiya 100 participants, acute comparison with another pranayama and between-group null HRV. S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Active control, measure-specific estimates, denominators and models	Material needed: Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionCan parent SBP numbers be transferred?Required	SBP 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and existing crude difference -8.65 mmHg are parent SBP context. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	SBP versus DBP/HRV and final values versus adjusted changes	Material needed: Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionHow did DBP/HRV analyses handle missingness and baseline values?Required	The parent record retains complete-case analysis and unverified adjusted between-group effects/CIs. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Outcome-specific ITT/PP, adjustment, repeated models and sensitivity	Material needed: DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified. This records needed materials; no new research was executed.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionWere allocation, blinding and evaluation roles verified?Required	Preserve original designs described as a Mittal randomized adjunct trial and Ghiya acute comparison. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, concealment and participant/evaluator/analyst roles	Material needed: Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial. This records needed materials; no new research was executed.
14	Unverified	Full text not readStored summary read	N14 · Evidence conditionWere pressure/HRV measurement conditions and quality verified?Required	Each report records pressure or HRV outcomes. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Devices, resting conditions, repeats and signal quality	Material needed: Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionDoes registration wording establish prospective endpoints?Required	Mittal's original registration wording is CTRI/2023/11/059625; Ghiya says unverified. The parent record retains unverified formal prospective endpoints. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Registration, protocol, SAP, DBP/HRV hierarchy and changes	Material needed: Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered. This records needed materials; no new research was executed.
16	Unverified	Full text not readStored summary read	N16 · Evidence conditionWere precision and clinical meaning across measures verified?Required	Preserve null DBP and mixed HRV descriptions separately. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Planned comparisons, effects, CIs, important changes and sample planning	Material needed: HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures. This records needed materials; no new research was executed.
17	Unverified	Full text not readStored summary read	N17 · Evidence conditionWas this independently replicated under the same conditions?Required	Distinguish 6-week combined breathing from acute HRV with a different comparator. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report/trial families and the same measures, periods and intervention/controls	Material needed: Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports. This records needed materials; no new research was executed.
18	Unverified	Full text not readStored summary read	N18 · Evidence conditionHow far can results be extended?Required	The parent text says it did not use results from other pranayama or combined yoga and distinguishes pressure/HRV from medication replacement and long-term events. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Combined/standalone, other breathing, surrogates and long-term events	Material needed: Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions. This records needed materials; no new research was executed.
19	Unverified	Full text not readStored summary read	N19 · Evidence conditionWere existing treatment and actual delivery effects verified?Supplementary	Mittal added an intervention while retaining medication and lifestyle care. S01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Existing medication, changes, lifestyle, delivery and exposure at measurement	Material needed: Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWere funding, products, employee authors and COI verified?Required	Preserve Mittal's reported public/academic support and Ghiya's academic-study wording. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific support and evaluation, analysis and publication roles	Material needed: Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence. This records needed materials; no new research was executed.
21	Unverified	Full text not readStored summary read	N21 · Evidence conditionWere harms and their collection verified?Supplementary	Preserve parent caution and original safety text. Null or improved outcomes do not become safety certification. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Harm definitions, arm events, denominators, exposure time, stopping and missingness	Material needed: Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims. This records needed materials; no new research was executed.
22	Unverified	Full text not readStored summary read	N22 · Evidence conditionDoes this answer long-term and vulnerable-group safety?Supplementary	Preserve original caution as historical context and create no new breathing, medication reduction/replacement or treatment instructions. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Long follow-up, vulnerable groups, concurrent exposure and existing treatment	Material needed: Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionHow are existing verdicts and dates preserved?Required	Preserve parent C with 50 points, unrecorded precision, original bilingual texts, 2026-09-07, empty correction/deliberation records and selected grade D/note. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Parent/subclaim original values, both languages, axes, dates and correction history	Material needed: Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionWhich materials were actually read?Required	Production used the complete stored JSON summaries and bibliography. Distinguish summary reading from unread external materials. S01 S02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific stored summaries, external papers, registration, plans and support	Material needed: External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks. This records needed materials; no new research was executed.

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24 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Mittal randomized 91 adults with hypertension continuing medication and lifestyle care; 68 completed. Preserve original 23 withdrawals and 25.3% attrition. Arm analysis denominators for DBP and each HRV measure are unverified. Ghiya has a separate 100-participant acute report; eligibility and medication status are not filled in as the same population.
Ingredient, formulation and route: The study added a combined alternate-nostril breathing program preceded by abdominal breathing to standard care. This is not converted into standalone alternate-nostril, other pranayama or combined-yoga effects. Component contributions, actual delivery, instruction and adherence are unverified.
Dose: Original study identifiers are 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing, 12 minutes daily for 6 weeks. Actual exposure, adherence and discontinuation are unverified. This plan is not turned into personal breathing procedures, medication reduction/replacement or treatment instructions.
Comparator: Combined breathing added to standard management versus standard management alone. Actual medication types, doses, changes, lifestyle care and contact/attention controls are unverified. Ghiya's other-pranayama comparator is a separate acute HRV context.
Measured outcome: The selection is improved DBP or HRV. Preserve original Mittal 6-week DBP P>.05/null and the record that HRV varied by metric and study. Ghiya has an acute between-group HRV null result. Exact measures, units, between-group effects, 95% CIs and denominators are unverified. Null does not become effect 0 or equivalence, and mixed results do not become autonomic normalization.
Duration: Distinguish Mittal 6-week DBP/HRV from Ghiya acute HRV. Exact measurement timing, post-training persistence, harm follow-up, medication changes and long-term clinical events are unverified. Acute results do not become 6-week replication or long-term effects.
Questions outside this scope: Extending null DBP into exact effect 0, equivalence or absence of harm; Extending HRV results varying by metric and study into autonomic normalization; Transferring SBP final values, crude differences, P or ± into DBP/HRV effects, 95% CIs or ITT; Turning a combined adjunct, acute active comparison or shared reports into standalone effects, independent replication or participant totals; Turning an original CTRI identifier or empty registration annotation into verified prospective status or a no-registration determination; Using parent C with 50 points, academic support or caution as a subclaim score or certification of independence, precision or safety; Creating new numbers, grades, breathing procedures, medication reduction/replacement or treatment instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S01 · Mittal G, et al. An Exploratory Randomised Trial to Assess the Effect of Nadi Shodhan Pranayama as an Adjunct Versus Standard Non-pharmacological Management in Hypertensives. Ann Neurosci. 2025. PMID: 40242728. PMCID: PMC11996816. DOI: 10.1177/09727531251318810.

PubMed

Material type: Randomized adjunct-to-standard-management trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: SBP 139.14±12.5 vs 147.79±12.8, P<.01; DBP P>.05
Record level: A 6-week trial added combined breathing to medication and lifestyle care. Preserve DBP P>.05/null and HRV differences by metric. The 91 randomized, 68 completed and original 23 withdrawals/25.3% do not replace measure-specific analysis denominators. Exact DBP/HRV values, units, effects/95% CIs, denominators and models are unverified.
Study overlap and independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.
Funding, product-support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading.

S02 · Ghiya S, et al. Comparison of the effects of Nadi Shodhana Pranayama and Bhramari Pranayama on heart rate variability. J Ayurveda Integr Med. 2023. PMID: 37499590. PMCID: PMC10388195. DOI: 10.1016/j.jaim.2023.100774.

PubMed

Material type: Acute comparison with another pranayama
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Findings recorded in the stored summary: Between-group HRV was null
Record level: Separate 100-participant acute HRV comparison with another pranayama; preserve the original between-group null result. This is not independent 6-week DBP/HRV replication; population, arm denominators, measure-specific effects/CIs, measurement conditions and report-family relationships are unverified.
Study overlap and independent replication: Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
External paper	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Statistical analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.
Funding, product-support and COI material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred.

Report counts versus independent study counts

Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which DBP/HRV claim is selected?

Required materials and conditions: Selected claim, grade and note versus the parent SBP verdict
Conditions for verification: Material for Selected claim, grade and note versus the parent SBP verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Selected claim, grade and note versus the parent SBP verdict with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · What outcomes are DBP and HRV?

Required materials and conditions: Outcome definitions, units, timing, denominators and analyses
Conditions for verification: Material for Outcome definitions, units, timing, denominators and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Outcome definitions, units, timing, denominators and analyses with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · Are the populations the same?

Required materials and conditions: Trial eligibility, age, baseline medication and pressure/HRV
Conditions for verification: Material for Trial eligibility, age, baseline medication and pressure/HRV must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Trial eligibility, age, baseline medication and pressure/HRV with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · What combined program was studied?

Required materials and conditions: Preceding breathing, components, actual delivery and adherence
Conditions for verification: Material for Preceding breathing, components, actual delivery and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Preceding breathing, components, actual delivery and adherence with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · What was each control?

Required materials and conditions: Standard care, active control, contact and existing medication/lifestyle care
Conditions for verification: Material for Standard care, active control, contact and existing medication/lifestyle care must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Standard care, active control, contact and existing medication/lifestyle care with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Are observation periods and measurement windows the same?

Required materials and conditions: Outcome periods, measurement timing and follow-up
Conditions for verification: Material for Outcome periods, measurement timing and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Outcome periods, measurement timing and follow-up with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · Are randomized, completed, withdrawn and analysis populations the same?

Required materials and conditions: Outcome-specific arm denominators, missingness and withdrawal reasons
Conditions for verification: Material for Outcome-specific arm denominators, missingness and withdrawal reasons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Outcome-specific arm denominators, missingness and withdrawal reasons with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · What does null DBP mean?

Required materials and conditions: Arm DBP, between-group effects, CIs, exact P and models
Conditions for verification: Material for Arm DBP, between-group effects, CIs, exact P and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Arm DBP, between-group effects, CIs, exact P and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · How did Mittal HRV vary by measure?

Required materials and conditions: Measure list, units, directions, denominators and between-group estimates
Conditions for verification: Material for Measure list, units, directions, denominators and between-group estimates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Measure list, units, directions, denominators and between-group estimates with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · What was Ghiya's acute HRV result?

Required materials and conditions: Active control, measure-specific estimates, denominators and models
Conditions for verification: Material for Active control, measure-specific estimates, denominators and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Active control, measure-specific estimates, denominators and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · Can parent SBP numbers be transferred?

Required materials and conditions: SBP versus DBP/HRV and final values versus adjusted changes
Conditions for verification: Material for SBP versus DBP/HRV and final values versus adjusted changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects SBP versus DBP/HRV and final values versus adjusted changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · How did DBP/HRV analyses handle missingness and baseline values?

Required materials and conditions: Outcome-specific ITT/PP, adjustment, repeated models and sensitivity
Conditions for verification: Material for Outcome-specific ITT/PP, adjustment, repeated models and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Outcome-specific ITT/PP, adjustment, repeated models and sensitivity with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · Were allocation, blinding and evaluation roles verified?

Required materials and conditions: Allocation, concealment and participant/evaluator/analyst roles
Conditions for verification: Material for Allocation, concealment and participant/evaluator/analyst roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Allocation, concealment and participant/evaluator/analyst roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Were pressure/HRV measurement conditions and quality verified?

Required materials and conditions: Devices, resting conditions, repeats and signal quality
Conditions for verification: Material for Devices, resting conditions, repeats and signal quality must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Devices, resting conditions, repeats and signal quality with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · Does registration wording establish prospective endpoints?

Required materials and conditions: Registration, protocol, SAP, DBP/HRV hierarchy and changes
Conditions for verification: Material for Registration, protocol, SAP, DBP/HRV hierarchy and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Registration, protocol, SAP, DBP/HRV hierarchy and changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · Were precision and clinical meaning across measures verified?

Required materials and conditions: Planned comparisons, effects, CIs, important changes and sample planning
Conditions for verification: Material for Planned comparisons, effects, CIs, important changes and sample planning must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Planned comparisons, effects, CIs, important changes and sample planning with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · Was this independently replicated under the same conditions?

Required materials and conditions: Report/trial families and the same measures, periods and intervention/controls
Conditions for verification: Material for Report/trial families and the same measures, periods and intervention/controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report/trial families and the same measures, periods and intervention/controls with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · How far can results be extended?

Required materials and conditions: Combined/standalone, other breathing, surrogates and long-term events
Conditions for verification: Material for Combined/standalone, other breathing, surrogates and long-term events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Combined/standalone, other breathing, surrogates and long-term events with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · Were existing treatment and actual delivery effects verified?

Required materials and conditions: Existing medication, changes, lifestyle, delivery and exposure at measurement
Conditions for verification: Material for Existing medication, changes, lifestyle, delivery and exposure at measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Existing medication, changes, lifestyle, delivery and exposure at measurement with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · Were funding, products, employee authors and COI verified?

Required materials and conditions: Report-specific support and evaluation, analysis and publication roles
Conditions for verification: Material for Report-specific support and evaluation, analysis and publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific support and evaluation, analysis and publication roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · Were harms and their collection verified?

Required materials and conditions: Harm definitions, arm events, denominators, exposure time, stopping and missingness
Conditions for verification: Material for Harm definitions, arm events, denominators, exposure time, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Harm definitions, arm events, denominators, exposure time, stopping and missingness with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Does this answer long-term and vulnerable-group safety?

Required materials and conditions: Long follow-up, vulnerable groups, concurrent exposure and existing treatment
Conditions for verification: Material for Long follow-up, vulnerable groups, concurrent exposure and existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Long follow-up, vulnerable groups, concurrent exposure and existing treatment with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · How are existing verdicts and dates preserved?

Required materials and conditions: Parent/subclaim original values, both languages, axes, dates and correction history
Conditions for verification: Material for Parent/subclaim original values, both languages, axes, dates and correction history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Parent/subclaim original values, both languages, axes, dates and correction history with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · Which materials were actually read?

Required materials and conditions: Report-specific stored summaries, external papers, registration, plans and support
Conditions for verification: Material for Report-specific stored summaries, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Why this condition is needed: This condition connects Report-specific stored summaries, external papers, registration, plans and support with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete.
Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete.
Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.
Review incomplete: User review pending.
Not reported: Not reported within the stored material actually read; not extended to the entire primary paper.
Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state.
Not applicable: Not used as a substitute for an evidence gap.
Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.
Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade.

Change history

2026-10-18 · Public page/material version 1.0

Public pages and materials were prepared from the existing 24 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which DBP/HRV claim is selected?

Current findings: The selection is improved DBP or HRV. Preserve original grade D and the note that DBP was null and HRV varied by metric and study. Parent C with 50 points concerns 6-week SBP.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes.
Required materials and conditions: Selected claim, grade and note versus the parent SBP verdict
Materials to obtain first: The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes.
Further research: Material needed: The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Selected claim, grade and note versus the parent SBP verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Selected claim, grade and note versus the parent SBP verdict with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N02 · What outcomes are DBP and HRV?

Current findings: Mittal covers 6-week SBP/DBP and HRV; Ghiya covers acute HRV.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect.
Required materials and conditions: Outcome definitions, units, timing, denominators and analyses
Materials to obtain first: Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect.
Further research: Material needed: Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Outcome definitions, units, timing, denominators and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Outcome definitions, units, timing, denominators and analyses with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N03 · Are the populations the same?

Current findings: Mittal is a standard-care adjunct trial in adults with hypertension on medication, with 91 randomized and 68 completed. Ghiya has an original 100 participants.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population.
Required materials and conditions: Trial eligibility, age, baseline medication and pressure/HRV
Materials to obtain first: Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population.
Further research: Material needed: Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Trial eligibility, age, baseline medication and pressure/HRV must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Trial eligibility, age, baseline medication and pressure/HRV with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N04 · What combined program was studied?

Current findings: Mittal added 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing daily as a combined intervention. These identify the study and are not breathing instructions.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone.
Required materials and conditions: Preceding breathing, components, actual delivery and adherence
Materials to obtain first: Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone.
Further research: Material needed: Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Preceding breathing, components, actual delivery and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Preceding breathing, components, actual delivery and adherence with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N05 · What was each control?

Current findings: Mittal compares an addition to standard care retaining medication and lifestyle management; Ghiya is an acute comparison with another pranayama.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control.
Required materials and conditions: Standard care, active control, contact and existing medication/lifestyle care
Materials to obtain first: Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control.
Further research: Material needed: Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Standard care, active control, contact and existing medication/lifestyle care must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Standard care, active control, contact and existing medication/lifestyle care with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N06 · Are observation periods and measurement windows the same?

Current findings: Mittal 6-week and Ghiya acute HRV observations have different windows.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement.
Required materials and conditions: Outcome periods, measurement timing and follow-up
Materials to obtain first: Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement.
Further research: Material needed: Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Outcome periods, measurement timing and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Outcome periods, measurement timing and follow-up with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N07 · Are randomized, completed, withdrawn and analysis populations the same?

Current findings: Preserve original 91 randomized, 68 completed and parent-record 23 withdrawals/25.3% attrition.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators.
Required materials and conditions: Outcome-specific arm denominators, missingness and withdrawal reasons
Materials to obtain first: Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators.
Further research: Material needed: Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Outcome-specific arm denominators, missingness and withdrawal reasons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Outcome-specific arm denominators, missingness and withdrawal reasons with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N08 · What does null DBP mean?

Current findings: Preserve Mittal DBP P>.05 and the selected note's null DBP result.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence.
Required materials and conditions: Arm DBP, between-group effects, CIs, exact P and models
Materials to obtain first: Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence.
Further research: Material needed: Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm DBP, between-group effects, CIs, exact P and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm DBP, between-group effects, CIs, exact P and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N09 · How did Mittal HRV vary by measure?

Current findings: Original explanations and the selected note record HRV varying by metric and study.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV.
Required materials and conditions: Measure list, units, directions, denominators and between-group estimates
Materials to obtain first: Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV.
Further research: Material needed: Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Measure list, units, directions, denominators and between-group estimates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Measure list, units, directions, denominators and between-group estimates with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N10 · What was Ghiya's acute HRV result?

Current findings: Preserve Ghiya 100 participants, acute comparison with another pranayama and between-group null HRV.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect.
Required materials and conditions: Active control, measure-specific estimates, denominators and models
Materials to obtain first: Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect.
Further research: Material needed: Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Active control, measure-specific estimates, denominators and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Active control, measure-specific estimates, denominators and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S02

N11 · Can parent SBP numbers be transferred?

Current findings: SBP 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and existing crude difference -8.65 mmHg are parent SBP context.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs.
Required materials and conditions: SBP versus DBP/HRV and final values versus adjusted changes
Materials to obtain first: Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs.
Further research: Material needed: Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for SBP versus DBP/HRV and final values versus adjusted changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects SBP versus DBP/HRV and final values versus adjusted changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N12 · How did DBP/HRV analyses handle missingness and baseline values?

Current findings: The parent record retains complete-case analysis and unverified adjusted between-group effects/CIs.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified.
Required materials and conditions: Outcome-specific ITT/PP, adjustment, repeated models and sensitivity
Materials to obtain first: DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified.
Further research: Material needed: DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Outcome-specific ITT/PP, adjustment, repeated models and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Outcome-specific ITT/PP, adjustment, repeated models and sensitivity with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N13 · Were allocation, blinding and evaluation roles verified?

Current findings: Preserve original designs described as a Mittal randomized adjunct trial and Ghiya acute comparison.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial.
Required materials and conditions: Allocation, concealment and participant/evaluator/analyst roles
Materials to obtain first: Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial.
Further research: Material needed: Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, concealment and participant/evaluator/analyst roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, concealment and participant/evaluator/analyst roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N14 · Were pressure/HRV measurement conditions and quality verified?

Current findings: Each report records pressure or HRV outcomes.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions.
Required materials and conditions: Devices, resting conditions, repeats and signal quality
Materials to obtain first: Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions.
Further research: Material needed: Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Devices, resting conditions, repeats and signal quality must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Devices, resting conditions, repeats and signal quality with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N15 · Does registration wording establish prospective endpoints?

Current findings: Mittal's original registration wording is CTRI/2023/11/059625; Ghiya says unverified. The parent record retains unverified formal prospective endpoints.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered.
Required materials and conditions: Registration, protocol, SAP, DBP/HRV hierarchy and changes
Materials to obtain first: Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered.
Further research: Material needed: Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Registration, protocol, SAP, DBP/HRV hierarchy and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Registration, protocol, SAP, DBP/HRV hierarchy and changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N16 · Were precision and clinical meaning across measures verified?

Current findings: Preserve null DBP and mixed HRV descriptions separately.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures.
Required materials and conditions: Planned comparisons, effects, CIs, important changes and sample planning
Materials to obtain first: HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures.
Further research: Material needed: HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Planned comparisons, effects, CIs, important changes and sample planning must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Planned comparisons, effects, CIs, important changes and sample planning with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N17 · Was this independently replicated under the same conditions?

Current findings: Distinguish 6-week combined breathing from acute HRV with a different comparator.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports.
Required materials and conditions: Report/trial families and the same measures, periods and intervention/controls
Materials to obtain first: Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports.
Further research: Material needed: Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report/trial families and the same measures, periods and intervention/controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report/trial families and the same measures, periods and intervention/controls with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N18 · How far can results be extended?

Current findings: The parent text says it did not use results from other pranayama or combined yoga and distinguishes pressure/HRV from medication replacement and long-term events.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions.
Required materials and conditions: Combined/standalone, other breathing, surrogates and long-term events
Materials to obtain first: Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions.
Further research: Material needed: Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Combined/standalone, other breathing, surrogates and long-term events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Combined/standalone, other breathing, surrogates and long-term events with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N19 · Were existing treatment and actual delivery effects verified?

Current findings: Mittal added an intervention while retaining medication and lifestyle care.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change.
Required materials and conditions: Existing medication, changes, lifestyle, delivery and exposure at measurement
Materials to obtain first: Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change.
Further research: Material needed: Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Existing medication, changes, lifestyle, delivery and exposure at measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Existing medication, changes, lifestyle, delivery and exposure at measurement with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01

N20 · Were funding, products, employee authors and COI verified?

Current findings: Preserve Mittal's reported public/academic support and Ghiya's academic-study wording.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence.
Required materials and conditions: Report-specific support and evaluation, analysis and publication roles
Materials to obtain first: Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence.
Further research: Material needed: Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific support and evaluation, analysis and publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific support and evaluation, analysis and publication roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N21 · Were harms and their collection verified?

Current findings: Preserve parent caution and original safety text. Null or improved outcomes do not become safety certification.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims.
Required materials and conditions: Harm definitions, arm events, denominators, exposure time, stopping and missingness
Materials to obtain first: Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims.
Further research: Material needed: Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Harm definitions, arm events, denominators, exposure time, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Harm definitions, arm events, denominators, exposure time, stopping and missingness with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N22 · Does this answer long-term and vulnerable-group safety?

Current findings: Preserve original caution as historical context and create no new breathing, medication reduction/replacement or treatment instructions.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples.
Required materials and conditions: Long follow-up, vulnerable groups, concurrent exposure and existing treatment
Materials to obtain first: Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples.
Further research: Material needed: Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Long follow-up, vulnerable groups, concurrent exposure and existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Long follow-up, vulnerable groups, concurrent exposure and existing treatment with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N23 · How are existing verdicts and dates preserved?

Current findings: Preserve parent C with 50 points, unrecorded precision, original bilingual texts, 2026-09-07, empty correction/deliberation records and selected grade D/note.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates.
Required materials and conditions: Parent/subclaim original values, both languages, axes, dates and correction history
Materials to obtain first: Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates.
Further research: Material needed: Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Parent/subclaim original values, both languages, axes, dates and correction history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Parent/subclaim original values, both languages, axes, dates and correction history with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02

N24 · Which materials were actually read?

Current findings: Production used the complete stored JSON summaries and bibliography. Distinguish summary reading from unread external materials.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks.
Required materials and conditions: Report-specific stored summaries, external papers, registration, plans and support
Materials to obtain first: External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks.
Further research: Material needed: External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific stored summaries, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific stored summaries, external papers, registration, plans and support with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.
Application exceptions: Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources S01 S02