{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3001-s1", "verdict_number": "3001", "title": "Combined breathing added to standard care × DBP and HRV: evidence checklist", "view_version": "1.0", "view_created_date": "2026-10-18", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Mittal randomized 91 adults with hypertension continuing medication and lifestyle care; 68 completed. Preserve original 23 withdrawals and 25.3% attrition. Arm analysis denominators for DBP and each HRV measure are unverified. Ghiya has a separate 100-participant acute report; eligibility and medication status are not filled in as the same population.", "intervention": "The study added a combined alternate-nostril breathing program preceded by abdominal breathing to standard care. This is not converted into standalone alternate-nostril, other pranayama or combined-yoga effects. Component contributions, actual delivery, instruction and adherence are unverified.", "dose": "Original study identifiers are 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing, 12 minutes daily for 6 weeks. Actual exposure, adherence and discontinuation are unverified. This plan is not turned into personal breathing procedures, medication reduction/replacement or treatment instructions.", "comparator": "Combined breathing added to standard management versus standard management alone. Actual medication types, doses, changes, lifestyle care and contact/attention controls are unverified. Ghiya's other-pranayama comparator is a separate acute HRV context.", "endpoint": "The selection is improved DBP or HRV. Preserve original Mittal 6-week DBP P>.05/null and the record that HRV varied by metric and study. Ghiya has an acute between-group HRV null result. Exact measures, units, between-group effects, 95% CIs and denominators are unverified. Null does not become effect 0 or equivalence, and mixed results do not become autonomic normalization.", "duration": "Distinguish Mittal 6-week DBP/HRV from Ghiya acute HRV. Exact measurement timing, post-training persistence, harm follow-up, medication changes and long-term clinical events are unverified. Acute results do not become 6-week replication or long-term effects.", "excluded_extensions": [ "Extending null DBP into exact effect 0, equivalence or absence of harm", "Extending HRV results varying by metric and study into autonomic normalization", "Transferring SBP final values, crude differences, P or ± into DBP/HRV effects, 95% CIs or ITT", "Turning a combined adjunct, acute active comparison or shared reports into standalone effects, independent replication or participant totals", "Turning an original CTRI identifier or empty registration annotation into verified prospective status or a no-registration determination", "Using parent C with 50 points, academic support or caution as a subclaim score or certification of independence, precision or safety", "Creating new numbers, grades, breathing procedures, medication reduction/replacement or treatment instructions" ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which DBP/HRV claim is selected?", "needed": "Selected claim, grade and note versus the parent SBP verdict", "role": "Required", "role_reason": "This condition connects Selected claim, grade and note versus the parent SBP verdict with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Selected claim, grade and note versus the parent SBP verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The selection is improved DBP or HRV. Preserve original grade D and the note that DBP was null and HRV varied by metric and study. Parent C with 50 points concerns 6-week SBP.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The selected subclaim has no score, status or axes fields. Do not fill them with parent scores or axes." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "What outcomes are DBP and HRV?", "needed": "Outcome definitions, units, timing, denominators and analyses", "role": "Required", "role_reason": "This condition connects Outcome definitions, units, timing, denominators and analyses with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Outcome definitions, units, timing, denominators and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal covers 6-week SBP/DBP and HRV; Ghiya covers acute HRV.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact HRV measures, units and models and original DBP tables are unverified. Do not combine DBP and HRV into one effect." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Are the populations the same?", "needed": "Trial eligibility, age, baseline medication and pressure/HRV", "role": "Required", "role_reason": "This condition connects Trial eligibility, age, baseline medication and pressure/HRV with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Trial eligibility, age, baseline medication and pressure/HRV must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal is a standard-care adjunct trial in adults with hypertension on medication, with 91 randomized and 68 completed. Ghiya has an original 100 participants.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Ghiya eligibility/medication status and both trials' age and baseline DBP/HRV are unverified. Do not fill in the same hypertension population." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "What combined program was studied?", "needed": "Preceding breathing, components, actual delivery and adherence", "role": "Required", "role_reason": "This condition connects Preceding breathing, components, actual delivery and adherence with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Preceding breathing, components, actual delivery and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal added 2 minutes of abdominal breathing followed by 10 minutes of alternate-nostril breathing daily as a combined intervention. These identify the study and are not breathing instructions.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual intensity, adherence and incremental component contributions are unverified. Do not attribute effects to alternate-nostril breathing alone." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What was each control?", "needed": "Standard care, active control, contact and existing medication/lifestyle care", "role": "Required", "role_reason": "This condition connects Standard care, active control, contact and existing medication/lifestyle care with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Standard care, active control, contact and existing medication/lifestyle care must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal compares an addition to standard care retaining medication and lifestyle management; Ghiya is an acute comparison with another pranayama.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm contact, co-management and delivery details are unverified. Do not turn Ghiya's control into a 6-week standard-care control." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are observation periods and measurement windows the same?", "needed": "Outcome periods, measurement timing and follow-up", "role": "Required", "role_reason": "This condition connects Outcome periods, measurement timing and follow-up with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Outcome periods, measurement timing and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal 6-week and Ghiya acute HRV observations have different windows.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Detailed test timing is unverified. Do not count acute HRV as independent replication of 6-week pressure or long-term autonomic improvement." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Are randomized, completed, withdrawn and analysis populations the same?", "needed": "Outcome-specific arm denominators, missingness and withdrawal reasons", "role": "Required", "role_reason": "This condition connects Outcome-specific arm denominators, missingness and withdrawal reasons with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Outcome-specific arm denominators, missingness and withdrawal reasons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original 91 randomized, 68 completed and parent-record 23 withdrawals/25.3% attrition.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm denominators for DBP/each HRV measure, withdrawal reasons and outcomes for all randomized participants are unverified. Calculate no new attrition rates or denominators." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What does null DBP mean?", "needed": "Arm DBP, between-group effects, CIs, exact P and models", "role": "Required", "role_reason": "This condition connects Arm DBP, between-group effects, CIs, exact P and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Arm DBP, between-group effects, CIs, exact P and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Mittal DBP P>.05 and the selected note's null DBP result.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm values, effects, CIs, exact P and models are unverified. Null does not mean exact effect 0 or equivalence." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "How did Mittal HRV vary by measure?", "needed": "Measure list, units, directions, denominators and between-group estimates", "role": "Required", "role_reason": "This condition connects Measure list, units, directions, denominators and between-group estimates with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Measure list, units, directions, denominators and between-group estimates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Original explanations and the selected note record HRV varying by metric and study.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact measures, values, effects, CIs, P and measurement conditions are unverified. Do not extend this to normalization of all HRV." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "What was Ghiya's acute HRV result?", "needed": "Active control, measure-specific estimates, denominators and models", "role": "Required", "role_reason": "This condition connects Active control, measure-specific estimates, denominators and models with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Active control, measure-specific estimates, denominators and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Ghiya 100 participants, acute comparison with another pranayama and between-group null HRV.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Measures, units, arm denominators, baseline/final values, CIs, P and models are unverified. Do not transfer this into a 6-week HRV effect." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Can parent SBP numbers be transferred?", "needed": "SBP versus DBP/HRV and final values versus adjusted changes", "role": "Required", "role_reason": "This condition connects SBP versus DBP/HRV and final values versus adjusted changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for SBP versus DBP/HRV and final values versus adjusted changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "SBP 139.14±12.5 versus 147.79±12.8 mmHg, P<.01 and existing crude difference -8.65 mmHg are parent SBP context.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Do not turn SBP final values or existing arithmetic into DBP/HRV effects or adjusted changes. Calculate no new differences or CIs." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "How did DBP/HRV analyses handle missingness and baseline values?", "needed": "Outcome-specific ITT/PP, adjustment, repeated models and sensitivity", "role": "Required", "role_reason": "This condition connects Outcome-specific ITT/PP, adjustment, repeated models and sensitivity with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Outcome-specific ITT/PP, adjustment, repeated models and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The parent record retains complete-case analysis and unverified adjusted between-group effects/CIs.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "DBP/each HRV measure's ITT/PP, missing-data handling, baseline adjustment, repeated models and sensitivity analyses are unverified." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Were allocation, blinding and evaluation roles verified?", "needed": "Allocation, concealment and participant/evaluator/analyst roles", "role": "Required", "role_reason": "This condition connects Allocation, concealment and participant/evaluator/analyst roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Allocation, concealment and participant/evaluator/analyst roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original designs described as a Mittal randomized adjunct trial and Ghiya acute comparison.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Allocation, concealment, evaluation/analysis roles and expectancy control are unverified. Do not fill in Ghiya as a newly established randomized trial." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Were pressure/HRV measurement conditions and quality verified?", "needed": "Devices, resting conditions, repeats and signal quality", "role": "Required", "role_reason": "This condition connects Devices, resting conditions, repeats and signal quality with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Devices, resting conditions, repeats and signal quality must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Each report records pressure or HRV outcomes.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Devices, rest, measurement counts, HRV recording length, breathing conditions and quality/exclusion rules are unverified. Do not merge different measurement conditions." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Does registration wording establish prospective endpoints?", "needed": "Registration, protocol, SAP, DBP/HRV hierarchy and changes", "role": "Required", "role_reason": "This condition connects Registration, protocol, SAP, DBP/HRV hierarchy and changes with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Registration, protocol, SAP, DBP/HRV hierarchy and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal's original registration wording is CTRI/2023/11/059625; Ghiya says unverified. The parent record retains unverified formal prospective endpoints.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration, protocols, SAPs, measure hierarchy, multiplicity and changes are unread. An identifier alone does not verify prospective status; unverified does not mean unregistered." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Were precision and clinical meaning across measures verified?", "needed": "Planned comparisons, effects, CIs, important changes and sample planning", "role": "Required", "role_reason": "This condition connects Planned comparisons, effects, CIs, important changes and sample planning with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Planned comparisons, effects, CIs, important changes and sample planning must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve null DBP and mixed HRV descriptions separately.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "HRV multiple comparisons, planned contrasts, measure-specific effects/CIs, clinical importance thresholds and sample planning are unverified. Create no new effects, CIs or example measures." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Was this independently replicated under the same conditions?", "needed": "Report/trial families and the same measures, periods and intervention/controls", "role": "Required", "role_reason": "This condition connects Report/trial families and the same measures, periods and intervention/controls with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Report/trial families and the same measures, periods and intervention/controls must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish 6-week combined breathing from acute HRV with a different comparator.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Independent confirmation under the same DBP/HRV conditions and unique-trial/participant totals are unconfirmed. Do not simply add the two reports." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "How far can results be extended?", "needed": "Combined/standalone, other breathing, surrogates and long-term events", "role": "Required", "role_reason": "This condition connects Combined/standalone, other breathing, surrogates and long-term events with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Combined/standalone, other breathing, surrogates and long-term events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The parent text says it did not use results from other pranayama or combined yoga and distinguishes pressure/HRV from medication replacement and long-term events.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct evidence for extending DBP/HRV into autonomic normalization, medication reduction/replacement or clinical-event prevention is unverified. Create no new breathing or treatment instructions." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Were existing treatment and actual delivery effects verified?", "needed": "Existing medication, changes, lifestyle, delivery and exposure at measurement", "role": "Supplementary", "role_reason": "This condition connects Existing medication, changes, lifestyle, delivery and exposure at measurement with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Existing medication, changes, lifestyle, delivery and exposure at measurement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Mittal added an intervention while retaining medication and lifestyle care.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Outcome-specific medication/changes, lifestyle factors, actual delivery and measurement-condition effects are unverified. Do not newly establish causes of change." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Were funding, products, employee authors and COI verified?", "needed": "Report-specific support and evaluation, analysis and publication roles", "role": "Required", "role_reason": "This condition connects Report-specific support and evaluation, analysis and publication roles with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Report-specific support and evaluation, analysis and publication roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Mittal's reported public/academic support and Ghiya's academic-study wording.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Product/training support, employee authors, COI and role/control details are unverified. Academic wording does not verify overall independence." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Were harms and their collection verified?", "needed": "Harm definitions, arm events, denominators, exposure time, stopping and missingness", "role": "Supplementary", "role_reason": "This condition connects Harm definitions, arm events, denominators, exposure time, stopping and missingness with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Harm definitions, arm events, denominators, exposure time, stopping and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent caution and original safety text. Null or improved outcomes do not become safety certification.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm harms, collection procedures, stopping, denominators and missing data are unverified. Create no new event rates or safety claims." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Does this answer long-term and vulnerable-group safety?", "needed": "Long follow-up, vulnerable groups, concurrent exposure and existing treatment", "role": "Supplementary", "role_reason": "This condition connects Long follow-up, vulnerable groups, concurrent exposure and existing treatment with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Long follow-up, vulnerable groups, concurrent exposure and existing treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original caution as historical context and create no new breathing, medication reduction/replacement or treatment instructions.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Long-term, vulnerable-group and existing-medication/other-cause harm data are unverified. Do not extend safety from limited samples." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "How are existing verdicts and dates preserved?", "needed": "Parent/subclaim original values, both languages, axes, dates and correction history", "role": "Required", "role_reason": "This condition connects Parent/subclaim original values, both languages, axes, dates and correction history with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Parent/subclaim original values, both languages, axes, dates and correction history must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent C with 50 points, unrecorded precision, original bilingual texts, 2026-09-07, empty correction/deliberation records and selected grade D/note.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Do not inherit parent scores, axes or historical cross-checks as subclaim values or current review/certification. Production dates do not become completed-review dates." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Which materials were actually read?", "needed": "Report-specific stored summaries, external papers, registration, plans and support", "role": "Required", "role_reason": "This condition connects Report-specific stored summaries, external papers, registration, plans and support with selected DBP and HRV, the combined adjunct, measures, timing, analysis denominators, attrition, directness and harm boundaries.", "application_exception": "Preserve selected D and the note that DBP was null and HRV varied by metric and study. Distinguish absent subclaim score/status/axes from parent C with 50 points. Other measures, times, controls and existing numbers do not become new effects, independent replication or totals. Create no new grades, safety certification or breathing, medication or treatment instructions.", "criterion": "Material for Report-specific stored summaries, external papers, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Production used the complete stored JSON summaries and bibliography. Distinguish summary reading from unread external materials.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External papers, registration, protocols, SAPs and support materials are unread and access was not attempted. URLs and historical verification wording do not become current reading or link checks." } ], "reports": [ { "report_id": "S01", "title": "Mittal G, et al. An Exploratory Randomised Trial to Assess the Effect of Nadi Shodhan Pranayama as an Adjunct Versus Standard Non-pharmacological Management in Hypertensives. Ann Neurosci. 2025. PMID: 40242728. PMCID: PMC11996816. DOI: 10.1177/09727531251318810.", "url": "https://pubmed.ncbi.nlm.nih.gov/40242728/", "report_type": "Randomized adjunct-to-standard-management trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S01; unique counts and independent replication unverified", "independent_replication": "Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals.", "observed_result": "SBP 139.14±12.5 vs 147.79±12.8, P<.01; DBP P>.05", "result_level": "A 6-week trial added combined breathing to medication and lifestyle care. Preserve DBP P>.05/null and HRV differences by metric. The 91 randomized, 68 completed and original 23 withdrawals/25.3% do not replace measure-specific analysis denominators. Exact DBP/HRV values, units, effects/95% CIs, denominators and models are unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 40242728, PMCID PMC11996816 and DOI 10.1177/09727531251318810. The original registration wording is CTRI/2023/11/059625; this case has no recorded separate registration annotation. Do not turn CTRI into NCT or infer a new registration URL, prospective status or original-text reading." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/40242728/" } ] }, { "report_id": "S02", "title": "Ghiya S, et al. Comparison of the effects of Nadi Shodhana Pranayama and Bhramari Pranayama on heart rate variability. J Ayurveda Integr Med. 2023. PMID: 37499590. PMCID: PMC10388195. DOI: 10.1016/j.jaim.2023.100774.", "url": "https://pubmed.ncbi.nlm.nih.gov/37499590/", "report_type": "Acute comparison with another pranayama", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S02; unique counts and independent replication unverified", "independent_replication": "Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals.", "observed_result": "Between-group HRV was null", "result_level": "Separate 100-participant acute HRV comparison with another pranayama; preserve the original between-group null result. This is not independent 6-week DBP/HRV replication; population, arm denominators, measure-specific effects/CIs, measurement conditions and report-family relationships are unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 37499590, PMCID PMC10388195 and DOI 10.1016/j.jaim.2023.100774. The original evidence registration field says unverified; no separate registration annotation is recorded for this case. This does not establish no registration; no new identifier, URL, prospective status or original-text reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/37499590/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.", "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.", "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.", "Review incomplete": "User review pending.", "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.", "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.", "Not applicable": "Not used as a substitute for an evidence gap.", "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.", "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Mittal SBP, DBP and HRV are measures from one stored report; Ghiya compares acute HRV with another pranayama. Independent confirmation with the same measures, timing, intervention/controls and unique-trial/participant totals are unverified. Repeated measures, randomized/completed/withdrawn participants and shared questions are not counted as new independent trials or participant totals." }, "history": [ { "date": "2026-10-18", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public pages and materials were prepared from the existing 24 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-18" }