Chemically characterized raw garlic equivalent to about 4 g, six days per week × Reduction of LDL-C in adults with moderate hypercholesterolemia

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Met	Full text not readStored summary read	N01 · Evidence conditionWhich raw-garlic LDL-C question does this table link to the original claim?Required	The original outcome is LDL-C reduction in adults with moderate hypercholesterolemia. California Early raw garlic was supplied in sandwiches at about one average 4-g clove, 6 days weekly for 6 months, against matched garlic-free sandwich placebo. The endpoint is 6-month LDL-C change from baseline. Powder, AGE and oil provide formulation-specific auxiliary context. S1 S2	The current Korean claim, Korean/English descriptors and scope note are linked to the final raw-garlic main-question selection. This status verifies question identity and scope, without establishing raw-garlic efficacy.	The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary	Material needed: The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWho is covered by the LDL-C range, age range and absence of lipid-lowering medicine?Required	The main population is adults aged 30~65 with LDL-C 130~190 mg/dL who were not using lipid-lowering medicine. The total of 192 is the allocation denominator across all 4 arms. The oil report records only 25 completers; direct identity with the raw-garlic population is unverified. S1 S2	Original raw-garlic population conditions are specific, but recruitment/eligibility, baseline tables, representativeness and arm-specific denominators are unavailable in the retained summary.	The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables	Material needed: The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWere the California Early raw-garlic food formulation and chemical specifications verified?Required	The original formulation is California Early raw garlic from fresh Allium sativum L. cloves supplied in sandwiches as food. The Korean/English ingredient descriptions state chemically characterized material equivalent to about 4 g; product descriptions prohibit interchange with other garlic formulations. S1	Raw-garlic food/material identity is stated. Chemical-characterization wording is retained, but the actual analytical table and batch/specifications were not newly acquired.	Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications	Material needed: Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionIs the comparator a matched garlic-free sandwich placebo?Required	The original raw-garlic comparator is a matched garlic-free sandwich placebo. Powder, AGE and placebo changes are also reported in the same 4-arm trial, but actual placebo/treatment details for the other formulations remain separately unverified. S1	The original placebo contract for selected raw garlic was verified. Detailed food composition/energy, provision and treatments in other groups were not verified.	The original food-placebo description and methods for food provision, energy/constituents and control treatment	Material needed: The original food-placebo description and methods for food provision, energy/constituents and control treatment. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionAre the nominal about 4-g amount on 6 days weekly and actual intake/adherence distinct?Required	The nominal intake is about one average 4-g clove on 6 days weekly. Actual batch amount, intake/adherence records and changes by group are not specified in the retained summary. S1	Nominal amount and frequency link to the original description, but actual-exposure, adherence and departure conditions could not be verified.	The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records	Material needed: The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records. This records needed materials; no new research was executed.
6	Met	Full text not readStored summary read	N06 · Evidence conditionAre 6-month treatment, monthly measurements and the final 6-month endpoint distinct?Required	Original descriptors separately record 6 months of treatment with monthly lipid measurements and 6-month LDL-C change from baseline. The selected result is the final 6-month endpoint; monthly observations are not independent trials. S1	Stated treatment duration, measurement frequency and the selected time point are distinguished as originally recorded. Met concerns temporal attribution, without establishing longer-term persistence.	6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions	Material needed: 6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionAre 4-arm reporting, bibliographies and the total 192 kept free of duplicate counting?Required	The main Gardner report is a 4-arm randomized parallel trial with 192 allocated in total. The first evidence entry, first bibliography and Korean/English descriptions are linked as restatements of the same report. The Berthold 1998 oil report/bibliography is separate auxiliary context from another formulation. S1 S2	The 2 local reports and 2 bibliographies, and identity within each pair, are linked. Original registrations, related reports, recruitment identity and total independent-trial/participant counts were not newly verified.	Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links	Material needed: Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links. This records needed materials; no new research was executed.
8	Met	Full text not readStored summary read	N08 · Evidence conditionAre the local summaries actually read distinguished from external material remaining unread?Required	The entire current 3058 retained summary and byte-identical snapshot were read. Retained summaries/bibliographies for both reports and exact original locations, data types and source-identity checks were linked. PubMed, DOI, JAMA, NCT and supplements were not accessed or read; identity/source-identity checks for 5 method HTML files was reused. S1 S2	Actual current local-summary reading and external non-reading are separated by material. A link does not establish abstract/full-text access or acquisition.	Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report	Material needed: Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report. This records needed materials; no new research was executed.
9	Met	Full text not readStored summary read	N09 · Evidence conditionWhat are the verdict date, correction history, current review date and evidence-date scope?Required	The original verdict date is 2026-09-08. The 2026-09-14 English evidence-table placeholder correction is a historical event retaining grade D, without new research/reassessment. Current Korean/English wording, synthesis and generic evidence statements are preserved as originally stored. The current date denotes actual local review. S1 S2	Historical review/correction dates are distinct from actual current reading and search scope. Dates were not used as proof of a new comprehensive literature search or full-text access.	Original verdict date, corrections, Korean/English and synthesis text, and actual current review time	Material needed: Original verdict date, corrections, Korean/English and synthesis text, and actual current review time. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionWhat is verified about NIH/NCCAM support, product donation and oil-report funding?Supplementary; required for an independence claim	NIH/NCCAM support and product donation are recorded for the main report. The oil report identifies a German academic institution, with funding details unverified. Original axis I2 and the original rationale's independent-funding assessment remain historical values. S1 S2	Original support levels are separated by report, but complete COI, provision contracts/involvement, author employment/patents and institutional links were not read in this preparation.	Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material	Material needed: Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionWhat actual 4-arm parallel randomized design does the main trial have?Required	The original main-trial design is a 4-arm randomized parallel trial. The original central explanation describes separate analyses of raw garlic, Garlicin powder and Kyolic AGE. Auxiliary oil is a different randomized, double-blind, placebo-controlled crossover design. S1 S2	Design names and the 4-arm composition are linked to the original record, but randomization/allocation and detailed original methods remain unverified. Parallel and crossover trials were not merged into one design.	The original 4-arm randomized parallel design, arm composition, allocation methods and methods section	Material needed: The original 4-arm randomized parallel design, arm composition, allocation methods and methods section. This records needed materials; no new research was executed.
12	Unverified	Full text not readStored summary read	N12 · Evidence conditionWere allocation concealment, baseline balance and actual blinding implementation verified?Required	The retained summary identifies the main trial as randomized with 4 arms, but provides no random-sequence method, allocation concealment, baseline table by group, food/product blinding or assessor-handling details. S1	The randomized label alone cannot establish allocation protection, balance or blinding. This is an information gap within current local reading.	Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material	Material needed: Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionWhat changes in diet, concomitant medicine and rescue treatment occurred by group?Required	Participants were not using lipid-lowering medicine at baseline, and the comparison used a matched sandwich placebo. Diet, medication/rescue treatment and lifestyle changes during 6 months of follow-up, and their analytical treatment by group, are not specified in the retained summary. S1	Baseline and planned comparison content is verified, but actual accompanying changes during follow-up and differences by group remain unverified.	Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group	Material needed: Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionWere LDL-C methods, laboratory conditions and measurement procedures by group verified?Required	The endpoint is LDL-C in mg/dL, with monthly lipid measurements during 6 months of treatment. LDL testing/calculation methods, blood-sampling/laboratory standardization and assessor-blinding details are unavailable. S1	Endpoint, units and measurement frequency are linked, but actual measurement conditions and procedures by group could not be verified.	LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material	Material needed: LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionAre 6-month LDL-C, other lipid endpoints and prespecified outcome hierarchy distinct?Required	The original reader answer and central explanation describe LDL-C as the primary (1st) endpoint; the descriptors specify 6-month change from baseline. The reasons distinguish total cholesterol, TG and HDL from LDL results. The bibliography contains an NCT identifier, but original plans were not read in this preparation. S1	The retained principal LDL endpoint/time point and separation from other lipids were verified. Actual comparison with prespecified registry endpoints, times and analyses remains unverified.	The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables	Material needed: The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables. This records needed materials; no new research was executed.
16	Met	Full text not readStored summary read	N16 · Evidence conditionWhat changes do +0.4, +3.2, +0.2 and −3.9 represent in the four groups?Required	Original 6-month changes are raw garlic +0.4, powder +3.2, AGE +0.2 and placebo −3.9 mg/dL, with a nonsignificant group-by-time result. These are changes from baseline within each group; a new direct raw-garlic versus placebo estimate was not calculated. S1	Values, time point, units and change definition for the four groups were attributed as originally recorded. Met concerns retention of values/analysis attribution, without establishing comparative efficacy.	Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions	Material needed: Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionHow do mixed modeling and partial observations relate to ITT and the target effect?Required	The original reason describes retention of 87~90% and inclusion of partial observations in a mixed model. Exact ITT/PP, assignment/adherence effects, model/analysis population and missing-data sensitivity are not recorded. S1	The analytical narrative exists, but inclusion of partial observations was not promoted to complete ITT or verification of a particular target effect.	The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions	Material needed: The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionAre the total 192 and group retention of 87~90% distinct from analysis/completion denominators?Required	The 192 participants are total allocations across 4 arms; retention is recorded as a range of 87~90% by group. Allocation, analysis and completion counts for raw garlic, powder, AGE and placebo, and missingness reasons/timing, are not specifically available in the retained summary. S1	The roles of total allocation, retention range and unverified arm denominators are distinct. Counts or ITT populations were not calculated to fill gaps.	Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing	Material needed: Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionDoes a nonsignificant group-by-time result establish a precise null effect or equivalence?Required	The original result says the group-by-time comparison was nonsignificant; the original reader answer says all three formulations had no statistically or clinically significant effect. A direct raw-garlic versus placebo contrast, CI and exact P are absent from the retained summary. S1	The original no-difference direction is retained, but a precise null effect, equivalence or exclusion of an important effect was not newly established. Original E0/RX are historical verdict values.	Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance	Material needed: Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionHow are bibliography NCT00056511 and the evidence table's unverified registration status retained?Required	The first bibliography and Korean/English research descriptions retain NCT00056511. The first evidence entry's registration status is unverified. Registration, protocol and SAP access/reading were not attempted in this preparation. S1	The retained identifier and structured unverified status remain distinct. Wording at different levels was not converted into plan verification, non-registration or failed access.	NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material	Material needed: NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionAre Garlicin powder and Kyolic AGE arms direct replications of raw garlic?Required; formulation extension requires a separate question	Within the same Gardner 4-arm report, Garlicin powder had a +3.2 and Kyolic AGE a +0.2 mg/dL 6-month change from baseline. The original central explanation says LDL-C results were null in separate analyses. These formulations differ from raw-garlic food. S1	Results for other formulations are retained and attributed as auxiliary comparisons within the same report. They are not independent replications of identical raw garlic or equal-dose comparisons.	Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details	Material needed: Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionWhat scope applies to 25 completers, 0.04 mg/dL and CI/P in the garlic-oil crossover trial?Required; auxiliary context from another formulation	Berthold 1998 is a randomized, double-blind, placebo-controlled crossover trial of garlic oil with 25 completers. The original between-group LDL-C value is 0.04 mg/dL, 95% CI −9.4~9.5, P=.99, recorded as independent null evidence from another formulation. Original units/strings are retained. S2	The separate report's design, completion denominator and between-group value are linked. This is not replication of the same raw-garlic formulation/duration or a result from 25 initially allocated participants.	Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration	Material needed: Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionWhat status applies to older positive high-dose AGE/powder narratives and a separate powder-trial mention?Required	Korean/English counterviews describe LDL reductions in some older high-dose AGE/powder trials; the research description mentions independent oil and powder placebo trials. Only Gardner and Berthold pairs are explicitly present in current evidence/bibliographies. S1 S2	Original positive/opposing background narratives remain, but unidentified high-dose AGE/powder reports or a separate powder trial were not created as new reports.	Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material	Material needed: Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material. This records needed materials; no new research was executed.
24	Unverified	Full text not readStored summary read	N24 · Evidence conditionWere clinical-importance and precision criteria for the between-group LDL-C effect verified?Required	The retained summary does not establish a direct raw-garlic versus placebo effect/CI or an LDL-C important-difference threshold. Original D30, nonsignificance, the total 192 and the oil CI for another formulation do not replace raw-garlic precision/clinical-importance conditions. S1 S2	Original material for comparing the selected raw-garlic reported interval against a justified clinical criterion is unavailable. No new judgment about permitted/excluded important effects was made.	Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators	Material needed: Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators. This records needed materials; no new research was executed.
25	Unverified	Full text not readStored summary read	N25 · Evidence conditionDoes the record answer other doses, subgroups and persistence after treatment?Supplementary; required for an expanded claim	The selected raw-garlic scope is about 4 g on 6 days weekly for 6 months. The retained summary has no direct raw-garlic dose comparison, prespecified effect-modification/subgroup estimate or post-discontinuation persistence value. Other formulations are not raw-garlic dose-response comparisons. S1	Direct information for extended questions could not be established within the retained material. Every extension trial was not made mandatory for the narrow original claim.	Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months	Material needed: Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months. This records needed materials; no new research was executed.
26	Met	Full text not readStored summary read	N26 · Evidence conditionDoes the LDL-C question answer cardiovascular-event prevention or replacement of statins?Supplementary; required for an event/replacement claim	The original verdict selects 6-month LDL-C only and prohibits claims that one clove acts like a statin or use of pooled values from other formulations. Direct cardiovascular-event, death/quality-of-life or statin-replacement results are absent from the retained summary. S1	The LDL-C question is distinct from event/standard-treatment replacement questions. Met concerns limits on interpretation, without establishing event effects.	The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material	Material needed: The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionAre gastrointestinal, odor and allergy cautions observed events in the trial?Supplementary; required for an observed-harm claim	The original caution mentions possible gastrointestinal symptoms, odor and allergy from raw garlic, plus bleeding-risk review with high intake and anticoagulant/antiplatelet use. Event counts, collection/severity and group denominators in the trial are absent from the retained summary. S1 S2	The general original caution is verified, but trial-specific observation, causality and incidence were not established.	Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables	Material needed: Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables. This records needed materials; no new research was executed.
28	Unverified	Full text not readStored summary read	N28 · Evidence conditionWas the timeline of harm onset, stopping, recovery and re-exposure verified?Supplementary; required for a temporal/causal harm claim	6 months of raw-garlic efficacy treatment are recorded, but the original caution has no individual timeline of harm onset, latency, recovery, discontinuation or re-exposure. S1	General cautions and treatment duration alone cannot establish individual-event temporal ordering or causality.	Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records	Material needed: Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records. This records needed materials; no new research was executed.
29	Unverified	Full text not readStored summary read	N29 · Evidence conditionWere harm controls, affected people, exposure denominators and follow-up verified?Supplementary; required for harm incidence/comparison	Efficacy information includes a 4-arm raw-garlic versus food-placebo design with 192 total allocations, and 25 completers for auxiliary oil. The retained summary has no harm people/event counts by group, harm-exposure denominators/follow-up or reported between-group harm estimate. S1 S2	Efficacy controls/sample sizes are distinguished from harm-specific comparisons and denominators. Warnings alone do not permit calculation of frequency or increased risk.	Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material	Material needed: Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material. This records needed materials; no new research was executed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionWhat are the high-intake, anticoagulant/antiplatelet cautions and alternative causes?Supplementary; required for interaction/causal harms	The original text cautions about bleeding-risk review with high intake and anticoagulant/antiplatelet use. Raw-garlic baseline conditions exclude lipid-lowering medicine, but anticoagulant/antiplatelet co-use, events and a numerical high-intake threshold are unavailable. S1	The co-use caution is verified, but this does not establish observed co-use bleeding or confirmed interaction in the raw-garlic 4-g trial.	Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material	Material needed: Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material. This records needed materials; no new research was executed.
31	Unverified	Full text not readStored summary read	N31 · Evidence conditionAre retention/efficacy missingness distinct from harm detection and reporting losses?Supplementary; required for an absence/frequency-of-harm claim	Original retention of 87~90% and the mixed model including partial observations concern LDL efficacy follow-up. Harm collection/detection, events in dropouts, discontinuation reasons and disclosure of all harms are not specified in the retained summary. S1 S2	Efficacy missing-data handling cannot verify complete harm follow-up or absence of harm. Losses were not treated as evidence of harm occurrence.	Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material	Material needed: Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material. This records needed materials; no new research was executed.
32	Unverified	Full text not readStored summary read	N32 · Evidence conditionWere independent cases and report families for the same harm verified?Supplementary; required for a repeated-harm claim	The original material contains Korean/English/synthesis restatements of general cautions and two LDL reports. Identities of unique harm cases, related reports and re-citation families with matching exposure/events are not recorded. S1 S2	Two efficacy reports and original RX/I2 cannot be transferred to independent-harm replication counts. Original cautions remain and unique harm counts stay unverified.	Original material linking unique cases/studies and related reports/re-citations with matching exposures and events	Material needed: Original material linking unique cases/studies and related reports/re-citations with matching exposures and events. This records needed materials; no new research was executed.
33	Unverified	Full text not readStored summary read	N33 · Evidence conditionWhat is known about long-term/rare harms and vulnerable groups beyond 6-month LDL observation?Supplementary; required for long-term/vulnerable-group safety	The selected raw-garlic scope concerns age 30~65, the stated LDL range and 6-month LDL-C, with general cautions. Direct results beyond this scope for long-term/rare harms, other baseline risks, vulnerable groups and combined exposures are not established in the retained summary. S1	A restricted efficacy population/duration differs from overall safety. Every long-term/rare-event trial was not made a required condition for this LDL claim.	Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material	Material needed: Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material. This records needed materials; no new research was executed.
34	Partly verified	Full text not readStored summary read	N34 · Evidence conditionWhat can current material say about harm, harmlessness and causality?Supplementary; required for a safety conclusion	Current verified scope consists of original general cautions and LDL results limited by formulation, duration and denominators. Trial-specific harm counts, controls, denominators, timing and alternative-cause material are unavailable, so incidence, causality and harmlessness were not newly judged. S1 S2	Caution level is distinct from unverified harm. No-difference efficacy and harm-verification status were not merged.	Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material	Material needed: Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material. This records needed materials; no new research was executed.
35	Met	Full text not readStored summary read	N35 · Evidence conditionWere original D30, RX/E0/I2/B1/C0, Korean/English wording, corrections and native values retained as historical text?Required; preservation of history	Original D, integer 30, all axes RX/I2/E0/B1/C0, false/empty strings, Korean/English verdict-decision and synthesis text, corrections, verdict date, empty subclaims and original URLs are retained through a whole typed original-record anchor. Current condition states remain distinct from historical verdict/access narratives. S1 S2	The complete current original/native types, values and events are retained, without transfer to a new score/grade, independent clinical certification or full-text reading.	The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks	Material needed: The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks. This records needed materials; no new research was executed.

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35 itemsWhat the statuses mean

Assessment scope

Stored-material review date: 2026-10-06
Original evidence cut-off: 2026-09-08
Scope actually checked: Retained Korean/English summaries and case-specific condition/application records. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
Population: Adults aged 30~65 with LDL-C 130~190 mg/dL who were not using lipid-lowering medicine. Recruitment, eligibility/exclusion criteria, sex, comorbidities, baseline balance and participant counts by group remain unverified.
Ingredient, formulation and route: Fresh Allium sativum L. cloves of California Early raw garlic were incorporated into sandwiches. The original chemical-characterization description is retained; actual constituent, batch, processing and storage specifications remain unverified. Powder, aged extract and oil remain distinct formulations.
Dose: About one average 4-g clove, 6 days per week. This is the nominal food amount; actual intake, adherence, changes and active-constituent content remain unverified. It is not a personal dosing recommendation or the dose of another formulation.
Comparator: A matched garlic-free sandwich placebo. Actual composition, energy content, provision procedures, changes in accompanying diet or medication and differences between groups remain unverified. Details of the food placebo are not automatically assigned to the powder or aged-extract arms of the same trial.
Measured outcome: The endpoint is change from baseline in LDL-C at 6 months. Retained values are raw garlic +0.4, powder +3.2, AGE +0.2 and placebo −3.9 mg/dL, with a reported nonsignificant group-by-time result. Changes within each group remain distinct from a direct between-group effect, and no new difference was calculated. The direct raw-garlic versus placebo contrast, CI, exact P and clinical-importance criterion remain unverified.
Duration: 6 months of treatment with monthly lipid measurements; the selected endpoint is the final 6-month measurement. Monthly observations are not independent trials. Persistence after treatment and long-term or rare harms remain unverified.
Questions outside this scope: Treating powder, AGE, oil, black garlic, fermented garlic or isolated constituents as interchangeable with raw garlic; Calculating a new between-group effect, CI, P or participant count by subtracting within-group changes; Interpreting nonsignificance as proof of a precise null effect, equivalence or exclusion of an important effect; Extension to an optimal dose, other doses, subgroups or persistence after treatment; Extension to cardiovascular-event prevention, death, quality of life or replacement of statins; Interpreting a general caution as a trial-observed harm, incidence, causality or overall safety; Counting unidentified positive AGE/powder reports or a separate powder-trial narrative as new reports or independent replication

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

S1 · Gardner CD et al. Arch Intern Med. 2007;167:346-353. PMID: 17325296. DOI: 10.1001/archinte.167.4.346. NCT00056511.

PubMed

Material type: Retained summary and bibliography for the raw-garlic/powder/AGE/placebo comparison
Materials actually read: Retained Korean/English summaries, conditions and application records were read. External PubMed, DOI, registration and supplement material remain unread, with access not attempted.
Findings recorded in the stored summary: 192 participants were randomized across all 4 arms; retention by group was 87~90%. Retained 6-month changes from baseline are raw garlic +0.4, powder +3.2, AGE +0.2 and placebo −3.9 mg/dL, with a reported nonsignificant group-by-time result. Allocation, analysis and completion counts by arm, and the direct raw-garlic versus placebo contrast, CI and exact P remain unverified.
Record level: Changes from baseline within each group and the original no-difference description are retained. This does not establish a newly subtracted contrast, a precise null effect, equivalence, independent replication or full ITT status. NIH/NCCAM support and product donation remain distinct; author, donation-contract, involvement and conflict-of-interest details remain unverified.
Study overlap and independent replication: The 2 retained evidence summaries and 2 bibliographies identify the Gardner raw-garlic/powder/AGE/placebo comparison and the separate Berthold garlic-oil report. Korean/English restatements, other arms of the same trial and bibliography/DOI entries are not independent trials. Original-source identities, participant overlap, and unique trial and participant totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored review summary	Locally retained summary	Acquired	Stored existing review summary read	The retained evidence and bibliographic summaries were read. This does not mean the original paper file was acquired or its full text newly verified. This is the retained Gardner summary and bibliography. Powder and AGE in the same trial are other formulations, without establishing independent replication of raw garlic. External PubMed, DOI, registration and supplement material was not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
External bibliography/abstract or original-text entry	Unverified	Access not attempted	Not read	The retained external address is provided. Current responses, public availability, abstract/full-text reading and successful access remain unverified. This is the retained Gardner summary and bibliography. Powder and AGE in the same trial are other formulations, without establishing independent replication of raw garlic. External PubMed, DOI, registration and supplement material was not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
DOI full-text entry	Unverified	Access not attempted	Not read	This is the retained DOI entry for full text. It concerns the same report and is not an independent trial. Full-text existence, public availability, access, downloading and reading were not checked in this preparation. This is the retained Gardner summary and bibliography. Powder and AGE in the same trial are other formulations, without establishing independent replication of raw garlic. External PubMed, DOI, registration and supplement material was not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
Original-paper supplement	Unverified	Access not attempted	Not read	The existence, exact location and original file of a supplement remain unverified. Non-reading does not establish absence of a supplement or a failed access attempt. This is the retained Gardner summary and bibliography. Powder and AGE in the same trial are other formulations, without establishing independent replication of raw garlic. External PubMed, DOI, registration and supplement material was not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
Registration, protocol and analysis plan	Unverified	Access not attempted	Not read	The bibliography contains NCT00056511, while registration status in the original evidence table is not verified. Providing a registration entry does not establish preregistration, plans, current responses or reading of the original record. This is the retained Gardner summary and bibliography. Powder and AGE in the same trial are other formulations, without establishing independent replication of raw garlic. External PubMed, DOI, registration and supplement material was not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.

S2 · Berthold HK et al. JAMA. 1998;279:1900-1902. DOI: 10.1001/jama.279.23.1900.

Official source

Material type: Retained summary and bibliography for a crossover trial of another formulation, garlic oil
Materials actually read: Retained Korean/English summaries, conditions and application records were read. External JAMA, DOI, registration and supplement material remain unread, with access not attempted.
Findings recorded in the stored summary: This is a randomized, double-blind, placebo-controlled crossover trial of garlic oil with 25 completers. The retained between-group LDL-C value is 0.04 mg/dL, 95% CI −9.4~9.5, P=.99. Original units and strings are retained without new correction or conversion. Oil specifications, dose, population, duration, allocation/analysis counts, crossover sequence, washout and carryover handling remain unverified.
Record level: These are auxiliary retained values from another formulation. They are not transferred to the dose, duration, precision or denominator for raw garlic. The original German academic-institution description remains distinct from unverified funding details.
Study overlap and independent replication: The 2 retained evidence summaries and 2 bibliographies identify the Gardner raw-garlic/powder/AGE/placebo comparison and the separate Berthold garlic-oil report. Korean/English restatements, other arms of the same trial and bibliography/DOI entries are not independent trials. Original-source identities, participant overlap, and unique trial and participant totals remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored review summary	Locally retained summary	Acquired	Stored existing review summary read	The retained evidence and bibliographic summaries were read. This does not mean the original paper file was acquired or its full text newly verified. This is the retained Berthold summary and bibliography. Garlic oil is auxiliary context from another formulation and is not counted as direct replication of raw garlic. External originals, registration and supplements were not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
External bibliography/abstract or original-text entry	Unverified	Access not attempted	Not read	The retained external address is provided. Current responses, public availability, abstract/full-text reading and successful access remain unverified. This is the retained Berthold summary and bibliography. Garlic oil is auxiliary context from another formulation and is not counted as direct replication of raw garlic. External originals, registration and supplements were not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
DOI full-text entry	Unverified	Access not attempted	Not read	This is the retained DOI entry for full text. It concerns the same report and is not an independent trial. Full-text existence, public availability, access, downloading and reading were not checked in this preparation. This is the retained Berthold summary and bibliography. Garlic oil is auxiliary context from another formulation and is not counted as direct replication of raw garlic. External originals, registration and supplements were not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
Original-paper supplement	Unverified	Access not attempted	Not read	The existence, exact location and original file of a supplement remain unverified. Non-reading does not establish absence of a supplement or a failed access attempt. This is the retained Berthold summary and bibliography. Garlic oil is auxiliary context from another formulation and is not counted as direct replication of raw garlic. External originals, registration and supplements were not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.
Registration, protocol and analysis plan	Unverified	Access not attempted	Not read	The registration identifier, protocol and analysis plan remain unverified. This does not establish non-registration or a failed access attempt. This is the retained Berthold summary and bibliography. Garlic oil is auxiliary context from another formulation and is not counted as direct replication of raw garlic. External originals, registration and supplements were not read or accessed in this preparation. The material-check date distinguishes verification and reading status in the retained record. It is not a new external-original access date or a search cutoff.

Report counts versus independent study counts

The 2 retained evidence summaries and 2 bibliographies identify the Gardner raw-garlic/powder/AGE/placebo comparison and the separate Berthold garlic-oil report. Korean/English restatements, other arms of the same trial and bibliography/DOI entries are not independent trials. Original-source identities, participant overlap, and unique trial and participant totals remain unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which raw-garlic LDL-C question does this table link to the original claim?

Required materials and conditions: The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary
Conditions for verification: Link California Early raw garlic, food intake, about 4 g on 6 days weekly for 6 months, the stated population, LDL-C and matched garlic-free sandwich placebo to the original description.
Requirement and applicability: Required
Application exceptions: Keep powder, AGE and oil reports as formulation-specific auxiliary context without automatically extending them to new independent questions or general garlic efficacy.
Why this condition is needed: This is needed to keep a broad ingredient claim distinct from the narrow LDL-C question for the original raw-garlic formulation.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N02 · Who is covered by the LDL-C range, age range and absence of lipid-lowering medicine?

Required materials and conditions: The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables
Conditions for verification: Distinguish the original population from unverified populations in auxiliary trials of other formulations, and state limits concerning eligibility, baseline characteristics and representativeness.
Requirement and applicability: Required
Application exceptions: Do not use the total of 192 across 4 arms as the raw-garlic count. Do not infer that recruitment, sex/comorbidities or baseline differences were absent.
Why this condition is needed: A population contract is needed so that the label moderate hypercholesterolemia is not generalized to other groups.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N03 · Were the California Early raw-garlic food formulation and chemical specifications verified?

Required materials and conditions: Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications
Conditions for verification: Link the original raw-garlic formulation to unverified specifications, without transferring doses or effects from other formulations.
Requirement and applicability: Required
Application exceptions: Do not present the original chemical-characterization narrative as acquisition of the constituent report in this preparation, or convert the nominal 4 g to active-constituent content.
Why this condition is needed: This is needed to distinguish raw-garlic food from powder, AGE, oil, allicin, black/fermented garlic and isolated SAC.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N04 · Is the comparator a matched garlic-free sandwich placebo?

Required materials and conditions: The original food-placebo description and methods for food provision, energy/constituents and control treatment
Conditions for verification: Retain the original raw-garlic versus matched garlic-free sandwich-placebo contract and state the verified extent of actual composition and treatment details.
Requirement and applicability: Required
Application exceptions: Do not transfer raw-garlic food-placebo details unchanged to powder/AGE comparisons in the same 4-arm trial. An efficacy placebo alone does not certify a harm comparison.
Why this condition is needed: The actual direction of the raw-garlic versus placebo comparison and the food-control content must be clear.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N05 · Are the nominal about 4-g amount on 6 days weekly and actual intake/adherence distinct?

Required materials and conditions: The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records
Conditions for verification: Retain original nominal amount/frequency and separately state unverified actual intake and group-specific departures/changes.
Requirement and applicability: Required
Application exceptions: Do not calculate new daily active-constituent or cumulative amounts from 6 days weekly and 6 months. Do not fill powder/AGE doses with the raw-garlic amount.
Why this condition is needed: This is needed to avoid assuming that nominal food amount and actual exposure were identical.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N06 · Are 6-month treatment, monthly measurements and the final 6-month endpoint distinct?

Required materials and conditions: 6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions
Conditions for verification: Attribute stated treatment duration, measurement frequency and the selected final time point to the original record, retaining unverified longer follow-up.
Requirement and applicability: Required
Application exceptions: Do not create persistence effects, clinical events or new minimum-duration criteria beyond 6 months.
Why this condition is needed: This is needed to avoid counting monthly measurements as independent trials or separate replications of the final endpoint.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N07 · Are 4-arm reporting, bibliographies and the total 192 kept free of duplicate counting?

Required materials and conditions: Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links
Conditions for verification: Link each evidence/bibliography pair, the four arms and Korean/English restatements within a local report context; keep unique trial and participant totals unverified.
Requirement and applicability: Required
Application exceptions: Do not treat 192 as each arm's count, multiply participant counts by 3 or assume 48 per arm. Do not add the 25 Berthold completers from another report.
Why this condition is needed: This is needed to avoid multiplying the three garlic arms and shared placebo into separate trials or repeated participants.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N08 · Are the local summaries actually read distinguished from external material remaining unread?

Required materials and conditions: Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report
Conditions for verification: Link current local-summary reading to the original locations, and record actual non-attempt/non-reading separately for external abstracts, full texts, supplements and registrations.
Requirement and applicability: Required
Application exceptions: Do not label unattempted external access as inaccessible. Reusing method-HTML identity and hashes does not establish complete full-text reading.
Why this condition is needed: This is needed to avoid converting PubMed, DOI, JAMA and NCT links into successful abstract/full-text/registration reading.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N09 · What are the verdict date, correction history, current review date and evidence-date scope?

Required materials and conditions: Original verdict date, corrections, Korean/English and synthesis text, and actual current review time
Conditions for verification: Preserve all original date/correction fields and both languages, distinguishing actual local reading and the absence of a new search.
Requirement and applicability: Required
Application exceptions: Keep unavailable original search cutoffs and material-specific access dates/levels unverified. Generic English wording must not be promoted to new verification.
Why this condition is needed: This is needed to avoid retroactively treating the original 2026-09-08 verdict and 9/14 English correction as a current comprehensive search or current full-text reading.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N10 · What is verified about NIH/NCCAM support, product donation and oil-report funding?

Required materials and conditions: Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material
Conditions for verification: Link actual retained support wording for each report separately from unverified declarations, employment, institutions and family relationships.
Requirement and applicability: Supplementary; required for an independence claim
Application exceptions: Do not automatically discard results because support or donation exists. Original I2/B1 assessments remain historical only.
Why this condition is needed: This is needed to avoid certifying absence of conflicts, independent replication or absence of bias from the original independent-funding description alone.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N11 · What actual 4-arm parallel randomized design does the main trial have?

Required materials and conditions: The original 4-arm randomized parallel design, arm composition, allocation methods and methods section
Conditions for verification: Link Gardner's 4-arm parallel randomized design and the other report's crossover design separately, limiting claims to verified design descriptions.
Requirement and applicability: Required
Application exceptions: The term randomized alone does not verify concealment, balance or elimination of bias. Preserve the oil crossover trial as another report.
Why this condition is needed: This is needed to avoid changing the original design into crossover, cluster randomization or three separate direct trials.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N12 · Were allocation concealment, baseline balance and actual blinding implementation verified?

Required materials and conditions: Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material
Conditions for verification: Verify actual implementation/differences at the original locations, or specifically state current limits of unverified information.
Requirement and applicability: Required
Application exceptions: Do not automatically judge food blinding impossible. Objective LDL-C alone does not establish absence of measurement bias.
Why this condition is needed: This is needed to avoid inventing complete food-intake blinding or verified protection of RCT allocation.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N13 · What changes in diet, concomitant medicine and rescue treatment occurred by group?

Required materials and conditions: Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group
Conditions for verification: Distinguish baseline conditions from actual concomitant use/changes during follow-up and analytical effects, retaining unverified group-specific details.
Requirement and applicability: Required
Application exceptions: Baseline absence of lipid-lowering medicine does not establish absence of all concomitant use/changes over 6 months. Do not invent change values or assume balance.
Why this condition is needed: This is needed to avoid attributing other treatment/diet changes to raw-garlic LDL-C changes.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N14 · Were LDL-C methods, laboratory conditions and measurement procedures by group verified?

Required materials and conditions: LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material
Conditions for verification: Link selected LDL-C results to measurement frequency and units, stating unverified actual testing conditions and assessment procedures.
Requirement and applicability: Required
Application exceptions: Do not substitute total cholesterol, TG or HDL for LDL-C or convert original values to another unit without authorization.
Why this condition is needed: The same LDL-C label does not establish identical testing conditions, measurement error or group differences.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N15 · Are 6-month LDL-C, other lipid endpoints and prespecified outcome hierarchy distinct?

Required materials and conditions: The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables
Conditions for verification: Link retained principal LDL-C endpoint/time point and limits on substituting other lipids, separately stating the extent of comparison with prespecified plans.
Requirement and applicability: Required
Application exceptions: Preserve the original primary (1st) designation, while registry/selection-reporting comparison remains unverified because originals were not read. Do not create new values for other lipids.
Why this condition is needed: This is needed to avoid replacing the original LDL-C result with other lipids or a favorable time point.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N16 · What changes do +0.4, +3.2, +0.2 and −3.9 represent in the four groups?

Required materials and conditions: Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions
Conditions for verification: Retain each group's original change, units and time point, distinguishing the nonsignificant group-by-time narrative from the unverified direct contrast.
Requirement and applicability: Required
Application exceptions: Do not subtract raw garlic and placebo to create a new effect estimate/CI. Do not interpret a plus sign as positive efficacy.
Why this condition is needed: This is needed to avoid misreading within-group changes as between-group effects, positive efficacy or a garlic effect from placebo reduction.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N17 · How do mixed modeling and partial observations relate to ITT and the target effect?

Required materials and conditions: The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions
Conditions for verification: Retain original analytical wording and explain unverified exact populations, model, target estimate, sensitivity and departure handling.
Requirement and applicability: Required
Application exceptions: Do not infer absence of missing-data bias from retention alone or invent PP/ITT/model details.
Why this condition is needed: This is needed to avoid converting inclusion of partial data into verification of full ITT or a particular target effect.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N18 · Are the total 192 and group retention of 87~90% distinct from analysis/completion denominators?

Required materials and conditions: Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing
Conditions for verification: Retain the original overall denominator/retention range while separating unverified denominators and missingness in raw-garlic, powder, AGE and placebo arms.
Requirement and applicability: Required
Application exceptions: Do not calculate completion/analysis counts from the retention range or assume 48 per group or ITT 192.
Why this condition is needed: This is needed to avoid converting the displayed sample size and retention range into the actual raw-garlic analysis denominator.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N19 · Does a nonsignificant group-by-time result establish a precise null effect or equivalence?

Required materials and conditions: Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance
Conditions for verification: Retain the original no-difference direction alongside unverified direct contrast/CI/exact P, without creating a new precise null effect or grade.
Requirement and applicability: Required
Application exceptions: Original E0/RX labels are historical verdicts, without a new precision/exclusion-interval check. A plus change within a group is not positive efficacy.
Why this condition is needed: This is needed to avoid automatically promoting nonsignificance or an original null assessment into proof of an effect of 0 or equivalence.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N20 · How are bibliography NCT00056511 and the evidence table's unverified registration status retained?

Required materials and conditions: NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material
Conditions for verification: Link both original fields separately; comparison with prespecified LDL-C, analysis and time plans remains externally unread.
Requirement and applicability: Required
Application exceptions: Do not call unverified registration non-registration. An NCT string does not establish preregistration/plans or successful access.
Why this condition is needed: The identifier string must remain distinct from actual reading of the original registration or prespecified plans.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N21 · Are Garlicin powder and Kyolic AGE arms direct replications of raw garlic?

Required materials and conditions: Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details
Conditions for verification: Attribute powder +3.2 and AGE +0.2 mg/dL within the same report family as auxiliary comparisons of other formulations, limiting claims about raw-garlic effects and independence.
Requirement and applicability: Required; formulation extension requires a separate question
Application exceptions: Powder/AGE doses remain unverified in the original material; do not transfer raw-garlic 4-g food/placebo conditions. Do not delete the other formulations' results.
Why this condition is needed: This is needed to avoid counting no-difference results from other formulations within one report as independent replication of identical raw garlic.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N22 · What scope applies to 25 completers, 0.04 mg/dL and CI/P in the garlic-oil crossover trial?

Required materials and conditions: Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration
Conditions for verification: Link the separate report, crossover design, 25 completers and attribution of original between-group values, without transfer to raw-garlic formulation, duration or denominators.
Requirement and applicability: Required; auxiliary context from another formulation
Application exceptions: Preserve original mg/dL, CI and P without unrequested correction/conversion because of suspected units. Retain unverified oil dose, duration, population, sequence, washout and carryover handling.
Why this condition is needed: This is needed to avoid treating a separate oil result as raw-garlic food, direct 6-month replication or an allocation result for all 25.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N23 · What status applies to older positive high-dose AGE/powder narratives and a separate powder-trial mention?

Required materials and conditions: Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material
Conditions for verification: Link the existence of background narratives to unverified identity/values/access, without automatically labeling different questions as conflicting data.
Requirement and applicability: Required
Application exceptions: There are currently 2 evidence entries/bibliographies. Unidentified positive AGE/powder or independent-powder-trial narratives must not generate S3, a new bibliography or independent-replication counts.
Why this condition is needed: This is needed to preserve formulation/design differences between positive background and the current direct no-difference result without inventing unverified reports.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N24 · Were clinical-importance and precision criteria for the between-group LDL-C effect verified?

Required materials and conditions: Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators
Conditions for verification: Distinguish availability of a selected raw-garlic CI and a justified importance criterion; if unavailable, explain that the range of important effects cannot be interpreted.
Requirement and applicability: Required
Application exceptions: Do not invent a minimum sample size, duration, MID, equivalence threshold or new score. Do not apply the oil CI to raw-garlic precision.
Why this condition is needed: 192 participants, nonsignificance and original D30 alone cannot establish precision or exclusion of an important effect.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N25 · Does the record answer other doses, subgroups and persistence after treatment?

Required materials and conditions: Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months
Conditions for verification: Limit the current direct scope and separately retain unverified extended questions and their estimates.
Requirement and applicability: Supplementary; required for an expanded claim
Application exceptions: Do not require every extension trial to satisfy the narrow original main claim. An optimal amount, minimum duration and subgroup results absent from the original material remain unverified.
Why this condition is needed: This is needed to avoid extending an LDL-C result for one food amount/duration to an optimal dose, responder group or persistence effect.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N26 · Does the LDL-C question answer cardiovascular-event prevention or replacement of statins?

Required materials and conditions: The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material
Conditions for verification: Distinguish the direct LDL-C scope from separate clinical questions, retaining original statin-advertising limits and unverified direct event material.
Requirement and applicability: Supplementary; required for an event/replacement claim
Application exceptions: Do not require an event trial for the LDL-C-change question, but do not claim verified event/replacement effects.
Why this condition is needed: This is needed to avoid transferring retained lipid results to cardiovascular events or replacement of standard treatment.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N27 · Are gastrointestinal, odor and allergy cautions observed events in the trial?

Required materials and conditions: Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables
Conditions for verification: Separate a general caution from unverified trial-specific event counts, collection and causality; do not delete efficacy observations because of harm results.
Requirement and applicability: Supplementary; required for an observed-harm claim
Application exceptions: The lack of individual-harm results in the retained text must not be extended to non-reporting in the whole external paper or 0 adverse effects.
Why this condition is needed: This is needed to avoid promoting general cautions into trial-observed event counts, causes or safety assessments.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N28 · Was the timeline of harm onset, stopping, recovery and re-exposure verified?

Required materials and conditions: Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records
Conditions for verification: Distinguish exposure duration from individual-event timing, retaining unverified status when actual records are unavailable.
Requirement and applicability: Supplementary; required for a temporal/causal harm claim
Application exceptions: The original general caution has no individual timeline. Do not infer improvement after stopping, positive re-exposure or latency.
Why this condition is needed: This is needed to avoid treating 6-month exposure as the onset time or cause of individual symptoms.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N29 · Were harm controls, affected people, exposure denominators and follow-up verified?

Required materials and conditions: Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material
Conditions for verification: Link the verified extent of harm-specific controls, events and exposure denominators/follow-up without inventing comparative estimates as original values.
Requirement and applicability: Supplementary; required for harm incidence/comparison
Application exceptions: Do not fill proportions, RR or background incidence from general warnings without harm events/denominators. An efficacy control is distinct from a verified harm comparison.
Why this condition is needed: This is needed to avoid using the efficacy 4-arm placebo, 192 allocations or 25 oil completers as denominators for harm frequency/risk ratios.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N30 · What are the high-intake, anticoagulant/antiplatelet cautions and alternative causes?

Required materials and conditions: Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material
Conditions for verification: Distinguish original co-use cautions from unverified actual simultaneous exposure, alternatives and group risks, without personal dosing instructions or a new safety judgment.
Requirement and applicability: Supplementary; required for interaction/causal harms
Application exceptions: A numerical high-intake threshold, co-use events and baseline-risk balance remain unverified. Absence of lipid-lowering medicine does not mean no anticoagulant/antiplatelet use.
Why this condition is needed: This is needed to avoid converting caution wording into proof of co-use bleeding or a dose threshold in this raw-garlic 4-g trial.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N31 · Are retention/efficacy missingness distinct from harm detection and reporting losses?

Required materials and conditions: Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material
Conditions for verification: Separate efficacy follow-up from verification of harm collection/reporting, retaining possible selection/detection limitations as unverified.
Requirement and applicability: Supplementary; required for an absence/frequency-of-harm claim
Application exceptions: Do not conversely infer harms occurred because of losses. Distinguish absence from the original summary from non-reporting in the entire paper.
Why this condition is needed: Efficacy retention/inclusion of partial observations alone cannot verify that all harms were followed and counted.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N32 · Were independent cases and report families for the same harm verified?

Required materials and conditions: Original material linking unique cases/studies and related reports/re-citations with matching exposures and events
Conditions for verification: Link verified original cautions to unverified actual independent-harm material, retaining unknown case/participant/replication counts as unverified.
Requirement and applicability: Supplementary; required for a repeated-harm claim
Application exceptions: The current material lacks unique harm-case/related-registration identity. Do not transfer original efficacy RX/I2 or the 2 reports to harm independence.
Why this condition is needed: This is needed to avoid counting repeated general cautions, two LDL reports or Korean/English/synthesis restatements as independent harm replication.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N33 · What is known about long-term/rare harms and vulnerable groups beyond 6-month LDL observation?

Required materials and conditions: Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material
Conditions for verification: Distinguish stated population/duration from unverified direct information for separate long-term/vulnerable-group harm questions.
Requirement and applicability: Supplementary; required for long-term/vulnerable-group safety
Application exceptions: Do not require every rare-harm study for the current LDL question or invent a minimum follow-up duration or sample size.
Why this condition is needed: This is needed to avoid generalizing a limited population and 6-month lipid result to overall safety.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N34 · What can current material say about harm, harmlessness and causality?

Required materials and conditions: Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material
Conditions for verification: State the extent of caution, unverified trial-specific harms and inability to create new causality/incidence estimates.
Requirement and applicability: Supplementary; required for a safety conclusion
Application exceptions: Preserve cautions without personal dosing/stopping instructions or clinical certification. Unverified harms must not erase the LDL result itself.
Why this condition is needed: This is needed to avoid turning no-difference efficacy and general cautions into harmlessness, confirmed causality or a new safety grade.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

N35 · Were original D30, RX/E0/I2/B1/C0, Korean/English wording, corrections and native values retained as historical text?

Required materials and conditions: The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks
Conditions for verification: Preserve the whole typed original and historical dates/values while distinguishing current observations, states, access and review.
Requirement and applicability: Required; preservation of history
Application exceptions: The original score is integer 30; subclaims remain empty, and false/empty strings and corrections retain their native types. No new grade, calculation or translation correction was performed.
Why this condition is needed: This is needed to prevent original score, replication, null and independence labels from being inherited as new condition fulfillment, current full-text reading or precision certification.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Retained method-application records were reused. External originals were not reread and method content was not reassessed.

What the statuses mean

Met: The stated conditions for retained information, attribution, reading, counting or interpretation boundaries are verified. This is not certification of efficacy, full-text reading or reassessment.
Partly verified: Some retained information is verified and necessary unverified material remains.
Unverified: The criterion could not be established within the retained material. This does not mean no studies, no effect or established safety.
Not reported: This is limited to the item not being stated in the particular material or section that was read.
Inaccessible: Used only for material where an actual access attempt failed. This status was not assigned to clinical material in this preparation.
Not applicable: A specific exception under the applicability conditions; it is not a substitute for material remaining unread.
Review incomplete: The necessary source comparison or search was not performed within the authorized scope.
Conflicting data: Used when incompatible material has been compared for the same question, time point and analysis. Numerical differences between summaries alone do not establish this status.

Change history

2026-10-25 · Public page/material version 1.0

The public view and materials were prepared from the existing 35 items. No new clinical search, verification-state change or scoring was performed.

The stored-material review date (2026-10-06) and original evidence cut-off (2026-09-08) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which raw-garlic LDL-C question does this table link to the original claim?

Current findings: The original outcome is LDL-C reduction in adults with moderate hypercholesterolemia. California Early raw garlic was supplied in sandwiches at about one average 4-g clove, 6 days weekly for 6 months, against matched garlic-free sandwich placebo. The endpoint is 6-month LDL-C change from baseline. Powder, AGE and oil provide formulation-specific auxiliary context.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The current Korean claim, Korean/English descriptors and scope note are linked to the final raw-garlic main-question selection. This status verifies question identity and scope, without establishing raw-garlic efficacy.
Reason for missing information: The selected raw-garlic between-group estimate/CI, arm-specific denominators and external methods remain unverified. No separate questions or tables for other formulations were created here.
Required materials and conditions: The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary
Materials to obtain first: The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary
Further research: Material needed: The current Korean claim, Korean/English intervention and population descriptors, scope note and selected question boundary. This records needed materials; no new research was executed.
Remaining uncertainty: The selected raw-garlic between-group estimate/CI, arm-specific denominators and external methods remain unverified. No separate questions or tables for other formulations were created here.
Conditions for verification: Link California Early raw garlic, food intake, about 4 g on 6 days weekly for 6 months, the stated population, LDL-C and matched garlic-free sandwich placebo to the original description.
Why this condition is needed: This is needed to keep a broad ingredient claim distinct from the narrow LDL-C question for the original raw-garlic formulation.
Application exceptions: Keep powder, AGE and oil reports as formulation-specific auxiliary context without automatically extending them to new independent questions or general garlic efficacy.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N02 · Who is covered by the LDL-C range, age range and absence of lipid-lowering medicine?

Current findings: The main population is adults aged 30~65 with LDL-C 130~190 mg/dL who were not using lipid-lowering medicine. The total of 192 is the allocation denominator across all 4 arms. The oil report records only 25 completers; direct identity with the raw-garlic population is unverified.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Original raw-garlic population conditions are specific, but recruitment/eligibility, baseline tables, representativeness and arm-specific denominators are unavailable in the retained summary.
Reason for missing information: Detailed eligibility/exclusion criteria, baseline balance, comorbidities/sex and actual allocation, analysis and completion counts for raw garlic remain unverified.
Required materials and conditions: The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables
Materials to obtain first: The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables
Further research: Material needed: The original population description of LDL-C 130~190 mg/dL, age 30~65 and no medicine use, plus eligibility/exclusion and baseline-balance tables. This records needed materials; no new research was executed.
Remaining uncertainty: Detailed eligibility/exclusion criteria, baseline balance, comorbidities/sex and actual allocation, analysis and completion counts for raw garlic remain unverified.
Conditions for verification: Distinguish the original population from unverified populations in auxiliary trials of other formulations, and state limits concerning eligibility, baseline characteristics and representativeness.
Why this condition is needed: A population contract is needed so that the label moderate hypercholesterolemia is not generalized to other groups.
Application exceptions: Do not use the total of 192 across 4 arms as the raw-garlic count. Do not infer that recruitment, sex/comorbidities or baseline differences were absent.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N03 · Were the California Early raw-garlic food formulation and chemical specifications verified?

Current findings: The original formulation is California Early raw garlic from fresh Allium sativum L. cloves supplied in sandwiches as food. The Korean/English ingredient descriptions state chemically characterized material equivalent to about 4 g; product descriptions prohibit interchange with other garlic formulations.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Raw-garlic food/material identity is stated. Chemical-characterization wording is retained, but the actual analytical table and batch/specifications were not newly acquired.
Reason for missing information: Original constituent-content, batch, processing/storage and exposure-specification data remain unverified. About 4 g was not converted into allicin/SAC content.
Required materials and conditions: Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications
Materials to obtain first: Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications
Further research: Material needed: Fresh cloves, sandwich provision and the original chemical-characterization description, with original batch, constituent and processing specifications. This records needed materials; no new research was executed.
Remaining uncertainty: Original constituent-content, batch, processing/storage and exposure-specification data remain unverified. About 4 g was not converted into allicin/SAC content.
Conditions for verification: Link the original raw-garlic formulation to unverified specifications, without transferring doses or effects from other formulations.
Why this condition is needed: This is needed to distinguish raw-garlic food from powder, AGE, oil, allicin, black/fermented garlic and isolated SAC.
Application exceptions: Do not present the original chemical-characterization narrative as acquisition of the constituent report in this preparation, or convert the nominal 4 g to active-constituent content.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N04 · Is the comparator a matched garlic-free sandwich placebo?

Current findings: The original raw-garlic comparator is a matched garlic-free sandwich placebo. Powder, AGE and placebo changes are also reported in the same 4-arm trial, but actual placebo/treatment details for the other formulations remain separately unverified.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The original placebo contract for selected raw garlic was verified. Detailed food composition/energy, provision and treatments in other groups were not verified.
Reason for missing information: Food composition beyond garlic, provision/intake conditions by group and powder/AGE placebo details remain unverified because the original methods were not read.
Required materials and conditions: The original food-placebo description and methods for food provision, energy/constituents and control treatment
Materials to obtain first: The original food-placebo description and methods for food provision, energy/constituents and control treatment
Further research: Material needed: The original food-placebo description and methods for food provision, energy/constituents and control treatment. This records needed materials; no new research was executed.
Remaining uncertainty: Food composition beyond garlic, provision/intake conditions by group and powder/AGE placebo details remain unverified because the original methods were not read.
Conditions for verification: Retain the original raw-garlic versus matched garlic-free sandwich-placebo contract and state the verified extent of actual composition and treatment details.
Why this condition is needed: The actual direction of the raw-garlic versus placebo comparison and the food-control content must be clear.
Application exceptions: Do not transfer raw-garlic food-placebo details unchanged to powder/AGE comparisons in the same 4-arm trial. An efficacy placebo alone does not certify a harm comparison.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N05 · Are the nominal about 4-g amount on 6 days weekly and actual intake/adherence distinct?

Current findings: The nominal intake is about one average 4-g clove on 6 days weekly. Actual batch amount, intake/adherence records and changes by group are not specified in the retained summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Nominal amount and frequency link to the original description, but actual-exposure, adherence and departure conditions could not be verified.
Reason for missing information: Actual intake, cumulative exposure, adherence by group, discontinuation/changes and doses of other formulations remain unverified. No new conversion was made.
Required materials and conditions: The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records
Materials to obtain first: The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records
Further research: Material needed: The original about one average 4-g clove amount on 6 days weekly, plus batch amount, actual intake and adherence/discontinuation records. This records needed materials; no new research was executed.
Remaining uncertainty: Actual intake, cumulative exposure, adherence by group, discontinuation/changes and doses of other formulations remain unverified. No new conversion was made.
Conditions for verification: Retain original nominal amount/frequency and separately state unverified actual intake and group-specific departures/changes.
Why this condition is needed: This is needed to avoid assuming that nominal food amount and actual exposure were identical.
Application exceptions: Do not calculate new daily active-constituent or cumulative amounts from 6 days weekly and 6 months. Do not fill powder/AGE doses with the raw-garlic amount.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N06 · Are 6-month treatment, monthly measurements and the final 6-month endpoint distinct?

Current findings: Original descriptors separately record 6 months of treatment with monthly lipid measurements and 6-month LDL-C change from baseline. The selected result is the final 6-month endpoint; monthly observations are not independent trials.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Stated treatment duration, measurement frequency and the selected time point are distinguished as originally recorded. Met concerns temporal attribution, without establishing longer-term persistence.
Reason for missing information: Exact visit windows/individual follow-up days and persistence after stopping or beyond 6 months remain unverified. The original duration was not adopted as a universal minimum.
Required materials and conditions: 6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions
Materials to obtain first: 6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions
Further research: Material needed: 6-month treatment, monthly lipid measurements, 6-month LDL-C change from baseline and visit/follow-up conditions. This records needed materials; no new research was executed.
Remaining uncertainty: Exact visit windows/individual follow-up days and persistence after stopping or beyond 6 months remain unverified. The original duration was not adopted as a universal minimum.
Conditions for verification: Attribute stated treatment duration, measurement frequency and the selected final time point to the original record, retaining unverified longer follow-up.
Why this condition is needed: This is needed to avoid counting monthly measurements as independent trials or separate replications of the final endpoint.
Application exceptions: Do not create persistence effects, clinical events or new minimum-duration criteria beyond 6 months.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N07 · Are 4-arm reporting, bibliographies and the total 192 kept free of duplicate counting?

Current findings: The main Gardner report is a 4-arm randomized parallel trial with 192 allocated in total. The first evidence entry, first bibliography and Korean/English descriptions are linked as restatements of the same report. The Berthold 1998 oil report/bibliography is separate auxiliary context from another formulation.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The 2 local reports and 2 bibliographies, and identity within each pair, are linked. Original registrations, related reports, recruitment identity and total independent-trial/participant counts were not newly verified.
Reason for missing information: The three garlic arms were not counted as 3 trials, and 192 was not treated as an arm count or multiplied by 3. Unique trial and participant totals across the reports remain unverified.
Required materials and conditions: Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links
Materials to obtain first: Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links
Further research: Material needed: Identity of the original Gardner report/bibliography, the 4-arm structure, total allocation of 192 and report-family/participant links. This records needed materials; no new research was executed.
Remaining uncertainty: The three garlic arms were not counted as 3 trials, and 192 was not treated as an arm count or multiplied by 3. Unique trial and participant totals across the reports remain unverified.
Conditions for verification: Link each evidence/bibliography pair, the four arms and Korean/English restatements within a local report context; keep unique trial and participant totals unverified.
Why this condition is needed: This is needed to avoid multiplying the three garlic arms and shared placebo into separate trials or repeated participants.
Application exceptions: Do not treat 192 as each arm's count, multiply participant counts by 3 or assume 48 per arm. Do not add the 25 Berthold completers from another report.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N08 · Are the local summaries actually read distinguished from external material remaining unread?

Current findings: The entire current 3058 retained summary and byte-identical snapshot were read. Retained summaries/bibliographies for both reports and exact original locations, data types and source-identity checks were linked. PubMed, DOI, JAMA, NCT and supplements were not accessed or read; identity/source-identity checks for 5 method HTML files was reused.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Actual current local-summary reading and external non-reading are separated by material. A link does not establish abstract/full-text access or acquisition.
Reason for missing information: Historical material-specific access dates, reading levels and original locations have no native keys. No external access failure occurred in this preparation, so material was not labeled inaccessible.
Required materials and conditions: Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report
Materials to obtain first: Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report
Further research: Material needed: Exact locations, data types, source-identity checks and actual review time in the current summary, with external URLs/access records for each report. This records needed materials; no new research was executed.
Remaining uncertainty: Historical material-specific access dates, reading levels and original locations have no native keys. No external access failure occurred in this preparation, so material was not labeled inaccessible.
Conditions for verification: Link current local-summary reading to the original locations, and record actual non-attempt/non-reading separately for external abstracts, full texts, supplements and registrations.
Why this condition is needed: This is needed to avoid converting PubMed, DOI, JAMA and NCT links into successful abstract/full-text/registration reading.
Application exceptions: Do not label unattempted external access as inaccessible. Reusing method-HTML identity and hashes does not establish complete full-text reading.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N09 · What are the verdict date, correction history, current review date and evidence-date scope?

Current findings: The original verdict date is 2026-09-08. The 2026-09-14 English evidence-table placeholder correction is a historical event retaining grade D, without new research/reassessment. Current Korean/English wording, synthesis and generic evidence statements are preserved as originally stored. The current date denotes actual local review.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Historical review/correction dates are distinct from actual current reading and search scope. Dates were not used as proof of a new comprehensive literature search or full-text access.
Reason for missing information: Historical access dates/levels by report and the evidence-search cutoff are unavailable and remain unverified. Generic verified/assessed wording is not independent verification in this preparation.
Required materials and conditions: Original verdict date, corrections, Korean/English and synthesis text, and actual current review time
Materials to obtain first: Original verdict date, corrections, Korean/English and synthesis text, and actual current review time
Further research: Material needed: Original verdict date, corrections, Korean/English and synthesis text, and actual current review time. This records needed materials; no new research was executed.
Remaining uncertainty: Historical access dates/levels by report and the evidence-search cutoff are unavailable and remain unverified. Generic verified/assessed wording is not independent verification in this preparation.
Conditions for verification: Preserve all original date/correction fields and both languages, distinguishing actual local reading and the absence of a new search.
Why this condition is needed: This is needed to avoid retroactively treating the original 2026-09-08 verdict and 9/14 English correction as a current comprehensive search or current full-text reading.
Application exceptions: Keep unavailable original search cutoffs and material-specific access dates/levels unverified. Generic English wording must not be promoted to new verification.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N10 · What is verified about NIH/NCCAM support, product donation and oil-report funding?

Current findings: NIH/NCCAM support and product donation are recorded for the main report. The oil report identifies a German academic institution, with funding details unverified. Original axis I2 and the original rationale's independent-funding assessment remain historical values.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Original support levels are separated by report, but complete COI, provision contracts/involvement, author employment/patents and institutional links were not read in this preparation.
Reason for missing information: Full COI declarations, donor/conditions, involvement in products/analysis, author details and family independence remain unverified.
Required materials and conditions: Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material
Materials to obtain first: Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material
Further research: Material needed: Main-report NIH/NCCAM support/product donation, the oil report's German academic institution/unverified details, and COI, author and product-provision material. This records needed materials; no new research was executed.
Remaining uncertainty: Full COI declarations, donor/conditions, involvement in products/analysis, author details and family independence remain unverified.
Conditions for verification: Link actual retained support wording for each report separately from unverified declarations, employment, institutions and family relationships.
Why this condition is needed: This is needed to avoid certifying absence of conflicts, independent replication or absence of bias from the original independent-funding description alone.
Application exceptions: Do not automatically discard results because support or donation exists. Original I2/B1 assessments remain historical only.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N11 · What actual 4-arm parallel randomized design does the main trial have?

Current findings: The original main-trial design is a 4-arm randomized parallel trial. The original central explanation describes separate analyses of raw garlic, Garlicin powder and Kyolic AGE. Auxiliary oil is a different randomized, double-blind, placebo-controlled crossover design.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Design names and the 4-arm composition are linked to the original record, but randomization/allocation and detailed original methods remain unverified. Parallel and crossover trials were not merged into one design.
Reason for missing information: Main-report allocation implementation, concealment/baseline and blinding remain unverified, as do crossover sequence, washout, period and carryover handling for oil.
Required materials and conditions: The original 4-arm randomized parallel design, arm composition, allocation methods and methods section
Materials to obtain first: The original 4-arm randomized parallel design, arm composition, allocation methods and methods section
Further research: Material needed: The original 4-arm randomized parallel design, arm composition, allocation methods and methods section. This records needed materials; no new research was executed.
Remaining uncertainty: Main-report allocation implementation, concealment/baseline and blinding remain unverified, as do crossover sequence, washout, period and carryover handling for oil.
Conditions for verification: Link Gardner's 4-arm parallel randomized design and the other report's crossover design separately, limiting claims to verified design descriptions.
Why this condition is needed: This is needed to avoid changing the original design into crossover, cluster randomization or three separate direct trials.
Application exceptions: The term randomized alone does not verify concealment, balance or elimination of bias. Preserve the oil crossover trial as another report.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N12 · Were allocation concealment, baseline balance and actual blinding implementation verified?

Current findings: The retained summary identifies the main trial as randomized with 4 arms, but provides no random-sequence method, allocation concealment, baseline table by group, food/product blinding or assessor-handling details.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The randomized label alone cannot establish allocation protection, balance or blinding. This is an information gap within current local reading.
Reason for missing information: Allocation/concealment, baseline balance and actual blinding/assessor procedures remain unverified. Neither impossibility of food blinding nor absence/confirmation of bias was inferred.
Required materials and conditions: Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material
Materials to obtain first: Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material
Further research: Material needed: Baseline tables by group, randomization/concealment, food/product blinding and assessor-handling material. This records needed materials; no new research was executed.
Remaining uncertainty: Allocation/concealment, baseline balance and actual blinding/assessor procedures remain unverified. Neither impossibility of food blinding nor absence/confirmation of bias was inferred.
Conditions for verification: Verify actual implementation/differences at the original locations, or specifically state current limits of unverified information.
Why this condition is needed: This is needed to avoid inventing complete food-intake blinding or verified protection of RCT allocation.
Application exceptions: Do not automatically judge food blinding impossible. Objective LDL-C alone does not establish absence of measurement bias.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N13 · What changes in diet, concomitant medicine and rescue treatment occurred by group?

Current findings: Participants were not using lipid-lowering medicine at baseline, and the comparison used a matched sandwich placebo. Diet, medication/rescue treatment and lifestyle changes during 6 months of follow-up, and their analytical treatment by group, are not specified in the retained summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Baseline and planned comparison content is verified, but actual accompanying changes during follow-up and differences by group remain unverified.
Reason for missing information: Do not assume there were no medication/diet changes throughout the trial or that groups remained balanced. Actual accompanying-change and target-effect handling records are needed.
Required materials and conditions: Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group
Materials to obtain first: Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group
Further research: Material needed: Baseline absence of lipid-lowering medicine, common food provision, actual diet/medication/lifestyle changes and handling by group. This records needed materials; no new research was executed.
Remaining uncertainty: Do not assume there were no medication/diet changes throughout the trial or that groups remained balanced. Actual accompanying-change and target-effect handling records are needed.
Conditions for verification: Distinguish baseline conditions from actual concomitant use/changes during follow-up and analytical effects, retaining unverified group-specific details.
Why this condition is needed: This is needed to avoid attributing other treatment/diet changes to raw-garlic LDL-C changes.
Application exceptions: Baseline absence of lipid-lowering medicine does not establish absence of all concomitant use/changes over 6 months. Do not invent change values or assume balance.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N14 · Were LDL-C methods, laboratory conditions and measurement procedures by group verified?

Current findings: The endpoint is LDL-C in mg/dL, with monthly lipid measurements during 6 months of treatment. LDL testing/calculation methods, blood-sampling/laboratory standardization and assessor-blinding details are unavailable.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Endpoint, units and measurement frequency are linked, but actual measurement conditions and procedures by group could not be verified.
Reason for missing information: Testing methods, sampling conditions, measurement error/standardization, assessment procedures and group differences remain unverified. Original values were not converted to other units.
Required materials and conditions: LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material
Materials to obtain first: LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material
Further research: Material needed: LDL-C units in mg/dL, monthly measurements, sampling/calculation methods, laboratory, blinding and standardization material. This records needed materials; no new research was executed.
Remaining uncertainty: Testing methods, sampling conditions, measurement error/standardization, assessment procedures and group differences remain unverified. Original values were not converted to other units.
Conditions for verification: Link selected LDL-C results to measurement frequency and units, stating unverified actual testing conditions and assessment procedures.
Why this condition is needed: The same LDL-C label does not establish identical testing conditions, measurement error or group differences.
Application exceptions: Do not substitute total cholesterol, TG or HDL for LDL-C or convert original values to another unit without authorization.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N15 · Are 6-month LDL-C, other lipid endpoints and prespecified outcome hierarchy distinct?

Current findings: The original reader answer and central explanation describe LDL-C as the primary (1st) endpoint; the descriptors specify 6-month change from baseline. The reasons distinguish total cholesterol, TG and HDL from LDL results. The bibliography contains an NCT identifier, but original plans were not read in this preparation.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The retained principal LDL endpoint/time point and separation from other lipids were verified. Actual comparison with prespecified registry endpoints, times and analyses remains unverified.
Reason for missing information: Original registry/protocol/SAP hierarchy, changes in plans and selection of analyses/time points remain unverified. The original primary (1st) label is not new confirmation of preregistration.
Required materials and conditions: The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables
Materials to obtain first: The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables
Further research: Material needed: The original primary (1st) LDL-C description, 6-month change, total cholesterol/TG/HDL and registry/protocol endpoint tables. This records needed materials; no new research was executed.
Remaining uncertainty: Original registry/protocol/SAP hierarchy, changes in plans and selection of analyses/time points remain unverified. The original primary (1st) label is not new confirmation of preregistration.
Conditions for verification: Link retained principal LDL-C endpoint/time point and limits on substituting other lipids, separately stating the extent of comparison with prespecified plans.
Why this condition is needed: This is needed to avoid replacing the original LDL-C result with other lipids or a favorable time point.
Application exceptions: Preserve the original primary (1st) designation, while registry/selection-reporting comparison remains unverified because originals were not read. Do not create new values for other lipids.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N16 · What changes do +0.4, +3.2, +0.2 and −3.9 represent in the four groups?

Current findings: Original 6-month changes are raw garlic +0.4, powder +3.2, AGE +0.2 and placebo −3.9 mg/dL, with a nonsignificant group-by-time result. These are changes from baseline within each group; a new direct raw-garlic versus placebo estimate was not calculated.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Values, time point, units and change definition for the four groups were attributed as originally recorded. Met concerns retention of values/analysis attribution, without establishing comparative efficacy.
Reason for missing information: The direct between-group effect, CI, exact P and variance remain separately unverified. A plus value is not positive efficacy, and placebo reduction is not a garlic effect.
Required materials and conditions: Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions
Materials to obtain first: Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions
Further research: Material needed: Original strings for 6-month raw-garlic/powder/AGE/placebo changes from baseline, the results table and analytical definitions. This records needed materials; no new research was executed.
Remaining uncertainty: The direct between-group effect, CI, exact P and variance remain separately unverified. A plus value is not positive efficacy, and placebo reduction is not a garlic effect.
Conditions for verification: Retain each group's original change, units and time point, distinguishing the nonsignificant group-by-time narrative from the unverified direct contrast.
Why this condition is needed: This is needed to avoid misreading within-group changes as between-group effects, positive efficacy or a garlic effect from placebo reduction.
Application exceptions: Do not subtract raw garlic and placebo to create a new effect estimate/CI. Do not interpret a plus sign as positive efficacy.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N17 · How do mixed modeling and partial observations relate to ITT and the target effect?

Current findings: The original reason describes retention of 87~90% and inclusion of partial observations in a mixed model. Exact ITT/PP, assignment/adherence effects, model/analysis population and missing-data sensitivity are not recorded.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The analytical narrative exists, but inclusion of partial observations was not promoted to complete ITT or verification of a particular target effect.
Reason for missing information: Analysis/target populations, fixed/repeated structures, missing-data assumptions/sensitivity and handling of departures by group remain unverified.
Required materials and conditions: The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions
Materials to obtain first: The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions
Further research: Material needed: The mixed-model description including partial observations, analysis populations, missing-data handling and assignment/adherence-effect conditions. This records needed materials; no new research was executed.
Remaining uncertainty: Analysis/target populations, fixed/repeated structures, missing-data assumptions/sensitivity and handling of departures by group remain unverified.
Conditions for verification: Retain original analytical wording and explain unverified exact populations, model, target estimate, sensitivity and departure handling.
Why this condition is needed: This is needed to avoid converting inclusion of partial data into verification of full ITT or a particular target effect.
Application exceptions: Do not infer absence of missing-data bias from retention alone or invent PP/ITT/model details.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N18 · Are the total 192 and group retention of 87~90% distinct from analysis/completion denominators?

Current findings: The 192 participants are total allocations across 4 arms; retention is recorded as a range of 87~90% by group. Allocation, analysis and completion counts for raw garlic, powder, AGE and placebo, and missingness reasons/timing, are not specifically available in the retained summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The roles of total allocation, retention range and unverified arm denominators are distinct. Counts or ITT populations were not calculated to fill gaps.
Reason for missing information: Allocation, LDL measurement/analysis and completion denominators/loss reasons by group remain unverified. There was no assumption of 48 per group, conversion of completion rates or change to ITT 192.
Required materials and conditions: Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing
Materials to obtain first: Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing
Further research: Material needed: Original total allocation of 192 and retention of 87~90%, with group allocation/analysis/completion, loss reasons and timing. This records needed materials; no new research was executed.
Remaining uncertainty: Allocation, LDL measurement/analysis and completion denominators/loss reasons by group remain unverified. There was no assumption of 48 per group, conversion of completion rates or change to ITT 192.
Conditions for verification: Retain the original overall denominator/retention range while separating unverified denominators and missingness in raw-garlic, powder, AGE and placebo arms.
Why this condition is needed: This is needed to avoid converting the displayed sample size and retention range into the actual raw-garlic analysis denominator.
Application exceptions: Do not calculate completion/analysis counts from the retention range or assume 48 per group or ITT 192.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N19 · Does a nonsignificant group-by-time result establish a precise null effect or equivalence?

Current findings: The original result says the group-by-time comparison was nonsignificant; the original reader answer says all three formulations had no statistically or clinically significant effect. A direct raw-garlic versus placebo contrast, CI and exact P are absent from the retained summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The original no-difference direction is retained, but a precise null effect, equivalence or exclusion of an important effect was not newly established. Original E0/RX are historical verdict values.
Reason for missing information: The direct raw-garlic contrast/CI, variance/exact P and equivalence/important-difference conditions remain unverified. No subtraction of within-group values or new scoring was performed.
Required materials and conditions: Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance
Materials to obtain first: Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance
Further research: Material needed: Original nonsignificant group-by-time/null wording, with raw-garlic versus placebo difference, CI, exact P and variance. This records needed materials; no new research was executed.
Remaining uncertainty: The direct raw-garlic contrast/CI, variance/exact P and equivalence/important-difference conditions remain unverified. No subtraction of within-group values or new scoring was performed.
Conditions for verification: Retain the original no-difference direction alongside unverified direct contrast/CI/exact P, without creating a new precise null effect or grade.
Why this condition is needed: This is needed to avoid automatically promoting nonsignificance or an original null assessment into proof of an effect of 0 or equivalence.
Application exceptions: Original E0/RX labels are historical verdicts, without a new precision/exclusion-interval check. A plus change within a group is not positive efficacy.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N20 · How are bibliography NCT00056511 and the evidence table's unverified registration status retained?

Current findings: The first bibliography and Korean/English research descriptions retain NCT00056511. The first evidence entry's registration status is unverified. Registration, protocol and SAP access/reading were not attempted in this preparation.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The retained identifier and structured unverified status remain distinct. Wording at different levels was not converted into plan verification, non-registration or failed access.
Reason for missing information: Preregistration timing, protocol/SAP versions, original primary endpoint/analysis/time plans and comparison with actual reporting remain unverified.
Required materials and conditions: NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material
Materials to obtain first: NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material
Further research: Material needed: NCT in the first report's bibliography and Korean research description, the first report's registration-status field, and original registration/protocol/SAP material. This records needed materials; no new research was executed.
Remaining uncertainty: Preregistration timing, protocol/SAP versions, original primary endpoint/analysis/time plans and comparison with actual reporting remain unverified.
Conditions for verification: Link both original fields separately; comparison with prespecified LDL-C, analysis and time plans remains externally unread.
Why this condition is needed: The identifier string must remain distinct from actual reading of the original registration or prespecified plans.
Application exceptions: Do not call unverified registration non-registration. An NCT string does not establish preregistration/plans or successful access.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N21 · Are Garlicin powder and Kyolic AGE arms direct replications of raw garlic?

Current findings: Within the same Gardner 4-arm report, Garlicin powder had a +3.2 and Kyolic AGE a +0.2 mg/dL 6-month change from baseline. The original central explanation says LDL-C results were null in separate analyses. These formulations differ from raw-garlic food.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Results for other formulations are retained and attributed as auxiliary comparisons within the same report. They are not independent replications of identical raw garlic or equal-dose comparisons.
Reason for missing information: Actual powder/AGE doses, processing/constituent specifications, dosing/placebo details and direct contrasts remain unverified. Raw-garlic 4-g food/placebo conditions were not transferred.
Required materials and conditions: Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details
Materials to obtain first: Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details
Further research: Material needed: Formulation-specific results and product names within the same 4-arm report, with dose, processing, active-constituent and administration details. This records needed materials; no new research was executed.
Remaining uncertainty: Actual powder/AGE doses, processing/constituent specifications, dosing/placebo details and direct contrasts remain unverified. Raw-garlic 4-g food/placebo conditions were not transferred.
Conditions for verification: Attribute powder +3.2 and AGE +0.2 mg/dL within the same report family as auxiliary comparisons of other formulations, limiting claims about raw-garlic effects and independence.
Why this condition is needed: This is needed to avoid counting no-difference results from other formulations within one report as independent replication of identical raw garlic.
Application exceptions: Powder/AGE doses remain unverified in the original material; do not transfer raw-garlic 4-g food/placebo conditions. Do not delete the other formulations' results.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N22 · What scope applies to 25 completers, 0.04 mg/dL and CI/P in the garlic-oil crossover trial?

Current findings: Berthold 1998 is a randomized, double-blind, placebo-controlled crossover trial of garlic oil with 25 completers. The original between-group LDL-C value is 0.04 mg/dL, 95% CI −9.4~9.5, P=.99, recorded as independent null evidence from another formulation. Original units/strings are retained.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The separate report's design, completion denominator and between-group value are linked. This is not replication of the same raw-garlic formulation/duration or a result from 25 initially allocated participants.
Reason for missing information: Oil specifications/dose, population, duration, allocation/analysis denominators, crossover order, washout, period and carryover handling remain unverified. No transfer to raw-garlic 6 months/4 g or unit conversion was made.
Required materials and conditions: Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration
Materials to obtain first: Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration
Further research: Material needed: Original Berthold 1998 design, 25 completers, between-group LDL-C 0.04 mg/dL/95% CI −9.4~9.5/P=.99 and oil formulation/duration. This records needed materials; no new research was executed.
Remaining uncertainty: Oil specifications/dose, population, duration, allocation/analysis denominators, crossover order, washout, period and carryover handling remain unverified. No transfer to raw-garlic 6 months/4 g or unit conversion was made.
Conditions for verification: Link the separate report, crossover design, 25 completers and attribution of original between-group values, without transfer to raw-garlic formulation, duration or denominators.
Why this condition is needed: This is needed to avoid treating a separate oil result as raw-garlic food, direct 6-month replication or an allocation result for all 25.
Application exceptions: Preserve original mg/dL, CI and P without unrequested correction/conversion because of suspected units. Retain unverified oil dose, duration, population, sequence, washout and carryover handling.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S2

N23 · What status applies to older positive high-dose AGE/powder narratives and a separate powder-trial mention?

Current findings: Korean/English counterviews describe LDL reductions in some older high-dose AGE/powder trials; the research description mentions independent oil and powder placebo trials. Only Gardner and Berthold pairs are explicitly present in current evidence/bibliographies.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Original positive/opposing background narratives remain, but unidentified high-dose AGE/powder reports or a separate powder trial were not created as new reports.
Reason for missing information: Names/identifiers, products/doses, denominators, estimates/CIs and access material for these background reports remain unverified. Differences in formulations are not automatically conflicting data for the same question.
Required materials and conditions: Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material
Materials to obtain first: Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material
Further research: Material needed: Original Korean/English counterview and research narratives, with identifiable reports, products, doses, population and endpoint material. This records needed materials; no new research was executed.
Remaining uncertainty: Names/identifiers, products/doses, denominators, estimates/CIs and access material for these background reports remain unverified. Differences in formulations are not automatically conflicting data for the same question.
Conditions for verification: Link the existence of background narratives to unverified identity/values/access, without automatically labeling different questions as conflicting data.
Why this condition is needed: This is needed to preserve formulation/design differences between positive background and the current direct no-difference result without inventing unverified reports.
Application exceptions: There are currently 2 evidence entries/bibliographies. Unidentified positive AGE/powder or independent-powder-trial narratives must not generate S3, a new bibliography or independent-replication counts.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N24 · Were clinical-importance and precision criteria for the between-group LDL-C effect verified?

Current findings: The retained summary does not establish a direct raw-garlic versus placebo effect/CI or an LDL-C important-difference threshold. Original D30, nonsignificance, the total 192 and the oil CI for another formulation do not replace raw-garlic precision/clinical-importance conditions.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Original material for comparing the selected raw-garlic reported interval against a justified clinical criterion is unavailable. No new judgment about permitted/excluded important effects was made.
Reason for missing information: The raw-garlic contrast/CI, variance and justified MID/equivalence threshold remain unverified. No arbitrary participant, duration or threshold criteria or new calculation were introduced.
Required materials and conditions: Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators
Materials to obtain first: Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators
Further research: Material needed: Original raw-garlic versus placebo effect/CI, criteria/important difference, units, variance and denominators. This records needed materials; no new research was executed.
Remaining uncertainty: The raw-garlic contrast/CI, variance and justified MID/equivalence threshold remain unverified. No arbitrary participant, duration or threshold criteria or new calculation were introduced.
Conditions for verification: Distinguish availability of a selected raw-garlic CI and a justified importance criterion; if unavailable, explain that the range of important effects cannot be interpreted.
Why this condition is needed: 192 participants, nonsignificance and original D30 alone cannot establish precision or exclusion of an important effect.
Application exceptions: Do not invent a minimum sample size, duration, MID, equivalence threshold or new score. Do not apply the oil CI to raw-garlic precision.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N25 · Does the record answer other doses, subgroups and persistence after treatment?

Current findings: The selected raw-garlic scope is about 4 g on 6 days weekly for 6 months. The retained summary has no direct raw-garlic dose comparison, prespecified effect-modification/subgroup estimate or post-discontinuation persistence value. Other formulations are not raw-garlic dose-response comparisons.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Direct information for extended questions could not be established within the retained material. Every extension trial was not made mandatory for the narrow original claim.
Reason for missing information: Direct estimates for an optimal amount, other raw-garlic doses/durations, specific responder groups or persistence after stopping remain unverified. This does not establish absence of external research.
Required materials and conditions: Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months
Materials to obtain first: Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months
Further research: Material needed: Direct dose comparisons, prespecified subgroup/interaction and post-treatment follow-up material beyond the stated 4 g on 6 days weekly for 6 months. This records needed materials; no new research was executed.
Remaining uncertainty: Direct estimates for an optimal amount, other raw-garlic doses/durations, specific responder groups or persistence after stopping remain unverified. This does not establish absence of external research.
Conditions for verification: Limit the current direct scope and separately retain unverified extended questions and their estimates.
Why this condition is needed: This is needed to avoid extending an LDL-C result for one food amount/duration to an optimal dose, responder group or persistence effect.
Application exceptions: Do not require every extension trial to satisfy the narrow original main claim. An optimal amount, minimum duration and subgroup results absent from the original material remain unverified.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N26 · Does the LDL-C question answer cardiovascular-event prevention or replacement of statins?

Current findings: The original verdict selects 6-month LDL-C only and prohibits claims that one clove acts like a statin or use of pooled values from other formulations. Direct cardiovascular-event, death/quality-of-life or statin-replacement results are absent from the retained summary.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The LDL-C question is distinct from event/standard-treatment replacement questions. Met concerns limits on interpretation, without establishing event effects.
Reason for missing information: Direct event/standard-treatment comparisons remain unverified within the retained material. No new claim was made that the entire original paper did not test or report them.
Required materials and conditions: The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material
Materials to obtain first: The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material
Further research: Material needed: The original LDL-C endpoint and direct clinical-event, quality-of-life, death and standard-treatment comparison material. This records needed materials; no new research was executed.
Remaining uncertainty: Direct event/standard-treatment comparisons remain unverified within the retained material. No new claim was made that the entire original paper did not test or report them.
Conditions for verification: Distinguish the direct LDL-C scope from separate clinical questions, retaining original statin-advertising limits and unverified direct event material.
Why this condition is needed: This is needed to avoid transferring retained lipid results to cardiovascular events or replacement of standard treatment.
Application exceptions: Do not require an event trial for the LDL-C-change question, but do not claim verified event/replacement effects.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N27 · Are gastrointestinal, odor and allergy cautions observed events in the trial?

Current findings: The original caution mentions possible gastrointestinal symptoms, odor and allergy from raw garlic, plus bleeding-risk review with high intake and anticoagulant/antiplatelet use. Event counts, collection/severity and group denominators in the trial are absent from the retained summary.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The general original caution is verified, but trial-specific observation, causality and incidence were not established.
Reason for missing information: Harm-event definitions, collection methods, individual occurrence, severity/discontinuation and denominators remain unverified. Absence from the retained summary does not establish non-reporting in the whole external paper or 0 adverse effects.
Required materials and conditions: Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables
Materials to obtain first: Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables
Further research: Material needed: Original caution/safety wording, individual-event definitions, collection/severity, group denominators and adverse-event tables. This records needed materials; no new research was executed.
Remaining uncertainty: Harm-event definitions, collection methods, individual occurrence, severity/discontinuation and denominators remain unverified. Absence from the retained summary does not establish non-reporting in the whole external paper or 0 adverse effects.
Conditions for verification: Separate a general caution from unverified trial-specific event counts, collection and causality; do not delete efficacy observations because of harm results.
Why this condition is needed: This is needed to avoid promoting general cautions into trial-observed event counts, causes or safety assessments.
Application exceptions: The lack of individual-harm results in the retained text must not be extended to non-reporting in the whole external paper or 0 adverse effects.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N28 · Was the timeline of harm onset, stopping, recovery and re-exposure verified?

Current findings: 6 months of raw-garlic efficacy treatment are recorded, but the original caution has no individual timeline of harm onset, latency, recovery, discontinuation or re-exposure.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: General cautions and treatment duration alone cannot establish individual-event temporal ordering or causality.
Reason for missing information: Event-specific timing, exposure changes, recovery after stopping, re-exposure and follow-up remain unverified. No cases were invented and temporal ordering was not treated as causation.
Required materials and conditions: Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records
Materials to obtain first: Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records
Further research: Material needed: Actual raw-garlic exposure, harm onset/recovery, discontinuation/re-exposure, latency and follow-up records. This records needed materials; no new research was executed.
Remaining uncertainty: Event-specific timing, exposure changes, recovery after stopping, re-exposure and follow-up remain unverified. No cases were invented and temporal ordering was not treated as causation.
Conditions for verification: Distinguish exposure duration from individual-event timing, retaining unverified status when actual records are unavailable.
Why this condition is needed: This is needed to avoid treating 6-month exposure as the onset time or cause of individual symptoms.
Application exceptions: The original general caution has no individual timeline. Do not infer improvement after stopping, positive re-exposure or latency.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N29 · Were harm controls, affected people, exposure denominators and follow-up verified?

Current findings: Efficacy information includes a 4-arm raw-garlic versus food-placebo design with 192 total allocations, and 25 completers for auxiliary oil. The retained summary has no harm people/event counts by group, harm-exposure denominators/follow-up or reported between-group harm estimate.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Efficacy controls/sample sizes are distinguished from harm-specific comparisons and denominators. Warnings alone do not permit calculation of frequency or increased risk.
Reason for missing information: Harm-specific controls, events/affected people, exposure/follow-up denominators and time remain unverified. Neither 192 nor 25 was transferred to a harm denominator, and background incidence was not extrapolated.
Required materials and conditions: Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material
Materials to obtain first: Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material
Further research: Material needed: Actual harm people/event counts by group, exposure/observation denominators, duration and comparison/follow-up material. This records needed materials; no new research was executed.
Remaining uncertainty: Harm-specific controls, events/affected people, exposure/follow-up denominators and time remain unverified. Neither 192 nor 25 was transferred to a harm denominator, and background incidence was not extrapolated.
Conditions for verification: Link the verified extent of harm-specific controls, events and exposure denominators/follow-up without inventing comparative estimates as original values.
Why this condition is needed: This is needed to avoid using the efficacy 4-arm placebo, 192 allocations or 25 oil completers as denominators for harm frequency/risk ratios.
Application exceptions: Do not fill proportions, RR or background incidence from general warnings without harm events/denominators. An efficacy control is distinct from a verified harm comparison.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N30 · What are the high-intake, anticoagulant/antiplatelet cautions and alternative causes?

Current findings: The original text cautions about bleeding-risk review with high intake and anticoagulant/antiplatelet use. Raw-garlic baseline conditions exclude lipid-lowering medicine, but anticoagulant/antiplatelet co-use, events and a numerical high-intake threshold are unavailable.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The co-use caution is verified, but this does not establish observed co-use bleeding or confirmed interaction in the raw-garlic 4-g trial.
Reason for missing information: Actual co-medication/baseline risk, events/timing, alternative causes and high-intake thresholds remain unverified. Absence of lipid-lowering medicine was not converted to absence of other medicine.
Required materials and conditions: Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material
Materials to obtain first: Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material
Further research: Material needed: Original high-intake/co-use bleeding caution and actual co-medication, baseline risk, exposure amount, events and alternative-cause material. This records needed materials; no new research was executed.
Remaining uncertainty: Actual co-medication/baseline risk, events/timing, alternative causes and high-intake thresholds remain unverified. Absence of lipid-lowering medicine was not converted to absence of other medicine.
Conditions for verification: Distinguish original co-use cautions from unverified actual simultaneous exposure, alternatives and group risks, without personal dosing instructions or a new safety judgment.
Why this condition is needed: This is needed to avoid converting caution wording into proof of co-use bleeding or a dose threshold in this raw-garlic 4-g trial.
Application exceptions: A numerical high-intake threshold, co-use events and baseline-risk balance remain unverified. Absence of lipid-lowering medicine does not mean no anticoagulant/antiplatelet use.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N31 · Are retention/efficacy missingness distinct from harm detection and reporting losses?

Current findings: Original retention of 87~90% and the mixed model including partial observations concern LDL efficacy follow-up. Harm collection/detection, events in dropouts, discontinuation reasons and disclosure of all harms are not specified in the retained summary.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Efficacy missing-data handling cannot verify complete harm follow-up or absence of harm. Losses were not treated as evidence of harm occurrence.
Reason for missing information: Harm-collection systems, differences in detection/spontaneous reporting, reasons for non-follow-up/discontinuation/dropout and full disclosure scope remain unverified.
Required materials and conditions: Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material
Materials to obtain first: Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material
Further research: Material needed: Original retention of 87~90% and mixed modeling, with actual harm collection/loss, discontinuation/detection and disclosure-scope material. This records needed materials; no new research was executed.
Remaining uncertainty: Harm-collection systems, differences in detection/spontaneous reporting, reasons for non-follow-up/discontinuation/dropout and full disclosure scope remain unverified.
Conditions for verification: Separate efficacy follow-up from verification of harm collection/reporting, retaining possible selection/detection limitations as unverified.
Why this condition is needed: Efficacy retention/inclusion of partial observations alone cannot verify that all harms were followed and counted.
Application exceptions: Do not conversely infer harms occurred because of losses. Distinguish absence from the original summary from non-reporting in the entire paper.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N32 · Were independent cases and report families for the same harm verified?

Current findings: The original material contains Korean/English/synthesis restatements of general cautions and two LDL reports. Identities of unique harm cases, related reports and re-citation families with matching exposure/events are not recorded.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Two efficacy reports and original RX/I2 cannot be transferred to independent-harm replication counts. Original cautions remain and unique harm counts stay unverified.
Reason for missing information: Unique harm cases/families, independent studies, related registrations and re-citation links remain unverified. This does not claim their absence from all original papers or regulatory material.
Required materials and conditions: Original material linking unique cases/studies and related reports/re-citations with matching exposures and events
Materials to obtain first: Original material linking unique cases/studies and related reports/re-citations with matching exposures and events
Further research: Material needed: Original material linking unique cases/studies and related reports/re-citations with matching exposures and events. This records needed materials; no new research was executed.
Remaining uncertainty: Unique harm cases/families, independent studies, related registrations and re-citation links remain unverified. This does not claim their absence from all original papers or regulatory material.
Conditions for verification: Link verified original cautions to unverified actual independent-harm material, retaining unknown case/participant/replication counts as unverified.
Why this condition is needed: This is needed to avoid counting repeated general cautions, two LDL reports or Korean/English/synthesis restatements as independent harm replication.
Application exceptions: The current material lacks unique harm-case/related-registration identity. Do not transfer original efficacy RX/I2 or the 2 reports to harm independence.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N33 · What is known about long-term/rare harms and vulnerable groups beyond 6-month LDL observation?

Current findings: The selected raw-garlic scope concerns age 30~65, the stated LDL range and 6-month LDL-C, with general cautions. Direct results beyond this scope for long-term/rare harms, other baseline risks, vulnerable groups and combined exposures are not established in the retained summary.
Verification status: Unverified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: A restricted efficacy population/duration differs from overall safety. Every long-term/rare-event trial was not made a required condition for this LDL claim.
Reason for missing information: Direct long-term/rare-event and special-population exposure/interaction material remains unverified. No arbitrary minimum duration/sample size or overall harmlessness conclusion was introduced.
Required materials and conditions: Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material
Materials to obtain first: Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material
Further research: Material needed: Original general cautions and direct long-term/rare-event, other baseline-risk/age, special-exposure and co-use material. This records needed materials; no new research was executed.
Remaining uncertainty: Direct long-term/rare-event and special-population exposure/interaction material remains unverified. No arbitrary minimum duration/sample size or overall harmlessness conclusion was introduced.
Conditions for verification: Distinguish stated population/duration from unverified direct information for separate long-term/vulnerable-group harm questions.
Why this condition is needed: This is needed to avoid generalizing a limited population and 6-month lipid result to overall safety.
Application exceptions: Do not require every rare-harm study for the current LDL question or invent a minimum follow-up duration or sample size.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1

N34 · What can current material say about harm, harmlessness and causality?

Current findings: Current verified scope consists of original general cautions and LDL results limited by formulation, duration and denominators. Trial-specific harm counts, controls, denominators, timing and alternative-cause material are unavailable, so incidence, causality and harmlessness were not newly judged.
Verification status: Partly verified
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: Caution level is distinct from unverified harm. No-difference efficacy and harm-verification status were not merged.
Reason for missing information: Trial-specific harm collection/comparison/denominators, causality and long-term safety remain unverified. No personal dosing/stopping instruction or safety grade was created.
Required materials and conditions: Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material
Materials to obtain first: Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material
Further research: Material needed: Original cautions/warnings and event definitions/controls, denominators, timing, alternatives and collection material. This records needed materials; no new research was executed.
Remaining uncertainty: Trial-specific harm collection/comparison/denominators, causality and long-term safety remain unverified. No personal dosing/stopping instruction or safety grade was created.
Conditions for verification: State the extent of caution, unverified trial-specific harms and inability to create new causality/incidence estimates.
Why this condition is needed: This is needed to avoid turning no-difference efficacy and general cautions into harmlessness, confirmed causality or a new safety grade.
Application exceptions: Preserve cautions without personal dosing/stopping instructions or clinical certification. Unverified harms must not erase the LDL result itself.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2

N35 · Were original D30, RX/E0/I2/B1/C0, Korean/English wording, corrections and native values retained as historical text?

Current findings: Original D, integer 30, all axes RX/I2/E0/B1/C0, false/empty strings, Korean/English verdict-decision and synthesis text, corrections, verdict date, empty subclaims and original URLs are retained through a whole typed original-record anchor. Current condition states remain distinct from historical verdict/access narratives.
Verification status: Met
Materials actually read: The retained Korean/English summaries and case-specific conditions/application records were read. Linked external abstracts, full texts, registration and planning material remain unread, with no access attempt.
Why unverified: The complete current original/native types, values and events are retained, without transfer to a new score/grade, independent clinical certification or full-text reading.
Reason for missing information: Unavailable original access levels or evidence cutoffs were not inferred. This preparation involved no new clinical material, recalculation, reassessment or original-text correction.
Required materials and conditions: The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks
Materials to obtain first: The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks
Further research: Material needed: The complete current original, score/axes, Korean/English verdict-decision/synthesis, empty values/dates and corrections, with typed original text/source-identity checks. This records needed materials; no new research was executed.
Remaining uncertainty: Unavailable original access levels or evidence cutoffs were not inferred. This preparation involved no new clinical material, recalculation, reassessment or original-text correction.
Conditions for verification: Preserve the whole typed original and historical dates/values while distinguishing current observations, states, access and review.
Why this condition is needed: This is needed to prevent original score, replication, null and independence labels from being inherited as new condition fulfillment, current full-text reading or precision certification.
Application exceptions: The original score is integer 30; subclaims remain empty, and false/empty strings and corrections retain their native types. No new grade, calculation or translation correction was performed.
Referenced methods: Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.

Related sources S1 S2