Medical-grade manuka honey × MGD dry-eye signs: formulation-specific staining and meibomian signals

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich signs question does this evidence check cover?Required	The existing selected question is improvement in selected staining or meibomian signs. The original account of formulation-specific signals from a small open multiple-outcome trial is retained. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Formulation-specific comparisons for improvement in selected staining and meibomian signs	Material needed: Selected findings are not expanded into all signs or symptom effects. Original formulation, sign, control and time-specific tables, denominators and CIs require additional material. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionWhat does the staining signal with 16% drops represent?Required	The principal trial records staining with drops P=.035 as a selected between-group signal. Exact staining effects, scales and CIs are absent from the stored summary. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Staining measurement with drops, between-group estimates, P values and CIs	Material needed: Original staining sites, scales, assessors, time points, groups, denominators, effects and CIs remain unverified. The value is not converted into a symptom or gel result. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat is the meibum quality signal with 98% gel?Required	The original principal trial records gel meibum quality P=.005. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The definition, assessment, between-group effect, P values and CIs for gel meibum quality	Material needed: The same value is not copied to staining, gland expressibility or all signs. Grades, scales, assessment, expression methods, groups, denominators, time points, effects and CIs remain unverified. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionWhat is the gland expressibility signal with 98% gel?Required	The original principal trial records gel gland expressibility P=.042. It is retained as a separate sign from meibum quality. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Gland expressibility scales, measurement, between-group effects, P values and CIs	Material needed: Gland selection, measurement, grades, assessors, groups, time points, denominators, effects and CIs remain unverified. New differences are not calculated. This records needed materials; no new research was executed.
5	Unverified	Full text not readStored summary read	N05 · Evidence conditionHow do P values differ from effect size and precision?Required	The stored summary provides selected P values but does not retain exact formulation-specific effect sizes and intervals. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Sign-specific between-group estimates, variance and 95% CIs	Material needed: P values alone do not newly verify large effects, precision, cure or equivalence. Original formulation-specific estimates, baseline and changes, denominators, variance, CIs and models remain unverified. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionAre improvement in all groups and added sign effects distinguished?Required	Improvement in all groups is the common-care context. Selected between-group sign signals and before-and-after improvement within each group are retained separately. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Direct comparison conditions for each formulation and sign versus common care	Material needed: Overall recovery is not assigned to honey as an ingredient. Common care, formulation-specific baselines, time points, all results and between-group contrast tables remain unverified. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionCan drops, gel, staining and gland measures be interchanged?Required	The original account distinguishes staining with drops from meibomian measures with gel. The 3 P values link to different formulations and measures. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Matching 16% drop staining to 98% gel quality and expressibility	Material needed: They are not pooled into a combined effect for one product or scale. Formulations, administration, scales, time points, group denominators and direct superiority comparisons remain unverified; formulation equivalence or superiority is not established. This records needed materials; no new research was executed.
8	Unverified	Full text not readStored summary read	N08 · Evidence conditionAre assessors and reproducibility of staining and meibum measurement verified?Required	The original outcome list includes staining and meibum, but methods, scales, assessors and agreement are not detailed. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Original measurement, expression, assessment sites, scales and masking methods	Material needed: Successful assessor masking is not newly added to an open trial. Tests, scales, sites, gland selection, assessors, photographs, video, measurement records and time points remain unverified. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionHow do the open 3-group design, multiple outcomes and selected signals relate?Required	The original selected explanation and principal report retain the limitation of a small open multiple-outcome trial. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Prespecified primary outcomes, multiple signs and time points, and multiplicity plans	Material needed: Selected positive P values do not establish prespecified primary-outcome success or positive findings for all outcomes. Registration, protocols, analysis plans, all result tables and multiplicity remain unverified; no new official risk assessment is created. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionDoes the supporting trial's signs list also provide exact effects?Required	The supporting trial's outcomes are 3-week SPEED, tear film, inflammation and staining. The stored result values are within-group SPEED changes. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Tear-film, inflammation and staining results from the 59-participant trial	Material needed: SPEED values or P values are not copied into sign results. Original sign-specific results, time points, denominators, formulation, hierarchy, between-group effects and CIs remain unverified. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionAre symptom superiority and sign signals different questions?Supplementary	The parent and symptom question retain a gap in direct between-group symptom effects. Selected sign signals do not become symptom verification or new independent trials. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The boundary of direct results for selected signs and the symptom question	Material needed: Original symptom and sign tables, denominators, scales and matching within the same cohort remain unverified. Shared reports across the questions are not counted as separate independent replication. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionDo tear film, colonization and lubricant use share the same effect?Supplementary	The principal trial's outcome list also includes tear film, colonization and lubricant use. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Separate outcomes for other ocular-surface measures, mechanisms and medication use	Material needed: The selected 3 P values are not used as effects on remaining outcomes, clinical symptoms or infection prevention. Each original outcome, hierarchy, value, denominator and between-group contrast remains unverified; unrecorded effects or CIs are not created. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionHow are the principal 8 weeks, supporting 3 weeks and long-term recovery distinguished?Supplementary	The original principal direct trial spans 8 weeks and the supporting trial 3 weeks. Durations from different reports are distinguished. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Sign-specific time points, exposure, post-stopping and long-term follow-up	Material needed: Sign signals are not expanded into permanent gland recovery or long-term durability. Report-specific sign time points, administration, long-term and post-stopping course and direct results remain unverified. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionHow are medical-grade sterile products distinguished from food honey?Required	The original record concerns ophthalmic medical-grade products, not evidence for food-grade manuka honey or homemade dilution. Concentration differs from actual instilled amount and frequency. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel	Material needed: Product, sterility, ingredients, manufacture, dose, frequency and administration records remain unverified in detail. Medical-grade product records are not expanded into effects of food-grade or nonsterile products. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWhat was added to common lid care?Required	In 2017, all groups used common warm compresses, lid massage and preservative-free lubricant. The comparison added medical-grade honey products to that care. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Warm compresses, massage, preservative-free lubricant and formulation-specific additional care	Material needed: It is not converted into evidence for stopping care or standalone treatment. Common-care rules, adherence, additional and rescue medications, formulation-specific matching and changes remain unverified. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionAre MGD diagnosis and sample size the same information?Required	The parent question concerns evaporative dry eye from meibomian gland dysfunction. 114 participants is the original sample-size label. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye	Material needed: Sample size does not replace diagnostic or eligibility criteria. Diagnosis, severity, baseline symptoms and signs, age, comorbidities and group-specific inclusion and exclusion remain unverified. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWhat are the selected-sign denominators in 114 participants and 3 groups?Required	The principal trial's sample was 114 participants and its design was an open 3-group randomized trial. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Group allocation, completion, analysis and endpoint-specific eye and patient denominators	Material needed: Group allocation, completion, formulations, care groups, endpoints, time points, bilateral-eye and patient denominators and exclusions remain unverified. Denominators absent from the original are not created. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionWhat denominators are 59 randomized and 55 completed?Required	The supporting trial originally recorded 59 randomized and 55 completed. These values describe separate stages. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators	Material needed: Attrition counts or group-specific and endpoint-specific analysis denominators are not calculated or established. Group flow, reasons, time points and eye and patient denominators remain unverified. This records needed materials; no new research was executed.
19	Unverified	Full text not readStored summary read	N19 · Evidence conditionWhat is the impact of missingness, attrition and measurement exclusions?Required	Overall sample and completion records exist, but endpoint-specific missingness, attrition reasons and analysis conditions are not detailed. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses	Material needed: Unread external material is not converted into absence of missingness. Missingness, stopping, exclusions, ITT and completer analyses, missing-data handling, sensitivity and group and eye matching remain unverified. This records needed materials; no new research was executed.
20	Unverified	Full text not readStored summary read	N20 · Evidence conditionWhat were the baseline adjustment, change and testing conditions?Required	Original P values and selected changes are retained, but detailed adjustment, variance, time points, denominators and effects of interest remain unread in external originals. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The effect of interest, baseline adjustment, change and final values, and variance	Material needed: Original analysis plans, statistical tables, baseline and changes, within-eye and within-person correlation, models and CIs remain unverified. New effects or CIs are not back-calculated. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionDoes a registration number also verify prespecified plans?Required	Registration was unverified for the principal trial, while NCT04457648 was recorded for the supporting trial. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Registration, history, primary outcomes, changes and original plans for both trials	Material needed: The number's existence is not promoted into registration reading in this work, prespecification, hierarchy at all time points or plan adherence. Official registration history, protocols and analysis plans were unread in this work. This records needed materials; no new research was executed.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionDo parent and subquestions share the same reports?Required	The parent and subquestions share the same Albietz 2017 and Wong 2021 reports. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Report, trial and participant links between the symptom question and other questions	Material needed: Sheet counts are not counted as new studies or independent replications. Report, trial, registration, sample, institution, timing and additional-report matching and unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionIs independent replication across teams, products and formulations verified?Supplementary	The bibliographies of both reports retain an Albietz author and the specific Optimel product context. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point	Material needed: Different reports or assessor masking alone do not newly establish independent teams or replication under the same conditions. Team, institution, product, funding, participant, effect and denominator matching remain unverified. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionHow much is known about product provision and company involvement?Required	The principal trial records Optimel product provision and related involvement; the supporting trial records a specific Optimel product, provision and author conflict disclosure. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Trial-specific funding, product support, employee authors and conflicts	Material needed: Unrecorded funding, employee relationships, analysis and publication roles remain unverified. Product provision is not treated as verification of every involvement route or as absence of independence. This records needed materials; no new research was executed.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionWhat is the scope of reported stinging and redness?Supplementary	The original record reports temporary stinging and redness and cautions that initial symptoms are possible even with medical-grade formulations. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Medical-grade product adverse reactions, collection methods, stopping and controls	Material needed: Event counts, incidence or new causality are not created. Collection methods, group and formulation-specific events, severity, timing, stopping, missingness and controls remain unverified. This records needed materials; no new research was executed.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionWhat are the eye and patient harm denominators and exposures?Supplementary	114 participants, 59 randomized and 55 completed do not verify safety denominators. Concentrations, formulations, 3 and 8 weeks and common care are not combined as the same harm exposure. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Safety populations, eyes, patients, formulations, durations and actual instillation exposure	Material needed: Safety denominators, actual instillation, group, eye and formulation-specific events, stopping, exposure and controls remain unverified. Incidence is not calculated. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionAre food or nonsterile risks distinguished from medical-grade product reactions?Supplementary	The original caution distinguishes infection and corneal-injury risks with food-grade, nonsterile and homemade dilutions from initial stinging and redness with medical-grade products. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Manufacture, sterility, baseline eye conditions, other causes and clinical course	Material needed: The food-honey self-instillation question is distinguished and no new case is created. Products, baseline eye conditions, concurrent use, event timing, alternative causes, controls and course remain unverified; no new harm causality is judged. This records needed materials; no new research was executed.
28	Unverified	Full text not readStored summary read	N28 · Evidence conditionAre long-term, rare and vulnerable-population harms verified?Supplementary	Small short-term trials of specific products and descriptions of temporary reactions do not verify long-term, rare or vulnerable-population safety. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	Long exposure, independent harm reports, vulnerable populations and follow-up	Material needed: Long follow-up, independent harm reports, vulnerable populations, exposure, denominators, concurrent use and course remain unverified. No external search or new harm judgment was performed in this work. This records needed materials; no new research was executed.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionHow does stored-summary reading differ from reading external originals?Required	The complete parent Korean and English summary, reports and citations were read. PubMed URLs and registration numbers are existing records; external abstracts, full texts, registration, protocols and analysis plans were unread in this work. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The complete stored summary and the reading scope for external abstracts, full texts, registration and plans	Material needed: URLs, numbers and historical verification wording do not establish current reading, successful access or fulfilled conditions. External detailed-material availability, acquisition and actual reading remain separately unverified. This records needed materials; no new research was executed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionWhat do selected C, parent C46, dates and empty values record?Required	The selected grade is C, with no individual score, status or axes fields. Parent C46, caution, axes, Korean and English records, 2026-09-07 and empty correction and deliberation records are preserved separately. R01 R02	This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.	The selected grade, absent individual score, parent axes, evidence date and corrections	Material needed: The parent's 46 points are not assigned as a subclaim score, and the historical evidence date is not changed into a new search, external reading or completed-review date. New material, condition revisions and verdict changes are separate events. This records needed materials; no new research was executed.

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30 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Evaporative dry eye from meibomian gland dysfunction. Detailed diagnosis, severity, baseline status, eligibility and group composition remain unverified.
Ingredient, formulation and route: Medical-grade 16% manuka-honey drops or 98% gel were added to existing lid care. Formulations are distinguished from each other and from food-grade or nonsterile products.
Dose: 16% and 98% are concentrations of different formulations. Actual instilled amount, frequency, adherence and exposure remain unverified; concentration is not converted into administered dose.
Comparator: Common warm compresses, lid massage and preservative-free lubricant in the 2017 trial are distinguished from comparison with regular lubricant in the 2021 trial. Details of matched group care and changes remain unverified.
Measured outcome: Staining with 16% drops P=.035 and meibum quality P=.005 and gland expressibility P=.042 with 98% gel are distinguished by formulation and sign. Supporting-trial within-group SPEED results are not sign estimates.
Duration: The principal direct trial over 8 weeks is distinguished from the supporting trial over 3 weeks. Sign signals are not converted into permanent gland recovery or long-term effects; post-stopping durability and long-term harms remain unverified.
Questions outside this scope: Selected-signs C and absent individual score are distinguished from parent C46, symptom C and food-honey self-instillation F. Parent score or axes are not newly inherited.; 16% drops and 98% gel are not combined, and medical-grade sterile products are not expanded into evidence for food-grade, nonsterile or homemade-dilution instillation.; Staining P=.035, meibum quality P=.005 and gland expressibility P=.042 are selected signals linked to their respective formulations and signs. They are not combined into one formulation, scale or overall effect.; SPEED 2.53 points P=.006 and 1.087 points P=.183 are within-group symptom records from the supporting trial. They are not converted into sign estimates, direct between-group symptom effects, new differences or CIs.; 114 participants and 59 randomized with 55 completed are distinguished without calculating new attrition counts, group, eye, patient or safety denominators, or incidence.; Shared reports are not counted as new independent replication for each question. Short-term symptoms and signs are not expanded into long-term recovery, treatment replacement or overall safety.

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Albietz JM·Lenton LM. 2017

PubMed

Material type: Open 3-group randomized trial
Materials actually read: The complete stored parent Korean and English summary, original reports and citations were read. External abstracts, full texts, registration, protocols and analysis plans were unread in this work.
Findings recorded in the stored summary: The original comparison in 114 participants added 16% drops or 98% gel to common care. All groups improved; selected sign signals included staining with drops P=.035 and gel meibum quality P=.005 and gland expressibility P=.042.
Record level: These are selected formulation-specific sign signals from the principal open multiple-outcome trial. The original principal duration is 8 weeks; exact sign effects, CIs, scales, measurement, eye and patient denominators and prespecified hierarchy remain unverified. Symptom superiority, formulation superiority and permanent gland recovery are not established.
Study overlap and independent replication: Parent 3016 and the symptom and selected-sign questions share 2 reports, Albietz 2017 and Wong 2021. Shared authors and the specific Optimel product context are retained, while exact sample overlap, unique trial and participant totals and independent replication remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID28585260, DOI10.1111/cxo.12524 and the original record of Optimel product provision and related involvement are retained. Registration details, product contracts, funding and author roles are unread externally; unverified information is not converted into absence. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID28585260, DOI10.1111/cxo.12524 and the original record of Optimel product provision and related involvement are retained. Registration details, product contracts, funding and author roles are unread externally; unverified information is not converted into absence. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID28585260, DOI10.1111/cxo.12524 and the original record of Optimel product provision and related involvement are retained. Registration details, product contracts, funding and author roles are unread externally; unverified information is not converted into absence. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID28585260, DOI10.1111/cxo.12524 and the original record of Optimel product provision and related involvement are retained. Registration details, product contracts, funding and author roles are unread externally; unverified information is not converted into absence. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID28585260, DOI10.1111/cxo.12524 and the original record of Optimel product provision and related involvement are retained. Registration details, product contracts, funding and author roles are unread externally; unverified information is not converted into absence. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.

R02 · Wong D et al. 2021

PubMed

Material type: Assessor-masked randomized trial
Materials actually read: The complete stored parent Korean and English summary, original reports and citations were read. External abstracts, full texts, registration, protocols and analysis plans were unread in this work.
Findings recorded in the stored summary: 59 randomized and 55 completed were recorded, with 3-week within-group SPEED changes of 2.53 points P=.006 for honey drops and 1.087 points P=.183 for regular lubricant. The stored summary states that the abstract did not present a direct between-group symptom effect.
Record level: Tear film, inflammation and staining appear in the supporting trial outcome list, but the original numeric results are within-group SPEED changes. They are not converted into sign effects or direct between-group symptom effects. Assessor masking is not promoted into participant or treatment-provider masking, and new differences, CIs, attrition counts or safety denominators are not calculated.
Study overlap and independent replication: Parent 3016 and the symptom and selected-sign questions share 2 reports, Albietz 2017 and Wong 2021. Shared authors and the specific Optimel product context are retained, while exact sample overlap, unique trial and participant totals and independent replication remain unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Stored summary	Summary read	PMID33419788, DOI10.1136/bjophthalmol-2020-317506, NCT04457648, specific Optimel product provision and author conflict disclosure are retained. The number does not establish registration reading in this work, prespecification or plan adherence; disclosure details are unread. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
External abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33419788, DOI10.1136/bjophthalmol-2020-317506, NCT04457648, specific Optimel product provision and author conflict disclosure are retained. The number does not establish registration reading in this work, prespecification or plan adherence; disclosure details are unread. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
External full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33419788, DOI10.1136/bjophthalmol-2020-317506, NCT04457648, specific Optimel product provision and author conflict disclosure are retained. The number does not establish registration reading in this work, prespecification or plan adherence; disclosure details are unread. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
Registration material	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33419788, DOI10.1136/bjophthalmol-2020-317506, NCT04457648, specific Optimel product provision and author conflict disclosure are retained. The number does not establish registration reading in this work, prespecification or plan adherence; disclosure details are unread. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.
Protocol and analysis plan	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	PMID33419788, DOI10.1136/bjophthalmol-2020-317506, NCT04457648, specific Optimel product provision and author conflict disclosure are retained. The number does not establish registration reading in this work, prespecification or plan adherence; disclosure details are unread. The stored-summary material date 2026-10-06T13:02:14.262787+09:00 is an original production record; unread external material dates are empty. The historical evidence date 2026-09-07 is distinguished from this publication, external reading or completed clinical review.

Report counts versus independent study counts

Parent 3016 and the symptom and selected-sign questions share 2 reports, Albietz 2017 and Wong 2021. Shared authors and the specific Optimel product context are retained, while exact sample overlap, unique trial and participant totals and independent replication remain unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which signs question does this evidence check cover?

Required materials and conditions: Formulation-specific comparisons for improvement in selected staining and meibomian signs
Conditions for verification: Original material on Formulation-specific comparisons for improvement in selected staining and meibomian signs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Formulation-specific comparisons for improvement in selected staining and meibomian signs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N02 · What does the staining signal with 16% drops represent?

Required materials and conditions: Staining measurement with drops, between-group estimates, P values and CIs
Conditions for verification: Original material on Staining measurement with drops, between-group estimates, P values and CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Staining measurement with drops, between-group estimates, P values and CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N03 · What is the meibum quality signal with 98% gel?

Required materials and conditions: The definition, assessment, between-group effect, P values and CIs for gel meibum quality
Conditions for verification: Original material on The definition, assessment, between-group effect, P values and CIs for gel meibum quality must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on The definition, assessment, between-group effect, P values and CIs for gel meibum quality is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N04 · What is the gland expressibility signal with 98% gel?

Required materials and conditions: Gland expressibility scales, measurement, between-group effects, P values and CIs
Conditions for verification: Original material on Gland expressibility scales, measurement, between-group effects, P values and CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Gland expressibility scales, measurement, between-group effects, P values and CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N05 · How do P values differ from effect size and precision?

Required materials and conditions: Sign-specific between-group estimates, variance and 95% CIs
Conditions for verification: Original material on Sign-specific between-group estimates, variance and 95% CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Sign-specific between-group estimates, variance and 95% CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N06 · Are improvement in all groups and added sign effects distinguished?

Required materials and conditions: Direct comparison conditions for each formulation and sign versus common care
Conditions for verification: Original material on Direct comparison conditions for each formulation and sign versus common care must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Direct comparison conditions for each formulation and sign versus common care is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N07 · Can drops, gel, staining and gland measures be interchanged?

Required materials and conditions: Matching 16% drop staining to 98% gel quality and expressibility
Conditions for verification: Original material on Matching 16% drop staining to 98% gel quality and expressibility must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Matching 16% drop staining to 98% gel quality and expressibility is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N08 · Are assessors and reproducibility of staining and meibum measurement verified?

Required materials and conditions: Original measurement, expression, assessment sites, scales and masking methods
Conditions for verification: Original material on Original measurement, expression, assessment sites, scales and masking methods must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Original measurement, expression, assessment sites, scales and masking methods is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N09 · How do the open 3-group design, multiple outcomes and selected signals relate?

Required materials and conditions: Prespecified primary outcomes, multiple signs and time points, and multiplicity plans
Conditions for verification: Original material on Prespecified primary outcomes, multiple signs and time points, and multiplicity plans must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Prespecified primary outcomes, multiple signs and time points, and multiplicity plans is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N10 · Does the supporting trial's signs list also provide exact effects?

Required materials and conditions: Tear-film, inflammation and staining results from the 59-participant trial
Conditions for verification: Original material on Tear-film, inflammation and staining results from the 59-participant trial must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Tear-film, inflammation and staining results from the 59-participant trial is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N11 · Are symptom superiority and sign signals different questions?

Required materials and conditions: The boundary of direct results for selected signs and the symptom question
Conditions for verification: Original material on The boundary of direct results for selected signs and the symptom question must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on The boundary of direct results for selected signs and the symptom question is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N12 · Do tear film, colonization and lubricant use share the same effect?

Required materials and conditions: Separate outcomes for other ocular-surface measures, mechanisms and medication use
Conditions for verification: Original material on Separate outcomes for other ocular-surface measures, mechanisms and medication use must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Separate outcomes for other ocular-surface measures, mechanisms and medication use is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N13 · How are the principal 8 weeks, supporting 3 weeks and long-term recovery distinguished?

Required materials and conditions: Sign-specific time points, exposure, post-stopping and long-term follow-up
Conditions for verification: Original material on Sign-specific time points, exposure, post-stopping and long-term follow-up must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Sign-specific time points, exposure, post-stopping and long-term follow-up is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N14 · How are medical-grade sterile products distinguished from food honey?

Required materials and conditions: Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel
Conditions for verification: Original material on Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N15 · What was added to common lid care?

Required materials and conditions: Warm compresses, massage, preservative-free lubricant and formulation-specific additional care
Conditions for verification: Original material on Warm compresses, massage, preservative-free lubricant and formulation-specific additional care must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Warm compresses, massage, preservative-free lubricant and formulation-specific additional care is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N16 · Are MGD diagnosis and sample size the same information?

Required materials and conditions: Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye
Conditions for verification: Original material on Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N17 · What are the selected-sign denominators in 114 participants and 3 groups?

Required materials and conditions: Group allocation, completion, analysis and endpoint-specific eye and patient denominators
Conditions for verification: Original material on Group allocation, completion, analysis and endpoint-specific eye and patient denominators must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Group allocation, completion, analysis and endpoint-specific eye and patient denominators is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N18 · What denominators are 59 randomized and 55 completed?

Required materials and conditions: Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators
Conditions for verification: Original material on Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N19 · What is the impact of missingness, attrition and measurement exclusions?

Required materials and conditions: Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses
Conditions for verification: Original material on Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N20 · What were the baseline adjustment, change and testing conditions?

Required materials and conditions: The effect of interest, baseline adjustment, change and final values, and variance
Conditions for verification: Original material on The effect of interest, baseline adjustment, change and final values, and variance must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on The effect of interest, baseline adjustment, change and final values, and variance is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N21 · Does a registration number also verify prespecified plans?

Required materials and conditions: Registration, history, primary outcomes, changes and original plans for both trials
Conditions for verification: Original material on Registration, history, primary outcomes, changes and original plans for both trials must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Registration, history, primary outcomes, changes and original plans for both trials is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N22 · Do parent and subquestions share the same reports?

Required materials and conditions: Report, trial and participant links between the symptom question and other questions
Conditions for verification: Original material on Report, trial and participant links between the symptom question and other questions must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Report, trial and participant links between the symptom question and other questions is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N23 · Is independent replication across teams, products and formulations verified?

Required materials and conditions: Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point
Conditions for verification: Original material on Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N24 · How much is known about product provision and company involvement?

Required materials and conditions: Trial-specific funding, product support, employee authors and conflicts
Conditions for verification: Original material on Trial-specific funding, product support, employee authors and conflicts must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Trial-specific funding, product support, employee authors and conflicts is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N25 · What is the scope of reported stinging and redness?

Required materials and conditions: Medical-grade product adverse reactions, collection methods, stopping and controls
Conditions for verification: Original material on Medical-grade product adverse reactions, collection methods, stopping and controls must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Medical-grade product adverse reactions, collection methods, stopping and controls is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N26 · What are the eye and patient harm denominators and exposures?

Required materials and conditions: Safety populations, eyes, patients, formulations, durations and actual instillation exposure
Conditions for verification: Original material on Safety populations, eyes, patients, formulations, durations and actual instillation exposure must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Safety populations, eyes, patients, formulations, durations and actual instillation exposure is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N27 · Are food or nonsterile risks distinguished from medical-grade product reactions?

Required materials and conditions: Manufacture, sterility, baseline eye conditions, other causes and clinical course
Conditions for verification: Original material on Manufacture, sterility, baseline eye conditions, other causes and clinical course must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Manufacture, sterility, baseline eye conditions, other causes and clinical course is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N28 · Are long-term, rare and vulnerable-population harms verified?

Required materials and conditions: Long exposure, independent harm reports, vulnerable populations and follow-up
Conditions for verification: Original material on Long exposure, independent harm reports, vulnerable populations and follow-up must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Supplementary
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on Long exposure, independent harm reports, vulnerable populations and follow-up is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N29 · How does stored-summary reading differ from reading external originals?

Required materials and conditions: The complete stored summary and the reading scope for external abstracts, full texts, registration and plans
Conditions for verification: Original material on The complete stored summary and the reading scope for external abstracts, full texts, registration and plans must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on The complete stored summary and the reading scope for external abstracts, full texts, registration and plans is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

N30 · What do selected C, parent C46, dates and empty values record?

Required materials and conditions: The selected grade, absent individual score, parent axes, evidence date and corrections
Conditions for verification: Original material on The selected grade, absent individual score, parent axes, evidence date and corrections must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Requirement and applicability: Required
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Why this condition is needed: Material on The selected grade, absent individual score, parent axes, evidence date and corrections is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed.

What the statuses mean

Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete.
Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.
Review incomplete: Review of existing content remains incomplete.
Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.
Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported.
Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned.
Not applicable: Used only with an application exception and reason based on the question scope.
Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work.
Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade.

Change history

2026-10-21 · Public page/material version 1.0

Public-facing views and materials were prepared from the existing 30 items. No new clinical search, verification-status change or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which signs question does this evidence check cover?

Current findings: The existing selected question is improvement in selected staining or meibomian signs. The original account of formulation-specific signals from a small open multiple-outcome trial is retained.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Selected findings are not expanded into all signs or symptom effects. Original formulation, sign, control and time-specific tables, denominators and CIs require additional material.
Required materials and conditions: Formulation-specific comparisons for improvement in selected staining and meibomian signs
Materials to obtain first: Selected findings are not expanded into all signs or symptom effects. Original formulation, sign, control and time-specific tables, denominators and CIs require additional material.
Further research: Material needed: Selected findings are not expanded into all signs or symptom effects. Original formulation, sign, control and time-specific tables, denominators and CIs require additional material. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Formulation-specific comparisons for improvement in selected staining and meibomian signs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Formulation-specific comparisons for improvement in selected staining and meibomian signs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N02 · What does the staining signal with 16% drops represent?

Current findings: The principal trial records staining with drops P=.035 as a selected between-group signal. Exact staining effects, scales and CIs are absent from the stored summary.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original staining sites, scales, assessors, time points, groups, denominators, effects and CIs remain unverified. The value is not converted into a symptom or gel result.
Required materials and conditions: Staining measurement with drops, between-group estimates, P values and CIs
Materials to obtain first: Original staining sites, scales, assessors, time points, groups, denominators, effects and CIs remain unverified. The value is not converted into a symptom or gel result.
Further research: Material needed: Original staining sites, scales, assessors, time points, groups, denominators, effects and CIs remain unverified. The value is not converted into a symptom or gel result. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Staining measurement with drops, between-group estimates, P values and CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Staining measurement with drops, between-group estimates, P values and CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N03 · What is the meibum quality signal with 98% gel?

Current findings: The original principal trial records gel meibum quality P=.005.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The same value is not copied to staining, gland expressibility or all signs. Grades, scales, assessment, expression methods, groups, denominators, time points, effects and CIs remain unverified.
Required materials and conditions: The definition, assessment, between-group effect, P values and CIs for gel meibum quality
Materials to obtain first: The same value is not copied to staining, gland expressibility or all signs. Grades, scales, assessment, expression methods, groups, denominators, time points, effects and CIs remain unverified.
Further research: Material needed: The same value is not copied to staining, gland expressibility or all signs. Grades, scales, assessment, expression methods, groups, denominators, time points, effects and CIs remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on The definition, assessment, between-group effect, P values and CIs for gel meibum quality must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on The definition, assessment, between-group effect, P values and CIs for gel meibum quality is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N04 · What is the gland expressibility signal with 98% gel?

Current findings: The original principal trial records gel gland expressibility P=.042. It is retained as a separate sign from meibum quality.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Gland selection, measurement, grades, assessors, groups, time points, denominators, effects and CIs remain unverified. New differences are not calculated.
Required materials and conditions: Gland expressibility scales, measurement, between-group effects, P values and CIs
Materials to obtain first: Gland selection, measurement, grades, assessors, groups, time points, denominators, effects and CIs remain unverified. New differences are not calculated.
Further research: Material needed: Gland selection, measurement, grades, assessors, groups, time points, denominators, effects and CIs remain unverified. New differences are not calculated. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Gland expressibility scales, measurement, between-group effects, P values and CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Gland expressibility scales, measurement, between-group effects, P values and CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N05 · How do P values differ from effect size and precision?

Current findings: The stored summary provides selected P values but does not retain exact formulation-specific effect sizes and intervals.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: P values alone do not newly verify large effects, precision, cure or equivalence. Original formulation-specific estimates, baseline and changes, denominators, variance, CIs and models remain unverified.
Required materials and conditions: Sign-specific between-group estimates, variance and 95% CIs
Materials to obtain first: P values alone do not newly verify large effects, precision, cure or equivalence. Original formulation-specific estimates, baseline and changes, denominators, variance, CIs and models remain unverified.
Further research: Material needed: P values alone do not newly verify large effects, precision, cure or equivalence. Original formulation-specific estimates, baseline and changes, denominators, variance, CIs and models remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Sign-specific between-group estimates, variance and 95% CIs must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Sign-specific between-group estimates, variance and 95% CIs is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N06 · Are improvement in all groups and added sign effects distinguished?

Current findings: Improvement in all groups is the common-care context. Selected between-group sign signals and before-and-after improvement within each group are retained separately.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Overall recovery is not assigned to honey as an ingredient. Common care, formulation-specific baselines, time points, all results and between-group contrast tables remain unverified.
Required materials and conditions: Direct comparison conditions for each formulation and sign versus common care
Materials to obtain first: Overall recovery is not assigned to honey as an ingredient. Common care, formulation-specific baselines, time points, all results and between-group contrast tables remain unverified.
Further research: Material needed: Overall recovery is not assigned to honey as an ingredient. Common care, formulation-specific baselines, time points, all results and between-group contrast tables remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Direct comparison conditions for each formulation and sign versus common care must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Direct comparison conditions for each formulation and sign versus common care is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N07 · Can drops, gel, staining and gland measures be interchanged?

Current findings: The original account distinguishes staining with drops from meibomian measures with gel. The 3 P values link to different formulations and measures.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: They are not pooled into a combined effect for one product or scale. Formulations, administration, scales, time points, group denominators and direct superiority comparisons remain unverified; formulation equivalence or superiority is not established.
Required materials and conditions: Matching 16% drop staining to 98% gel quality and expressibility
Materials to obtain first: They are not pooled into a combined effect for one product or scale. Formulations, administration, scales, time points, group denominators and direct superiority comparisons remain unverified; formulation equivalence or superiority is not established.
Further research: Material needed: They are not pooled into a combined effect for one product or scale. Formulations, administration, scales, time points, group denominators and direct superiority comparisons remain unverified; formulation equivalence or superiority is not established. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Matching 16% drop staining to 98% gel quality and expressibility must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Matching 16% drop staining to 98% gel quality and expressibility is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N08 · Are assessors and reproducibility of staining and meibum measurement verified?

Current findings: The original outcome list includes staining and meibum, but methods, scales, assessors and agreement are not detailed.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Successful assessor masking is not newly added to an open trial. Tests, scales, sites, gland selection, assessors, photographs, video, measurement records and time points remain unverified.
Required materials and conditions: Original measurement, expression, assessment sites, scales and masking methods
Materials to obtain first: Successful assessor masking is not newly added to an open trial. Tests, scales, sites, gland selection, assessors, photographs, video, measurement records and time points remain unverified.
Further research: Material needed: Successful assessor masking is not newly added to an open trial. Tests, scales, sites, gland selection, assessors, photographs, video, measurement records and time points remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Original measurement, expression, assessment sites, scales and masking methods must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Original measurement, expression, assessment sites, scales and masking methods is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N09 · How do the open 3-group design, multiple outcomes and selected signals relate?

Current findings: The original selected explanation and principal report retain the limitation of a small open multiple-outcome trial.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Selected positive P values do not establish prespecified primary-outcome success or positive findings for all outcomes. Registration, protocols, analysis plans, all result tables and multiplicity remain unverified; no new official risk assessment is created.
Required materials and conditions: Prespecified primary outcomes, multiple signs and time points, and multiplicity plans
Materials to obtain first: Selected positive P values do not establish prespecified primary-outcome success or positive findings for all outcomes. Registration, protocols, analysis plans, all result tables and multiplicity remain unverified; no new official risk assessment is created.
Further research: Material needed: Selected positive P values do not establish prespecified primary-outcome success or positive findings for all outcomes. Registration, protocols, analysis plans, all result tables and multiplicity remain unverified; no new official risk assessment is created. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Prespecified primary outcomes, multiple signs and time points, and multiplicity plans must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Prespecified primary outcomes, multiple signs and time points, and multiplicity plans is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N10 · Does the supporting trial's signs list also provide exact effects?

Current findings: The supporting trial's outcomes are 3-week SPEED, tear film, inflammation and staining. The stored result values are within-group SPEED changes.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: SPEED values or P values are not copied into sign results. Original sign-specific results, time points, denominators, formulation, hierarchy, between-group effects and CIs remain unverified.
Required materials and conditions: Tear-film, inflammation and staining results from the 59-participant trial
Materials to obtain first: SPEED values or P values are not copied into sign results. Original sign-specific results, time points, denominators, formulation, hierarchy, between-group effects and CIs remain unverified.
Further research: Material needed: SPEED values or P values are not copied into sign results. Original sign-specific results, time points, denominators, formulation, hierarchy, between-group effects and CIs remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Tear-film, inflammation and staining results from the 59-participant trial must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Tear-film, inflammation and staining results from the 59-participant trial is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N11 · Are symptom superiority and sign signals different questions?

Current findings: The parent and symptom question retain a gap in direct between-group symptom effects. Selected sign signals do not become symptom verification or new independent trials.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original symptom and sign tables, denominators, scales and matching within the same cohort remain unverified. Shared reports across the questions are not counted as separate independent replication.
Required materials and conditions: The boundary of direct results for selected signs and the symptom question
Materials to obtain first: Original symptom and sign tables, denominators, scales and matching within the same cohort remain unverified. Shared reports across the questions are not counted as separate independent replication.
Further research: Material needed: Original symptom and sign tables, denominators, scales and matching within the same cohort remain unverified. Shared reports across the questions are not counted as separate independent replication. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on The boundary of direct results for selected signs and the symptom question must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on The boundary of direct results for selected signs and the symptom question is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N12 · Do tear film, colonization and lubricant use share the same effect?

Current findings: The principal trial's outcome list also includes tear film, colonization and lubricant use.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The selected 3 P values are not used as effects on remaining outcomes, clinical symptoms or infection prevention. Each original outcome, hierarchy, value, denominator and between-group contrast remains unverified; unrecorded effects or CIs are not created.
Required materials and conditions: Separate outcomes for other ocular-surface measures, mechanisms and medication use
Materials to obtain first: The selected 3 P values are not used as effects on remaining outcomes, clinical symptoms or infection prevention. Each original outcome, hierarchy, value, denominator and between-group contrast remains unverified; unrecorded effects or CIs are not created.
Further research: Material needed: The selected 3 P values are not used as effects on remaining outcomes, clinical symptoms or infection prevention. Each original outcome, hierarchy, value, denominator and between-group contrast remains unverified; unrecorded effects or CIs are not created. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Separate outcomes for other ocular-surface measures, mechanisms and medication use must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Separate outcomes for other ocular-surface measures, mechanisms and medication use is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N13 · How are the principal 8 weeks, supporting 3 weeks and long-term recovery distinguished?

Current findings: The original principal direct trial spans 8 weeks and the supporting trial 3 weeks. Durations from different reports are distinguished.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Sign signals are not expanded into permanent gland recovery or long-term durability. Report-specific sign time points, administration, long-term and post-stopping course and direct results remain unverified.
Required materials and conditions: Sign-specific time points, exposure, post-stopping and long-term follow-up
Materials to obtain first: Sign signals are not expanded into permanent gland recovery or long-term durability. Report-specific sign time points, administration, long-term and post-stopping course and direct results remain unverified.
Further research: Material needed: Sign signals are not expanded into permanent gland recovery or long-term durability. Report-specific sign time points, administration, long-term and post-stopping course and direct results remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Sign-specific time points, exposure, post-stopping and long-term follow-up must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Sign-specific time points, exposure, post-stopping and long-term follow-up is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N14 · How are medical-grade sterile products distinguished from food honey?

Current findings: The original record concerns ophthalmic medical-grade products, not evidence for food-grade manuka honey or homemade dilution. Concentration differs from actual instilled amount and frequency.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Product, sterility, ingredients, manufacture, dose, frequency and administration records remain unverified in detail. Medical-grade product records are not expanded into effects of food-grade or nonsterile products.
Required materials and conditions: Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel
Materials to obtain first: Product, sterility, ingredients, manufacture, dose, frequency and administration records remain unverified in detail. Medical-grade product records are not expanded into effects of food-grade or nonsterile products.
Further research: Material needed: Product, sterility, ingredients, manufacture, dose, frequency and administration records remain unverified in detail. Medical-grade product records are not expanded into effects of food-grade or nonsterile products. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Manufacture, quality and actual administration of medical-grade 16% drops and 98% gel is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N15 · What was added to common lid care?

Current findings: In 2017, all groups used common warm compresses, lid massage and preservative-free lubricant. The comparison added medical-grade honey products to that care.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: It is not converted into evidence for stopping care or standalone treatment. Common-care rules, adherence, additional and rescue medications, formulation-specific matching and changes remain unverified.
Required materials and conditions: Warm compresses, massage, preservative-free lubricant and formulation-specific additional care
Materials to obtain first: It is not converted into evidence for stopping care or standalone treatment. Common-care rules, adherence, additional and rescue medications, formulation-specific matching and changes remain unverified.
Further research: Material needed: It is not converted into evidence for stopping care or standalone treatment. Common-care rules, adherence, additional and rescue medications, formulation-specific matching and changes remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Warm compresses, massage, preservative-free lubricant and formulation-specific additional care must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Warm compresses, massage, preservative-free lubricant and formulation-specific additional care is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N16 · Are MGD diagnosis and sample size the same information?

Current findings: The parent question concerns evaporative dry eye from meibomian gland dysfunction. 114 participants is the original sample-size label.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Sample size does not replace diagnostic or eligibility criteria. Diagnosis, severity, baseline symptoms and signs, age, comorbidities and group-specific inclusion and exclusion remain unverified.
Required materials and conditions: Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye
Materials to obtain first: Sample size does not replace diagnostic or eligibility criteria. Diagnosis, severity, baseline symptoms and signs, age, comorbidities and group-specific inclusion and exclusion remain unverified.
Further research: Material needed: Sample size does not replace diagnostic or eligibility criteria. Diagnosis, severity, baseline symptoms and signs, age, comorbidities and group-specific inclusion and exclusion remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Diagnosis, severity, baseline status and group-specific eligibility in evaporative dry eye is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N17 · What are the selected-sign denominators in 114 participants and 3 groups?

Current findings: The principal trial's sample was 114 participants and its design was an open 3-group randomized trial.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Group allocation, completion, formulations, care groups, endpoints, time points, bilateral-eye and patient denominators and exclusions remain unverified. Denominators absent from the original are not created.
Required materials and conditions: Group allocation, completion, analysis and endpoint-specific eye and patient denominators
Materials to obtain first: Group allocation, completion, formulations, care groups, endpoints, time points, bilateral-eye and patient denominators and exclusions remain unverified. Denominators absent from the original are not created.
Further research: Material needed: Group allocation, completion, formulations, care groups, endpoints, time points, bilateral-eye and patient denominators and exclusions remain unverified. Denominators absent from the original are not created. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Group allocation, completion, analysis and endpoint-specific eye and patient denominators must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Group allocation, completion, analysis and endpoint-specific eye and patient denominators is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N18 · What denominators are 59 randomized and 55 completed?

Current findings: The supporting trial originally recorded 59 randomized and 55 completed. These values describe separate stages.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Attrition counts or group-specific and endpoint-specific analysis denominators are not calculated or established. Group flow, reasons, time points and eye and patient denominators remain unverified.
Required materials and conditions: Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators
Materials to obtain first: Attrition counts or group-specific and endpoint-specific analysis denominators are not calculated or established. Group flow, reasons, time points and eye and patient denominators remain unverified.
Further research: Material needed: Attrition counts or group-specific and endpoint-specific analysis denominators are not calculated or established. Group flow, reasons, time points and eye and patient denominators remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Supporting-trial allocation, completion, analysis and group, eye and patient endpoint denominators is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N19 · What is the impact of missingness, attrition and measurement exclusions?

Current findings: Overall sample and completion records exist, but endpoint-specific missingness, attrition reasons and analysis conditions are not detailed.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Unread external material is not converted into absence of missingness. Missingness, stopping, exclusions, ITT and completer analyses, missing-data handling, sensitivity and group and eye matching remain unverified.
Required materials and conditions: Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses
Materials to obtain first: Unread external material is not converted into absence of missingness. Missingness, stopping, exclusions, ITT and completer analyses, missing-data handling, sensitivity and group and eye matching remain unverified.
Further research: Material needed: Unread external material is not converted into absence of missingness. Missingness, stopping, exclusions, ITT and completer analyses, missing-data handling, sensitivity and group and eye matching remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Group flow, missing selected-sign outcomes, analysis populations and sensitivity analyses is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N20 · What were the baseline adjustment, change and testing conditions?

Current findings: Original P values and selected changes are retained, but detailed adjustment, variance, time points, denominators and effects of interest remain unread in external originals.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Original analysis plans, statistical tables, baseline and changes, within-eye and within-person correlation, models and CIs remain unverified. New effects or CIs are not back-calculated.
Required materials and conditions: The effect of interest, baseline adjustment, change and final values, and variance
Materials to obtain first: Original analysis plans, statistical tables, baseline and changes, within-eye and within-person correlation, models and CIs remain unverified. New effects or CIs are not back-calculated.
Further research: Material needed: Original analysis plans, statistical tables, baseline and changes, within-eye and within-person correlation, models and CIs remain unverified. New effects or CIs are not back-calculated. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on The effect of interest, baseline adjustment, change and final values, and variance must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on The effect of interest, baseline adjustment, change and final values, and variance is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N21 · Does a registration number also verify prespecified plans?

Current findings: Registration was unverified for the principal trial, while NCT04457648 was recorded for the supporting trial.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The number's existence is not promoted into registration reading in this work, prespecification, hierarchy at all time points or plan adherence. Official registration history, protocols and analysis plans were unread in this work.
Required materials and conditions: Registration, history, primary outcomes, changes and original plans for both trials
Materials to obtain first: The number's existence is not promoted into registration reading in this work, prespecification, hierarchy at all time points or plan adherence. Official registration history, protocols and analysis plans were unread in this work.
Further research: Material needed: The number's existence is not promoted into registration reading in this work, prespecification, hierarchy at all time points or plan adherence. Official registration history, protocols and analysis plans were unread in this work. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Registration, history, primary outcomes, changes and original plans for both trials must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Registration, history, primary outcomes, changes and original plans for both trials is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

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N22 · Do parent and subquestions share the same reports?

Current findings: The parent and subquestions share the same Albietz 2017 and Wong 2021 reports.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Sheet counts are not counted as new studies or independent replications. Report, trial, registration, sample, institution, timing and additional-report matching and unique trial and participant totals remain unverified.
Required materials and conditions: Report, trial and participant links between the symptom question and other questions
Materials to obtain first: Sheet counts are not counted as new studies or independent replications. Report, trial, registration, sample, institution, timing and additional-report matching and unique trial and participant totals remain unverified.
Further research: Material needed: Sheet counts are not counted as new studies or independent replications. Report, trial, registration, sample, institution, timing and additional-report matching and unique trial and participant totals remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Report, trial and participant links between the symptom question and other questions must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Report, trial and participant links between the symptom question and other questions is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

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N23 · Is independent replication across teams, products and formulations verified?

Current findings: The bibliographies of both reports retain an Albietz author and the specific Optimel product context.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Different reports or assessor masking alone do not newly establish independent teams or replication under the same conditions. Team, institution, product, funding, participant, effect and denominator matching remain unverified.
Required materials and conditions: Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point
Materials to obtain first: Different reports or assessor masking alone do not newly establish independent teams or replication under the same conditions. Team, institution, product, funding, participant, effect and denominator matching remain unverified.
Further research: Material needed: Different reports or assessor masking alone do not newly establish independent teams or replication under the same conditions. Team, institution, product, funding, participant, effect and denominator matching remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Unique trials and independent teams for the same selected signs, formulation, population, comparison and time point is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N24 · How much is known about product provision and company involvement?

Current findings: The principal trial records Optimel product provision and related involvement; the supporting trial records a specific Optimel product, provision and author conflict disclosure.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Unrecorded funding, employee relationships, analysis and publication roles remain unverified. Product provision is not treated as verification of every involvement route or as absence of independence.
Required materials and conditions: Trial-specific funding, product support, employee authors and conflicts
Materials to obtain first: Unrecorded funding, employee relationships, analysis and publication roles remain unverified. Product provision is not treated as verification of every involvement route or as absence of independence.
Further research: Material needed: Unrecorded funding, employee relationships, analysis and publication roles remain unverified. Product provision is not treated as verification of every involvement route or as absence of independence. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Trial-specific funding, product support, employee authors and conflicts must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Trial-specific funding, product support, employee authors and conflicts is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N25 · What is the scope of reported stinging and redness?

Current findings: The original record reports temporary stinging and redness and cautions that initial symptoms are possible even with medical-grade formulations.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Event counts, incidence or new causality are not created. Collection methods, group and formulation-specific events, severity, timing, stopping, missingness and controls remain unverified.
Required materials and conditions: Medical-grade product adverse reactions, collection methods, stopping and controls
Materials to obtain first: Event counts, incidence or new causality are not created. Collection methods, group and formulation-specific events, severity, timing, stopping, missingness and controls remain unverified.
Further research: Material needed: Event counts, incidence or new causality are not created. Collection methods, group and formulation-specific events, severity, timing, stopping, missingness and controls remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Medical-grade product adverse reactions, collection methods, stopping and controls must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Medical-grade product adverse reactions, collection methods, stopping and controls is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N26 · What are the eye and patient harm denominators and exposures?

Current findings: 114 participants, 59 randomized and 55 completed do not verify safety denominators. Concentrations, formulations, 3 and 8 weeks and common care are not combined as the same harm exposure.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Safety denominators, actual instillation, group, eye and formulation-specific events, stopping, exposure and controls remain unverified. Incidence is not calculated.
Required materials and conditions: Safety populations, eyes, patients, formulations, durations and actual instillation exposure
Materials to obtain first: Safety denominators, actual instillation, group, eye and formulation-specific events, stopping, exposure and controls remain unverified. Incidence is not calculated.
Further research: Material needed: Safety denominators, actual instillation, group, eye and formulation-specific events, stopping, exposure and controls remain unverified. Incidence is not calculated. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Safety populations, eyes, patients, formulations, durations and actual instillation exposure must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Safety populations, eyes, patients, formulations, durations and actual instillation exposure is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N27 · Are food or nonsterile risks distinguished from medical-grade product reactions?

Current findings: The original caution distinguishes infection and corneal-injury risks with food-grade, nonsterile and homemade dilutions from initial stinging and redness with medical-grade products.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The food-honey self-instillation question is distinguished and no new case is created. Products, baseline eye conditions, concurrent use, event timing, alternative causes, controls and course remain unverified; no new harm causality is judged.
Required materials and conditions: Manufacture, sterility, baseline eye conditions, other causes and clinical course
Materials to obtain first: The food-honey self-instillation question is distinguished and no new case is created. Products, baseline eye conditions, concurrent use, event timing, alternative causes, controls and course remain unverified; no new harm causality is judged.
Further research: Material needed: The food-honey self-instillation question is distinguished and no new case is created. Products, baseline eye conditions, concurrent use, event timing, alternative causes, controls and course remain unverified; no new harm causality is judged. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Manufacture, sterility, baseline eye conditions, other causes and clinical course must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Manufacture, sterility, baseline eye conditions, other causes and clinical course is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N28 · Are long-term, rare and vulnerable-population harms verified?

Current findings: Small short-term trials of specific products and descriptions of temporary reactions do not verify long-term, rare or vulnerable-population safety.
Verification status: Unverified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: Long follow-up, independent harm reports, vulnerable populations, exposure, denominators, concurrent use and course remain unverified. No external search or new harm judgment was performed in this work.
Required materials and conditions: Long exposure, independent harm reports, vulnerable populations and follow-up
Materials to obtain first: Long follow-up, independent harm reports, vulnerable populations, exposure, denominators, concurrent use and course remain unverified. No external search or new harm judgment was performed in this work.
Further research: Material needed: Long follow-up, independent harm reports, vulnerable populations, exposure, denominators, concurrent use and course remain unverified. No external search or new harm judgment was performed in this work. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on Long exposure, independent harm reports, vulnerable populations and follow-up must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on Long exposure, independent harm reports, vulnerable populations and follow-up is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N29 · How does stored-summary reading differ from reading external originals?

Current findings: The complete parent Korean and English summary, reports and citations were read. PubMed URLs and registration numbers are existing records; external abstracts, full texts, registration, protocols and analysis plans were unread in this work.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: URLs, numbers and historical verification wording do not establish current reading, successful access or fulfilled conditions. External detailed-material availability, acquisition and actual reading remain separately unverified.
Required materials and conditions: The complete stored summary and the reading scope for external abstracts, full texts, registration and plans
Materials to obtain first: URLs, numbers and historical verification wording do not establish current reading, successful access or fulfilled conditions. External detailed-material availability, acquisition and actual reading remain separately unverified.
Further research: Material needed: URLs, numbers and historical verification wording do not establish current reading, successful access or fulfilled conditions. External detailed-material availability, acquisition and actual reading remain separately unverified. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on The complete stored summary and the reading scope for external abstracts, full texts, registration and plans must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on The complete stored summary and the reading scope for external abstracts, full texts, registration and plans is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02

N30 · What do selected C, parent C46, dates and empty values record?

Current findings: The selected grade is C, with no individual score, status or axes fields. Parent C46, caution, axes, Korean and English records, 2026-09-07 and empty correction and deliberation records are preserved separately.
Verification status: Partly verified
Materials actually read: Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread
Why unverified: This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.
Reason for missing information: The parent's 46 points are not assigned as a subclaim score, and the historical evidence date is not changed into a new search, external reading or completed-review date. New material, condition revisions and verdict changes are separate events.
Required materials and conditions: The selected grade, absent individual score, parent axes, evidence date and corrections
Materials to obtain first: The parent's 46 points are not assigned as a subclaim score, and the historical evidence date is not changed into a new search, external reading or completed-review date. New material, condition revisions and verdict changes are separate events.
Further research: Material needed: The parent's 46 points are not assigned as a subclaim score, and the historical evidence date is not changed into a new search, external reading or completed-review date. New material, condition revisions and verdict changes are separate events. This records needed materials; no new research was executed.
Remaining uncertainty: Exact formulation-specific sign effects, CIs, scales, measurement and reproducibility, group and eye denominators, baseline adjustment, missingness, prespecified hierarchy, exposure, independence, long-term effects and harms remain unverified. Original P values and historical verification wording are not promoted into new calculations, current external reading or completed clinical review.
Conditions for verification: Original material on The selected grade, absent individual score, parent axes, evidence date and corrections must link to the same question, control, endpoint, time point and denominators, distinguishing within- and between-group results, parent context and unread external materials.
Why this condition is needed: Material on The selected grade, absent individual score, parent axes, evidence date and corrections is needed to connect the medical-grade product, formulation-specific sign, existing care, population, comparison, measurement, time point, eye and patient denominators, precision and harms.
Application exceptions: Selected-signs C and absent individual score, status and axes are retained, distinguishing parent C46, symptom C and food-honey self-instillation F. Formulations, signs and P values are not combined or converted into symptoms or long-term recovery. Supporting within-group SPEED values are not transferred to signs or between-group symptom effects. No new effects, CIs, differences, attrition counts, incidence, denominators, unique totals, grades or individual-care guidance are created.
Referenced methods: Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.

Related sources R01 R02