Isolated tongue resistance training × AHI

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhat is the scope of the selected tongue-only question?Required	The selected original claim is 'AHI improvement from isolated tongue resistance training'. Distinguish multicomponent oropharyngeal AHI/symptoms and parent context covering multiple programs/endpoints; tongue-only AHI is recorded separately. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original Korean/English claim and boundaries from multicomponent/parent context	Material needed: Detailed exposure and the effect of interest for the selected protocol are unverified. This records needed materials; no new research was executed.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionAre subclaim D and parent C46 distinguished?Required	The original subclaim grade is D, with note that primary AHI was null in two small trials. Subclaim score/status are absent. Parent C46 is a historical verdict covering conflicting programs/endpoints, not a new subclaim score.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original subclaim D/note and absent score/status	Material needed: Subclaim score/status fields are absent from the original. Parent values are not copied to fill them. This records needed materials; no new research was executed.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionAre Poncin and Yoshioka populations the same?Required	Poncin bibliography concerns OSA patients; Yoshioka concerns mild-to-moderate sleep-disordered breathing. The parent has adult context. Exact ages, diagnoses, severity, baseline AHI, weight, exclusions and concurrent therapies for each tongue trial are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity	Material needed: Report-specific eligibility, diagnoses, baseline AHI, risks, ages and concurrent-treatment material are needed. This records needed materials; no new research was executed.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionAre tongue elevation, device resistance and multicomponent exercise the same intervention?Required	The original separates six-week sham-controlled tongue elevation, eight-week device-based tongue resistance with no-intervention control and three-month multicomponent oropharyngeal exercise. Retain the original boundary that muscles, components, supervision, tools and adherence define different interventions. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Muscles, components, supervision, tools and adherence	Material needed: Protocol-specific intensity, repetitions, tools, supervision and actual adherence are unverified. This records needed materials; no new research was executed.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWhat comparisons do sham and no intervention represent?Required	Distinguish tongue-only sham and no-intervention controls. Actual sham movements, contact time, concurrent standard therapy, medicines, other interventions and care-difference details are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Sham movements, contact, time, concurrent therapies and shared care	Material needed: Sham components, no-intervention conditions, contact, concurrent therapy and equal-care material are needed. This records needed materials; no new research was executed.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionWhich programs lasted six weeks, eight weeks and three months?Required	Preserve original correspondence between Poncin six weeks, Yoshioka eight weeks, Guimarães three months and their samples. Actual assessment dates, discontinuation, later follow-up and exact adherence durations are unverified. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific duration, assessment, exposure and later follow-up	Material needed: Exact assessment, actual exposure, discontinuation and later-follow-up material are needed. This records needed materials; no new research was executed.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow was tongue-only primary AHI measured and analyzed?Required	The original combined tongue summary describes primary AHI and null between-group results in two trials. Exact tongue-only AHI values, units, devices, scoring, baseline/change values, models and denominators are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	AHI definition, units, measurement, original values, denominators and models	Material needed: Report-specific AHI definitions, measurement, original values, units, baselines, denominators and models are needed. This records needed materials; no new research was executed.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhat was the original Poncin primary AHI result?Required	The original and its citation record null between-group primary AHI in Poncin. Exact Poncin arm AHI values, comparative estimates, P values, 95% CIs, denominators and models are unverified. R02	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Null comparative AHI, hierarchy, effects, CIs and denominators	Material needed: Exact Poncin effects, P values, CIs, arm denominators and models are needed. Yoshioka values are not copied. This records needed materials; no new research was executed.
9	Partly verified	Full text not readStored summary read	N09 · Evidence conditionAre secondary ESS and tongue endurance distinguished from AHI?Required	The original citation records Poncin primary AHI null and secondary ESS positive. Broad parent wording states that positive ESS/tongue endurance were secondary to failed primary AHI. Exact values, report-specific endurance attribution and measurement are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Poncin ESS, broad endurance wording, hierarchy and attribution	Material needed: Original ESS/endurance values, CIs, units, denominators and exact report attribution of endurance are needed. This records needed materials; no new research was executed.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionWhat is the scope of Yoshioka AHI P=.44?Required	Preserve Yoshioka AHI P=.44 and null comparative wording in the original, combined summary and citation. Exact arm AHI values, effects, CIs, denominators and models are unverified. R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original null comparative AHI, P value, effects and denominators	Material needed: Yoshioka arm AHI original values, effects, CIs, denominators and models are needed. This records needed materials; no new research was executed.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionWhat separate result does ESS P=.62 represent?Required	The original and citation specify Yoshioka ESS P=.62. It differs from positive Poncin secondary ESS and is a separate endpoint from AHI. Original ESS values, effects, CIs, denominators, prior hierarchy and timing details are unverified. R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Yoshioka ESS, times, denominators and separation from AHI	Material needed: Exact ESS values, effects, CIs, denominators, plans and times are needed. This records needed materials; no new research was executed.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionAre within-group AHI values from the 31-person multicomponent trial the selected effect?Required	Distinguish Guimarães exercise-group AHI 22.4±4.8 to 13.7±8.5/h from unavailable exact between-group change and 95% CI. This is background from a 31-person three-month multicomponent program, not a direct tongue-only effect. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Multicomponent exercise-group values and missing comparative estimates	Material needed: Exact multicomponent comparative change, CI, meaning of ±, arm denominators and models are unverified. This records needed materials; no new research was executed.
13	Partly verified	Full text not readStored summary read	N13 · Evidence conditionHow are multicomponent registered primary AHI and retrospective-registration wording retained?Required	The original multicomponent evidence row records registered primary AHI; its citation contains NCT00660777 and historical retrospective-registration checking wording. Exact registration dates, recruitment order and original plans remain unread and do not replace tongue-only plans. R01	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Guimarães NCT00660777, original hierarchy and registration timing	Material needed: Original multicomponent registration content, dates, plans, changes and recruitment order are needed. This records needed materials; no new research was executed.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionDo tongue strength/endurance, sleepiness and snoring answer AHI?Required	The original does not convert tongue strength, sleepiness or snoring into AHI success. Broad secondary-positive wording is retained separately from AHI; direct mediation and clinical links remain unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Measure definitions, units, primary/secondary hierarchy and clinical links	Material needed: Original values, measurement, hierarchy and AHI/clinical mediation links for each measure are needed. This records needed materials; no new research was executed.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionWhat is the scope of app scores and snoring signals?Required	Retain the original boundary that 'reduced app snoring = reduced AHI' lacks direct evidence. Detailed bibliography/quantification for symptom signals in other snoring trials is unverified; hypothetical reports are not added.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Actual reports, measurement and direct AHI links	Material needed: App/snoring original-report identity, measurement, values and direct AHI links are needed. This records needed materials; no new research was executed.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhat are exact tongue-only effects, CIs and effects of interest?Required	Null comparative AHI wording for two tongue trials and Yoshioka P values are present, but exact effects of interest, adjustments, 95% CIs, minimal important differences and equivalence designs are unverified. Retain the original boundary that small null trials do not establish null effects for every exercise. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Comparative estimation, adjustment, CIs, models and clinical importance	Material needed: Effects, CIs, effects of interest, adjustment, importance and equivalence plans are needed. This records needed materials; no new research was executed.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionWhat uncertainty remains with small samples of 27 and 20?Required	The parent identifies small studies and missing quantification as limitations. Original samples of 27 and 20 do not confirm precise null effects or universally rule out treatment effects; CIs and sample-size plans are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Endpoint denominators, intervals, power and follow-up	Material needed: AHI intervals, sample-size justification, power, importance and observation losses are needed. This records needed materials; no new research was executed.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionWhat do 27 and 20 represent in each report?Required	The original records multicomponent 31, six-week 27 and eight-week 20 separately; the combined tongue row records 27 and 20. Arm allocation, completion, analysis and AHI/ESS/strength denominators in each tongue trial are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original participants, arm allocation, completion and endpoint denominators	Material needed: Arm allocation, completion, analysis, endpoint denominators and exclusions are needed. This records needed materials; no new research was executed.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionHow does Yoshioka completer analysis relate to missingness?Required	The original Yoshioka citation marks 20 participants and completer analysis. Total allocation, arm completion/analysis, discontinuation, exclusions, AHI/ESS missing-data handling and Poncin flow details are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Allocation, completion, discontinuation, exclusions and endpoint missingness	Material needed: Allocation, completion, arm losses, exclusions and measure-specific missingness/handling are needed. This records needed materials; no new research was executed.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionHow much is known about random-sequence generation and concealment?Required	The combined tongue summary and bibliography of both tongue reports record randomized trials. Actual generation, concealment, recruitment order, arm allocation, baseline risks and implementation are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original randomized designs and actual generation, recruitment and allocation	Material needed: Actual random-sequence generation, concealment, recruitment, allocation and baseline-risk procedures are needed. This records needed materials; no new research was executed.
21	Partly verified	Full text not readStored summary read	N21 · Evidence conditionWhat level of sham, participant and assessor masking is known?Required	Distinguish Poncin sham from Yoshioka no intervention. Allocation awareness among participants, instructors, measurers and analysts, equal contact, sham movements, tools and measurement procedures are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Contact, allocation awareness, measurement and analysis procedures	Material needed: Masking, allocation awareness, sham content, contact, measurement and analysis procedures are needed. This records needed materials; no new research was executed.
22	Unverified	Full text not readStored summary read	N22 · Evidence conditionAre baseline AHI, severity, weight and analysis distinguished?Required	Exact tongue-only baseline AHI/ESS, severity, weight, arm balance and baseline handling/adjustment are unverified. Original within-group Guimarães 22.4 is not a tongue-only baseline. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Tongue-trial baselines, balance, covariates and adjustment	Material needed: Tongue-only baselines, covariates, balance, adjustment and models are needed. This records needed materials; no new research was executed.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionHow were standard therapy, other care and training compared?Required	The original summary records tongue-only/control programs, but details of concurrent standard therapy, other care, weight/treatment changes and model handling are unverified. Retain the original boundary that symptoms alone cannot determine treatment need. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Concurrent therapies, comparators, weight changes, treatment changes and analysis	Material needed: Standard therapy, concurrent treatment, care, weight changes and analysis handling are needed. This records needed materials; no new research was executed.
24	Partly verified	Full text not readStored summary read	N24 · Evidence conditionHow are actual adherence, tools and intensity linked to results?Required	The original states that muscles, components, supervision, tools and adherence define different interventions. Actual resistance, frequency, instruction, missed sessions, discontinuation and exposure-specific effects in the tongue trials are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Planned/actual exposure, resistance, supervision, discontinuation and analysis	Material needed: Actual intensity, frequency, adherence, supervision, discontinuation, exposure and analysis material are needed. This records needed materials; no new research was executed.
25	Unverified	Full text not readStored summary read	N25 · Evidence conditionWhat are allocation, completer and actual-use effects and missing-data handling?Required	Beyond original Yoshioka completer wording, ITT/PP, actual use, missingness, imputation, sensitivity, models and covariates in each tongue trial are unverified. Original comparative null wording is retained only within original-report scope. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	ITT/PP, adjustment, missingness, sensitivity and repeated measures	Material needed: ITT/PP, actual use, models, adjustment, missingness and sensitivity material are needed. This records needed materials; no new research was executed.
26	Partly verified	Full text not readStored summary read	N26 · Evidence conditionWhat do NCT/UMIN identifiers and the original primary hierarchy establish?Required	Original tongue bibliography includes NCT03846349 and UMIN000041489; original evidence/citations record null primary AHI. Current registration content, dates, recruitment order, changes and analysis plans remain unread. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Tongue-report registration, protocols, primary AHI and secondary outcomes	Material needed: Registration content, dates, plans, hierarchy, analysis, recruitment order and change history are needed. This records needed materials; no new research was executed.
27	Partly verified	Full text not readStored summary read	N27 · Evidence conditionHow are tongue-only null results and multicomponent signals preserved together?Required	The parent did not combine programs into blanket benefit or null conclusions. Retain separate scopes of multicomponent within-group signals, tongue-only primary null results and symptoms/strength/endurance; small null trials do not establish null effects for every possible exercise. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Each comparator, duration, components, endpoints and quantification	Material needed: Direct comparisons under the same conditions, effects, CIs, independence and quantitative links are unverified. This records needed materials; no new research was executed.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionHow do two evidence groups, three bibliographies and historical five RCTs differ?Required	The original contains two evidence rows and three citations. The parent decision historically describes five RCTs/registry cross-checking, but the full list and additional-report details are unverified. Link the combined tongue summary within each of two separate bibliographies; no hypothetical reports are added. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Combined summaries, individual bibliography, historical study counts and cohorts	Material needed: Related/additional reports, cohort overlap and unique-trial/participant totals are unverified. This records needed materials; no new research was executed.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionWhich trial and roles do public/university support and device provision concern?Required	The original multicomponent row records limited funding verification; the combined tongue row records public/university support and device provision in one trial. Which trial received the device, and support, COI, design/analysis roles and independence details, are unverified. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Report-specific support, COI, devices, design, analysis and independence	Material needed: Individual attribution of support/device provision, COI, roles, research families and independence material are needed. This records needed materials; no new research was executed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionDo the studies answer post-training AHI and clinical outcomes?Required	There is assessment context for six/eight-week tongue programs, but post-training AHI, clinical events, other durations/intensities/subgroups and standard-treatment-replacement material are unverified. Retain the original boundary that symptoms alone cannot determine severity or treatment need. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Later follow-up, other conditions, subgroups and treatment changes	Material needed: Later follow-up, clinical outcomes, other conditions, subgroups and treatment-change material are needed. This records needed materials; no new research was executed.
31	Partly verified	Full text not readStored summary read	N31 · Evidence conditionWhat material was actually read here?Required	The complete stored parent 2992 summary and original bibliography were used and originals preserved. The three reports were read as summaries; external abstracts, full texts, registration, plans and support material remain unread without access attempts. The 24 material slots comprise three stored summaries and 21 unread/needed external-material slots. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Complete stored summary/bibliography versus external originals	Material needed: External originals remain unread. Access failure or inaccessibility was not established either. This records needed materials; no new research was executed.
32	Partly verified	Full text not readStored summary read	N32 · Evidence conditionAre historical cross-checking and current review distinguished?Required	Retain original 2026-09-07, an empty corrections array and empty deliberation string. Historical checking of five RCTs, registration and primary outcomes is a parent history record, not completed current review.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original date, empty corrections/deliberation and historical decision	Material needed: Current content-review and new clinical-verification dates are unrecorded; review of existing content remains incomplete. This records needed materials; no new research was executed.
33	Partly verified	Full text not readStored summary read	N33 · Evidence conditionAre original Korean/English tongue-only, multicomponent, primary and symptom boundaries retained?Required	The original English subclaim is 'AHI improvement from isolated tongue resistance training', with note that primary AHI was null in two small trials. Parent English also distinguishes multicomponent/tongue-only and primary outcomes/symptoms/strength. No detailed external comparison was performed.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Original subclaim/note, parent Korean/English and safety	Material needed: Detailed translation/correction comparisons between external papers and original Korean/English remain unverified. This records needed materials; no new research was executed.
34	Partly verified	Full text not readStored summary read	N34 · Evidence conditionHow are parent axes and failed primary/positive secondary outcomes retained?Required	Parent axes are B/S/R0/I1/EX/B2/CX; the primary-failed-secondary-positive flag is true. Coprimary split, large hard-endpoint RCT and no-human-study flags are false. Derived grade is C; override is an empty string. Subclaim score, status and axes are absent from the original.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Parent axes, original flags and absent subclaim axes	Material needed: Selected-subclaim score, status and axes are absent; details of each original endpoint plan are unverified. This records needed materials; no new research was executed.
35	Partly verified	Full text not readStored summary read	N35 · Evidence conditionWhich trial does the one mucosal-abrasion participant belong to?Supplementary; required for extending safety conclusions	The original safety wording records one exercise-arm participant in a tongue-training trial temporarily stopping because of an oral mucosal abrasion, then resuming. Exact trial attribution, definition, collection, adjudication and denominators are unverified in the current summary. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Event attribution, definition, collection, adjudication and denominator	Material needed: Trial attribution, definitions, collection, adjudication, exposure and observation denominators for the abrasion are needed. This records needed materials; no new research was executed.
36	Unverified	Full text not readStored summary read	N36 · Evidence conditionWhat are abrasion onset, stopping/resumption and follow-up times?Supplementary; required for extending safety conclusions	The original records resumption after temporary discontinuation. Exposure, onset, recovery, discontinuation duration, recurrence, later harm follow-up and exact trial attribution are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Actual exposure, onset, recovery, stopping, recurrence and follow-up	Material needed: Event, recovery, discontinuation duration, recurrence and later-follow-up times are needed. This records needed materials; no new research was executed.
37	Unverified	Full text not readStored summary read	N37 · Evidence conditionWere harms collected equally in sham/no-intervention groups?Supplementary; required for extending safety conclusions	Tongue-only sham/no-intervention comparisons exist, but equal harm collection, observation periods, control event counts/denominators, comparative risks and attribution of the one participant are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Arm collection, observation, control events and denominators	Material needed: Equal harm collection/observation, control events, denominators and comparative material are needed. This records needed materials; no new research was executed.
38	Unverified	Full text not readStored summary read	N38 · Evidence conditionAre exposure/observation denominators and abrasion frequency known?Supplementary; required for extending safety conclusions	The original describes one abrasion participant, but exposure/observation denominators, arm/trial attribution, total harms and missingness are unverified. Original samples of 27 and 20 are not that harm denominator. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Exact trial/arm, actual exposure, follow-up, harms and discontinuation	Material needed: Harm attribution, exposure, follow-up, arm denominators and total harm counts are needed. No new frequencies or risks are calculated. This records needed materials; no new research was executed.
39	Partly verified	Full text not readStored summary read	N39 · Evidence conditionAre tools, training, baseline conditions and event causes distinguished?Supplementary; required for extending safety conclusions	Original mucosal-abrasion/temporary-stopping wording exists, but tool/program attribution, actual exposure, baseline conditions, concurrent care, timing and causal-adjudication details are unverified. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause	Material needed: Tools, exposure, baseline conditions, event attribution, timing and causal assessment are needed. This records needed materials; no new research was executed.
40	Unverified	Full text not readStored summary read	N40 · Evidence conditionWhat are stopping, completer analysis and losses to harm follow-up?Supplementary; required for extending safety conclusions	Temporary stopping/resumption and Yoshioka completer analysis are separate original records. Arm-specific stopping/losses, missing or selected harm reporting and later follow-up in each report are unverified. The two statements are not linked as the same trial/participant. R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Event stopping/resumption, losses, harm missingness and selective reporting	Material needed: Harm-related stopping, losses, missingness, selective reporting and follow-up losses are needed. This records needed materials; no new research was executed.
41	Unverified	Full text not readStored summary read	N41 · Evidence conditionWhat is known about other populations, independent reports and later harms?Supplementary; required for extending safety conclusions	Stored scope covers program-specific AHI/symptoms and one abrasion participant with unverified attribution. Independent harm reports under the same protocol, other severities/disease populations and post-training observation are unverified. R01 R02 R03	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Same protocol, vulnerable populations, severity and long-term follow-up	Material needed: Independent harm material, vulnerable/severe populations and post-training follow-up are needed. This records needed materials; no new research was executed.
42	Partly verified	Full text not readStored summary read	N42 · Evidence conditionAre criteria/original preservation distinguished from content review?Required	Preserved methodology, claim-type conditions and review-scope material were referenced. Condition freezing and separate observation application are distinguished from actual original-material reading/content review. Existing content review remains incomplete; this does not establish official-method certification or new clinical verification.	The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.	Preserved methodology, condition versions, separate application and actual review scope	Material needed: Update with records of original material, condition versions, separate application, change history and actual review scope. This records needed materials; no new research was executed.

No items match your search or filter.

42 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-09-07
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Distinguish original report populations of 27 OSA patients in Poncin and 20 with mild-to-moderate sleep-disordered breathing in Yoshioka. Exact ages, diagnoses, baseline AHI/ESS, weight, exclusions, arm denominators and concurrent therapy are unverified. The 31-person multicomponent Guimarães trial is not copied as a tongue-only population, denominator or baseline.
Ingredient, formulation and route: Record isolated six-week tongue elevation and eight-week device-based tongue resistance within their original scopes. Retain differences in muscles, components, supervision, tools and adherence; multicomponent oropharyngeal exercise is separate background. Exact intensity, repetitions, device specifications and actual adherence are unverified; no new training methods are provided.
Dose: Preserve original programs/durations only to identify studies. Exact tongue-only intensity, repetitions, actual exposure, resistance, instruction, missed sessions and discontinuation details are unverified. Total amounts, frequency and individual intensity are not newly converted; no training/treatment prescriptions are created.
Comparator: Distinguish sham in Poncin from no intervention in Yoshioka. Actual sham movements, contact time, allocation awareness, measurement/analysis masking, concurrent standard therapy, medicines, weight and lifestyle-care differences are unverified. Different controls are not combined as the same comparison.
Measured outcome: The selected original claim is AHI improvement from isolated tongue resistance training, with subclaim grade D and note that primary AHI was null in two small trials. Distinguish Poncin null between-group primary AHI/positive secondary ESS from Yoshioka AHI P=.44/ESS P=.62. Exact tongue-only AHI values, units, measurement, models, effects, CIs and denominators are unverified. Multicomponent within-group values, tongue strength/endurance, sleepiness and app snoring are not transferred into selected AHI effects.
Duration: Preserve original durations of six weeks in Poncin and eight weeks in Yoshioka. Exact assessment dates, actual exposure durations, discontinuation, later follow-up, long-term clinical outcomes and rare harms are unverified. Three months for the multicomponent program is not the duration for this tongue-only question; no standard-treatment replacement or method instructions are created.
Questions outside this scope: Copying or calculating within-exercise-group 22.4±4.8 to 13.7±8.5/h in the 31-person multicomponent trial as tongue-only baselines, comparative effects or CIs; Converting Poncin secondary ESS, broad endurance wording, tongue strength, sleepiness or app snoring into primary AHI success; Copying Yoshioka P=.44/P=.62, 20 participants or completer analysis into Poncin values, denominators or analyses; Assigning one abrasion participant or device provision to a specific tongue trial without support, or using 27/20 participants as harm denominators; Using historical five RCTs, reports, measures or two subclaim sheets as new unique-trial, participant or event totals, or independence certification; Regrading original D/null results as zero effect, equivalence or null effects of every exercise, or filling subclaim scores with parent C46; Creating new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, tongue/breathing training, standard-treatment replacement or procedure instructions

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Guimarães KC et al. 2009

PubMed

Material type: Randomized multicomponent oropharyngeal exercise trial
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread without access attempts
Findings recorded in the stored summary: Within-exercise-group AHI 22.4±4.8 to 13.7±8.5/h; exact between-group change/CI unverified
Record level: Background within-exercise-group AHI from the 31-person three-month multicomponent trial. Retain original registered primary AHI, AHI/ESS signals and retrospective-registration wording; exact comparative effects, 95% CI, the meaning of ±, denominators and plans are unverified. They are not transferred into tongue-only baselines, comparative effects, intervals or duration.
Study overlap and independent replication: The original parent and two subclaim sheets share the same report context. R01 Guimarães is multicomponent background; distinguish the original combined tongue summary into R02 Poncin six weeks/27 participants/sham and R03 Yoshioka eight weeks/20 participants/no intervention. Three current bibliographies, historical checks of five RCTs, repeated measures and material slots are not counted as new unique trials, participants, events or independent replications. Confirmed totals and external details are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Summary read	Summary read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Registration	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Analysis plan and original tables	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Intervention and harms	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Support and interests	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 19234106, DOI 10.1164/rccm.200806-981OC, NCT00660777 and unrecorded PMCID are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.

R02 · Poncin W et al. 2022

PubMed

Material type: Sham-controlled randomized tongue-elevation trial; separate from the multicomponent program
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread without access attempts
Findings recorded in the stored summary: Tongue-only primary AHI null and secondary ESS positive; exact effects, CIs and P values unverified
Record level: The original combined summary records Poncin 27 and Yoshioka 20 together. Poncin six-week sham comparison, primary AHI null and secondary ESS signal are linked separately; arm denominators, exact effects, CIs, P values and report-specific attribution of tongue endurance are unverified.
Study overlap and independent replication: The original parent and two subclaim sheets share the same report context. R01 Guimarães is multicomponent background; distinguish the original combined tongue summary into R02 Poncin six weeks/27 participants/sham and R03 Yoshioka eight weeks/20 participants/no intervention. Three current bibliographies, historical checks of five RCTs, repeated measures and material slots are not counted as new unique trials, participants, events or independent replications. Confirmed totals and external details are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Summary read	Summary read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Registration	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Analysis plan and original tables	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Intervention and harms	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Support and interests	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 36081312, PMCID PMC9826101, DOI 10.1111/joor.13369 and NCT03846349 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.

R03 · Yoshioka J et al. 2024

PubMed

Material type: Randomized device-based tongue-resistance trial with no-intervention control; separate from the multicomponent program
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread without access attempts
Findings recorded in the stored summary: Tongue-only AHI P=.44 and ESS P=.62; 20 participants and completer analysis
Record level: Distinguish the original combined summary from individual bibliography. Retain Yoshioka eight-week no-intervention comparison, 20 participants, completer analysis and AHI/ESS P values. Poncin secondary ESS positivity or combined funding/device support is not copied into Yoshioka-specific results/support.
Study overlap and independent replication: The original parent and two subclaim sheets share the same report context. R01 Guimarães is multicomponent background; distinguish the original combined tongue summary into R02 Poncin six weeks/27 participants/sham and R03 Yoshioka eight weeks/20 participants/no intervention. Three current bibliographies, historical checks of five RCTs, repeated measures and material slots are not counted as new unique trials, participants, events or independent replications. Confirmed totals and external details are unverified.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored existing review summary	Preserved copy of the complete parent-verdict stored summary	Summary read	Summary read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Abstract	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Full text	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Registration	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Protocol	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Analysis plan and original tables	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Intervention and harms	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.
Support and interests	Original bibliographic link or needed material; external public availability/access status unverified	Unread; access not attempted	Not read	The original PubMed URL and PMID 38529043, PMCID PMC10961225, DOI 10.2490/prm.20240010 and UMIN000041489 are preserved. Identifiers alone do not certify original-material acquisition, reading, prior plans or condition fulfillment; full-text/registration URLs are not newly inferred.

Report counts versus independent study counts

The original parent and two subclaim sheets share the same report context. R01 Guimarães is multicomponent background; distinguish the original combined tongue summary into R02 Poncin six weeks/27 participants/sham and R03 Yoshioka eight weeks/20 participants/no intervention. Three current bibliographies, historical checks of five RCTs, repeated measures and material slots are not counted as new unique trials, participants, events or independent replications. Confirmed totals and external details are unverified.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · What is the scope of the selected tongue-only question?

Required materials and conditions: Original Korean/English claim and boundaries from multicomponent/parent context
Conditions for verification: Material for Original Korean/English claim and boundaries from multicomponent/parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original Korean/English claim and boundaries from multicomponent/parent context with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N02 · Are subclaim D and parent C46 distinguished?

Required materials and conditions: Original subclaim D/note and absent score/status
Conditions for verification: Material for Original subclaim D/note and absent score/status must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original subclaim D/note and absent score/status with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N03 · Are Poncin and Yoshioka populations the same?

Required materials and conditions: OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity
Conditions for verification: Material for OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N04 · Are tongue elevation, device resistance and multicomponent exercise the same intervention?

Required materials and conditions: Muscles, components, supervision, tools and adherence
Conditions for verification: Material for Muscles, components, supervision, tools and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Muscles, components, supervision, tools and adherence with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N05 · What comparisons do sham and no intervention represent?

Required materials and conditions: Sham movements, contact, time, concurrent therapies and shared care
Conditions for verification: Material for Sham movements, contact, time, concurrent therapies and shared care must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Sham movements, contact, time, concurrent therapies and shared care with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N06 · Which programs lasted six weeks, eight weeks and three months?

Required materials and conditions: Report-specific duration, assessment, exposure and later follow-up
Conditions for verification: Material for Report-specific duration, assessment, exposure and later follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Report-specific duration, assessment, exposure and later follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N07 · How was tongue-only primary AHI measured and analyzed?

Required materials and conditions: AHI definition, units, measurement, original values, denominators and models
Conditions for verification: Material for AHI definition, units, measurement, original values, denominators and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects AHI definition, units, measurement, original values, denominators and models with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N08 · What was the original Poncin primary AHI result?

Required materials and conditions: Null comparative AHI, hierarchy, effects, CIs and denominators
Conditions for verification: Material for Null comparative AHI, hierarchy, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Null comparative AHI, hierarchy, effects, CIs and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N09 · Are secondary ESS and tongue endurance distinguished from AHI?

Required materials and conditions: Poncin ESS, broad endurance wording, hierarchy and attribution
Conditions for verification: Material for Poncin ESS, broad endurance wording, hierarchy and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Poncin ESS, broad endurance wording, hierarchy and attribution with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N10 · What is the scope of Yoshioka AHI P=.44?

Required materials and conditions: Original null comparative AHI, P value, effects and denominators
Conditions for verification: Material for Original null comparative AHI, P value, effects and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original null comparative AHI, P value, effects and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N11 · What separate result does ESS P=.62 represent?

Required materials and conditions: Yoshioka ESS, times, denominators and separation from AHI
Conditions for verification: Material for Yoshioka ESS, times, denominators and separation from AHI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Yoshioka ESS, times, denominators and separation from AHI with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N12 · Are within-group AHI values from the 31-person multicomponent trial the selected effect?

Required materials and conditions: Multicomponent exercise-group values and missing comparative estimates
Conditions for verification: Material for Multicomponent exercise-group values and missing comparative estimates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Multicomponent exercise-group values and missing comparative estimates with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N13 · How are multicomponent registered primary AHI and retrospective-registration wording retained?

Required materials and conditions: Guimarães NCT00660777, original hierarchy and registration timing
Conditions for verification: Material for Guimarães NCT00660777, original hierarchy and registration timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Guimarães NCT00660777, original hierarchy and registration timing with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N14 · Do tongue strength/endurance, sleepiness and snoring answer AHI?

Required materials and conditions: Measure definitions, units, primary/secondary hierarchy and clinical links
Conditions for verification: Material for Measure definitions, units, primary/secondary hierarchy and clinical links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Measure definitions, units, primary/secondary hierarchy and clinical links with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N15 · What is the scope of app scores and snoring signals?

Required materials and conditions: Actual reports, measurement and direct AHI links
Conditions for verification: Material for Actual reports, measurement and direct AHI links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Actual reports, measurement and direct AHI links with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N16 · What are exact tongue-only effects, CIs and effects of interest?

Required materials and conditions: Comparative estimation, adjustment, CIs, models and clinical importance
Conditions for verification: Material for Comparative estimation, adjustment, CIs, models and clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Comparative estimation, adjustment, CIs, models and clinical importance with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N17 · What uncertainty remains with small samples of 27 and 20?

Required materials and conditions: Endpoint denominators, intervals, power and follow-up
Conditions for verification: Material for Endpoint denominators, intervals, power and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Endpoint denominators, intervals, power and follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N18 · What do 27 and 20 represent in each report?

Required materials and conditions: Original participants, arm allocation, completion and endpoint denominators
Conditions for verification: Material for Original participants, arm allocation, completion and endpoint denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original participants, arm allocation, completion and endpoint denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N19 · How does Yoshioka completer analysis relate to missingness?

Required materials and conditions: Allocation, completion, discontinuation, exclusions and endpoint missingness
Conditions for verification: Material for Allocation, completion, discontinuation, exclusions and endpoint missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Allocation, completion, discontinuation, exclusions and endpoint missingness with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N20 · How much is known about random-sequence generation and concealment?

Required materials and conditions: Original randomized designs and actual generation, recruitment and allocation
Conditions for verification: Material for Original randomized designs and actual generation, recruitment and allocation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original randomized designs and actual generation, recruitment and allocation with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N21 · What level of sham, participant and assessor masking is known?

Required materials and conditions: Contact, allocation awareness, measurement and analysis procedures
Conditions for verification: Material for Contact, allocation awareness, measurement and analysis procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Contact, allocation awareness, measurement and analysis procedures with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N22 · Are baseline AHI, severity, weight and analysis distinguished?

Required materials and conditions: Tongue-trial baselines, balance, covariates and adjustment
Conditions for verification: Material for Tongue-trial baselines, balance, covariates and adjustment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Tongue-trial baselines, balance, covariates and adjustment with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N23 · How were standard therapy, other care and training compared?

Required materials and conditions: Concurrent therapies, comparators, weight changes, treatment changes and analysis
Conditions for verification: Material for Concurrent therapies, comparators, weight changes, treatment changes and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Concurrent therapies, comparators, weight changes, treatment changes and analysis with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N24 · How are actual adherence, tools and intensity linked to results?

Required materials and conditions: Planned/actual exposure, resistance, supervision, discontinuation and analysis
Conditions for verification: Material for Planned/actual exposure, resistance, supervision, discontinuation and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Planned/actual exposure, resistance, supervision, discontinuation and analysis with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N25 · What are allocation, completer and actual-use effects and missing-data handling?

Required materials and conditions: ITT/PP, adjustment, missingness, sensitivity and repeated measures
Conditions for verification: Material for ITT/PP, adjustment, missingness, sensitivity and repeated measures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects ITT/PP, adjustment, missingness, sensitivity and repeated measures with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N26 · What do NCT/UMIN identifiers and the original primary hierarchy establish?

Required materials and conditions: Tongue-report registration, protocols, primary AHI and secondary outcomes
Conditions for verification: Material for Tongue-report registration, protocols, primary AHI and secondary outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Tongue-report registration, protocols, primary AHI and secondary outcomes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N27 · How are tongue-only null results and multicomponent signals preserved together?

Required materials and conditions: Each comparator, duration, components, endpoints and quantification
Conditions for verification: Material for Each comparator, duration, components, endpoints and quantification must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Each comparator, duration, components, endpoints and quantification with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N28 · How do two evidence groups, three bibliographies and historical five RCTs differ?

Required materials and conditions: Combined summaries, individual bibliography, historical study counts and cohorts
Conditions for verification: Material for Combined summaries, individual bibliography, historical study counts and cohorts must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Combined summaries, individual bibliography, historical study counts and cohorts with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N29 · Which trial and roles do public/university support and device provision concern?

Required materials and conditions: Report-specific support, COI, devices, design, analysis and independence
Conditions for verification: Material for Report-specific support, COI, devices, design, analysis and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Report-specific support, COI, devices, design, analysis and independence with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N30 · Do the studies answer post-training AHI and clinical outcomes?

Required materials and conditions: Later follow-up, other conditions, subgroups and treatment changes
Conditions for verification: Material for Later follow-up, other conditions, subgroups and treatment changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Later follow-up, other conditions, subgroups and treatment changes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N31 · What material was actually read here?

Required materials and conditions: Complete stored summary/bibliography versus external originals
Conditions for verification: Material for Complete stored summary/bibliography versus external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Complete stored summary/bibliography versus external originals with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N32 · Are historical cross-checking and current review distinguished?

Required materials and conditions: Original date, empty corrections/deliberation and historical decision
Conditions for verification: Material for Original date, empty corrections/deliberation and historical decision must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original date, empty corrections/deliberation and historical decision with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N33 · Are original Korean/English tongue-only, multicomponent, primary and symptom boundaries retained?

Required materials and conditions: Original subclaim/note, parent Korean/English and safety
Conditions for verification: Material for Original subclaim/note, parent Korean/English and safety must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Original subclaim/note, parent Korean/English and safety with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N34 · How are parent axes and failed primary/positive secondary outcomes retained?

Required materials and conditions: Parent axes, original flags and absent subclaim axes
Conditions for verification: Material for Parent axes, original flags and absent subclaim axes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Parent axes, original flags and absent subclaim axes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N35 · Which trial does the one mucosal-abrasion participant belong to?

Required materials and conditions: Event attribution, definition, collection, adjudication and denominator
Conditions for verification: Material for Event attribution, definition, collection, adjudication and denominator must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Event attribution, definition, collection, adjudication and denominator with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N36 · What are abrasion onset, stopping/resumption and follow-up times?

Required materials and conditions: Actual exposure, onset, recovery, stopping, recurrence and follow-up
Conditions for verification: Material for Actual exposure, onset, recovery, stopping, recurrence and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Actual exposure, onset, recovery, stopping, recurrence and follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N37 · Were harms collected equally in sham/no-intervention groups?

Required materials and conditions: Arm collection, observation, control events and denominators
Conditions for verification: Material for Arm collection, observation, control events and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Arm collection, observation, control events and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N38 · Are exposure/observation denominators and abrasion frequency known?

Required materials and conditions: Exact trial/arm, actual exposure, follow-up, harms and discontinuation
Conditions for verification: Material for Exact trial/arm, actual exposure, follow-up, harms and discontinuation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Exact trial/arm, actual exposure, follow-up, harms and discontinuation with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N39 · Are tools, training, baseline conditions and event causes distinguished?

Required materials and conditions: Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause
Conditions for verification: Material for Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N40 · What are stopping, completer analysis and losses to harm follow-up?

Required materials and conditions: Event stopping/resumption, losses, harm missingness and selective reporting
Conditions for verification: Material for Event stopping/resumption, losses, harm missingness and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Event stopping/resumption, losses, harm missingness and selective reporting with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N41 · What is known about other populations, independent reports and later harms?

Required materials and conditions: Same protocol, vulnerable populations, severity and long-term follow-up
Conditions for verification: Material for Same protocol, vulnerable populations, severity and long-term follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Supplementary; required for extending safety conclusions
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Same protocol, vulnerable populations, severity and long-term follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

N42 · Are criteria/original preservation distinguished from content review?

Required materials and conditions: Preserved methodology, condition versions, separate application and actual review scope
Conditions for verification: Material for Preserved methodology, condition versions, separate application and actual review scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Requirement and applicability: Required
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Why this condition is needed: This condition connects Preserved methodology, condition versions, separate application and actual review scope with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

What the statuses mean

Met: The original content has been reviewed as meeting the conditions. This status is not used in this preparation.
Partly verified: Some information in the stored summary was linked during preparation; clinical verification or review is not complete.
Unverified: Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.
Review incomplete: Awaiting user review, or actual review remains incomplete.
Not reported: Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.
Inaccessible: Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.
Insufficient evidence for the conditions: Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.
Not applicable: Used when the reason it does not apply to the original question is stated.
Conflicting data: Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment.

Change history

2026-10-16 · Public page/material version 1.0

Public pages and materials were created from the existing 42 items. No new clinical search, verification-status change, or scoring was performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-09-07) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · What is the scope of the selected tongue-only question?

Current findings: The selected original claim is 'AHI improvement from isolated tongue resistance training'. Distinguish multicomponent oropharyngeal AHI/symptoms and parent context covering multiple programs/endpoints; tongue-only AHI is recorded separately.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed exposure and the effect of interest for the selected protocol are unverified.
Required materials and conditions: Original Korean/English claim and boundaries from multicomponent/parent context
Materials to obtain first: Detailed exposure and the effect of interest for the selected protocol are unverified.
Further research: Material needed: Detailed exposure and the effect of interest for the selected protocol are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original Korean/English claim and boundaries from multicomponent/parent context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original Korean/English claim and boundaries from multicomponent/parent context with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N02 · Are subclaim D and parent C46 distinguished?

Current findings: The original subclaim grade is D, with note that primary AHI was null in two small trials. Subclaim score/status are absent. Parent C46 is a historical verdict covering conflicting programs/endpoints, not a new subclaim score.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Subclaim score/status fields are absent from the original. Parent values are not copied to fill them.
Required materials and conditions: Original subclaim D/note and absent score/status
Materials to obtain first: Subclaim score/status fields are absent from the original. Parent values are not copied to fill them.
Further research: Material needed: Subclaim score/status fields are absent from the original. Parent values are not copied to fill them. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original subclaim D/note and absent score/status must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original subclaim D/note and absent score/status with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N03 · Are Poncin and Yoshioka populations the same?

Current findings: Poncin bibliography concerns OSA patients; Yoshioka concerns mild-to-moderate sleep-disordered breathing. The parent has adult context. Exact ages, diagnoses, severity, baseline AHI, weight, exclusions and concurrent therapies for each tongue trial are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific eligibility, diagnoses, baseline AHI, risks, ages and concurrent-treatment material are needed.
Required materials and conditions: OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity
Materials to obtain first: Report-specific eligibility, diagnoses, baseline AHI, risks, ages and concurrent-treatment material are needed.
Further research: Material needed: Report-specific eligibility, diagnoses, baseline AHI, risks, ages and concurrent-treatment material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects OSA, mild-to-moderate sleep-disordered breathing, eligibility and severity with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N04 · Are tongue elevation, device resistance and multicomponent exercise the same intervention?

Current findings: The original separates six-week sham-controlled tongue elevation, eight-week device-based tongue resistance with no-intervention control and three-month multicomponent oropharyngeal exercise. Retain the original boundary that muscles, components, supervision, tools and adherence define different interventions.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Protocol-specific intensity, repetitions, tools, supervision and actual adherence are unverified.
Required materials and conditions: Muscles, components, supervision, tools and adherence
Materials to obtain first: Protocol-specific intensity, repetitions, tools, supervision and actual adherence are unverified.
Further research: Material needed: Protocol-specific intensity, repetitions, tools, supervision and actual adherence are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Muscles, components, supervision, tools and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Muscles, components, supervision, tools and adherence with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N05 · What comparisons do sham and no intervention represent?

Current findings: Distinguish tongue-only sham and no-intervention controls. Actual sham movements, contact time, concurrent standard therapy, medicines, other interventions and care-difference details are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Sham components, no-intervention conditions, contact, concurrent therapy and equal-care material are needed.
Required materials and conditions: Sham movements, contact, time, concurrent therapies and shared care
Materials to obtain first: Sham components, no-intervention conditions, contact, concurrent therapy and equal-care material are needed.
Further research: Material needed: Sham components, no-intervention conditions, contact, concurrent therapy and equal-care material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Sham movements, contact, time, concurrent therapies and shared care must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Sham movements, contact, time, concurrent therapies and shared care with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N06 · Which programs lasted six weeks, eight weeks and three months?

Current findings: Preserve original correspondence between Poncin six weeks, Yoshioka eight weeks, Guimarães three months and their samples. Actual assessment dates, discontinuation, later follow-up and exact adherence durations are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact assessment, actual exposure, discontinuation and later-follow-up material are needed.
Required materials and conditions: Report-specific duration, assessment, exposure and later follow-up
Materials to obtain first: Exact assessment, actual exposure, discontinuation and later-follow-up material are needed.
Further research: Material needed: Exact assessment, actual exposure, discontinuation and later-follow-up material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific duration, assessment, exposure and later follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific duration, assessment, exposure and later follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N07 · How was tongue-only primary AHI measured and analyzed?

Current findings: The original combined tongue summary describes primary AHI and null between-group results in two trials. Exact tongue-only AHI values, units, devices, scoring, baseline/change values, models and denominators are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Report-specific AHI definitions, measurement, original values, units, baselines, denominators and models are needed.
Required materials and conditions: AHI definition, units, measurement, original values, denominators and models
Materials to obtain first: Report-specific AHI definitions, measurement, original values, units, baselines, denominators and models are needed.
Further research: Material needed: Report-specific AHI definitions, measurement, original values, units, baselines, denominators and models are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for AHI definition, units, measurement, original values, denominators and models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects AHI definition, units, measurement, original values, denominators and models with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N08 · What was the original Poncin primary AHI result?

Current findings: The original and its citation record null between-group primary AHI in Poncin. Exact Poncin arm AHI values, comparative estimates, P values, 95% CIs, denominators and models are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact Poncin effects, P values, CIs, arm denominators and models are needed. Yoshioka values are not copied.
Required materials and conditions: Null comparative AHI, hierarchy, effects, CIs and denominators
Materials to obtain first: Exact Poncin effects, P values, CIs, arm denominators and models are needed. Yoshioka values are not copied.
Further research: Material needed: Exact Poncin effects, P values, CIs, arm denominators and models are needed. Yoshioka values are not copied. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Null comparative AHI, hierarchy, effects, CIs and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Null comparative AHI, hierarchy, effects, CIs and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02

N09 · Are secondary ESS and tongue endurance distinguished from AHI?

Current findings: The original citation records Poncin primary AHI null and secondary ESS positive. Broad parent wording states that positive ESS/tongue endurance were secondary to failed primary AHI. Exact values, report-specific endurance attribution and measurement are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original ESS/endurance values, CIs, units, denominators and exact report attribution of endurance are needed.
Required materials and conditions: Poncin ESS, broad endurance wording, hierarchy and attribution
Materials to obtain first: Original ESS/endurance values, CIs, units, denominators and exact report attribution of endurance are needed.
Further research: Material needed: Original ESS/endurance values, CIs, units, denominators and exact report attribution of endurance are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Poncin ESS, broad endurance wording, hierarchy and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Poncin ESS, broad endurance wording, hierarchy and attribution with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N10 · What is the scope of Yoshioka AHI P=.44?

Current findings: Preserve Yoshioka AHI P=.44 and null comparative wording in the original, combined summary and citation. Exact arm AHI values, effects, CIs, denominators and models are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Yoshioka arm AHI original values, effects, CIs, denominators and models are needed.
Required materials and conditions: Original null comparative AHI, P value, effects and denominators
Materials to obtain first: Yoshioka arm AHI original values, effects, CIs, denominators and models are needed.
Further research: Material needed: Yoshioka arm AHI original values, effects, CIs, denominators and models are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original null comparative AHI, P value, effects and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original null comparative AHI, P value, effects and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R03

N11 · What separate result does ESS P=.62 represent?

Current findings: The original and citation specify Yoshioka ESS P=.62. It differs from positive Poncin secondary ESS and is a separate endpoint from AHI. Original ESS values, effects, CIs, denominators, prior hierarchy and timing details are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact ESS values, effects, CIs, denominators, plans and times are needed.
Required materials and conditions: Yoshioka ESS, times, denominators and separation from AHI
Materials to obtain first: Exact ESS values, effects, CIs, denominators, plans and times are needed.
Further research: Material needed: Exact ESS values, effects, CIs, denominators, plans and times are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Yoshioka ESS, times, denominators and separation from AHI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Yoshioka ESS, times, denominators and separation from AHI with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R03

N12 · Are within-group AHI values from the 31-person multicomponent trial the selected effect?

Current findings: Distinguish Guimarães exercise-group AHI 22.4±4.8 to 13.7±8.5/h from unavailable exact between-group change and 95% CI. This is background from a 31-person three-month multicomponent program, not a direct tongue-only effect.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Exact multicomponent comparative change, CI, meaning of ±, arm denominators and models are unverified.
Required materials and conditions: Multicomponent exercise-group values and missing comparative estimates
Materials to obtain first: Exact multicomponent comparative change, CI, meaning of ±, arm denominators and models are unverified.
Further research: Material needed: Exact multicomponent comparative change, CI, meaning of ±, arm denominators and models are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Multicomponent exercise-group values and missing comparative estimates must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Multicomponent exercise-group values and missing comparative estimates with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N13 · How are multicomponent registered primary AHI and retrospective-registration wording retained?

Current findings: The original multicomponent evidence row records registered primary AHI; its citation contains NCT00660777 and historical retrospective-registration checking wording. Exact registration dates, recruitment order and original plans remain unread and do not replace tongue-only plans.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original multicomponent registration content, dates, plans, changes and recruitment order are needed.
Required materials and conditions: Guimarães NCT00660777, original hierarchy and registration timing
Materials to obtain first: Original multicomponent registration content, dates, plans, changes and recruitment order are needed.
Further research: Material needed: Original multicomponent registration content, dates, plans, changes and recruitment order are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Guimarães NCT00660777, original hierarchy and registration timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Guimarães NCT00660777, original hierarchy and registration timing with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01

N14 · Do tongue strength/endurance, sleepiness and snoring answer AHI?

Current findings: The original does not convert tongue strength, sleepiness or snoring into AHI success. Broad secondary-positive wording is retained separately from AHI; direct mediation and clinical links remain unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Original values, measurement, hierarchy and AHI/clinical mediation links for each measure are needed.
Required materials and conditions: Measure definitions, units, primary/secondary hierarchy and clinical links
Materials to obtain first: Original values, measurement, hierarchy and AHI/clinical mediation links for each measure are needed.
Further research: Material needed: Original values, measurement, hierarchy and AHI/clinical mediation links for each measure are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Measure definitions, units, primary/secondary hierarchy and clinical links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Measure definitions, units, primary/secondary hierarchy and clinical links with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N15 · What is the scope of app scores and snoring signals?

Current findings: Retain the original boundary that 'reduced app snoring = reduced AHI' lacks direct evidence. Detailed bibliography/quantification for symptom signals in other snoring trials is unverified; hypothetical reports are not added.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: App/snoring original-report identity, measurement, values and direct AHI links are needed.
Required materials and conditions: Actual reports, measurement and direct AHI links
Materials to obtain first: App/snoring original-report identity, measurement, values and direct AHI links are needed.
Further research: Material needed: App/snoring original-report identity, measurement, values and direct AHI links are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Actual reports, measurement and direct AHI links must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Actual reports, measurement and direct AHI links with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N16 · What are exact tongue-only effects, CIs and effects of interest?

Current findings: Null comparative AHI wording for two tongue trials and Yoshioka P values are present, but exact effects of interest, adjustments, 95% CIs, minimal important differences and equivalence designs are unverified. Retain the original boundary that small null trials do not establish null effects for every exercise.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Effects, CIs, effects of interest, adjustment, importance and equivalence plans are needed.
Required materials and conditions: Comparative estimation, adjustment, CIs, models and clinical importance
Materials to obtain first: Effects, CIs, effects of interest, adjustment, importance and equivalence plans are needed.
Further research: Material needed: Effects, CIs, effects of interest, adjustment, importance and equivalence plans are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Comparative estimation, adjustment, CIs, models and clinical importance must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Comparative estimation, adjustment, CIs, models and clinical importance with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N17 · What uncertainty remains with small samples of 27 and 20?

Current findings: The parent identifies small studies and missing quantification as limitations. Original samples of 27 and 20 do not confirm precise null effects or universally rule out treatment effects; CIs and sample-size plans are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: AHI intervals, sample-size justification, power, importance and observation losses are needed.
Required materials and conditions: Endpoint denominators, intervals, power and follow-up
Materials to obtain first: AHI intervals, sample-size justification, power, importance and observation losses are needed.
Further research: Material needed: AHI intervals, sample-size justification, power, importance and observation losses are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Endpoint denominators, intervals, power and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Endpoint denominators, intervals, power and follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N18 · What do 27 and 20 represent in each report?

Current findings: The original records multicomponent 31, six-week 27 and eight-week 20 separately; the combined tongue row records 27 and 20. Arm allocation, completion, analysis and AHI/ESS/strength denominators in each tongue trial are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Arm allocation, completion, analysis, endpoint denominators and exclusions are needed.
Required materials and conditions: Original participants, arm allocation, completion and endpoint denominators
Materials to obtain first: Arm allocation, completion, analysis, endpoint denominators and exclusions are needed.
Further research: Material needed: Arm allocation, completion, analysis, endpoint denominators and exclusions are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original participants, arm allocation, completion and endpoint denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original participants, arm allocation, completion and endpoint denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N19 · How does Yoshioka completer analysis relate to missingness?

Current findings: The original Yoshioka citation marks 20 participants and completer analysis. Total allocation, arm completion/analysis, discontinuation, exclusions, AHI/ESS missing-data handling and Poncin flow details are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Allocation, completion, arm losses, exclusions and measure-specific missingness/handling are needed.
Required materials and conditions: Allocation, completion, discontinuation, exclusions and endpoint missingness
Materials to obtain first: Allocation, completion, arm losses, exclusions and measure-specific missingness/handling are needed.
Further research: Material needed: Allocation, completion, arm losses, exclusions and measure-specific missingness/handling are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Allocation, completion, discontinuation, exclusions and endpoint missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Allocation, completion, discontinuation, exclusions and endpoint missingness with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N20 · How much is known about random-sequence generation and concealment?

Current findings: The combined tongue summary and bibliography of both tongue reports record randomized trials. Actual generation, concealment, recruitment order, arm allocation, baseline risks and implementation are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual random-sequence generation, concealment, recruitment, allocation and baseline-risk procedures are needed.
Required materials and conditions: Original randomized designs and actual generation, recruitment and allocation
Materials to obtain first: Actual random-sequence generation, concealment, recruitment, allocation and baseline-risk procedures are needed.
Further research: Material needed: Actual random-sequence generation, concealment, recruitment, allocation and baseline-risk procedures are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original randomized designs and actual generation, recruitment and allocation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original randomized designs and actual generation, recruitment and allocation with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N21 · What level of sham, participant and assessor masking is known?

Current findings: Distinguish Poncin sham from Yoshioka no intervention. Allocation awareness among participants, instructors, measurers and analysts, equal contact, sham movements, tools and measurement procedures are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Masking, allocation awareness, sham content, contact, measurement and analysis procedures are needed.
Required materials and conditions: Contact, allocation awareness, measurement and analysis procedures
Materials to obtain first: Masking, allocation awareness, sham content, contact, measurement and analysis procedures are needed.
Further research: Material needed: Masking, allocation awareness, sham content, contact, measurement and analysis procedures are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Contact, allocation awareness, measurement and analysis procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Contact, allocation awareness, measurement and analysis procedures with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N22 · Are baseline AHI, severity, weight and analysis distinguished?

Current findings: Exact tongue-only baseline AHI/ESS, severity, weight, arm balance and baseline handling/adjustment are unverified. Original within-group Guimarães 22.4 is not a tongue-only baseline.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Tongue-only baselines, covariates, balance, adjustment and models are needed.
Required materials and conditions: Tongue-trial baselines, balance, covariates and adjustment
Materials to obtain first: Tongue-only baselines, covariates, balance, adjustment and models are needed.
Further research: Material needed: Tongue-only baselines, covariates, balance, adjustment and models are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Tongue-trial baselines, balance, covariates and adjustment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Tongue-trial baselines, balance, covariates and adjustment with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N23 · How were standard therapy, other care and training compared?

Current findings: The original summary records tongue-only/control programs, but details of concurrent standard therapy, other care, weight/treatment changes and model handling are unverified. Retain the original boundary that symptoms alone cannot determine treatment need.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Standard therapy, concurrent treatment, care, weight changes and analysis handling are needed.
Required materials and conditions: Concurrent therapies, comparators, weight changes, treatment changes and analysis
Materials to obtain first: Standard therapy, concurrent treatment, care, weight changes and analysis handling are needed.
Further research: Material needed: Standard therapy, concurrent treatment, care, weight changes and analysis handling are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Concurrent therapies, comparators, weight changes, treatment changes and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Concurrent therapies, comparators, weight changes, treatment changes and analysis with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N24 · How are actual adherence, tools and intensity linked to results?

Current findings: The original states that muscles, components, supervision, tools and adherence define different interventions. Actual resistance, frequency, instruction, missed sessions, discontinuation and exposure-specific effects in the tongue trials are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Actual intensity, frequency, adherence, supervision, discontinuation, exposure and analysis material are needed.
Required materials and conditions: Planned/actual exposure, resistance, supervision, discontinuation and analysis
Materials to obtain first: Actual intensity, frequency, adherence, supervision, discontinuation, exposure and analysis material are needed.
Further research: Material needed: Actual intensity, frequency, adherence, supervision, discontinuation, exposure and analysis material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Planned/actual exposure, resistance, supervision, discontinuation and analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Planned/actual exposure, resistance, supervision, discontinuation and analysis with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N25 · What are allocation, completer and actual-use effects and missing-data handling?

Current findings: Beyond original Yoshioka completer wording, ITT/PP, actual use, missingness, imputation, sensitivity, models and covariates in each tongue trial are unverified. Original comparative null wording is retained only within original-report scope.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: ITT/PP, actual use, models, adjustment, missingness and sensitivity material are needed.
Required materials and conditions: ITT/PP, adjustment, missingness, sensitivity and repeated measures
Materials to obtain first: ITT/PP, actual use, models, adjustment, missingness and sensitivity material are needed.
Further research: Material needed: ITT/PP, actual use, models, adjustment, missingness and sensitivity material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for ITT/PP, adjustment, missingness, sensitivity and repeated measures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects ITT/PP, adjustment, missingness, sensitivity and repeated measures with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N26 · What do NCT/UMIN identifiers and the original primary hierarchy establish?

Current findings: Original tongue bibliography includes NCT03846349 and UMIN000041489; original evidence/citations record null primary AHI. Current registration content, dates, recruitment order, changes and analysis plans remain unread.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Registration content, dates, plans, hierarchy, analysis, recruitment order and change history are needed.
Required materials and conditions: Tongue-report registration, protocols, primary AHI and secondary outcomes
Materials to obtain first: Registration content, dates, plans, hierarchy, analysis, recruitment order and change history are needed.
Further research: Material needed: Registration content, dates, plans, hierarchy, analysis, recruitment order and change history are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Tongue-report registration, protocols, primary AHI and secondary outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Tongue-report registration, protocols, primary AHI and secondary outcomes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N27 · How are tongue-only null results and multicomponent signals preserved together?

Current findings: The parent did not combine programs into blanket benefit or null conclusions. Retain separate scopes of multicomponent within-group signals, tongue-only primary null results and symptoms/strength/endurance; small null trials do not establish null effects for every possible exercise.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Direct comparisons under the same conditions, effects, CIs, independence and quantitative links are unverified.
Required materials and conditions: Each comparator, duration, components, endpoints and quantification
Materials to obtain first: Direct comparisons under the same conditions, effects, CIs, independence and quantitative links are unverified.
Further research: Material needed: Direct comparisons under the same conditions, effects, CIs, independence and quantitative links are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Each comparator, duration, components, endpoints and quantification must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Each comparator, duration, components, endpoints and quantification with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N28 · How do two evidence groups, three bibliographies and historical five RCTs differ?

Current findings: The original contains two evidence rows and three citations. The parent decision historically describes five RCTs/registry cross-checking, but the full list and additional-report details are unverified. Link the combined tongue summary within each of two separate bibliographies; no hypothetical reports are added.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Related/additional reports, cohort overlap and unique-trial/participant totals are unverified.
Required materials and conditions: Combined summaries, individual bibliography, historical study counts and cohorts
Materials to obtain first: Related/additional reports, cohort overlap and unique-trial/participant totals are unverified.
Further research: Material needed: Related/additional reports, cohort overlap and unique-trial/participant totals are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Combined summaries, individual bibliography, historical study counts and cohorts must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Combined summaries, individual bibliography, historical study counts and cohorts with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N29 · Which trial and roles do public/university support and device provision concern?

Current findings: The original multicomponent row records limited funding verification; the combined tongue row records public/university support and device provision in one trial. Which trial received the device, and support, COI, design/analysis roles and independence details, are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Individual attribution of support/device provision, COI, roles, research families and independence material are needed.
Required materials and conditions: Report-specific support, COI, devices, design, analysis and independence
Materials to obtain first: Individual attribution of support/device provision, COI, roles, research families and independence material are needed.
Further research: Material needed: Individual attribution of support/device provision, COI, roles, research families and independence material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Report-specific support, COI, devices, design, analysis and independence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Report-specific support, COI, devices, design, analysis and independence with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N30 · Do the studies answer post-training AHI and clinical outcomes?

Current findings: There is assessment context for six/eight-week tongue programs, but post-training AHI, clinical events, other durations/intensities/subgroups and standard-treatment-replacement material are unverified. Retain the original boundary that symptoms alone cannot determine severity or treatment need.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Later follow-up, clinical outcomes, other conditions, subgroups and treatment-change material are needed.
Required materials and conditions: Later follow-up, other conditions, subgroups and treatment changes
Materials to obtain first: Later follow-up, clinical outcomes, other conditions, subgroups and treatment-change material are needed.
Further research: Material needed: Later follow-up, clinical outcomes, other conditions, subgroups and treatment-change material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Later follow-up, other conditions, subgroups and treatment changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Later follow-up, other conditions, subgroups and treatment changes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N31 · What material was actually read here?

Current findings: The complete stored parent 2992 summary and original bibliography were used and originals preserved. The three reports were read as summaries; external abstracts, full texts, registration, plans and support material remain unread without access attempts. The 24 material slots comprise three stored summaries and 21 unread/needed external-material slots.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: External originals remain unread. Access failure or inaccessibility was not established either.
Required materials and conditions: Complete stored summary/bibliography versus external originals
Materials to obtain first: External originals remain unread. Access failure or inaccessibility was not established either.
Further research: Material needed: External originals remain unread. Access failure or inaccessibility was not established either. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Complete stored summary/bibliography versus external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Complete stored summary/bibliography versus external originals with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N32 · Are historical cross-checking and current review distinguished?

Current findings: Retain original 2026-09-07, an empty corrections array and empty deliberation string. Historical checking of five RCTs, registration and primary outcomes is a parent history record, not completed current review.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Current content-review and new clinical-verification dates are unrecorded; review of existing content remains incomplete.
Required materials and conditions: Original date, empty corrections/deliberation and historical decision
Materials to obtain first: Current content-review and new clinical-verification dates are unrecorded; review of existing content remains incomplete.
Further research: Material needed: Current content-review and new clinical-verification dates are unrecorded; review of existing content remains incomplete. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original date, empty corrections/deliberation and historical decision must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original date, empty corrections/deliberation and historical decision with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N33 · Are original Korean/English tongue-only, multicomponent, primary and symptom boundaries retained?

Current findings: The original English subclaim is 'AHI improvement from isolated tongue resistance training', with note that primary AHI was null in two small trials. Parent English also distinguishes multicomponent/tongue-only and primary outcomes/symptoms/strength. No detailed external comparison was performed.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Detailed translation/correction comparisons between external papers and original Korean/English remain unverified.
Required materials and conditions: Original subclaim/note, parent Korean/English and safety
Materials to obtain first: Detailed translation/correction comparisons between external papers and original Korean/English remain unverified.
Further research: Material needed: Detailed translation/correction comparisons between external papers and original Korean/English remain unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Original subclaim/note, parent Korean/English and safety must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Original subclaim/note, parent Korean/English and safety with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N34 · How are parent axes and failed primary/positive secondary outcomes retained?

Current findings: Parent axes are B/S/R0/I1/EX/B2/CX; the primary-failed-secondary-positive flag is true. Coprimary split, large hard-endpoint RCT and no-human-study flags are false. Derived grade is C; override is an empty string. Subclaim score, status and axes are absent from the original.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Selected-subclaim score, status and axes are absent; details of each original endpoint plan are unverified.
Required materials and conditions: Parent axes, original flags and absent subclaim axes
Materials to obtain first: Selected-subclaim score, status and axes are absent; details of each original endpoint plan are unverified.
Further research: Material needed: Selected-subclaim score, status and axes are absent; details of each original endpoint plan are unverified. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Parent axes, original flags and absent subclaim axes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Parent axes, original flags and absent subclaim axes with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources

N35 · Which trial does the one mucosal-abrasion participant belong to?

Current findings: The original safety wording records one exercise-arm participant in a tongue-training trial temporarily stopping because of an oral mucosal abrasion, then resuming. Exact trial attribution, definition, collection, adjudication and denominators are unverified in the current summary.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Trial attribution, definitions, collection, adjudication, exposure and observation denominators for the abrasion are needed.
Required materials and conditions: Event attribution, definition, collection, adjudication and denominator
Materials to obtain first: Trial attribution, definitions, collection, adjudication, exposure and observation denominators for the abrasion are needed.
Further research: Material needed: Trial attribution, definitions, collection, adjudication, exposure and observation denominators for the abrasion are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Event attribution, definition, collection, adjudication and denominator must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Event attribution, definition, collection, adjudication and denominator with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N36 · What are abrasion onset, stopping/resumption and follow-up times?

Current findings: The original records resumption after temporary discontinuation. Exposure, onset, recovery, discontinuation duration, recurrence, later harm follow-up and exact trial attribution are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Event, recovery, discontinuation duration, recurrence and later-follow-up times are needed.
Required materials and conditions: Actual exposure, onset, recovery, stopping, recurrence and follow-up
Materials to obtain first: Event, recovery, discontinuation duration, recurrence and later-follow-up times are needed.
Further research: Material needed: Event, recovery, discontinuation duration, recurrence and later-follow-up times are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Actual exposure, onset, recovery, stopping, recurrence and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Actual exposure, onset, recovery, stopping, recurrence and follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N37 · Were harms collected equally in sham/no-intervention groups?

Current findings: Tongue-only sham/no-intervention comparisons exist, but equal harm collection, observation periods, control event counts/denominators, comparative risks and attribution of the one participant are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Equal harm collection/observation, control events, denominators and comparative material are needed.
Required materials and conditions: Arm collection, observation, control events and denominators
Materials to obtain first: Equal harm collection/observation, control events, denominators and comparative material are needed.
Further research: Material needed: Equal harm collection/observation, control events, denominators and comparative material are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Arm collection, observation, control events and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Arm collection, observation, control events and denominators with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N38 · Are exposure/observation denominators and abrasion frequency known?

Current findings: The original describes one abrasion participant, but exposure/observation denominators, arm/trial attribution, total harms and missingness are unverified. Original samples of 27 and 20 are not that harm denominator.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm attribution, exposure, follow-up, arm denominators and total harm counts are needed. No new frequencies or risks are calculated.
Required materials and conditions: Exact trial/arm, actual exposure, follow-up, harms and discontinuation
Materials to obtain first: Harm attribution, exposure, follow-up, arm denominators and total harm counts are needed. No new frequencies or risks are calculated.
Further research: Material needed: Harm attribution, exposure, follow-up, arm denominators and total harm counts are needed. No new frequencies or risks are calculated. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Exact trial/arm, actual exposure, follow-up, harms and discontinuation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Exact trial/arm, actual exposure, follow-up, harms and discontinuation with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N39 · Are tools, training, baseline conditions and event causes distinguished?

Current findings: Original mucosal-abrasion/temporary-stopping wording exists, but tool/program attribution, actual exposure, baseline conditions, concurrent care, timing and causal-adjudication details are unverified.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Tools, exposure, baseline conditions, event attribution, timing and causal assessment are needed.
Required materials and conditions: Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause
Materials to obtain first: Tools, exposure, baseline conditions, event attribution, timing and causal assessment are needed.
Further research: Material needed: Tools, exposure, baseline conditions, event attribution, timing and causal assessment are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Tools, actual exposure, baseline oral conditions/disease, concurrent care and cause with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N40 · What are stopping, completer analysis and losses to harm follow-up?

Current findings: Temporary stopping/resumption and Yoshioka completer analysis are separate original records. Arm-specific stopping/losses, missing or selected harm reporting and later follow-up in each report are unverified. The two statements are not linked as the same trial/participant.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Harm-related stopping, losses, missingness, selective reporting and follow-up losses are needed.
Required materials and conditions: Event stopping/resumption, losses, harm missingness and selective reporting
Materials to obtain first: Harm-related stopping, losses, missingness, selective reporting and follow-up losses are needed.
Further research: Material needed: Harm-related stopping, losses, missingness, selective reporting and follow-up losses are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Event stopping/resumption, losses, harm missingness and selective reporting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Event stopping/resumption, losses, harm missingness and selective reporting with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R02 R03

N41 · What is known about other populations, independent reports and later harms?

Current findings: Stored scope covers program-specific AHI/symptoms and one abrasion participant with unverified attribution. Independent harm reports under the same protocol, other severities/disease populations and post-training observation are unverified.
Verification status: Unverified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Independent harm material, vulnerable/severe populations and post-training follow-up are needed.
Required materials and conditions: Same protocol, vulnerable populations, severity and long-term follow-up
Materials to obtain first: Independent harm material, vulnerable/severe populations and post-training follow-up are needed.
Further research: Material needed: Independent harm material, vulnerable/severe populations and post-training follow-up are needed. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Same protocol, vulnerable populations, severity and long-term follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Same protocol, vulnerable populations, severity and long-term follow-up with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources R01 R02 R03

N42 · Are criteria/original preservation distinguished from content review?

Current findings: Preserved methodology, claim-type conditions and review-scope material were referenced. Condition freezing and separate observation application are distinguished from actual original-material reading/content review. Existing content review remains incomplete; this does not establish official-method certification or new clinical verification.
Verification status: Partly verified
Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread
Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.
Reason for missing information: Update with records of original material, condition versions, separate application, change history and actual review scope.
Required materials and conditions: Preserved methodology, condition versions, separate application and actual review scope
Materials to obtain first: Update with records of original material, condition versions, separate application, change history and actual review scope.
Further research: Material needed: Update with records of original material, condition versions, separate application, change history and actual review scope. This records needed materials; no new research was executed.
Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.
Conditions for verification: Material for Preserved methodology, condition versions, separate application and actual review scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.
Why this condition is needed: This condition connects Preserved methodology, condition versions, separate application and actual review scope with tongue-only AHI, original grade D, report-specific populations, sham/no-intervention controls, six/eight weeks, primary versus secondary outcomes, denominators and harm attribution.
Application exceptions: Preserve original numbers, P values and study exposure only. Distinguish multicomponent from tongue-only programs, within-group changes from between-group estimates, primary AHI from secondary ESS/function, and each comparator, duration, denominator and combined summary. Retrospective registration/historical checks do not become current reading or certification of prior plans. No new arithmetic, effects, CIs, hypothetical numbers, grades, independence certification, oral/breathing training, standard-treatment replacement or procedure instructions are created.
Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.

Related sources