High-ferritin-target intravenous iron × Hemoglobin-centred response in nondialysis CKD anemia

Required evidence, verification status and materials actually read
Item	AVerification status	BReading scope	CReview item	DCurrent findings	EWhy unverified	FRequired materials and conditions	GFurther research
1	Partly verified	Full text not readStored summary read	N01 · Evidence conditionWhich existing subclaim and question direction does this sheet preserve?Required	The selected stored summary concerns hemoglobin-centred response; the selected question and existing verdict record are distinguished. Parent hemoglobin-verdict and other-subclaim context is retained. No new question, split or verdict is created. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Material retaining the selected subclaim-parent relationship, original question and verdict record is needed and remains subject to user review.	Material retaining the selected subclaim-parent relationship, original question and verdict record.	When additional material becomes available, the existing question scope is recorded separately from other questions.
2	Partly verified	Full text not readStored summary read	N02 · Evidence conditionHow are subclaim grade/note and absent score, status and axes distinguished?Required	The selected subclaim grade is C and its note says the surrogate composite improved. Subclaim score, status and axes are absent from the stored summary, recorded as null and field absence. Parent C, 50 points and axes are not substituted for subclaim values. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Actual selected-subclaim fields and separately retained parent fields is needed and remains subject to user review.	Actual selected-subclaim fields and separately retained parent fields.	If the original subclaim is corrected, the complete pre-change text and change event are preserved.
3	Partly verified	Full text not readStored summary read	N03 · Evidence conditionWhat historical context do parent C, 50 points, axes, safety and empty values represent?Required	Parent C, 50 points and B/S/R1/I0/E+/B2 are preserved. Precision is unrecorded; coprimary splitting, large hard-endpoint RCT and no-human-study flags are false; grade-override reasons are empty in both languages. Parent safety is caution. These values are not inherited as selected-subclaim scores or newly satisfied conditions. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete parent verdict, axes, safety labels and actual change history is needed and remains subject to user review.	Complete parent verdict, axes, safety labels and actual change history.	Even if a new verdict is requested, original grades and production status remain separately preserved.
4	Partly verified	Full text not readStored summary read	N04 · Evidence conditionHow are original Korean/English, reference dates and correction histories retained?Required	Parent and subclaim explanations in Korean/English are linked as originally written. The original reference date is 2026-08-26; corrections are an empty array and deliberation an empty value. Detailed Korean rates and concise English wording do not overwrite each other. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete original text, language-specific explanations, reference dates and additional correction records is needed and remains subject to user review.	Complete original text, language-specific explanations, reference dates and additional correction records.	Added language-specific text or corrections preserve the complete existing version and link as a new event.
5	Partly verified	Full text not readStored summary read	N05 · Evidence conditionWhich materials were actually read for this production and which external materials remain unread?Required	The actual production input is the complete stored summary. Abstracts, full texts, registration, protocols, SAPs and original result tables were not accessed. Research-assessment wording in the summary does not mean current external reading. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Acquisition/reading levels and relevant result locations in original source material is needed and remains subject to user review.	Acquisition/reading levels and relevant result locations in original source material.	Separate additional reading must record its scope and time as a new event.
6	Partly verified	Full text not readStored summary read	N06 · Evidence conditionWhat are the FIND-CKD report bibliography and registration identity?Required	The stored direct report is Macdougall IC et al., 2014 FIND-CKD, linked to PMID 24891437 and NCT00994318. DOI, PMCID and external registration content are unverified. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Paper bibliography, original full text, registration content and their actual links is needed and remains subject to user review.	Paper bibliography, original full text, registration content and their actual links.	Added report identities must be distinguished as the same trial or separate trials using original material.
7	Partly verified	Full text not readStored summary read	N07 · Evidence conditionHow do two subclaim sheets share one trial, report and population?Required	The hemoglobin-response and clinical-event sheets share the same FIND-CKD report/population. Hemoglobin, dialysis, death, infection or two sheets are not added as independent trials/participants. One stored bibliographic entry does not certify a unique trial count. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original material distinguishing trial, report, population, group, outcome links and overlap is needed and remains subject to user review.	Original material distinguishing trial, report, population, group, outcome links and overlap.	New follow-up/related reports link to the existing family; independent replication requires separate material.
8	Partly verified	Full text not readStored summary read	N08 · Evidence conditionWhich nondialysis chronic kidney disease anemia population was studied?Required	The parent question concerns iron-deficiency anemia in nondialysis chronic kidney disease. Results are not automatically transferred to dialysis patients, other anemia causes or preoperative preparation. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria is needed and remains subject to user review.	Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria.	Population differences require direct comparison material for the relevant populations.
9	Unverified	Full text not readStored summary read	N09 · Evidence conditionHow much is verified about baseline risk and representativeness?Supplementary; required for general application	Detailed age, kidney-disease stage, baseline Hb/iron status, comorbidities and group distributions of clinical-event risk are absent from the current summary. A population name does not establish identical responses in all nondialysis patients. R01	Direct details are unverified within the current stored summary and unread external material. Group baseline tables, recruitment pathways, exclusions, severity and comorbidities is needed and remains subject to user review.	Group baseline tables, recruitment pathways, exclusions, severity and comorbidities.	Application to different risk populations must be distinguished using direct studies with follow-up.
10	Partly verified	Full text not readStored summary read	N10 · Evidence conditionWhat are the research conditions for high-ferritin-target intravenous ferric carboxymaltose?Required	The historical high-group ferritin target is 400~600 µg/L. It is a trial strategy condition, not an achieved value or a recommended target. It is not extended to other iron formulations/targets. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Intervention strategy, product identity, target-adjustment rules and group achieved values is needed and remains subject to user review.	Intervention strategy, product identity, target-adjustment rules and group achieved values.	Differences by formulation or target require direct strategy-comparison material.
11	Partly verified	Full text not readStored summary read	N11 · Evidence conditionWhat is the original research exposure of the oral ferrous sulfate control?Required	The original oral control provided 100 mg iron as ferrous sulfate twice daily. This compares an active control with the intravenous-iron strategy; no dosing guidance or dose conversion is created. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Oral formulation, research exposure, actual use, discontinuation and adherence material is needed and remains subject to user review.	Oral formulation, research exposure, actual use, discontinuation and adherence material.	Material with different control conditions is linked separately with those differences specified.
12	Partly verified	Full text not readStored summary read	N12 · Evidence conditionHow are the selected comparison and other-group information separated in the three-arm design?Required	FIND-CKD is a 56-week multicentre randomized open-label three-arm active-control trial. The selected stored comparison is high-ferritin-target intravenous iron versus oral iron; specific targets, group values and exposure of the other intravenous-iron group are absent from the summary. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans is needed and remains subject to user review.	Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans.	Added other-group results retain separate attribution from the current comparison.
13	Unverified	Full text not readStored summary read	N13 · Evidence conditionHow much is known about actual intravenous administration, achieved ferritin, adherence and changes?Required	Intravenous formulation and target strategy are described, but actual doses/frequency, group cumulative exposure, achieved ferritin, oral adherence and changes are unverified in the current summary. R01	Direct details are unverified within the current stored summary and unread external material. Actual group administration, achieved values, adherence, changes and discontinuation records is needed and remains subject to user review.	Actual group administration, achieved values, adherence, changes and discontinuation records.	Exposure differences require material linking actual strategy implementation with outcomes.
14	Partly verified	Full text not readStored summary read	N14 · Evidence conditionAre starting ESA, transfusions or other iron concurrent care or outcome components?Required	Clinician decisions to start ESA, transfusions or other iron entered the primary composite. Actual treatment frequency, criteria and group courses are absent from the summary, requiring concurrent-management and composite-component roles to be distinguished. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Additional-management initiation criteria, group use/timing and outcome-counting rules is needed and remains subject to user review.	Additional-management initiation criteria, group use/timing and outcome-counting rules.	Interpreting additional management requires plans alongside actual courses.
15	Partly verified	Full text not readStored summary read	N15 · Evidence conditionAre 56-week follow-up and the weeks 8~52 composite window the same period?Required	The overall design is 56 weeks; the primary composite Hb window is weeks 8~52. Overall follow-up and outcome-specific counting windows are not merged. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up is needed and remains subject to user review.	Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up.	Added timepoint-specific material links each outcome to its relevant period separately.
16	Partly verified	Full text not readStored summary read	N16 · Evidence conditionWhat are the randomized, ITT and completed denominators?Required	Stored counts of 626 randomized, 613 ITT and 519 completed are distinguished. The stored summary says 519/626 (82.9%) completed and 17.1% did not complete. These denominators are not applied uniformly to all outcomes and exclusions are not newly calculated. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons is needed and remains subject to user review.	Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons.	Added actual analysis inclusion/missingness rules supplement outcome-specific links.
17	Partly verified	Full text not readStored summary read	N17 · Evidence conditionHow are group-denominator differences for the primary composite, death and infection recorded?Required	Primary-composite denominators are high-target 153 and oral 308; original death/infection denominators are 154 and 312. These differ; exact analysis-population definitions and exclusion reasons remain externally unread. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables is needed and remains subject to user review.	Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables.	Original explanations of outcome-specific denominators link only to the corresponding rows.
18	Partly verified	Full text not readStored summary read	N18 · Evidence conditionWhat effects remain uncertain from noncompletion and missingness?Required	The stored assessment retains historical limitations of 17.1% noncompletion and substantial attrition. Group reasons, outcome-specific missingness, imputation and sensitivity analyses cannot be verified from the summary alone. The historical ≥15% category is not run as a new automatic scoring rule. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material is needed and remains subject to user review.	Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material.	Changes under missingness assumptions must be distinguished using original analyses/additional material.
19	Partly verified	Full text not readStored summary read	N19 · Evidence conditionWhat is the verification scope of central randomization?Required	The stored account says central interactive voice-response randomization was used. Actual sequence generation, concealment, stratification and implementation details remain externally unread. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Detailed allocation methods, protocols and implementation material is needed and remains subject to user review.	Detailed allocation methods, protocols and implementation material.	Added allocation procedures must retain known levels separately from unverified details.
20	Partly verified	Full text not readStored summary read	N20 · Evidence conditionWhat distinctions does open-label design require for treatment decisions and laboratory measurement?Required	The original limitation of open-label design and clinician additional-treatment decisions in the primary composite is retained. Laboratory measurement, assessor masking and consistent decision criteria are unverified in detail. No new claim that all Hb tests are inherently subjective is made. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations is needed and remains subject to user review.	Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations.	Material separating component measurement from decision procedures is needed.
21	Unverified	Full text not readStored summary read	N21 · Evidence conditionWas NCT00994318 registration content actually verified?Required	NCT00994318 is retained as the existing registration identifier. Registration was not opened here; initial registration date, prespecified endpoints, amendments, posted results and paper comparisons remain unverified. R01	Direct details are unverified within the current stored summary and unread external material. Original registration text, versions, endpoints, analyses and changes is needed and remains subject to user review.	Original registration text, versions, endpoints, analyses and changes.	Separately acquired registration material must retain its version and relationship to reports.
22	Partly verified	Full text not readStored summary read	N22 · Evidence conditionAt what level are primary/secondary endpoint and analysis hierarchies known?Required	The parent explanation distinguishes the other-anemia-management/consecutive-low-Hb composite as the exact primary endpoint. Prespecified plans, multiplicity and analysis hierarchy for Hb rise and clinical/safety events remain unread in registration, protocols and SAPs. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables is needed and remains subject to user review.	Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables.	Added plans link prespecified and post hoc distinctions to each outcome.
23	Partly verified	Full text not readStored summary read	N23 · Evidence conditionWhat original information describes Vifor Pharma sponsorship and oral-iron supply?Required	Stored material specifies Vifor Pharma sponsorship and oral-iron supply. Parent manufacturer-single-trial assessment remains historical. Sponsorship alone does not trigger a new verdict invalidating results. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles is needed and remains subject to user review.	Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles.	Added sponsorship, data-access or analysis-involvement information is recorded separately from interpretation limits.
24	Unverified	Full text not readStored summary read	N24 · Evidence conditionWhat are the detailed author conflicts, data-access and publication roles?Supplementary; required for independence claims	Beyond summarized sponsorship/product supply, detailed author conflicts, contracts, data-access/analysis independence and publication decisions are unverified. Unverified information is not changed to absence of conflicts. R01	Direct details are unverified within the current stored summary and unread external material. COI, sponsorship contracts, analysis, data-access and publication-role disclosures is needed and remains subject to user review.	COI, sponsorship contracts, analysis, data-access and publication-role disclosures.	Added independent reports first distinguish actual parties, data sharing and analysis relationships.
25	Partly verified	Full text not readStored summary read	N25 · Evidence conditionWhat safety scope do stored infection observations cover?Required	Infections were high-target 51/154 (33.1%) versus oral 95/312 (30.4%). Historical wording describing similar infection events is retained alongside inadequate safety power. No absence of increased risk is established. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power is needed and remains subject to user review.	Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power.	Clinically important infection harms require appropriate event collection, follow-up and comparisons.
26	Unverified	Full text not readStored summary read	N26 · Evidence conditionAre detailed safety collection, sparse events and attrition verified?Required	Some infection, death and dialysis values exist, but detailed collection methods, recurrent-event handling, assessors, period-specific missingness, severity and original safety tables are unverified. No attempted access is not changed to nonreporting or inaccessibility. R01	Direct details are unverified within the current stored summary and unread external material. Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up is needed and remains subject to user review.	Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up.	Safety signals require material with definitions, ascertainment, denominators and follow-up.
27	Unverified	Full text not readStored summary read	N27 · Evidence conditionWhat harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors?Supplementary; required for long-term/safety extension	Results in the selected 56-week population are not extended to long-term/rare harms or safety in other kidney-disease states. Detailed links among baseline disease, concurrent care, treatment selection and events are absent, so sole causation or harmlessness cannot be established. R01	Direct details are unverified within the current stored summary and unread external material. Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events is needed and remains subject to user review.	Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events.	Long-term/rare clinical harms need separate material with sufficient follow-up and appropriate comparisons.
28	Partly verified	Full text not readStored summary read	N28 · Evidence conditionIs preoperative verdict 2560 for the same drug direct evidence here?Supplementary; required for limits of extension to other settings	Existing citation 2560 concerns preoperative intravenous ferric carboxymaltose and transfusion/death in a different setting, linked as historical D, 34 points. It is not added as direct nondialysis chronic-anemia evidence or a new independent trial entry. That page remains unread.	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Direct material and application limits for different use settings, populations, timepoints and clinical outcomes is needed and remains subject to user review.	Direct material and application limits for different use settings, populations, timepoints and clinical outcomes.	Material from other settings is not merged by drug name alone; question/population differences remain recorded.
29	Partly verified	Full text not readStored summary read	N29 · Evidence conditionWhat is the exact primary composite for hemoglobin-centred response?Required	The stored primary endpoint is initiation of other anemia management or consecutive Hb <10 g/dL during weeks 8~52, rather than simply Hb-rise response. The subclaim title and actual composite definition remain side by side. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Exact composite plans, components, event-counting and first-event rules is needed and remains subject to user review.	Exact composite plans, components, event-counting and first-event rules.	Original material separating composite definitions from component-specific effects is needed.
30	Partly verified	Full text not readStored summary read	N30 · Evidence conditionWhat are the primary-composite group events, denominators, HR and CI?Required	The primary composite is stored as high-target 36/153 (23.5%) versus oral 98/308 (31.8%), HR 0.65 (95% CI 0.44~0.95). These are between-group composite values, not dialysis, mortality or cardiovascular HRs. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original composite tables, analysis populations, time models, CIs and covariate handling is needed and remains subject to user review.	Original composite tables, analysis populations, time models, CIs and covariate handling.	Material with different estimands or analysis populations is shown separately.
31	Partly verified	Full text not readStored summary read	N31 · Evidence conditionHow do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ?Required	The original composite concerns reduced additional-treatment/consecutive-low-Hb events, with HR 0.65. Hb ≥1 g/dL rise is a separate outcome with HR 2.04. HRs for different event definitions/directions are not changed into the same response rate or clinical efficacy. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Event definitions, origins, models, denominators and interpretation targets for each HR is needed and remains subject to user review.	Event definitions, origins, models, denominators and interpretation targets for each HR.	Added analysis definitions link each outcome to its estimand separately.
32	Partly verified	Full text not readStored summary read	N32 · Evidence conditionWhat original scope do the absolute difference and NNT concern?Required	The stored composite absolute difference is -8.3%p and NNT is 12. These remain within the original composite/comparison/period context without new calculations; they are not displayed as survival/dialysis-benefit counts. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT is needed and remains subject to user review.	Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT.	Added original explanations supplement the application scope of existing values.
33	Partly verified	Full text not readStored summary read	N33 · Evidence conditionWhat are the count, measurement window and test conditions for consecutive Hb <10 g/dL?Required	Korean consecutive Hb <10 g/dL wording and English two consecutive Hb values below 10 g/dL are preserved. The window is weeks 8~52 and < is not changed to another inequality. Actual test intervals, specimens, equipment and confirmation rules are unverified. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness is needed and remains subject to user review.	Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness.	Added measurement plans link the actual rules for two consecutive values.
34	Partly verified	Full text not readStored summary read	N34 · Evidence conditionHow was the additional-treatment-initiation component measured and decided?Required	The original limitation is that clinician decisions to start ESA, transfusions or other iron entered the open-label composite. Group initiation criteria, frequencies, first-event timing and component effects are unverified. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Component-specific initiation criteria, adjudication, group events, denominators and effects is needed and remains subject to user review.	Component-specific initiation criteria, adjudication, group events, denominators and effects.	Composite contents require material presenting treatment decisions and repeated-Hb criteria separately.
35	Partly verified	Full text not readStored summary read	N35 · Evidence conditionWhat are the reported Hb ≥1 g/dL rise-response values?Required	Hb ≥1 g/dL response HR is 2.04 (95% CI 1.52~2.72). It is retained as the original laboratory-response outcome; this HR is not direct dialysis/survival benefit. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original tables of Hb-response event definitions, origins, denominators, analyses and CIs is needed and remains subject to user review.	Original tables of Hb-response event definitions, origins, denominators, analyses and CIs.	Hb-rise details must link separately from the composite.
36	Unverified	Full text not readStored summary read	N36 · Evidence conditionAre absolute Hb change, group responder counts and durability verified?Required	Beyond the Hb ≥1 g/dL response HR, group responder counts/rates/denominators, mean Hb changes, unit-specific estimates, durability and detailed timepoints are absent from the summary. These are not filled from composite event counts. R01	Direct details are unverified within the current stored summary and unread external material. Original Hb responders, mean changes, timepoints, denominators, missingness and durability material is needed and remains subject to user review.	Original Hb responders, mean changes, timepoints, denominators, missingness and durability material.	Response magnitude and durability require direct detailed laboratory-outcome material.
37	Unverified	Full text not readStored summary read	N37 · Evidence conditionDo baseline Hb/iron status and achieved ferritin link to outcomes?Required	The target ferritin range is described, but group baseline Hb/iron status, achieved values, distributions and changes are unverified in the summary. Targets are not changed into actual measurements. R01	Direct details are unverified within the current stored summary and unread external material. Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure is needed and remains subject to user review.	Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure.	Material presenting targets separately from achieved values is needed.
38	Unverified	Full text not readStored summary read	N38 · Evidence conditionHow much is known about composite components and group contributions?Required	Overall composite events are retained, but additional-treatment-type events, contributions of consecutive-low-Hb, overlap, first events and recurrent-event counting are unverified in detail. Composite reduction is not extended to improvement in every component. R01	Direct details are unverified within the current stored summary and unread external material. Component events, denominators, overlap, time, effects and planned comparisons is needed and remains subject to user review.	Component events, denominators, overlap, time, effects and planned comparisons.	Material showing the composite alongside each component is needed.
39	Unverified	Full text not readStored summary read	N39 · Evidence conditionDo hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit?Supplementary; required for extension to patient benefit	Original material describes improved laboratory/treatment-decision surrogates. Direct symptom, quality-of-life or sustained post-follow-up benefits are absent from the summary and are not replaced by Hb response. R01	Direct details are unverified within the current stored summary and unread external material. Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons is needed and remains subject to user review.	Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons.	Patient-important outcomes must link the question and evidence using separate direct material.
40	Partly verified	Full text not readStored summary read	N40 · Evidence conditionDo current dialysis observations clinically validate Hb response?Required	Original wording reports 16 people overall (2.6%) starting dialysis over 56 weeks with no group difference. Group events, denominators, effects and CIs are unverified; insufficient power limits interpretation, so Hb response is not translated into reduced dialysis. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power is needed and remains subject to user review.	Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power.	Dialysis benefit requires direct comparisons designed to answer that clinical event adequately.
41	Partly verified	Full text not readStored summary read	N41 · Evidence conditionDo current mortality observations establish survival benefit?Required	Deaths are retained as high-target 7/154 (4.5%) versus oral 15/312 (4.8%). Detailed death definitions, between-group estimates, CIs and power are absent; Hb improvement does not establish increased survival. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Death counting, causes, analysis populations, follow-up, between-group estimation and precision material is needed and remains subject to user review.	Death counting, causes, analysis populations, follow-up, between-group estimation and precision material.	Survival benefit needs sufficient follow-up and comparison material directly addressing death.
42	Unverified	Full text not readStored summary read	N42 · Evidence conditionWhat direct cardiovascular-event reduction material is unverified?Required	The parent and clinical-event subclaim say reduced cardiovascular events cannot be concluded and the trial was not designed/powered to answer them. Current cardiovascular definitions, components, counts, denominators and CIs are absent. Absence of information is not changed to zero events or an established null effect. R01	Direct details are unverified within the current stored summary and unread external material. Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up is needed and remains subject to user review.	Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up.	Cardiovascular benefits require material powered directly for those outcomes.
43	Partly verified	Full text not readStored summary read	N43 · Evidence conditionWhat limits extension from hemoglobin-centred response to clinical events?Required	Subclaim C and the improved-surrogate-composite note are retained. Laboratory/additional-treatment improvement is not extended to separate dialysis, mortality or cardiovascular-protection claims. Positive Hb response remains alongside unverified patient-event benefit. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Direct surrogate-clinical-outcome relationships and separate outcome material is needed and remains subject to user review.	Direct surrogate-clinical-outcome relationships and separate outcome material.	Extension questions require added material directly measuring/testing patient events.
44	Unverified	Full text not readStored summary read	N44 · Evidence conditionWas the same strategy/outcome replicated in other independent research?Supplementary; required to claim independent replication	The current direct evidence entry is one FIND-CKD report. Independent replication, new material or separate clinical-event trials of the same strategy are unverified within the current original material. Parent R1/I0 history is not changed into new independent-count certification. R01	Direct details are unverified within the current stored summary and unread external material. Bibliographic, registration and population independence with direct same-strategy/outcome comparisons is needed and remains subject to user review.	Bibliographic, registration and population independence with direct same-strategy/outcome comparisons.	Added independent results first distinguish trial, report and population sharing.
45	Partly verified	Full text not readStored summary read	N45 · Evidence conditionWhat is preserved when formulation, population or duration changes, or material is corrected?Required (update boundaries)	Current scope is original high-ferritin-target intravenous iron versus oral iron over 56 weeks in nondialysis CKD anemia. Effects across other formulations, targets, populations or timepoints are not merged automatically; new stored summaries/corrections must be recorded as separate events. R01	Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete pre-change original text, new material versions and reasons for question/condition/observation changes is needed and remains subject to user review.	Complete pre-change original text, new material versions and reasons for question/condition/observation changes.	Added material separates condition-version changes from observation application and retains user-review requirements.

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45 itemsWhat the statuses mean

Assessment scope

Stored-material review date: Not recorded
Original evidence cut-off: 2026-08-26
Scope actually checked: Existing review summaries and stored records of methodological application. Full papers, supplements, registrations, plans and original data were not read.
What the dates mean: This is the date the stored materials were checked, not the date of a new search of the clinical literature.
Population: Hemoglobin response in iron-deficiency anemia with nondialysis chronic kidney disease
Ingredient, formulation and route: High-ferritin-target intravenous ferric carboxymaltose
Dose: The ferritin 400~600 µg/L target and oral iron 100 mg twice daily are retained only as historical research conditions. Actual intravenous doses, frequency and achieved values are unverified; no dose conversions or use guidance are created.
Comparator: Oral ferrous sulfate active control. Details of the other group in the three-arm design are unverified in the current summary.
Measured outcome: Initiation of other anemia management or consecutive Hb <10 g/dL during weeks 8~52; separate Hb ≥1 g/dL response
Duration: 56-week design; the primary composite Hb criterion concerns weeks 8~52. Exact analysis origins, follow-up and censoring for each clinical event are unverified.
Questions outside this scope: Extending surrogate outcomes to dialysis, survival or cardiovascular protection; Generalizing to all iron formulations, ferritin targets, dialysis states or long-term safety; Administration, treatment-target, dialysis or treatment-suitability recommendations; Adding the same report, trial, population, two sheets or events as independent replication

Evidence and sources

The links below lead to the sources. A link alone does not mean the original source was read or its latest publication status verified.

R01 · Macdougall IC, Bock AH, Carrera F, et al. FIND-CKD. Nephrol Dial Transplant. 2014;29(11):2075-2084. PMID: 24891437.

PubMed

Material type: 56-week multicentre randomized open-label three-arm active-control trial
Materials actually read: Summary read; external papers and registration unread
Findings recorded in the stored summary: 23.5% versus 31.8%; HR 0.65 (0.44~0.95), absolute difference -8.3%p, NNT 12
Record level: Original research-assessment wording in the stored summary
Study overlap and independent replication: The existing two-sheet structure separates Hb-centred and clinical-event outcomes from the same FIND-CKD PMID 24891437, registration identifier NCT00994318, report and population. It shares 626 randomized, 613 ITT, 519 completed and different outcomes/denominators. Existing citation 2560 concerns the same drug in another preoperative setting and is not added as a new trial/participant total for this direct report.

Public availability, access and reading status by material
Material	Public availability	Access status	Actually read	Notes
Stored summary	Stored summary	Stored summary read for production	Summary read	The complete parent stored summary was read for production; the original paper was not acquired/read.
Paper abstract	External material unread; needed	Access not attempted; not obtained	Not read	Only the stored PMID link is connected. Actual abstract content and original numerical locations were not verified.
Full paper	External material unread; needed	Access not attempted; not obtained	Not read	The URL is a bibliographic link; full-text acquisition/accessibility was not verified.
Clinical trial registration	External material unread; needed	Access not attempted; not obtained	Not read	Only the registration identifier is retained. Registration URL/content, initial/amended versions and prespecified plans are unverified.
Study protocol	External material unread; needed	Access not attempted; not obtained	Not read	Original plans for three-group strategies, clinical hypotheses, components, follow-up and additional-treatment rules have not been acquired.
Statistical analysis plan	External material unread; needed	Access not attempted; not obtained	Not read	Detailed hierarchy, time models, analysis populations, missingness, clinical-event power and multiplicity plans have not been acquired.
Original results and safety tables	External material unread; needed	Access not attempted; not obtained	Not read	Original tables are needed to verify Hb composite/response and dialysis, death, cardiovascular and infection event definitions, denominators, models, follow-up and detailed intervals.
Sponsorship and interest disclosures	External material unread; needed	Access not attempted; not obtained	Not read	Beyond summarized sponsorship/oral-iron supply, original author conflicts, data-access, analysis and publication roles have not been acquired.
Related verdict in a different setting	External material unread; needed	Access not attempted; not obtained	Not read	Historical D, 34-point link for the same drug in another preoperative setting. It is not added as a direct clinical report or independent replication here; the page was not read.

Report counts versus independent study counts

The existing two-sheet structure separates Hb-centred and clinical-event outcomes from the same FIND-CKD PMID 24891437, registration identifier NCT00994318, report and population. It shares 626 randomized, 613 ITT, 519 completed and different outcomes/denominators. Existing citation 2560 concerns the same drug in another preoperative setting and is not added as a new trial/participant total for this direct report.

Review criteria

Version 1.0 · Criteria record date 2026-10-06. These are Chamgap's own application conditions, informed by the referenced methods. They do not constitute official assessment-tool certification or a new efficacy score.

N01 · Which existing subclaim and question direction does this sheet preserve?

Required materials and conditions: Material retaining the selected subclaim-parent relationship, original question and verdict record.
Conditions for verification: Which existing subclaim and question direction does this sheet preserve? Distinguish Material retaining the selected subclaim-parent relationship, original question and verdict record in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Which existing subclaim and question direction does this sheet preserve? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N02 · How are subclaim grade/note and absent score, status and axes distinguished?

Required materials and conditions: Actual selected-subclaim fields and separately retained parent fields.
Conditions for verification: How are subclaim grade/note and absent score, status and axes distinguished? Distinguish Actual selected-subclaim fields and separately retained parent fields in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: How are subclaim grade/note and absent score, status and axes distinguished? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N03 · What historical context do parent C, 50 points, axes, safety and empty values represent?

Required materials and conditions: Complete parent verdict, axes, safety labels and actual change history.
Conditions for verification: What historical context do parent C, 50 points, axes, safety and empty values represent? Distinguish Complete parent verdict, axes, safety labels and actual change history in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Parent scores/axes are historical context and do not fill absent selected-subclaim values.
Why this condition is needed: What historical context do parent C, 50 points, axes, safety and empty values represent? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N04 · How are original Korean/English, reference dates and correction histories retained?

Required materials and conditions: Complete original text, language-specific explanations, reference dates and additional correction records.
Conditions for verification: How are original Korean/English, reference dates and correction histories retained? Distinguish Complete original text, language-specific explanations, reference dates and additional correction records in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Historical cross-check and research-assessment wording does not mean newly completed review.
Why this condition is needed: How are original Korean/English, reference dates and correction histories retained? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N05 · Which materials were actually read for this production and which external materials remain unread?

Required materials and conditions: Acquisition/reading levels and relevant result locations in original source material.
Conditions for verification: Which materials were actually read for this production and which external materials remain unread? Distinguish Acquisition/reading levels and relevant result locations in original source material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: URLs link sources without being upgraded to reading, link testing or content verification.
Why this condition is needed: Which materials were actually read for this production and which external materials remain unread? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N06 · What are the FIND-CKD report bibliography and registration identity?

Required materials and conditions: Paper bibliography, original full text, registration content and their actual links.
Conditions for verification: What are the FIND-CKD report bibliography and registration identity? Distinguish Paper bibliography, original full text, registration content and their actual links in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: A registration identifier does not verify registration content or certify a unique trial.
Why this condition is needed: What are the FIND-CKD report bibliography and registration identity? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N07 · How do two subclaim sheets share one trial, report and population?

Required materials and conditions: Original material distinguishing trial, report, population, group, outcome links and overlap.
Conditions for verification: How do two subclaim sheets share one trial, report and population? Distinguish Original material distinguishing trial, report, population, group, outcome links and overlap in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: New-unit increment remains 0 and the final independent count remains null.
Why this condition is needed: How do two subclaim sheets share one trial, report and population? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N08 · Which nondialysis chronic kidney disease anemia population was studied?

Required materials and conditions: Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria.
Conditions for verification: Which nondialysis chronic kidney disease anemia population was studied? Distinguish Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Eligibility thresholds or disease stages absent from the current summary are not invented.
Why this condition is needed: Which nondialysis chronic kidney disease anemia population was studied? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N09 · How much is verified about baseline risk and representativeness?

Required materials and conditions: Group baseline tables, recruitment pathways, exclusions, severity and comorbidities.
Conditions for verification: How much is verified about baseline risk and representativeness? Distinguish Group baseline tables, recruitment pathways, exclusions, severity and comorbidities in original material and retain unverified limits.
Requirement and applicability: Supplementary; required for general application
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: How much is verified about baseline risk and representativeness? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N10 · What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose?

Required materials and conditions: Intervention strategy, product identity, target-adjustment rules and group achieved values.
Conditions for verification: What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose? Distinguish Intervention strategy, product identity, target-adjustment rules and group achieved values in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Historical targets are not written as treatment, dose or suitability guidance.
Why this condition is needed: What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N11 · What is the original research exposure of the oral ferrous sulfate control?

Required materials and conditions: Oral formulation, research exposure, actual use, discontinuation and adherence material.
Conditions for verification: What is the original research exposure of the oral ferrous sulfate control? Distinguish Oral formulation, research exposure, actual use, discontinuation and adherence material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Only original exposure values are retained; no new totals, conversions or use recommendations are calculated.
Why this condition is needed: What is the original research exposure of the oral ferrous sulfate control? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N12 · How are the selected comparison and other-group information separated in the three-arm design?

Required materials and conditions: Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans.
Conditions for verification: How are the selected comparison and other-group information separated in the three-arm design? Distinguish Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Other-group targets, denominators or effects are not inferred or back-calculated from totals.
Why this condition is needed: How are the selected comparison and other-group information separated in the three-arm design? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N13 · How much is known about actual intravenous administration, achieved ferritin, adherence and changes?

Required materials and conditions: Actual group administration, achieved values, adherence, changes and discontinuation records.
Conditions for verification: How much is known about actual intravenous administration, achieved ferritin, adherence and changes? Distinguish Actual group administration, achieved values, adherence, changes and discontinuation records in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: No new administered doses, schedules or unit conversions are created.
Why this condition is needed: How much is known about actual intravenous administration, achieved ferritin, adherence and changes? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N14 · Are starting ESA, transfusions or other iron concurrent care or outcome components?

Required materials and conditions: Additional-management initiation criteria, group use/timing and outcome-counting rules.
Conditions for verification: Are starting ESA, transfusions or other iron concurrent care or outcome components? Distinguish Additional-management initiation criteria, group use/timing and outcome-counting rules in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Treatment switches are not presented as the same outcome as patient events.
Why this condition is needed: Are starting ESA, transfusions or other iron concurrent care or outcome components? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N15 · Are 56-week follow-up and the weeks 8~52 composite window the same period?

Required materials and conditions: Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up.
Conditions for verification: Are 56-week follow-up and the weeks 8~52 composite window the same period? Distinguish Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Are 56-week follow-up and the weeks 8~52 composite window the same period? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N16 · What are the randomized, ITT and completed denominators?

Required materials and conditions: Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons.
Conditions for verification: What are the randomized, ITT and completed denominators? Distinguish Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: No new differences, proportions or participant totals are created from current numbers.
Why this condition is needed: What are the randomized, ITT and completed denominators? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N17 · How are group-denominator differences for the primary composite, death and infection recorded?

Required materials and conditions: Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables.
Conditions for verification: How are group-denominator differences for the primary composite, death and infection recorded? Distinguish Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: One denominator is not used to recalculate other outcomes or certify common ITT.
Why this condition is needed: How are group-denominator differences for the primary composite, death and infection recorded? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N18 · What effects remain uncertain from noncompletion and missingness?

Required materials and conditions: Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material.
Conditions for verification: What effects remain uncertain from noncompletion and missingness? Distinguish Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Attrition effects, new bias grades or lost-person counts are not calculated.
Why this condition is needed: What effects remain uncertain from noncompletion and missingness? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N19 · What is the verification scope of central randomization?

Required materials and conditions: Detailed allocation methods, protocols and implementation material.
Conditions for verification: What is the verification scope of central randomization? Distinguish Detailed allocation methods, protocols and implementation material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Central-allocation wording alone does not certify all randomization procedures as appropriate.
Why this condition is needed: What is the verification scope of central randomization? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N20 · What distinctions does open-label design require for treatment decisions and laboratory measurement?

Required materials and conditions: Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations.
Conditions for verification: What distinctions does open-label design require for treatment decisions and laboratory measurement? Distinguish Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: The original three-defect, avoidability and common bias-category wording remains historical only.
Why this condition is needed: What distinctions does open-label design require for treatment decisions and laboratory measurement? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N21 · Was NCT00994318 registration content actually verified?

Required materials and conditions: Original registration text, versions, endpoints, analyses and changes.
Conditions for verification: Was NCT00994318 registration content actually verified? Distinguish Original registration text, versions, endpoints, analyses and changes in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: A registration number is not displayed as actual reading or trial certification.
Why this condition is needed: Was NCT00994318 registration content actually verified? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N22 · At what level are primary/secondary endpoint and analysis hierarchies known?

Required materials and conditions: Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables.
Conditions for verification: At what level are primary/secondary endpoint and analysis hierarchies known? Distinguish Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Parent primary-endpoint wording is not upgraded to direct external-plan verification.
Why this condition is needed: At what level are primary/secondary endpoint and analysis hierarchies known? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N23 · What original information describes Vifor Pharma sponsorship and oral-iron supply?

Required materials and conditions: Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles.
Conditions for verification: What original information describes Vifor Pharma sponsorship and oral-iron supply? Distinguish Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What original information describes Vifor Pharma sponsorship and oral-iron supply? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N24 · What are the detailed author conflicts, data-access and publication roles?

Required materials and conditions: COI, sponsorship contracts, analysis, data-access and publication-role disclosures.
Conditions for verification: What are the detailed author conflicts, data-access and publication roles? Distinguish COI, sponsorship contracts, analysis, data-access and publication-role disclosures in original material and retain unverified limits.
Requirement and applicability: Supplementary; required for independence claims
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What are the detailed author conflicts, data-access and publication roles? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N25 · What safety scope do stored infection observations cover?

Required materials and conditions: Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power.
Conditions for verification: What safety scope do stored infection observations cover? Distinguish Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: No differences, ratios, P values or CIs beyond original values are calculated.
Why this condition is needed: What safety scope do stored infection observations cover? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N26 · Are detailed safety collection, sparse events and attrition verified?

Required materials and conditions: Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up.
Conditions for verification: Are detailed safety collection, sparse events and attrition verified? Distinguish Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Are detailed safety collection, sparse events and attrition verified? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N27 · What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors?

Required materials and conditions: Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events.
Conditions for verification: What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors? Distinguish Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events in original material and retain unverified limits.
Requirement and applicability: Supplementary; required for long-term/safety extension
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N28 · Is preoperative verdict 2560 for the same drug direct evidence here?

Required materials and conditions: Direct material and application limits for different use settings, populations, timepoints and clinical outcomes.
Conditions for verification: Is preoperative verdict 2560 for the same drug direct evidence here? Distinguish Direct material and application limits for different use settings, populations, timepoints and clinical outcomes in original material and retain unverified limits.
Requirement and applicability: Supplementary; required for limits of extension to other settings
Application exceptions: Another verdict grade is not inherited by this subclaim.
Why this condition is needed: Is preoperative verdict 2560 for the same drug direct evidence here? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N29 · What is the exact primary composite for hemoglobin-centred response?

Required materials and conditions: Exact composite plans, components, event-counting and first-event rules.
Conditions for verification: What is the exact primary composite for hemoglobin-centred response? Distinguish Exact composite plans, components, event-counting and first-event rules in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What is the exact primary composite for hemoglobin-centred response? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N30 · What are the primary-composite group events, denominators, HR and CI?

Required materials and conditions: Original composite tables, analysis populations, time models, CIs and covariate handling.
Conditions for verification: What are the primary-composite group events, denominators, HR and CI? Distinguish Original composite tables, analysis populations, time models, CIs and covariate handling in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Current values are not copied to other clinical endpoints or groups.
Why this condition is needed: What are the primary-composite group events, denominators, HR and CI? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N31 · How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ?

Required materials and conditions: Event definitions, origins, models, denominators and interpretation targets for each HR.
Conditions for verification: How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ? Distinguish Event definitions, origins, models, denominators and interpretation targets for each HR in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: HRs are not converted into RRs, response rates or new relative percentage changes.
Why this condition is needed: How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N32 · What original scope do the absolute difference and NNT concern?

Required materials and conditions: Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT.
Conditions for verification: What original scope do the absolute difference and NNT concern? Distinguish Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: No new NNTs, CIs or illustrative patient counts are calculated.
Why this condition is needed: What original scope do the absolute difference and NNT concern? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N33 · What are the count, measurement window and test conditions for consecutive Hb <10 g/dL?

Required materials and conditions: Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness.
Conditions for verification: What are the count, measurement window and test conditions for consecutive Hb <10 g/dL? Distinguish Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Test schedules or consecutive values outside the original text are not invented.
Why this condition is needed: What are the count, measurement window and test conditions for consecutive Hb <10 g/dL? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N34 · How was the additional-treatment-initiation component measured and decided?

Required materials and conditions: Component-specific initiation criteria, adjudication, group events, denominators and effects.
Conditions for verification: How was the additional-treatment-initiation component measured and decided? Distinguish Component-specific initiation criteria, adjudication, group events, denominators and effects in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: How was the additional-treatment-initiation component measured and decided? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N35 · What are the reported Hb ≥1 g/dL rise-response values?

Required materials and conditions: Original tables of Hb-response event definitions, origins, denominators, analyses and CIs.
Conditions for verification: What are the reported Hb ≥1 g/dL rise-response values? Distinguish Original tables of Hb-response event definitions, origins, denominators, analyses and CIs in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What are the reported Hb ≥1 g/dL rise-response values? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N36 · Are absolute Hb change, group responder counts and durability verified?

Required materials and conditions: Original Hb responders, mean changes, timepoints, denominators, missingness and durability material.
Conditions for verification: Are absolute Hb change, group responder counts and durability verified? Distinguish Original Hb responders, mean changes, timepoints, denominators, missingness and durability material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Are absolute Hb change, group responder counts and durability verified? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N37 · Do baseline Hb/iron status and achieved ferritin link to outcomes?

Required materials and conditions: Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure.
Conditions for verification: Do baseline Hb/iron status and achieved ferritin link to outcomes? Distinguish Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Do baseline Hb/iron status and achieved ferritin link to outcomes? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N38 · How much is known about composite components and group contributions?

Required materials and conditions: Component events, denominators, overlap, time, effects and planned comparisons.
Conditions for verification: How much is known about composite components and group contributions? Distinguish Component events, denominators, overlap, time, effects and planned comparisons in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: How much is known about composite components and group contributions? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N39 · Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit?

Required materials and conditions: Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons.
Conditions for verification: Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit? Distinguish Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons in original material and retain unverified limits.
Requirement and applicability: Supplementary; required for extension to patient benefit
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N40 · Do current dialysis observations clinically validate Hb response?

Required materials and conditions: Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power.
Conditions for verification: Do current dialysis observations clinically validate Hb response? Distinguish Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: The overall 16 people are not copied as events in each of two groups.
Why this condition is needed: Do current dialysis observations clinically validate Hb response? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N41 · Do current mortality observations establish survival benefit?

Required materials and conditions: Death counting, causes, analysis populations, follow-up, between-group estimation and precision material.
Conditions for verification: Do current mortality observations establish survival benefit? Distinguish Death counting, causes, analysis populations, follow-up, between-group estimation and precision material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: No new mortality differences, risk ratios, P values or CIs are calculated.
Why this condition is needed: Do current mortality observations establish survival benefit? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N42 · What direct cardiovascular-event reduction material is unverified?

Required materials and conditions: Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up.
Conditions for verification: What direct cardiovascular-event reduction material is unverified? Distinguish Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What direct cardiovascular-event reduction material is unverified? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N43 · What limits extension from hemoglobin-centred response to clinical events?

Required materials and conditions: Direct surrogate-clinical-outcome relationships and separate outcome material.
Conditions for verification: What limits extension from hemoglobin-centred response to clinical events? Distinguish Direct surrogate-clinical-outcome relationships and separate outcome material in original material and retain unverified limits.
Requirement and applicability: Required
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: What limits extension from hemoglobin-centred response to clinical events? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N44 · Was the same strategy/outcome replicated in other independent research?

Required materials and conditions: Bibliographic, registration and population independence with direct same-strategy/outcome comparisons.
Conditions for verification: Was the same strategy/outcome replicated in other independent research? Distinguish Bibliographic, registration and population independence with direct same-strategy/outcome comparisons in original material and retain unverified limits.
Requirement and applicability: Supplementary; required to claim independent replication
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Why this condition is needed: Was the same strategy/outcome replicated in other independent research? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

N45 · What is preserved when formulation, population or duration changes, or material is corrected?

Required materials and conditions: Complete pre-change original text, new material versions and reasons for question/condition/observation changes.
Conditions for verification: What is preserved when formulation, population or duration changes, or material is corrected? Distinguish Complete pre-change original text, new material versions and reasons for question/condition/observation changes in original material and retain unverified limits.
Requirement and applicability: Required (update boundaries)
Application exceptions: No new searches, calculations, grades or treatment recommendations are run in this production.
Why this condition is needed: What is preserved when formulation, population or duration changes, or material is corrected? This is needed to distinguish the direct scope of this question from other outcomes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Referenced methods and the sections actually reviewed

M03 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13

Referenced principle: Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M04 · Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03

Official methodology · §4.5, §4.6.1–4.6.3, MECIR C42

Referenced principle: Distinguish studies from reports and link them; do not omit a study solely because results are unreported.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M08 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §8.1–8.2.3, Table 8.2.a

Referenced principle: Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M15 · Cochrane Handbook 6.5 (2024), chapter updated 2023-08

Official methodology · §15.2.4, §15.3.1–15.3.3

Referenced principle: Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

M19 · Cochrane Handbook 6.5 (2024), chapter updated 2019-10

Official methodology · §19.1.2, §19.2.1–19.2.4

Referenced principle: Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.
Extent of review: Methodological principles stated in existing pilot materials and condition templates were referenced. The methodological text was not reviewed again in this work.

What the statuses mean

Met: The original content has been reviewed as meeting the conditions. This status is not used in this preparation.
Partly verified: Some information in the stored summary was linked during preparation; clinical verification or review is not complete.
Unverified: Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.
Review incomplete: Awaiting user review, or actual review remains incomplete.
Not reported: Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.
Inaccessible: Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.
Insufficient evidence for the conditions: Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.
Not applicable: Used when the reason it does not apply to the original question is stated.
Conflicting data: Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment.

Change history

2026-10-10 · Public page/material version 1.0

Public reader pages and material were prepared from the existing 45 items. No new clinical searches, verification-state changes or scoring were performed.

The stored-material review date (Not recorded) and original evidence cut-off (2026-08-26) were retained unchanged.

Researcher downloads

These materials provide the same evidence, scope and verification status as this page.

View all item details

N01 · Which existing subclaim and question direction does this sheet preserve?

Current findings: The selected stored summary concerns hemoglobin-centred response; the selected question and existing verdict record are distinguished. Parent hemoglobin-verdict and other-subclaim context is retained. No new question, split or verdict is created.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Material retaining the selected subclaim-parent relationship, original question and verdict record is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Material retaining the selected subclaim-parent relationship, original question and verdict record.
Required materials and conditions: Material retaining the selected subclaim-parent relationship, original question and verdict record.
Materials to obtain first: Material retaining the selected subclaim-parent relationship, original question and verdict record.
Further research: When additional material becomes available, the existing question scope is recorded separately from other questions.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Which existing subclaim and question direction does this sheet preserve? Distinguish Material retaining the selected subclaim-parent relationship, original question and verdict record in original material and retain unverified limits.
Why this condition is needed: Which existing subclaim and question direction does this sheet preserve? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N02 · How are subclaim grade/note and absent score, status and axes distinguished?

Current findings: The selected subclaim grade is C and its note says the surrogate composite improved. Subclaim score, status and axes are absent from the stored summary, recorded as null and field absence. Parent C, 50 points and axes are not substituted for subclaim values.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Actual selected-subclaim fields and separately retained parent fields is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Actual selected-subclaim fields and separately retained parent fields.
Required materials and conditions: Actual selected-subclaim fields and separately retained parent fields.
Materials to obtain first: Actual selected-subclaim fields and separately retained parent fields.
Further research: If the original subclaim is corrected, the complete pre-change text and change event are preserved.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How are subclaim grade/note and absent score, status and axes distinguished? Distinguish Actual selected-subclaim fields and separately retained parent fields in original material and retain unverified limits.
Why this condition is needed: How are subclaim grade/note and absent score, status and axes distinguished? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N03 · What historical context do parent C, 50 points, axes, safety and empty values represent?

Current findings: Parent C, 50 points and B/S/R1/I0/E+/B2 are preserved. Precision is unrecorded; coprimary splitting, large hard-endpoint RCT and no-human-study flags are false; grade-override reasons are empty in both languages. Parent safety is caution. These values are not inherited as selected-subclaim scores or newly satisfied conditions.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete parent verdict, axes, safety labels and actual change history is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Complete parent verdict, axes, safety labels and actual change history.
Required materials and conditions: Complete parent verdict, axes, safety labels and actual change history.
Materials to obtain first: Complete parent verdict, axes, safety labels and actual change history.
Further research: Even if a new verdict is requested, original grades and production status remain separately preserved.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What historical context do parent C, 50 points, axes, safety and empty values represent? Distinguish Complete parent verdict, axes, safety labels and actual change history in original material and retain unverified limits.
Why this condition is needed: What historical context do parent C, 50 points, axes, safety and empty values represent? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Parent scores/axes are historical context and do not fill absent selected-subclaim values.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N04 · How are original Korean/English, reference dates and correction histories retained?

Current findings: Parent and subclaim explanations in Korean/English are linked as originally written. The original reference date is 2026-08-26; corrections are an empty array and deliberation an empty value. Detailed Korean rates and concise English wording do not overwrite each other.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete original text, language-specific explanations, reference dates and additional correction records is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Complete original text, language-specific explanations, reference dates and additional correction records.
Required materials and conditions: Complete original text, language-specific explanations, reference dates and additional correction records.
Materials to obtain first: Complete original text, language-specific explanations, reference dates and additional correction records.
Further research: Added language-specific text or corrections preserve the complete existing version and link as a new event.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How are original Korean/English, reference dates and correction histories retained? Distinguish Complete original text, language-specific explanations, reference dates and additional correction records in original material and retain unverified limits.
Why this condition is needed: How are original Korean/English, reference dates and correction histories retained? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Historical cross-check and research-assessment wording does not mean newly completed review.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N05 · Which materials were actually read for this production and which external materials remain unread?

Current findings: The actual production input is the complete stored summary. Abstracts, full texts, registration, protocols, SAPs and original result tables were not accessed. Research-assessment wording in the summary does not mean current external reading.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Acquisition/reading levels and relevant result locations in original source material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Acquisition/reading levels and relevant result locations in original source material.
Required materials and conditions: Acquisition/reading levels and relevant result locations in original source material.
Materials to obtain first: Acquisition/reading levels and relevant result locations in original source material.
Further research: Separate additional reading must record its scope and time as a new event.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Which materials were actually read for this production and which external materials remain unread? Distinguish Acquisition/reading levels and relevant result locations in original source material in original material and retain unverified limits.
Why this condition is needed: Which materials were actually read for this production and which external materials remain unread? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: URLs link sources without being upgraded to reading, link testing or content verification.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N06 · What are the FIND-CKD report bibliography and registration identity?

Current findings: The stored direct report is Macdougall IC et al., 2014 FIND-CKD, linked to PMID 24891437 and NCT00994318. DOI, PMCID and external registration content are unverified.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Paper bibliography, original full text, registration content and their actual links is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Paper bibliography, original full text, registration content and their actual links.
Required materials and conditions: Paper bibliography, original full text, registration content and their actual links.
Materials to obtain first: Paper bibliography, original full text, registration content and their actual links.
Further research: Added report identities must be distinguished as the same trial or separate trials using original material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the FIND-CKD report bibliography and registration identity? Distinguish Paper bibliography, original full text, registration content and their actual links in original material and retain unverified limits.
Why this condition is needed: What are the FIND-CKD report bibliography and registration identity? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: A registration identifier does not verify registration content or certify a unique trial.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N07 · How do two subclaim sheets share one trial, report and population?

Current findings: The hemoglobin-response and clinical-event sheets share the same FIND-CKD report/population. Hemoglobin, dialysis, death, infection or two sheets are not added as independent trials/participants. One stored bibliographic entry does not certify a unique trial count.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original material distinguishing trial, report, population, group, outcome links and overlap is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original material distinguishing trial, report, population, group, outcome links and overlap.
Required materials and conditions: Original material distinguishing trial, report, population, group, outcome links and overlap.
Materials to obtain first: Original material distinguishing trial, report, population, group, outcome links and overlap.
Further research: New follow-up/related reports link to the existing family; independent replication requires separate material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How do two subclaim sheets share one trial, report and population? Distinguish Original material distinguishing trial, report, population, group, outcome links and overlap in original material and retain unverified limits.
Why this condition is needed: How do two subclaim sheets share one trial, report and population? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: New-unit increment remains 0 and the final independent count remains null.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N08 · Which nondialysis chronic kidney disease anemia population was studied?

Current findings: The parent question concerns iron-deficiency anemia in nondialysis chronic kidney disease. Results are not automatically transferred to dialysis patients, other anemia causes or preoperative preparation.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria.
Required materials and conditions: Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria.
Materials to obtain first: Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria.
Further research: Population differences require direct comparison material for the relevant populations.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Which nondialysis chronic kidney disease anemia population was studied? Distinguish Nondialysis iron-deficiency anemia eligibility, recruitment and exclusion criteria in original material and retain unverified limits.
Why this condition is needed: Which nondialysis chronic kidney disease anemia population was studied? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Eligibility thresholds or disease stages absent from the current summary are not invented.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N09 · How much is verified about baseline risk and representativeness?

Current findings: Detailed age, kidney-disease stage, baseline Hb/iron status, comorbidities and group distributions of clinical-event risk are absent from the current summary. A population name does not establish identical responses in all nondialysis patients.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Group baseline tables, recruitment pathways, exclusions, severity and comorbidities is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Group baseline tables, recruitment pathways, exclusions, severity and comorbidities.
Required materials and conditions: Group baseline tables, recruitment pathways, exclusions, severity and comorbidities.
Materials to obtain first: Group baseline tables, recruitment pathways, exclusions, severity and comorbidities.
Further research: Application to different risk populations must be distinguished using direct studies with follow-up.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How much is verified about baseline risk and representativeness? Distinguish Group baseline tables, recruitment pathways, exclusions, severity and comorbidities in original material and retain unverified limits.
Why this condition is needed: How much is verified about baseline risk and representativeness? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N10 · What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose?

Current findings: The historical high-group ferritin target is 400~600 µg/L. It is a trial strategy condition, not an achieved value or a recommended target. It is not extended to other iron formulations/targets.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Intervention strategy, product identity, target-adjustment rules and group achieved values is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Intervention strategy, product identity, target-adjustment rules and group achieved values.
Required materials and conditions: Intervention strategy, product identity, target-adjustment rules and group achieved values.
Materials to obtain first: Intervention strategy, product identity, target-adjustment rules and group achieved values.
Further research: Differences by formulation or target require direct strategy-comparison material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose? Distinguish Intervention strategy, product identity, target-adjustment rules and group achieved values in original material and retain unverified limits.
Why this condition is needed: What are the research conditions for high-ferritin-target intravenous ferric carboxymaltose? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Historical targets are not written as treatment, dose or suitability guidance.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N11 · What is the original research exposure of the oral ferrous sulfate control?

Current findings: The original oral control provided 100 mg iron as ferrous sulfate twice daily. This compares an active control with the intravenous-iron strategy; no dosing guidance or dose conversion is created.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Oral formulation, research exposure, actual use, discontinuation and adherence material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Oral formulation, research exposure, actual use, discontinuation and adherence material.
Required materials and conditions: Oral formulation, research exposure, actual use, discontinuation and adherence material.
Materials to obtain first: Oral formulation, research exposure, actual use, discontinuation and adherence material.
Further research: Material with different control conditions is linked separately with those differences specified.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What is the original research exposure of the oral ferrous sulfate control? Distinguish Oral formulation, research exposure, actual use, discontinuation and adherence material in original material and retain unverified limits.
Why this condition is needed: What is the original research exposure of the oral ferrous sulfate control? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Only original exposure values are retained; no new totals, conversions or use recommendations are calculated.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N12 · How are the selected comparison and other-group information separated in the three-arm design?

Current findings: FIND-CKD is a 56-week multicentre randomized open-label three-arm active-control trial. The selected stored comparison is high-ferritin-target intravenous iron versus oral iron; specific targets, group values and exposure of the other intravenous-iron group are absent from the summary.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans.
Required materials and conditions: Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans.
Materials to obtain first: Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans.
Further research: Added other-group results retain separate attribution from the current comparison.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How are the selected comparison and other-group information separated in the three-arm design? Distinguish Actual three-group allocation, exposure, analysis/control tables and selected-comparison plans in original material and retain unverified limits.
Why this condition is needed: How are the selected comparison and other-group information separated in the three-arm design? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Other-group targets, denominators or effects are not inferred or back-calculated from totals.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N13 · How much is known about actual intravenous administration, achieved ferritin, adherence and changes?

Current findings: Intravenous formulation and target strategy are described, but actual doses/frequency, group cumulative exposure, achieved ferritin, oral adherence and changes are unverified in the current summary.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Actual group administration, achieved values, adherence, changes and discontinuation records is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Actual group administration, achieved values, adherence, changes and discontinuation records.
Required materials and conditions: Actual group administration, achieved values, adherence, changes and discontinuation records.
Materials to obtain first: Actual group administration, achieved values, adherence, changes and discontinuation records.
Further research: Exposure differences require material linking actual strategy implementation with outcomes.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How much is known about actual intravenous administration, achieved ferritin, adherence and changes? Distinguish Actual group administration, achieved values, adherence, changes and discontinuation records in original material and retain unverified limits.
Why this condition is needed: How much is known about actual intravenous administration, achieved ferritin, adherence and changes? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No new administered doses, schedules or unit conversions are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N14 · Are starting ESA, transfusions or other iron concurrent care or outcome components?

Current findings: Clinician decisions to start ESA, transfusions or other iron entered the primary composite. Actual treatment frequency, criteria and group courses are absent from the summary, requiring concurrent-management and composite-component roles to be distinguished.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Additional-management initiation criteria, group use/timing and outcome-counting rules is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Additional-management initiation criteria, group use/timing and outcome-counting rules.
Required materials and conditions: Additional-management initiation criteria, group use/timing and outcome-counting rules.
Materials to obtain first: Additional-management initiation criteria, group use/timing and outcome-counting rules.
Further research: Interpreting additional management requires plans alongside actual courses.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Are starting ESA, transfusions or other iron concurrent care or outcome components? Distinguish Additional-management initiation criteria, group use/timing and outcome-counting rules in original material and retain unverified limits.
Why this condition is needed: Are starting ESA, transfusions or other iron concurrent care or outcome components? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Treatment switches are not presented as the same outcome as patient events.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N15 · Are 56-week follow-up and the weeks 8~52 composite window the same period?

Current findings: The overall design is 56 weeks; the primary composite Hb window is weeks 8~52. Overall follow-up and outcome-specific counting windows are not merged.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up.
Required materials and conditions: Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up.
Materials to obtain first: Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up.
Further research: Added timepoint-specific material links each outcome to its relevant period separately.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Are 56-week follow-up and the weeks 8~52 composite window the same period? Distinguish Original plans/tables for outcome-specific origins, measurement intervals, analysis windows, end and follow-up in original material and retain unverified limits.
Why this condition is needed: Are 56-week follow-up and the weeks 8~52 composite window the same period? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N16 · What are the randomized, ITT and completed denominators?

Current findings: Stored counts of 626 randomized, 613 ITT and 519 completed are distinguished. The stored summary says 519/626 (82.9%) completed and 17.1% did not complete. These denominators are not applied uniformly to all outcomes and exclusions are not newly calculated.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons.
Required materials and conditions: Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons.
Materials to obtain first: Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons.
Further research: Added actual analysis inclusion/missingness rules supplement outcome-specific links.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the randomized, ITT and completed denominators? Distinguish Overall/group flowcharts, analysis-population definitions and exclusion/follow-up-discontinuation reasons in original material and retain unverified limits.
Why this condition is needed: What are the randomized, ITT and completed denominators? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No new differences, proportions or participant totals are created from current numbers.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N17 · How are group-denominator differences for the primary composite, death and infection recorded?

Current findings: Primary-composite denominators are high-target 153 and oral 308; original death/infection denominators are 154 and 312. These differ; exact analysis-population definitions and exclusion reasons remain externally unread.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables.
Required materials and conditions: Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables.
Materials to obtain first: Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables.
Further research: Original explanations of outcome-specific denominators link only to the corresponding rows.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How are group-denominator differences for the primary composite, death and infection recorded? Distinguish Outcome-specific group, analysis-population, follow-up, missingness and event-counting tables in original material and retain unverified limits.
Why this condition is needed: How are group-denominator differences for the primary composite, death and infection recorded? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: One denominator is not used to recalculate other outcomes or certify common ITT.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N18 · What effects remain uncertain from noncompletion and missingness?

Current findings: The stored assessment retains historical limitations of 17.1% noncompletion and substantial attrition. Group reasons, outcome-specific missingness, imputation and sensitivity analyses cannot be verified from the summary alone. The historical ≥15% category is not run as a new automatic scoring rule.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material.
Required materials and conditions: Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material.
Materials to obtain first: Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material.
Further research: Changes under missingness assumptions must be distinguished using original analyses/additional material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What effects remain uncertain from noncompletion and missingness? Distinguish Group missingness reasons, follow-up retrieval, analysis handling and sensitivity material in original material and retain unverified limits.
Why this condition is needed: What effects remain uncertain from noncompletion and missingness? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Attrition effects, new bias grades or lost-person counts are not calculated.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N19 · What is the verification scope of central randomization?

Current findings: The stored account says central interactive voice-response randomization was used. Actual sequence generation, concealment, stratification and implementation details remain externally unread.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Detailed allocation methods, protocols and implementation material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Detailed allocation methods, protocols and implementation material.
Required materials and conditions: Detailed allocation methods, protocols and implementation material.
Materials to obtain first: Detailed allocation methods, protocols and implementation material.
Further research: Added allocation procedures must retain known levels separately from unverified details.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What is the verification scope of central randomization? Distinguish Detailed allocation methods, protocols and implementation material in original material and retain unverified limits.
Why this condition is needed: What is the verification scope of central randomization? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Central-allocation wording alone does not certify all randomization procedures as appropriate.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N20 · What distinctions does open-label design require for treatment decisions and laboratory measurement?

Current findings: The original limitation of open-label design and clinician additional-treatment decisions in the primary composite is retained. Laboratory measurement, assessor masking and consistent decision criteria are unverified in detail. No new claim that all Hb tests are inherently subjective is made.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations.
Required materials and conditions: Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations.
Materials to obtain first: Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations.
Further research: Material separating component measurement from decision procedures is needed.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What distinctions does open-label design require for treatment decisions and laboratory measurement? Distinguish Laboratory/assessor masking, treatment-decision criteria, adjudication and control-group operations in original material and retain unverified limits.
Why this condition is needed: What distinctions does open-label design require for treatment decisions and laboratory measurement? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: The original three-defect, avoidability and common bias-category wording remains historical only.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N21 · Was NCT00994318 registration content actually verified?

Current findings: NCT00994318 is retained as the existing registration identifier. Registration was not opened here; initial registration date, prespecified endpoints, amendments, posted results and paper comparisons remain unverified.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Original registration text, versions, endpoints, analyses and changes is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original registration text, versions, endpoints, analyses and changes.
Required materials and conditions: Original registration text, versions, endpoints, analyses and changes.
Materials to obtain first: Original registration text, versions, endpoints, analyses and changes.
Further research: Separately acquired registration material must retain its version and relationship to reports.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Was NCT00994318 registration content actually verified? Distinguish Original registration text, versions, endpoints, analyses and changes in original material and retain unverified limits.
Why this condition is needed: Was NCT00994318 registration content actually verified? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: A registration number is not displayed as actual reading or trial certification.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N22 · At what level are primary/secondary endpoint and analysis hierarchies known?

Current findings: The parent explanation distinguishes the other-anemia-management/consecutive-low-Hb composite as the exact primary endpoint. Prespecified plans, multiplicity and analysis hierarchy for Hb rise and clinical/safety events remain unread in registration, protocols and SAPs.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables.
Required materials and conditions: Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables.
Materials to obtain first: Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables.
Further research: Added plans link prespecified and post hoc distinctions to each outcome.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: At what level are primary/secondary endpoint and analysis hierarchies known? Distinguish Prespecified plans, hierarchy, hypotheses, multiple comparisons, analysis versions and original tables in original material and retain unverified limits.
Why this condition is needed: At what level are primary/secondary endpoint and analysis hierarchies known? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Parent primary-endpoint wording is not upgraded to direct external-plan verification.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N23 · What original information describes Vifor Pharma sponsorship and oral-iron supply?

Current findings: Stored material specifies Vifor Pharma sponsorship and oral-iron supply. Parent manufacturer-single-trial assessment remains historical. Sponsorship alone does not trigger a new verdict invalidating results.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles.
Required materials and conditions: Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles.
Materials to obtain first: Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles.
Further research: Added sponsorship, data-access or analysis-involvement information is recorded separately from interpretation limits.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What original information describes Vifor Pharma sponsorship and oral-iron supply? Distinguish Original disclosures of sponsorship, product supply, design, data management, analysis and publication roles in original material and retain unverified limits.
Why this condition is needed: What original information describes Vifor Pharma sponsorship and oral-iron supply? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N24 · What are the detailed author conflicts, data-access and publication roles?

Current findings: Beyond summarized sponsorship/product supply, detailed author conflicts, contracts, data-access/analysis independence and publication decisions are unverified. Unverified information is not changed to absence of conflicts.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. COI, sponsorship contracts, analysis, data-access and publication-role disclosures is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; COI, sponsorship contracts, analysis, data-access and publication-role disclosures.
Required materials and conditions: COI, sponsorship contracts, analysis, data-access and publication-role disclosures.
Materials to obtain first: COI, sponsorship contracts, analysis, data-access and publication-role disclosures.
Further research: Added independent reports first distinguish actual parties, data sharing and analysis relationships.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the detailed author conflicts, data-access and publication roles? Distinguish COI, sponsorship contracts, analysis, data-access and publication-role disclosures in original material and retain unverified limits.
Why this condition is needed: What are the detailed author conflicts, data-access and publication roles? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N25 · What safety scope do stored infection observations cover?

Current findings: Infections were high-target 51/154 (33.1%) versus oral 95/312 (30.4%). Historical wording describing similar infection events is retained alongside inadequate safety power. No absence of increased risk is established.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power.
Required materials and conditions: Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power.
Materials to obtain first: Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power.
Further research: Clinically important infection harms require appropriate event collection, follow-up and comparisons.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What safety scope do stored infection observations cover? Distinguish Infection definitions, collection periods, group analysis populations, severity, effects/CIs and planned power in original material and retain unverified limits.
Why this condition is needed: What safety scope do stored infection observations cover? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No differences, ratios, P values or CIs beyond original values are calculated.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N26 · Are detailed safety collection, sparse events and attrition verified?

Current findings: Some infection, death and dialysis values exist, but detailed collection methods, recurrent-event handling, assessors, period-specific missingness, severity and original safety tables are unverified. No attempted access is not changed to nonreporting or inaccessibility.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up.
Required materials and conditions: Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up.
Materials to obtain first: Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up.
Further research: Safety signals require material with definitions, ascertainment, denominators and follow-up.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Are detailed safety collection, sparse events and attrition verified? Distinguish Original safety tables, collection rules, missingness, discontinuation reasons and event-specific denominators/follow-up in original material and retain unverified limits.
Why this condition is needed: Are detailed safety collection, sparse events and attrition verified? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N27 · What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors?

Current findings: Results in the selected 56-week population are not extended to long-term/rare harms or safety in other kidney-disease states. Detailed links among baseline disease, concurrent care, treatment selection and events are absent, so sole causation or harmlessness cannot be established.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events.
Required materials and conditions: Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events.
Materials to obtain first: Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events.
Further research: Long-term/rare clinical harms need separate material with sufficient follow-up and appropriate comparisons.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors? Distinguish Material linking long-term follow-up, vulnerable populations, baseline risk, concurrent care, discontinuation and events in original material and retain unverified limits.
Why this condition is needed: What harm-evidence gaps concern long-term outcomes, vulnerable populations and alternative factors? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N28 · Is preoperative verdict 2560 for the same drug direct evidence here?

Current findings: Existing citation 2560 concerns preoperative intravenous ferric carboxymaltose and transfusion/death in a different setting, linked as historical D, 34 points. It is not added as direct nondialysis chronic-anemia evidence or a new independent trial entry. That page remains unread.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Direct material and application limits for different use settings, populations, timepoints and clinical outcomes is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Direct material and application limits for different use settings, populations, timepoints and clinical outcomes.
Required materials and conditions: Direct material and application limits for different use settings, populations, timepoints and clinical outcomes.
Materials to obtain first: Direct material and application limits for different use settings, populations, timepoints and clinical outcomes.
Further research: Material from other settings is not merged by drug name alone; question/population differences remain recorded.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Is preoperative verdict 2560 for the same drug direct evidence here? Distinguish Direct material and application limits for different use settings, populations, timepoints and clinical outcomes in original material and retain unverified limits.
Why this condition is needed: Is preoperative verdict 2560 for the same drug direct evidence here? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Another verdict grade is not inherited by this subclaim.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources

N29 · What is the exact primary composite for hemoglobin-centred response?

Current findings: The stored primary endpoint is initiation of other anemia management or consecutive Hb <10 g/dL during weeks 8~52, rather than simply Hb-rise response. The subclaim title and actual composite definition remain side by side.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Exact composite plans, components, event-counting and first-event rules is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Exact composite plans, components, event-counting and first-event rules.
Required materials and conditions: Exact composite plans, components, event-counting and first-event rules.
Materials to obtain first: Exact composite plans, components, event-counting and first-event rules.
Further research: Original material separating composite definitions from component-specific effects is needed.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What is the exact primary composite for hemoglobin-centred response? Distinguish Exact composite plans, components, event-counting and first-event rules in original material and retain unverified limits.
Why this condition is needed: What is the exact primary composite for hemoglobin-centred response? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N30 · What are the primary-composite group events, denominators, HR and CI?

Current findings: The primary composite is stored as high-target 36/153 (23.5%) versus oral 98/308 (31.8%), HR 0.65 (95% CI 0.44~0.95). These are between-group composite values, not dialysis, mortality or cardiovascular HRs.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original composite tables, analysis populations, time models, CIs and covariate handling is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original composite tables, analysis populations, time models, CIs and covariate handling.
Required materials and conditions: Original composite tables, analysis populations, time models, CIs and covariate handling.
Materials to obtain first: Original composite tables, analysis populations, time models, CIs and covariate handling.
Further research: Material with different estimands or analysis populations is shown separately.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the primary-composite group events, denominators, HR and CI? Distinguish Original composite tables, analysis populations, time models, CIs and covariate handling in original material and retain unverified limits.
Why this condition is needed: What are the primary-composite group events, denominators, HR and CI? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Current values are not copied to other clinical endpoints or groups.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N31 · How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ?

Current findings: The original composite concerns reduced additional-treatment/consecutive-low-Hb events, with HR 0.65. Hb ≥1 g/dL rise is a separate outcome with HR 2.04. HRs for different event definitions/directions are not changed into the same response rate or clinical efficacy.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Event definitions, origins, models, denominators and interpretation targets for each HR is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Event definitions, origins, models, denominators and interpretation targets for each HR.
Required materials and conditions: Event definitions, origins, models, denominators and interpretation targets for each HR.
Materials to obtain first: Event definitions, origins, models, denominators and interpretation targets for each HR.
Further research: Added analysis definitions link each outcome to its estimand separately.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ? Distinguish Event definitions, origins, models, denominators and interpretation targets for each HR in original material and retain unverified limits.
Why this condition is needed: How do the directions of composite HR 0.65 and Hb-rise HR 2.04 differ? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: HRs are not converted into RRs, response rates or new relative percentage changes.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N32 · What original scope do the absolute difference and NNT concern?

Current findings: The stored composite absolute difference is -8.3%p and NNT is 12. These remain within the original composite/comparison/period context without new calculations; they are not displayed as survival/dialysis-benefit counts.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT.
Required materials and conditions: Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT.
Materials to obtain first: Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT.
Further research: Added original explanations supplement the application scope of existing values.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What original scope do the absolute difference and NNT concern? Distinguish Original estimation timepoints, populations, analyses and intervals for absolute effects/NNT in original material and retain unverified limits.
Why this condition is needed: What original scope do the absolute difference and NNT concern? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No new NNTs, CIs or illustrative patient counts are calculated.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

Related sources R01

N33 · What are the count, measurement window and test conditions for consecutive Hb <10 g/dL?

Current findings: Korean consecutive Hb <10 g/dL wording and English two consecutive Hb values below 10 g/dL are preserved. The window is weeks 8~52 and < is not changed to another inequality. Actual test intervals, specimens, equipment and confirmation rules are unverified.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness.
Required materials and conditions: Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness.
Materials to obtain first: Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness.
Further research: Added measurement plans link the actual rules for two consecutive values.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the count, measurement window and test conditions for consecutive Hb <10 g/dL? Distinguish Consecutive-measurement plans, intervals, laboratory standardization and event handling under missingness in original material and retain unverified limits.
Why this condition is needed: What are the count, measurement window and test conditions for consecutive Hb <10 g/dL? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Test schedules or consecutive values outside the original text are not invented.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N34 · How was the additional-treatment-initiation component measured and decided?

Current findings: The original limitation is that clinician decisions to start ESA, transfusions or other iron entered the open-label composite. Group initiation criteria, frequencies, first-event timing and component effects are unverified.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Component-specific initiation criteria, adjudication, group events, denominators and effects is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Component-specific initiation criteria, adjudication, group events, denominators and effects.
Required materials and conditions: Component-specific initiation criteria, adjudication, group events, denominators and effects.
Materials to obtain first: Component-specific initiation criteria, adjudication, group events, denominators and effects.
Further research: Composite contents require material presenting treatment decisions and repeated-Hb criteria separately.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How was the additional-treatment-initiation component measured and decided? Distinguish Component-specific initiation criteria, adjudication, group events, denominators and effects in original material and retain unverified limits.
Why this condition is needed: How was the additional-treatment-initiation component measured and decided? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N35 · What are the reported Hb ≥1 g/dL rise-response values?

Current findings: Hb ≥1 g/dL response HR is 2.04 (95% CI 1.52~2.72). It is retained as the original laboratory-response outcome; this HR is not direct dialysis/survival benefit.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Original tables of Hb-response event definitions, origins, denominators, analyses and CIs is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original tables of Hb-response event definitions, origins, denominators, analyses and CIs.
Required materials and conditions: Original tables of Hb-response event definitions, origins, denominators, analyses and CIs.
Materials to obtain first: Original tables of Hb-response event definitions, origins, denominators, analyses and CIs.
Further research: Hb-rise details must link separately from the composite.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What are the reported Hb ≥1 g/dL rise-response values? Distinguish Original tables of Hb-response event definitions, origins, denominators, analyses and CIs in original material and retain unverified limits.
Why this condition is needed: What are the reported Hb ≥1 g/dL rise-response values? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N36 · Are absolute Hb change, group responder counts and durability verified?

Current findings: Beyond the Hb ≥1 g/dL response HR, group responder counts/rates/denominators, mean Hb changes, unit-specific estimates, durability and detailed timepoints are absent from the summary. These are not filled from composite event counts.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Original Hb responders, mean changes, timepoints, denominators, missingness and durability material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original Hb responders, mean changes, timepoints, denominators, missingness and durability material.
Required materials and conditions: Original Hb responders, mean changes, timepoints, denominators, missingness and durability material.
Materials to obtain first: Original Hb responders, mean changes, timepoints, denominators, missingness and durability material.
Further research: Response magnitude and durability require direct detailed laboratory-outcome material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Are absolute Hb change, group responder counts and durability verified? Distinguish Original Hb responders, mean changes, timepoints, denominators, missingness and durability material in original material and retain unverified limits.
Why this condition is needed: Are absolute Hb change, group responder counts and durability verified? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N37 · Do baseline Hb/iron status and achieved ferritin link to outcomes?

Current findings: The target ferritin range is described, but group baseline Hb/iron status, achieved values, distributions and changes are unverified in the summary. Targets are not changed into actual measurements.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure.
Required materials and conditions: Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure.
Materials to obtain first: Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure.
Further research: Material presenting targets separately from achieved values is needed.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Do baseline Hb/iron status and achieved ferritin link to outcomes? Distinguish Original baseline/repeated Hb, ferritin and iron-status tables linked to exposure in original material and retain unverified limits.
Why this condition is needed: Do baseline Hb/iron status and achieved ferritin link to outcomes? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N38 · How much is known about composite components and group contributions?

Current findings: Overall composite events are retained, but additional-treatment-type events, contributions of consecutive-low-Hb, overlap, first events and recurrent-event counting are unverified in detail. Composite reduction is not extended to improvement in every component.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Component events, denominators, overlap, time, effects and planned comparisons is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Component events, denominators, overlap, time, effects and planned comparisons.
Required materials and conditions: Component events, denominators, overlap, time, effects and planned comparisons.
Materials to obtain first: Component events, denominators, overlap, time, effects and planned comparisons.
Further research: Material showing the composite alongside each component is needed.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: How much is known about composite components and group contributions? Distinguish Component events, denominators, overlap, time, effects and planned comparisons in original material and retain unverified limits.
Why this condition is needed: How much is known about composite components and group contributions? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N39 · Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit?

Current findings: Original material describes improved laboratory/treatment-decision surrogates. Direct symptom, quality-of-life or sustained post-follow-up benefits are absent from the summary and are not replaced by Hb response.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons.
Required materials and conditions: Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons.
Materials to obtain first: Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons.
Further research: Patient-important outcomes must link the question and evidence using separate direct material.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit? Distinguish Direct patient-reported outcomes, function, quality-of-life and long-term follow-up definitions/comparisons in original material and retain unverified limits.
Why this condition is needed: Do hemoglobin outcomes answer symptoms, quality of life or sustained patient benefit? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N40 · Do current dialysis observations clinically validate Hb response?

Current findings: Original wording reports 16 people overall (2.6%) starting dialysis over 56 weeks with no group difference. Group events, denominators, effects and CIs are unverified; insufficient power limits interpretation, so Hb response is not translated into reduced dialysis.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power.
Required materials and conditions: Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power.
Materials to obtain first: Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power.
Further research: Dialysis benefit requires direct comparisons designed to answer that clinical event adequately.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Do current dialysis observations clinically validate Hb response? Distinguish Group dialysis events, definitions, at-risk populations, denominators, follow-up, effects and power in original material and retain unverified limits.
Why this condition is needed: Do current dialysis observations clinically validate Hb response? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: The overall 16 people are not copied as events in each of two groups.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N41 · Do current mortality observations establish survival benefit?

Current findings: Deaths are retained as high-target 7/154 (4.5%) versus oral 15/312 (4.8%). Detailed death definitions, between-group estimates, CIs and power are absent; Hb improvement does not establish increased survival.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Death counting, causes, analysis populations, follow-up, between-group estimation and precision material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Death counting, causes, analysis populations, follow-up, between-group estimation and precision material.
Required materials and conditions: Death counting, causes, analysis populations, follow-up, between-group estimation and precision material.
Materials to obtain first: Death counting, causes, analysis populations, follow-up, between-group estimation and precision material.
Further research: Survival benefit needs sufficient follow-up and comparison material directly addressing death.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Do current mortality observations establish survival benefit? Distinguish Death counting, causes, analysis populations, follow-up, between-group estimation and precision material in original material and retain unverified limits.
Why this condition is needed: Do current mortality observations establish survival benefit? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No new mortality differences, risk ratios, P values or CIs are calculated.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N42 · What direct cardiovascular-event reduction material is unverified?

Current findings: The parent and clinical-event subclaim say reduced cardiovascular events cannot be concluded and the trial was not designed/powered to answer them. Current cardiovascular definitions, components, counts, denominators and CIs are absent. Absence of information is not changed to zero events or an established null effect.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up.
Required materials and conditions: Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up.
Materials to obtain first: Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up.
Further research: Cardiovascular benefits require material powered directly for those outcomes.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What direct cardiovascular-event reduction material is unverified? Distinguish Cardiovascular outcome plans, definitions, group events, effects, CIs and follow-up in original material and retain unverified limits.
Why this condition is needed: What direct cardiovascular-event reduction material is unverified? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N43 · What limits extension from hemoglobin-centred response to clinical events?

Current findings: Subclaim C and the improved-surrogate-composite note are retained. Laboratory/additional-treatment improvement is not extended to separate dialysis, mortality or cardiovascular-protection claims. Positive Hb response remains alongside unverified patient-event benefit.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Direct surrogate-clinical-outcome relationships and separate outcome material is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Direct surrogate-clinical-outcome relationships and separate outcome material.
Required materials and conditions: Direct surrogate-clinical-outcome relationships and separate outcome material.
Materials to obtain first: Direct surrogate-clinical-outcome relationships and separate outcome material.
Further research: Extension questions require added material directly measuring/testing patient events.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What limits extension from hemoglobin-centred response to clinical events? Distinguish Direct surrogate-clinical-outcome relationships and separate outcome material in original material and retain unverified limits.
Why this condition is needed: What limits extension from hemoglobin-centred response to clinical events? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N44 · Was the same strategy/outcome replicated in other independent research?

Current findings: The current direct evidence entry is one FIND-CKD report. Independent replication, new material or separate clinical-event trials of the same strategy are unverified within the current original material. Parent R1/I0 history is not changed into new independent-count certification.
Verification status: Unverified
Materials actually read: Summary read; external materials not read
Why unverified: Direct details are unverified within the current stored summary and unread external material. Bibliographic, registration and population independence with direct same-strategy/outcome comparisons is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Bibliographic, registration and population independence with direct same-strategy/outcome comparisons.
Required materials and conditions: Bibliographic, registration and population independence with direct same-strategy/outcome comparisons.
Materials to obtain first: Bibliographic, registration and population independence with direct same-strategy/outcome comparisons.
Further research: Added independent results first distinguish trial, report and population sharing.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: Was the same strategy/outcome replicated in other independent research? Distinguish Bibliographic, registration and population independence with direct same-strategy/outcome comparisons in original material and retain unverified limits.
Why this condition is needed: Was the same strategy/outcome replicated in other independent research? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: Stored-summary information is distinguished from unread external material; no numbers, effects or verdicts beyond the original text are created.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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N45 · What is preserved when formulation, population or duration changes, or material is corrected?

Current findings: Current scope is original high-ferritin-target intravenous iron versus oral iron over 56 weeks in nondialysis CKD anemia. Effects across other formulations, targets, populations or timepoints are not merged automatically; new stored summaries/corrections must be recorded as separate events.
Verification status: Partly verified
Materials actually read: Summary read; external materials not read
Why unverified: Some stored summary content is linked for presentation; external clinical confirmation/content review is not complete. Complete pre-change original text, new material versions and reasons for question/condition/observation changes is needed and remains subject to user review.
Reason for missing information: External abstracts, full texts, registration, plans and original tables remain unread; Complete pre-change original text, new material versions and reasons for question/condition/observation changes.
Required materials and conditions: Complete pre-change original text, new material versions and reasons for question/condition/observation changes.
Materials to obtain first: Complete pre-change original text, new material versions and reasons for question/condition/observation changes.
Further research: Added material separates condition-version changes from observation application and retains user-review requirements.
Remaining uncertainty: Missing information or unread external material does not mean zero effect/events, no paper, access failure or a new grade.
Conditions for verification: What is preserved when formulation, population or duration changes, or material is corrected? Distinguish Complete pre-change original text, new material versions and reasons for question/condition/observation changes in original material and retain unverified limits.
Why this condition is needed: What is preserved when formulation, population or duration changes, or material is corrected? This is needed to distinguish the direct scope of this question from other outcomes.
Application exceptions: No new searches, calculations, grades or treatment recommendations are run in this production.
Referenced methods: Family condition definitions linked to the stored summary; no official clinical-method assessment is run.

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