{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3119-main", "verdict_number": "3119", "title": "Single-ingredient oral ordinary thiamine (vitamin B1) × Endurance time-trial completion time in trained adults", "view_version": "1.0", "view_created_date": "2026-11-06", "criteria_version": "v3119-ORAL-THIAMINE-TRAINED-TT-1.1", "criteria_date": "2026-10-05", "review_date": "2026-10-05", "legacy_evidence_date": "2026-09-16", "review_scope": { "materials_read": "Stored Korean and English manuscripts and case-specific criteria and application records", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Reading stored summaries is distinguished from not reading external source materials or historical separate documents, while preserving the original verdict, numerical values and unverified information. No new clinical search, source reading, effect calculation or reassessment was performed.", "date_meaning": "This is the date the stored materials were checked, not the date of an up-to-date clinical literature search." }, "claim_context": { "population": "Trained adults. The actual eligible sport, training qualifications, inclusion/exclusion criteria and baseline thiamine status are unverified.", "intervention": "Single-ingredient oral ordinary thiamine. The free base, hydrochloride and mononitrate remain separate, and the actual eligible salt, product/batch/source are unverified. Equivalence to derivatives/combinations is not assumed.", "dose": "The eligible dose, frequency, meal timing/loading and adherence are unverified. Derivative/combination doses are not converted or transferred into personal dosing instructions.", "comparator": "Placebo, no added thiamine, or a control with all other treatments matched. The actual eligible composition and evidence of matching for concomitant treatments/training/diet are unverified.", "endpoint": "Completion time for one fixed-distance or fixed-work endurance time trial. Shorter is better. The actual eligible sport, protocol, distance/work, unit and principal time point are unverified.", "duration": "The eligible administration duration, actual exposure and principal time point are unverified. Each schedule in an indirect trial is attributed only to its respective product/endpoint.", "excluded_extensions": "Allithiamin/TTFD/fursultiamine/TPP, pantothenic-acid-related/multicomponent combinations, non-athletes/other cohorts, exhaustion/fixed-duration biochemistry/RPE, fatigue, VO2max/lactate, strength/gait, deficiency treatment, optimal dose/long-term outcomes, and judgments about personal safety/anti-doping compliance are separate questions." }, "requirements": [ { "item_id": "N01", "question_type": "Independent question", "question": "What is the performance-efficacy question in this table?", "needed": "The identity of the current claim and the boundaries of the population, single-ingredient oral exposure, matched control and completion time", "role": "Required", "role_reason": "Needed to avoid combining the entire B1 family or all exercise performance into one verified effect.", "application_exception": "The subclaim array is empty. Reports on related derivatives, combinations and other endpoints are not split into new primary tables of direct evidence.", "criterion": "Preserve the exact /ko/effect and link it to one question about trained adults, single-ingredient oral ordinary thiamine and fixed-distance/work completion time.", "basis": "C01: Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are locally designed / C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed. Reason for application in this case: Needed to avoid combining the entire B1 family or all exercise performance into one verified effect. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original claim with the actual population, intervention, control and endpoint, and record the inclusion/exclusion boundaries.", "current_reports": [], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The original claim is “Endurance time-trial completion time in trained adults.” It asks about fixed-distance or fixed-work completion time with single-ingredient oral ordinary thiamine versus a matched control. The subclaim array is empty, and other endpoints, derivatives and combinations are separated as related materials.", "condition_status": "Met", "status_reason": "Meets the criterion of recording the independent question's identity and boundaries for extensions. This does not mean that a performance effect or safety has been verified.", "missingness": "The actual sport, product, protocol and principal time point of an eligible trial", "uncertainty": "The materials/verification still needed are as follows: The actual sport, product, protocol and principal time point of an eligible trial. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The identity of the current claim and the boundaries of the population, single-ingredient oral exposure, matched control and completion time" }, { "item_id": "N02", "question_type": "Scope of eligible materials", "question": "What is the verification scope of 0 directly eligible families?", "needed": "The original search/access scope, candidate-specific grounds for inclusion/exclusion, and whether eligible results exist", "role": "Required", "role_reason": "Needed to avoid turning an unverified direct comparison into worldwide absence of studies, an effect of 0 or absence of human research.", "application_exception": "The existence of related human research differs from the existence of a trial eligible for the selected question about thiamine alone.", "criterion": "Preserve 0 directly eligible families together with any_human_study=true and absence_proven=false.", "basis": "C02: Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is a local application / C08: M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / E07: M04 §4.6.1–4.6.2, M15 §15.3.1; local application. Reason for application in this case: Needed to avoid turning an unverified direct comparison into worldwide absence of studies, an effect of 0 or absence of human research. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "In an authorized update, recheck question-specific selection criteria, candidate-specific reasons for inclusion/exclusion and the search scope.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Within the original verification scope through 2026-09-16, the number of directly eligible controlled efficacy trial families is recorded as 0. Related human research exists, and absence of studies has not been proven. This 0 is not transferred to an effect of 0 or R0.", "condition_status": "Partly verified", "status_reason": "The original scope and reasons for excluding candidates are retained, but the separate original search logs and the entire current literature were not newly cross-checked.", "missingness": "The original search logs and the actual identity and selection materials for additional eligible candidates", "uncertainty": "The materials/verification still needed are as follows: The original search logs and the actual identity and selection materials for additional eligible candidates. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The original search/access scope, candidate-specific grounds for inclusion/exclusion, and whether eligible results exist" }, { "item_id": "N03", "question_type": "Identity of ordinary thiamine", "question": "Which salts/products qualify as single-ingredient ordinary thiamine?", "needed": "Verification of the free base/hydrochloride/mononitrate identity, product, batch, manufacturing source and single-ingredient composition in an eligible trial", "role": "Required", "role_reason": "Needed to avoid using the shared B1 label as evidence of molecular/product equivalence or an effect of the ingredient alone.", "application_exception": "Allithiamin, TTFD/fursultiamine, TPP and combinations do not substitute for ordinary thiamine alone. The free base/hydrochloride/mononitrate are not automatically pooled either.", "criterion": "Distinguish single-ingredient oral ordinary thiamine in the original question from the unverified actual salt/product, and do not create converted derivative doses.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid using the shared B1 label as evidence of molecular/product equivalence or an effect of the ingredient alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the product's ingredient list with the trial's actual formulation and supply/batch records to establish the exposure to include.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The selected exposure is single-ingredient oral ordinary thiamine. The free base, hydrochloride and mononitrate remain separate, and the actual eligible salt, product and manufacturing source are unverified. Derivatives/combinations in related reports are not equated with ordinary thiamine alone.", "condition_status": "Unverified", "status_reason": "The actual salt/product identity in an eligible trial has not been obtained. Oral use and a single ingredient are boundaries of the question, not a verified trial product.", "missingness": "Records of the eligible product's molecule/salt, ingredients, batch and supply", "uncertainty": "The materials/verification still needed are as follows: Records of the eligible product's molecule/salt, ingredients, batch and supply. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Verification of the free base/hydrochloride/mononitrate identity, product, batch, manufacturing source and single-ingredient composition in an eligible trial" }, { "item_id": "N04", "question_type": "Trained population", "question": "Adults from which sport and with which training criteria are targeted?", "needed": "Sport, training qualifications, competition level, training volume/years, age/sex and inclusion/exclusion criteria in an eligible trial", "role": "Required", "role_reason": "Needed to avoid transferring data from highly trained cyclists or non-athletes to all trained adults.", "application_exception": "Mean VO2max is not a training eligibility threshold. The female group with physical-education/Taekwondo experience is not relabeled as untrained.", "criterion": "Separate the trained adults specified in the question, the actual population of each trial, and the unverified eligible sport/qualifications.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / E08: M03 §3.2.1–3.2.4; details of dose, persistence and effect modification are locally designed. Reason for application in this case: Needed to avoid transferring data from highly trained cyclists or non-athletes to all trained adults. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare recruitment, baseline characteristic tables and training qualifications, and record differences in applicability across sports.", "current_reports": [ "S01", "S02", "S04", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The sport and training qualification criteria of an eligible trial are unverified. S01 is recorded as highly trained cyclists, S02 as having unverified training qualifications, S04 as a female group with athletic experience, and S05 as non-athletes. These populations are not pooled as the same eligible group.", "condition_status": "Unverified", "status_reason": "Some descriptions of related populations exist, but sport, training criteria and selection materials eligible for the selected question are absent.", "missingness": "Eligible recruitment/exclusion, baseline characteristic and training qualification materials", "uncertainty": "The materials/verification still needed are as follows: Eligible recruitment/exclusion, baseline characteristic and training qualification materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Sport, training qualifications, competition level, training volume/years, age/sex and inclusion/exclusion criteria in an eligible trial" }, { "item_id": "N05", "question_type": "Baseline nutritional status", "question": "Have deficiency correction and performance in trained adults with different nutritional status been distinguished?", "needed": "Baseline thiamine markers/assays, thresholds, diet/energy availability, concomitant supplementation and deficiency-related selection", "role": "Required", "role_reason": "Needed to avoid extending deficiency improvement or blood-level categorization to additional performance benefits in nutritionally sufficient athletes.", "application_exception": "S03's blood-level division at 40 ng/mL is the authors' classification, not a universal diagnostic criterion for deficiency. A request to follow a normal diet does not verify adequate baseline B1.", "criterion": "Preserve unverified eligible baseline status and the limitations of markers/diet in related trials, and separate deficiency treatment from the performance question.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application / E08: M03 §3.2.1–3.2.4; details of dose, persistence and effect modification are locally designed. Reason for application in this case: Needed to avoid extending deficiency improvement or blood-level categorization to additional performance benefits in nutritionally sufficient athletes. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare baseline testing and diet/concomitant supplementation records with the presence of prespecified stratification or interaction analyses.", "current_reports": [ "S03", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Eligible baseline thiamine status is unverified. S03 uses the authors' classification based on blood B1 of 40 ng/mL, with 8 participants per group; this is not universal diagnostic confirmation of deficiency. S05's dietary management is likewise not relabeled as a result verifying adequate baseline B1 status.", "condition_status": "Unverified", "status_reason": "No materials establish baseline testing, nutritional status or deficiency status in the selected population.", "missingness": "Eligible baseline assay/value, diet, concomitant supplementation and deficiency selection materials", "uncertainty": "The materials/verification still needed are as follows: Eligible baseline assay/value, diet, concomitant supplementation and deficiency selection materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Baseline thiamine markers/assays, thresholds, diet/energy availability, concomitant supplementation and deficiency-related selection" }, { "item_id": "N06", "question_type": "Dose and frequency", "question": "What are the actual dose and administration frequency of an eligible single-ingredient product?", "needed": "Actual salt/active amount, dose per administration (1 time), total daily dose, frequency, meal timing/loading, adherence and concomitant exposure", "role": "Required", "role_reason": "Needed to avoid transferring a derivative or combination dose to a study dose or personal recommended dose for ordinary thiamine alone.", "application_exception": "Derivative mass is not converted to a thiamine-equivalent dose. Reported amounts of other products are attributed only to those products.", "criterion": "Retain null for eligible dose/frequency, and link doses and ambiguities in related reports to separate rows.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application / E08: M03 §3.2.1–3.2.4; details of dose, persistence and effect modification are locally designed. Reason for application in this case: Needed to avoid transferring a derivative or combination dose to a study dose or personal recommended dose for ordinary thiamine alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare actual administration with ingredient/active-amount records, and analyze any dose comparison as a separate prespecified question.", "current_reports": [ "S01", "S02", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The dose and administration frequency of eligible single-ingredient ordinary thiamine are unverified. Derivative amounts in g or mg/kg and the B1 content of combination tablets are not converted into equivalent doses, optimal doses or personal doses of thiamine alone.", "condition_status": "Unverified", "status_reason": "Actual dose, frequency and adherence records for the selected exposure are absent, and doses of related formulations cannot substitute for them.", "missingness": "Actual administration, active-amount, frequency and adherence records for the eligible product", "uncertainty": "The materials/verification still needed are as follows: Actual administration, active-amount, frequency and adherence records for the eligible product. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Actual salt/active amount, dose per administration (1 time), total daily dose, frequency, meal timing/loading, adherence and concomitant exposure" }, { "item_id": "N07", "question_type": "Duration and time point", "question": "Which completion time after which supplementation duration is being compared?", "needed": "Eligible supplementation duration, actual exposure, principal measurement time point, discontinuation/follow-up and reasons for selecting the duration", "role": "Required", "role_reason": "Needed to avoid pooling results after 3/4/7 days or 4 weeks with different formulations as effects at the same time point or sustained effects.", "application_exception": "Long-term studies are not unconditionally imposed as a requirement for a short completion-time question; long-term persistence of effects is a separate question.", "criterion": "Distinguish null eligible duration/principal time point from each duration/time point in related reports.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / E08: M03 §3.2.1–3.2.4; details of dose, persistence and effect modification are locally designed. Reason for application in this case: Needed to avoid pooling results after 3/4/7 days or 4 weeks with different formulations as effects at the same time point or sustained effects. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the administration schedule, measurement time points and planned principal time point, and design additional follow-up as a separate question about persistence.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The supplementation duration and principal time-trial time point for eligible ordinary thiamine are unverified. Short-term or 4-week administration in related trials is not pooled as the same time point or extended to persistence after discontinuation or an optimal duration.", "condition_status": "Unverified", "status_reason": "The actual supplementation duration and originally planned principal time point for the selected question are absent.", "missingness": "Eligible administration schedule, principal time point, discontinuation/follow-up and planning materials", "uncertainty": "The materials/verification still needed are as follows: Eligible administration schedule, principal time point, discontinuation/follow-up and planning materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible supplementation duration, actual exposure, principal measurement time point, discontinuation/follow-up and reasons for selecting the duration" }, { "item_id": "N08", "question_type": "Control and concomitant treatments", "question": "Are other treatments matched, with only added thiamine differing?", "needed": "Eligible control ingredients, diet/hydration/caffeine, training, concomitant supplementation, adherence/rescue treatment and changes by group/period", "role": "Required", "role_reason": "Needed to avoid attributing differences in diet, training or combined ingredients to an effect of thiamine alone.", "application_exception": "Do not require all treatment changes to be identical; distinguish the actual effect of interest and how changes are handled. A placebo label alone does not verify matching.", "criterion": "Separate the matched control specified in the question from the unverified actual eligible control/concomitant treatments.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid attributing differences in diet, training or combined ingredients to an effect of thiamine alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare control composition, diet/training by period, concomitant exposure and adherence records to examine the contribution of the single ingredient.", "current_reports": [ "S01", "S02", "S04", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The question concerns placebo, no added thiamine, or a control with other treatments matched. The actual eligible control and group-specific diet, training and adherence are unverified. S04's separate training period or the control for S05's combination tablet is not relabeled as a comparison of added thiamine alone.", "condition_status": "Unverified", "status_reason": "There are no actual control, concomitant-treatment or period-specific change materials that distinguish the contribution of an eligible single ingredient.", "missingness": "Eligible control composition, concomitant-treatment, diet/training and adherence/rescue-treatment records", "uncertainty": "The materials/verification still needed are as follows: Eligible control composition, concomitant-treatment, diet/training and adherence/rescue-treatment records. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible control ingredients, diet/hydration/caffeine, training, concomitant supplementation, adherence/rescue treatment and changes by group/period" }, { "item_id": "N09", "question_type": "Completion-time definition", "question": "Have fixed-distance/work completion time and time to exhaustion been distinguished?", "needed": "Eligible sport, fixed distance/work, principal completion time, unit, direction and prespecified endpoint definition", "role": "Required", "role_reason": "Needed to avoid transferring completion time, for which shorter is better, and time to exhaustion, for which longer is better, into the same outcome.", "application_exception": "Biochemistry/RPE during fixed 60-minute exercise, VO2max, lactate and subjective fatigue are not substitutes for completion time.", "criterion": "Retain lower_is_better=true for the selected endpoint and the unverified actual eligible protocol/unit, and separate outcomes with a different direction.", "basis": "C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / E03: M08 Table 8.2.a, M03 §3.2.4; local application / E09: M03 §3.2.4; locally defined boundaries for extensions. Reason for application in this case: Needed to avoid transferring completion time, for which shorter is better, and time to exhaustion, for which longer is better, into the same outcome. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare distance/work, stopping criteria, units and the prespecified endpoint list, and link only comparable completion times.", "current_reports": [ "S01", "S02", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The selected endpoint is the time to complete one fixed distance or fixed amount of work, and shorter is better. The actual eligible sport, distance/work and unit are unverified. Time to exhaustion, for which longer is better, is kept separate, as are fixed-duration biochemistry/RPE, subjective fatigue and VO2max/lactate.", "condition_status": "Partly verified", "status_reason": "The definition and direction of the selected endpoint are specified, but the actual protocol and measurement unit of an eligible trial are absent.", "missingness": "Eligible stopping criteria, distance/work, unit, principal time point and prespecified endpoint definition", "uncertainty": "The materials/verification still needed are as follows: Eligible stopping criteria, distance/work, unit, principal time point and prespecified endpoint definition. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible sport, fixed distance/work, principal completion time, unit, direction and prespecified endpoint definition" }, { "item_id": "N10", "question_type": "Measurement implementation", "question": "Were measurement conditions and learning effects from repeated testing controlled?", "needed": "Familiarization, warm-up, pacing, resistance/gradient, environment, equipment calibration, encouragement, time of day, hydration/feeding/caffeine", "role": "Required", "role_reason": "Needed because even objective records in seconds can be affected by differences in measurement implementation and learning effects across periods.", "application_exception": "Do not automatically judge objective records to be unbiased or fill unverified measurement procedures in as properly implemented.", "criterion": "Link unverified eligible implementation information and limitations of related reports to their locations.", "basis": "C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / E03: M08 Table 8.2.a, M03 §3.2.4; local application. Reason for application in this case: Needed because even objective records in seconds can be affected by differences in measurement implementation and learning effects across periods. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the measurement SOP with actual equipment/environment, familiarization and period-specific implementation records.", "current_reports": [ "S01", "S02", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The measurement SOP for an eligible time trial is unverified. In related S01/S02 reports, many implementation details, including familiarization, pacing, equipment calibration/environment, are also unverified. Matched measurement conditions are not assumed merely because time records are objective.", "condition_status": "Unverified", "status_reason": "There are no materials for cross-checking actual implementation, environment/calibration or learning effects for the selected endpoint.", "missingness": "Eligible measurement SOP and period-specific implementation/environment and familiarization records", "uncertainty": "The materials/verification still needed are as follows: Eligible measurement SOP and period-specific implementation/environment and familiarization records. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Familiarization, warm-up, pacing, resistance/gradient, environment, equipment calibration, encouragement, time of day, hydration/feeding/caffeine" }, { "item_id": "N11", "question_type": "Allocation process", "question": "Have actual allocation and concealment in the eligible comparison been verified?", "needed": "Parallel/crossover design, random sequence, allocation concealment and baseline/sequence balance in the selected comparison", "role": "Required", "role_reason": "Needed to avoid inheriting a related trial's randomized label as verification of allocation for causal inference in an as-yet-unselected eligible trial.", "application_exception": "Preserve the designs of related ineligible trials, but do not score bias in the effect of an eligible single-ingredient product on those designs alone.", "criterion": "Distinguish the absence of a selected eligible trial from unverified actual allocation/concealment, and assign no new RoB grade.", "basis": "E01: M08 §8.1–8.2.3; local application / C04: M03 §3.2.1; detailed population criteria are locally designed. Reason for application in this case: Needed to avoid inheriting a related trial's randomized label as verification of allocation for causal inference in an as-yet-unselected eligible trial. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the eligible protocol, sequence generation/concealment, and baseline and sequence-specific characteristics.", "current_reports": [ "S01", "S02", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "No directly eligible comparison has been selected, so its allocation, concealment and baseline balance are unverified. Descriptions of randomized crossover/sequences in S01/S02/S05 are records for their respective ineligible products and are not inherited as verification of allocation in a trial of thiamine alone.", "condition_status": "Unverified", "status_reason": "An eligible trial and actual allocation/concealment materials are absent, so no new bias judgment can be made.", "missingness": "Eligible design, sequence generation/concealment, and baseline/sequence characteristic materials", "uncertainty": "The materials/verification still needed are as follows: Eligible design, sequence generation/concealment, and baseline/sequence characteristic materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Parallel/crossover design, random sequence, allocation concealment and baseline/sequence balance in the selected comparison" }, { "item_id": "N12", "question_type": "Blinding", "question": "Have the actual blinding procedures and their success been verified?", "needed": "Participant/assessor blinding, placebo matching, actual unblinding and assessment of blinding", "role": "Required", "role_reason": "Needed to avoid turning a double-blind label into actual successful blinding or the absence of differences in encouragement/assessment.", "application_exception": "Inability to blind is not automatically judged a failure. S05's manufacturer assistance with placebo/blinding is recorded alongside its separate funding/product roles.", "criterion": "Separate unverified eligible blinding from the levels of verification/non-verification in related trials.", "basis": "E01: M08 §8.1–8.2.3; local application / E03: M08 Table 8.2.a, M03 §3.2.4; local application. Reason for application in this case: Needed to avoid turning a double-blind label into actual successful blinding or the absence of differences in encouragement/assessment. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare placebo composition, blinding implementation/unblinding, assessor roles and verified assessments.", "current_reports": [ "S01", "S02", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Blinding implementation for an eligible single-ingredient product is unverified. S05 records a placebo of the same color/size and manufacturer assistance with blinding, but no test of its success is verified. This description is not transferred into verification of blinding in a trial of thiamine alone.", "condition_status": "Unverified", "status_reason": "Related descriptions exist, but there are no blinding materials for the selected eligible comparison.", "missingness": "Eligible placebo/blinding implementation, unblinding and assessor materials", "uncertainty": "The materials/verification still needed are as follows: Eligible placebo/blinding implementation, unblinding and assessor materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Participant/assessor blinding, placebo matching, actual unblinding and assessment of blinding" }, { "item_id": "N13", "question_type": "Eligible denominators", "question": "Who was allocated, analyzed, completed or dropped out?", "needed": "Eligible allocation/analysis/completion, period-specific dropout, exclusions, analysis populations and reasons", "role": "Required", "role_reason": "Needed to avoid turning reported participant counts or repeated periods into eligible analysis denominators.", "application_exception": "Do not replace null direct results with 0 participants. Participant counts in S01/S02 do not represent separately verified analysis flow.", "criterion": "Retain null for eligible randomized_n/analyzed_n/completed_n and record what the related reported counts represent.", "basis": "C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E04: M08 §8.2.2, M15 §15.3.1; local application. Reason for application in this case: Needed to avoid turning reported participant counts or repeated periods into eligible analysis denominators. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare participant flow, those analyzed by period and reasons for missingness/exclusion to verify endpoint-specific denominators.", "current_reports": [ "S01", "S02", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Eligible allocated, analyzed and completed counts are all null. S01's 6 and S02's 14 are reported participant counts; separate analysis flow has not been verified. Ineligible population n or repeated periods are not imported as eligible analysis denominators.", "condition_status": "Unverified", "status_reason": "Actual participant flow and endpoint-specific analysis/missingness denominators for the selected question are absent.", "missingness": "Eligible participant flow, analysis population and period-specific missingness/exclusion materials", "uncertainty": "The materials/verification still needed are as follows: Eligible participant flow, analysis population and period-specific missingness/exclusion materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible allocation/analysis/completion, period-specific dropout, exclusions, analysis populations and reasons" }, { "item_id": "N14", "question_type": "Effect of interest in a crossover", "question": "Have pairing, period and carryover effects in the crossover trial been verified?", "needed": "Eligible effect of interest, sequence/period, washout, handling of carryover/learning, adherence, analysis model and paired variance", "role": "Required", "role_reason": "Needed to avoid converting marginal crossover summaries into an effect between two independent groups or a paired effect/CI.", "application_exception": "Do not replace an unverified eligible design with a designation that crossover design is not applicable. Preserve unique participants in ineligible crossover results.", "criterion": "Explain the unverified eligible estimand/model and the lack of pairing/carryover information in related crossovers.", "basis": "E04: M08 §8.2.2, M15 §15.3.1; local application / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed. Reason for application in this case: Needed to avoid converting marginal crossover summaries into an effect between two independent groups or a paired effect/CI. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original analysis plan with individual period/sequence data to assess the effect of interest and the suitability of handling period/carryover effects.", "current_reports": [ "S01", "S02", "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The design, effect of interest and model for an eligible comparison are unverified. Verification of paired variance and period/carryover effects is also limited in related crossover reports. Two periods from one participant are not counted as independent people, and a paired CI is not created from marginal summaries.", "condition_status": "Unverified", "status_reason": "Materials on the effect of interest and handling of pairing and period/carryover effects for the selected comparison have not been acquired.", "missingness": "Eligible SAP, individual period/sequence data, paired variance and model results", "uncertainty": "The materials/verification still needed are as follows: Eligible SAP, individual period/sequence data, paired variance and model results. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible effect of interest, sequence/period, washout, handling of carryover/learning, adherence, analysis model and paired variance" }, { "item_id": "N15", "question_type": "Direct effect", "question": "Has a completion-time effect of single-ingredient ordinary thiamine versus control been reported?", "needed": "Eligible endpoint-specific effect, CI/confidence level, P, unit, denominator and original table/model", "role": "Required", "role_reason": "Needed to avoid moving derivative or combination values into the primary-effect field and making a direct effect appear verified.", "application_exception": "Unverified null is not replaced with an effect of 0 or P=1, and indirect values are not pooled or subjected to new arithmetic.", "criterion": "Retain null for effect/CI/P/unit/n in primary_result and the eligible fact_capsule.", "basis": "C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E04: M08 §8.2.2, M15 §15.3.1; local application / E05: M15 §15.3.1–15.3.3; local application. Reason for application in this case: Needed to avoid moving derivative or combination values into the primary-effect field and making a direct effect appear verified. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Directly cross-check eligible original tables against the definition, denominator, unit and reported intervals of the model for the effect of interest.", "current_reports": [], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The eligible between-group completion-time effect, CI, P, denominator and unit for ordinary thiamine alone are all unverified. Indirect values from S01/S02/S05 are not moved into this primary-effect field, nor is it filled with new calculations.", "condition_status": "Unverified", "status_reason": "The original table/model and required numerical values for the selected direct effect are absent from the currently retained scope.", "missingness": "The eligible endpoint's original table/model, denominator/unit and effect/CI/P", "uncertainty": "The materials/verification still needed are as follows: The eligible endpoint's original table/model, denominator/unit and effect/CI/P. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible endpoint-specific effect, CI/confidence level, P, unit, denominator and original table/model" }, { "item_id": "N16", "question_type": "Precision and importance", "question": "Can a nonsignificant result be interpreted as no effect or equivalence?", "needed": "The eligible effect's CI, paired variance, prespecified important-difference/equivalence criteria and supporting justification", "role": "Required", "role_reason": "Needed to avoid establishing an effect size as sufficient, absent or equivalent from P values and small sample sizes alone.", "application_exception": "Do not invent an unsupported common MCID, minimum n, number of trials or duration. Do not fill in unverified parenthetical dispersion as SD/SE.", "criterion": "Separate nonsignificance at P=0.58/0.61 from absence of effect/equivalence, and retain unverified direct precision/importance.", "basis": "E05: M15 §15.3.1–15.3.3; local application / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed. Reason for application in this case: Needed to avoid establishing an effect size as sufficient, absent or equivalent from P values and small sample sizes alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare reported intervals with verified prespecified criteria for performance importance, and record the limits to interpretation.", "current_reports": [ "S01", "S02" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Nonsignificant P values in S01/S02 do not verify absence of effect or equivalence for ordinary thiamine. The direct effect's CI and criteria for performance importance are unverified. Without the dispersion type of marginal summaries and paired variance, no new CI or precision grade is created.", "condition_status": "Unverified", "status_reason": "Without a direct interval and justified importance/equivalence criteria, the range of effects compatible with the evidence cannot be judged.", "missingness": "Eligible CI, paired variance and prespecified importance/equivalence criteria", "uncertainty": "The materials/verification still needed are as follows: Eligible CI, paired variance and prespecified importance/equivalence criteria. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The eligible effect's CI, paired variance, prespecified important-difference/equivalence criteria and supporting justification" }, { "item_id": "N17", "question_type": "S01 product and population", "question": "What are the product and exposure in the closest report on trained cyclists?", "needed": "S01's original formulation, composition, administration, trained population/baseline characteristics and information on the ingredient's contribution alone", "role": "Required", "role_reason": "Needed to avoid relabeling a derivative combination as a trial of ordinary thiamine alone because it is a TT in a closely related trained population.", "application_exception": "ordinary_thiamine=false denies the product's eligibility as single-ingredient ordinary thiamine; it does not mean the combination contains no B1-family ingredient.", "criterion": "Link the allithiamin+pantothenic-acid-related combination, reported dose/7 days, trained cyclist population and reasons for exclusion.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid relabeling a derivative combination as a trial of ordinary thiamine alone because it is a TT in a closely related trained population. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original product/methods with the existence of an actual contrast that isolates the ingredient's contribution.", "current_reports": [ "S01" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S01 concerns an allithiamin+pantethine/pantothenic-acid-related combination in highly trained cyclists. It records daily allithiamin 1 g and a pantothenic-acid-related compound 1.8 g (55:45), administered orally for 7 days before each ride. It is not a contrast isolating the contribution of ordinary thiamine alone.", "condition_status": "Met", "status_reason": "Meets the criterion of preserving the attribution of product, population and reported dose, and the boundary for exclusion from direct eligibility. This is not verification of an effect of the ingredient alone.", "missingness": "A contrast isolating the ingredient's contribution alone and the complete actual product/methods information", "uncertainty": "The materials/verification still needed are as follows: A contrast isolating the ingredient's contribution alone and the complete actual product/methods information. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S01's original formulation, composition, administration, trained population/baseline characteristics and information on the ingredient's contribution alone" }, { "item_id": "N18", "question_type": "S01 TT values", "question": "Have the status of S01's time summaries and historical arithmetic been preserved?", "needed": "S01's original TT protocol, numerical sentence, mean/dispersion type, paired analysis/CI and flow", "role": "Required", "role_reason": "Needed to avoid promoting marginal summaries and the simple difference recorded at retention into a direct ordinary-thiamine effect or paired estimate.", "application_exception": "Do not infer that the parenthetical 8.4/10.2 are SD or SE. −7.5 seconds is historical descriptive arithmetic, not a new calculation in this review.", "criterion": "Preserve the 50 km preload followed by a 2,000 m TT, 178.2(8.4)/170.7(10.2) seconds, P=0.58 and reported n=6 together with unverified dispersion/CI.", "basis": "C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E04: M08 §8.2.2, M15 §15.3.1; local application / E05: M15 §15.3.1–15.3.3; local application. Reason for application in this case: Needed to avoid promoting marginal summaries and the simple difference recorded at retention into a direct ordinary-thiamine effect or paired estimate. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original numerical sentence, endpoint time point and paired model/variance materials to distinguish descriptive summaries from the effect of interest.", "current_reports": [ "S01" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S01 uses a TT in which riding at approximately 60% VO2max for 50 km is followed by completing 2,000 m. Placebo is 178.2(8.4) seconds, the combination 170.7(10.2) seconds, P=0.58, and reported participating n=6. The central-tendency/parenthetical dispersion types and paired CI are unverified. The original record's −7.5 seconds is descriptive arithmetic, not an effect of thiamine alone or a new calculation in this review.", "condition_status": "Partly verified", "status_reason": "The protocol and marginal numerical sentence are recorded, but analysis flow, central-tendency/dispersion types and paired effect/CI are unverified.", "missingness": "S01 original tables/methods, analysis flow and paired model/variance", "uncertainty": "The materials/verification still needed are as follows: S01 original tables/methods, analysis flow and paired model/variance. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S01's original TT protocol, numerical sentence, mean/dispersion type, paired analysis/CI and flow" }, { "item_id": "N19", "question_type": "S02 formulation and exposure", "question": "How are S02's TTFD dose, duration and route distinguished?", "needed": "S02 TTFD identity, product, administration route, daily dose/duration, washout and actual training criteria", "role": "Required", "role_reason": "Needed to avoid transferring a TTFD dose or the label supplement into verification of oral ordinary-thiamine exposure.", "application_exception": "The route is null in the original structure. Oral administration is not inferred from the word supplementation or from the washout.", "criterion": "Preserve TTFD 1 g/day, 4 days per period and a 10-day washout, with unverified route/training qualifications.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid transferring a TTFD dose or the label supplement into verification of oral ordinary-thiamine exposure. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original administration methods and selection/training criteria, and record eligibility differences from ordinary thiamine alone.", "current_reports": [ "S02" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S02 reports TTFD 1 g/day administered for 4 days per period with a 10-day washout. Route and actual training qualification criteria are unverified. TTFD is not relabeled as ordinary thiamine alone, and oral administration is not inferred.", "condition_status": "Partly verified", "status_reason": "The derivative and reported administration schedule are recorded, but verification of route, product/training criteria is limited.", "missingness": "S02 original administration methods, product and selection/training criteria", "uncertainty": "The materials/verification still needed are as follows: S02 original administration methods, product and selection/training criteria. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S02 TTFD identity, product, administration route, daily dose/duration, washout and actual training criteria" }, { "item_id": "N20", "question_type": "S02 timing and values", "question": "Are S02's TT and the preceding day's exhaustion test the same endpoint?", "needed": "Definitions and values/central tendency, dispersion/denominators and paired analyses for S02's day 4 TT and day 3 progressive exhaustion test", "role": "Required", "role_reason": "Needed to avoid pooling different tests and nonsignificant time summaries in the same paper as one direct performance effect.", "application_exception": "The 14 are unique reported participants; the two crossover periods are not counted as 28 people. Whether the parenthetical 5.5/4.3 are SD/SE is unverified.", "criterion": "Separate the day 4, 2,000 m TT values of placebo 204.5(5.5) seconds, TTFD 200.9(4.3) seconds and P=0.61 from the day 3 exhaustion test.", "basis": "C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E04: M08 §8.2.2, M15 §15.3.1; local application / E05: M15 §15.3.1–15.3.3; local application. Reason for application in this case: Needed to avoid pooling different tests and nonsignificant time summaries in the same paper as one direct performance effect. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original schedule with each endpoint's numerical sentence, denominator and paired model to attribute results to their respective tests.", "current_reports": [ "S02" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S02's day 4, 2,000 m TT is separate from the day 3 progressive exhaustion test. TT values are placebo 204.5(5.5) seconds, TTFD 200.9(4.3) seconds, P=0.61, and reported participating n=14. Central-tendency/dispersion types, paired CI and separate analysis flow are unverified, and the two periods are not counted as 28 people.", "condition_status": "Partly verified", "status_reason": "The test schedule and marginal values are recorded, but central-tendency/dispersion types, paired estimation and actual analysis flow are unverified.", "missingness": "S02 endpoint-specific original tables/schedule, paired model and participant flow", "uncertainty": "The materials/verification still needed are as follows: S02 endpoint-specific original tables/schedule, paired model and participant flow. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Definitions and values/central tendency, dispersion/denominators and paired analyses for S02's day 4 TT and day 3 progressive exhaustion test" }, { "item_id": "N21", "question_type": "S03 fatigue and blood-level classification", "question": "Is S03's favorable fatigue report a completion-time effect?", "needed": "S03 original formulation/route, blood-level classification, fatigue/biochemical measurements, values and whether a standardized TT exists", "role": "Required", "role_reason": "Needed to avoid omitting favorable fatigue/metabolic reports or transferring them into a direct positive effect on fixed-distance completion time.", "application_exception": "Distinguish the keyword fursultiamine/TTFD from the unverified product in the full text. The blood-level division at 40 ng/mL is not a universal diagnostic criterion for deficiency.", "criterion": "Preserve the 16 male athlete volunteers, 100 mg/day for 3 days, and the authors' blood-level classification/favorable fatigue report, while leaving route and standardized TT effect unverified.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / E09: M03 §3.2.4; locally defined boundaries for extensions. Reason for application in this case: Needed to avoid omitting favorable fatigue/metabolic reports or transferring them into a direct positive effect on fixed-distance completion time. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare original product/methods, classification criteria and fatigue/metabolic results, and verify their differences from the completion-time endpoint.", "current_reports": [ "S03" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S03 provides fatigue/metabolic data for 16 male athlete volunteers at a reported dose of 100 mg/day for 3 days. Fursultiamine/TTFD is verified in the keywords, but the full-text product and route are unverified. The authors' classification at a blood level of 40 ng/mL into groups of 8 and favorable fatigue/metabolic reports are preserved without transferring them to a standardized TT effect.", "condition_status": "Partly verified", "status_reason": "Population, reported dose and fatigue context are available, but product/route and the selected completion-time result have not been verified.", "missingness": "S03 original product/methods, blood-level classification and complete fatigue/metabolic results", "uncertainty": "The materials/verification still needed are as follows: S03 original product/methods, blood-level classification and complete fatigue/metabolic results. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S03 original formulation/route, blood-level classification, fatigue/biochemical measurements, values and whether a standardized TT exists" }, { "item_id": "N22", "question_type": "S04 population and other endpoints", "question": "What are the results in S04's female population with athletic experience?", "needed": "S04 selection/athletic experience, crossover periods, TTFD/training/placebo, fixed-duration measurements and each result", "role": "Required", "role_reason": "Needed to avoid mislabeling a population with athletic experience as untrained or turning biochemical/RPE results into a completion-time effect.", "application_exception": "The training and TTFD periods are separate crossover treatments. Do not assign the TT completion-time direction to a fixed 60-minute test.", "criterion": "Distinguish the 9 women, physical-education/athletic and Taekwondo experience, oral TTFD, and biochemistry/RPE during fixed 60-minute exercise.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application / E09: M03 §3.2.4; locally defined boundaries for extensions. Reason for application in this case: Needed to avoid mislabeling a population with athletic experience as untrained or turning biochemical/RPE results into a completion-time effect. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare selection criteria, the three crossover treatments and measurement schedule/stopping criteria to verify the attribution of each result.", "current_reports": [ "S04" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S04 comprises 9 women with physical-education/athletic and Taekwondo experience. The three crossover treatments of oral TTFD, placebo and training are distinguished. It records exercise at 70% VO2max and 50 rpm for 60 minutes with biochemical/RPE measurements, so even favorable results do not represent a direct effect on fixed-distance TT completion time.", "condition_status": "Met", "status_reason": "Meets the record criterion of preserving the boundaries of the actual population and treatments/other endpoints. This does not mean that the original plan and every result have been fully cross-checked.", "missingness": "S04 selection, each crossover treatment/period and complete original biochemical/RPE results", "uncertainty": "The materials/verification still needed are as follows: S04 selection, each crossover treatment/period and complete original biochemical/RPE results. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S04 selection/athletic experience, crossover periods, TTFD/training/placebo, fixed-duration measurements and each result" }, { "item_id": "N23", "question_type": "S04 dose ambiguity", "question": "Can S04's 10 mg/kg and three administrations be converted?", "needed": "S04 original dose sentence, dose per administration (1 time)/total daily dose, actual administration and product/duration records", "role": "Required", "role_reason": "Needed to avoid repairing an ambiguous dose expression into an arbitrary daily dose or thiamine-equivalent dose.", "application_exception": "Do not multiply 10 mg/kg by 3 or by mean body weight based on the wording three administrations. Do not turn ambiguity into a newly established conflict between verified opposing facts.", "criterion": "Retain the records of 10 mg/kg, three administrations, 30 minutes after meals/150 mL water and 4 weeks, together with unverified total dose/dose per administration (1 time).", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid repairing an ambiguous dose expression into an arbitrary daily dose or thiamine-equivalent dose. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original dose sentence with actual administration records to verify the definitions of total daily dose and divided amounts.", "current_reports": [ "S04" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S04 records 10 mg/kg and three administrations, 30 minutes after meals, 150 mL water and 4 weeks. It is ambiguous whether 10 mg/kg is a divided total daily dose or the amount at each administration. No multiplication by 3, body-weight conversion or thiamine-equivalent calculation is performed, and the original conflicting_or_ambiguous wording is preserved.", "condition_status": "Partly verified", "status_reason": "The dose sentence is available, but its meaning as total daily dose/amount at each administration has not been verified. The ambiguity has not been arbitrarily resolved.", "missingness": "S04 original dose sentence and actual dose per administration (1 time)/total daily dose and administration records", "uncertainty": "The materials/verification still needed are as follows: S04 original dose sentence and actual dose per administration (1 time)/total daily dose and administration records. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S04 original dose sentence, dose per administration (1 time)/total daily dose, actual administration and product/duration records" }, { "item_id": "N24", "question_type": "S05 combination composition", "question": "Does S05's B1 content constitute a contrast of added B1 alone?", "needed": "All Ex PLUS ingredients/salts, product, daily tablets, duration, concomitant exposure and a contrast isolating the ingredient's contribution", "role": "Required", "role_reason": "Needed to avoid reattributing an effect of a combination containing B1 to B1 alone.", "application_exception": "ordinary_thiamine=false denies eligibility as single-ingredient ordinary thiamine; it does not mean that no B1 molecules are present.", "criterion": "Preserve all reported ingredients in addition to B1 33.6 mg, and label it as a combination product taken at 1 tablet daily for 28 days per period.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E02: M03 §3.2.3, M08 §8.2.2–8.2.3; local application. Reason for application in this case: Needed to avoid reattributing an effect of a combination containing B1 to B1 alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare all ingredient/product records with the actual control to examine whether the trial isolated the contribution of a single ingredient.", "current_reports": [ "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05 uses the oral Ex PLUS combination, 1 tablet daily for 28 days per period. Each tablet is recorded as containing B1 33.6 mg, B2 10 mg, B6 50 mg, B12 750 μg, E 16.8 mg, inositol 20 mg, calcium 18.9 mg and taurine 20 mg. This is not a contrast isolating the contribution of B1 alone.", "condition_status": "Met", "status_reason": "Meets the criterion of preserving the combination composition, exposure and limits on attributing a contribution to a single ingredient. This is not verification of an effect of B1 alone.", "missingness": "Product/salt and an actual contrast isolating the contribution of B1 alone", "uncertainty": "The materials/verification still needed are as follows: Product/salt and an actual contrast isolating the contribution of B1 alone. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "All Ex PLUS ingredients/salts, product, daily tablets, duration, concomitant exposure and a contrast isolating the ingredient's contribution" }, { "item_id": "N25", "question_type": "S05 denominator and time to exhaustion", "question": "How are S05's 32 participants and time to exhaustion preserved?", "needed": "Unique participants, sequence/period, washout, non-athlete selection, and the exhaustion result's mean/SD/direction and CI", "role": "Required", "role_reason": "Needed to avoid counting two periods as 64 people or displaying time to exhaustion, for which longer is better, as a TT, for which shorter is better.", "application_exception": "Combination results in non-athletes are not a direct effect of a single-ingredient product in trained adults. Reported SD is retained but not transferred to a paired SD/CI.", "criterion": "Attribute the 32 unique participants, initial sequences of 16/16, 14-day washout, and placebo 12.56±1.9 minutes/combination 15.82±1.91 minutes with P<0.0001 to the respective exhaustion endpoint.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E04: M08 §8.2.2, M15 §15.3.1; local application / E05: M15 §15.3.1–15.3.3; local application. Reason for application in this case: Needed to avoid counting two periods as 64 people or displaying time to exhaustion, for which longer is better, as a TT, for which shorter is better. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare participant flow and crossover schedule with the units, direction and dispersion in Figure 4/results.", "current_reports": [ "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05 has 32 unique non-athletes, initial sequences of 16/16, 28 days per period and a 14-day washout. Time to exhaustion is placebo 12.56±SD 1.9 minutes and combination 15.82±SD 1.91 minutes, P<0.0001, with longer being better. The 32 unique participants are not counted as 64, and the completed count and paired CI are unverified.", "condition_status": "Partly verified", "status_reason": "The unique denominator, exhaustion results and reported SD are available, but completion flow, paired interval and period-specific missingness are unverified.", "missingness": "S05 flow/period-specific missingness, Figure 4 original results and paired interval", "uncertainty": "The materials/verification still needed are as follows: S05 flow/period-specific missingness, Figure 4 original results and paired interval. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Unique participants, sequence/period, washout, non-athlete selection, and the exhaustion result's mean/SD/direction and CI" }, { "item_id": "N26", "question_type": "S05 analysis", "question": "Can repeated-measures ANOVA and marginal SD establish a paired effect?", "needed": "S05 SAP, repeated-measures/period/sequence/carryover model, Bonferroni/multiplicity and paired variance/CI", "role": "Required", "role_reason": "Needed to avoid turning a significant combination exhaustion result into verification of adequate paired estimation or direct precision.", "application_exception": "Do not generalize the record of some unpaired between-group tests to the analysis of every endpoint. Paired variance differs from marginal SD.", "criterion": "Distinguish two-way repeated-measures ANOVA+Bonferroni for exhaustion from unverified actual period/carryover handling and paired CI.", "basis": "E04: M08 §8.2.2, M15 §15.3.1; local application / E05: M15 §15.3.1–15.3.3; local application / E06: M08 Table 8.2.a, M04 §4.6.3; local application. Reason for application in this case: Needed to avoid turning a significant combination exhaustion result into verification of adequate paired estimation or direct precision. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original model for the exhaustion result with the SAP and period/sequence data to verify the scope of the paired structure and handling of multiplicity.", "current_reports": [ "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05 uses repeated-measures ANOVA, and some between-group tests are recorded as unpaired. Two-way repeated-measures ANOVA and Bonferroni post hoc tests are linked to exhaustion. Actual handling of period/carryover effects, multiplicity across all endpoints and paired variance/CI are unverified; no new paired interval is calculated from marginal SD.", "condition_status": "Partly verified", "status_reason": "Some analysis methods are verified, but full cross-checking of the SAP and period/carryover, multiplicity/paired estimation remains outstanding.", "missingness": "S05 SAP, original exhaustion model, period/sequence and paired variance", "uncertainty": "The materials/verification still needed are as follows: S05 SAP, original exhaustion model, period/sequence and paired variance. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S05 SAP, repeated-measures/period/sequence/carryover model, Bonferroni/multiplicity and paired variance/CI" }, { "item_id": "N27", "question_type": "S06 TPP and physiological endpoints", "question": "Are S06's TPP and physiological results an oral ordinary-thiamine TT?", "needed": "TPP product, 1 mg/kg administration schedule/route, saline control, training qualifications and physiological endpoints", "role": "Required", "role_reason": "Needed to avoid inferring that TPP and a saline control verify oral ordinary thiamine or transferring physiological results to completion time.", "application_exception": "Do not infer administration route from a 0.9% saline control alone. The 27 are reported participants; separate analysis flow is unverified.", "criterion": "Preserve TPP 1 mg/kg, unverified route/schedule, lactate/VO2max/heart-rate results and an unverified standardized TT.", "basis": "C04: M03 §3.2.1; detailed population criteria are locally designed / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C06: M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / E09: M03 §3.2.4; locally defined boundaries for extensions. Reason for application in this case: Needed to avoid inferring that TPP and a saline control verify oral ordinary thiamine or transferring physiological results to completion time. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original product, administration methods and physiological measurements/schedule to record eligibility differences in exposure and outcomes.", "current_reports": [ "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S06 reports on 27 male athletes receiving TPP 1 mg/kg. Actual administration schedule, route, training qualifications/analysis flow are unverified. Route is not inferred from the 0.9% saline control, and favorable lactate, VO2max and heart-rate context is not turned into a TT completion-time effect.", "condition_status": "Partly verified", "status_reason": "Product/reported dose and other physiological endpoints are recorded, but route, schedule and denominator/actual TT materials are unverified.", "missingness": "S06 original administration/selection, flow and complete physiological results", "uncertainty": "The materials/verification still needed are as follows: S06 original administration/selection, flow and complete physiological results. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "TPP product, 1 mg/kg administration schedule/route, saline control, training qualifications and physiological endpoints" }, { "item_id": "N28", "question_type": "Study families", "question": "Have reports been distinguished from counts of unique trials/people?", "needed": "Original reports, copies/bibliographic records, participant overlap and cohort independence for the six excluded families", "role": "Required", "role_reason": "Needed to avoid counting abstracts/copies/reviews of the same trial as independent replications or merging them based on shared authors alone.", "application_exception": "Whether S01 and S02 are the same cohort is unverified. Shared authors are not evidence of identity or independence.", "criterion": "Distinguish retained F01–F06 from the 11 materials, and do not newly assign unique eligible replications or pooled n.", "basis": "C02: Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is a local application / E07: M04 §4.6.1–4.6.2, M15 §15.3.1; local application / H07: M04 §4.6.1–4.6.2; adaptations for harm materials are locally designed. Reason for application in this case: Needed to avoid counting abstracts/copies/reviews of the same trial as independent replications or merging them based on shared authors alone. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare original recruitment/participants, trial timing, authors/registration and report links to record family relationships and unverified overlap.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06", "S07", "S11" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The originally retained families F01–F06 are all excluded from direct eligibility. Abstracts, publisher entries/copies and reviews are not new trials/people. Cohort identity between S01 and S02 has not been verified, and shared authors alone do not establish identity or independence. No new pooled n or independent replication count is created.", "condition_status": "Partly verified", "status_reason": "Original family/report links exist, but verification of cohort overlap and all aspects of independence remains outstanding.", "missingness": "Original recruitment/participant, trial timing and report/cohort linkage materials", "uncertainty": "The materials/verification still needed are as follows: Original recruitment/participant, trial timing and report/cohort linkage materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original reports, copies/bibliographic records, participant overlap and cohort independence for the six excluded families" }, { "item_id": "N29", "question_type": "Role of the review", "question": "Is the S07 review a new performance trial of the ingredient alone?", "needed": "S07 review links to original trials/formulations and report citations, and the verification scope of the relevant sections", "role": "Supplementary", "role_reason": "Needed to avoid displaying the review's B1 shorthand as direct replication that erases differences in original formulations/combinations and endpoints.", "application_exception": "The review is material for discovery/context; its original study_id null is not assigned a new clinical family identity.", "criterion": "Link citations in the review to the original derivative/combination reports, without counting them as additional trials/denominators.", "basis": "C02: Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is a local application / C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / E07: M04 §4.6.1–4.6.2, M15 §15.3.1; local application. Reason for application in this case: Needed to avoid displaying the review's B1 shorthand as direct replication that erases differences in original formulations/combinations and endpoints. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the review's citations with the actual formulations, populations and endpoints in the original materials to record citation relationships.", "current_reports": [ "S07", "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S07 is a review of thiamine and carbohydrate metabolism, with historical HTML/PDF access and visual checking of some pages recorded. Its original study_id is null. The shorthand citation B1 is not equated with the original trials' derivatives/combinations/other endpoints, and the review itself is not counted as a new trial, person or direct replication.", "condition_status": "Met", "status_reason": "Meets the record criterion of preserving the review's discovery/context role and limits of citation reuse. This does not mean that the full review has been read in the current review.", "missingness": "Materials linking review citations to the original trials' actual formulations/endpoints", "uncertainty": "The materials/verification still needed are as follows: Materials linking review citations to the original trials' actual formulations/endpoints. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S07 review links to original trials/formulations and report citations, and the verification scope of the relevant sections" }, { "item_id": "N30", "question_type": "Registry shell", "question": "Do the S11 link and the date stated in the article prove prospective registration?", "needed": "NCT05586295 complete official record, first submission/registration, study start, version history and planned endpoints/SAP", "role": "Required", "role_reason": "Needed to avoid promoting a registration number or shell into verification of prospective registration, endpoint hierarchy or actual planned content.", "application_exception": "Preserve S05's 09/12/2022 as the original string without arbitrarily interpreting the date format. S11 links to the plan for the same F05 and is not a new trial.", "criterion": "Separate the historical 11-line shell from unverified first registration/study start and prospective registration/hierarchy.", "basis": "C02: Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is a local application / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / E06: M08 Table 8.2.a, M04 §4.6.3; local application. Reason for application in this case: Needed to avoid promoting a registration number or shell into verification of prospective registration, endpoint hierarchy or actual planned content. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the complete official change history with initial recruitment/submission and endpoint/SAP versions to examine the relationship between plans and reporting.", "current_reports": [ "S05", "S11" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05 states NCT05586295 and 09/12/2022; S11 records verification of only an 11-line shell at that time. First submission/study start, version history, prospective registration and endpoint hierarchy are unverified. The date format is not newly interpreted, and the registration link for the same F05 is not counted as an independent trial.", "condition_status": "Partly verified", "status_reason": "The number/article date and limited shell are available, but the complete official history and planned content have not been verified.", "missingness": "F05 complete official registration/change history, initial recruitment/submission and protocol/SAP", "uncertainty": "The materials/verification still needed are as follows: F05 complete official registration/change history, initial recruitment/submission and protocol/SAP. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "NCT05586295 complete official record, first submission/registration, study start, version history and planned endpoints/SAP" }, { "item_id": "N31", "question_type": "Planning and selective reporting", "question": "Have the planned endpoints and reports of each related family been cross-checked?", "needed": "Original registration, protocol, SAP, endpoint hierarchy/time points and reasons for changes for eligible/related families", "role": "Required", "role_reason": "Needed to avoid turning unacquired plans into confirmed non-registration or selective reporting.", "application_exception": "Limitations of the plan audit for related families are not a new bias grade for an eligible single-ingredient product. Do not arbitrarily assign an endpoint hierarchy.", "criterion": "Preserve the unverified original plans and the scope within which selective reporting cannot be cross-checked.", "basis": "E06: M08 Table 8.2.a, M04 §4.6.3; local application / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design. Reason for application in this case: Needed to avoid turning unacquired plans into confirmed non-registration or selective reporting. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare plan versions with actual results' endpoints, time points, analyses and reasons for changes.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06", "S11" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The six related families are recorded as having limited verification of registration/protocols and endpoint hierarchy, preventing definitive comparison of planned outcomes with the selection of reported results. This is not turned into confirmed non-registration, selective reporting or a new bias grade for eligible thiamine alone.", "condition_status": "Unverified", "status_reason": "There are insufficient materials to compare the original plan and analysis versions with actual reporting.", "missingness": "Family-specific registration, protocol/SAP and endpoint hierarchy/change materials", "uncertainty": "The materials/verification still needed are as follows: Family-specific registration, protocol/SAP and endpoint hierarchy/change materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original registration, protocol, SAP, endpoint hierarchy/time points and reasons for changes for eligible/related families" }, { "item_id": "N32", "question_type": "Funding, products and conflicts of interest", "question": "How are company support and independence distinguished?", "needed": "Family-specific funding, product/placebo supply, analysis/author roles, employment/conflicts of interest and independence", "role": "Required", "role_reason": "Needed to avoid omitting supply/support records or establishing independence solely from declarations/affiliations.", "application_exception": "Company support alone does not lead to automatic exclusion. The absence of a printed company affiliation is not filled in as absence of employment or verified independence.", "criterion": "Preserve S05's company+public funding, product/blinding assistance and conflict-of-interest declaration together with unverified information for other families.", "basis": "C10: Chamgap's own independence/attribution criteria. The official method sections used in this pilot do not validate every detail of these items / E07: M04 §4.6.1–4.6.2, M15 §15.3.1; local application. Reason for application in this case: Needed to avoid omitting supply/support records or establishing independence solely from declarations/affiliations. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare funding/supply, analysis/author roles and conflict-of-interest statements to record verified pathways of influence and gaps.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05 records Prince Pharmaceutical funding and product/blinding assistance alongside public funding from Taiwan, MOST-109-2622-H-179-001, and a declaration of no known competing interests. An unlisted company affiliation does not verify absence of employment or independence. Funding/supply information for other families is unverified.", "condition_status": "Partly verified", "status_reason": "S05's support/declaration is available, but actual analysis/employment roles, independence and funding information for other families remain to be verified.", "missingness": "Family-specific funding, supply, analysis/author/employment roles and conflict-of-interest materials", "uncertainty": "The materials/verification still needed are as follows: Family-specific funding, supply, analysis/author/employment roles and conflict-of-interest materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Family-specific funding, product/placebo supply, analysis/author roles, employment/conflicts of interest and independence" }, { "item_id": "N33", "question_type": "Scope of corrections and retractions", "question": "What is the scope of the historical record that no notice was found?", "needed": "Family-specific correction/retraction check logs, publisher/PMC notices, DOI and cutoff date/version", "role": "Required", "role_reason": "Needed to avoid turning the failure to find a notice in limited historical checks into certification that no notices currently exist.", "application_exception": "Distinguish the historical partial checks of S01/S02/S04/S05 from the unverified scope of S03/S06. There are no publisher/DOI lookups in this review.", "criterion": "Display the limits of none_located_in_checked_sources together with the absence of an external access attempt in the current review.", "basis": "C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design. Reason for application in this case: Needed to avoid turning the failure to find a notice in limited historical checks into certification that no notices currently exist. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "In an authorized update, compare actual sources checked, dates/versions and notices' effects on the respective reports/results.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The record states that no correction/retraction notices were found in the sources checked at that time for S01/S02/S04/S05, but does not guarantee absence of notices. The verification scope of other families is also limited. The currently retained corrections array is empty, but no new up-to-date publisher/DOI search or full-text recheck was performed in this review.", "condition_status": "Partly verified", "status_reason": "The historical verification scope is recorded, but absence of all notices and the current version status have not been verified.", "missingness": "Family-specific verification logs, relevant notices/versions and impact materials", "uncertainty": "The materials/verification still needed are as follows: Family-specific verification logs, relevant notices/versions and impact materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Family-specific correction/retraction check logs, publisher/PMC notices, DOI and cutoff date/version" }, { "item_id": "N34", "question_type": "Eligible harm denominators", "question": "Were harms and discontinuations collected for the same single-ingredient product and population?", "needed": "Eligible exposed people/people with events, event counts, duration, AE/SAE definitions/collection, dropout/discontinuation and comparator groups", "role": "Supplementary; required for a safety question", "role_reason": "Needed to avoid turning efficacy-data gaps or general safety descriptions into 0 events/incidence for the same exposure.", "application_exception": "Do not delete indirect efficacy reports because harms are unverified. Distinguish event counts, people and overlap across periods.", "criterion": "Record unverified eligible harm denominators and the lack of AE/SAE/discontinuation information in related families.", "basis": "E10: M19 §19.1.2–19.2.4; local application / H01: M19 §19.1.2–19.2.4; detailed distinctions are locally designed / H02: Design-specific harm questions in M19 §19.2; details of temporal relationships are locally designed / H03: M19 §19.2.2–19.2.4, M03 §3.2.3; local application / H04: M19 §19.1.2–19.2.4; local application / H06: M19 §19.1.2–19.2.4, M04 §4.6.3; local application. Reason for application in this case: Needed to avoid turning efficacy-data gaps or general safety descriptions into 0 events/incidence for the same exposure. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare event collection methods, duration and denominators/reasons for discontinuation for the same population/exposure to verify the scope for interpreting frequency.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Harm denominators for the same single-ingredient ordinary thiamine in trained adults are unverified. AE/SAE and discontinuations in related families are also mostly unverified, and S05's general statement is not a group/period-specific count. Records without counts of people with events, event counts and exposure duration are not converted into 0 events or incidence.", "condition_status": "Unverified", "status_reason": "Systematic collection, comparison, time/denominator and discontinuation materials for the selected same exposure/population are absent.", "missingness": "Eligible exposure, event definitions/collection, denominator/time, comparison and discontinuation materials", "uncertainty": "The materials/verification still needed are as follows: Eligible exposure, event definitions/collection, denominator/time, comparison and discontinuation materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible exposed people/people with events, event counts, duration, AE/SAE definitions/collection, dropout/discontinuation and comparator groups" }, { "item_id": "N35", "question_type": "S05 harm description", "question": "Does S05's statement of no adverse effects mean 0 events per group?", "needed": "Combination-product AE/SAE/discontinuation definitions, collection, people/event counts by group/period, exposure and tests", "role": "Supplementary", "role_reason": "Needed to avoid turning a general statement of no adverse effects or routine test results into a complete event count or safety certification.", "application_exception": "Observations of a combination in non-athletes are not incidence for an eligible single-ingredient product. Normal blood tests do not mean absence of all harms.", "criterion": "Preserve the general statement in Discussion/Table 3 together with not_reported_as_arm_period_counts.", "basis": "E10: M19 §19.1.2–19.2.4; local application / H01: M19 §19.1.2–19.2.4; detailed distinctions are locally designed / H04: M19 §19.1.2–19.2.4; local application / H06: M19 §19.1.2–19.2.4, M04 §4.6.3; local application / H09: Chamgap's own interpretive boundaries. Informed by M19 principles; not execution of an official causality tool. Reason for application in this case: Needed to avoid turning a general statement of no adverse effects or routine test results into a complete event count or safety certification. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare original collection methods, period-specific events/discontinuations and test tables to distinguish actual counts from the scope of descriptions.", "current_reports": [ "S05" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S05's general statement of no adverse effects and routine-test context are recorded, but AE is not a value reported as group/period-specific event counts. SAE and discontinuation counts are unverified. These are not transferred to 0 events or the safety/incidence of ordinary thiamine alone in trained adults.", "condition_status": "Partly verified", "status_reason": "A general statement exists, but event collection/denominators, period-specific counts and discontinuation materials are not verified.", "missingness": "S05 harm collection, group/period-specific events/denominators and discontinuation materials", "uncertainty": "The materials/verification still needed are as follows: S05 harm collection, group/period-specific events/denominators and discontinuation materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Combination-product AE/SAE/discontinuation definitions, collection, people/event counts by group/period, exposure and tests" }, { "item_id": "N36", "question_type": "Official product safety", "question": "Is S09's oral hydrochloride product document a safety result from an athlete trial?", "needed": "Thiamine HCl 100 mg product SmPC version/jurisdiction, applicable precautions/adverse reactions, populations/excipients", "role": "Supplementary", "role_reason": "Needed to avoid extending an official product's list of harms to incidence in a specific trial or personal safety for all salts/products.", "application_exception": "Injection-related reactions are not transferred to oral incidence. Precautions concerning children/pregnancy and excipients are not turned into universal contraindications for all thiamine.", "criterion": "Limit the specific UK 100 mg oral product and its 2025-02-18 revision/PL43461/0038 record to their respective context.", "basis": "C05: M03 §3.2.2–3.2.3; reverse-direction labeling and test adaptations are locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / E10: M19 §19.1.2–19.2.4; local application / H05: Design considerations in M19 §19.2.2–19.2.4; detailed confounding records are locally designed / H09: Chamgap's own interpretive boundaries. Informed by M19 principles; not execution of an official causality tool. Reason for application in this case: Needed to avoid extending an official product's list of harms to incidence in a specific trial or personal safety for all salts/products. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the applicable populations, excipients, harms and conditions of use of the same product/version, and record differences from the trial exposure.", "current_reports": [ "S09" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S09 is the UK SmPC for Thiamine HCl 100 mg tablets, recording a text revision of 2025-02-18 and PL43461/0038. GI/hypersensitivity reactions and product-specific precautions are official safety background, not verification of the same product or incidence in an athlete trial. Injection/excipient/special-population context is not extended to personal safety for all oral ordinary thiamine.", "condition_status": "Met", "status_reason": "Meets the record criterion of preserving the boundaries between official safety background for a specific product/version and trial/personal safety. This is not current reading of the full official text.", "missingness": "Actual applicable populations, excipients and harm records for the relevant product/version", "uncertainty": "The materials/verification still needed are as follows: Actual applicable populations, excipients and harm records for the relevant product/version. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Thiamine HCl 100 mg product SmPC version/jurisdiction, applicable precautions/adverse reactions, populations/excipients" }, { "item_id": "N37", "question_type": "NIH safety background", "question": "Does the absence of an established upper limit mean unlimited high-dose safety?", "needed": "Version/scope of NIH official safety/interaction and at-risk-population descriptions, and evidence for the same exposure", "role": "Supplementary", "role_reason": "Needed to avoid turning the absence of an established UL or nutritional explanations into unlimited high-dose safety or personal dosing instructions.", "application_exception": "Efficacy descriptions for other diseases are not reassessed in this performance question. Official guidance does not substitute for 0 events per group in an eligible trial.", "criterion": "Separate the historical NIH risk/interaction descriptions and limitations of the absence of an established UL from current external reading.", "basis": "C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / E10: M19 §19.1.2–19.2.4; local application / H08: M19 §19.1.2–19.2.4; local application / H09: Chamgap's own interpretive boundaries. Informed by M19 principles; not execution of an official causality tool. Reason for application in this case: Needed to avoid turning the absence of an established UL or nutritional explanations into unlimited high-dose safety or personal dosing instructions. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the scope of risks/interactions in the official version with population/exposure matching, and define necessary harm questions separately.", "current_reports": [ "S08" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S08 contains the historical risk, interaction and at-risk-population descriptions from the NIH ODS official thiamine guidance. Absence of an established upper limit does not mean unlimited high-dose safety, 0 events in an eligible trial or personal dosing instructions. Efficacy descriptions for other diseases are not reassessed as this performance effect.", "condition_status": "Met", "status_reason": "Meets the record criterion of separating official general safety background from a single performance trial/personal safety. This is not current verification of the full official text.", "missingness": "The latest official version/risk and interaction information, and harm materials for the same exposure", "uncertainty": "The materials/verification still needed are as follows: The latest official version/risk and interaction information, and harm materials for the same exposure. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Version/scope of NIH official safety/interaction and at-risk-population descriptions, and evidence for the same exposure" }, { "item_id": "N38", "question_type": "NICE limited access", "question": "Within what scope was the official refeeding excerpt used?", "needed": "The official original text/version of CG32 recommendation 1.4, high-risk refeeding population/professional context and actual access level", "role": "Supplementary", "role_reason": "Needed to avoid promoting an official search excerpt into full-text reading or direct verification of athlete dosing or deficiency treatment regimens.", "application_exception": "The two historical direct-URL failures are historical records. They do not constitute Inaccessible status in this review, and no dosing regimen is extracted/recommended.", "criterion": "Retain official_search_excerpt_only and the boundary of high-risk refeeding requiring skilled professionals.", "basis": "C03: Data collection/selection principles in M04 §4.5–4.6; separation of access from reading and the hyperlink contract are locally designed / C04: M03 §3.2.1; detailed population criteria are locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / H08: M19 §19.1.2–19.2.4; local application / H09: Chamgap's own interpretive boundaries. Informed by M19 principles; not execution of an official causality tool. Reason for application in this case: Needed to avoid promoting an official search excerpt into full-text reading or direct verification of athlete dosing or deficiency treatment regimens. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the relevant section, population and professional requirements of the official recommendation with the actual access scope.", "current_reports": [ "S10" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "S10 records verification only of the historical official search excerpt from NICE CG32 recommendation 1.4 stating that high-risk refeeding requires skilled professionals. The two direct-URL access failures and the absence of dosing-regimen extraction/recommendation are preserved. This is not turned into full-text reading or athlete dosing instructions, and no external access was attempted in this review.", "condition_status": "Partly verified", "status_reason": "The scope of the official excerpt is recorded, but the full recommendation and current version were not cross-checked.", "missingness": "The official original text/version and applicable population of the relevant CG32 section", "uncertainty": "The materials/verification still needed are as follows: The official original text/version and applicable population of the relevant CG32 section. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The official original text/version of CG32 recommendation 1.4, high-risk refeeding population/professional context and actual access level" }, { "item_id": "N39", "question_type": "Extensions and personal application", "question": "Do short-term related materials answer questions about optimal dose, long-term safety and other populations?", "needed": "Evidence for direct dose comparisons, long-term/post-discontinuation follow-up, special populations/deficiency, interactions and applicability questions", "role": "Supplementary; required for extended claims", "role_reason": "Needed to avoid establishing optimal supplementation dose, persistence of effects, personal safety or separate regulatory compliance from indirect short-term results.", "application_exception": "Do not impose every long-term/rare-event study as a requirement for the narrow TT question. Anti-doping/product regulatory judgments are separate from performance effects, and current regulations are not checked in this review.", "criterion": "Separate the selected TT from deficiency treatment, general safety/dose, long-term/personal application and other performance questions.", "basis": "E08: M03 §3.2.1–3.2.4; details of dose, persistence and effect modification are locally designed / E09: M03 §3.2.4; locally defined boundaries for extensions / H08: M19 §19.1.2–19.2.4; local application / H09: Chamgap's own interpretive boundaries. Informed by M19 principles; not execution of an official causality tool. Reason for application in this case: Needed to avoid establishing optimal supplementation dose, persistence of effects, personal safety or separate regulatory compliance from indirect short-term results. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Fix the population, exposure and duration of a separate extended question, and review suitable direct-comparison/long-term observational designs and applicability limitations.", "current_reports": [ "S08", "S09", "S10" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "This table is limited to the selected TT completion-time question. Deficiency treatment, optimal dose, long-term persistence/safety, special populations/personal dosing and anti-doping/product regulatory compliance are separate questions. Related short-term derivative, combination or general safety materials do not establish their answers.", "condition_status": "Not applicable", "status_reason": "Establishing extended effects, personal application or regulatory compliance is outside the judgment scope of the current narrow TT table. This does not certify absence of evidence for those questions.", "missingness": "Direct/long-term and applicability materials suited to a separately authorized extended question", "uncertainty": "The materials/verification still needed are as follows: Direct/long-term and applicability materials suited to a separately authorized extended question. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Evidence for direct dose comparisons, long-term/post-discontinuation follow-up, special populations/deficiency, interactions and applicability questions" }, { "item_id": "N40", "question_type": "Historical verdict and calculations", "question": "Were the original ?/null and historical calculation failures/drafts used as a new status?", "needed": "Original axes/verdict, score, stage, calculation/verification limitations and draft revision history", "role": "Required", "role_reason": "Needed to avoid reusing the original score/draft or document quality as the new table's proportion of criteria met or efficacy/safety judgment.", "application_exception": "The stage-zero calculation's null-handling error and initial B suggestion are historical records; no new calculation or grade change is made. Self-review assigning document quality A is not independent clinical certification.", "criterion": "Preserve ?/score null, Caution, unscored downstream axes and null direct results unchanged.", "basis": "C01: Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are locally designed / C07: M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design. Reason for application in this case: Needed to avoid reusing the original score/draft or document quality as the new table's proportion of criteria met or efficacy/safety judgment. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Compare the original verdict and calculation/draft/final history to distinguish the roles of criterion status and clinical grade.", "current_reports": [], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Preserve the original verdict ?, score null, Caution and unscored stage-zero downstream axes. The historical native calculator's null-handling error and pre-validation B suggestion are not an adopted new verdict. Document quality A and single-author self-checking are not used as clinical certification or a new criterion score.", "condition_status": "Met", "status_reason": "Meets the criterion of separating historical verdicts/drafts/calculations from the current table's record status. No new clinical judgment/calculation was performed.", "missingness": "Separate historical files for the original calculation/draft and final revisions (not read in this review)", "uncertainty": "The materials/verification still needed are as follows: Separate historical files for the original calculation/draft and final revisions (not read in this review). This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original axes/verdict, score, stage, calculation/verification limitations and draft revision history" }, { "item_id": "N41", "question_type": "Identity and package", "question": "Are the previous publication/package and creation of this new table distinguished as events?", "needed": "Current ID, canonical URL, duplicate proposal, package SHA and actual event materials for previous publication/deployment", "role": "Supplementary", "role_reason": "Needed to avoid inheriting previous site publication or a package hash as publication of the new table or verification of an original-paper binary.", "application_exception": "A duplicate candidate is not a confirmed permanent identity, and the original package SHA does not substitute for individual external-paper hashes. The old ZIP was not read in this review.", "criterion": "Preserve the current 3119/canonical record, candidate_not_permanent identity gaps and historical publication, and indicate that the new table has not been deployed.", "basis": "C01: Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are locally designed / C02: Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is a local application / C03: Data collection/selection principles in M04 §4.5–4.6; separation of access from reading and the hyperlink contract are locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design. Reason for application in this case: Needed to avoid inheriting previous site publication or a package hash as publication of the new table or verification of an original-paper binary. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Link the actual receipts for identity/assignment, package and publication events separately to cross-check timing and file scope.", "current_reports": [], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Preserve current ID 3119, canonical URLs and the previous 2026-09-16 publication/deployment records. The actual identity in the duplicate-key proposal remains incomplete. The original package SHA is not the binary hash of an individual original paper, and the old ZIP/separate receipts were not read in this review. This table has not been published on the website.", "condition_status": "Partly verified", "status_reason": "Current identity and historical metadata have been preserved, but full cross-checking of separate package/publication events and duplicate identity is incomplete.", "missingness": "Actual identity/package/publication receipts and duplicate-eligibility materials", "uncertainty": "The materials/verification still needed are as follows: Actual identity/package/publication receipts and duplicate-eligibility materials. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Current ID, canonical URL, duplicate proposal, package SHA and actual event materials for previous publication/deployment" }, { "item_id": "N42", "question_type": "Cutoff date and updates", "question": "Have the evidence cutoff date and this conversion review date been distinguished?", "needed": "2026-09-16 original search strategies/results, access/registration/correction logs and the current conversion review scope", "role": "Required", "role_reason": "Needed to avoid retroactively treating historical search/access as a current exhaustive search or proof of absence of studies.", "application_exception": "The separate search/web_queries.json, native_search_log and access_log were not read in this review. Reference paths alone are not grounds for claiming that the actual logs were read.", "criterion": "Separate the original evidence cutoff date 2026-09-16, this review date 2026-10-05 and the actual scope of stored-summary reading.", "basis": "C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design / C08: M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is locally designed / E06: M08 Table 8.2.a, M04 §4.6.3; local application. Reason for application in this case: Needed to avoid retroactively treating historical search/access as a current exhaustive search or proof of absence of studies. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "In an authorized subsequent update, cross-check search sources, strategies, dates, results/access and versions, and record change events.", "current_reports": [], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "The original evidence cutoff and review date are 2026-09-16. The 2026-10-05 date of this review is the date of reviewing the retained stored summaries for conversion into a table. Separate search/access-log paths in the manuscript are preserved, but the actual logs were not read in this review, and no new search or verification of original texts/registrations/latest correction status was performed.", "condition_status": "Partly verified", "status_reason": "Original date/verification-scope records exist, but separate logs and the entire current literature/versions were not newly cross-checked.", "missingness": "Original search/access, registration/correction logs and an explicit update scope", "uncertainty": "The materials/verification still needed are as follows: Original search/access, registration/correction logs and an explicit update scope. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "2026-09-16 original search strategies/results, access/registration/correction logs and the current conversion review scope" }, { "item_id": "N43", "question_type": "Current summary reading", "question": "Are actual stored-summary reading and historical external full-text access separated?", "needed": "Original source bytes, exact pointers/literals, current/historical reading by material type and actual method copies/SHA", "role": "Required", "role_reason": "Needed to avoid labeling historical abstracts, full-text copies, visual checking of some PDF pages and search excerpts/failures as full-text reading in this review.", "application_exception": "Distinguish the relevant sections of S04's original-paper reproduction from search snippets of related papers. full_text_stored=false/hash null is separate from historical HTML access records. Method copies do not mean new full-text reading.", "criterion": "Link only the actual current reading of the stored source summary, and leave all external material types as access not attempted, not acquired and not read in the current review.", "basis": "C03: Data collection/selection principles in M04 §4.5–4.6; separation of access from reading and the hyperlink contract are locally designed / C09: M04 §4.5, §4.6.3; limits of the current material conversion follow the user-defined scope and local design. Reason for application in this case: Needed to avoid labeling historical abstracts, full-text copies, visual checking of some PDF pages and search excerpts/failures as full-text reading in this review. This is not new reading of complete method texts, execution of official RoB 2/GRADE/causality tools, or certification of minimum clinical criteria.", "condition_origin": "Individually authored criteria developed after reading the currently retained 3119 content and the actual family definitions. This is a known development case, not a blinded exercise or clinical preregistration.", "proposed_research": "Cross-check input bytes, original locations, actual actions by material type and method copies to verify the scope of reading labels.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06", "S07", "S08", "S09", "S10", "S11" ], "existence": "Limited to the relevant observations, sources and stated unverified scope in the currently retained stored summaries.", "acquired_read": "Summary read: the actual locations/values in the specified retained stored summaries were read. External material types were not accessed, acquired or read in this review; access was not attempted.", "observation": "Actual reading in this review comprises the complete KO of the currently stored manuscript, structured evidence/families, bibliography, assessment/gaps and historical metadata. All external material types had no access attempt and were not acquired or read in this review. Historical access to relevant sections of S04's original-paper reproduction, S05 HTML, visual checking of some S07 PDF pages, official guidance/excerpts, failures and null retained binary hashes are distinguished. The 5 method documents represent historical reuse of actual copies/SHA from 1585 and the principles recorded at that time.", "condition_status": "Met", "status_reason": "Meets the criterion of recording the separation of current summaries/exact locations from historical external/method access. This does not mean that complete external original texts were verified in this review.", "missingness": "Actual acquisition/reading of external materials and method review within a separately authorized scope", "uncertainty": "The materials/verification still needed are as follows: Actual acquisition/reading of external materials and method review within a separately authorized scope. This limitation is confined to the current inputs and the historical verification scope; it does not mean absence of studies, an effect of 0, established safety or an external access failure in this review.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original source bytes, exact pointers/literals, current/historical reading by material type and actual method copies/SHA" } ], "reports": [ { "report_id": "S01", "title": "Webster (1998). Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives", "url": "https://pubmed.ncbi.nlm.nih.gov/9650731/", "report_type": "PubMed/publisher abstracts and subscription preview (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F01", "independent_replication": false, "observed_result": "Record at retention: an allithiamin+pantothenic-acid-related combination in highly trained cyclists. After 50 km, the 2,000 m TT values were placebo 178.2(8.4) seconds/combination 170.7(10.2) seconds, P=0.58, reported participating n=6; central-tendency/parenthetical dispersion, paired CI/analysis flow are unverified. The historical −7.5 seconds of descriptive arithmetic is not an effect of thiamine alone.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Original PubMed abstract/bibliographic record", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S01-M1", "url": "https://pubmed.ncbi.nlm.nih.gov/9650731/", "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9650731/" }, { "material_type": "Publisher abstract/original-text page", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S01-M2", "url": "https://link.springer.com/article/10.1007/s004210050364", "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9650731/" }, { "material_type": "Publisher article PDF (direct URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S01-M3", "url": null, "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9650731/" } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/9650731/" } ] }, { "report_id": "S02", "title": "Webster et al. (1997). The effect of a thiamin derivative on exercise performance", "url": "https://link.springer.com/article/10.1007/s004210050198", "report_type": "Publisher abstract and subscription preview/PubMed empty response (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F02", "independent_replication": false, "observed_result": "Record at retention: TTFD 1 g/day, 4 days per period and a 10-day washout; route/training qualifications are unverified. In the day 4, 2,000 m TT, placebo was 204.5(5.5) seconds/TTFD 200.9(4.3) seconds, P=0.61, reported participating n=14. It is distinguished from the day 3 exhaustion test, and central-tendency/dispersion types and paired CI/analysis flow remain unverified.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Publisher abstract/original-text page", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S02-M1", "url": "https://link.springer.com/article/10.1007/s004210050198", "parent_url": "https://link.springer.com/article/10.1007/s004210050198" }, { "material_type": "Original PubMed abstract/bibliographic record", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S02-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/9202948/", "parent_url": "https://link.springer.com/article/10.1007/s004210050198" }, { "material_type": "Publisher article PDF (direct URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S02-M3", "url": null, "parent_url": "https://link.springer.com/article/10.1007/s004210050198" } ], "links": [ { "label": "Source", "url": "https://link.springer.com/article/10.1007/s004210050198" } ] }, { "report_id": "S03", "title": "Suzuki and Itokawa (1996). Effects of thiamine supplementation on exercise-induced fatigue", "url": "https://link.springer.com/article/10.1007/BF02080935", "report_type": "Publisher abstract/keywords (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F03", "independent_replication": false, "observed_result": "Record at retention: the keywords are fursultiamine/TTFD, and the full-text product/route are unverified. These are fatigue/metabolic data for 16 male athlete volunteers, 100 mg/day for 3 days. The authors' classification using blood levels of 40 ng/mL is not a universal diagnostic criterion for deficiency, and the favorable fatigue/metabolic description is not a direct fixed-distance TT effect.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Publisher's original abstract/keywords and original-text page", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S03-M1", "url": "https://link.springer.com/article/10.1007/BF02080935", "parent_url": "https://link.springer.com/article/10.1007/BF02080935" }, { "material_type": "Article full text/PDF (separate direct URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S03-M2", "url": null, "parent_url": "https://link.springer.com/article/10.1007/BF02080935" } ], "links": [ { "label": "Source", "url": "https://link.springer.com/article/10.1007/BF02080935" } ] }, { "report_id": "S04", "title": "Choi et al. (2013). The effects of endurance training and thiamine supplementation on anti-fatigue during exercise", "url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise", "report_type": "Relevant methods sections of the original-paper reproduction (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F04", "independent_replication": false, "observed_result": "Record at retention: crossover data for oral TTFD, placebo and training in 9 women with athletic/Taekwondo experience. Exercise at 70% VO2max and 50 rpm for a fixed 60 minutes is not TT completion time. The ambiguity in total/per-administration dose in the record of 10 mg/kg, three administrations, 30 minutes after meals/150 mL water and 4 weeks is not resolved by conversion. Relevant sections of the original-paper reproduction on ResearchGate are distinguished from snippets of related papers and PMC/old-PDF access limitations.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "ResearchGate original-paper reproduction/copy page and relevant sections", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S04-M1", "url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise", "parent_url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise" }, { "material_type": "PMC original-paper HTML", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S04-M2", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4241913/", "parent_url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise" }, { "material_type": "Full article in a historical PDF repository", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S04-M3", "url": "https://www.e-sciencecentral.org/upload/jenb/pdf/jenb-17-4-189.pdf", "parent_url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise" } ], "links": [ { "label": "Source", "url": "https://www.researchgate.net/publication/270656791_The_effects_of_endurance_training_and_thiamine_supplementation_on_anti-fatigue_during_exercise" } ] }, { "report_id": "S05", "title": "Lee et al. (2023). A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/", "report_type": "PMC original-paper HTML (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F05", "independent_replication": false, "observed_result": "Record at retention: non-athlete crossover data for the Ex PLUS combination, with 32 unique participants and initial sequences of 16/16. There were 28 days per period and a 14-day washout; time to exhaustion was 12.56±SD 1.9 minutes/15.82±SD 1.91 minutes, P<0.0001, with longer being better. This is not relabeled as a TT of B1 alone or as 64 people. Paired CI, period/carryover effects and AE counts by group/period are unverified; company/public funding, supply/blinding assistance and the declaration are preserved together.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "PMC original-paper HTML", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S05-M1", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/", "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/" }, { "material_type": "Relevant sections of original results in Figure 4/Table 3", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S05-M2", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/", "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/" }, { "material_type": "Separate SAP/complete period-specific results (existence/URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S05-M3", "url": null, "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/" } ], "links": [ { "label": "Source", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10542023/" } ] }, { "report_id": "S06", "title": "Bautista-Hernández et al. (2008). Effect of Thiamine Pyrophosphate on Levels of Serum Lactate, Maximum Oxygen Consumption and Heart Rate in Athletes Performing Aerobic Activity", "url": "https://journals.sagepub.com/doi/10.1177/147323000803600608", "report_type": "Publisher abstract/references (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F06", "independent_replication": false, "observed_result": "Record at retention: data for 27 reported male athlete participants receiving TPP 1 mg/kg. Administration schedule/route and analysis flow are unverified, and route is not inferred from the 0.9% saline control. Favorable lactate, VO2max and heart-rate descriptions are not a fixed-distance TT effect of oral ordinary thiamine.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Publisher's original abstract/references and original-text page", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S06-M1", "url": "https://journals.sagepub.com/doi/10.1177/147323000803600608", "parent_url": "https://journals.sagepub.com/doi/10.1177/147323000803600608" }, { "material_type": "Article PDF (direct URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S06-M2", "url": null, "parent_url": "https://journals.sagepub.com/doi/10.1177/147323000803600608" } ], "links": [ { "label": "Source", "url": "https://journals.sagepub.com/doi/10.1177/147323000803600608" } ] }, { "report_id": "S07", "title": "Masuda et al. (2015). Effect of thiamin (vitamin B1) on carbohydrate metabolism at rest and during exercise", "url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_article", "report_type": "Review HTML/PDF and visual checking of some pages (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": null, "independent_replication": false, "observed_result": "Record at retention: a review of thiamine and carbohydrate metabolism, with pp.337–341 and visual checking of some pages, 339/341, recorded historically. Simple citation reuse under B1 does not erase differences in original derivatives, combinations/endpoints. The original study_id is null, and it is not counted as a new trial, person or direct replication.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Review full-text HTML", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S07-M1", "url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_article", "parent_url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_article" }, { "material_type": "Review article PDF", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S07-M2", "url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_pdf/-char/en", "parent_url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_article" } ], "links": [ { "label": "Source", "url": "https://www.jstage.jst.go.jp/article/jpfsm/4/4/4_337/_article" } ] }, { "report_id": "S08", "title": "NIH Office of Dietary Supplements. Thiamin: Health Professional Fact Sheet", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/", "report_type": "NIH ODS official health-professional HTML (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": null, "independent_replication": false, "observed_result": "Record at retention: historical risk, interaction and at-risk-population descriptions in NIH official guidance. Absence of an established UL does not mean unlimited high-dose safety or personal dosing instructions, nor 0 events per group in an eligible trial. Sections on efficacy for other diseases are not reassessed in this performance question.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Full NIH ODS official health-professional webpage", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S08-M1", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/", "parent_url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/" } ], "links": [ { "label": "Source", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/" } ] }, { "report_id": "S09", "title": "Flamingo Pharma UK Ltd. Thiamine Hydrochloride 100 mg Tablets: Summary of Product Characteristics", "url": "https://www.medicines.org.uk/emc/product/13528/smpc", "report_type": "SmPC HTML for a specific UK oral product (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": null, "independent_replication": false, "observed_result": "Record at retention: the SmPC for Flamingo Pharma UK's Thiamine HCl 100 mg tablets. Preserve the §4.2–4.8/7–10, 2025-02-18 text-revision and PL43461/0038 records and product-specific GI/hypersensitivity context. This is not an athlete trial product/incidence, and injection, children/pregnancy/excipient precautions are not extended to all oral thiamine.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "UK official SmPC HTML for the relevant product", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S09-M1", "url": "https://www.medicines.org.uk/emc/product/13528/smpc", "parent_url": "https://www.medicines.org.uk/emc/product/13528/smpc" } ], "links": [ { "label": "Source", "url": "https://www.medicines.org.uk/emc/product/13528/smpc" } ] }, { "report_id": "S10", "title": "NICE CG32. Nutrition support for adults", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations", "report_type": "NICE official search excerpt and direct-URL failures (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": null, "independent_replication": false, "observed_result": "Record at retention: verification of the context of high-risk refeeding requiring skilled professionals solely from an official search excerpt of CG32 recommendation 1.4. Preserve the two direct-URL failures and the absence of dosing-regimen extraction/recommendation. This is not promoted to an access failure/full-text reading in this review or to athlete dosing instructions.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Full NICE CG32 official recommendation HTML", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S10-M1", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations", "parent_url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" }, { "material_type": "Historical official search excerpt (separate URL unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S10-M2", "url": null, "parent_url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" } ], "links": [ { "label": "Source", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" } ] }, { "report_id": "S11", "title": "ClinicalTrials.gov NCT05586295", "url": "https://clinicaltrials.gov/study/NCT05586295", "report_type": "ClinicalTrials.gov 11-line shell (historical access)", "existence": "Limited to source identities and historical records/unverified scope in the currently stored summaries. Current external versions/public availability were not looked up.", "acquired_read": "Summary read: only the relevant actual locations in the currently stored manuscript were read. External material types were not read in this review.", "study_family": "F05", "independent_replication": false, "observed_result": "Record at retention: NCT05586295's historical 11-line shell record. The number and S05's 09/12/2022 are preserved, but first submission/study start, prospective registration and endpoint hierarchy/version history are unverified. The registration link for the same F05 is not a new result or independent trial.", "result_level": "The historical extraction/access in the 2026-09-16 stored source summary is converted into the current presentation. This is not new external verification, clinical calculation or reassessment.", "source_evidence_date": "2026-09-16", "materials": [ { "material_type": "Complete official registry record", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S11-M1", "url": "https://clinicaltrials.gov/study/NCT05586295", "parent_url": "https://clinicaltrials.gov/study/NCT05586295" }, { "material_type": "Official registry change history/initial version (content unverified)", "public_status": "Unverified (no external lookup in this review)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Separate historical material types/partial access from current summary reading.", "material_id": "S11-M2", "url": "https://clinicaltrials.gov/study/NCT05586295", "parent_url": "https://clinicaltrials.gov/study/NCT05586295" } ], "links": [ { "label": "Source", "url": "https://clinicaltrials.gov/study/NCT05586295" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility criteria and reasons for changes, and distinguish variations in the intervention.", "review_level": "Historical reuse of actual method HTML copies/SHA from 1585 and the principles recorded at that time. This is not new reading of complete method texts or official implementation/certification." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish and link studies and reports, and do not omit a study solely because its outcomes are not reported.", "review_level": "Historical reuse of actual method HTML copies/SHA from 1585 and the principles recorded at that time. This is not new reading of complete method texts or official implementation/certification." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Hold the outcome and effect of interest fixed, then assess randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Historical reuse of actual method HTML copies/SHA from 1585 and the principles recorded at that time. This is not new reading of complete method texts or official implementation/certification." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Historical reuse of actual method HTML copies/SHA from 1585 and the principles recorded at that time. This is not new reading of complete method texts or official implementation/certification." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Questions about harms may require designs, populations and follow-up different from efficacy questions. Case reports do not establish incidence.", "review_level": "Historical reuse of actual method HTML copies/SHA from 1585 and the principles recorded at that time. This is not new reading of complete method texts or official implementation/certification." } ], "status_dictionary": { "Met": "Meeting narrow record criteria, such as identity, exclusion/attribution, original verdicts, and current versus historical reading. This is not verification of clinical efficacy/safety or complete external texts.", "Partly verified": "Some actual retained reports exist, but verification of original methods, denominators/dispersion, implementation, plans/access remains outstanding.", "Unverified": "The required values/materials cannot be established from the current inputs and the historical verification scope. Distinguish unverified information in the materials from actual review still outstanding.", "Not reported": "Limited to non-reporting in specific materials/sections actually read; not extended to complete external texts that have not been read.", "Conflicting information": "Used only when incompatible records of the same fact have actually been verified. S04's dose ambiguity and differences between trials/formulations/endpoints are not turned into newly confirmed conflicts.", "Inaccessible": "Used only when actual external access has failed in this review. External access was not attempted and external materials were not read in this review; historical failures are not inherited.", "Review incomplete": "Means external materials have not been cross-checked in this review or actual work remains outstanding. Unverified information in materials already reviewed within the limited scope is not labeled as failure of the entire review.", "Not applicable": "Not applicable to establishing long-term outcomes/optimal dose, personal application or regulatory compliance outside the narrow TT question. This is not certification of absence of studies, no effect or safety for those questions." }, "study_overlap": { "state": "These are report links for the stored related materials. F01 (S01): Webster1998_derivative_combination · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · allithiamin derivative, not ordinary thiamine; coadministration of pantethine/pantothenic acid; no isolated-thiamine contrast / F02 (S02): Webster1997_TTFD · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · TTFD derivative, not ordinary thiamine; operational trained-adult qualification not verified / F03 (S03): Suzuki1996_exercise_fatigue · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · no standardized time-trial completion result verified; TTFD/fursultiamine keyword; do not treat unspecified thiamine title as ordinary salt / F04 (S04): Choi2013_TTFD_training · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · TTFD derivative; fixed-duration 60-minute exercise with biochemical/RPE measurements, not completion-time trial / F05 (S05, S11): Lee2023_ExPLUS · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · multicomponent supplement; explicit non-athlete population; time-to-exhaustion, not completion time / F06 (S06): Bautista2008_TPP · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · thiamine pyrophosphate is not the allowed ordinary base/HCl/mononitrate entity; no standardized time-trial completion result; oral route not verified. Whether F01 and F02 are the same cohort is unverified. Shared authors do not establish identity or independence, and no pooled n is created. The original study_id null is retained for S07 review, S08 NIH, S09 product and S10 NICE. S11 registration links to F05 and is not a new clinical family/replication. The overall number of unique trials and total number of participants are unverified. Reports, bibliographic entries and family labels are not added up as independent replications or an overall trial count.", "unique_trial_count": null, "unique_participant_count": null, "reason": "These are report links for the stored related materials. F01 (S01): Webster1998_derivative_combination · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · allithiamin derivative, not ordinary thiamine; coadministration of pantethine/pantothenic acid; no isolated-thiamine contrast / F02 (S02): Webster1997_TTFD · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · TTFD derivative, not ordinary thiamine; operational trained-adult qualification not verified / F03 (S03): Suzuki1996_exercise_fatigue · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · no standardized time-trial completion result verified; TTFD/fursultiamine keyword; do not treat unspecified thiamine title as ordinary salt / F04 (S04): Choi2013_TTFD_training · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · TTFD derivative; fixed-duration 60-minute exercise with biochemical/RPE measurements, not completion-time trial / F05 (S05, S11): Lee2023_ExPLUS · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · multicomponent supplement; explicit non-athlete population; time-to-exhaustion, not completion time / F06 (S06): Bautista2008_TPP · Original report and its PubMed/publisher/reproduction entries count as one family. Review citations are not additional trials. · thiamine pyrophosphate is not the allowed ordinary base/HCl/mononitrate entity; no standardized time-trial completion result; oral route not verified. Whether F01 and F02 are the same cohort is unverified. Shared authors do not establish identity or independence, and no pooled n is created. The original study_id null is retained for S07 review, S08 NIH, S09 product and S10 NICE. S11 registration links to F05 and is not a new clinical family/replication. The overall number of unique trials and total number of participants are unverified. Reports, bibliographic entries and family labels are not added up as independent replications or an overall trial count." }, "history": [ { "date": "2026-11-06", "kind": "Separation of public-facing display and data", "view_version": "1.0", "change": "The public-facing display and data were created from the existing 43 items. No new clinical search, change in verification status or scoring was performed." } ], "language": "en", "translation_date": "2026-11-06" }