{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3117-main", "verdict_number": "3117", "title": "Ordinary thiamine (vitamin B1) × Handgrip improvement in objectively weak adults", "view_version": "1.0", "view_created_date": "2026-11-06", "criteria_version": "3117-ORAL-THIAMINE-HANDGRIP-1.0", "criteria_date": "2026-10-05", "review_date": "2026-10-05", "legacy_evidence_date": "2026-09-16", "review_scope": { "materials_read": "Stored Korean and English manuscripts and case-specific criteria and application records", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "No external clinical abstracts, full texts, registrations or analysis plans were newly read. Reading the stored summaries is distinguished from not having read the external original materials, and the original assessment, numerical values and unverified information are preserved. No new searches, calculations or reassessments were performed.", "date_meaning": "This is the date the stored materials were checked, not the date of an up-to-date clinical literature search." }, "claim_context": { "population": "Adults with objectively verified reduced muscle strength; actual cutoff and thiamine status unverified", "intervention": "Single-ingredient oral preparation; thiamine base/hydrochloride/nitrate kept separate, selected salt unverified", "dose": "Eligible-study dose unverified", "comparator": "Placebo, no added thiamine, or usual care with all other treatments matched", "endpoint": "A single handgrip endpoint; hand, device, repeated-measurement rules, units, and principal time point unverified", "duration": "Eligible-study treatment duration unverified", "excluded_extensions": "Do not combine fatigue, muscle mass, walking, neurological symptoms/deficiency correction, injections/derivatives/combinations, dietary associations, or separate functional/event outcomes into a direct handgrip effect." }, "requirements": [ { "item_id": "N01", "question_type": "Independent claim", "question": "Which population, route, and strength outcome does this table address?", "needed": "Current independent claim, adults with objectively reduced muscle strength, oral ordinary thiamine, comparator, and handgrip boundary", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid combining fatigue, muscle mass, walking, and deficiency treatment with comparative handgrip efficacy.", "application_exception": "Do not arbitrarily fill in the salt, dose, test, or time point from adjacent studies to resolve the absence of a verified selected trial.", "criterion": "Maintain the same unit of inquiry as the original question and distinguish question-level boundaries from actual trial identity.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify comparative handgrip data that meet this boundary, and assess other endpoints and formulations as separate questions.", "current_reports": [], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The current claim is a single comparative handgrip question about single-ingredient oral ordinary thiamine in adults with objectively reduced muscle strength. The source explicitly specifies a single independent claim, and no actual trial has been fixed. The original stored summary has no subclaims key.", "condition_status": "Met", "status_reason": "This verifies preservation of the claim boundary. It does not mean that a directly eligible trial or effect has been verified.", "missingness": "This verifies preservation of the claim boundary. It does not mean that a directly eligible trial or effect has been verified.", "uncertainty": "This verifies preservation of the claim boundary. It does not mean that a directly eligible trial or effect has been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Current independent claim, adults with objectively reduced muscle strength, oral ordinary thiamine, comparator, and handgrip boundary" }, { "item_id": "N02", "question_type": "Ingredient, salt, and product", "question": "Have the ordinary-thiamine salt and single-ingredient product in the target trial been verified?", "needed": "Base/hydrochloride/nitrate, manufacturer, ingredients/excipients, and free-thiamine-equivalent amount of the product in an eligible original report", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid identifying the actual trial product from derivatives, a separate licensed product, or mixed CMT treatments.", "application_exception": "Specifying single-ingredient ordinary thiamine in the question is different from verifying the actual product.", "criterion": "Retain null values for the actual salt/product and the exclusion of derivatives and combination products separately.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare product and ingredient records from an eligible trial, and extract derivative/combination exposures separately.", "current_reports": [ "S05", "S06", "S11", "S15" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The question concerns single-ingredient ordinary thiamine, but no eligible study has been selected, so the actual salt and product are unverified. The actual_salt field in the assessment question's identity is null. It was not filled using the mixture of CMT hydrochloride and derivative exposures or the separate 100 mg product in S15.", "condition_status": "Unverified", "status_reason": "The eligible product and actual chemical form cannot be identified within the current retained scope.", "missingness": "The eligible product and actual chemical form cannot be identified within the current retained scope.", "uncertainty": "The eligible product and actual chemical form cannot be identified within the current retained scope.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Base/hydrochloride/nitrate, manufacturer, ingredients/excipients, and free-thiamine-equivalent amount of the product in an eligible original report" }, { "item_id": "N03", "question_type": "Route and physical dosage form", "question": "Have the question's oral route and the actual tablet/capsule form been distinguished?", "needed": "Oral route, physical dosage form, and manufacturing/batch data for an eligible comparison", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid transferring responses from injection cases or a specific tablet's product information to the target trial exposure.", "application_exception": "Preserve the oral-route boundary of the question without automatically assigning an unverified tablet/capsule form.", "criterion": "Explain the oral question, exclusion of injections, and the gap concerning the actual physical dosage form.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify administration and physical dosage form in the original trial, and link injection and derivative evidence separately.", "current_reports": [ "S09", "S15" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The claim's route is oral, and injections are not allowed. The physical dosage form of an actually eligible product is unverified. The intramuscular 100 mg, 2 times per week cases in S09 and the tablets in S15 were not used as the oral product in the target handgrip trial.", "condition_status": "Partly verified", "status_reason": "The route boundary is clear, but the actual eligible product and physical dosage form have not been verified.", "missingness": "The route boundary is clear, but the actual eligible product and physical dosage form have not been verified.", "uncertainty": "The route boundary is clear, but the actual eligible product and physical dosage form have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Oral route, physical dosage form, and manufacturing/batch data for an eligible comparison" }, { "item_id": "N04", "question_type": "Nominal and actual dose", "question": "Have the dose and adherence in the target handgrip trial been verified?", "needed": "Nominal dose, dosing schedule, active amount, actual adherence/exposure, and concomitant supplementation by eligible group", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning 10 mg, 600–1800 mg, or high-dose case reports into effective doses for this population.", "application_exception": "Doses in adjacent studies are historical records, not individual dosing recommendations or dose-response evidence.", "criterion": "Distinguish the null value for the actual target dose from historical doses in individual sources.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link dosing/adherence records for an eligible product to outcome denominators, and assess direct dose comparisons separately.", "current_reports": [ "S01", "S03" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The actual_dose and verified_values.dose fields for an eligible handgrip comparison are null. Wilkinson's 10 mg/day and TARIF's 600–1800 mg/day are historical exposures in different populations/outcomes. No dose conversion, calculation, or dosing suggestion was made in this work.", "condition_status": "Unverified", "status_reason": "Actual dose, schedule, adherence, and handgrip outcomes by dose for the target comparison are unverified.", "missingness": "Actual dose, schedule, adherence, and handgrip outcomes by dose for the target comparison are unverified.", "uncertainty": "Actual dose, schedule, adherence, and handgrip outcomes by dose for the target comparison are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Nominal dose, dosing schedule, active amount, actual adherence/exposure, and concomitant supplementation by eligible group" }, { "item_id": "N05", "question_type": "Duration and principal time point", "question": "Have the eligible treatment duration and handgrip measurement time point been verified?", "needed": "Eligible treatment duration, principal handgrip time point, follow-up after discontinuation, and measurements by visit", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid filling in 3 months, 4 weeks, 5 days, or long-term cases as verified timing for the target question.", "application_exception": "Do not replace the question's unverified duration with the duration of an adjacent trial.", "criterion": "Preserve null actual_duration/actual_timepoint values separately from durations in individual sources.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify visit, treatment, and discontinuation times in an eligible comparison, and assess maintenance effects using separate data.", "current_reports": [ "S01", "S03", "S12" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The treatment duration and principal handgrip time point of a selected eligible trial are null. Wilkinson's 3 months, TARIF's 4-week periods and washout, and allithiamine's 5 days were not combined as target efficacy over the same period.", "condition_status": "Unverified", "status_reason": "The appropriate duration, principal time point, and sustained effect for the target handgrip comparison have not yet been verified.", "missingness": "The appropriate duration, principal time point, and sustained effect for the target handgrip comparison have not yet been verified.", "uncertainty": "The appropriate duration, principal time point, and sustained effect for the target handgrip comparison have not yet been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible treatment duration, principal handgrip time point, follow-up after discontinuation, and measurements by visit" }, { "item_id": "N06", "question_type": "Population and reduced strength", "question": "Is there an actual enrollment cutoff for objectively reduced muscle strength?", "needed": "Adult inclusion/exclusion, definition of objectively reduced handgrip, cutoff, baseline distribution, and verified subgroup", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning low TPP, older age, fatigue, or a low group mean into reduced muscle strength in every participant.", "application_exception": "Distinguish the question's population definition from verification of an actually eligible population.", "criterion": "Leave the cutoff unverified and explain mismatches in adjacent populations with reference to the original source locations.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Obtain enrollment criteria, individual/subgroup baseline handgrip, and prespecified definitions before comparing population eligibility.", "current_reports": [ "S01", "S03", "S12" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The target is adults with objectively reduced muscle strength, but actual_weakness_cutpoint is null. Older adults with low TPP in TF01, IBD patients with fatigue in TF02, and healthy students do not automatically meet that definition.", "condition_status": "Unverified", "status_reason": "The eligible reduced-strength cutoff, baseline distribution, and selected subgroup are unverified.", "missingness": "The eligible reduced-strength cutoff, baseline distribution, and selected subgroup are unverified.", "uncertainty": "The eligible reduced-strength cutoff, baseline distribution, and selected subgroup are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Adult inclusion/exclusion, definition of objectively reduced handgrip, cutoff, baseline distribution, and verified subgroup" }, { "item_id": "N07", "question_type": "Nutritional status and deficiency", "question": "Can deficiency correction be separated from the effect of general additional supplementation?", "needed": "Thiamine status, deficiency definition, handgrip outcomes by status, and deficiency-treatment context in an eligible population", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid transferring low TPP, deficiency neuropathy, or altered nutritional requirements to the efficacy of general strength supplementation.", "application_exception": "This undetermined assessment is not an instruction to stop necessary deficiency treatment.", "criterion": "Keep actual_thiamine_status null and identify deficiency correction as a separate question.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare status definitions, treatment context, and direct handgrip comparisons by status separately.", "current_reports": [ "S01", "S16", "S17" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Thiamine status in an actually eligible population is null. Selection for low erythrocyte TPP and objectively reduced muscle strength are different criteria, and deficiency correction or refeeding management does not replace evidence of efficacy for general handgrip supplementation.", "condition_status": "Unverified", "status_reason": "Nutritional status and effects by deficient/nondeficient status in the target comparison have not been verified.", "missingness": "Nutritional status and effects by deficient/nondeficient status in the target comparison have not been verified.", "uncertainty": "Nutritional status and effects by deficient/nondeficient status in the target comparison have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Thiamine status, deficiency definition, handgrip outcomes by status, and deficiency-treatment context in an eligible population" }, { "item_id": "N08", "question_type": "Comparison and background care", "question": "Have the actual comparator and balance of concomitant treatments been verified?", "needed": "Eligible placebo/no added thiamine/matched usual care, concomitant treatments, changes/rescue treatment, and adherence", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning other CMT treatments or healthy-participant biomarker comparisons into handgrip comparators.", "application_exception": "Distinguish the intended comparator from the null actual_comparator value, without requiring every change in every group to be identical.", "criterion": "Record the question's comparison separately from the actual unverified comparator and effects of concomitant interventions.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link background care and changes by group to the analysis of the actual effect of interest.", "current_reports": [ "S05", "S06", "S07" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The question's comparators are placebo, no added thiamine, or usual care with all other treatments matched. The actually eligible comparator is null. Mixed CMT formulations/other treatments and healthy-participant biomarker comparisons are not matched untreated long-term handgrip comparators.", "condition_status": "Unverified", "status_reason": "Group-specific concomitant-treatment and exposure data needed to distinguish the eligible comparison and the selected thiamine's contribution are unverified.", "missingness": "Group-specific concomitant-treatment and exposure data needed to distinguish the eligible comparison and the selected thiamine's contribution are unverified.", "uncertainty": "Group-specific concomitant-treatment and exposure data needed to distinguish the eligible comparison and the selected thiamine's contribution are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible placebo/no added thiamine/matched usual care, concomitant treatments, changes/rescue treatment, and adherence" }, { "item_id": "N09", "question_type": "Handgrip measurement", "question": "Is there an actual target measurement specifying hand, device, units, and repeated-measurement rules?", "needed": "Eligible handgrip device/calibration, hand, posture, repetition/aggregation rules, units, assessor masking, and principal time point", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid filling in dominant-hand measurement with a Preston device as the protocol of an unselected target trial.", "application_exception": "The name of an objective measurement alone does not resolve measurement bias or its importance for daily function.", "criterion": "Distinguish null actual device/hand/unit values from test information in adjacent studies.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Extract eligible testing procedures and implementation/assessment by group together with the original handgrip results.", "current_reports": [ "S01" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "For the target handgrip outcome, actual_device, actual_hand, actual_units, and the principal time point are null. Dominant-hand Preston measurement in TF01 is adjacent-trial information and does not automatically establish repeated-measurement rules or the target protocol.", "condition_status": "Unverified", "status_reason": "Actual measurement, aggregation, group-specific assessment conditions, and units for the target handgrip outcome are unverified.", "missingness": "Actual measurement, aggregation, group-specific assessment conditions, and units for the target handgrip outcome are unverified.", "uncertainty": "Actual measurement, aggregation, group-specific assessment conditions, and units for the target handgrip outcome are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible handgrip device/calibration, hand, posture, repetition/aggregation rules, units, assessor masking, and principal time point" }, { "item_id": "N10", "question_type": "Endpoint hierarchy", "question": "Have the page's handgrip question and the original trial's primary endpoint been distinguished?", "needed": "Handgrip endpoint, principal time point/analysis hierarchy in eligible registration/planning records, and actual reporting", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning a primary fatigue endpoint and a secondary handgrip excerpt into the same prespecified primary handgrip effect.", "application_exception": "The fact that handgrip is the page's target does not itself mean that it was the trial's primary endpoint or was preregistered.", "criterion": "Distinguish handgrip being fixed at the question level from the unverified actual trial hierarchy and plan.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare registration, protocol, and analysis plan with actual handgrip reporting.", "current_reports": [ "S03", "S18" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The question-level endpoint is fixed as handgrip. No directly eligible trial has been selected, and the actual prespecified endpoint hierarchy is unverified. TARIF remains in the context of primary fatigue and an excerpt concerning secondary handgrip.", "condition_status": "Partly verified", "status_reason": "The page's endpoint is clear, but comparison of eligible prespecified hierarchy with reporting is incomplete.", "missingness": "The page's endpoint is clear, but comparison of eligible prespecified hierarchy with reporting is incomplete.", "uncertainty": "The page's endpoint is clear, but comparison of eligible prespecified hierarchy with reporting is incomplete.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Handgrip endpoint, principal time point/analysis hierarchy in eligible registration/planning records, and actual reporting" }, { "item_id": "N11", "question_type": "TF01 enrollment", "question": "Are the 76 older adults with low TPP an objectively weak population?", "needed": "Wilkinson enrollment criteria, TPP strata, baseline low-handgrip cutoff/prespecified subgroup", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid promoting the closest controlled trial to a direct trial matching the target population.", "application_exception": "Low TPP and a low group mean alone do not establish reduced strength in every person or subgroup.", "criterion": "Retain the trial of 76 participants together with the reasons for the population mismatch.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify original enrollment, baseline handgrip, and prespecified comparisons by stratum to prepare material for reassessing eligibility.", "current_reports": [ "S01", "S02" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Wilkinson is a placebo-controlled study of 10 mg/day for 3 months in 76 older adults. The entry criterion was erythrocyte TPP <140 nmol/L, not an objective reduced-strength cutoff. It was therefore not selected as directly eligible for the current target efficacy question.", "condition_status": "Partly verified", "status_reason": "The trial exists, but a direct comparison in an objectively weak population or prespecified stratum has not been verified.", "missingness": "The trial exists, but a direct comparison in an objectively weak population or prespecified stratum has not been verified.", "uncertainty": "The trial exists, but a direct comparison in an objectively weak population or prespecified stratum has not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Wilkinson enrollment criteria, TPP strata, baseline low-handgrip cutoff/prespecified subgroup" }, { "item_id": "N12", "question_type": "TF01 testing and timing", "question": "Has the scope of dominant-hand Preston grip measurement and 3 months of exposure been preserved?", "needed": "S01 testing, units/repetitions, time points, original results tables, and quantitative handgrip contrast", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid assigning the device/time to another trial or claiming new verification of the complete testing section.", "application_exception": "Historical access to a full-text reproduction on a 3rd-party host differs from reading the local summary in this work.", "criterion": "Attribute dominant-hand Preston measurement/10 mg/3 months to TF01 and retain the additional measurement gaps.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify testing procedures and analysis values in the original Methods/Results/tables, and link them to the same outcome.", "current_reports": [ "S01" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained TF01 record describes dominant-hand grip with a Preston dynamometer and oral 10 mg/day for 3 months. S01 was an HTML reproduction of the original report on a 3rd-party host at that time, with recorded layout errors in text extraction from the two-column article. The original clinical full text was not reread in this work.", "condition_status": "Partly verified", "status_reason": "Testing and duration information is retained, but the quantitative contrast, applicability of units/repetition procedures to the target, and current comparison with the original text are unverified.", "missingness": "Testing and duration information is retained, but the quantitative contrast, applicability of units/repetition procedures to the target, and current comparison with the original text are unverified.", "uncertainty": "Testing and duration information is retained, but the quantitative contrast, applicability of units/repetition procedures to the target, and current comparison with the original text are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S01 testing, units/repetitions, time points, original results tables, and quantitative handgrip contrast" }, { "item_id": "N13", "question_type": "TF01 allocation and masking", "question": "Does a randomized/double-blind label establish actual implementation?", "needed": "S01 allocation/concealment, who was masked/masking success, baseline balance, actual adherence, and analysis handling", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid erasing concealment, deviation, measurement, or selective-reporting problems on the basis of the design's name.", "application_exception": "Do not borrow methods from an indirect trial to assign the bias axis of an eligible trial.", "criterion": "Distinguish the reported parallel design/TPP stratification from unverified implementation details.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare the original methods with baseline, implementation, and analysis information for the handgrip outcome of interest.", "current_reports": [ "S01" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "TF01 is recorded as a randomized double-blind placebo-controlled parallel trial stratified by pretreatment TPP status. The current input is not independent verification of actual concealment, masking success, or adherence by group.", "condition_status": "Partly verified", "status_reason": "The design is reported, but information is insufficient to establish actual implementation/adherence or outcome-specific bias.", "missingness": "The design is reported, but information is insufficient to establish actual implementation/adherence or outcome-specific bias.", "uncertainty": "The design is reported, but information is insufficient to establish actual implementation/adherence or outcome-specific bias.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "S01 allocation/concealment, who was masked/masking success, baseline balance, actual adherence, and analysis handling" }, { "item_id": "N14", "question_type": "TF01 denominators", "question": "Are 38 versus 38 and completion by all being turned into a handgrip analysis denominator?", "needed": "Allocation/completion, handgrip measurement and analysis denominators, missingness, and variance/intervals", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid assuming from participation/completion counts alone that all handgrip observations and analyses involve the same numbers.", "application_exception": "Retain the existing record of 76, 38/38, and completion by all without creating new sums.", "criterion": "Distinguish original participation/completion records from unverified handgrip analyses and effect intervals.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link measurement/analysis counts at each time point in the original handgrip tables with missing-data handling and variance definitions.", "current_reports": [ "S01" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained TF01 evidence records 76 participants, 38 thiamine/38 placebo, and completion by all. These were not automatically used as the analysis count for the target eligible population or the number of handgrip observations at every time point. The eligible handgrip effect/CI are null.", "condition_status": "Partly verified", "status_reason": "The verification levels of participation/completion information and handgrip-specific analysis denominators/intervals differ.", "missingness": "The verification levels of participation/completion information and handgrip-specific analysis denominators/intervals differ.", "uncertainty": "The verification levels of participation/completion information and handgrip-specific analysis denominators/intervals differ.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Allocation/completion, handgrip measurement and analysis denominators, missingness, and variance/intervals" }, { "item_id": "N15", "question_type": "TF01 nonsignificance and estimation", "question": "Is handgrip nonsignificance being read as an effect of 0 or equivalence?", "needed": "Original handgrip treatment contrast, variance, CI, exact P, and analysis population/model", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning a statement about significance into a quantitative effect magnitude or exclusion of benefit.", "application_exception": "The statement that a quantitative contrast was not reported is limited to the retained extraction currently read.", "criterion": "Preserve the nonsignificant report together with unverified numerical values/intervals, and do not make new calculations.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If the original between-group handgrip estimate/interval and analysis definition are acquired, compare them separately from clinical importance.", "current_reports": [ "S01" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained Wilkinson record states that handgrip did not change significantly, but provides no quantitative treatment contrast, CI, or exact P. The historical extraction stating that Table 3 lacks a handgrip-change contrast is preserved, and no conclusion of no effect or equivalence was made.", "condition_status": "Partly verified", "status_reason": "There is a statement of nonsignificance, but magnitude, precision, and exclusion of a meaningful benefit have not been verified.", "missingness": "There is a statement of nonsignificance, but magnitude, precision, and exclusion of a meaningful benefit have not been verified.", "uncertainty": "There is a statement of nonsignificance, but magnitude, precision, and exclusion of a meaningful benefit have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original handgrip treatment contrast, variance, CI, exact P, and analysis population/model" }, { "item_id": "N16", "question_type": "Funding and provision", "question": "Is funding from indirect trials being borrowed as independent efficacy replication?", "needed": "TF01/TF02/TF03 funding, product provision, author declarations/patents, and family relationships", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning the names of public/private funders into absence of product provision or conflicts of interest, or into independent replication.", "application_exception": "Do not automatically exclude a study because funding exists or establish bias because it is unknown.", "criterion": "Distinguish retained funding and not-reported/unverified provision information from the currently unscored independence axis.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare original Funding/COI, product provision, and family relationships by outcome.", "current_reports": [ "S01", "S04", "S05" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "TF01 funding was from Canterbury Medical Research Foundation and Sanitarium Health Food Company; product provision was not reported. TF02 records Danish foundations, and TF03 records Russian foundation/State Task support; product provision is unverified. These were not borrowed to assign the independence axis for directly eligible evidence.", "condition_status": "Partly verified", "status_reason": "Funding is reported, but complete product/author conflict-of-interest information and eligible independent replication have not been verified.", "missingness": "Funding is reported, but complete product/author conflict-of-interest information and eligible independent replication have not been verified.", "uncertainty": "Funding is reported, but complete product/author conflict-of-interest information and eligible independent replication have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "TF01/TF02/TF03 funding, product provision, author declarations/patents, and family relationships" }, { "item_id": "N17", "question_type": "TF02 population and endpoint", "question": "Is a handgrip excerpt from an IBD-fatigue crossover trial the target result?", "needed": "TARIF baseline reduced-strength enrollment/strata, handgrip analysis results, and fatigue/handgrip hierarchy", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning severe chronic fatigue and a secondary handgrip excerpt into a direct effect in an objectively weak population.", "application_exception": "Do not modify existing fatigue verdict 3086 or borrow it to score handgrip efficacy.", "criterion": "Separate the existence of the 40-participant fatigue trial from gaps concerning the target population and quantitative handgrip results.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare original handgrip subgroups, results, and denominators with the prespecified plan to reassess eligibility.", "current_reports": [ "S03", "S04" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "TARIF is a 40-participant trial in quiescent IBD with severe chronic fatigue, with fatigue as the primary endpoint. An objectively weak enrollment population or prespecified low-strength treatment stratum was not verified, and handgrip nonsignificance is in the context of an indexed excerpt. Existing fatigue verdict 3086 was not changed.", "condition_status": "Partly verified", "status_reason": "Related human research exists, but population eligibility and handgrip values/denominators have not been verified.", "missingness": "Related human research exists, but population eligibility and handgrip values/denominators have not been verified.", "uncertainty": "Related human research exists, but population eligibility and handgrip values/denominators have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "TARIF baseline reduced-strength enrollment/strata, handgrip analysis results, and fatigue/handgrip hierarchy" }, { "item_id": "N18", "question_type": "TF02 crossover and analysis", "question": "Are the 40 participants across two periods being counted as independent participants or a between-group handgrip effect?", "needed": "4-week treatment, 4-week washout, sequence/period, paired data, handgrip analysis counts, and carryover/model", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid summing crossover participants as new people in each period or borrowing fatigue analysis as handgrip analysis.", "application_exception": "Do not create an eligible crossover estimand while population/endpoint mismatches remain unresolved.", "criterion": "Distinguish the retained schedule and nominal dose from unverified handgrip-specific analysis.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify sequence, period, paired variance, handling of carryover, and actual denominators in the original crossover handgrip analysis.", "current_reports": [ "S03", "S04" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained TARIF record describes a 40-participant crossover trial comparing 600–1800 mg/day in 4-week periods separated by a 4-week washout. Handgrip analysis denominators, quantitative effect/CI, paired data, and carryover handling were not verified. Participants were not combined as independent people/trials across the two periods.", "condition_status": "Partly verified", "status_reason": "The crossover schedule is available, but the target handgrip estimand, denominator, model, and precision are unverified.", "missingness": "The crossover schedule is available, but the target handgrip estimand, denominator, model, and precision are unverified.", "uncertainty": "The crossover schedule is available, but the target handgrip estimand, denominator, model, and precision are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "4-week treatment, 4-week washout, sequence/period, paired data, handgrip analysis counts, and carryover/model" }, { "item_id": "N19", "question_type": "TF02 registration", "question": "Have the NCT identifier and actual reading of the plan/amendment history been distinguished?", "needed": "Structured content of NCT03634735, original registration timing, handgrip hierarchy/analysis, and amendment history", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid turning a registration number into prospective registration or completion of selective-reporting assessment.", "application_exception": "Distinguish historical shell/API/DNS failures from external access not attempted in this work.", "criterion": "Preserve verification of the identifier and unverified content/history, without newly assigning a current Inaccessible status.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "In an authorized update, compare the official registration/history with the handgrip plan in the original report.", "current_reports": [ "S18" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "NCT03634735 is an identifier verified in the original report. At that time, an official page shell, web API error, and native API DNS failure prevented verification of the content; prospective registration timing was also not independently verified. No new registration lookup was performed in this work.", "condition_status": "Partly verified", "status_reason": "The number is available, but comparison of the actual plan, handgrip hierarchy, amendments, and prospective timing is unverified.", "missingness": "The number is available, but comparison of the actual plan, handgrip hierarchy, amendments, and prospective timing is unverified.", "uncertainty": "The number is available, but comparison of the actual plan, handgrip hierarchy, amendments, and prospective timing is unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Structured content of NCT03634735, original registration timing, handgrip hierarchy/analysis, and amendment history" }, { "item_id": "N20", "question_type": "TF02 subsequent reports", "question": "Is the supplied 3086 extraction being read as new full-text reading or independent replication?", "needed": "Original identities of subsequent metabolic/maintenance reports, common family/population, and handgrip endpoint/access", "role": "Required (selected handgrip question)", "role_reason": "This is needed to avoid counting the hydrochloride lead in previously supplied material and subsequent fatigue analyses as new handgrip trials.", "application_exception": "Do not record that older protected_input files or external subsequent full texts were opened in this work.", "criterion": "Distinguish the historical supplied-material/multiple-report role of S19 from unverified handgrip results.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify the original identity, cohort, and handgrip data in each subsequent report, and link it to the same family.", "current_reports": [ "S19" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S19 is a lead from the previously supplied 3086 snapshot concerning the TARIF metabolic analysis and PMID34592862 maintenance follow-up. It is a historical record reusing the same family and oral HCl identity context, not new original full-text reading, fatigue reassessment, or handgrip replication in this work.", "condition_status": "Partly verified", "status_reason": "A supplied record exists, but report-specific handgrip results/eligibility and current comparison with original texts are unverified.", "missingness": "A supplied record exists, but report-specific handgrip results/eligibility and current comparison with original texts are unverified.", "uncertainty": "A supplied record exists, but report-specific handgrip results/eligibility and current comparison with original texts are unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original identities of subsequent metabolic/maintenance reports, common family/population, and handgrip endpoint/access" }, { "item_id": "N21", "question_type": "TF03 composition and denominators", "question": "Are the 15, 14, 5, and 2 participants counted as the same trial of a pure oral preparation in adults?", "needed": "Age, formulation, other treatments, and participants/denominators for handgrip follow-up in each row of the CMT supplementary material", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid combining mixed formulations, a participant aged 16, other treatments, and different denominators into a single oral-treatment result in adults.", "application_exception": "The existing denominators are historical extractions; no additional totals or effect calculations are generated in this work.", "criterion": "Preserve the supplementary material's 15 participants/14 adults, 5 adult HCl rows, and 2 participants with long-term HCl handgrip observations according to their respective roles.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link age, formulation, and follow-up results from the original Table S1/figures to individual rows.", "current_reports": [ "S05", "S06", "S07" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained CMT supplementary material records 14 adults among 15 participants, 5 adult hydrochloride rows, and 2 participants identified in the long-term hydrochloride handgrip figure. A patient aged 16, derivatives, and other treatments are mixed in. These denominators were not used as a single randomized oral-treatment comparison in adults or as a total of independent participants.", "condition_status": "Partly verified", "status_reason": "The mixed composition is recorded, but there is no matched control or between-group handgrip estimate for a pure oral preparation in adults.", "missingness": "The mixed composition is recorded, but there is no matched control or between-group handgrip estimate for a pure oral preparation in adults.", "uncertainty": "The mixed composition is recorded, but there is no matched control or between-group handgrip estimate for a pure oral preparation in adults.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Age, formulation, other treatments, and participants/denominators for handgrip follow-up in each row of the CMT supplementary material" }, { "item_id": "N22", "question_type": "TF03 handgrip figure", "question": "Were HCl in patients 1 and 3 distinguished from sulbutiamine in patient 2?", "needed": "Patient-specific formulations, durations, handgrip follow-up, concomitant treatments/controls, and original measurements in Figure 1", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid converting favorable before-and-after observations into a causal between-group effect of ordinary thiamine.", "application_exception": "The Russian/English reports concern the same cohort/translation and are not independent replications.", "criterion": "Preserve individual formulations and uncontrolled follow-up without repurposing them as comparative efficacy evidence.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Compare each patient's handgrip follow-up with actual exposure/concomitant treatment, and obtain comparison data under the same conditions separately.", "current_reports": [ "S05", "S06", "S07" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "In the retained Figure 1 description, patients 1 and 3 received thiamine HCl, and patient 2 received sulbutiamine. The Russian/English reports and supplementary material belong to the same family. Before-and-after handgrip observations were not converted into a causal between-group effect, and derivatives were not pooled with ordinary thiamine.", "condition_status": "Partly verified", "status_reason": "Patients/formulations were distinguished, but a matched comparator and quantitative between-group handgrip effect remain unverified.", "missingness": "Patients/formulations were distinguished, but a matched comparator and quantitative between-group handgrip effect remain unverified.", "uncertainty": "Patients/formulations were distinguished, but a matched comparator and quantitative between-group handgrip effect remain unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Patient-specific formulations, durations, handgrip follow-up, concomitant treatments/controls, and original measurements in Figure 1" }, { "item_id": "N23", "question_type": "TF03 biomarkers and controls", "question": "Is a healthy-person biomarker comparison an untreated handgrip control?", "needed": "Actual comparators, tests, and time points for the biomarker comparison/Figure S2 and long-term handgrip observations", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid importing healthy controls for different outcomes/time points into the same handgrip efficacy comparison.", "application_exception": "Distinguish the historical record of visual review of 3 supplementary PDF pages from the current reading of the summary.", "criterion": "Record the comparative meaning of biomarkers and handgrip, and the unverified control, separately.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Check the original materials for an actual control with the same handgrip measurement, time point, and exposure.", "current_reports": [ "S05", "S06" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The currently retained record does not treat the healthy metabolic comparison group as an untreated long-term handgrip control. Figure S2 contains biomarker data, not a handgrip treatment contrast. The visual review of 3 supplementary PDF pages for S06 is a historical access record.", "condition_status": "Met", "status_reason": "This verifies the boundary preventing repurposing of other outcomes/controls. It does not establish acquisition of an eligible handgrip comparison.", "missingness": "This verifies the boundary preventing repurposing of other outcomes/controls. It does not establish acquisition of an eligible handgrip comparison.", "uncertainty": "This verifies the boundary preventing repurposing of other outcomes/controls. It does not establish acquisition of an eligible handgrip comparison.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Actual comparators, tests, and time points for the biomarker comparison/Figure S2 and long-term handgrip observations" }, { "item_id": "N24", "question_type": "TF03 correction", "question": "Were the existence of a correction and verification of its actual full text distinguished?", "needed": "Original/corrected versions, page changes, scope of text/table corrections, and effects on attribution of handgrip observations", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid treating a bibliographic correction, inaccessible full text, or search excerpt as a fully verified clinical correction.", "application_exception": "Do not count a correction within the same family as a new trial or use the gray-shading excerpt as a verified fact.", "criterion": "Preserve the historical correction notice, page correction, unacquired full text, and excerpt limitations.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "During a permitted update, compare the complete correction with the original table and review linked observations/statuses.", "current_reports": [ "S08" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S08 records the existence of a formal correction, but its full text was inaccessible at the time. Distinguish the original publisher's page-range correction of 1–22→1161–1182 from the search excerpt about gray shading in Table3. The excerpt was not promoted to verified correction text, and no new correction lookup was performed in this work.", "condition_status": "Partly verified", "status_reason": "The existence/bibliographic record of a correction and its actual impact on clinical text have different levels of verification.", "missingness": "The existence/bibliographic record of a correction and its actual impact on clinical text have different levels of verification.", "uncertainty": "The existence/bibliographic record of a correction and its actual impact on clinical text have different levels of verification.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original/corrected versions, page changes, scope of text/table corrections, and effects on attribution of handgrip observations" }, { "item_id": "N25", "question_type": "TF04 injection cases", "question": "Are the two DM1 cases being read as an oral-treatment handgrip comparison?", "needed": "Actual route, 100 mg 2 times per week, symptoms/measurements, and presence or absence of a control in the DM1 cases", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid transferring uncontrolled improvement with intramuscular injections to an effect of single-ingredient oral treatment on handgrip.", "application_exception": "Preserve the existence of the cases rather than recasting it as an absence of human research; distinguish only their eligibility for the target question.", "criterion": "Indicate the 2 cases, injection route, uncontrolled design, and current non-reading of the external full text.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Preserve the exposures/measurements in the original cases and review the target oral-treatment handgrip comparison using separate materials.", "current_reports": [ "S09" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The two DM1 cases in S09 involved intramuscular thiamine 100 mg 2 times per week, not a controlled oral-treatment dynamometer trial. The historical full_text_HTML access record was not reused as a claim of current full-text reading.", "condition_status": "Met", "status_reason": "This is a retained classification verifying differences in route/design, not verification of target efficacy.", "missingness": "This is a retained classification verifying differences in route/design, not verification of target efficacy.", "uncertainty": "This is a retained classification verifying differences in route/design, not verification of target efficacy.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Actual route, 100 mg 2 times per week, symptoms/measurements, and presence or absence of a control in the DM1 cases" }, { "item_id": "N26", "question_type": "TF05 general health", "question": "Is well-being in healthy older women being transferred to a handgrip effect in people with low muscle strength?", "needed": "Smidt's baseline definition of low muscle strength, handgrip results, health/well-being endpoints, and denominators", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid treating older age, marginal thiamine status, and improved well-being as the same handgrip outcome in objectively weak participants.", "application_exception": "Preserve the existence of the original trial in healthy participants without newly importing an effect size.", "criterion": "Distinguish the context of 80 participants/10 mg/6 weeks and a 4-week baseline from gaps in the target population/endpoint.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If original eligibility criteria/handgrip measurements are available, compare them with the conditions of the same question.", "current_reports": [ "S10" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The retained S10 record concerns 80 healthy older women, 10 mg/day, and 6 weeks of double-blind treatment following a 4-week baseline. Selection for low muscle strength and a separate objective muscle-strength contrast were not verified, and well-being results were not borrowed as a handgrip benefit.", "condition_status": "Partly verified", "status_reason": "An adjacent trial exists, but the target low-strength population/handgrip outcome remains unverified.", "missingness": "An adjacent trial exists, but the target low-strength population/handgrip outcome remains unverified.", "uncertainty": "An adjacent trial exists, but the target low-strength population/handgrip outcome remains unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Smidt's baseline definition of low muscle strength, handgrip results, health/well-being endpoints, and denominators" }, { "item_id": "N27", "question_type": "TF06 TTFD", "question": "Are the TTFD title and landing page being read as numerical evidence for ordinary thiamine?", "needed": "Original molecular identity, title/material type, and level of access to actual population/measurement results", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid pooling a derivative and an original article verified only at title level with handgrip effects of ordinary thiamine.", "application_exception": "Do not turn 'double blind' in a title into a complete extraction of methods/numbers.", "criterion": "Preserve both the molecular exclusion of TTFD and the lack of extraction of original numerical results.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link the derivative to a separate question and verify direct results for ordinary thiamine separately.", "current_reports": [ "S11" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S11 identifies a different molecule from the title/landing page of an original TTFD article. The full text was not extracted, and no numerical results are claimed. It was not pooled as direct evidence for the ordinary-thiamine question.", "condition_status": "Met", "status_reason": "This verifies the molecular/access boundary, not original effect estimates or target efficacy.", "missingness": "This verifies the molecular/access boundary, not original effect estimates or target efficacy.", "uncertainty": "This verifies the molecular/access boundary, not original effect estimates or target efficacy.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original molecular identity, title/material type, and level of access to actual population/measurement results" }, { "item_id": "N28", "question_type": "TF07 allithiamine", "question": "Is an isokinetic P>0.05 in healthy participants being read as no handgrip effect?", "needed": "Allithiamine, 15 healthy students, 5 days/1 g, Biodex isokinetic results, and original intervals", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid converting nonsignificance for a derivative, a different population, and a different muscle-strength endpoint into a target effect of 0.", "application_exception": "The existing P>0.05 is a historical report; no exact P value or equivalence interval is generated.", "criterion": "Indicate differences in molecule/population/endpoint together with the limitations of nonsignificance.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Attribute the original result to its derivative/isokinetic question and review the handgrip comparison separately.", "current_reports": [ "S12" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Doyle concerns a placebo crossover study of allithiamine 1 g/day for 5 days in 15 healthy students, with isokinetic muscle performance measured using Biodex System2. P>0.05 does not establish no effect or equivalence for ordinary thiamine, adults with low muscle strength, and handgrip.", "condition_status": "Met", "status_reason": "This verifies the boundary for a different molecule/population/endpoint. The target effect size/interval remains unverified.", "missingness": "This verifies the boundary for a different molecule/population/endpoint. The target effect size/interval remains unverified.", "uncertainty": "This verifies the boundary for a different molecule/population/endpoint. The target effect size/interval remains unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Allithiamine, 15 healthy students, 5 days/1 g, Biodex isokinetic results, and original intervals" }, { "item_id": "N29", "question_type": "TF08 functional recovery", "question": "Were FIM recovery, actual handgrip, and an oral-treatment comparison distinguished?", "needed": "FIM results, actual route/comparator, separate handgrip testing, and access to original methods", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid transferring overall function in deficiency neuropathy to an isolated handgrip outcome.", "application_exception": "Do not infer an oral preparation/comparator from inaccessible methods.", "criterion": "Retain the general functional endpoint and unverified route/methods.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If original methods/handgrip data are acquired, compare the actual route, control, and endpoint for correspondence.", "current_reports": [ "S13" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S13 contains FIM functional-limitation/recovery data. Detailed methods and route/comparator could not be verified from the historical indexed abstract excerpt and full-text 402 failure record. FIM was not converted into a separate handgrip contrast.", "condition_status": "Partly verified", "status_reason": "Adjacent functional data exist, but the identity of the target oral treatment/handgrip outcome/comparator remains unverified.", "missingness": "Adjacent functional data exist, but the identity of the target oral treatment/handgrip outcome/comparator remains unverified.", "uncertainty": "Adjacent functional data exist, but the identity of the target oral treatment/handgrip outcome/comparator remains unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "FIM results, actual route/comparator, separate handgrip testing, and access to original methods" }, { "item_id": "N30", "question_type": "Other diseases and combinations", "question": "Do PBC fatigue and B-vitamin/magnesium results replicate a single-ingredient handgrip effect?", "needed": "The disease/endpoint in S20 and the combined ingredients/fatigue question and original access in S21", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid attributing results for fatigue in another disease or for a combined intervention to ordinary thiamine alone for handgrip.", "application_exception": "Do not borrow effect sizes or rescore the existing fatigue assessment.", "criterion": "Preserve differences in disease/endpoint/ingredient eligibility for each source.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Separate actual results by question and review the single-ingredient handgrip comparison using separate materials.", "current_reports": [ "S20", "S21" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S20 is a PBC fatigue trial and is not counted as a refutation or replication for handgrip. S21 is a lead for an IBD fatigue trial of combined B1/B6/B12+magnesium, from which the handgrip efficacy of B1 alone cannot be isolated. The unverified DOI in the 2026 record and the status of the supplied composition snapshot were preserved.", "condition_status": "Met", "status_reason": "This verifies the boundary for another disease, a combination, and fatigue. It does not establish acquisition of a target handgrip comparison.", "missingness": "This verifies the boundary for another disease, a combination, and fatigue. It does not establish acquisition of a target handgrip comparison.", "uncertainty": "This verifies the boundary for another disease, a combination, and fatigue. It does not establish acquisition of a target handgrip comparison.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The disease/endpoint in S20 and the combined ingredients/fatigue question and original access in S21" }, { "item_id": "N31", "question_type": "Dietary association", "question": "Is a micronutrient association in Korean adults being recast as supplementation efficacy?", "needed": "Dietary observational design, direction of the exposure/handgrip association, and presence or absence of an actual randomized supplementation comparison", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid converting a dietary-intake association into a single-ingredient treatment or a supplementation dose/need.", "application_exception": "Do not calculate a supplementation dose from dietary intake in this work or import the original observational effect.", "criterion": "Indicate the difference between questions about observational associations and intervention comparisons.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link the dietary association to its original direction and verify a single-ingredient supplementation handgrip comparison separately.", "current_reports": [ "S23" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S23 contains dietary observational data on micronutrients and handgrip in Korean adults. It is not randomized assignment to single-ingredient oral supplementation; dietary intake was not converted into a supplementation dose, and the association was not converted into causal efficacy.", "condition_status": "Met", "status_reason": "This verifies the association/intervention boundary, not direct handgrip efficacy or a need for supplementation.", "missingness": "This verifies the association/intervention boundary, not direct handgrip efficacy or a need for supplementation.", "uncertainty": "This verifies the association/intervention boundary, not direct handgrip efficacy or a need for supplementation.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Dietary observational design, direction of the exposure/handgrip association, and presence or absence of an actual randomized supplementation comparison" }, { "item_id": "N32", "question_type": "Reports and families", "question": "How should 23 sources, 11 families, and 0 directly eligible comparisons be interpreted?", "needed": "Links from report to study/case family to endpoint/time point; provisionally related reports; duplication/unique counts", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid counting bibliographic records, registrations, safety sources, reviews, and access attempts as 23 trials, or converting 0 directly eligible comparisons into 0 human studies.", "application_exception": "Do not treat the TF01 lead for potentially shared recruitment of 222 people as a verified independent trial or an additional denominator.", "criterion": "Distinguish the current structural family/report relationships from unverified overall unique study/participant counts.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify recruitment/registration/population/result links for each report and preserve relationships identified as the same or unknown.", "current_reports": [ "S01", "S02", "S03", "S04", "S05", "S06", "S07", "S08", "S18", "S19", "S22" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The 23 current sources/citations entries are a provenance list mixing clinical reports, supplements/corrections, registrations, safety sources, reviews, and bibliographic leads. The records of 11 structural families and 0 directly eligible comparisons are preserved without interpreting them as an absence of all human research. CMT translations/supplements/corrections and TARIF follow-up reports belong to their respective existing families; the TF01 related report from 2000 remains only an unverified lead for possibly shared recruitment of 222 people.", "condition_status": "Met", "status_reason": "This verifies the retained family/duplication policy. Total unique study/participant counts from a comprehensive search have not been verified.", "missingness": "This verifies the retained family/duplication policy. Total unique study/participant counts from a comprehensive search have not been verified.", "uncertainty": "This verifies the retained family/duplication policy. Total unique study/participant counts from a comprehensive search have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Links from report to study/case family to endpoint/time point; provisionally related reports; duplication/unique counts" }, { "item_id": "N33", "question_type": "Target effect and analysis", "question": "Is an unverified effect being filled in using within-group changes or baseline handgrip?", "needed": "Eligible between-group handgrip estimand; ITT/PP/adjustment; original effect/CI/exact P; denominators", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid constructing a target causal effect from baseline values, nonsignificance, or favorable before-and-after observations in adjacent studies.", "application_exception": "Do not fill invalid raw calculation suggestions or an eligibility-schema gap with an effect of 0.", "criterion": "Keep primary_effect/CI/P null and no_effect_claim=false.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify the effect of interest, population, and between-group estimate/interval together in an eligible original analysis.", "current_reports": [ "S01", "S03", "S05" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "For eligible handgrip, primary_effect, primary_CI, and primary_p are null, and the effect direction is unknown. E0/E+ was not assigned from within-group changes, baseline handgrip, or adjacent nonsignificant findings, and no new clinical calculations were performed in this work.", "condition_status": "Unverified", "status_reason": "The eligible effect of interest, original analysis population/model, and estimate/interval remain unverified.", "missingness": "The eligible effect of interest, original analysis population/model, and estimate/interval remain unverified.", "uncertainty": "The eligible effect of interest, original analysis population/model, and estimate/interval remain unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible between-group handgrip estimand; ITT/PP/adjustment; original effect/CI/exact P; denominators" }, { "item_id": "N34", "question_type": "Precision and meaning", "question": "Does objective handgrip guarantee a benefit in daily function or clinical events?", "needed": "Eligible handgrip interval, justified important difference, meaning of the test, and separate daily-function outcomes", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid arbitrarily establishing patient-important benefit, H/P, or equivalence from objectivity, significance, or sample size.", "application_exception": "Do not assign an unsupported MCID, required participant count/duration, or P/S as new numbers/axes.", "criterion": "Distinguish unverified importance/intervals and test meaning from separate function/event questions.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Verify the original interval and a valid criterion for handgrip importance; review function/events separately using direct data.", "current_reports": [], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "An eligible between-group CI and MCID have not been verified. Objective measurement alone does not make handgrip H or P, and force measurement differs from improvement in daily function. The existing axes remain unscored; no arbitrary P/S, C1/C0/CX, or participant-count/duration criteria were assigned.", "condition_status": "Unverified", "status_reason": "Without an effect interval, its importance, and the meaning of the actual measurement, a meaningful benefit can neither be established nor ruled out.", "missingness": "Without an effect interval, its importance, and the meaning of the actual measurement, a meaningful benefit can neither be established nor ruled out.", "uncertainty": "Without an effect interval, its importance, and the meaning of the actual measurement, a meaningful benefit can neither be established nor ruled out.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible handgrip interval, justified important difference, meaning of the test, and separate daily-function outcomes" }, { "item_id": "N35", "question_type": "Plans and selective reporting", "question": "Is selective reporting being established merely because an eligible registration/plan is unavailable?", "needed": "Eligible original registration/protocol/analysis plan, endpoints/time points, reasons for changes, and corrected versions", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid converting unacquired plans into confirmed non-registration, selective reporting, or absence of original results.", "application_exception": "Do not use unverified TF01/TF03 registrations or the TARIF identifier as verification of an eligible plan.", "criterion": "Indicate the actual eligible plan that could not be compared and access limitations for adjacent materials.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "After comparing an actual eligible plan with the handgrip report, record the scope of changes/selection.", "current_reports": [ "S01", "S05", "S18" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "No directly eligible handgrip trial could be selected, so comparison with its registration/plan remains unverified. The unverified TF01 registration, the distinction between TF03 ethics approval and trial registration, and TARIF history-access limitations were preserved. These are not interpreted as confirmed selective reporting.", "condition_status": "Unverified", "status_reason": "Materials needed to verify an eligible comparison of the prespecified plan with the report and the original reasons for changes remain unverified.", "missingness": "Materials needed to verify an eligible comparison of the prespecified plan with the report and the original reasons for changes remain unverified.", "uncertainty": "Materials needed to verify an eligible comparison of the prespecified plan with the report and the original reasons for changes remain unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Eligible original registration/protocol/analysis plan, endpoints/time points, reasons for changes, and corrected versions" }, { "item_id": "N36", "question_type": "Harms of an oral product", "question": "Does a separate 100 mg SmPC provide the safety denominator for the target exposure?", "needed": "Product-specific adverse reactions/frequencies in S15; eligible actual exposure/duration and population; collection, discontinuations, and denominators", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid transferring precautions for an authorized product to individual safety or incidence in the target handgrip trial.", "application_exception": "Preserve existing cautions without deleting the efficacy manuscript because of gaps in harm information.", "criterion": "Distinguish product-specific reactions from unverified target frequencies/denominators and doses safe for long-term use.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link adverse-event collection, group-specific denominators/durations, and discontinuations for an eligible exposure to the product identity.", "current_reports": [ "S15" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "S15 records nausea, vomiting, diarrhea, abdominal pain, and hypersensitivity with unknown frequency for a specific oral thiamine hydrochloride 100 mg product. Allergy to product excipients is also separate. Harm denominators/frequencies in a target eligible trial and doses safe for long-term use in renal/hepatic impairment remain unverified.", "condition_status": "Partly verified", "status_reason": "A separate product provides harm context, but incidence and long-term safety for the target population/actual exposure have not been verified.", "missingness": "A separate product provides harm context, but incidence and long-term safety for the target population/actual exposure have not been verified.", "uncertainty": "A separate product provides harm context, but incidence and long-term safety for the target population/actual exposure have not been verified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Product-specific adverse reactions/frequencies in S15; eligible actual exposure/duration and population; collection, discontinuations, and denominators" }, { "item_id": "N37", "question_type": "Safety by route and special population", "question": "Are injection-related hypersensitivity and product-specific pregnancy/pediatric restrictions being generalized?", "needed": "Route of hypersensitivity reactions, product-specific pregnancy/lactation and age recommendations, and applicability to populations", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid turning an injection-related anaphylaxis risk rate or product restrictions into contraindications to all oral nutritional intake.", "application_exception": "Do not extend the adult handgrip question to children or pregnancy.", "criterion": "Indicate historical cautions limited to the route/product/population without claiming established safety.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link safety materials for the relevant product/route/population separately from the efficacy question.", "current_reports": [ "S15" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Reports of severe hypersensitivity were mainly observed with injections, and their risk rate is not applied to oral preparations. The S15 product is not intended for pregnancy/lactation and is not recommended below 3 years of age, but these restrictions are not generalized to contraindications to all nutritional thiamine intake. The adult handgrip question is not extended to children/pregnancy.", "condition_status": "Partly verified", "status_reason": "Route/product-specific cautions exist, but these materials do not verify population-specific safety in the target trial.", "missingness": "Route/product-specific cautions exist, but these materials do not verify population-specific safety in the target trial.", "uncertainty": "Route/product-specific cautions exist, but these materials do not verify population-specific safety in the target trial.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Route of hypersensitivity reactions, product-specific pregnancy/lactation and age recommendations, and applicability to populations" }, { "item_id": "N38", "question_type": "Interactions and medical management", "question": "Do dialysis, malabsorption, and refeeding management establish the benefit of general handgrip supplementation?", "needed": "Drug interactions, requirements in dialysis/malabsorption, and actual medical management of alcohol-related deficiency/refeeding", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid converting different requirements or combined medical management into high-dose oral handgrip efficacy or a safety upper limit.", "application_exception": "Do not assert an absence of interactions or interpret this as an instruction to stop necessary deficiency treatment.", "criterion": "Distinguish the original medical/drug context from separate gaps in efficacy/safety.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Review relevant drugs/medical situations by product/population, separately from direct target handgrip data.", "current_reports": [ "S14", "S16", "S17" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Furosemide may affect thiamine status, and fluorouracil requires separate review. Requirements in dialysis/malabsorption and medical management of alcohol-related deficiency/refeeding do not establish general high-dose oral handgrip efficacy or a safety upper limit. Combined NICE management is not used as evidence for single-ingredient efficacy.", "condition_status": "Partly verified", "status_reason": "Medical/drug caution contexts exist, but direct efficacy, the full range of interactions, and safety limits for the target exposure remain unverified.", "missingness": "Medical/drug caution contexts exist, but direct efficacy, the full range of interactions, and safety limits for the target exposure remain unverified.", "uncertainty": "Medical/drug caution contexts exist, but direct efficacy, the full range of interactions, and safety limits for the target exposure remain unverified.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Drug interactions, requirements in dialysis/malabsorption, and actual medical management of alcohol-related deficiency/refeeding" }, { "item_id": "N39", "question_type": "UL and safety limits", "question": "Are the absence of an established UL and water solubility being read as unlimited safety?", "needed": "Reason no UL was established, actual toxicity data, safety by population/dose/duration, and harm denominators", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid turning insufficient data, water solubility, or excretion into a guarantee of high-dose safety for an individual.", "application_exception": "Do not propose unsupported numerical safety limits or doses.", "criterion": "Record both the reason no limit was established and the unverified therapeutic dose/long-term safety.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If toxicity/harm data for a population/exposure are added, compare them with the original product and denominator/duration.", "current_reports": [ "S14", "S16" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Retained S16 and safety_detail state that no UL was established because toxicity data were insufficient. Water solubility and urinary excretion do not guarantee unlimited safety. The target dose safe for long-term use in renal/hepatic impairment also remains unverified, and study doses are not individual recommendations.", "condition_status": "Partly verified", "status_reason": "The reason for the absence of a UL is recorded, but this does not verify target high-dose/long-term safety.", "missingness": "The reason for the absence of a UL is recorded, but this does not verify target high-dose/long-term safety.", "uncertainty": "The reason for the absence of a UL is recorded, but this does not verify target high-dose/long-term safety.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Reason no UL was established, actual toxicity data, safety by population/dose/duration, and harm denominators" }, { "item_id": "N40", "question_type": "Separate expanded questions", "question": "Are data on optimal dose, maintenance, subgroups, and falls/mortality being imposed as mandatory for this table?", "needed": "Identity and direct evidence for the original handgrip question and separate dose, maintenance, function, and event extensions", "role": "Supplementary (required if a separate expanded claim is made)", "role_reason": "Needed to avoid requiring every extension study for a narrow, unresolved handgrip question or expanding an adjacent main effect.", "application_exception": "Do not turn unverified exposure/duration essential to the original comparative handgrip question into NA.", "criterion": "Do not impose the extensions themselves as requirements for the current question; distinguish them from actual exposure/denominator gaps.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If an expanded question is raised separately, review direct dose, follow-up, subgroup, function, and event results separately.", "current_reports": [], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The current standalone question concerns comparative handgrip efficacy, not optimal dose, persistence after discontinuation, or prevention of falls/mortality. Extension studies are not imposed as requirements for this narrow question. Unverified actual target dose, duration/principal time point, and direct handgrip effect remain recorded in earlier rows.", "condition_status": "Not applicable", "status_reason": "Requiring expanded questions is not applicable. This does not replace gaps in the original handgrip exposure/population/outcome or verify effects for expanded questions.", "missingness": "Requiring expanded questions is not applicable. This does not replace gaps in the original handgrip exposure/population/outcome or verify effects for expanded questions.", "uncertainty": "Requiring expanded questions is not applicable. This does not replace gaps in the original handgrip exposure/population/outcome or verify effects for expanded questions.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Identity and direct evidence for the original handgrip question and separate dose, maintenance, function, and event extensions" }, { "item_id": "N41", "question_type": "Scope of searches and absence claims", "question": "Is unverified eligibility in the recorded search being declared an absence of human research?", "needed": "The 2026-09-16 search/cutoff date, actual inputs/failures, and scope for unpublished studies, registrations, corrections, and retractions", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid overstating the scope of an old search and the current table conversion as an up-to-date comprehensive search.", "application_exception": "Do not label the absence of external searching in this work or unacquired full texts as 0 studies or no recent corrections.", "criterion": "Distinguish the scope of the historical search/literature map and current local reading from incomplete external verification.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "In a separately permitted update, record actual search/registration/correction results and the scope of failures/unverified information.", "current_reports": [ "S22" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The original evidence cutoff date is 2026-09-16, and the original reader-facing answer limits its statement to no directly eligible controlled result being verified in the recorded search. The S22 review serves only as a literature map/indexed excerpt and is not used for decisive numbers or scoring. No new search, correction/retraction lookup, or reading of old search/extraction files was performed in this work.", "condition_status": "Partly verified", "status_reason": "A retained search scope exists, but an up-to-date exhaustive/unpublished-study/correction check and actual comparison with old separate files were not performed.", "missingness": "A retained search scope exists, but an up-to-date exhaustive/unpublished-study/correction check and actual comparison with old separate files were not performed.", "uncertainty": "A retained search scope exists, but an up-to-date exhaustive/unpublished-study/correction check and actual comparison with old separate files were not performed.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "The 2026-09-16 search/cutoff date, actual inputs/failures, and scope for unpublished studies, registrations, corrections, and retractions" }, { "item_id": "N42", "question_type": "Original assessment and document quality", "question": "Are the original ?/null, document A, and calculator exception being read as new evidence?", "needed": "Original grade/score, unscored axes, eligibility exception, document evaluation, and reviewer identity", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid changing the original current values into a score of 0, no effect, no human research, or independent clinical certification.", "application_exception": "The invalid raw suggestion and calculator-schema problem are historical records, not a calculator run/reassessment in this work.", "criterion": "Preserve the original ?/null/Caution, document A/self-review, and human_study_exists=true.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "Link new direct evidence or a schema change to a separate event/version and judgment.", "current_reports": [], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "The original grade is ?, the score is null, the safety label is Caution, and the downstream evidence axes remain unscored. Preserve human_study_exists=true alongside unverified direct eligibility. The calculator's eligibility gap/invalid raw suggestion is an unadopted historical record; the calculator was not run in this work. Document A/ChatGPT self-review is not independent clinical review or efficacy certification.", "condition_status": "Met", "status_reason": "This verifies the distinction between the roles of original values and document/calculation metadata. It is not a new clinical judgment or score.", "missingness": "This verifies the distinction between the roles of original values and document/calculation metadata. It is not a new clinical judgment or score.", "uncertainty": "This verifies the distinction between the roles of original values and document/calculation metadata. It is not a new clinical judgment or score.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Original grade/score, unscored axes, eligibility exception, document evaluation, and reviewer identity" }, { "item_id": "N43", "question_type": "Reading and original bytes", "question": "Are summary reading and historical full-text access being shown as the same verification?", "needed": "Physical type, historical access level/location, current non-reading, and retained-summary pointer/literal/SHA for each material", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid turning local-summary reading or historical 3rd-party full-text/abstract access or registration-access failures into current reading of original clinical sources.", "application_exception": "The stored-manuscript SHA is not a hash of the original bytes of an external PDF/original article.", "criterion": "Link summaries to exact retained locations and indicate current non-attempted/non-read external access and the absence of preserved original bytes.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If new materials are permitted, link actual acquisition/reading and original bytes/versions to the relevant rows/materials.", "current_reports": [ "S01", "S06", "S09", "S14", "S15", "S16", "S18", "S19" ], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "What was read in this work was the KO/evidence/bibliography/historical-access content of the retained summaries. Distinguish historical records of the reproduced HTML for S01, supplementary PDF for S06, full text for S09, and official safety full texts from the current non-reading of all external materials. snapshot_policy covers limited extraction/bibliography, not redistributed copies of original full texts. Link summary reading through exact locations/values and retained-summary SHAs.", "condition_status": "Met", "status_reason": "This verifies exact retained-summary linkage. It is not current clinical full-text reading or verification of external original bytes.", "missingness": "This verifies exact retained-summary linkage. It is not current clinical full-text reading or verification of external original bytes.", "uncertainty": "This verifies exact retained-summary linkage. It is not current clinical full-text reading or verification of external original bytes.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Physical type, historical access level/location, current non-reading, and retained-summary pointer/literal/SHA for each material" }, { "item_id": "N44", "question_type": "Identity, dates, and updates", "question": "Is historical deployment metadata being read as publication in this work?", "needed": "Current ID/URL, evidence/review dates, original revision/deployment metadata, and links between update events/criteria versions", "role": "Required (selected handgrip question)", "role_reason": "Needed to avoid presenting historical site deployment and current local-sheet creation as the same completion.", "application_exception": "Preserve original materials, unfavorable results, unverified information, and assessments; record changed conditions and new evidence separately.", "criterion": "Distinguish current identity/original dates from this review/unpublished status and establish update rules for linked rows.", "basis": "Internal case-specific adaptation of the retained M03/M04/M08/M15/M19 principles on questions, families, measurement/analysis/uncertainty, and harms. This is not formal application of a methodology or clinical certification.", "condition_origin": "Development criteria created with knowledge of the current retained 3117 material after actually reading it. These are not blinded, prospectively preregistered, or independently clinically validated criteria.", "proposed_research": "If new materials/corrections are permitted, preserve the full original text and review it with links to events, versions, and change decisions.", "current_reports": [], "existence": "Current stored bibliographic/extraction records and historical access records exist. This is not up-to-date external verification of existence or corrections.", "acquired_read": "Only the designated retained summaries were actually read. External original texts and older separate files remain unread in this work.", "observation": "Preserve current ID3117, the original URL, the 2026-09-16 cutoff/publication date, historical server_deployed metadata, and revision_history. The review date of the retained sheet is 2026-10-05, and no public deployment was performed in that review. New eligible comparisons, original methods/strata, plans, or corrections/errors trigger separate review of rows/conditions/materials.", "condition_status": "Met", "status_reason": "This verifies preservation of identity/date/update links. It is not publication in this work or verification of the latest corrections.", "missingness": "This verifies preservation of identity/date/update links. It is not publication in this work or verification of the latest corrections.", "uncertainty": "This verifies preservation of identity/date/update links. It is not publication in this work or verification of the latest corrections.", "review_date": "2026-10-05", "reading_status": "Original source not read · Stored summary read", "additional_material": "Current ID/URL, evidence/review dates, original revision/deployment metadata, and links between update events/criteria versions" } ], "reports": [ { "report_id": "S01", "title": "Wilkinson et al. 1997. The response to treatment of subclinical thiamine deficiency in the elderly", "url": "https://www.academia.edu/18660919/The_response_to_treatment_of_subclinical_thiamine_deficiency_in_the_elderly", "report_type": "Adjacent RCT in older adults with low TPP", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF01", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Full original text reproduced by a third-party host; primary publisher DOI/ScienceDirect access failed. Two-column text extraction has layout artifacts. Grip test, design and results prose distinguishable; no quantitative grip-change contrast in Table 3. · Although 10 mg/day for 3 months was compared with placebo, no quantitative handgrip treatment contrast, CI, or exact P value was reported. Nonsignificance was not treated as equivalence or no effect. · Denominator: 76 participants; 38 thiamine, 38 placebo; all completed · Role: The closest controlled trial, but excluded from target efficacy scoring because the population did not match objectively weak adults", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S01-M1", "url": null, "parent_url": "https://www.academia.edu/18660919/The_response_to_treatment_of_subclinical_thiamine_deficiency_in_the_elderly" }, { "material_type": "Original-article HTML reproduced by a 3rd-party host", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S01-M2", "url": "https://www.academia.edu/18660919/The_response_to_treatment_of_subclinical_thiamine_deficiency_in_the_elderly", "parent_url": "https://www.academia.edu/18660919/The_response_to_treatment_of_subclinical_thiamine_deficiency_in_the_elderly" } ], "links": [ { "label": "Source", "url": "https://www.academia.edu/18660919/The_response_to_treatment_of_subclinical_thiamine_deficiency_in_the_elderly" } ] }, { "report_id": "S02", "title": "Wilkinson 1997 bibliographic record", "url": "https://pubmed.ncbi.nlm.nih.gov/9322569/", "report_type": "TF01 bibliography/index", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF01", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Direct page returned no readable lines; metadata also corroborated by original reproduction.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S02-M1", "url": null, "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9322569/" }, { "material_type": "PubMed bibliographic/indexed excerpt", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S02-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/9322569/", "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9322569/" } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/9322569/" } ] }, { "report_id": "S03", "title": "Bager et al. 2021. Randomised clinical trial: high-dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease", "url": "https://onlinelibrary.wiley.com/doi/10.1111/apt.16166", "report_type": "Adjacent IBD fatigue RCT", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF02", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "The /full address redirected to /abs; encoded /full timed out. Grip text is an indexed excerpt, not full-text verification. Existing fatigue verdict 3086 is unchanged. · Although 600–1,800 mg/day was administered for 4 weeks per period, the population was not recruited for objective weakness, and a quantitative handgrip effect/CI could not be verified. · Denominator: 40 participants; handgrip analysis denominator unverified · Role: Excluded because of the fatigue population/endpoint mismatch", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S03-M1", "url": null, "parent_url": "https://onlinelibrary.wiley.com/doi/10.1111/apt.16166" }, { "material_type": "Publisher abstract/indexed handgrip excerpt", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S03-M2", "url": "https://onlinelibrary.wiley.com/doi/10.1111/apt.16166", "parent_url": "https://onlinelibrary.wiley.com/doi/10.1111/apt.16166" } ], "links": [ { "label": "Source", "url": "https://onlinelibrary.wiley.com/doi/10.1111/apt.16166" } ] }, { "report_id": "S04", "title": "Bager 2021 publisher-provided first-page preview", "url": "https://www.researchgate.net/publication/346485359_Randomised_clinical_trial_high-dose_oral_thiamine_versus_placebo_for_chronic_fatigue_in_patients_with_quiescent_inflammatory_bowel_disease", "report_type": "TF02 first-page/abstract preview", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF02", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Only first page and abstract/figure captions read; later citing papers on the same web page are not the original trial.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S04-M1", "url": null, "parent_url": "https://www.researchgate.net/publication/346485359_Randomised_clinical_trial_high-dose_oral_thiamine_versus_placebo_for_chronic_fatigue_in_patients_with_quiescent_inflammatory_bowel_disease" }, { "material_type": "ResearchGate first-page preview/abstract", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S04-M2", "url": "https://www.researchgate.net/publication/346485359_Randomised_clinical_trial_high-dose_oral_thiamine_versus_placebo_for_chronic_fatigue_in_patients_with_quiescent_inflammatory_bowel_disease", "parent_url": "https://www.researchgate.net/publication/346485359_Randomised_clinical_trial_high-dose_oral_thiamine_versus_placebo_for_chronic_fatigue_in_patients_with_quiescent_inflammatory_bowel_disease" } ], "links": [ { "label": "Source", "url": "https://www.researchgate.net/publication/346485359_Randomised_clinical_trial_high-dose_oral_thiamine_versus_placebo_for_chronic_fatigue_in_patients_with_quiescent_inflammatory_bowel_disease" } ] }, { "report_id": "S05", "title": "Artiukhov et al. 2024. Pharmacological Doses of Thiamine Benefit Patients with the Charcot–Marie–Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes", "url": "https://link.springer.com/article/10.1134/S0006297924070010", "report_type": "CMT uncontrolled mixed-treatment report", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF03", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Main body subscription-restricted. A healthy metabolic comparison group is not a verified untreated longitudinal grip comparator. · Hydrochloride, sulbutiamine, benfotiamine, and other treatments were not pooled or repurposed as a causal between-group handgrip effect. · Denominator: 15 participants in the supplementary material (14 adults); 5 adults receiving hydrochloride, 2 participants verified in the long-term handgrip figure · Role: Excluded because of the uncontrolled design, mixed formulations, and age mismatch", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S05-M1", "url": null, "parent_url": "https://link.springer.com/article/10.1134/S0006297924070010" }, { "material_type": "Publisher abstract/funding, ethics, and correction metadata", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S05-M2", "url": "https://link.springer.com/article/10.1134/S0006297924070010", "parent_url": "https://link.springer.com/article/10.1134/S0006297924070010" } ], "links": [ { "label": "Source", "url": "https://link.springer.com/article/10.1134/S0006297924070010" } ] }, { "report_id": "S06", "title": "Artiukhov 2024 electronic supplementary materials", "url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1134%2FS0006297924070010/MediaObjects/10541_2024_2710_MOESM1_ESM.pdf", "report_type": "CMT supplementary material", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF03", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "All 3 pages inspected with PDF screenshots. Mixed ages, thiamine-HCl/derivative exposures and other-therapy rows retained separately. Figure S2 concerns biomarkers, not a grip treatment contrast.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S06-M1", "url": null, "parent_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1134%2FS0006297924070010/MediaObjects/10541_2024_2710_MOESM1_ESM.pdf" }, { "material_type": "Electronic supplementary PDF, 3 pages", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S06-M2", "url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1134%2FS0006297924070010/MediaObjects/10541_2024_2710_MOESM1_ESM.pdf", "parent_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1134%2FS0006297924070010/MediaObjects/10541_2024_2710_MOESM1_ESM.pdf" } ], "links": [ { "label": "Source", "url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1134%2FS0006297924070010/MediaObjects/10541_2024_2710_MOESM1_ESM.pdf" } ] }, { "report_id": "S07", "title": "Artiukhov 2024 Russian-language report/figure captions", "url": "https://cardiosomatics.ru/0320-9725/article/view/676549", "report_type": "CMT translation/figures for the same cohort", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF03", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Same cohort/translation, not replication. Figure 1 describes patients 1 and 3 receiving thiamine-HCl and patient 2 sulbutiamine; main text restricted.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S07-M1", "url": null, "parent_url": "https://cardiosomatics.ru/0320-9725/article/view/676549" }, { "material_type": "Russian publisher abstract/figure descriptions", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S07-M2", "url": "https://cardiosomatics.ru/0320-9725/article/view/676549", "parent_url": "https://cardiosomatics.ru/0320-9725/article/view/676549" } ], "links": [ { "label": "Source", "url": "https://cardiosomatics.ru/0320-9725/article/view/676549" } ] }, { "report_id": "S08", "title": "Erratum to Artiukhov et al. 2024", "url": "https://link.springer.com/article/10.1134/S0006297924090116", "report_type": "CMT correction notice", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF03", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Formal erratum exists; full correction body inaccessible. Main original publisher separately states page-range correction from 1–22 to 1161–1182. Table-3 gray-shading detail was found only in a search excerpt and is not promoted to verified full-text fact.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S08-M1", "url": null, "parent_url": "https://link.springer.com/article/10.1134/S0006297924090116" }, { "material_type": "Publisher correction notice (full text unacquired)", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S08-M2", "url": "https://link.springer.com/article/10.1134/S0006297924090116", "parent_url": "https://link.springer.com/article/10.1134/S0006297924090116" } ], "links": [ { "label": "Source", "url": "https://link.springer.com/article/10.1134/S0006297924090116" } ] }, { "report_id": "S09", "title": "Costantini et al. 2016. High-dose thiamine improves the symptoms of myotonic dystrophy type 1", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5090854/", "report_type": "Two intramuscular DM1 cases", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF04", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Two cases, intramuscular thiamine 100 mg twice weekly, not oral single-ingredient controlled dynamometer evidence.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S09-M1", "url": null, "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5090854/" }, { "material_type": "PMC original-article HTML", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S09-M2", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5090854/", "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5090854/" } ], "links": [ { "label": "Source", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5090854/" } ] }, { "report_id": "S10", "title": "Smidt et al. 1991. Influence of Thiamin Supplementation on the Health and General Well-being of an Elderly Irish Population With Marginal Thiamin Deficiency", "url": "https://academic.oup.com/geronj/article-abstract/46/1/M16/638741", "report_type": "Well-being trial in healthy older women", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF05", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Eighty healthy elderly women; 10 mg/day, six-week double-blind treatment after four-week baseline. Low-strength requirement and isolated objective strength contrast not verified; no benefit borrowed from well-being outcomes.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S10-M1", "url": null, "parent_url": "https://academic.oup.com/geronj/article-abstract/46/1/M16/638741" }, { "material_type": "Publisher indexed abstract", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S10-M2", "url": "https://academic.oup.com/geronj/article-abstract/46/1/M16/638741", "parent_url": "https://academic.oup.com/geronj/article-abstract/46/1/M16/638741" } ], "links": [ { "label": "Source", "url": "https://academic.oup.com/geronj/article-abstract/46/1/M16/638741" } ] }, { "report_id": "S11", "title": "Nishiyama et al. 1972. Effect of thiamine tetrahydrofurfuryl disulfide (TTFD) on physical fitness chiefly on muscle strength—double blind studies", "url": "https://www.jstage.jst.go.jp/article/jspfsm1949/21/1/21_1_6/_article", "report_type": "TTFD original-article title", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF06", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "TTFD entity exclusion verified from original title. Full paper not extracted; no numerical result asserted.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S11-M1", "url": null, "parent_url": "https://www.jstage.jst.go.jp/article/jspfsm1949/21/1/21_1_6/_article" }, { "material_type": "J-STAGE original-article landing page", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S11-M2", "url": "https://www.jstage.jst.go.jp/article/jspfsm1949/21/1/21_1_6/_article", "parent_url": "https://www.jstage.jst.go.jp/article/jspfsm1949/21/1/21_1_6/_article" } ], "links": [ { "label": "Source", "url": "https://www.jstage.jst.go.jp/article/jspfsm1949/21/1/21_1_6/_article" } ] }, { "report_id": "S12", "title": "Doyle et al. 1997. Allithiamine ingestion does not enhance isokinetic parameters of muscle performance", "url": "https://pubmed.ncbi.nlm.nih.gov/9063763/", "report_type": "Allithiamine isokinetic trial in healthy students", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF07", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "15 healthy college students; oral allithiamine 1 g/day for 5 days, placebo crossover; Biodex System2. Null statistical findings do not establish equivalence and concern a derivative and a different population. · The nonsignificant (P>0.05) result for allithiamine 1 g/day for 5 days does not establish no effect or equivalence for ordinary thiamine, adults with low muscle strength, and handgrip. · Denominator: 15 participants · Role: Excluded because of the derivative, healthy participants, and different muscle-strength endpoint", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S12-M1", "url": null, "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9063763/" }, { "material_type": "PubMed original-article abstract", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S12-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/9063763/", "parent_url": "https://pubmed.ncbi.nlm.nih.gov/9063763/" } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/9063763/" } ] }, { "report_id": "S13", "title": "Ohkoshi et al. 2006. Functional Limitations in Thiamine Deficiency Neuropathy: FIM Score Improvement With Treatment", "url": "https://www.ovid.com/jnls/jcnmd/fulltext/10.1097/01.cnd.0000203643.84628.a1~functional-limitations-in-thiamine-deficiency-neuropathy-fim", "report_type": "Deficiency neuropathy FIM report", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF08", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "FIM functional limitation outcome, not verified isolated muscle-strength trial. Detailed methods inaccessible; do not infer oral formulation or comparator.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S13-M1", "url": null, "parent_url": "https://www.ovid.com/jnls/jcnmd/fulltext/10.1097/01.cnd.0000203643.84628.a1~functional-limitations-in-thiamine-deficiency-neuropathy-fim" }, { "material_type": "Indexed abstract excerpt (full-text 402 failure)", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S13-M2", "url": "https://www.ovid.com/jnls/jcnmd/fulltext/10.1097/01.cnd.0000203643.84628.a1~functional-limitations-in-thiamine-deficiency-neuropathy-fim", "parent_url": "https://www.ovid.com/jnls/jcnmd/fulltext/10.1097/01.cnd.0000203643.84628.a1~functional-limitations-in-thiamine-deficiency-neuropathy-fim" } ], "links": [ { "label": "Source", "url": "https://www.ovid.com/jnls/jcnmd/fulltext/10.1097/01.cnd.0000203643.84628.a1~functional-limitations-in-thiamine-deficiency-neuropathy-fim" } ] }, { "report_id": "S14", "title": "NIH ODS. Thiamin—Health Professional Fact Sheet", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/?uid=bd05fc9162499s16", "report_type": "Official thiamine safety overview", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": null, "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Canonical address first failed; indexed query-parameter URL yielded full text. Safety context, not efficacy trial evidence.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S14-M1", "url": null, "parent_url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/?uid=bd05fc9162499s16" }, { "material_type": "NIH official HTML overview", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S14-M2", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/?uid=bd05fc9162499s16", "parent_url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/?uid=bd05fc9162499s16" } ], "links": [ { "label": "Source", "url": "https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/?uid=bd05fc9162499s16" } ] }, { "report_id": "S15", "title": "Thiamine Hydrochloride 100 mg Tablets—SmPC", "url": "https://www.medicines.org.uk/emc/product/13528/smpc", "report_type": "SmPC for a separate 100 mg HCl product", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": null, "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Product-specific oral hydrochloride; does not establish safety for all products or higher doses. Parenteral predominance of hypersensitivity reports explicitly retained.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S15-M1", "url": null, "parent_url": "https://www.medicines.org.uk/emc/product/13528/smpc" }, { "material_type": "emc official product information", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S15-M2", "url": "https://www.medicines.org.uk/emc/product/13528/smpc", "parent_url": "https://www.medicines.org.uk/emc/product/13528/smpc" } ], "links": [ { "label": "Source", "url": "https://www.medicines.org.uk/emc/product/13528/smpc" } ] }, { "report_id": "S16", "title": "Institute of Medicine 1998. Dietary Reference Intakes, Chapter4: Thiamin", "url": "https://www.ncbi.nlm.nih.gov/books/NBK114331/", "report_type": "Official dietary-intake/UL chapter", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": null, "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "No UL because inadequate toxicity data, not proof of unlimited safety. Dialysis/malabsorption may alter requirements; no therapeutic high-dose ceiling derived.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S16-M1", "url": null, "parent_url": "https://www.ncbi.nlm.nih.gov/books/NBK114331/" }, { "material_type": "NCBI official dietary-intake HTML chapter", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S16-M2", "url": "https://www.ncbi.nlm.nih.gov/books/NBK114331/", "parent_url": "https://www.ncbi.nlm.nih.gov/books/NBK114331/" } ], "links": [ { "label": "Source", "url": "https://www.ncbi.nlm.nih.gov/books/NBK114331/" } ] }, { "report_id": "S17", "title": "NICE CG32. Nutrition support for adults", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations", "report_type": "Combined refeeding-management recommendations", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": null, "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Supervised thiamine within a multi-component nutrition/refeeding regimen; not isolated strength efficacy evidence. Direct main and alternate chapter URLs failed.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S17-M1", "url": null, "parent_url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" }, { "material_type": "NICE indexed recommendation excerpt (full-page access failed)", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S17-M2", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations", "parent_url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" } ], "links": [ { "label": "Source", "url": "https://www.nice.org.uk/guidance/cg32/chapter/recommendations" } ] }, { "report_id": "S18", "title": "ClinicalTrials.gov NCT03634735", "url": "https://clinicaltrials.gov/study/NCT03634735", "report_type": "TARIF registration-access attempt", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF02", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Record identifier verified in original report; official page shell, web API internal error and native API DNS failure. Prospective timing not independently verified.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S18-M1", "url": null, "parent_url": "https://clinicaltrials.gov/study/NCT03634735" }, { "material_type": "ClinicalTrials.gov shell (record body/history unacquired)", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S18-M2", "url": "https://clinicaltrials.gov/study/NCT03634735", "parent_url": "https://clinicaltrials.gov/study/NCT03634735" } ], "links": [ { "label": "Source", "url": "https://clinicaltrials.gov/study/NCT03634735" } ] }, { "report_id": "S19", "title": "Bager TARIF family later publications as supplied in prior snapshot3086", "url": "https://link.springer.com/article/10.1186/s10020-023-00741-3", "report_type": "Supplied records of multiple TARIF follow-up reports", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF02", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Oral HCl form and same-TARIF metabolic analysis provenance reused solely to map new strength question. PMID34592862 maintenance follow-up also mapped here. No fatigue assessment regraded. User-supplied snapshot, not claimed newly verified original.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S19-M1", "url": null, "parent_url": "https://link.springer.com/article/10.1186/s10020-023-00741-3" }, { "material_type": "Extraction of multiple follow-up reports from previously supplied retained summaries", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "S19/S21 are entries containing multiple reports/supplied materials; a single external URL is not guaranteed to be a direct full-text link to the same material.", "material_id": "S19-M2", "url": null, "parent_url": "https://link.springer.com/article/10.1186/s10020-023-00741-3" } ], "links": [ { "label": "Source", "url": "https://link.springer.com/article/10.1186/s10020-023-00741-3" } ] }, { "report_id": "S20", "title": "Bager et al. 2024. High-dose oral thiamine versus placebo for chronic fatigue in primary biliary cholangitis", "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301354", "report_type": "PBC fatigue trial", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF09", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Different disease and fatigue endpoint; not counted as strength refutation or replication. No fatigue effect size imported.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S20-M1", "url": null, "parent_url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301354" }, { "material_type": "Indexed abstract excerpt from an original article", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S20-M2", "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301354", "parent_url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301354" } ], "links": [ { "label": "Source", "url": "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0301354" } ] }, { "report_id": "S21", "title": "2026 B-vitamins/magnesium IBD trial", "url": "https://www.nature.com/articles/s41598-026-49880-7", "report_type": "Lead for an IBD B-vitamin/magnesium combination trial", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF10", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "B1/B6/B12+magnesium combination and fatigue question; ineligible for isolated B1 strength. No new regrading.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S21-M1", "url": null, "parent_url": "https://www.nature.com/articles/s41598-026-49880-7" }, { "material_type": "Indexed title/previously supplied composition extraction", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "S19/S21 are entries containing multiple reports/supplied materials; a single external URL is not guaranteed to be a direct full-text link to the same material.", "material_id": "S21-M2", "url": null, "parent_url": "https://www.nature.com/articles/s41598-026-49880-7" } ], "links": [ { "label": "Source", "url": "https://www.nature.com/articles/s41598-026-49880-7" } ] }, { "report_id": "S22", "title": "Thiamine pharmacologic protocols review (evidence map only)", "url": "https://www.mdpi.com/2077-0383/14/11/3787", "report_type": "Review literature map", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": null, "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Not used for decisive numbers or scoring.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S22-M1", "url": null, "parent_url": "https://www.mdpi.com/2077-0383/14/11/3787" }, { "material_type": "Indexed review excerpt", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S22-M2", "url": "https://www.mdpi.com/2077-0383/14/11/3787", "parent_url": "https://www.mdpi.com/2077-0383/14/11/3787" } ], "links": [ { "label": "Source", "url": "https://www.mdpi.com/2077-0383/14/11/3787" } ] }, { "report_id": "S23", "title": "Association of Micronutrients and Handgrip Strength in Korean Adults", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9602344/", "report_type": "Dietary micronutrient/handgrip observation", "existence": "Stored bibliographic/historical-access record. No current external existence/correction/retraction lookup was performed in this work.", "acquired_read": "The designated retained summary was actually read. External/old separate original sources have not been read in the current work.", "study_family": "TF11", "independent_replication": "Distinguish report, bibliographic/safety, registration, and family roles; do not count 23 entries as 23 trials.", "observed_result": "Dietary micronutrient association, not an oral single-ingredient intervention; no dietary dose converted to supplement dose.", "result_level": "A retained summary within the historical extraction/access scope; not new verification of original clinical evidence.", "materials": [ { "material_type": "Retained summary of bibliography, limited extraction, and historical access", "public_status": "Locally retained", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "Exact stored-manuscript location/value/SHA. Not the original bytes of a clinical full text.", "material_id": "S23-M1", "url": null, "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9602344/" }, { "material_type": "Indexed excerpt from an original observational article", "public_status": "Unverified (no external lookup in this work)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "Distinguish historical access level/success/failure from current non-attempted external access. The existence of a link is not a current reading record.", "material_id": "S23-M2", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9602344/", "parent_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9602344/" } ], "links": [ { "label": "Source", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9602344/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility criteria and reasons for changes, and distinguish variations in the intervention.", "review_level": "Records reuse of retained methodological principles/versions and the 5 actual HTML copies from 1585. This is not new reading of methodological full texts or an official execution/certification in the current work." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish and link studies and reports, and do not omit a study solely because its outcomes are not reported.", "review_level": "Records reuse of retained methodological principles/versions and the 5 actual HTML copies from 1585. This is not new reading of methodological full texts or an official execution/certification in the current work." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Hold the outcome and effect of interest fixed, then assess randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Records reuse of retained methodological principles/versions and the 5 actual HTML copies from 1585. This is not new reading of methodological full texts or an official execution/certification in the current work." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Records reuse of retained methodological principles/versions and the 5 actual HTML copies from 1585. This is not new reading of methodological full texts or an official execution/certification in the current work." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Questions about harms may require designs, populations and follow-up different from efficacy questions. Case reports do not establish incidence.", "review_level": "Records reuse of retained methodological principles/versions and the 5 actual HTML copies from 1585. This is not new reading of methodological full texts or an official execution/certification in the current work." } ], "status_dictionary": { "Partly verified": "Some retained information exists, but gaps remain in eligible populations/exposures, measurements/denominators/estimates, original-source access, and related details.", "Unverified": "The necessary information/conditions cannot be established within the current verification scope.", "Review incomplete": "Original-material comparison/search was not performed within the permitted scope.", "Not reported": "A scope-limited status indicating that the item was not stated in the particular material/section read.", "Inaccessible": "Used only for materials for which access was actually attempted and failed. Not assigned to clinical materials in the current work.", "Insufficient eligible evidence": "Used only when, after reviewing related studies within a defined scope, evidence is insufficient to answer the specified question. Not applied across all entries in this work.", "Not applicable": "Specific non-applicability: separate extension studies are not imposed on the current narrow handgrip question. Not a substitute for unverified actual exposure/population/outcomes.", "Conflicting information": "Used when incompatible information has been compared for the same question, time point, and analysis. Not assigned merely because numbers differ between reviews.", "Met": "Verification of the stated preservation, boundary/distinction, or linkage conditions. Not certification of clinical efficacy, external full-text reading, or individual safety." }, "study_overlap": { "state": "These are report links from the stored manuscript. TF01 · near_match_indirect · No objectively weak population or low-strength stratum defined; low TPP and low group-average grip do not establish every participant or a prespecified subgroup had reduced strength. (S01, S02) / TF02 · near_match_indirect · Enrollment on quiescent IBD and severe chronic fatigue; no objectively weak enrollment group or low-strength treatment stratum verified. Handgrip secondary result excerpt does not repair this boundary. (S03, S04, S18, S19) / TF03 · near_match_indirect · No matched untreated/placebo longitudinal grip comparison verified. Mixed forms, durations, ages and outcome denominators are not pooled as a pure oral adult trial. (S05, S06, S07, S08) / TF04 · case_report_injection · IM route, two uncontrolled DM1 cases; not oral dynamometer trial. (S09) / TF05 · healthy_elderly_wellbeing_trial · Healthy elderly women; baseline objective weakness and strength result not verified. (S10) / TF06 · derivative_strength_trial · TTFD is a distinct molecular derivative; not ordinary thiamine. (S11) / TF07 · derivative_healthy_students_trial · Allithiamine, healthy students; do not borrow the nonsignificant isokinetic result. (S12) / TF08 · functional_recovery_report · FIM is general function, not isolated validated strength endpoint; route/comparison unverified. (S13) / TF09 · different_disease_fatigue_trial · PBC fatigue not the target strength endpoint. (S20) / TF10 · combination_fatigue_trial · B-vitamins+magnesium cannot isolate ordinary thiamine strength efficacy. (S21) / TF11 · dietary_observational_study · Dietary micronutrient association not supplement randomization; intake not converted to dose. (S23) The overall unique trial count and total participant count remain unverified. Verification of retained summaries is distinguished from non-reading of original materials in this work; report/family labels are not summed as total trials or participants.", "unique_trial_count": null, "unique_participant_count": null, "reason": "These are report links from the stored manuscript. TF01 · near_match_indirect · No objectively weak population or low-strength stratum defined; low TPP and low group-average grip do not establish every participant or a prespecified subgroup had reduced strength. (S01, S02) / TF02 · near_match_indirect · Enrollment on quiescent IBD and severe chronic fatigue; no objectively weak enrollment group or low-strength treatment stratum verified. Handgrip secondary result excerpt does not repair this boundary. (S03, S04, S18, S19) / TF03 · near_match_indirect · No matched untreated/placebo longitudinal grip comparison verified. Mixed forms, durations, ages and outcome denominators are not pooled as a pure oral adult trial. (S05, S06, S07, S08) / TF04 · case_report_injection · IM route, two uncontrolled DM1 cases; not oral dynamometer trial. (S09) / TF05 · healthy_elderly_wellbeing_trial · Healthy elderly women; baseline objective weakness and strength result not verified. (S10) / TF06 · derivative_strength_trial · TTFD is a distinct molecular derivative; not ordinary thiamine. (S11) / TF07 · derivative_healthy_students_trial · Allithiamine, healthy students; do not borrow the nonsignificant isokinetic result. (S12) / TF08 · functional_recovery_report · FIM is general function, not isolated validated strength endpoint; route/comparison unverified. (S13) / TF09 · different_disease_fatigue_trial · PBC fatigue not the target strength endpoint. (S20) / TF10 · combination_fatigue_trial · B-vitamins+magnesium cannot isolate ordinary thiamine strength efficacy. (S21) / TF11 · dietary_observational_study · Dietary micronutrient association not supplement randomization; intake not converted to dose. (S23) The overall unique trial count and total participant count remain unverified. Verification of stored summaries is distinguished from non-reading of original materials in this work; report/family labels are not summed as total trials or participants." }, "history": [ { "date": "2026-11-06", "kind": "Separation of public-facing display and data", "view_version": "1.0", "change": "Public-facing display and data were prepared from the existing 44 items. No new clinical search, verification-status change, or scoring was performed." } ], "language": "en", "translation_date": "2026-11-06" }