{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3100-main", "verdict_number": "3100", "title": "Oral single-active-ingredient pantothenic acid (vitamin B5) supplementation × Reduction in LDL-C concentration in adults with elevated LDL-C", "view_version": "1.0", "view_created_date": "2026-11-02", "criteria_version": "NGM-v3100-SOLE-ORAL-B5-ELEVATED-LDL-C-1.0", "criteria_date": "2026-10-05", "review_date": "2026-10-05", "legacy_evidence_date": "2026-09-15", "review_scope": { "materials_read": "Archived Korean and English manuscripts and case-specific conditions and application records", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "No external clinical abstracts, full texts, registrations, or analysis plans were newly read. Historical access records are distinguished from the current reading of archived summaries. The original judgment, numerical values, and unverified matters were preserved, and no new search, calculation, or regrading was performed.", "date_meaning": "This is the date the archived material was checked, not the date of the latest clinical literature search." }, "claim_context": { "population": "Adults with elevated LDL-C; actual diagnostic criteria, baseline values, medications, and deficiency status unverified", "intervention": "Pantothenic acid (vitamin B5) as the sole active ingredient; calcium salt to be verified separately · Oral product with a single active ingredient; exact salt, tablet/capsule, and release type unverified", "dose": "Unverified — eligible pantothenic-acid monotherapy dose and frequency not verified", "comparator": "Placebo or usual care on the same background treatment; actual composition and shared treatment unverified", "endpoint": "Between-group difference in change in LDL-C concentration (mg/dL or mmol/L); endpoint difference separate, actual eligible results unverified", "duration": "Unverified — eligible monotherapy treatment duration and time points not verified", "excluded_extensions": "Extensions to pantethine/pantetheine/other molecules, B-complex products, nonhuman mechanisms, skin/hair/acne, LDL oxidative stability, cardiovascular events/replacement of lipid-lowering medication, optimal dose/persistence, and all populations are separate." }, "requirements": [ { "item_id": "N01", "question_type": "Independent claim", "question": "Which ingredient, population, and LDL-C comparison?", "needed": "Adults with elevated LDL-C, oral B5 monotherapy, comparator with the same background treatment, between-group change in LDL-C", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid combining all lipid-related efficacy claims for the ingredient into a single question.", "application_exception": "Pantethine, multicomponent products, acne, and clinical events are separate questions.", "criterion": "Link the current original effect wording and inclusion/exclusion boundaries to exact locations.", "basis": "Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are internally designed; M03 §3.2.1; detailed population conditions are internally designed; M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare differences in ingredient, population, endpoint, and comparison between the existing question and candidate results for each material.", "current_reports": [ "S101", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The selected question is whether oral treatment with pantothenic acid as the sole active ingredient lowers LDL-C concentration more than placebo or usual care on the same background treatment in adults with elevated LDL-C. subclaims is an empty list.", "condition_status": "Met", "status_reason": "This verifies the identity of the question, not direct efficacy.", "missingness": "This verifies the identity of the question, not direct efficacy.", "uncertainty": "This verifies the identity of the question, not direct efficacy.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Adults with elevated LDL-C, oral B5 monotherapy, comparator with the same background treatment, between-group change in LDL-C" }, { "item_id": "N02", "question_type": "Molecule and route", "question": "Are pantothenic acid and pantethine the same intervention?", "needed": "Exact molecule, salt, active ingredient, and route of administration", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid transferring clinical results solely on the basis of a description as a derivative.", "application_exception": "Verify the exact salt of calcium pantothenate separately and perform no new mass conversion.", "criterion": "Link differences in substance, combination, and route to the original text and explain the limits of direct attribution.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare product composition and chemical-form documents for each result to verify whether the active ingredient is the same.", "current_reports": [ "S101", "S06", "L028" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Pantethine is a different substance from pantothenic acid. pantetheine, dexpanthenol/panthenol, and B-complex products were distinguished from the direct intervention, and the exact identity of the calcium salt remained unverified.", "condition_status": "Met", "status_reason": "Verifying the substance boundary is separate from verifying the specifications of an eligible product.", "missingness": "Verifying the substance boundary is separate from verifying the specifications of an eligible product.", "uncertainty": "Verifying the substance boundary is separate from verifying the specifications of an eligible product.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Exact molecule, salt, active ingredient, and route of administration" }, { "item_id": "N03", "question_type": "Product specifications", "question": "Are the origin, salt, and formulation of an eligible single-active-ingredient product known?", "needed": "Manufacturing origin, brand, exact salt, purity, batch, tablet/capsule, and release type", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid inserting the specifications of another molecule or multicomponent product into those of the directly relevant product.", "application_exception": "An oral single-active-ingredient product specified in the question is not an actual product specification.", "criterion": "Distinguish verified values for a directly eligible formulation from unverified product items.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Verify formulation analysis, batch, and composition materials by linking them to actual comparative trial results.", "current_reports": [ "S101", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The origin, brand, salt, purity, batch, formulation, and release type of an eligible pantothenic-acid single-active-ingredient product are unverified.", "condition_status": "Unverified", "status_reason": "Specifications not supplied by the current material were not taken from related products.", "missingness": "Specifications not supplied by the current material were not taken from related products.", "uncertainty": "Specifications not supplied by the current material were not taken from related products.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Manufacturing origin, brand, exact salt, purity, batch, tablet/capsule, and release type" }, { "item_id": "N04", "question_type": "Dose and frequency", "question": "What are the actual dose and total exposure for B5 monotherapy?", "needed": "Single-active-ingredient dose, frequency, active amount, dietary/concurrent supplementation, and adherence", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using the pantethine dose as a pantothenic-acid treatment dose.", "application_exception": "The 600/900 mg pantethine doses, nutritional reference values, and examples of high-dose harms are separate records.", "criterion": "Verify the directly eligible dose and actual total exposure, leaving unavailable values unfilled.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M03 §3.2.1–3.2.4; details of dose, duration, and effect modification are internally designed", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Collect administration, composition, adherence, and dietary-exposure records by arm to examine actual differences in intervention.", "current_reports": [ "S101", "S06" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The pantothenic-acid monotherapy dose and frequency are unverified. Evans's initial 600 mg/day and later 900 mg/day are pantethine doses and were not transferred as B5 treatment doses.", "condition_status": "Unverified", "status_reason": "No new calcium-salt mass conversion or personal dosage was created.", "missingness": "No new calcium-salt mass conversion or personal dosage was created.", "uncertainty": "No new calcium-salt mass conversion or personal dosage was created.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Single-active-ingredient dose, frequency, active amount, dietary/concurrent supplementation, and adherence" }, { "item_id": "N05", "question_type": "Duration and time points", "question": "Have the directly relevant treatment duration and assessment time points been verified?", "needed": "Single-active-ingredient administration duration, planned/actual LDL-C time points, and follow-up", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using 16 weeks for another substance as a verified value for the single-active-ingredient treatment.", "application_exception": "Do not arbitrarily specify a universal minimum treatment duration.", "criterion": "Distinguish eligible single-active-ingredient durations and time points from the duration of a related trial.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M04 §4.6.3; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the plan, actual exposure, and time points in outcome tables to distinguish prespecified endpoints from follow-up.", "current_reports": [ "S101", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Eligible monotherapy treatment duration and LDL-C assessment time points are unverified. 16 weeks is the duration of the Evans pantethine trial.", "condition_status": "Unverified", "status_reason": "Duration for a different molecule does not meet the selected comparison.", "missingness": "Duration for a different molecule does not meet the selected comparison.", "uncertainty": "Duration for a different molecule does not meet the selected comparison.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Single-active-ingredient administration duration, planned/actual LDL-C time points, and follow-up" }, { "item_id": "N06", "question_type": "Population selection", "question": "How were adults with elevated LDL-C selected?", "needed": "Diagnostic threshold, baseline LDL-C, age, inclusion/exclusion, and setting", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid mistaking the population label in the question for actual recruitment criteria.", "application_exception": "Do not transfer the cardiovascular-risk and statin-eligible population of a pantethine trial to the single-active-ingredient population.", "criterion": "Explain the actual recruitment/diagnosis in directly eligible studies and what remains unverified.", "basis": "M03 §3.2.1; detailed population conditions are internally designed", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Obtain recruitment and baseline tables and exclusion criteria, and compare them with the population in the selected question.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The question was fixed to adults with elevated LDL-C, but the diagnostic threshold, baseline values, and selection criteria in directly relevant monotherapy trials are unverified.", "condition_status": "Unverified", "status_reason": "The population of a related trial is attributed only to that trial.", "missingness": "The population of a related trial is attributed only to that trial.", "uncertainty": "The population of a related trial is attributed only to that trial.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Diagnostic threshold, baseline LDL-C, age, inclusion/exclusion, and setting" }, { "item_id": "N07", "question_type": "Baseline and concomitant treatment", "question": "Can lipid-lowering medications, diet, deficiency, and other supplementation be distinguished?", "needed": "Arm-specific lipid-lowering medications, diet, deficiency/nutritional status, and concurrent supplementation", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using differences in background treatment and correction of deficiency as an additional B5 effect.", "application_exception": "If baseline deficiency is unverified, do not establish that deficiency is absent.", "criterion": "Link the scope and limitations of baseline/concomitant-treatment verification in eligible single-active-ingredient studies.", "basis": "M03 §3.2.1; detailed population conditions are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare baseline nutrition, medications, diet, and records of arm-specific changes with analyses for each outcome.", "current_reports": [ "S101", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Medication, deficiency, and dietary/concurrent-supplementation status in the directly eligible population are unverified.", "condition_status": "Unverified", "status_reason": "The description of a diet-controlled pantethine study is not a concomitant-treatment condition in the selected B5 trial.", "missingness": "The description of a diet-controlled pantethine study is not a concomitant-treatment condition in the selected B5 trial.", "uncertainty": "The description of a diet-controlled pantethine study is not a concomitant-treatment condition in the selected B5 trial.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Arm-specific lipid-lowering medications, diet, deficiency/nutritional status, and concurrent supplementation" }, { "item_id": "N08", "question_type": "Comparator and background treatment", "question": "What are the placebo or usual care and the actual shared treatment?", "needed": "Actual placebo composition, usual care, rescue treatment, and arm-specific changes", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using the planned comparison as verification of the actual comparator arm.", "application_exception": "Do not require all changes in both arms to be identical; examine them in relation to the effect of interest.", "criterion": "Distinguish the actual comparison, differences other than the intervention, and their implications for analysis.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptation to laboratory tests are internally designed; M03 §3.2.3, M08 §8.2.2–8.2.3; internal application; M08 §8.2.2, M15 §15.3.1; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Link arm-specific prescriptions, comparator composition, rescue treatment/changes, and analysis plans to verify the scope of contribution.", "current_reports": [ "S101", "S105", "S106" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Placebo or usual care on the same background treatment is the comparison specified in the question; directly eligible comparator composition and shared treatment are unverified.", "condition_status": "Unverified", "status_reason": "A comparison of two B-complex formulations is not a placebo comparison of B5 monotherapy.", "missingness": "A comparison of two B-complex formulations is not a placebo comparison of B5 monotherapy.", "uncertainty": "A comparison of two B-complex formulations is not a placebo comparison of B5 monotherapy.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Actual placebo composition, usual care, rescue treatment, and arm-specific changes" }, { "item_id": "N09", "question_type": "Measurement method", "question": "Were directly measured LDL and formula-calculated LDL distinguished?", "needed": "LDL measurement method, specimen/blood collection, calculation formula, and arm-specific procedures", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid establishing that values from different measurement methods represent the same endpoint.", "application_exception": "Do not convert other lipid markers or oxidative stability into LDL-C concentration.", "criterion": "Explain the actual measurement conditions for eligible LDL-C results and the scope that cannot be verified.", "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M03 §3.2.4; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare measurement methods, calculation formulas, blood-collection conditions, and assessment procedures with each outcome table.", "current_reports": [ "S101", "S108" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "There is no information to distinguish directly measured LDL from formula-calculated LDL, and measurement procedures in eligible monotherapy trials are unverified.", "condition_status": "Unverified", "status_reason": "Measurement information or results were not filled in through unit conversion or graph reconstruction.", "missingness": "Measurement information or results were not filled in through unit conversion or graph reconstruction.", "uncertainty": "Measurement information or results were not filled in through unit conversion or graph reconstruction.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "LDL measurement method, specimen/blood collection, calculation formula, and arm-specific procedures" }, { "item_id": "N10", "question_type": "Endpoint and units", "question": "Are differences in change, endpoint differences, and percentages the same value?", "needed": "LDL-C definition, units, baseline/change/endpoint values, and between-group/within-group distinctions", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid converting within-group percentages into placebo-adjusted concentration differences.", "application_exception": "Perform no new conversion between mg/dL and mmol/L.", "criterion": "Separate the selected between-group change in concentration from the different measures in related reports.", "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Link outcome definitions, analyses, units, and time points to the original tables and protocol, preserving each separately.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The question concerns the between-group difference in change in LDL-C concentration, with endpoint differences kept separate. Evans's -11%/+3% were distinguished as changes from each arm's baseline and were not converted into a pantothenic-acid concentration difference.", "condition_status": "Met", "status_reason": "This verifies the distinction between measures; it does not mean that single-active-ingredient results were obtained.", "missingness": "This verifies the distinction between measures; it does not mean that single-active-ingredient results were obtained.", "uncertainty": "This verifies the distinction between measures; it does not mean that single-active-ingredient results were obtained.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "LDL-C definition, units, baseline/change/endpoint values, and between-group/within-group distinctions" }, { "item_id": "N11", "question_type": "Effect of interest", "question": "What intervention effect does an eligible analysis estimate?", "needed": "Between-group/within-group, change/endpoint, adjustment, ITT/PP, and analysis population", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid transferring different effect definitions into the same estimate.", "application_exception": "Do not assume ITT or an adjusted effect if no record is available.", "criterion": "Explain how the actual effect definition in directly eligible results agrees with or differs from the question.", "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the analysis plan with actual outcome tables to verify the effect of interest, adjustment, and denominators.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Baseline, change, and endpoint values and actual between-group analyses for B5 monotherapy are unverified.", "condition_status": "Unverified", "status_reason": "Do not fill a direct B5 estimate with related pantethine analyses.", "missingness": "Do not fill a direct B5 estimate with related pantethine analyses.", "uncertainty": "Do not fill a direct B5 estimate with related pantethine analyses.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Between-group/within-group, change/endpoint, adjustment, ITT/PP, and analysis population" }, { "item_id": "N12", "question_type": "Effect and interval", "question": "Are the directly relevant LDL-C effect, CI, and P value known?", "needed": "Eligible between-group effect, uncertainty interval, P value, and units", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid converting an unverified result into an effect of 0 or nonsignificance.", "application_exception": "Do not reconstruct pantethine results, other biomarkers, or graphs as a directly relevant effect.", "criterion": "Distinguish the unverified direct-effect fields from related results.", "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are internally designed; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M15 §15.3.1–15.3.3; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Review estimates, intervals, variance, and denominators in eligible outcome tables by attributing them to the actual analyses.", "current_reports": [ "S101", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Within primary_effect, the records for mean_difference, confidence_interval, p_value, and analysis sample size are empty/not_verified.", "condition_status": "Unverified", "status_reason": "This does not confirm an effect of 0, equivalence, or the absence of a directly relevant effect.", "missingness": "This does not confirm an effect of 0, equivalence, or the absence of a directly relevant effect.", "uncertainty": "This does not confirm an effect of 0, equivalence, or the absence of a directly relevant effect.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Eligible between-group effect, uncertainty interval, P value, and units" }, { "item_id": "N13", "question_type": "Directly relevant denominators", "question": "How many participants were allocated, measured, analyzed, and completed, respectively?", "needed": "Arm-specific allocation/analysis/completion for the single-active-ingredient treatment, missing data, and outcome-specific denominators", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using related sample sizes as directly relevant LDL-C analysis denominators.", "application_exception": "32 allocated and 24 completed are denominators from the pantethine trial.", "criterion": "Distinguish directly relevant outcome-specific denominators from what remains unverified.", "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; design-specific adaptations are internally designed; M08 §8.2.2, M15 §15.3.1; internal application; M15 §15.3.1–15.3.3; internal application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare participant flow, reasons for missing data, and outcome-specific analysis tables to verify denominators.", "current_reports": [ "S101", "S102" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Arm-specific LDL-C analysis denominators and allocated/completed counts in eligible B5 monotherapy trials are unverified.", "condition_status": "Unverified", "status_reason": "Denominators from related studies were not transferred, and no new missing counts or rates were calculated.", "missingness": "Denominators from related studies were not transferred, and no new missing counts or rates were calculated.", "uncertainty": "Denominators from related studies were not transferred, and no new missing counts or rates were calculated.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Arm-specific allocation/analysis/completion for the single-active-ingredient treatment, missing data, and outcome-specific denominators" }, { "item_id": "N14", "question_type": "Allocation and assessment", "question": "Are the design, concealment, and blinding of the monotherapy comparison known?", "needed": "Actual design, allocation/concealment, baseline balance, and assessment procedures", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid using a triple-blind label from a related study as a direct B5 bias assessment.", "application_exception": "Do not mark crossover or cluster designs as not applicable when the design is unverified.", "criterion": "Link the actual design/assessment information and limitations of the directly selected results.", "basis": "M08 §8.1–8.2.3; internal application; M08 Table 8.2.a, M03 §3.2.4; internal application; M03 §3.2.1; detailed population conditions are internally designed", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Obtain monotherapy methods, registration, and baseline/assessment materials and review them at the outcome level.", "current_reports": [ "S101", "S102" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The related Evans pantethine study is a triple-blind trial, but the directly relevant design, allocation, concealment, and blinding for B5 monotherapy are unverified.", "condition_status": "Unverified", "status_reason": "Do not label this as formal execution of RoB 2 or absence of bias.", "missingness": "Do not label this as formal execution of RoB 2 or absence of bias.", "uncertainty": "Do not label this as formal execution of RoB 2 or absence of bias.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Actual design, allocation/concealment, baseline balance, and assessment procedures" }, { "item_id": "N15", "question_type": "Adherence and discontinuation", "question": "Are adherence, rescue treatment, analysis populations, and missing-data handling known?", "needed": "Actual intake, discontinuation, arm-specific changes, ITT/PP, and missing-data handling", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid mixing the effect of assignment with before-and-after effects among adherent participants/completers.", "application_exception": "Do not arbitrarily fill in analysis methods absent from the original text.", "criterion": "Distinguish directly eligible information on adherence, withdrawals, and analysis from what remains unverified.", "basis": "M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M08 §8.2.2, M15 §15.3.1; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; adaptations by study design are this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the analysis plan, administration records, and participant flow against the results tables to examine their impact.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Adherence to the single-active-ingredient product, withdrawals by arm, analysis populations, and handling of missing data are unverified.", "condition_status": "Unverified", "status_reason": "Pantethine allocation/completion counts alone do not reveal how the selected results were handled.", "missingness": "Pantethine allocation/completion counts alone do not reveal how the selected results were handled.", "uncertainty": "Pantethine allocation/completion counts alone do not reveal how the selected results were handled.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Actual intake, discontinuation, arm-specific changes, ITT/PP, and missing-data handling" }, { "item_id": "N16", "question_type": "Precision and importance", "question": "What magnitudes of difference does the reported interval allow?", "needed": "Direct effect/CI, variance, and a justified important difference", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid declaring sufficiency based only on sample size, statistical significance, or the number of trials.", "application_exception": "Do not arbitrarily adopt a common minimum sample size, duration, or MCID.", "criterion": "Explain the relationship between the reported interval and the importance criterion, or why it cannot be interpreted.", "basis": "M15 §15.3.1–15.3.3; own application; M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; adaptations by study design are this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Obtain the basis for importance appropriate to the endpoint/population and the actual reported interval separately, and compare them.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The direct LDL-C CI, variance, and important-difference criterion are unverified, and the original precision axis is an unscored empty value.", "condition_status": "Unverified", "status_reason": "Do not use an unverified interval to exclude an important effect or create a new grade.", "missingness": "Do not use an unverified interval to exclude an important effect or create a new grade.", "uncertainty": "Do not use an unverified interval to exclude an important effect or create a new grade.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Direct effect/CI, variance, and a justified important difference" }, { "item_id": "N17", "question_type": "Positive adjacent results", "question": "What produced the LDL-C improvement in Evans?", "needed": "Actual ingredients, within-arm changes, time points, and original tables from the pantethine trial", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to preserve attribution to a different molecule without concealing favorable results.", "application_exception": "Do not calculate a new between-group effect from the two changes from baseline.", "criterion": "Explain the measure, duration, and substance in the positive report together with the reason for its direct ineligibility.", "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is this project's own design; M03 §3.2.2–3.2.3; reverse-direction labeling and adaptations for tests are this project's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design; M04 §4.6.1–4.6.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the original LDL-C tables against the product/analysis documents to verify the scope of the reported values.", "current_reports": [ "S101", "S102" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "In Evans, the 16-week pantethine-arm -11% and placebo-arm +3% are changes from each arm's baseline. The positive pantethine results were preserved but were not attributed to an effect of pantothenic acid as the sole active ingredient.", "condition_status": "Partly verified", "status_reason": "The complete original results tables and a single-active-ingredient B5 estimate are unverified in this review.", "missingness": "The complete original results tables and a single-active-ingredient B5 estimate are unverified in this review.", "uncertainty": "The complete original results tables and a single-active-ingredient B5 estimate are unverified in this review.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Actual ingredients, within-arm changes, time points, and original tables from the pantethine trial" }, { "item_id": "N18", "question_type": "Different P tests", "question": "Are P=0.006 and P=0.010 the same comparison?", "needed": "Concentration comparison, percentage-change comparison, actual analysis, and time points", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid merging distinct reported tests into one.", "application_exception": "Do not convert a P value into an effect size or CI.", "criterion": "Preserve the P values for the comparisons distinguished in the original text, their attribution, and the unverified aspects.", "basis": "M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is this project's own design; M08 §8.2.2, M15 §15.3.1; own application; M15 §15.3.1–15.3.3; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the concentration/percentage results tables and the analysis plan to verify the definition and denominator of each test.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The between-group concentration comparison P=0.006 and the percentage-change comparison P=0.010 were preserved as distinct reported values from Evans's pantethine study.", "condition_status": "Partly verified", "status_reason": "The direct B5 P value is empty, and the detailed analyses for the two tests were not newly verified.", "missingness": "The direct B5 P value is empty, and the detailed analyses for the two tests were not newly verified.", "uncertainty": "The direct B5 P value is empty, and the detailed analyses for the two tests were not newly verified.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Concentration comparison, percentage-change comparison, actual analysis, and time points" }, { "item_id": "N19", "question_type": "Adjacent-study denominators", "question": "What do 32 allocated and 24 completed mean?", "needed": "Evans allocation, completion, analyses by arm/endpoint, and reasons for dropout", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid treating the overall allocation/completion counts as the same analysis denominator.", "application_exception": "Do not calculate new arm-specific dropout counts or rates from the difference.", "criterion": "Preserve the related trial's original denominators and explain the unverified aspects of the direct/arm-specific analyses.", "basis": "M08 Table 8.2.a, M15 §15.3, M19 §19.1.2–19.2.4; adaptations by study design are this project's own design; M08 §8.2.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Link Evans's participant flow with the outcome-specific analysis tables to review the denominators.", "current_reports": [ "S101", "S102" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Evans was recorded as having 32 randomized and 24 completed. This information belongs to the pantethine trial and is not used as a direct B5 denominator.", "condition_status": "Partly verified", "status_reason": "Arm-specific LDL-C analysis denominators and the reasons for and handling of dropouts are unverified in the preserved text.", "missingness": "Arm-specific LDL-C analysis denominators and the reasons for and handling of dropouts are unverified in the preserved text.", "uncertainty": "Arm-specific LDL-C analysis denominators and the reasons for and handling of dropouts are unverified in the preserved text.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Evans allocation, completion, analyses by arm/endpoint, and reasons for dropout" }, { "item_id": "N20", "question_type": "Reports of the same trial", "question": "Are PMC and PubMed independent replication trials?", "needed": "S101/S102 DOI, PMID, trial, and outcome linkage", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid counting reports as unique trials.", "application_exception": "Do not automatically establish that other references concern the same cohort or independent trials.", "criterion": "Distinguish verified links between reports of the same study from unresolved families.", "basis": "Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is an own application; M04 §4.6.1–4.6.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Track registration, recruitment, participant, and trial identifiers across reports to check for overlap.", "current_reports": [ "S101", "S102", "L366-1", "L366-2", "L366-3" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "S101 PMC and S102 PubMed have the same DOI10.2147/VHRM.S57116 and PMID24600231 and refer to the Evans2014 trial. They were not counted as two independent replications.", "condition_status": "Partly verified", "status_reason": "Participant links with the other pantethine references were not verified in these materials.", "missingness": "Participant links with the other pantethine references were not verified in these materials.", "uncertainty": "Participant links with the other pantethine references were not verified in these materials.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "S101/S102 DOI, PMID, trial, and outcome linkage" }, { "item_id": "N21", "question_type": "Funding and independence", "question": "Were Evans's funding and independent replication verified?", "needed": "Reported funding, product/author relationships, institutions, and family linkage", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid turning original funding reports into independent funding or absence of bias.", "application_exception": "Do not automatically exclude results because funding was provided.", "criterion": "Explain the verified funding and the scope of unverified disclosures/independence.", "basis": "Chamgap's own conditions for independence and attribution. The official methods sections used in this pilot do not guarantee all of these detailed items; distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is an own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Separately compare paper disclosures, product provision, author/institutional relationships, and study families.", "current_reports": [ "S101", "S102" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The Evans pantethine trial was recorded as funded by Daiichi Fine Chemical Co Ltd.", "condition_status": "Partly verified", "status_reason": "This information belongs to pantethine and does not establish independent funding for direct B5 evidence or all conflicts of interest.", "missingness": "This information belongs to pantethine and does not establish independent funding for direct B5 evidence or all conflicts of interest.", "uncertainty": "This information belongs to pantethine and does not establish independent funding for direct B5 evidence or all conflicts of interest.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Reported funding, product/author relationships, institutions, and family linkage" }, { "item_id": "N22", "question_type": "Nonhuman mechanisms", "question": "Do mouse/adipocyte results answer the question about human LDL-C?", "needed": "Species, sex, experimental system, measured endpoints, and whether a human comparison exists", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid transferring mechanistic observations to a human lipid effect of a single active ingredient.", "application_exception": "Preserve nonhuman studies within their scope without deleting them.", "criterion": "Explain the difference between the actual nonhuman subjects and the direct human question.", "basis": "M03 §3.2.1; detailed population conditions are this project's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design; M03 §3.2.4; own boundary on extensions", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare, for each material, the differences between the experimental endpoints and the human intervention, population, and LDL-C estimand.", "current_reports": [ "S103", "S104" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Zhao is a mechanistic study of adult male mice and primary adipocytes. It was not repurposed as a controlled human LDL-C trial of a single active ingredient.", "condition_status": "Partly verified", "status_reason": "The material read in this review is a preserved abstract/structured summary, and the full text of the original nonhuman results was not read.", "missingness": "The material read in this review is a preserved abstract/structured summary, and the full text of the original nonhuman results was not read.", "uncertainty": "The material read in this review is a preserved abstract/structured summary, and the full text of the original nonhuman results was not read.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Species, sex, experimental system, measured endpoints, and whether a human comparison exists" }, { "item_id": "N23", "question_type": "Possible preprint", "question": "Are S103 and S104 the same study?", "needed": "Relationships among the preprint/paper, authors, experiments, and versions", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid summing a possibly related preprint as an independent replication.", "application_exception": "Do not establish that studies are identical solely from similar titles.", "criterion": "Distinguish the preserved possible relationship, verified identifiers, and remaining gaps.", "basis": "Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is an own application; data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M04 §4.6.1–4.6.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Check correspondence among versions, authors, experiments, and data, and record whether they belong to the same or different families.", "current_reports": [ "S103", "S104" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "S104 is a search-title/author/DOI lead, with no results extracted. It remains a possible related preprint of S103, and the exact relationship is unverified.", "condition_status": "Unverified", "status_reason": "S104 was not counted as a new independent human trial or a verified nonhuman replication.", "missingness": "S104 was not counted as a new independent human trial or a verified nonhuman replication.", "uncertainty": "S104 was not counted as a new independent human trial or a verified nonhuman replication.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Relationships among the preprint/paper, authors, experiments, and versions" }, { "item_id": "N24", "question_type": "Combination-product protocol", "question": "Is the NCT03444155 protocol a single-active-ingredient B5 result?", "needed": "Protocol version, combination composition, comparator, administration plan, and actual results", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to distinguish plans from results and contributions within a combination.", "application_exception": "A record of protocol access does not verify actual allocation or results.", "criterion": "Explain the attribution of the actual combination protocol and the unverified single-active-ingredient results.", "basis": "M03 §3.2.2–3.2.3; reverse-direction labeling and adaptations for tests are this project's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design; M03 §3.2.3, M08 §8.2.2–8.2.3; own application; M08 Table 8.2.a, M04 §4.6.3; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the planned composition, results/registration, and analysis plan to examine actual conduct and the contribution of the single ingredient.", "current_reports": [ "S105", "S106" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "S105 is a natural versus synthetic B-complex protocol, v1.2/2017-04-13. The actual number randomized and single-active-ingredient LDL-C results are unverified.", "condition_status": "Partly verified", "status_reason": "The multicomponent protocol and registration were not counted as eligible single-active-ingredient trials.", "missingness": "The multicomponent protocol and registration were not counted as eligible single-active-ingredient trials.", "uncertainty": "The multicomponent protocol and registration were not counted as eligible single-active-ingredient trials.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Protocol version, combination composition, comparator, administration plan, and actual results" }, { "item_id": "N25", "question_type": "Registration and selective reporting", "question": "Were the planned endpoint and reporting for the selected LDL-C outcome compared?", "needed": "Directly eligible registration, protocol, SAP, and actual reporting/changes", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to identify the material required to check whether only favorable analyses were selected.", "application_exception": "Do not turn failure to acquire material into confirmation of nonregistration or selective reporting.", "criterion": "Indicate the actual scope of plan/report comparison for the direct comparison and the aspects not compared.", "basis": "Data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M04 §4.5, §4.6.3; limitations of the current material conversion follow the user's scope and this project's own design; M08 Table 8.2.a, M04 §4.6.3; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Review the direct trial by linking registration, plans, reporting time points/analyses, and reasons for changes.", "current_reports": [ "S105", "S106" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Comparison of plans and reports for single-active-ingredient B5 LDL-C outcomes is unverified. S106 is a historical record that only a landing shell was returned; it does not mean that current recruitment/results or the complete outcome hierarchy were read.", "condition_status": "Unverified", "status_reason": "Do not assess selective reporting for the direct single-active-ingredient question from partial reading of the combination S105 protocol.", "missingness": "Do not assess selective reporting for the direct single-active-ingredient question from partial reading of the combination S105 protocol.", "uncertainty": "Do not assess selective reporting for the direct single-active-ingredient question from partial reading of the combination S105 protocol.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Directly eligible registration, protocol, SAP, and actual reporting/changes" }, { "item_id": "N26", "question_type": "Earlier pantethine references", "question": "Are the three references from the previous 366 direct B5 replications?", "needed": "Gaddi/Rumberger original trials, McRae review, molecules, and included study families", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid summing earlier references, reviews, and trials as independent single-active-ingredient B5 replications.", "application_exception": "Do not carry over the previous C and 52 points to the new question.", "criterion": "Distinguish each material type, molecule, and unverified results/families.", "basis": "Distinction between studies and reports in M04 §4.6.1–4.6.2; cohort/outcome linkage is an own application; data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M04 §4.6.1–4.6.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare the identities of the original trials, review inclusion tables, and related reports to check overlap and population differences.", "current_reports": [ "L366-1", "L366-2", "L366-3" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "L366-1 Gaddi1984 and L366-3 Rumberger2011 are pantethine trial references, and L366-2 McRae2005 is a pantethine review. What was read in the current review is the inherited_local_citation preserved in 3100.", "condition_status": "Partly verified", "status_reason": "The earlier original files, external paper results, and cohort links with Evans were not read/are unverified in this review.", "missingness": "The earlier original files, external paper results, and cohort links with Evans were not read/are unverified in this review.", "uncertainty": "The earlier original files, external paper results, and cohort links with Evans were not read/are unverified in this review.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Gaddi/Rumberger original trials, McRae review, molecules, and included study families" }, { "item_id": "N27", "question_type": "Earlier different questions", "question": "Are skin 028 and acne 3099 LDL-C results?", "needed": "Identity, endpoints, and linkage of the earlier composite skin/hair and acne questions", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid merging different outcomes for the same ingredient into this efficacy question.", "application_exception": "Reading the reference records in 3100 differs from directly reading the earlier original files.", "criterion": "Preserve the differences between the original related questions and the selected LDL-C endpoint, and the reading gaps.", "basis": "Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are this project's own design; data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Compare differences in the identities, endpoints, and composition of the related original texts to the extent needed.", "current_reports": [ "L028", "L3099" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "L028 is a historical composite skin/hair record, and L3099 is a reference to the inflammatory acne question. They were not combined as direct results for the LDL-C question.", "condition_status": "Partly verified", "status_reason": "The referenced legacy files were not read in this review. The L3099 bibliographic URL is empty; do not invent successful original-text reading or a server URL from that time.", "missingness": "The referenced legacy files were not read in this review. The L3099 bibliographic URL is empty; do not invent successful original-text reading or a server URL from that time.", "uncertainty": "The referenced legacy files were not read in this review. The L3099 bibliographic URL is empty; do not invent successful original-text reading or a server URL from that time.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Identity, endpoints, and linkage of the earlier composite skin/hair and acne questions" }, { "item_id": "N28", "question_type": "Mixed-product and search leads", "question": "What is the scope of the S107/S108/S109 materials?", "needed": "Article identifiers, product composition, concentration/oxidative stability, and guideline full texts", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid turning search titles, access failures, and domain addresses into direct clinical results.", "application_exception": "Do not count inaccessible materials as negative trials.", "criterion": "Explain each lead's material type, different question, and unverified results.", "basis": "Data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M03 §3.2.4, M15 §15.3.1–15.3.3; question-specific outcome adaptations are this project's own design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is this project's own design; M04 §4.5, §4.6.3; limitations of the current material conversion follow the user's scope and this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Verify article identity, product/endpoints, and original text to review eligibility for the direct question and the level of results.", "current_reports": [ "S107", "S108", "S109" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "S107 is a fortified margarine+B6 title and J-STAGE domain lead. S108 is a mixed-product/LDL oxidative-stability lead with an access failure at that time; S109 is a 2026 guideline domain lead, from which no B5 recommendation was extracted.", "condition_status": "Partly verified", "status_reason": "The existence of a lead does not verify individual results or current guideline content.", "missingness": "The existence of a lead does not verify individual results or current guideline content.", "uncertainty": "The existence of a lead does not verify individual results or current guideline content.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Article identifiers, product composition, concentration/oxidative stability, and guideline full texts" }, { "item_id": "N29", "question_type": "Scope of contrary findings and absence", "question": "Does an unverified direct result mean an effect of 0 or worldwide absence?", "needed": "Verified direct/adjacent and positive/other results, and search scope/failures", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid extending the finding to no effect, refutation, or absence of all studies worldwide.", "application_exception": "Do not turn access failures and incomplete searching into negative studies or 0 studies.", "criterion": "Explain attribution of all verified results and the limited scope of unverified direct evidence.", "basis": "M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is this project's own design; M04 §4.5, §4.6.3; limitations of the current material conversion follow the user's scope and this project's own design; M04 §4.6.1–4.6.2, M15 §15.3.1; own application", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "In an authorized update, recompare search records, missing materials, and the reasons for each eligibility decision.", "current_reports": [ "S101", "S103", "S105", "S107", "S108" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Positive pantethine results and nonhuman/combination/lead materials were preserved. Unverified directly eligible single-active-ingredient B5 results were not turned into repeated refutation, an effect of 0, or worldwide absence.", "condition_status": "Met", "status_reason": "The original no_human_study=true/human_study_exists=false applies to the fixed directly eligible question scope, and related_human_studies_exist=true is also preserved.", "missingness": "The original no_human_study=true/human_study_exists=false applies to the fixed directly eligible question scope, and related_human_studies_exist=true is also preserved.", "uncertainty": "The original no_human_study=true/human_study_exists=false applies to the fixed directly eligible question scope, and related_human_studies_exist=true is also preserved.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Verified direct/adjacent and positive/other results, and search scope/failures" }, { "item_id": "N30", "question_type": "Materials and reading", "question": "Were current summaries distinguished from historical full-text access?", "needed": "Publication, attempted/successful access, acquisition, reading, and actual dates and locations for each material", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid turning historical access_level into original-paper reading in this review.", "application_exception": "Do not label unattempted access as failed access or infer access dates from the overall review date.", "criterion": "Link the preserved locations actually read in the current review with each referenced material's unread status/historical record.", "basis": "Data collection/selection principles in M04 §4.5–4.6; separation of access and reading and the hyperlink contract are this project's own design; M04 §4.5, §4.6.3; limitations of the current material conversion follow the user's scope and this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Record the original identity, access/acquisition, actual locations read, and dates separately for each material.", "current_reports": [ "S06", "S101", "S102", "S103", "S104", "S105", "S106", "L366-1", "L366-2", "L366-3", "L028", "L3099", "S107", "S108", "S109" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "This review read the complete preserved archived summary of 3100 and the exact bibliographic/linkage summaries. The historical full_text for S101/S105 and the S06 inherited extraction, abstract/index/shell/access_failed/local_original are preserved separately, and the linked original materials were not read in this review.", "condition_status": "Met", "status_reason": "The original historical full-text bytes, current file SHA, and actual access dates at that time are unverified. The original 2026-09-15 review date was not copied into individual material access dates.", "missingness": "The original historical full-text bytes, current file SHA, and actual access dates at that time are unverified. The original 2026-09-15 review date was not copied into individual material access dates.", "uncertainty": "The original historical full-text bytes, current file SHA, and actual access dates at that time are unverified. The original 2026-09-15 review date was not copied into individual material access dates.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Publication, attempted/successful access, acquisition, reading, and actual dates and locations for each material" }, { "item_id": "N31", "question_type": "Preservation of the original judgment", "question": "Are the original grade, score, and axes new condition statuses?", "needed": "Original ?, empty values, B/S, unscored subsequent axes/strength, and gate/original calculation", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid elevating an earlier score or an absence gate into a new judgment.", "application_exception": "The conditional record of the original C cap is also not an application or a new calculation in this review.", "criterion": "Preserve the original judgment values as quotations and distinguish them from conditions being met in the new table.", "basis": "Question-clarification principles in M03 §3.1, §3.2.1–3.2.4; detailed separation rules are this project's own design; M04 §4.6.3, M15 §15.3.1–15.3.3; separation of statuses is this project's own design; M04 §4.5, §4.6.3; limitations of the current material conversion follow the user's scope and this project's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "In a separately authorized update, record the original calculation inputs/rules and reasons for changes, while preserving the original and its versions.", "current_reports": [], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The original ?, empty score, B/S, empty values for the last 5 axes, unscored strengths, empty numerical/denominator fields in primary_effect, and the direct-eligibility gate/related human data were preserved. Pantethine C/52 and the skin composite C were not inherited.", "condition_status": "Met", "status_reason": "No new efficacy grade, score, probability, or clinical calculation was produced.", "missingness": "No new efficacy grade, score, probability, or clinical calculation was produced.", "uncertainty": "No new efficacy grade, score, probability, or clinical calculation was produced.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Original ?, empty values, B/S, unscored subsequent axes/strength, and gate/original calculation" }, { "item_id": "N32", "question_type": "Extension to clinical events", "question": "Does an LDL-C difference answer questions about cardiovascular events or medication replacement?", "needed": "Boundary between the selected laboratory result and questions about events/treatment replacement", "role": "Supplementary (boundary for extension to clinical events)", "role_reason": "Needed to prevent automatic extension from a surrogate marker to prevention of clinical events.", "application_exception": "An event trial is not imposed as an additional requirement for the LDL-C concentration question itself.", "criterion": "Distinguish the original question from a separate extension to clinical events.", "basis": "M03 §3.2.4; extension boundary specified by the author", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Review direct clinical comparisons for a separate question that makes a claim about events or treatment replacement.", "current_reports": [ "S101", "S103", "S105" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "This table concerns LDL-C concentration. Cardiovascular-event reduction and replacement of lipid medications were not imposed as additional requirements for the original question; they remain extensions requiring separate direct evidence.", "condition_status": "Not applicable", "status_reason": "This nonapplicability does not substitute for unverified direct LDL-C data.", "missingness": "This nonapplicability does not substitute for unverified direct LDL-C data.", "uncertainty": "This nonapplicability does not substitute for unverified direct LDL-C data.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Boundary between the selected laboratory result and questions about events/treatment replacement" }, { "item_id": "N33", "question_type": "Extensions to dose and persistence", "question": "Does the evidence answer questions about optimal dose, persistence after discontinuation, and all subgroups?", "needed": "Direct dose comparisons, discontinuation/long-term follow-up, and prespecified subgroups/interactions", "role": "Supplementary (extensions to dose, persistence, and populations)", "role_reason": "Needed to prevent extension of the narrow concentration question to optimal dose, persistence, or efficacy in all populations.", "application_exception": "Extension studies are not imposed as requirements for the current question as a whole.", "criterion": "Separately distinguish extensions to dose/persistence and populations that are absent from direct comparisons.", "basis": "M03 §3.2.1–3.2.4; details on dose, persistence, and effect modification use the author's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Link comparisons and outcomes appropriate to separate dose, follow-up, and effect-modification questions to the planned/actual analyses.", "current_reports": [ "S101" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The current concentration comparison alone does not verify optimal dose, persistence after discontinuation, or effects in all subgroups, and these extensions were not imposed as additional requirements for the original question.", "condition_status": "Not applicable", "status_reason": "Gaps in directly eligible dose, duration, and population remain unchanged in their corresponding rows.", "missingness": "Gaps in directly eligible dose, duration, and population remain unchanged in their corresponding rows.", "uncertainty": "Gaps in directly eligible dose, duration, and population remain unchanged in their corresponding rows.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Direct dose comparisons, discontinuation/long-term follow-up, and prespecified subgroups/interactions" }, { "item_id": "N34", "question_type": "General harms and nutrition", "question": "Do high-dose harms and nutritional reference values establish a lipid-treatment dose?", "needed": "Harms involving the same ingredient, exposure, denominator/duration, collection, and nutritional reference values", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to prevent general descriptions of harms from being converted into incidence rates, treatment doses, or confirmation of overall safety.", "application_exception": "The 10 g/day example is not a toxicity threshold/recommendation, and 5 mg/day is the adult adequate intake.", "criterion": "Distinguish the original harm/nutrition descriptions from gaps in safety evidence from direct comparisons.", "basis": "M19 §19.1.2–19.2.4; the author's own application; M19 §19.1.2–19.2.4; detailed distinctions use the author's own design; Chamgap's own interpretive boundary. The principles of M19 are referenced; this is not an application of a formal causality tool", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Separately verify harm collection matched to the exposure, arm-specific events/discontinuations, and denominator/duration data.", "current_reports": [ "S06" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The original Caution label and high-dose diarrhea/gastrointestinal discomfort were preserved. NIH's 10 g/day example and the adult adequate intake of 5 mg/day are not lipid-treatment doses or toxicity thresholds. The absence of an established upper limit does not mean unlimited safety.", "condition_status": "Partly verified", "status_reason": "Arm-specific events/discontinuations and denominators/durations in a direct LDL-C monotherapy trial are unverified, and pantethine bleeding/anticoagulation cautions were not copied to B5.", "missingness": "Arm-specific events/discontinuations and denominators/durations in a direct LDL-C monotherapy trial are unverified, and pantethine bleeding/anticoagulation cautions were not copied to B5.", "uncertainty": "Arm-specific events/discontinuations and denominators/durations in a direct LDL-C monotherapy trial are unverified, and pantethine bleeding/anticoagulation cautions were not copied to B5.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Harms involving the same ingredient, exposure, denominator/duration, collection, and nutritional reference values" }, { "item_id": "N35", "question_type": "Long-term use and vulnerable populations", "question": "Has safety been verified for long-term high-dose use, concomitant use, and vulnerable populations?", "needed": "Long-term use for LDL-C, pregnancy/lactation, children, liver/kidney disease, and concomitant use", "role": "Supplementary (extension to long-term/concomitant-use safety)", "role_reason": "Needed to prevent limited general records from being extended to safety in all populations/combinations.", "application_exception": "No known important interactions does not mean that all interactions have been excluded.", "criterion": "Indicate the limits of direct safety evidence for the selected purpose and gaps in populations/durations.", "basis": "Design considerations in M19 §19.2.2–19.2.4; detailed confounding records use the author's own design; M19 §19.1.2–19.2.4; the author's own application; Chamgap's own interpretive boundary. The principles of M19 are referenced; this is not an application of a formal causality tool", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "Review studies of harms from long-term use, use in special populations, and concomitant use with matching exposure/baseline risk and appropriate collection methods.", "current_reports": [ "S06" ], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "Safety for long-term high-dose use for LDL-C, pregnancy/lactation, children, and liver/kidney disease is unverified. The interaction description was not used as proof of safety for all combinations.", "condition_status": "Unverified", "status_reason": "Do not convert research or nutritional values into personal dosing instructions.", "missingness": "Do not convert research or nutritional values into personal dosing instructions.", "uncertainty": "Do not convert research or nutritional values into personal dosing instructions.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Long-term use for LDL-C, pregnancy/lactation, children, liver/kidney disease, and concomitant use" }, { "item_id": "N36", "question_type": "Reference date and updates", "question": "What can change, as of which date and within which scope?", "needed": "Original evidence/review dates, actual current review, search scope, and new data/corrections/retractions", "role": "Required (selected B5 monotherapy and LDL-C comparison)", "role_reason": "Needed to avoid overstating this conversion as a current comprehensive search, publication, or independent clinical certification.", "application_exception": "first_published_at is an editorial reference date, not proof of actual server publication.", "criterion": "Separate the original dates and review/access levels from activities not currently performed and the conditions for updates.", "basis": "M04 §4.5, §4.6.3; the limits of the current data conversion follow the user's scope and the author's own design; data collection/selection principles in M04 §4.5–4.6; the separation of access from reading and the hyperlink contract use the author's own design; M04 §4.6.3, M15 §15.3.1–15.3.3; status distinctions use the author's own design", "condition_origin": "Individual development conditions designed with knowledge of all retained 3100 material; not blinded, clinically preregistered, or independently certified", "proposed_research": "In a separately authorized update, preserve the identity of new material, its full original text, and the before/after values, and review the linked conditions again.", "current_reports": [], "existence": "Current retained bibliography/linked summaries and historical records exist; current external verifications 0", "acquired_read": "The complete, exactly retained archived summary was actually read; the linked original material was not read in this review", "observation": "The evidence/original review date is 2026-09-15, and this conversion is not a new clinical search, external full-text reading, calculation, regrading, or deployment. If new monotherapy trials, salts/products, LDL-C tables/denominators/SAP, corrections/retractions, or classification/numerical errors are verified, preserve the same ID/URL and the prior original text/history.", "condition_status": "Met", "status_reason": "The original document_quality B, grade_revalidated, and self-review are original reports. They are not independent clinical/academic certification of the current table.", "missingness": "The original document_quality B, grade_revalidated, and self-review are original reports. They are not independent clinical/academic certification of the current table.", "uncertainty": "The original document_quality B, grade_revalidated, and self-review are original reports. They are not independent clinical/academic certification of the current table.", "review_date": "2026-10-05", "reading_status": "Original material not read · Archived summary read", "additional_material": "Original evidence/review dates, actual current review, search scope, and new data/corrections/retractions" } ], "reports": [ { "report_id": "S06", "title": "NIH Office of Dietary Supplements. Pantothenic Acid — Health Professional Fact Sheet", "url": "https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/", "report_type": "NIH nutrition and safety document", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Official_nutrition_safety", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Description of nutritional reference values, high-dose GI effects, absence of an established upper limit, and interactions; not an LDL-C monotherapy trial", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S06-M1", "url": null, "parent_url": null }, { "material_type": "Official web document", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: inherited_full_text_extraction. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Table 1; Dietary supplements; Health Risks from Excessive Pantothenic Acid; Interactions with Medications", "material_id": "S06-M2", "url": "https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://ods.od.nih.gov/factsheets/PantothenicAcid-HealthProfessional/" } ] }, { "report_id": "S101", "title": "Evans et al. 2014. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3942300/", "report_type": "Evans2014 PMC original-article bibliography", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F101", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Pantethine 16 weeks · 32 randomized/24 completed · within-arm -11%/+3% · P0.006/0.010; ineligible as direct B5 evidence", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S101-M1", "url": null, "parent_url": null }, { "material_type": "PMC full-text page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: full_text. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Abstract; Methods: study design, inclusion criteria and primary endpoint; Results and Figures 2–3; Acknowledgments; Disclosure", "material_id": "S101-M2", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3942300/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3942300/" } ] }, { "report_id": "S102", "title": "PubMed record for Evans et al. 2014", "url": "https://pubmed.ncbi.nlm.nih.gov/24600231/", "report_type": "Bibliography/abstract for the same Evans study in PubMed", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F101", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "The same trial as S101, with the same DOI/PMID; not a separate replication", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S102-M1", "url": null, "parent_url": null }, { "material_type": "PubMed bibliography/abstract", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: abstract. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Bibliography and abstract", "material_id": "S102-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/24600231/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/24600231/" } ] }, { "report_id": "S103", "title": "Zhao et al. Pantothenic Acid Alleviates Fat Deposition and Inflammation by Suppressing the JNK/P38 MAPK Signaling Pathway", "url": "https://pubmed.ncbi.nlm.nih.gov/38949913/", "report_type": "Bibliography/abstract for the nonhuman Zhao paper", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F102_Preprint_linkage_unverified", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Mechanism in adult male mice/primary adipocytes; not attributed to human LDL-C", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S103-M1", "url": null, "parent_url": null }, { "material_type": "PubMed bibliography/abstract", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: abstract. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Abstract: adult male mice and primary adipocytes; journal/date/DOI", "material_id": "S103-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/38949913/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/38949913/" } ] }, { "report_id": "S104", "title": "Preprint lead: Pantothenic acid alleviates fat deposition by preventing activation of the JNK/P38 MAPK pathway", "url": "https://doi.org/10.21203/rs.3.rs-3412435/v1", "report_type": "Search bibliography for a possibly related preprint", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F102_Preprint_linkage_unverified", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Title/author/DOI leads only; results/exact version linkage unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S104-M1", "url": null, "parent_url": null }, { "material_type": "Preprint DOI page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: metadata_search_index. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Search title/author/DOI discovery only; no preprint results extracted", "material_id": "S104-M2", "url": "https://doi.org/10.21203/rs.3.rs-3412435/v1", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://doi.org/10.21203/rs.3.rs-3412435/v1" } ] }, { "report_id": "S105", "title": "NCT03444155 protocol and statistical plan, version 1.2 dated 2017-04-13: natural versus synthetic vitamin B complex", "url": "https://cdn.clinicaltrials.gov/large-docs/55/NCT03444155/Prot_SAP_000.pdf", "report_type": "Bibliography for the B-complex protocol", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F103", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "v1.2/2017-04-13 · composition/administration plan; monotherapy results/actual randomization unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S105-M1", "url": null, "parent_url": null }, { "material_type": "Protocol/SAP PDF", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: full_text. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Protocol v1.2, 2017-04-13; printed pp. 5–6: multivitamin formulations and dosing plan. PDF pages 4 and 5 also inspected as screenshots.", "material_id": "S105-M2", "url": "https://cdn.clinicaltrials.gov/large-docs/55/NCT03444155/Prot_SAP_000.pdf", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://cdn.clinicaltrials.gov/large-docs/55/NCT03444155/Prot_SAP_000.pdf" } ] }, { "report_id": "S106", "title": "ClinicalTrials.gov landing page for NCT03444155", "url": "https://clinicaltrials.gov/study/NCT03444155", "report_type": "Bibliography for the same NCT registry landing page", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "F103", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Only a shell at the time; current recruitment/results/complete outcomes unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S106-M1", "url": null, "parent_url": null }, { "material_type": "ClinicalTrials.gov registry page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: metadata_shell. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Only the landing shell was returned. Current recruitment/results/complete outcome hierarchy not read.", "material_id": "S106-M2", "url": "https://clinicaltrials.gov/study/NCT03444155", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://clinicaltrials.gov/study/NCT03444155" } ] }, { "report_id": "L366-1", "title": "Gaddi A, Descovich GC, Noseda G, et al. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipidemia. Atherosclerosis. 1984;50(1):73-83. PMID: 6365107. DOI: 10.1016/0021-9150(84)90009-1.", "url": "https://pubmed.ncbi.nlm.nih.gov/6365107/", "report_type": "Gaddi1984 previous pantethine bibliography", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Previous_pantethine_family_unverified", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Currently preserved as a legacy366 inherited citation; results/family relationships unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "L366-1-M1", "url": null, "parent_url": null }, { "material_type": "PubMed bibliographic page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: inherited_local_citation. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: reference/legacy_366.json /citations/0; corresponding evidence row", "material_id": "L366-1-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/6365107/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/6365107/" } ] }, { "report_id": "L366-2", "title": "McRae MP. Treatment of hyperlipoproteinemia with pantethine: a review and analysis of efficacy and tolerability. Nutr Res. 2005;25(4):319-333. DOI: 10.1016/j.nutres.2004.12.009.", "url": "https://doi.org/10.1016/j.nutres.2004.12.009", "report_type": "McRae2005 previous pantethine-review bibliography", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Previous_pantethine_review", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Review ≠ B5 monotherapy trial; included studies/overlap unverified in this review", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "L366-2-M1", "url": null, "parent_url": null }, { "material_type": "Review DOI page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: inherited_local_citation. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: reference/legacy_366.json /citations/1; corresponding evidence row", "material_id": "L366-2-M2", "url": "https://doi.org/10.1016/j.nutres.2004.12.009", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://doi.org/10.1016/j.nutres.2004.12.009" } ] }, { "report_id": "L366-3", "title": "Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M. Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation. Nutr Res. 2011;31(8):608-615. PMID: 21925346. DOI: 10.1016/j.nutres.2011.08.001.", "url": "https://pubmed.ncbi.nlm.nih.gov/21925346/", "report_type": "Rumberger2011 previous pantethine bibliography", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Previous_pantethine_family_unverified", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Currently preserved as a legacy366 inherited citation; relationship to the Evans cohort unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "L366-3-M1", "url": null, "parent_url": null }, { "material_type": "PubMed bibliographic page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: inherited_local_citation. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: reference/legacy_366.json /citations/2; corresponding evidence row", "material_id": "L366-3-M2", "url": "https://pubmed.ncbi.nlm.nih.gov/21925346/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://pubmed.ncbi.nlm.nih.gov/21925346/" } ] }, { "report_id": "L028", "title": "Legacy 028: pantothenic acid × skin/hair, historical composite", "url": "/verdicts/skin-hair/pantothenic-skin/", "report_type": "Reference to a previous composite skin/hair record", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Different_skin_hair_composite_question", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "A different question from LDL-C; the referenced legacy file was not read in this review", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "L028-M1", "url": null, "parent_url": null }, { "material_type": "Reference material from previous work", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: local_original. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: reference/legacy_028.json; inherited prior R01-021 extraction; no new skin/hair investigation", "material_id": "L028-M2", "url": "/verdicts/skin-hair/pantothenic-skin/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://chamgap.com/verdicts/skin-hair/pantothenic-skin/" } ] }, { "report_id": "L3099", "title": "Completed R01-021: oral pantothenic acid monotherapy × inflammatory acne lesions", "url": null, "report_type": "Reference to the previous 3099 acne record", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Different_acne_question", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Inflammatory lesions ≠ LDL-C; empty URL in the preserved bibliography/server URL unverified at the time", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "L3099-M1", "url": null, "parent_url": null }, { "material_type": "Reference material from previous work", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: local_original. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: reference/reused_TASK0021.json; ID 3099 is supplied by the user, no server URL verified", "material_id": "L3099-M2", "url": null, "parent_url": null } ], "links": [] }, { "report_id": "S107", "title": "Discovery lead: Influence of Several Lipids on Human Serum Cholesterol (Part 9), enriched margarine with pantothenic acid and vitamin B6", "url": "https://www.jstage.jst.go.jp/", "report_type": "Fortified margarine+B6 search title", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Mixed_margarine_search_lead", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "J-STAGE domain address; article identifier, original text, and numerical values unverified", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S107-M1", "url": null, "parent_url": null }, { "material_type": "Academic-platform domain page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: metadata_search_index. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Search title only; retrieved URL is a domain landing page, not an article locator. Full article, study identifiers and numerical results not obtained.", "material_id": "S107-M2", "url": "https://www.jstage.jst.go.jp/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://www.jstage.jst.go.jp/" } ] }, { "report_id": "S108", "title": "Discovery lead: Kim et al. mixed nutraceutical / LDL stability study, Nutrients 2013;5:5218", "url": "https://www.mdpi.com/2072-6643/5/12/5218", "report_type": "Kim mixed-product/LDL-stability search lead", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Mixed_oxidative_stability_lead", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Historical article access_failed; B5 monotherapy concentration estimate not accepted", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S108-M1", "url": null, "parent_url": null }, { "material_type": "Publisher article page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: access_failed. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Search lead indicates a multicomponent product and LDL oxidative stability; attempted article access failed. No isolated B5 LDL-C estimate accepted.", "material_id": "S108-M2", "url": "https://www.mdpi.com/2072-6643/5/12/5218", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://www.mdpi.com/2072-6643/5/12/5218" } ] }, { "report_id": "S109", "title": "Discovery lead: 2026 dyslipidemia guideline key messages", "url": "https://professional.heart.org/", "report_type": "2026 guideline key-messages search lead", "existence": "A reference in the archived bibliography/historical records; the current external response was not verified.", "acquired_read": "The corresponding Korean/English summaries and bibliographic records in the archived manuscript were read. The linked external original materials were not read in this review.", "study_family": "Guideline_search_lead", "independent_replication": "15 bibliographic records ≠ 15 unique trials. The same Evans full text/abstract, possible preprint, combination protocol/registry, previous pantethine/reviews, different questions, and search/official materials are distinguished; participant summations performed: 0", "observed_result": "Domain root only; full guideline not read; no B5 recommendation extracted", "result_level": "This is content recorded in the archived manuscript. It is not the result of a fresh comparison against current external original material.", "source_evidence_date": "2026-09-15", "materials": [ { "material_type": "Preserved archived-summary bibliography, linked summary/historical access", "public_status": "Locally preserved", "access_status": "Acquired", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-05", "qualification": "The corresponding bibliography and linked summary in the archived manuscript were read. This does not mean that the full text of the original clinical article, protocol, or official document itself was acquired or read.", "material_id": "S109-M1", "url": null, "parent_url": null }, { "material_type": "Professional-society domain page", "public_status": "Unverified (current original-material lookups 0)", "access_status": "Access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "No attempt was made to access this external original material or read its original text in this review. The address recorded in the bibliography is a route to the source; cases with no address or only a domain landing page were also left unchanged. Historical access level in the bibliography: metadata_search_index. The actual historical access date for each material is unverified. The archived manuscript's review date of 2026-09-15 is not the access date of the original material. Historical location: Targeted search returned a domain-root key-messages result, not readable full guideline. No B5-specific efficacy conclusion or recommendation extracted.", "material_id": "S109-M2", "url": "https://professional.heart.org/", "parent_url": null } ], "links": [ { "label": "Source", "url": "https://professional.heart.org/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions, and reasons for changes, and distinguish variations of the intervention.", "review_level": "Reuse of the preserved methodological principles/version from 1585 and the actual 5 HTML copies; not a new reading of full methodological texts or application of official tools" }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish and link studies and reports, and do not omit a study merely because an outcome is unreported.", "review_level": "Reuse of the preserved methodological principles/version from 1585 and the actual 5 HTML copies; not a new reading of full methodological texts or application of official tools" }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Fix the outcome and effect of interest, and review randomization, deviations, missingness, measurement, and selective reporting.", "review_level": "Reuse of the preserved methodological principles/version from 1585 and the actual 5 HTML copies; not a new reading of full methodological texts or application of official tools" }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance, and applicability. Sample size alone does not determine precision.", "review_level": "Reuse of the preserved methodological principles/version from 1585 and the actual 5 HTML copies; not a new reading of full methodological texts or application of official tools" }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "A harm question may require designs, populations, and follow-up different from those for efficacy. Case reports do not establish incidence rates.", "review_level": "Reuse of the preserved methodological principles/version from 1585 and the actual 5 HTML copies; not a new reading of full methodological texts or application of official tools" } ], "status_dictionary": { "Partly verified": "Some adjacent/bibliographic and historical information verified; gaps remain in direct monotherapy evidence, outcomes, denominators, plans, and access", "Unverified": "The selected direct outcome or necessary material could not be verified within the preserved scope; this does not mean 0 studies or no effect", "Review incomplete": "Original-material comparison/search was not performed within the permitted scope", "Not reported": "A scope-limited status meaning that the item was not stated in the specific material/section read", "Inaccessible": "Used only for material for which access was actually attempted and failed. Not assigned to clinical material in this review", "Insufficient evidence meeting the conditions": "Used only when evidence is insufficient to answer a condition after relevant studies within the defined scope have been reviewed. Not applied comprehensively in this review", "Not applicable": "Extensions to events, optimal dose, persistence, or all populations are not imposed as additional requirements for the selected concentration question; this does not substitute for unverified data", "Conflicting information": "When materials that are difficult to reconcile for the same question, time point, and analysis have been compared. Not assigned merely because a review reports different numerical values", "Met": "Verification of the stated preservation, boundaries/measures/attribution, and material linkages; not direct B5 LDL-C efficacy, full-text reading, or safety certification" }, "study_overlap": { "state": "This list links materials that may overlap. The six groups do not mean six independent clinical trials. S101, S102: F101: excluded from direct scoring; directly eligible=False / S103, S104: F102: excluded from direct scoring; directly eligible=False / S105, S106: F103: excluded from direct scoring; directly eligible=False / L366-1, L366-2, L366-3, S101, S102: pantethine original trials/review and Evans full text/abstract; inclusion in the previous bibliography/cohort relationships remain unresolved, independent-participant summations performed: 0 / L028, L3099: same/adjacent ingredients in different skin/acne questions; not direct LDL-C families / S06, S107, S108, S109: official nutrition/safety, mixed products/different endpoints, and domain search leads; not counted as repeated LDL-C monotherapy trials. S101 PMC and S102 PubMed concern the same Evans pantethine trial. Cohort relationships in other bibliographic records are unverified. Report counts are not summed as independent trial counts or total participant counts.", "unique_trial_count": null, "unique_participant_count": null, "reason": "This list links materials that may overlap. The six groups do not mean six independent clinical trials. S101, S102: F101: excluded from direct scoring; directly eligible=False / S103, S104: F102: excluded from direct scoring; directly eligible=False / S105, S106: F103: excluded from direct scoring; directly eligible=False / L366-1, L366-2, L366-3, S101, S102: pantethine original trials/review and Evans full text/abstract; inclusion in the previous bibliography/cohort relationships remain unresolved, independent-participant summations performed: 0 / L028, L3099: same/adjacent ingredients in different skin/acne questions; not direct LDL-C families / S06, S107, S108, S109: official nutrition/safety, mixed products/different endpoints, and domain search leads; not counted as repeated LDL-C monotherapy trials. S101 PMC and S102 PubMed concern the same Evans pantethine trial. Cohort relationships in other bibliographic records are unverified. Report counts are not summed as independent trial counts or total participant counts." }, "history": [ { "date": "2026-11-02", "kind": "Separation of the public view and data", "view_version": "1.0", "change": "A public view and data were prepared from the existing 36 items. No new clinical search, change in verification status, or scoring was performed." } ], "language": "en", "translation_date": "2026-11-02" }