{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3066-s1", "verdict_number": "3066", "title": "Aged garlic extract 2.4-7.2 g/day × Reduction of ex vivo platelet aggregation", "view_version": "1.0", "view_created_date": "2026-10-26", "criteria_version": "1.1", "criteria_date": "2026-10-05", "review_date": "2026-10-05", "legacy_evidence_date": "2026-09-08", "review_scope": { "materials_read": "Retained Korean/English summaries and case-specific condition/application records", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Prepared from retained summaries and condition-application records. External abstracts, full texts, registration, protocols and analysis plans remain unread. Historical review records do not establish current independent clinical validation.", "date_meaning": "The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, "claim_context": { "population": "The scope mainly concerns healthy adults. S01 records a total sample of 34 people, but actual eligibility, baseline characteristics, sex, age and arm-specific analysis denominators remain unverified. S02’s healthy-male information is not transferred to S01.", "intervention": "Oral AGE capsules from aged Allium sativum L. clove extract. Product, manufacture/batch, aging process, SAC specification and actual administered material remain unverified. Other garlic preparations are not interchangeable.", "dose": "The nominal dose list is 2.4, 4.8 and 7.2 g/day. A partial reduction in collagen-induced aggregation is described, but the corresponding dose, concentration and time point remain unverified. It is not attributed to the highest dose.", "comparator": "The selected collagen response compares oral AGE with placebo. Actual placebo composition, common management, between-arm contrast, analysis population and parallel/crossover structure remain unverified.", "endpoint": "The endpoint is collagen-induced ex vivo platelet aggregation. Only the direction of partial reduction is recorded; whether the measure is maximum aggregation or threshold and the analysis cell remain unverified. Units, concentration, specimen processing, formal estimates and P/CI are also unverified.", "duration": "Only a short-term scope with durations differing across trials is recorded. S01’s exact duration and interval from last dose to blood draw/testing remain unverified.", "excluded_extensions": [ "Original C, 46 points, Warning and assessment axes are historical values of the broad parent verdict. No separate grade, score or effect is created for the selected collagen question.", "S01’s 34 people are not divided into dose-arm, specimen or response-specific analysis counts or added as independent people across three tables of the same trial.", "S02’s 1995 garlic preparation has unverified AGE formulation identity and matching measure and concentration. No significant oral effect does not establish an effect of 0, equivalence or direct refutation of identical AGE.", "The S03 review’s 12 RCTs, 595 people and 6 positive trials describe its overall summary. Selected AGE/collagen trials and inclusion/overlap of S01/S02 remain unverified; the review is not added as new independent trials or people.", "The specimen collagen response does not establish thrombosis prevention, thrombolysis, aspirin replacement or bleeding safety. Long-term persistence, optimal dose, harms and vulnerable groups are extension questions requiring separate direct material." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Is the collagen-induced ex vivo platelet aggregation linked as a separate question and distinguished from the original broad verdict?", "needed": "A record linking the original verdict claim, empty subclaims, derived question and parent verdict", "role": "Required", "role_reason": "This prevents biologically different agonist responses from being combined into one estimate or a new grade.", "application_exception": "Only this item evaluates the recorded boundary. Other items requiring actual dose, denominator and estimate material are assessed separately.", "criterion": "Retain the original wording, identify the collagen-induced ex vivo platelet aggregation as a separate target, and state that the derived ID is not an original array index.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "If the boundary changes, redefine the agonist, measure and comparison as a new question and preserve the previous version.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original wording is reduced ex vivo platelet aggregation, and subclaims is an empty array. This table covers only the collagen-induced ex vivo platelet aggregation. C, 46 points and all axes are historical values of the broad parent.", "condition_status": "Met", "status_reason": "For this narrow record-boundary criterion, the original claim, empty array, agonist distinction and formal derived assignment are linked. This does not establish clinical efficacy.", "missingness": "No new individual grade or score is created; the separate grade remains unrecorded.", "uncertainty": "No new individual grade or score is created; the separate grade remains unrecorded. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "A record linking the original verdict claim, empty subclaims, derived question and parent verdict" }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are S01's actual AGE formulation and SAC specification verified for the collagen comparison?", "needed": "Original product name, aging process, capsule content, batch SAC specification and actual administration data", "role": "Required", "role_reason": "Even the same extract name does not make raw garlic, powder, oil or isolated SAC interchangeable with AGE.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link the actual AGE capsule product and ingredient specifications to the exposure used for collagen analysis.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "In controlled studies with matching products and batches, link the administered substance and ingredient specifications to the analysis cell.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original claim conditions describe AGE capsules and unverified trial-specific SAC specifications. Raw garlic, garlic powder, oil, allicin, black garlic, fermented garlic and isolated SAC are not interchangeable.", "condition_status": "Partly verified", "status_reason": "The nominal AGE capsule formulation is recorded, but actual product, batch and SAC specifications remain to be verified.", "missingness": "Product and SAC specifications remain unverified in the retained material.", "uncertainty": "Product and SAC specifications remain unverified in the retained material. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Original product name, aging process, capsule content, batch SAC specification and actual administration data" }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Is the 1995 garlic preparation the same formulation as the AGE exposure in this collagen question?", "needed": "Actual ingredients, processing, product and specifications of the 1995 preparation and a mapping to S01 AGE", "role": "Required", "role_reason": "This prevents another garlic preparation from being promoted to direct AGE replication or refutation.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Actual material must verify formulation and ingredient identity between the 1995 garlic preparation and S01 AGE.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "After checking formulation identity, compare whether the collagen measure matches; retain a separate preparation question if identity differs.", "current_reports": [ "S02" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S02's title refers to a garlic preparation and a small sample of healthy men. The retained summary does not specify whether the preparation was aged, its product or specifications. The 1995 report also lists collagen and summarizes no significant oral effect. However, AGE formulation identity and matching measure and concentration remain unverified.", "condition_status": "Unverified", "status_reason": "S02 supplies related context, but original material confirming the same exposure as AGE is absent.", "missingness": "Unverified formulation identity is not a judgment about significance or worldwide absence of research.", "uncertainty": "Unverified formulation identity is not a judgment about significance or worldwide absence of research. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual ingredients, processing, product and specifications of the 1995 preparation and a mapping to S01 AGE" }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are the baseline status, eligibility and demographics of the actual collagen analysis population verified?", "needed": "S01 arm-specific age, sex, baseline platelet function, eligibility/exclusions and medication-use tables", "role": "Required", "role_reason": "A title-level description of mainly healthy adults cannot establish representation of a particular patient or co-medication group.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link actual collagen specimen population characteristics and eligibility to S01's analysis population.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "In studies reporting baseline characteristics, compare selection and arm balance alongside the collagen results.", "current_reports": [ "S01", "S02" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The claim conditions mainly concern healthy adults and treat antiplatelet co-use separately. S01 is summarized only as 34 people, without arm-specific demographics or baseline characteristics. S02's healthy-male information is not inherited by S01.", "condition_status": "Partly verified", "status_reason": "The original scope mainly concerns healthy adults, but S01's actual selection and arm-specific baseline data remain unverified.", "missingness": "Age, sex, baseline platelet values and selection remain unverified.", "uncertainty": "Age, sex, baseline platelet values and selection remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "S01 arm-specific age, sex, baseline platelet function, eligibility/exclusions and medication-use tables" }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Are the nominal dose list and the actual dose and intake for the collagen result linked?", "needed": "Arm-specific planned doses, actual intake, adherence data and dose mapping for the collagen result cell", "role": "Required", "role_reason": "This prevents automatic attribution of a shared dose list or another agonist's dose signal to this result.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link each actual dose to its collagen result, comparator and time point; a nominal list alone does not establish a particular cell.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "After obtaining dose-specific comparison tables, analyze planned collagen dose comparisons separately from actual intake.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original dose list is 2.4, 4.8 and 7.2 g/day. The 2.4, 4.8 and 7.2 g/day values are the trial's dose list. The partial collagen reduction is not linked to a particular dose, concentration or time point, so it is not attributed to the highest dose.", "condition_status": "Partly verified", "status_reason": "The dose list and a narrative clue for the selected response exist, but actual intake and result-cell mapping remain unverified.", "missingness": "Actual intake, arm-specific adherence and the exact dose cell for the positive/weak signal remain unverified.", "uncertainty": "Actual intake, arm-specific adherence and the exact dose cell for the positive/weak signal remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm-specific planned doses, actual intake, adherence data and dose mapping for the collagen result cell" }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are exposure duration and the interval from the last dose to collagen blood collection and testing verified?", "needed": "S01 start/end dates, actual weeks of exposure, last-dose/blood-draw interval and testing time", "role": "Required", "role_reason": "This prevents short-term wording from becoming a specific number of weeks or a pharmacokinetic testing time.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify actual exposure duration and blood-draw/testing intervals by arm for the selected collagen analysis.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "In comparisons with a defined timeline, record pre/post exposure and last-dose intervals under the same conditions.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The claim conditions describe only short-term exposure with durations differing across trials. S01's actual duration, blood-draw timing and interval from the last dose are absent.", "condition_status": "Unverified", "status_reason": "The short-term description alone cannot establish the required actual timeline.", "missingness": "Exact trial-specific duration and blood-draw/testing time remain unverified.", "uncertainty": "Exact trial-specific duration and blood-draw/testing time remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "S01 start/end dates, actual weeks of exposure, last-dose/blood-draw interval and testing time" }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Are the placebo's actual composition and common management verified for the collagen comparison?", "needed": "Placebo composition, dosing schedule, diet/management and arm differences", "role": "Required", "role_reason": "A placebo label alone cannot establish that AGE was the only difference.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link placebo composition, schedule, common management and the actual comparison of interest to arm-specific data.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "In placebo comparisons with matching management, examine arm-specific management changes in relation to collagen results.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The claim conditions name placebo as comparator, and S01 is described as a placebo dose-ranging trial. Actual placebo composition, diet and arm-specific common management data are absent.", "condition_status": "Partly verified", "status_reason": "Nominal placebo control is identified, but actual composition, schedule and common management remain to be verified.", "missingness": "Placebo composition and common management remain unverified.", "uncertainty": "Placebo composition and common management remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Placebo composition, dosing schedule, diet/management and arm differences" }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Are the actual randomization, blinding and design procedures verified?", "needed": "Methods for sequence generation/concealment, parallel/crossover structure, blinding maintenance and baseline balance", "role": "Required", "role_reason": "This prevents a randomized double-blind summary from being read as proof of no allocation error.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link S01's actual design, allocation/concealment and blinding methods to the collagen results.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "After comparing methods, assess allocation and specimen evaluation blinding according to the actual design.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 is described as a randomized, double-blind, placebo-controlled dose-ranging trial. Actual sequence generation/concealment, parallel/crossover structure and blinding assessment data are absent.", "condition_status": "Partly verified", "status_reason": "The summary classifies the design, but actual conduct has not been verified.", "missingness": "Design structure, allocation/concealment, baseline balance and maintained blinding remain unverified.", "uncertainty": "Design structure, allocation/concealment, baseline balance and maintained blinding remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Methods for sequence generation/concealment, parallel/crossover structure, blinding maintenance and baseline balance" }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Can information on concomitant drugs, diet, adherence and exposure deviations affecting the collagen difference be verified?", "needed": "Arm-specific anticoagulants/antiplatelets, diet, rescue treatment, adherence/discontinuation and analysis handling", "role": "Required", "role_reason": "This keeps simultaneous exposures affecting platelet function separate from the selected intervention's contribution.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link actual co-exposure, adherence, deviations and their handling to the collagen result population.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "In comparisons recording actual co-medication and deviations, review them according to the effect of interest and analysis handling.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original population scope treats antiplatelet co-use separately and gives safety warnings. S01's actual co-medication, adherence, rescue/discontinuation data remain unverified.", "condition_status": "Unverified", "status_reason": "Background-risk warnings exist but do not replace actual arm-specific exposure records.", "missingness": "Arm-specific co-exposure, adherence and deviations in relation to the effect of interest remain unverified.", "uncertainty": "Arm-specific co-exposure, adherence and deviations in relation to the effect of interest remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm-specific anticoagulants/antiplatelets, diet, rescue treatment, adherence/discontinuation and analysis handling" }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are the exact measure, unit and direction of the collagen result verified?", "needed": "Original collagen result tables, threshold/maximum-aggregation definitions, units and positive cells", "role": "Required", "role_reason": "Agonists and measures represent different analyses; the aggregation label alone does not imply the same effect.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link the selected collagen measure, unit and direction to the original table without substituting another measure.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Fix the collagen measure and unit from the original result table before comparing between-arm results on the same measure.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01's selected clue is a partial reduction in collagen-induced aggregation. Only the direction of partial reduction is recorded; whether the measure is maximum aggregation or threshold and the corresponding analysis cell remain unverified. The representative endpoint in the claim conditions broadly includes maximum aggregation or threshold.", "condition_status": "Partly verified", "status_reason": "A directional or threshold clue exists, but the unit, definition and original analysis cell remain to be verified.", "missingness": "The exact measure, unit, threshold definition and analysis cell remain unverified.", "uncertainty": "The exact measure, unit, threshold definition and analysis cell remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Original collagen result tables, threshold/maximum-aggregation definitions, units and positive cells" }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are collagen concentration, specimen processing, equipment and repeated-specimen structure verified?", "needed": "Agonist concentration, PRP/specimen processing, equipment, measurement time and repeat/specimen identifiers", "role": "Required", "role_reason": "This prevents assuming that participant counts equal specimen counts or concentration-specific repeats.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify the concentration, specimen/equipment and repeat structure of the selected collagen response.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Specify matching concentration, specimen processing and assay methods, and design comparisons accounting for within-person repeats.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original material summarizes agonist-specific ex vivo aggregation but does not give collagen concentration, specimen processing, equipment or specimen repeat counts.", "condition_status": "Unverified", "status_reason": "Without actual analysis conditions, effects of concentration or assay method cannot be compared.", "missingness": "Concentration, specimen preparation, equipment, measurement window and repeated-specimen counts remain unverified.", "uncertainty": "Concentration, specimen preparation, equipment, measurement window and repeated-specimen counts remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Agonist concentration, PRP/specimen processing, equipment, measurement time and repeat/specimen identifiers" }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Which between-arm contrast and analysis population does the selected collagen value estimate?", "needed": "Baseline change/end values, between/within-arm comparisons, ITT/PP, models and dose/concentration-specific repeat handling", "role": "Required", "role_reason": "This prevents converting a directional summary into a formal placebo contrast or adjusted effect.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify the actual analysis, denominator, model and measure definition for the between-arm contrast of interest.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare the original analysis or an appropriate comparison model specifying the between-arm contrast; retain within-arm change separately.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01's result is a directional summary of a partial reduction in collagen-induced aggregation. Whether it is a within-arm change or a placebo comparison, end value/change, ITT/PP or adjusted/unadjusted model is unverified in the current material.", "condition_status": "Unverified", "status_reason": "The directional summary lacks the required formal contrast and analysis definition. Valid unadjusted comparisons are allowed; adjustment is not universally required.", "missingness": "Between-arm estimate, analysis population, model and repeat-handling definitions remain unverified.", "uncertainty": "Between-arm estimate, analysis population, model and repeat-handling definitions remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Baseline change/end values, between/within-arm comparisons, ITT/PP, models and dose/concentration-specific repeat handling" }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Can the original 34 people be distinguished from dose-specific collagen allocation, measurement and analysis denominators?", "needed": "Flow of total recruitment/allocation, dose/control-specific measured/analyzed people and specimen counts", "role": "Required", "role_reason": "This prevents dividing a shared trial total into dose/endpoint analysis n or adding it across three tables.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Use actual material to distinguish the original 34-person sample description from dose/control and collagen analysis denominators.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare person/specimen identifier flow and state the analysis unit and arm-specific denominators.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 reports n as 34 people. Whether this is recruitment, allocation, completion or analysis and each arm's collagen analysis count remain unverified. Three tables share the same 34-person trial.", "condition_status": "Partly verified", "status_reason": "The reported 34 people are identified, but actual dose/endpoint denominators are absent. They were not filled by division or addition.", "missingness": "Allocation, completion and analysis stages and arm/concentration-specific person/specimen counts remain unverified.", "uncertainty": "Allocation, completion and analysis stages and arm/concentration-specific person/specimen counts remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Flow of total recruitment/allocation, dose/control-specific measured/analyzed people and specimen counts" }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Are missingness, losses, failed measurements and their handling verified for the collagen analysis?", "needed": "Dose-arm loss reasons, specimen/result missingness, analysis exclusions, imputation/sensitivity analyses", "role": "Required", "role_reason": "The 34-person count and directional summary cannot establish that everyone was measured and analyzed.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link selected collagen measurement/analysis losses and their handling to the actual flow.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Review how missingness affects the contrast of interest using original data recording the types of omission.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "Beyond 34 people, the current evidence table has no actual loss, specimen-failure or analysis-exclusion counts or handling. Generic English sample-size wording is not actual denominator data.", "condition_status": "Unverified", "status_reason": "Loss/missingness data are absent, so handling cannot be verified; losses were not filled as 0.", "missingness": "Loss counts, reasons, handling and sensitivity analyses remain unverified.", "uncertainty": "Loss counts, reasons, handling and sensitivity analyses remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Dose-arm loss reasons, specimen/result missingness, analysis exclusions, imputation/sensitivity analyses" }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Are the formal collagen effect estimate, variance, P value and confidence interval verified?", "needed": "Dose/concentration/time-specific arm values, SD/SE, between-arm estimate, P/CI and denominators", "role": "Required", "role_reason": "This prevents partial reduction or a weak signal from establishing magnitude, precision or significance.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Link the formal collagen estimate and variance/interval to the corresponding analysis cell.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Obtain original estimates and intervals on the same collagen measure to compare magnitude and uncertainty.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The selected direction is a partial reduction in collagen-induced aggregation, but actual arm values, SD/SE, P and CI are absent from current evidence/citation summaries. No new difference, variance or interval is calculated.", "condition_status": "Unverified", "status_reason": "Numerical data needed for the estimate and precision are absent, so verification is not possible.", "missingness": "Arm values, SD/SE, formal estimate, P, CI and denominators remain unverified.", "uncertainty": "Arm values, SD/SE, formal estimate, P, CI and denominators remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Dose/concentration/time-specific arm values, SD/SE, between-arm estimate, P/CI and denominators" }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Do the registered/protocol/SAP prespecified collagen endpoint and report agree?", "needed": "S01 actual registration identifier, protocol, SAP, dates/versions and analysis hierarchy", "role": "Required", "role_reason": "Planning material is needed to examine possible selection of favorable findings among multiple agonists.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Compare prespecified collagen endpoints, doses, concentrations, time points and analyses with results.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare dated plans and result tables to distinguish prespecified from post hoc analyses of the selected response.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01's registration field says not verified. Original plans, registration number, SAP and time-specific prespecified collagen definitions are absent. Non-acquisition does not establish non-registration or selective reporting.", "condition_status": "Unverified", "status_reason": "Without prior planning material, adherence to the actual plan cannot be checked.", "missingness": "Registration/SAP identity and planned endpoints/analyses remain unverified.", "uncertainty": "Registration/SAP identity and planned endpoints/analyses remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "S01 actual registration identifier, protocol, SAP, dates/versions and analysis hierarchy" }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are the testing scope and adjustment for multiple doses, agonists, concentrations/time points verified?", "needed": "Testing family, prespecified primary/secondary endpoints, all analysis tables and multiplicity handling", "role": "Required", "role_reason": "This prevents multiple responses from one shared trial from becoming independent confirmations.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify the selected collagen result's hierarchy within all testing and its actual handling.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Examine multiple contrasts and selective reporting in plan-based analyses disclosing all results.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The manuscript notes multiple doses and agonists in the positive trial; S01's evidence weight notes multiplicity and a small sample. Actual test counts, concentration/time lists and adjustment status are absent.", "condition_status": "Partly verified", "status_reason": "Multiplicity is identified as a limitation, but the actual hierarchy, testing family and handling remain unverified.", "missingness": "Prespecified hierarchy, complete test list and adjustment/reporting methods remain unverified.", "uncertainty": "Prespecified hierarchy, complete test list and adjustment/reporting methods remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Testing family, prespecified primary/secondary endpoints, all analysis tables and multiplicity handling" }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Can the reported collagen direction be verified down to the actual measure and dose cell?", "needed": "All favorable/no-difference/unfavorable cells of the selected response and exact analysis locations", "role": "Required", "role_reason": "This prevents a positive direction from becoming a claim of effects at every dose and concentration.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Retain the original direction while verifying its collagen measure, dose, concentration and time-point cell.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare all prespecified collagen dose/concentration cells, including cells without favorable results.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 and S01's citation summary indicate a partial reduction in collagen-induced aggregation. The 2.4, 4.8 and 7.2 g/day values are the trial's dose list. The partial collagen reduction is not linked to a particular dose, concentration or time point, so it is not attributed to the highest dose. Only the direction of partial reduction is recorded; whether the measure is maximum aggregation or threshold and the corresponding analysis cell remain unverified.", "condition_status": "Partly verified", "status_reason": "The direction is retained, but numerical results and conditions for all cells have not been verified.", "missingness": "The exact positive/weak-signal cell and results in the remaining cells remain unverified.", "uncertainty": "The exact positive/weak-signal cell and results in the remaining cells remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "All favorable/no-difference/unfavorable cells of the selected response and exact analysis locations" }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Is S02's null collagen result verified as the same AGE and measure comparison?", "needed": "S02 formulation, population, concentration, measure, formal estimate, denominator and P/CI", "role": "Required", "role_reason": "This retains opposing results without erasing unverified identity.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify whether S02's collagen comparison uses the selected AGE formulation and matching measure/concentration; compare the scope of its original no-difference estimate.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare positive/opposing original tables by formulation and measure; do not interpret nonsignificance as an effect of 0 or equivalence.", "current_reports": [ "S02" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S02 lists collagen as an endpoint and describes no significant oral effect. The 1995 report also lists collagen and summarizes no significant oral effect. However, AGE formulation identity and matching measure and concentration remain unverified. Formal values, P/CI and denominators are also unverified.", "condition_status": "Partly verified", "status_reason": "An opposing related report exists, but direct refutation using the same AGE and measure remains unverified.", "missingness": "Correspondence of formulation, measure, concentration, population, duration and formal estimate remains unverified.", "uncertainty": "Correspondence of formulation, measure, concentration, population, duration and formal estimate remains unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "S02 formulation, population, concentration, measure, formal estimate, denominator and P/CI" }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are the AGE/collagen original trials and results in the 2022 review verified?", "needed": "Review included-trial table and mapping of formulation, agonist, dose, population and endpoint to original results", "role": "Required", "role_reason": "This prevents reusing 12 RCTs and 595 people as the direct trials/denominator for this specific AGE response.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Distinguish the review's directly relevant AGE/collagen trials using the actual included-trial table.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare included trials with original reports, separate formulation/response-specific results and identify participant overlap.", "current_reports": [ "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S03 summarizes 12 RCTs and 595 people, with 6 positive and the rest null; heterogeneity prevents a firm conclusion. Individual formulations, agonists and inclusion of S01/S02 are absent from the retained material.", "condition_status": "Partly verified", "status_reason": "The review's overall scope and directional heterogeneity are recorded, but the trial list matching this response remains unverified.", "missingness": "Selected AGE/collagen trial counts, participant counts and original-table mappings remain unverified.", "uncertainty": "Selected AGE/collagen trial counts, participant counts and original-table mappings remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Review included-trial table and mapping of formulation, agonist, dose, population and endpoint to original results" }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are independent replication and unique participant counts for the same collagen/AGE question verified?", "needed": "Report/original-trial/cohort, included-trial overlap and response-specific analysis mapping", "role": "Required", "role_reason": "This prevents counting the shared 34-person trial, a related-preparation trial and a review as independent replications or unique-participant totals.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify matching formulation, response and comparison relationships for unique trials/participants using actual linking material.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "After checking actual study families and included-trial overlap, examine replication of the same collagen question.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 is a shared 34-person trial. S02's AGE identity and S03's included-trial relationships remain unverified. The 34 and 595 people are not added, and three tables are not counted as three independent trials.", "condition_status": "Unverified", "status_reason": "Material establishing matching replication and unique participant counts is absent.", "missingness": "Unique direct replication and participant counts remain unrecorded.", "uncertainty": "Unique direct replication and participant counts remain unrecorded. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Report/original-trial/cohort, included-trial overlap and response-specific analysis mapping" }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Are important-difference and interpretation criteria justified for this collagen measure?", "needed": "Measure-specific prespecified important difference, assay reproducibility/variation, rationale and original intervals", "role": "Required", "role_reason": "A weak/partial direction without numbers cannot establish an important or sufficient effect.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify the important-difference rationale for the selected measure together with the reported interval.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Specify reproducibility and a justified important difference for the measure, then compare them with formal estimates and intervals.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The selected manuscript response is a partial reduction in collagen-induced aggregation, without important-difference criteria, assay reproducibility or CI data. No arbitrary MCID, minimum n or required weeks are created.", "condition_status": "Unverified", "status_reason": "Without importance criteria and precision data, adequacy cannot be verified.", "missingness": "The relationship between important-difference rationale, measurement variation and intervals remains unverified.", "uncertainty": "The relationship between important-difference rationale, measurement variation and intervals remains unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Measure-specific prespecified important difference, assay reproducibility/variation, rationale and original intervals" }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Is the boundary between the selected ex vivo collagen response and clinical thrombosis/bleeding events distinguished?", "needed": "A record linking the experimental endpoint to the scope of clinical-event/alternative-treatment claims", "role": "Supplementary; required for clinical-event extensions", "role_reason": "This prevents a specimen response from becoming thrombosis prevention, thrombolysis, aspirin replacement or bleeding safety.", "application_exception": "Clinical-event trials are not universally required to verify the narrow experimental response. Clinical extension claims need separate direct material.", "criterion": "Keep the selected experimental endpoint separate from unmeasured clinical thrombosis/bleeding questions.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "If clinical events are the question, examine them in separate comparisons with suitable populations, follow-up and event collection.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original explanation states that clinical thrombosis and bleeding were not measured, and its advertising guidance excludes thrombosis prevention, thrombolysis, aspirin replacement and bleeding-safety claims. Only the selected collagen experimental response is covered.", "condition_status": "Met", "status_reason": "This item asks about the established endpoint boundary. Experimental response and clinical events are separated; clinical efficacy is not established.", "missingness": "Clinical-event effects and safety are not established by this table's experimental endpoint.", "uncertainty": "Clinical-event effects and safety are not established by this table's experimental endpoint. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "A record linking the experimental endpoint to the scope of clinical-event/alternative-treatment claims" }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Is the current scope of PAF, arachidonic acid and other responses distinguished from the collagen result?", "needed": "Current agonist-specific report lists, unverified PAF formulation identity and the AA result gap", "role": "Required", "role_reason": "This prevents transferring adjacent agonist names or another preparation's results to the selected collagen result.", "application_exception": "This criterion checks only the current reporting scope. Successful distinction here does not satisfy actual PAF/AA material requirements.", "criterion": "Keep S02 PAF as context with unverified identity and AA as a result gap named only in the crux; do not combine them with the selected response.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "When new original material for each response appears, define formulation, measure, concentration and comparator separately and examine it in a separate table version.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original crux distinguishes ADP, collagen, epinephrine and arachidonic acid. S02 includes PAF, but its AGE identity is unverified. Direct AA results are not linked in the 3 evidence/3 citation entries. These gaps remain in related PAF/arachidonic acid questions and the parent context.", "condition_status": "Met", "status_reason": "This item asks about distinguishing the current reporting scope. Adjacent responses and result gaps are retained without adding them to the selected collagen estimate.", "missingness": "This does not prove worldwide absence of research or an effect of 0 for PAF/AA.", "uncertainty": "This does not prove worldwide absence of research or an effect of 0 for PAF/AA. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Current agonist-specific report lists, unverified PAF formulation identity and the AA result gap" }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Is there direct material on optimal dose, long-term persistence and collagen response after discontinuation?", "needed": "Prespecified between-dose comparisons, exposure/withdrawal follow-up, long-term collagen results and interactions", "role": "Supplementary; required for dose/persistence extensions", "role_reason": "This prevents some short-term multi-dose directions from becoming an optimal-dose or persistent-effect claim.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify direct comparison and follow-up material matching the extension question.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "If persistence or dose optimization is the objective, design separate prespecified dose comparisons and withdrawal/long-term follow-up.", "current_reports": [ "S01" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original exposure is short-term and varies by trial; only a partial reduction in collagen-induced aggregation is retained. Direct long-term, post-withdrawal and optimal-dose material is absent.", "condition_status": "Unverified", "status_reason": "The original dose-ranging direction and short-term material cannot answer extension questions.", "missingness": "Long-term/withdrawal follow-up, optimal-dose comparisons and interactions remain unverified.", "uncertainty": "Long-term/withdrawal follow-up, optimal-dose comparisons and interactions remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Prespecified between-dose comparisons, exposure/withdrawal follow-up, long-term collagen results and interactions" }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are actual bleeding, adverse-event and discontinuation collection data verified for the same AGE exposure?", "needed": "Event definitions, active/spontaneous collection, timing, exposure/denominators, severity and discontinuation tables", "role": "Supplementary; required for harm interpretation", "role_reason": "This prevents platelet responses or warning sentences from becoming actual adverse-event collection results or safety certification.", "application_exception": "Separate this experimental aggregation comparison from actual harms. Unverified event material does not mean 0 adverse events, safety or absence of experimental results.", "criterion": "Link actual harm events, collection methods, exposure duration, denominators and discontinuation outcomes to the same population/exposure.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "For harm questions, examine separate material with event definitions, collection systems and appropriate follow-up.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original safety category is Warning, concerning unsupervised use with anticoagulants, antiplatelets, bleeding disorders and around surgery. Actual bleeding-event counts, collection, discontinuations and denominators are absent from the evidence table.", "condition_status": "Unverified", "status_reason": "The warning scope is identified, but actual event-collection and harm-estimate data remain unverified.", "missingness": "Harm diagnosis, collection, timeline, denominators and discontinuation data remain unverified.", "uncertainty": "Harm diagnosis, collection, timeline, denominators and discontinuation data remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Event definitions, active/spontaneous collection, timing, exposure/denominators, severity and discontinuation tables" }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Is direct harm information verified for anticoagulant/antiplatelet co-use, bleeding disorders and surgical populations?", "needed": "Exposure, baseline risk, duration, harm events and comparison material in vulnerable/co-medication groups", "role": "Supplementary; required for vulnerable-group safety extensions", "role_reason": "This prevents extrapolating responses mainly from healthy adults to safety in high-risk populations.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Verify direct exposure/event material and interaction information for each relevant group.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "For co-medication/vulnerable-group questions, use suitable separate comparison/follow-up designs recording baseline risk and actual exposure.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The manuscript warns these groups and treats antiplatelet co-use separately. Actual harm comparisons, denominators and long-term follow-up for each group are absent from the retained evidence table.", "condition_status": "Unverified", "status_reason": "The caution scope exists, but direct vulnerable-group material is absent, so harm magnitude or safety cannot be verified.", "missingness": "Direct material on vulnerable-group, co-medication/long-term harms and interactions remains unverified.", "uncertainty": "Direct material on vulnerable-group, co-medication/long-term harms and interactions remains unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Exposure, baseline risk, duration, harm events and comparison material in vulnerable/co-medication groups" }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Are actual funding, product support and employment/COI disclosures verified for the collagen material?", "needed": "Original S01/S02 funding, product support, author employment/patents/COI and S03 included-trial material", "role": "Supplementary; required for independence claims", "role_reason": "This prevents an original independent-summary label or academic-research wording from establishing independent funding or no product provision.", "application_exception": "This criterion requires actual material verification for the collagen-induced ex vivo platelet aggregation. Values for other agonists, formulations or doses, or successful preservation, do not replace the required actual material.", "criterion": "Check actual disclosures and product-support scope separately for each report/original trial.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare original disclosures and interpret results separately from study families and product support.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 records unverified product-support details, S02 unverified funding, and S03 academic research with mixed original-trial funding. Actual employment, product provision, COI wording and original-trial funding are absent.", "condition_status": "Unverified", "status_reason": "Unverified support details cannot establish independence or absence of conflicts.", "missingness": "Product support, authors/institutions, COI and review original-trial funding remain unverified.", "uncertainty": "Product support, authors/institutions, COI and review original-trial funding remain unverified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Original S01/S02 funding, product support, author employment/patents/COI and S03 included-trial material" }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Are study-family and review-recitation relationships for the three reports and shared collagen results stated?", "needed": "Verified/unverified relationships among 3 reports, PMID/DOI, shared trials and review inclusion", "role": "Required", "role_reason": "Bibliographic record counts must be distinguished from independent study counts.", "application_exception": "This evaluates only the distinction of recorded relationships. Success does not establish direct replication or unique study counts.", "criterion": "Record the shared 34-person S01 trial, related S02 preparation, S03 review and uncertain inclusion relationships separately.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "Compare original trial identifiers with included-trial tables and update links when new overlap relationships are found.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "S01 PMID 11238801 is one multi-dose/response trial. S02 PMID 8582091 reports another garlic preparation; S03 PMID 36222178 is a 12-RCT review. Actual review inclusion remains unverified.", "condition_status": "Met", "status_reason": "This item asks for an honest verified/unverified distinction in family attribution records. Direct independent replication counts remain unverified in the separate unique-replication criterion.", "missingness": "Unverified review/original-trial inclusion and unique-participant totals are retained.", "uncertainty": "Unverified review/original-trial inclusion and unique-participant totals are retained. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Verified/unverified relationships among 3 reports, PMID/DOI, shared trials and review inclusion" }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are the original broad C46, all axes and the English-placeholder correction event preserved?", "needed": "The complete original record, both languages, axes, empty arrays/strings and original correction location/date", "role": "Required", "role_reason": "This prevents using historical scores to determine condition status or promoting generic verification English into actual analysis values.", "application_exception": "This is a preservation criterion and does not satisfy unverified clinical-material requirements in other items.", "criterion": "Preserve original grade/score/axes, both languages and correction wording in their original types; create no separate collagen grade.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "For future corrections, separate the before-text, event, new version and reason, then compare related observations/conditions.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "Original C, 46 points, B/S/R0/I1/EX/B2/CX and empty subclaims/deliberation are preserved. The original verdict-review date is 2026-09-08 and the correction event is 2026-09-14. The correction describes replacing English placeholders, but some current evidence English remains generic verification wording. These strings are also retained and are not used as actual n/P/CI.", "condition_status": "Met", "status_reason": "This item asks about preserving original values and the correction event. Complete original material and types are retained without creating effects, grades or English clinical values.", "missingness": "The correction event and original review date are not report-specific full-text access dates.", "uncertainty": "The correction event and original review date are not report-specific full-text access dates. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "The complete original record, both languages, axes, empty arrays/strings and original correction location/date" }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are the original review date, correction date and current review scope distinguished?", "needed": "Original verdict-review date, correction event, currently read inputs and records of absent cut-off/access fields", "role": "Required", "role_reason": "This prevents backdating actual individual access or a latest search cut-off to the historical review date.", "application_exception": "This criterion labels the sheet’s scope. It does not establish a successful new search or resolution of clinical gaps.", "criterion": "Distinguish local retained-record conversion from historical review/correction; do not infer absent cut-off or access dates.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "If new material is permitted, add search/access/review dates and actual locations as separate events.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The original review date is 2026-09-08 and the correction date is 2026-09-14. Original search-cut-off and report-specific access-date/reading-scope fields are absent. This review date is 2026-10-05; all current inputs were read without new external searches or full-text reading.", "condition_status": "Met", "status_reason": "This item asks about date/scope labeling. Different events are distinguished and absent individual access dates remain unrecorded.", "missingness": "No latest comprehensive literature search or verification of worldwide research absence was performed.", "uncertainty": "No latest comprehensive literature search or verification of worldwide research absence was performed. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Original verdict-review date, correction event, currently read inputs and records of absent cut-off/access fields" }, { "item_id": "N32", "question_type": "Evidence condition", "question": "Are current local-summary reading and unread external gateways/full texts distinguished by material?", "needed": "Exact input locations/identity and actual actions for PubMed, DOI and full-text materials", "role": "Required", "role_reason": "This prevents an external link or historical verification wording from becoming current full-text reading.", "application_exception": "External access not attempted is not access failure. Satisfying this recording criterion is separate from satisfying clinical-material requirements.", "criterion": "Link local retained-record reading to actual locations; keep external material as not attempted/unread with false flags.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "For permitted new reading, separately record material type, version, success/failure, sections read, original location and identity.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "The complete current retained source, Korean/English, 3 evidence entries, 3 citations and 1 correction were read locally. Access, acquisition and reading of PubMed gateways, DOI links and original-paper full texts were not attempted. Report-specific historical reading-scope/date fields are absent.", "condition_status": "Met", "status_reason": "This item asks about actual current-action records. Local summaries and unread external material are separated; fields lacking original server metadata remain unrecorded.", "missingness": "Current provision/access status of external physical originals has not been verified.", "uncertainty": "Current provision/access status of external physical originals has not been verified. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact input locations/identity and actual actions for PubMed, DOI and full-text materials" }, { "item_id": "N33", "question_type": "Evidence condition", "question": "Is the remaining scope of external original-table, method and registration comparison stated?", "needed": "collagen original result tables, methods/appendices, actual registration/SAP identity and currently uncompared locations", "role": "Required", "role_reason": "This prevents retained-record self-review from being read as original-paper/official-method execution or independent clinical certification.", "application_exception": "This recording criterion states current review scope. Unperformed review is not promoted to a verified clinical comparison or safety.", "criterion": "Distinguish retained locations actually read from unread external original tables/methods/registration.", "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.", "condition_origin": "These are Chamgap in-house application conditions for the aged-garlic-extract collagen-induced ex vivo platelet-aggregation question, developed with knowledge of the retained content. They do not establish blinding, trial preregistration, official-tool certification or independent clinical validation.", "proposed_research": "If new external comparison is authorized, distinguish material acquisition from analysis methods and update each item according to actual results.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.", "observation": "Selected collagen values, specimen conditions, denominators and original-plan comparisons remain unverified in the retained material. Local item-specific condition/observation review was completed, but no new comparison with external original tables, methods or registration was performed.", "condition_status": "Met", "status_reason": "This item evaluates only the statement of remaining comparison scope. Retained locations and unperformed external comparisons are distinguished; actual material requirements in preceding items remain unverified.", "missingness": "This is not original-clinical-paper certification, execution of official methods or a latest search.", "uncertainty": "This is not original-clinical-paper certification, execution of official methods or a latest search. No new values, denominators, CI, P or grade calculations/reassessment.", "review_date": "2026-10-05", "reading_status": "Full text not read · Stored summary read", "additional_material": "collagen original result tables, methods/appendices, actual registration/SAP identity and currently uncompared locations" } ], "reports": [ { "report_id": "S01", "title": "Steiner M, Li W. J Nutr. 2001;131:980S-984S. PMID: 11238801. DOI: 10.1093/jn/131.3.980S.", "url": "https://pubmed.ncbi.nlm.nih.gov/11238801/", "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.", "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "study_family": "S01 is a shared 34-person multi-dose/response trial. Report counts are distinguished from unique trials/participants; inclusion in S03 remains unverified.", "observed_result": "The retained S01 summary describes a randomized, double-blind, placebo-controlled dose-ranging trial in 34 people. The nominal dose list is 2.4, 4.8 and 7.2 g/day, with only short-term exposure varying across trials retained; the exact S01 duration is unverified. The selected clue is a partial reduction in collagen-induced aggregation. Only the direction of partial reduction is recorded; whether the measure is maximum aggregation or threshold and the analysis cell remain unverified. The 2.4, 4.8 and 7.2 g/day values are the trial’s dose list. The partial collagen reduction is not linked to a particular dose, concentration or time point, so it is not attributed to the highest dose. Actual arm-specific collagen n, values, P/CI, concentration, variance and plans/analyses remain unverified. Product-support details and NCT are retained as unverified.", "result_level": "Direction and scope from the retained summary. The formal selected collagen estimate, CI, denominator and original result cell remain unverified.", "source_evidence_date": "2026-09-08", "materials": [ { "material_type": "Retained verdict summary", "public_status": "Retained verdict summary read", "access_status": "Retained copy acquired; summary read", "acquired": true, "actually_read": "Stored existing review summary read", "as_of": "2026-10-05", "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External PubMed bibliographic/abstract gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External DOI/publisher gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "Original paper full text; direct location/version unverified", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/11238801/" } ], "independent_replication": "Multiple agonists from the same trial are not independent replication. Matching replication and unique participant counts for the selected AGE/collagen question remain unverified.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted." }, { "report_id": "S02", "title": "1995 clinical trial. PMID: 8582091. DOI: 10.1111/j.1440-1681.1995.tb02032.x.", "url": "https://pubmed.ncbi.nlm.nih.gov/8582091/", "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.", "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "study_family": "S02 reports another garlic preparation. AGE formulation identity, matching measure and concentration, and inclusion in S03 remain unverified.", "observed_result": "The retained S02 summary describes a small sample of healthy men in a double-blind placebo trial. The actual preparation is identified only as a garlic preparation; AGE identity, exact n, duration, dose and variance/CI remain unverified. Endpoints are ADP, PAF and collagen; the result is no significant in vivo oral effect. The 1995 report also lists collagen and summarizes no significant oral effect. However, AGE formulation identity and matching measure and concentration remain unverified. Funding and registration remain unverified.", "result_level": "Direction and scope from the retained summary. The formal selected collagen estimate, CI, denominator and original result cell remain unverified.", "source_evidence_date": "2026-09-08", "materials": [ { "material_type": "Retained verdict summary", "public_status": "Retained verdict summary read", "access_status": "Retained copy acquired; summary read", "acquired": true, "actually_read": "Stored existing review summary read", "as_of": "2026-10-05", "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External PubMed bibliographic/abstract gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External DOI/publisher gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "Original paper full text; direct location/version unverified", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/8582091/" } ], "independent_replication": "The related opposing result is retained, but formulation, measure and concentration identity remain unverified. It does not establish independent replication or refutation of the direct AGE collagen result.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted." }, { "report_id": "S03", "title": "2022 systematic review. PMID: 36222178. DOI: 10.1002/ptr.7556.", "url": "https://pubmed.ncbi.nlm.nih.gov/36222178/", "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.", "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.", "study_family": "S03 is a review of 12 RCTs and 595 people, not a newly recruiting trial. Inclusion/overlap of S01/S02 and original trials matching selected AGE/collagen remain unverified.", "observed_result": "The retained S03 summary describes a systematic review of 12 RCTs and 595 people, with 6 positive and the rest null; heterogeneity prevents a firm conclusion. It is described as academic research with mixed original-trial funding. Original trials/unique denominators for the selected AGE/collagen question and inclusion of S01/S02 remain unverified. The review is not added as a new trial or newly recruited participants.", "result_level": "Direction and scope from the retained summary. The formal selected collagen estimate, CI, denominator and original result cell remain unverified.", "source_evidence_date": "2026-09-08", "materials": [ { "material_type": "Retained verdict summary", "public_status": "Retained verdict summary read", "access_status": "Retained copy acquired; summary read", "acquired": true, "actually_read": "Stored existing review summary read", "as_of": "2026-10-05", "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External PubMed bibliographic/abstract gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "External DOI/publisher gateway", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." }, { "material_type": "Original paper full text; direct location/version unverified", "public_status": "External access not attempted; not acquired; unread", "access_status": "External access not attempted; not acquired", "acquired": false, "actually_read": "Not read", "as_of": "2026-10-05", "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/36222178/" } ], "independent_replication": "The review’s overall counts are not direct replication counts for selected AGE/collagen. Actual included trials and overlap were not compared.", "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted." } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed." } ], "status_dictionary": { "Met": "The stated retained information, reading, attribution or counting boundary was checked within limits. This does not certify efficacy, safety, full-text reading or reassessment.", "Partly verified": "Some retained information was checked, but material or conditions required by the criterion remain unverified.", "Unverified": "The criterion cannot be established in the retained record. This does not mean 0 studies, an effect of 0 or absence of harm.", "Not applicable": "This is limited to a specific application exception. It does not substitute for unread material.", "Review incomplete": "Remaining comparison work and its reason are stated separately. This is distinguished from unverified material." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "S01 contains multiple doses and responses from the same 34-person trial. S02 reports another preparation with unverified AGE identity; S03 is a review. Actual review inclusion, overlap with S01/S02 and unique direct trial/participant counts for the selected collagen response remain unverified." }, "history": [ { "date": "2026-10-26", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "The public view and materials were prepared from the existing 33 items. No new clinical search, verification-state change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-26" }