{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3066-s4",
  "verdict_number": "3066",
  "title": "Aged garlic extract 2.4-7.2 g/day × Reduction of ex vivo platelet aggregation",
  "view_version": "1.0",
  "view_created_date": "2026-10-26",
  "criteria_version": "1.2",
  "criteria_date": "2026-10-05",
  "review_date": "2026-10-05",
  "legacy_evidence_date": "2026-09-08",
  "review_scope": {
    "materials_read": "Retained Korean/English summaries and case-specific condition/application records",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Prepared from retained summaries and condition-application records. External abstracts, full texts, registration, protocols and analysis plans remain unread. Historical review records do not establish current independent clinical validation.",
    "date_meaning": "The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
  },
  "claim_context": {
    "population": "The broad scope mainly concerns healthy adults. Direct material linking the small sample of healthy men in the 1995 report to the actual arachidonic acid population or arm-specific analysis counts remains unverified.",
    "comparator": "The selected question is AGE versus placebo. A direct placebo comparison matching the actual arachidonic acid product, population, measure and time, its analysis population and between-arm contrast remain unverified.",
    "endpoint": "The question concerns a gap in direct AGE results for arachidonic acid-induced platelet aggregation. The endpoint name is retained in the Korean/English crux, but direct reports, numerical results, CI and denominators remain unverified in the current 3 evidence entries and 3 citations.",
    "intervention": "The selected conditions concern oral Allium sativum clove aged-extract AGE capsules. The direct arachidonic acid product, batch, manufacture/aging and SAC/ingredients remain unverified. Other garlic preparations are not substituted.",
    "dose": "The broad AGE doses of 2.4, 4.8 and 7.2 g/day belong to a 34-person dose trial on other agonists. Actual arachidonic acid route, dose and intake/adherence remain unverified. The link between nominal doses and the ADP result cell is also unverified.",
    "duration": "Exact arachidonic acid intake duration, blood-draw/testing times, discontinuation/washout and post-discontinuation results remain unverified. The broad short-term, trial-varying description is not converted into a specific duration.",
    "excluded_extensions": [
      "Original C, 46 points, Warning and B/S/R0/I1/EX/B2/CX are historical records of the broad parent verdict. No separate arachidonic acid grade or direct effect is created.",
      "S01’s 34 people are the overall context of another agonist/dose trial. They are neither transferred as arm-specific arachidonic acid analysis counts or unique-replication participants nor added together.",
      "The 1995 report concerns ADP, PAF and collagen; arachidonic acid is not named in its retained endpoint. AGE identity is also unverified. No significant oral effect does not establish an arachidonic acid effect of 0, equivalence or direct AGE refutation.",
      "The review’s 12 RCTs, 595 people and 6 positive trials are overall summary counts. Directly eligible AGE/arachidonic acid trials, results, denominators, overlap and unique replications remain unverified.",
      "Clinical thrombosis prevention, aspirin replacement, optimal dose and long-term persistence are separate extensions beyond this narrow gap question. Bleeding warnings are retained; unverified harms are not converted into safety or absence of events."
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Is the broad parent text distinguished from the arachidonic acid result-gap question?",
      "needed": "The original broad claim, endpoint name in the crux, derived comparison and change history.",
      "role": "Required",
      "role_reason": "Distinguish a named endpoint's evidence gap from the existing broad parent verdict.",
      "application_exception": "This subquestion is not an original subclaim and creates no separate clinical grade.",
      "criterion": "Keep the original effect statement and empty subclaim list unchanged; separately fix the question of direct AGE evidence for arachidonic acid-induced responses.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "If the question changes, compare the explicitly named original endpoint with the new scope.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The original effect statement is reduction of ex vivo platelet aggregation. This table asks about the gap in direct AGE results for the arachidonic acid response separately named in the crux. This subquestion is not an index in the original subclaim array.",
      "condition_status": "Met",
      "status_reason": "The defined boundary is linked to the original text; naming a response creates neither new efficacy evidence nor a paper.",
      "missingness": "The identity of the question is verified. This does not establish that the AGE effect on this response is known.",
      "uncertainty": "The identity of the question is verified. This does not establish that the AGE effect on this response is known.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The original broad claim, endpoint name in the crux, derived comparison and change history."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Is a direct AGE arachidonic acid report and comparison verified?",
      "needed": "Original reports, methods, results and citations linking AGE, arachidonic acid and an actual comparator.",
      "role": "Required",
      "role_reason": "Do not fill an empty result with an invented report.",
      "application_exception": "Do not turn a gap in the current summary into worldwide absence of studies, existence of a paper or a null effect.",
      "criterion": "Identify an actual report establishing formulation, population, arachidonic acid endpoint, placebo and timing together.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "First compare this endpoint against the complete plans/results of the current 3 reports; record the presence or absence of direct material within a stated scope.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Arachidonic acid is explicitly named as an endpoint in the Korean/English crux. The current 3 evidence entries and 3 citations do not verify a direct result or report for it. All 3 existing reports are retained; no new S04 or paper is created.",
      "condition_status": "Unverified",
      "status_reason": "An endpoint name is not evidence that a direct trial/paper or an AGE-placebo result exists.",
      "missingness": "The identity of a direct AGE report/comparison for this response and its actual result remain unverified.",
      "uncertainty": "The identity of a direct AGE report/comparison for this response and its actual result remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original reports, methods, results and citations linking AGE, arachidonic acid and an actual comparator."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are the selected AGE identity and actual arachidonic acid trial-product specifications verified?",
      "needed": "Product name, manufacture/aging, batch, SAC/ingredients and comparison specifications in methods for the selected response.",
      "role": "Required",
      "role_reason": "Do not transfer selected-response results to another garlic formulation or isolated ingredient.",
      "application_exception": "Do not assume that the 1995 garlic preparation is AGE or an arachidonic acid trial product.",
      "criterion": "Distinguish the broad AGE capsule identity from the product/batch, SAC, manufacture/aging and ingredients used for the selected response.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Verify the product's molecular identity, manufacture and specifications before comparing result eligibility.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The broad claim conditions describe Allium sativum clove aged-extract AGE capsules and unverified trial-specific SAC specifications. The direct arachidonic acid product, batch and SAC/ingredients are currently unverified.",
      "condition_status": "Unverified",
      "status_reason": "A broad product name exists, but direct material for comparing the selected-response trial product's identity is unavailable.",
      "missingness": "Actual product, specification and matching to AGE for the arachidonic acid response are unavailable.",
      "uncertainty": "Actual product, specification and matching to AGE for the arachidonic acid response are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Product name, manufacture/aging, batch, SAC/ingredients and comparison specifications in methods for the selected response."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are actual route, dose and intake linked to the arachidonic acid result verified?",
      "needed": "Product/administration records, intake/adherence, changes/discontinuation and a measurement linkage table for the selected response.",
      "role": "Required",
      "role_reason": "The stated amount for another result does not establish exposure for the selected response.",
      "application_exception": "Do not substitute the nominal 7.2 g/day in the parent dose list or the weak ADP threshold signal at the highest dose for actual arachidonic acid dose/effect. The link between nominal doses and the ADP result cell also remains unverified.",
      "criterion": "Directly verify the route, product/active amount, frequency and adherence of exposure in which this response was measured.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Link exposure records to aggregation-test participants; separate broad nominal doses from actual amounts for the selected response.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The broad original text describes oral AGE at 2.4, 4.8 and 7.2 g/day. These doses belong to the context of a 34-person report on other agonists; actual route, dose and intake for arachidonic acid remain unverified.",
      "condition_status": "Unverified",
      "status_reason": "Actual exposure data linked to the selected-response result are unavailable.",
      "missingness": "Route, dose, adherence and changes/discontinuation for people measured for arachidonic acid remain unverified.",
      "uncertainty": "Route, dose, adherence and changes/discontinuation for people measured for arachidonic acid remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Product/administration records, intake/adherence, changes/discontinuation and a measurement linkage table for the selected response."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are the actual population, eligibility and baseline status for the arachidonic acid response verified?",
      "needed": "Population/eligibility, baseline tables, medication/disease exclusions and analysis population for the selected response.",
      "role": "Required",
      "role_reason": "Do not repurpose a population from another result as the direct selected-response population.",
      "application_exception": "Do not treat healthy adults, 34 people or a small male sample as an established selected-response population.",
      "criterion": "Verify population, inclusion/exclusion, baseline function, disease/co-medication and actual analysis population in the selected-response report.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Link actual participants to aggregation-test data; do not expand applicability using a broad population label.",
      "current_reports": [
        "S01",
        "S02"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The broad population mainly concerns healthy adults; the 1995 candidate is a small sample of healthy men. Direct material linking these to the actual arachidonic acid population or arm-specific analysis n is unavailable.",
      "condition_status": "Unverified",
      "status_reason": "Direct population/eligibility information for a reported selected response is unverified.",
      "missingness": "Population/eligibility, baseline, co-use and representativeness data for arachidonic acid measurements are unavailable.",
      "uncertainty": "Population/eligibility, baseline, co-use and representativeness data for arachidonic acid measurements are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Population/eligibility, baseline tables, medication/disease exclusions and analysis population for the selected response."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are arachidonic acid exposure duration and testing times verified?",
      "needed": "Administration/discontinuation, washout, blood-draw/testing schedules and result times for the selected response.",
      "role": "Required",
      "role_reason": "Do not convert nominal short-term wording into a specific selected-response assessment time.",
      "application_exception": "Do not automatically inherit another trial's duration or persistence of effect.",
      "criterion": "Link administration, discontinuation/washout, blood draw and testing times under the same comparison conditions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Compare planned and actual testing dates; distinguish responses at different times.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The broad duration is short-term and varies by trial; exact administration duration, blood-draw/testing times and post-discontinuation results for arachidonic acid are currently unverified.",
      "condition_status": "Unverified",
      "status_reason": "A direct schedule supporting the selected-response timing conditions is unavailable.",
      "missingness": "Exposure duration and blood-draw/testing/follow-up schedules for arachidonic acid results remain unverified.",
      "uncertainty": "Exposure duration and blood-draw/testing/follow-up schedules for arachidonic acid results remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Administration/discontinuation, washout, blood-draw/testing schedules and result times for the selected response."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are the named arachidonic acid endpoint and exact measure verified?",
      "needed": "Aggregation-test methods, specimen/equipment, agonist concentration, measure/unit and assessment procedures for the selected response.",
      "role": "Required",
      "role_reason": "Existence of a name and actual measurement are different facts.",
      "application_exception": "Do not select broad maximum aggregation or threshold as the exact measure for this response.",
      "criterion": "Retain the endpoint name in the crux; verify maximum aggregation/threshold, agonist concentration, specimen, test method, unit and direction.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Directly link methods to result measures; distinguish ADP/other-agonist material.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The Korean/English crux distinguishes arachidonic acid from other agonists. Maximum aggregation/threshold, concentration, test method, unit and direction for this response remain unverified in retained evidence.",
      "condition_status": "Partly verified",
      "status_reason": "The endpoint name is verified, while actual measurement conditions remain unresolved.",
      "missingness": "Measure, concentration, unit and collection/assessment procedures for arachidonic acid aggregation testing are unavailable.",
      "uncertainty": "Measure, concentration, unit and collection/assessment procedures for arachidonic acid aggregation testing are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Aggregation-test methods, specimen/equipment, agonist concentration, measure/unit and assessment procedures for the selected response."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are allocation, blinding and co-use for a direct arachidonic acid comparison verified?",
      "needed": "Original methods, comparator composition, allocation/concealment, co-use/adherence and assessment blinding for the selected response.",
      "role": "Required",
      "role_reason": "An RCT label alone does not establish that a comparison for another response exists.",
      "application_exception": "Do not turn an unverified selected-response study into an established parallel/crossover design or randomization failure.",
      "criterion": "Verify actual comparator, allocation/concealment, baseline, co-use/adherence and assessment procedures for the selected-response result.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Identify a direct selected-response report before comparing its methods with actual conduct.",
      "current_reports": [
        "S01",
        "S02"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "S01 is a randomized double-blind placebo dose trial; S02 is a double-blind placebo trial. Neither design label is linked to direct arachidonic acid results; selected-response allocation, co-use and blinding remain unverified.",
      "condition_status": "Unverified",
      "status_reason": "A design for another endpoint is not verified as a direct selected-response design.",
      "missingness": "Direct comparator, allocation/concealment, co-use, baseline and assessment-procedure data for the selected response are unavailable.",
      "uncertainty": "Direct comparator, allocation/concealment, co-use, baseline and assessment-procedure data for the selected response are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original methods, comparator composition, allocation/concealment, co-use/adherence and assessment blinding for the selected response."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are the actual direction and effect value for arachidonic acid verified?",
      "needed": "Selected-response result tables, original arm-level observations, effect direction/unit and contrast definition.",
      "role": "Required",
      "role_reason": "Do not invent positive, no-difference or unfavorable results.",
      "application_exception": "Do not turn an unverified result into an effect of 0, a null effect or an opposing result.",
      "criterion": "Link original results, between-arm/within-arm contrasts, unit, timing and analysis for this response to an actual report.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Extract the selected-response result directly from the original report; attribute actual values, comparison and time.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The current 3 evidence entries and 3 citations do not verify actual arachidonic acid effect values, direction or analysis results. Reductions for other agonists or the 1995 nonsignificant wording are not substituted.",
      "condition_status": "Unverified",
      "status_reason": "Without a direct original selected-response result, observations remain unrecorded.",
      "missingness": "An original location for direct arachidonic acid direction, effect, timing and analysis is unavailable.",
      "uncertainty": "An original location for direct arachidonic acid direction, effect, timing and analysis is unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Selected-response result tables, original arm-level observations, effect direction/unit and contrast definition."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are allocation, analysis and missing-data n for arachidonic acid verified?",
      "needed": "Arm-level flow, measured/analyzed n and reasons/handling of missing data for each selected-response aggregation test.",
      "role": "Required",
      "role_reason": "Totals for other endpoints are not selected-response denominators.",
      "application_exception": "Do not add 34 and 595 or calculate a new unique participant count.",
      "criterion": "Verify arm-specific allocated/measured/completed/analyzed n, attrition reasons and missing-data handling for the selected response.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Link analysis populations to reports, participants and aggregation tests; do not substitute overall totals across them.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "S01's 34 people, S02's small sample and S03's 12 RCTs/595 people are their respective report contexts. Arm-specific allocated, measured and analyzed n and missing data for arachidonic acid remain unverified.",
      "condition_status": "Unverified",
      "status_reason": "Evidence linking existing report totals to actual selected-response denominators is unavailable.",
      "missingness": "Analyzed n, completion, missing data and attrition reasons/handling for the selected response are unavailable.",
      "uncertainty": "Analyzed n, completion, missing data and attrition reasons/handling for the selected response are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Arm-level flow, measured/analyzed n and reasons/handling of missing data for each selected-response aggregation test."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are selected-response analysis, variance, CI and important differences verified?",
      "needed": "Selected-response analysis plans, estimates, variance/CI and support for important-difference criteria.",
      "role": "Required",
      "role_reason": "Do not judge precision or sufficiency from broad axes or sample sizes.",
      "application_exception": "Do not invent CI, P, an effect of 0 or a minimum participant threshold.",
      "criterion": "Verify models, assignment/adherence effects, SD/SE, CI and important-difference criteria for arachidonic acid estimates.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "When actual estimates and intervals are obtained, compare them with planned analyses and important-difference criteria.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Arachidonic acid effect estimates, models, SD/SE, CI, significance level and important-difference criteria remain unverified. The broad original EX/CX axes are not an individual selected-response analysis.",
      "condition_status": "Unverified",
      "status_reason": "Without selected-response effects and variance data, an interpretable interval cannot be verified.",
      "missingness": "Original estimates, variance, intervals and importance criteria are unavailable; they are not filled by new calculations.",
      "uncertainty": "Original estimates, variance, intervals and importance criteria are unavailable; they are not filled by new calculations.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Selected-response analysis plans, estimates, variance/CI and support for important-difference criteria."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are planned versus actual arachidonic acid measurement or omission verified?",
      "needed": "Original registration/protocols, complete agonist plans, actual aggregation tests/results and change history.",
      "role": "Required",
      "role_reason": "Do not turn a summary gap into established selective reporting across the entire paper.",
      "application_exception": "Do not treat unobtained registration as nonregistration or a crux name as preregistration.",
      "criterion": "Verify selected-response plans, registration, dose/concentration/timing, analysis, actual publication reporting and reasons for changes.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Compare initial plans with actual specimens/results; distinguish unplanned, unmeasured, summary-omitted and unreported results.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Registration is marked unconfirmed in the original 3 evidence entries. Naming arachidonic acid in the crux does not verify that it was actually planned, measured or omitted. Comparison of plans, registration and results remains unverified.",
      "condition_status": "Unverified",
      "status_reason": "An endpoint name proves neither planning, conduct nor omission; actual comparison material is unavailable.",
      "missingness": "Selected-response prespecification, measurement conduct, reasons for nonreporting/changes and multiplicity rules are unavailable.",
      "uncertainty": "Selected-response prespecification, measurement conduct, reasons for nonreporting/changes and multiplicity rules are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration/protocols, complete agonist plans, actual aggregation tests/results and change history."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are other-agonist signals from the 34-person AGE trial retained unchanged?",
      "needed": "S01's complete agonist plans/results, dose-specific tables and presence/absence of the selected response.",
      "role": "Required",
      "role_reason": "Do not erase existing positive adjacent evidence merely to leave a gap.",
      "application_exception": "Do not substitute ADP threshold for reduced arachidonic acid maximum aggregation.",
      "criterion": "Retain S01's partial collagen/epinephrine reductions and weak highest-dose ADP threshold under their original endpoints; do not transfer them to the selected response.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Retain other-agonist signals; compare actual planning, measurement and results for the selected response against the original report.",
      "current_reports": [
        "S01"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Known results of the 34-person AGE dose trial are partial collagen/epinephrine reductions and a weak ADP threshold signal at the highest dose. They are not promoted to arachidonic acid results.",
      "condition_status": "Met",
      "status_reason": "Actual original reported results are retained with their endpoint boundaries.",
      "missingness": "Signals for other endpoints are verified. Original S01 results/plans for the selected response remain unverified.",
      "uncertainty": "Signals for other endpoints are verified. Original S01 results/plans for the selected response remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "S01's complete agonist plans/results, dose-specific tables and presence/absence of the selected response."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Is the opposing 1995 result retained without transferring it to the selected response?",
      "needed": "Complete 1995 product/agonist methods, results and formulation specifications.",
      "role": "Required",
      "role_reason": "Prevent both discarding an opposing result and transferring it to the wrong selected response.",
      "application_exception": "Do not treat nonsignificance as equivalence, AGE ineffectiveness or arachidonic acid ineffectiveness.",
      "criterion": "Retain the 1995 ADP/PAF/collagen result and unverified preparation identity; distinguish them from direct arachidonic acid refutation.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Compare the product and complete endpoint table; verify whether the selected response is direct and the original scope of the opposing result.",
      "current_reports": [
        "S02"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The 1995 garlic preparation concerns ADP, PAF and collagen aggregation and is retained as no significant in vivo oral effect. Arachidonic acid is not named in its retained endpoint, and matching to the AGE formulation remains unverified.",
      "condition_status": "Met",
      "status_reason": "The opposing context is retained without becoming a direct selected-response null effect or effect of 0.",
      "missingness": "The original scope of the opposing report is verified. Measurement of the selected response in the entire paper and actual formulation identity remain unverified.",
      "uncertainty": "The original scope of the opposing report is verified. Measurement of the selected response in the entire paper and actual formulation identity remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete 1995 product/agonist methods, results and formulation specifications."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are the broad 12-RCT review results and inclusion scope for the selected response verified?",
      "needed": "Review included-trial tables, products/agonists, results/timing, denominators and overlap tables.",
      "role": "Required",
      "role_reason": "Review direction and direct selected-response results are different facts.",
      "application_exception": "Do not turn 6 positive trials into 6 positive selected-response trials or count the review as separate clinical replication.",
      "criterion": "Retain the review's 12 RCTs, 595 people and 6 positive/rest null results; verify actual included AGE/arachidonic acid trials and results.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Separate the review by formulation and agonist; compare positive/no-difference results and directly eligible scope.",
      "current_reports": [
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The review reports 12 RCTs/595 people, 6 positive and the rest null, with heterogeneity preventing a firm conclusion. Included AGE arachidonic acid trials, results and denominators remain unverified in the current summary.",
      "condition_status": "Partly verified",
      "status_reason": "The overall review direction is known, but the eligible selected-response subset is unverified.",
      "missingness": "Overall review counts cannot verify selected-response trial numbers, participants or effects.",
      "uncertainty": "Overall review counts cannot verify selected-response trial numbers, participants or effects.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Review included-trial tables, products/agonists, results/timing, denominators and overlap tables."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are the same 34 people, review included trials and selected-response families distinguished?",
      "needed": "A linkage table for registration/papers, recruitment/period, product, selected-response results and review included trials.",
      "role": "Required",
      "role_reason": "Do not count the same participants as independent populations for different endpoints.",
      "application_exception": "Do not assume that an arachidonic acid selected-response family exists or automatically generate unique counts.",
      "criterion": "Verify the same 34 people across original doses/endpoints and overlap from review recitation/included trials; leave the selected-response unique-family count unresolved.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Create a report-trial-specimen/participant-endpoint linkage table; distinguish multiple reports and included trials.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "S01's multiple doses/agonists belong to the same 34-person report context; S03 is a 12-RCT review. Overlap of S01/S02 with included review trials and the number of direct selected-response families remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "Report types and the shared trial context are known, but complete comparison of included-trial identity/overlap remains unresolved.",
      "missingness": "Unique selected-response trials/participants and overlap between the review and original reports remain unverified.",
      "uncertainty": "Unique selected-response trials/participants and overlap between the review and original reports remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "A linkage table for registration/papers, recruitment/period, product, selected-response results and review included trials."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Is independent direct AGE arachidonic acid replication verified?",
      "needed": "Identity, product, population, comparison, results/timing and family tables for unique direct selected-response trials.",
      "role": "Required",
      "role_reason": "Do not inherit original R0/I1 as an individual selected-response replication verdict.",
      "application_exception": "Unverified does not establish 0 studies worldwide or absence of effect.",
      "criterion": "Verify unique independent results under matching selected-response formulation, population, comparison, measure and timing conditions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "After verifying directly eligible conditions, compare independent-family results and differences in conditions.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "With direct selected-response results unverified, independent AGE arachidonic acid replication is also unverified. Positive/opposing other-agonist results or a review are not selected-response replication results.",
      "condition_status": "Unverified",
      "status_reason": "Independent replication cannot be certified without direct identity and results.",
      "missingness": "Directly eligible families and the distribution of replication results for the selected response remain unverified.",
      "uncertainty": "Directly eligible families and the distribution of replication results for the selected response remain unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Identity, product, population, comparison, results/timing and family tables for unique direct selected-response trials."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are original funding clues and selected-response product/author independence verified?",
      "needed": "Funding/COI, product support and author/institution information for original reports and included trials.",
      "role": "Supplementary; required for independence claims",
      "role_reason": "Unverified funding establishes neither independent funding nor absence of bias.",
      "application_exception": "Do not use the generic English funding field as actual verification of selected-response interests.",
      "criterion": "Retain S01 unverified product-support details, S02 unverified funding and S03 academic/mixed funding; verify selected-response funding/product/author/COI.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Identify an eligible selected-response report before separately comparing funding, product and author relationships.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Original funding values for all reports are retained. S01 product-support details and S02 funding are unverified; S03 has academic/mixed original-trial funding. Without direct selected-response report identity, product/author/COI information is also unverified.",
      "condition_status": "Partly verified",
      "status_reason": "Overall report funding clues exist, while selected-response independence remains unresolved.",
      "missingness": "Direct selected-response funding, product provision, author/institution/patent, declared COI and included-trial relationships are unavailable.",
      "uncertainty": "Direct selected-response funding, product provision, author/institution/patent, declared COI and included-trial relationships are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Funding/COI, product support and author/institution information for original reports and included trials."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are bleeding, event collection, denominators and follow-up for selected-response exposure verified?",
      "needed": "A product-matched safety population, AE definitions/collection, event/person counts, exposure/follow-up and discontinuation/comparison.",
      "role": "Supplementary; required for numerical harm claims",
      "role_reason": "Do not convert unverified harms into no harm.",
      "application_exception": "Do not turn an unrecorded selected-response result into 0 events or substitute 34/595 as harm denominators.",
      "criterion": "Distinguish the aggregation-test gap from actual bleeding/severity/discontinuation definitions, comparisons, event/person counts, exposure/follow-up and collection.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Link selected-response exposure to actual safety populations/events; distinguish aggregation-test results from risk values.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The original broad statement that clinical thrombosis or bleeding was not measured is retained. Selected-response exposure identity, bleeding event/person counts, collection, duration, comparison, discontinuation and denominators remain unverified.",
      "condition_status": "Unverified",
      "status_reason": "An experimental endpoint name and broad warnings do not provide selected-response safety tallies.",
      "missingness": "Harm definitions/collection, denominators, time, comparison and discontinuation information for matching selected-response exposure are unavailable.",
      "uncertainty": "Harm definitions/collection, denominators, time, comparison and discontinuation information for matching selected-response exposure are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "A product-matched safety population, AE definitions/collection, event/person counts, exposure/follow-up and discontinuation/comparison."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are original bleeding warnings and direct co-use/vulnerable-group data verified?",
      "needed": "Products, exposure, events, follow-up, alternative explanations and original warning sources by co-use/group.",
      "role": "Supplementary; required for the stated safety claim",
      "role_reason": "Retain warnings separately from the efficacy gap.",
      "application_exception": "Retaining an original warning creates no new harm-causality verdict, safety grade or dosing prescription.",
      "criterion": "Retain original anticoagulant/antiplatelet, bleeding-disorder and surgical warnings; verify direct selected-response exposure, events/alternatives and long-term/rare-harm information.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Compare original warning support and actual group-specific safety data separately; do not certify personal safety.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Warnings advise against unsupervised use with anticoagulants/antiplatelet medicines, bleeding disorders and around surgery. Direct selected-response exposure, events, follow-up and interaction magnitudes in those groups remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "Warning groups and scope are known, while actual vulnerable-group/co-use information remains unresolved.",
      "missingness": "Exposure, events, alternative causes/adjustment and long-term/rare-harm data for these co-use/vulnerable groups are unavailable.",
      "uncertainty": "Exposure, events, alternative causes/adjustment and long-term/rare-harm data for these co-use/vulnerable groups are unavailable.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Products, exposure, events, follow-up, alternative explanations and original warning sources by co-use/group."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Does the named response also answer thrombosis-prevention or treatment-replacement questions?",
      "needed": "Definitions, comparators, denominators, follow-up and clinical results for a separate event question.",
      "role": "Supplementary; required only for clinical extensions",
      "role_reason": "An experimental response name alone does not establish clinical prevention.",
      "application_exception": "Not applicable does not mean no clinical events, no harm or an effect of 0.",
      "criterion": "Distinguish the selected-response aggregation-test gap from separate questions of clinical thrombosis/bleeding, thrombolysis and aspirin replacement.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Frame clinical-event questions under separate conditions; examine designs/follow-up different from aggregation testing.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The selected question concerns a gap in direct evidence for arachidonic acid-induced responses. It makes no claim about clinical thrombosis prevention, thrombolysis, aspirin replacement or bleeding safety.",
      "condition_status": "Not applicable",
      "status_reason": "Separate clinical-event/treatment-replacement claims are outside the current question; event trials are not imposed as mandatory.",
      "missingness": "This table does not verify a direct clinical-event effect. The selected-response result itself also remains unverified.",
      "uncertainty": "This table does not verify a direct clinical-event effect. The selected-response result itself also remains unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Definitions, comparators, denominators, follow-up and clinical results for a separate event question."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are optimal dose, long-term effects and subgroups needed for this gap question?",
      "needed": "If an extension is requested, direct selected-response dose comparisons, discontinuation/long-term and prespecified subgroup data.",
      "role": "Supplementary; required only for extension claims",
      "role_reason": "Do not repurpose another dose trial as selected-response optimization.",
      "application_exception": "Do not erase other favorable results because a direct selected-response result is unavailable.",
      "criterion": "Distinguish direct selected-response result identity from separate dose, discontinuation/long-term and subgroup-effect questions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "After verifying direct selected-response conditions, separately review prespecified analyses and effect modification for each extension.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "This question asks whether direct AGE arachidonic acid material is verified. It makes no new optimal-dose, post-discontinuation persistence or special-subgroup effect claim.",
      "condition_status": "Not applicable",
      "status_reason": "Distinguish identity/result gaps from separate extensions; do not automatically make extension studies mandatory.",
      "missingness": "Retain the existing selected-response gap without adding every extension study as a new deficiency.",
      "uncertainty": "Retain the existing selected-response gap without adding every extension study as a new deficiency.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "If an extension is requested, direct selected-response dose comparisons, discontinuation/long-term and prespecified subgroup data."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are local summaries of the reports distinguished from unread external material?",
      "needed": "Actual material-specific access/acquisition/reading records, versions/locations and physical material.",
      "role": "Required",
      "role_reason": "A link or summary does not establish acquisition of original selected-response material.",
      "application_exception": "Do not inherit a report's access history onto a DOI gateway or treat unattempted access as failed access.",
      "criterion": "Distinguish 3 evidence entries/3 citations and actual Korean/English local reading from unattempted, unacquired and unread external PubMed/DOI/full texts.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "In authorized later reading, record material, level and version separately; compare summaries against original results.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The complete retained summary and all reports were read. External PubMed/DOI gateways and paper full texts remain unattempted, unacquired and unread; no direct arachidonic acid material was newly acquired.",
      "condition_status": "Met",
      "status_reason": "Actual local summary reading and unread external material are separated and linked to exact source locations/identity.",
      "missingness": "The summary-reading scope is verified. External material types, responses, abstracts/full texts and licenses are unverified.",
      "uncertainty": "The summary-reading scope is verified. External material types, responses, abstracts/full texts and licenses are unverified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual material-specific access/acquisition/reading records, versions/locations and physical material."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are original reference dates and corrections distinguished from individual access dates?",
      "needed": "Historical material-specific access/version records and complete versions before/after corrections.",
      "role": "Required",
      "role_reason": "A global review date is not an access date for each external material.",
      "application_exception": "Do not turn historical research descriptions into current reading of arachidonic acid full texts.",
      "criterion": "Retain the original review date 2026-09-08 and correction 2026-09-14; distinguish the actual current date from unrecorded individual access dates.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Separate reference-date, correction and actual-reading events; compare dates and material levels.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "The original reference date and correction date for generic English wording are retained historically. Material-specific access date, reading scope and location are absent and unrecorded; current local review time is recorded separately.",
      "condition_status": "Met",
      "status_reason": "Event attribution and absent fields are retained without backdating historical access to the present.",
      "missingness": "Historical access dates/full-text levels of individual materials remain unverified. Only the distinction between dates is verified.",
      "uncertainty": "Historical access dates/full-text levels of individual materials remain unverified. Only the distinction between dates is verified.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Historical material-specific access/version records and complete versions before/after corrections."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Is the scope of a current complete literature check for the arachidonic acid gap available?",
      "needed": "Contemporaneous queries/dates, inclusion/exclusion, agonist/formulation candidates and unpublished/correction/retraction logs.",
      "role": "Required",
      "role_reason": "Reading the complete current source differs from an exhaustive current clinical-literature check.",
      "application_exception": "Do not turn 0 new searches into 0 selected-response studies or established nonreporting across the entire paper.",
      "criterion": "Verify actual queries, dates, inclusion/exclusion, unpublished/correction logs and the scope of the complete current evidence check for AGE arachidonic acid. Separately state the current summary gap and that no new search was performed.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "In a separately authorized update, reproduce search scope using the named response and product conditions; compare actual omissions.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Unverified arachidonic acid results describe the current retained evidence/citation scope. No new search or exhaustive unpublished/correction/retraction check was performed. The original research account separately describes the contemporary 34-person trial, review and opposing trial.",
      "condition_status": "Unverified",
      "status_reason": "Actual search/inclusion logs establishing completeness beyond current material are unavailable.",
      "missingness": "The scope of current selected-response material, unpublished work and corrections/retractions is unverified; absence of research is not established.",
      "uncertainty": "The scope of current selected-response material, unpublished work and corrections/retractions is unverified; absence of research is not established.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Contemporaneous queries/dates, inclusion/exclusion, agonist/formulation candidates and unpublished/correction/retraction logs."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are the C46 parent history and individual arachidonic acid status distinguished?",
      "needed": "The complete original summary, identity, boundaries/verdict/corrections and derived-grade policy.",
      "role": "Required",
      "role_reason": "The broad parent grade does not verify a direct selected-response effect.",
      "application_exception": "Do not turn an unrecorded observation into a numeric 0 or null effect.",
      "criterion": "Retain original grade/score/axes/Warning, all evidence values, empty arrays and corrections; explicitly state that a separate selected-response grade is unrecorded.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, funding and harms in the retained reports. Detailed conditions are Chamgap’s own application.",
      "condition_origin": "These are in-house application conditions for the gap in direct AGE results for arachidonic acid-induced aggregation, developed with knowledge of the retained content. They do not establish blinding, clinical preregistration, official-method certification or independent clinical validation.",
      "proposed_research": "Compare complete preserved original/case values and change events to check that no new selected-response verdict has been created.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "observation": "Original C, 46, B/S/R0/I1/EX/B2/CX and Warning remain historical records of the broad parent verdict. The individual arachidonic acid grade and actual selected-response observations are unrecorded. Generic English sample-size/result fields are not selected-response values or successful reading.",
      "condition_status": "Met",
      "status_reason": "All original typed values and derived boundaries are retained; no new effect or grade is created.",
      "missingness": "Original-value preservation is verified. Selected-response efficacy, method certification and independent clinical validation were not newly performed.",
      "uncertainty": "Original-value preservation is verified. Selected-response efficacy, method certification and independent clinical validation were not newly performed.",
      "review_date": "2026-10-05",
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The complete original summary, identity, boundaries/verdict/corrections and derived-grade policy."
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "The effects of aged garlic extract on platelet aggregation and adhesion in humans",
      "url": "https://pubmed.ncbi.nlm.nih.gov/11238801/",
      "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.",
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "study_family": "S01 concerns other agonists/doses in a shared AGE trial. Direct arachidonic acid results and denominators remain unverified.",
      "independent_replication": "Other-agonist results from the same trial are not counted as direct arachidonic acid replication.",
      "observed_result": "34 people; partial collagen/epinephrine reductions; a weak ADP threshold signal only at the highest dose. A direct result for the selected response is unverified in the current summary.",
      "result_level": "Context from the retained summary; direct AGE/arachidonic acid observations, analysis denominators and numerical results remain unverified.",
      "source_evidence_date": "2026-09-08",
      "materials": [
        {
          "material_type": "External PubMed bibliographic/abstract gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "External DOI/publisher gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Original paper full text; direct location/version unverified",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Retained verdict summary",
          "public_status": "Retained verdict summary read",
          "access_status": "Retained copy acquired; summary read",
          "acquired": true,
          "actually_read": "Stored existing review summary read",
          "as_of": "2026-10-05",
          "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/11238801/"
        }
      ]
    },
    {
      "report_id": "S02",
      "title": "Effect of a garlic preparation on in vitro platelet aggregation in healthy subjects",
      "url": "https://pubmed.ncbi.nlm.nih.gov/8582091/",
      "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.",
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "study_family": "S02 reports another garlic preparation concerning ADP, PAF and collagen. Arachidonic acid is not named in the retained endpoint, and AGE product identity remains unverified.",
      "independent_replication": "A report with unverified formulation, selected endpoint and comparison does not establish independent replication or refutation of identical AGE/arachidonic acid.",
      "observed_result": "A small sample of healthy men; ADP, PAF and collagen; no significant in vivo oral effect. AGE product identity and selected-response-specific estimates/CI remain unverified.",
      "result_level": "Context from the retained summary; direct AGE/arachidonic acid observations, analysis denominators and numerical results remain unverified.",
      "source_evidence_date": "2026-09-08",
      "materials": [
        {
          "material_type": "External PubMed bibliographic/abstract gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "External DOI/publisher gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Original paper full text; direct location/version unverified",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Retained verdict summary",
          "public_status": "Retained verdict summary read",
          "access_status": "Retained copy acquired; summary read",
          "acquired": true,
          "actually_read": "Stored existing review summary read",
          "as_of": "2026-10-05",
          "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/8582091/"
        }
      ]
    },
    {
      "report_id": "S03",
      "title": "Garlic supplementation and platelet aggregation: a systematic review of randomized controlled trials",
      "url": "https://pubmed.ncbi.nlm.nih.gov/36222178/",
      "report_type": "A retained bibliographic/evidence summary. The actual external material type/version and full-text provision remain unverified.",
      "existence": "Stored research and bibliographic summaries exist. Existence, public availability, acquisition and reading of external abstracts, full texts, registration, protocols, analysis plans and original product, funding and harm material remain separately unverified.",
      "acquired_read": "The retained Korean/English summaries and case-specific condition/application records were read. External abstracts, full texts, registration, protocols and analysis plans remain unread, with access not attempted.",
      "study_family": "S03 is an overall review; its included trials matching selected AGE/arachidonic acid and overlap with original reports remain unverified.",
      "independent_replication": "Overall review counts are not direct arachidonic acid replication counts. Actual included trials, products and overlap remain unverified.",
      "observed_result": "12 RCTs and 595 people; 6 positive and the rest null; heterogeneity prevents a conclusion. Included trials, results and overlap for the selected response remain unverified.",
      "result_level": "Context from the retained summary; direct AGE/arachidonic acid observations, analysis denominators and numerical results remain unverified.",
      "source_evidence_date": "2026-09-08",
      "materials": [
        {
          "material_type": "External PubMed bibliographic/abstract gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained PubMed link. Its current response, abstract provision/content and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "External DOI/publisher gateway",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "This is the retained DOI link. Its current response, publisher provision, original-text version and public access were not checked. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Original paper full text; direct location/version unverified",
          "public_status": "External access not attempted; not acquired; unread",
          "access_status": "External access not attempted; not acquired",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-10-05",
          "qualification": "The original paper’s direct physical location, version, provision, public availability, acquisition and actual reading remain unverified. No direct URL is invented. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        },
        {
          "material_type": "Retained verdict summary",
          "public_status": "Retained verdict summary read",
          "access_status": "Retained copy acquired; summary read",
          "acquired": true,
          "actually_read": "Stored existing review summary read",
          "as_of": "2026-10-05",
          "qualification": "Relevant retained summary, evidence and citation content was read. This is not the original clinical paper’s bytes or full text. A report linked to retained summaries and citations. External gateways, full texts, registration, protocols and analysis plans remain unread, with access not attempted in this conversion. The displayed material date is the case-record review date. Original verdict review, correction and case review dates are not historical access dates for individual external materials or search cut-offs. Historical external access dates and reading scope are unrecorded; external access was not attempted in this conversion."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/36222178/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "Limited verification of the retained identity, observation or scope required by this row. This is separate from clinical sufficiency or full-text certification.",
    "Partly verified": "Some facts needed by the question are known, while the stated analysis, population, formulation or denominator remains unverified.",
    "Unverified": "Direct information for this question is unverified in the retained scope. This does not mean an effect of 0, no studies, no harm or an unreviewed table.",
    "Not applicable": "A specific extension obligation lies outside the narrow question. This does not substitute for unread or unverified material.",
    "Not applicable (alias)": "A grey-display alias of Not applicable.",
    "Not read": "The external material was not directly read in the current work. This is separate from reading the retained local summary.",
    "Conflicting data": "Actual disagreement between reports under the same conditions. Differences between other questions alone do not establish conflict."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "S01 concerns other agonists in a shared 34-person AGE dose trial. S02 concerns ADP, PAF and collagen with unverified AGE identity; S03 is a review of 12 RCTs and 595 people. Unique direct arachidonic acid trials/participants and review overlap remain unverified."
  },
  "history": [
    {
      "date": "2026-10-26",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "The public view and materials were prepared from the existing 26 items. No new clinical search, verification-state change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-26"
}