{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "A single 1-g preoperative dose of dried ginger powder × Reduction of nausea incidence within 24 postoperative hours",
  "language": "en",
  "translation_date": "2026-10-25",
  "criteria_version": "1.1",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Retained method-application records were reused. External originals were not reread and method content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "The selected condition for material, identity or preservation was verified; this does not establish efficacy success or independent clinical validation.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which independent postoperative-nausea question is covered?",
      "needed": "ASA I–II adult women; major gynecologic laparotomy/general anesthesia; 1 g given 1 h before surgery; placebo comparison of any nausea within 24 h",
      "role": "Required",
      "role_reason": "Link the original question to the proportion reporting any nausea within 24 h. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not combine nausea severity, vomiting, composite PONV or rescue medication into an independent primary effect.",
      "criterion": "Link the original question to the proportion reporting any nausea within 24 h.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for ASA I–II adult women; major gynecologic laparotomy/general anesthesia; 1 g given 1 h before surgery; placebo comparison of any nausea within 24 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Do the direct and synthesis reports count the same trials more than once?",
      "needed": "The 2006 gynecologic-surgery report, the Chen 2022 review's inclusion table and trial identifiers",
      "role": "Required",
      "role_reason": "Distinguish report/trial families for the direct 120 participants and the review's 14 RCTs/1506 participants without adding them together. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not count a review, its original trials or repeated endpoint/time-point citations as independent replication.",
      "criterion": "Distinguish report/trial families for the direct 120 participants and the review's 14 RCTs/1506 participants without adding them together.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for The 2006 gynecologic-surgery report, the Chen 2022 review's inclusion table and trial identifiers. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are actual reading and the existence of external material distinguished?",
      "needed": "Reading/acquisition histories for the retained record, PubMed bibliography/abstract, full text, registration, protocol and SAP",
      "role": "Required",
      "role_reason": "Display current reading of the stored summary separately from unread external material. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A URL or the original verdict date does not establish full-text reading in this work.",
      "criterion": "Display current reading of the stored summary separately from unread external material.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Reading/acquisition histories for the retained record, PubMed bibliography/abstract, full text, registration, protocol and SAP. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What surgery, anesthesia and adult-women population is covered?",
      "needed": "Eligibility/exclusion for ASA I–II adult women undergoing elective major gynecologic laparotomy under general anesthesia",
      "role": "Required",
      "role_reason": "Distinguish the direct population from cesarean delivery, other surgery/anesthesia, other sexes and baseline conditions. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A shared postoperative-nausea label does not justify transfer to every population.",
      "criterion": "Distinguish the direct population from cesarean delivery, other surgery/anesthesia, other sexes and baseline conditions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Eligibility/exclusion for ASA I–II adult women undergoing elective major gynecologic laparotomy under general anesthesia. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What dried ginger-powder formulation and product specifications are recorded?",
      "needed": "Rhizome, 2 capsules of 500 mg, Khao-la-o powder and ingredient quantification",
      "role": "Required",
      "role_reason": "Distinguish the dried-powder formulation and brand wording from verification of standardization/product support. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not turn a product name into evidence of an extract, company funding or free supply.",
      "criterion": "Distinguish the dried-powder formulation and brand wording from verification of standardization/product support.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Rhizome, 2 capsules of 500 mg, Khao-la-o powder and ingredient quantification. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are a single 1 g dose 1 hour before surgery and follow-up distinguished?",
      "needed": "One 1 g dose (2 capsules of 500 mg), given 1 h before surgery; 24 h follow-up; actual administration/adherence",
      "role": "Required",
      "role_reason": "Record dose, timing and frequency separately from postoperative observation duration. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not fill other doses or repeated regimens with the same effect estimate.",
      "criterion": "Record dose, timing and frequency separately from postoperative observation duration.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for One 1 g dose (2 capsules of 500 mg), given 1 h before surgery; 24 h follow-up; actual administration/adherence. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What placebo and common anesthesia/rescue treatment are described?",
      "needed": "Actual contents of appearance- and odor-matched lactose placebo and the same anesthesia/rescue care",
      "role": "Required",
      "role_reason": "Distinguish planned common care from actual drugs, administration, rescue-treatment differences and handling. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Matching appearance/odor does not verify every blinding procedure or every concomitant treatment.",
      "criterion": "Distinguish planned common care from actual drugs, administration, rescue-treatment differences and handling.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Actual contents of appearance- and odor-matched lactose placebo and the same anesthesia/rescue care. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What outcome is nausea incidence within 24 hours?",
      "needed": "Definition and collection of the proportion reporting any nausea within 24 h",
      "role": "Required",
      "role_reason": "Distinguish events/denominators for a patient proportion from nausea episodes, scores and vomiting. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "The page's selected endpoint does not establish that it was a preregistered primary (1st) endpoint.",
      "criterion": "Distinguish events/denominators for a patient proportion from nausea episodes, scores and vomiting.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Definition and collection of the proportion reporting any nausea within 24 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are scores/severity at 2, 6 and 12 hours the same outcome?",
      "needed": "Definitions, denominators and scales for the review's nausea scores/severity at 2/6/12 h",
      "role": "Required boundary",
      "role_reason": "Attribute positive time-specific score directions to a measure distinct from the proportion affected within 24 h. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not turn scores into 24 h event counts or effects from the direct original trial.",
      "criterion": "Attribute positive time-specific score directions to a measure distinct from the proportion affected within 24 h.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Definitions, denominators and scales for the review's nausea scores/severity at 2/6/12 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are vomiting, composite PONV and rescue-medication outcomes separated?",
      "needed": "Definitions, times and denominators for each outcome, and the review's null-result statements",
      "role": "Required boundary",
      "role_reason": "Retain nausea-benefit statements alongside null statements for other endpoints. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not replace null/nonsignificant findings with an effect of 0, equivalence or absence of a nausea result within 24 h.",
      "criterion": "Retain nausea-benefit statements alongside null statements for other endpoints.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Definitions, times and denominators for each outcome, and the review's null-result statements. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What denominators do 120 participants, 60/60 and 29/60 versus 40/60 represent?",
      "needed": "Allocated/completed/analyzed participants and patients experiencing nausea within 24 h",
      "role": "Required",
      "role_reason": "Retain the original 120 participants, 60/60 and 29/60 versus 40/60 at the reported level. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not assume all allocated, completed, measured and analyzed denominators are identical.",
      "criterion": "Retain the original 120 participants, 60/60 and 29/60 versus 40/60 at the reported level.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Allocated/completed/analyzed participants and patients experiencing nausea within 24 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are missing data, withdrawals and analysis handling verified?",
      "needed": "Arm-specific observation loss within 24 h, withdrawal reasons, analysis populations and handling",
      "role": "Required",
      "role_reason": "Identify the need to verify actual follow-up/completion and missing-data handling beyond the original event denominators. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "No withdrawal/missing-data information does not establish 0 losses or complete follow-up.",
      "criterion": "Identify the need to verify actual follow-up/completion and missing-data handling beyond the original event denominators.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Arm-specific observation loss within 24 h, withdrawal reasons, analysis populations and handling. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Is the stored RR of about 0.725 an original-paper estimate?",
      "needed": "29/60 versus 40/60, P=.042 and the calculated-RR label in the original evidence/bibliography",
      "role": "Required",
      "role_reason": "Label the RR of about 0.725 only as a stored historical calculation and retain the unverified original 95% CI. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not calculate a new RR/RD/NNT/CI or promote the stored value to an original-paper estimate.",
      "criterion": "Label the RR of about 0.725 only as a stored historical calculation and retain the unverified original 95% CI.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for 29/60 versus 40/60, P=.042 and the calculated-RR label in the original evidence/bibliography. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "How are other surgery and cesarean-delivery findings retained?",
      "needed": "Other surgery/anesthesia, cesarean-only Cochrane statements and differences from the direct question",
      "role": "Required boundary",
      "role_reason": "Keep cesarean-only statements of very low certainty and unestablished nausea benefit in a separate context. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not add other surgeries as independent replications under the same gynecologic laparotomy/general-anesthesia conditions.",
      "criterion": "Keep cesarean-only statements of very low certainty and unestablished nausea benefit in a separate context.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Other surgery/anesthesia, cesarean-only Cochrane statements and differences from the direct question. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What do the Korean 2021 narrative, Chen 2022 citation and dates mean?",
      "needed": "The Korean/English narrative about two 2021 meta-analyses, the explicit Chen 2022 citation and original verdict/correction dates",
      "role": "Required",
      "role_reason": "Retain narrative years and citation publication years without inferring collection years or additional reports. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "No new search does not mean 0 studies or verification of current publication/retraction status.",
      "criterion": "Retain narrative years and citation publication years without inferring collection years or additional reports.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for The Korean/English narrative about two 2021 meta-analyses, the explicit Chen 2022 citation and original verdict/correction dates. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "How far are research funding sources verified?",
      "needed": "The direct trial's funding/company role and funding of original trials in the review",
      "role": "Supplementary; required for independent-funding claims",
      "role_reason": "Distinguish the direct trial's unverified funding source from mixed funding statements about the review's original trials. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Historical I1 or a product name does not verify independent funding.",
      "criterion": "Distinguish the direct trial's unverified funding source from mixed funding statements about the review's original trials.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for The direct trial's funding/company role and funding of original trials in the review. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are product supply and support verified?",
      "needed": "Declarations about Khao-la-o powder supply, free provision and roles",
      "role": "Supplementary; required for support-independence claims",
      "role_reason": "Record the product brand separately from actual supply/support scope. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A named product does not establish free supply or absence of support.",
      "criterion": "Record the product brand separately from actual supply/support scope.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Declarations about Khao-la-o powder supply, free provision and roles. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are employee authorship and research teams verified?",
      "needed": "Author affiliations, company employment and team/report-family relationships",
      "role": "Supplementary; required for team-independence claims",
      "role_reason": "Do not use generic English wording to fill employee-authorship or independent-team presence/absence. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A review's repeated direction does not establish same-condition replication by a different independent research team.",
      "criterion": "Do not use generic English wording to fill employee-authorship or independent-team presence/absence.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Author affiliations, company employment and team/report-family relationships. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "How far are declared conflicts and patents verified?",
      "needed": "Author/institution declarations of interests, patents and product roles",
      "role": "Supplementary; required for conflict-of-interest claims",
      "role_reason": "Do not label unread/unverified declarations as no conflicts or no bias. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Historical axes, brands and generic English funding wording do not replace declaration documents.",
      "criterion": "Do not label unread/unverified declarations as no conflicts or no bias.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Author/institution declarations of interests, patents and product roles. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What randomization, concealment and blinding were actually used?",
      "needed": "Sequence generation, concealment, assessors and baseline differences in the double-blind placebo trial",
      "role": "Required",
      "role_reason": "Distinguish the design label from actual method verification and retain unverified limitations. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Matched placebo appearance/odor does not verify every blinding procedure.",
      "criterion": "Distinguish the design label from actual method verification and retain unverified limitations.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Sequence generation, concealment, assessors and baseline differences in the double-blind placebo trial. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Could anesthesia, prophylaxis or rescue-care differences obscure the intervention's contribution?",
      "needed": "Arm-specific anesthetics, prophylactic antiemetics, rescue care, adherence/deviations and handling",
      "role": "Required",
      "role_reason": "Distinguish a same-anesthesia/rescue-care statement from unverified actual administration and analysis backgrounds. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not transfer rescue endpoints or concomitant-treatment differences into the effect of ginger alone.",
      "criterion": "Distinguish a same-anesthesia/rescue-care statement from unverified actual administration and analysis backgrounds.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Arm-specific anesthetics, prophylactic antiemetics, rescue care, adherence/deviations and handling. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Who collected nausea, when and with which scale?",
      "needed": "Questions, assessor blinding, visits, recall and severity measurement for any nausea within 24 h",
      "role": "Required",
      "role_reason": "Attribute patient incidence and score/severity measures to their actual collection methods. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not fill unread details with complete collection, objective measurement or validated scales.",
      "criterion": "Attribute patient incidence and score/severity measures to their actual collection methods.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Questions, assessor blinding, visits, recall and severity measurement for any nausea within 24 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Which intervention effect does the 24 h analysis estimate?",
      "needed": "Assignment/adherence effects, ITT/PP, adjustment and analysis populations/models",
      "role": "Required",
      "role_reason": "Distinguish reported event comparisons from verification of actual analysis definitions. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A denominator of 60 does not justify choosing ITT/PP or performing a new analysis.",
      "criterion": "Distinguish reported event comparisons from verification of actual analysis definitions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Assignment/adherence effects, ITT/PP, adjustment and analysis populations/models. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Was nausea alone a prespecified primary (1st) endpoint?",
      "needed": "Endpoints, times and multiplicity in direct-trial registration, protocol and SAP",
      "role": "Required",
      "role_reason": "Retain the selected nausea outcome within 24 h alongside unverified prespecified primary (1st) status. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "A reported significant P does not prove a prespecified primary (1st) success.",
      "criterion": "Retain the selected nausea outcome within 24 h alongside unverified prespecified primary (1st) status.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Endpoints, times and multiplicity in direct-trial registration, protocol and SAP. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are the original between-group 95% CI and precision verified?",
      "needed": "The reported direct effect, 95% CI, variance and denominator for nausea within 24 h",
      "role": "Required",
      "role_reason": "Distinguish P=.042 and the existing RR calculation from the unverified original interval. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "New intervals calculated from event counts or precision claims from a sample of 120 alone: 0.",
      "criterion": "Distinguish P=.042 and the existing RR calculation from the unverified original interval.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for The reported direct effect, 95% CI, variance and denominator for nausea within 24 h. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "What defines clinical importance of the incidence difference?",
      "needed": "Clinical-importance criteria and reported intervals for the relevant surgery/anesthesia and population",
      "role": "Required",
      "role_reason": "Do not invent a minimum difference or sufficiency threshold without justified criteria and an interval. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not create individual preoperative dosing instructions or recommend replacing prophylactic drugs.",
      "criterion": "Do not invent a minimum difference or sufficiency threshold without justified criteria and an interval.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Clinical-importance criteria and reported intervals for the relevant surgery/anesthesia and population. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Is there independent replication for the same surgery, anesthesia, formulation and nausea outcome within 24 h?",
      "needed": "Original-trial families, research teams and trial-specific results matching the conditions",
      "role": "Required",
      "role_reason": "Distinguish a review's repeated direction from unverified independent replication under the same conditions. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not count 14 RCTs as 14 independent same-condition replications.",
      "criterion": "Distinguish a review's repeated direction from unverified independent replication under the same conditions.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Original-trial families, research teams and trial-specific results matching the conditions. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Does the evidence establish other doses, repeated dosing or optimal timing?",
      "needed": "Direct dose/timing and repeated-regimen comparisons using the same powder formulation",
      "role": "Supplementary; required for optimal-condition claims",
      "role_reason": "Separate the current single 1 g dose given 1 h before surgery from optimal-dose/timing claims. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not rank dose effects across different studies as direct superiority comparisons.",
      "criterion": "Separate the current single 1 g dose given 1 h before surgery from optimal-dose/timing claims.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Direct dose/timing and repeated-regimen comparisons using the same powder formulation. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Does the evidence answer outcomes beyond 24 h or in other populations?",
      "needed": "Delayed nausea after cessation, long-term outcomes, special populations and other anesthesia",
      "role": "Supplementary; required for persistence/extensions",
      "role_reason": "Separate acute observation over 24 h from gaps about persistence, harms and other populations. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not require every long-term question as a necessary condition for the narrow question within 24 h.",
      "criterion": "Separate acute observation over 24 h from gaps about persistence, harms and other populations.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Delayed nausea after cessation, long-term outcomes, special populations and other anesthesia. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Does a nausea result establish vomiting/aspiration prevention or replacement of prophylaxis?",
      "needed": "Direct outcomes for nausea incidence, vomiting, aspiration and prophylaxis replacement",
      "role": "Supplementary; required for extension claims",
      "role_reason": "Do not expand a selected symptom result into clinical-event prevention or drug replacement. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not automatically require aspiration-event trials to identify the nausea question within 24 h.",
      "criterion": "Do not expand a selected symptom result into clinical-event prevention or drug replacement.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Direct outcomes for nausea incidence, vomiting, aspiration and prophylaxis replacement. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Which harms were collected in the direct trial?",
      "needed": "Adverse-event definitions, collection and discontinuation around surgery after a single 1 g powder dose",
      "role": "Supplementary; required for safety claims",
      "role_reason": "Separate nausea-prevention efficacy from collection of ginger-attributed harms. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "An efficacy table or caution advice does not replace a complete adverse-event tally.",
      "criterion": "Separate nausea-prevention efficacy from collection of ginger-attributed harms.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Adverse-event definitions, collection and discontinuation around surgery after a single 1 g powder dose. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "What level of information is the fasting/aspiration caution?",
      "needed": "Original fasting/aspiration caution, actual administration, aspiration events and anesthesia-team decisions",
      "role": "Supplementary",
      "role_reason": "Do not turn caution advice into a risk incidence or ginger's aspiration-prevention effect. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not transfer the trial dose into instructions to self-administer before surgery.",
      "criterion": "Do not turn caution advice into a risk incidence or ginger's aspiration-prevention effect.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Original fasting/aspiration caution, actual administration, aspiration events and anesthesia-team decisions. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "Are harms with anticoagulant/antiplatelet use verified?",
      "needed": "Concomitant drugs, baseline risk, bleeding/interactions and exposure data",
      "role": "Supplementary; required for the specified harm claim",
      "role_reason": "Distinguish original caution advice from unverified interaction/harm magnitudes. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not estimate new bleeding rates or interaction effects or establish safety.",
      "criterion": "Distinguish original caution advice from unverified interaction/harm magnitudes.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Concomitant drugs, baseline risk, bleeding/interactions and exposure data. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Are harm denominators and observation losses verified?",
      "needed": "Arm-specific people/events with harms, exposure time, collection, missingness and discontinuation",
      "role": "Supplementary; required for incidence claims",
      "role_reason": "Distinguish nausea event denominators from denominators for overall harms, bleeding or aspiration incidence. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not read 29/60 versus 40/60 as denominators/incidence for ginger-attributed adverse effects.",
      "criterion": "Distinguish nausea event denominators from denominators for overall harms, bleeding or aspiration incidence.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Arm-specific people/events with harms, exposure time, collection, missingness and discontinuation. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "Are efficacy comparisons distinguished from harm signals and causation?",
      "needed": "The placebo comparison of nausea within 24 h and separate harm, timing, alternative-cause and safety scopes",
      "role": "Required boundary",
      "role_reason": "Do not reverse comparative nausea reduction into a signal that ginger causes nausea. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not use historical C46/caution/cross-check wording as a new efficacy/safety grade or independent clinical certification.",
      "criterion": "Do not reverse comparative nausea reduction into a signal that ginger causes nausea.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for The placebo comparison of nausea within 24 h and separate harm, timing, alternative-cause and safety scopes. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "Are review PROSPERO registration and direct-trial registration distinguished?",
      "needed": "Unverified direct-trial registration, Chen review CRD42020220916 and linked plans",
      "role": "Required",
      "role_reason": "Do not substitute a review registration number for preregistration/endpoints of the original gynecologic trial. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Unacquired registration information does not prove nonregistration or selective reporting.",
      "criterion": "Do not substitute a review registration number for preregistration/endpoints of the original gynecologic trial.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Unverified direct-trial registration, Chen review CRD42020220916 and linked plans. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "What information do generic English evidence-table wording, past corrections and the two languages provide?",
      "needed": "Generic original English participant/funding/endpoint/result/weight wording and the correction statement dated 2026-09-14",
      "role": "Required boundary",
      "role_reason": "Retain actual Korean/English values and the correction statement; do not use generic wording as new verification of denominators, company relationships or results. Without this distinction, populations, endpoints and denominators for the selected nausea outcome within 24 h could be mixed with other results.",
      "application_exception": "Do not overwrite retained English evidence or record a new correction/reassessment because of the reader translation.",
      "criterion": "Retain actual Korean/English values and the correction statement; do not use generic wording as new verification of denominators, company relationships or results.",
      "basis": "Existing method principles distinguish population, formulation, dose, timing, endpoint, comparison, denominators, overlap, support and harms in the retained reports. Detailed conditions are Chamgap's own application.",
      "condition_origin": "These existing in-house conditions are linked to preoperative dried ginger powder and postoperative nausea. They do not establish preregistration, official-tool certification or new independent clinical validation.",
      "proposed_research": "Material needed: Original reports, plans and linked documents for Generic original English participant/funding/endpoint/result/weight wording and the correction statement dated 2026-09-14. First establish whether currently unverified material exists and has been acquired. This records needed materials; no new research was executed."
    }
  ]
}