{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3039-main", "verdict_number": "3039", "title": "Oral curcumin or curcuminoid supplementation across mixed formulations × Reduction of LDL cholesterol in adults with dyslipidemia or metabolic disease", "view_version": "1.0", "view_created_date": "2026-10-24", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-08", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, "claim_context": { "population": "The retained population mixes adults with dyslipidemia, type 2 diabetes, metabolic syndrome and related conditions. Disease, baseline LDL, eligibility, age-specific direct effects and contributing denominators remain incompletely verified.", "intervention": "The record mixes conventional, nano, phytosomal and other oral curcumin/curcuminoid formulations. Products, absorption enhancers, piperine combinations and other routes remain distinct; formulation equivalence is not established.", "dose": "The original record describes trial-specific doses. Total product amounts, active amounts, frequency, adherence and direct dose response remain unverified; a single recommended or optimum dose is not generated.", "comparator": "The retained comparator is placebo or control care. Placebo ingredients, lifestyle management, maintenance/changes of lipid or glucose medicines and added interventions remain incompletely verified. Combined effects are not assigned to curcumin alone or medicine replacement.", "endpoint": "The selected endpoint is blood LDL-C change. SMD and MD in mg/dL, final/change values, adjustment and measurement arrangements remain distinct. HDL, TG, total cholesterol and cardiovascular events address different questions.", "duration": "The retained scope spans weeks to months across trials. Actual treatment, measurement, extraction, follow-up and post-discontinuation timepoints remain incompletely verified; these are not merged into a single fixed timepoint or persistent effect.", "excluded_extensions": [ "The original D/30/Caution and B/S/R0/I2/E0/B2/C0 are retained. Historical cross-checking, independence and generic English verification wording are not inherited as current original-source reading or independent clinical validation.", "R01 SMD −0.17, 95% CI −0.43 to 0.09, P=.20 and R02 MD −4.01 mg/dL, 95% CI −10.96 to 2.95, P=.259 are retained separately. Different scales, populations and formulations do not support conversion, addition or a new pooled estimate.", "The original null interpretation is retained, while lack of significance does not establish no effect or equivalence for every formulation/population. Prespecified importance, direct comparisons, individual effects and clinical events remain separately unverified.", "Roughly 6 to 10 mg/dL lower LDL in some earlier analyses is an original counterview narrative. Its original reports, denominators and intervals are unidentified; it is not assigned to the null R02 result or added as a separately verified report.", "The narrative of meta-analysis comparisons from 2013 to 2025 and the 2022 bibliographies of the two structured citations are both retained. A new 2025 paper, completed current search or reconciled chronology is not invented.", "Two review reports remain distinct from unique original trials, participants and independent teams. Original-trial counts, participant totals, overlap and contributing denominators remain unverified; reviews and samples are not summed or newly certified as independent replication.", "Original gastrointestinal, bleeding and hepatobiliary precautions, and the caution against stopping lipid medicines without appropriate guidance, are retained. Actual harm collection, event counts, exposure/denominators, causality, interactions and long-term safety remain unverified.", "The original evidence date 2026-09-08, correction of 2 English fields on 2026-09-14 and stored-summary production date 2026-10-06 remain distinct. Production timestamps are not completed external-reading/content-review dates; actual review dates remain unrecorded." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which LDL question is addressed?", "needed": "Oral curcumin and blood LDL-C change in adults with dyslipidemia or metabolic disease", "role": "Required", "role_reason": "Material on Oral curcumin and blood LDL-C change in adults with dyslipidemia or metabolic disease is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Oral curcumin and blood LDL-C change in adults with dyslipidemia or metabolic disease must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original eligibility criteria matching population, formulation, comparator and LDL are needed. Other lipids, myocardial infarction and medicine replacement are excluded. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original claim concerns LDL-C reduction in adults with dyslipidemia or metabolic disease. HDL, TG and total cholesterol are separate outcomes.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original eligibility criteria matching population, formulation, comparator and LDL are needed. Other lipids, myocardial infarction and medicine replacement are excluded.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original eligibility criteria matching population, formulation, comparator and LDL are needed. Other lipids, myocardial infarction and medicine replacement are excluded." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are mixed formulations distinguished from individual products?", "needed": "Original-trial composition by conventional, nano and phytosomal formulations", "role": "Required", "role_reason": "Material on Original-trial composition by conventional, nano and phytosomal formulations is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Original-trial composition by conventional, nano and phytosomal formulations must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Active amounts, absorption enhancers and product information are needed. A mixed estimate does not establish efficacy or equivalence for an individual formulation. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The retained formulation mixes conventional, nano and phytosomal oral products. Other formulations, piperine combinations and topical products are not treated as equivalent.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Active amounts, absorption enhancers and product information are needed. A mixed estimate does not establish efficacy or equivalence for an individual formulation.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Active amounts, absorption enhancers and product information are needed. A mixed estimate does not establish efficacy or equivalence for an individual formulation." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What doses and actual exposure are recorded?", "needed": "Total product and active-curcuminoid amounts, frequency and adherence", "role": "Required", "role_reason": "Material on Total product and active-curcuminoid amounts, frequency and adherence is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Total product and active-curcuminoid amounts, frequency and adherence must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original trial records on formulation, dose, co-ingredients and adherence are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "Doses vary by trial. Representative doses, active-amount conversions and recommended amounts are not generated.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original trial records on formulation, dose, co-ingredients and adherence are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial records on formulation, dose, co-ingredients and adherence are needed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are treatment duration and LDL measurement timepoints aligned?", "needed": "Trial-specific durations and LDL timepoints over weeks to months", "role": "Required", "role_reason": "Material on Trial-specific durations and LDL timepoints over weeks to months is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Trial-specific durations and LDL timepoints over weeks to months must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Treatment, measurement, end-of-follow-up and post-discontinuation timepoints, with selection rules, are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The retained duration varies from weeks to months. It is not merged into a single fixed timepoint or persistent effect.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Treatment, measurement, end-of-follow-up and post-discontinuation timepoints, with selection rules, are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Treatment, measurement, end-of-follow-up and post-discontinuation timepoints, with selection rules, are needed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Which diagnoses make up the mixed adult population?", "needed": "Dyslipidemia, T2D, metabolic syndrome and other diagnoses, with baseline LDL", "role": "Required", "role_reason": "Material on Dyslipidemia, T2D, metabolic syndrome and other diagnoses, with baseline LDL is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Dyslipidemia, T2D, metabolic syndrome and other diagnoses, with baseline LDL must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Inclusion tables by diagnosis, baseline LDL, age, comorbidities and eligibility are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The retained population mixes adults with these diagnoses. It is not presented as a single dyslipidemia population.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Inclusion tables by diagnosis, baseline LDL, age, comorbidities and eligibility are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Inclusion tables by diagnosis, baseline LDL, age, comorbidities and eligibility are needed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "How does the T2D analysis relate to the broader analysis?", "needed": "Alignment of T2D eligibility with mixed-disease and formulation scopes", "role": "Required", "role_reason": "Material on Alignment of T2D eligibility with mixed-disease and formulation scopes is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Alignment of T2D eligibility with mixed-disease and formulation scopes must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Alignment of diseases, formulations and timepoints, with original-trial lists shared by the reviews, is needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R02 is a T2D RCT meta-analysis, while R01 mixes diseases and formulations. Two review reports are not counted as two independent original trials.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Alignment of diseases, formulations and timepoints, with original-trial lists shared by the reviews, is needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Alignment of diseases, formulations and timepoints, with original-trial lists shared by the reviews, is needed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "How do comparator arrangements differ?", "needed": "Placebo or control care and common management in each group", "role": "Required", "role_reason": "Material on Placebo or control care and common management in each group is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Placebo or control care and common management in each group must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original-trial records on comparator ingredients, blinding, diet/exercise management and added interventions are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The retained comparator is placebo or control care. Identical placebo and lifestyle-management arrangements across all trials are not established.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original-trial records on comparator ingredients, blinding, diet/exercise management and added interventions are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original-trial records on comparator ingredients, blinding, diet/exercise management and added interventions are needed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Can lipid and glucose medicines be separated from other interventions?", "needed": "Group-specific lipid/glucose medicines, diet and weight changes", "role": "Required", "role_reason": "Material on Group-specific lipid/glucose medicines, diet and weight changes is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Group-specific lipid/glucose medicines, diet and weight changes must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Baseline medicines, treatment changes, adherence and shared care are needed. Curcumin alone or a statin-replacement comparison is not established. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original precaution says not to stop lipid medicines without appropriate guidance. Medicine types, maintenance and changes in included trials are not detailed in the summary.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Baseline medicines, treatment changes, adherence and shared care are needed. Curcumin alone or a statin-replacement comparison is not established.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Baseline medicines, treatment changes, adherence and shared care are needed. Curcumin alone or a statin-replacement comparison is not established." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Are each review's design and eligibility scope retained separately?", "needed": "Search and eligibility criteria for the updated RCT review and T2D RCT review", "role": "Required", "role_reason": "Material on Search and eligibility criteria for the updated RCT review and T2D RCT review is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Search and eligibility criteria for the updated RCT review and T2D RCT review must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Search dates, strategies, eligibility, registration/plans and extraction tables are needed for each review. Currentness and directness are not newly certified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R01 is a systematic review/meta-analysis of RCTs; R02 is a T2D RCT meta-analysis. Disease and formulation scopes differ.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Search dates, strategies, eligibility, registration/plans and extraction tables are needed for each review. Currentness and directness are not newly certified.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Search dates, strategies, eligibility, registration/plans and extraction tables are needed for each review. Currentness and directness are not newly certified." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are the numbers of included trials known?", "needed": "Included RCT counts and study/report links for each review", "role": "Required", "role_reason": "Material on Included RCT counts and study/report links for each review is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Included RCT counts and study/report links for each review must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Inclusion lists, multiple-arm arrangements and duplicate-report links are needed. Unique-trial counts are not generated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R01 describes multiple RCTs with mixed diseases/formulations; R02 describes pooled T2D RCTs. Specific RCT counts are not provided.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Inclusion lists, multiple-arm arrangements and duplicate-report links are needed. Unique-trial counts are not generated.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Inclusion lists, multiple-arm arrangements and duplicate-report links are needed. Unique-trial counts are not generated." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are participants and analysis denominators known?", "needed": "Trial/group denominators for allocation, analysis, completion and LDL measurement", "role": "Required", "role_reason": "Material on Trial/group denominators for allocation, analysis, completion and LDL measurement is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Trial/group denominators for allocation, analysis, completion and LDL measurement must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Allocation, analysis, completion and measurement denominators, with participant-overlap information, are needed. The final unique-participant total remains null. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The stored sample descriptions contain no participant totals or group counts. Generic English wording does not supply actual denominators.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Allocation, analysis, completion and measurement denominators, with participant-overlap information, are needed. The final unique-participant total remains null.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Allocation, analysis, completion and measurement denominators, with participant-overlap information, are needed. The final unique-participant total remains null." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Can trials shared by the reviews be linked?", "needed": "Review-to-original-trial, additional-report and shared-participant links", "role": "Required", "role_reason": "Material on Review-to-original-trial, additional-report and shared-participant links is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Review-to-original-trial, additional-report and shared-participant links must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Article, registration, site/time and sample links are needed. Review estimates are not added or certified as two independent replications. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The two structured reports are the Saeedi and Yuan reviews. Overlap in original trials and participants remains unverified.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Article, registration, site/time and sample links are needed. Review estimates are not added or certified as two independent replications.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Article, registration, site/time and sample links are needed. Review estimates are not added or certified as two independent replications." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "What is the LDL result in the broader updated analysis?", "needed": "R01 SMD, CI and P, with original model and scale", "role": "Required", "role_reason": "Material on R01 SMD, CI and P, with original model and scale is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on R01 SMD, CI and P, with original model and scale must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original pooling tables, standardization, variances, weights, included-trial and timepoint extraction are needed. New values are not calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R01 reports SMD −0.17, 95% CI −0.43 to 0.09, P=.20. Its retained interpretation describes the latest direct LDL synthesis as null.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original pooling tables, standardization, variances, weights, included-trial and timepoint extraction are needed. New values are not calculated.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original pooling tables, standardization, variances, weights, included-trial and timepoint extraction are needed. New values are not calculated." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What is the LDL result in the T2D analysis?", "needed": "R02 MD in mg/dL, CI and P, with the original analysis population", "role": "Required", "role_reason": "Material on R02 MD in mg/dL, CI and P, with the original analysis population is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on R02 MD in mg/dL, CI and P, with the original analysis population must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: T2D included trials, formulations, timepoints, variances/denominators and analysis models are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R02 reports MD −4.01 mg/dL, 95% CI −10.96 to 2.95, P=.259, described as null. R01's SMD is not copied to this report.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: T2D included trials, formulations, timepoints, variances/denominators and analysis models are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "T2D included trials, formulations, timepoints, variances/denominators and analysis models are needed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Are SMD and MD in mg/dL kept without conversion?", "needed": "Units and estimands for standardized and absolute differences", "role": "Required", "role_reason": "Material on Units and estimands for standardized and absolute differences is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Units and estimands for standardized and absolute differences must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original standard deviations, analysis arrangements and direct comparisons addressing the same question are needed. No SMD-to-mg/dL conversion or new pooled estimate is produced. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R01 uses SMD; R02 uses MD in mg/dL. They are not compared, added or converted, and remain within their respective disease/formulation scopes.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original standard deviations, analysis arrangements and direct comparisons addressing the same question are needed. No SMD-to-mg/dL conversion or new pooled estimate is produced.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original standard deviations, analysis arrangements and direct comparisons addressing the same question are needed. No SMD-to-mg/dL conversion or new pooled estimate is produced." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are intervals crossing no effect distinguished from equivalence?", "needed": "Both original CIs and P values, with prespecified importance/equivalence criteria", "role": "Required", "role_reason": "Material on Both original CIs and P values, with prespecified importance/equivalence criteria is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Both original CIs and P values, with prespecified importance/equivalence criteria must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original analysis tables and prespecified importance/equivalence criteria are needed. Lack of significance does not certify effect 0 or equivalence for every formulation. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original CIs are −0.43 to 0.09 and −10.96 to 2.95. The original interpretation as null is retained.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original analysis tables and prespecified importance/equivalence criteria are needed. Lack of significance does not certify effect 0 or equivalence for every formulation.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original analysis tables and prespecified importance/equivalence criteria are needed. Lack of significance does not certify effect 0 or equivalence for every formulation." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Which report underlies the roughly 6–10 mg/dL positive signal?", "needed": "Bibliography, formulations, denominators and CIs for earlier positive analyses", "role": "Supplementary", "role_reason": "Material on Bibliography, formulations, denominators and CIs for earlier positive analyses is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Bibliography, formulations, denominators and CIs for earlier positive analyses must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Articles/years, original trials and direct LDL tables for the positive analyses are needed. Unidentified reports, effects and CIs are not invented. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The counterview mentions roughly 6–10 mg/dL lower LDL in some metabolic-disease analyses. Structured R02 instead reports −4.01 mg/dL, described as null. The positive narrative is not assigned to R02.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Articles/years, original trials and direct LDL tables for the positive analyses are needed. Unidentified reports, effects and CIs are not invented.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Articles/years, original trials and direct LDL tables for the positive analyses are needed. Unidentified reports, effects and CIs are not invented." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are the 2013–2025 narrative and citation years distinguished?", "needed": "Review chronology, search end dates, versions and bibliography alignment", "role": "Required", "role_reason": "Material on Review chronology, search end dates, versions and bibliography alignment is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Review chronology, search end dates, versions and bibliography alignment must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report lists, versions, search dates and original citations for the stated years are needed. No new 2025 paper or completed external current search is created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The research narrative mentions comparisons of meta-analyses from 2013–2025. Both structured citations have 2022 bibliographies. These different original records are retained.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Report lists, versions, search dates and original citations for the stated years are needed. No new 2025 paper or completed external current search is created.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report lists, versions, search dates and original citations for the stated years are needed. No new 2025 paper or completed external current search is created." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "What explains differences and heterogeneity across analyses?", "needed": "Heterogeneity and sensitivity analyses by disease, formulation, duration and model", "role": "Required", "role_reason": "Material on Heterogeneity and sensitivity analyses by disease, formulation, duration and model is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Heterogeneity and sensitivity analyses by disease, formulation, duration and model must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original heterogeneity, sensitivity/classification and extraction tables are needed. Different review scopes are not established as conflicting results from identical original trials; I² and prediction intervals are not invented. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original narrative describes earlier positive/null findings and conclusions varying by disease/formulation. The result fields contain no I² value.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original heterogeneity, sensitivity/classification and extraction tables are needed. Different review scopes are not established as conflicting results from identical original trials; I² and prediction intervals are not invented.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original heterogeneity, sensitivity/classification and extraction tables are needed. Different review scopes are not established as conflicting results from identical original trials; I² and prediction intervals are not invented." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What is known about original-trial allocation, blinding and risk assessment?", "needed": "Original allocation, concealment, blinding/measurement methods and assessment bases", "role": "Required", "role_reason": "Material on Original allocation, concealment, blinding/measurement methods and assessment bases is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Original allocation, concealment, blinding/measurement methods and assessment bases must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original methods, registration/plans and review-level individual assessment bases are needed. Official RoB2/GRADE findings are not generated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The RCT-review design is retained. Original-trial methods and individual risk-assessment material were not externally read in this work.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original methods, registration/plans and review-level individual assessment bases are needed. Official RoB2/GRADE findings are not generated.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original methods, registration/plans and review-level individual assessment bases are needed. Official RoB2/GRADE findings are not generated." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are LDL measurement, change and adjustment arrangements comparable?", "needed": "Assays, fasting, final/change values, baseline adjustment and estimands", "role": "Required", "role_reason": "Material on Assays, fasting, final/change values, baseline adjustment and estimands is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Assays, fasting, final/change values, baseline adjustment and estimands must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Assays, timepoints, extraction tables, variance handling and analysis plans are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The selected endpoint is blood LDL-C change. Original assays, final/change-value definitions and adjustment arrangements are not detailed in the summary.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Assays, timepoints, extraction tables, variance handling and analysis plans are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Assays, timepoints, extraction tables, variance handling and analysis plans are needed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "What attrition, missingness and analysis exclusions are known?", "needed": "Trial-specific missing measurements, withdrawals and analysis sets", "role": "Required", "role_reason": "Material on Trial-specific missing measurements, withdrawals and analysis sets is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Trial-specific missing measurements, withdrawals and analysis sets must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Group-specific flow diagrams, missingness, exclusion reasons, missing-data handling and sensitivity material are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "Stored sample descriptions provide no specific denominators. Unread original trials are not relabeled as having no missingness or withdrawals.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Group-specific flow diagrams, missingness, exclusion reasons, missing-data handling and sensitivity material are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Group-specific flow diagrams, missingness, exclusion reasons, missing-data handling and sensitivity material are needed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are LDL prespecification and reporting choices verified?", "needed": "Primary/secondary endpoints, timepoints and multiplicity plans", "role": "Required", "role_reason": "Material on Primary/secondary endpoints, timepoints and multiplicity plans is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Primary/secondary endpoints, timepoints and multiplicity plans must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Registration, protocols/SAPs and all-timepoint result tables are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "An LDL-only verdict does not mean that every original trial prespecified LDL as its primary (1st) endpoint. Prespecified hierarchy remains unverified.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Registration, protocols/SAPs and all-timepoint result tables are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration, protocols/SAPs and all-timepoint result tables are needed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are disease/formulation subgroups kept separate from overall effects?", "needed": "Subgroup effects/CIs, denominators, prespecification and interactions", "role": "Supplementary", "role_reason": "Material on Subgroup effects/CIs, denominators, prespecification and interactions is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Subgroup effects/CIs, denominators, prespecification and interactions must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Subgroup tables, interactions and distinctions by formulation/duration are needed. The overall SMD is not copied as a disease-specific or product-specific estimate. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original rationale retains the latest direct null LDL result, while the counterview retains positive signals in restricted metabolic-disease analyses.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Subgroup tables, interactions and distinctions by formulation/duration are needed. The overall SMD is not copied as a disease-specific or product-specific estimate.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Subgroup tables, interactions and distinctions by formulation/duration are needed. The overall SMD is not copied as a disease-specific or product-specific estimate." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are other lipid endpoints distinguished from LDL benefit?", "needed": "Outcome-specific definitions and results for HDL, TG and total cholesterol", "role": "Supplementary", "role_reason": "Material on Outcome-specific definitions and results for HDL, TG and total cholesterol is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Outcome-specific definitions and results for HDL, TG and total cholesterol must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original results for other lipids address separate questions. Effects and grades are not merged into the LDL table. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The summary states that these lipids are separate outcomes, and the rationale/advertising limits do not transfer positive TG or total-cholesterol findings to LDL.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original results for other lipids address separate questions. Effects and grades are not merged into the LDL table.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original results for other lipids address separate questions. Effects and grades are not merged into the LDL table." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are statin replacement and myocardial-infarction prevention separate questions?", "needed": "Direct material distinguishing an LDL surrogate from medicine replacement and clinical events", "role": "Supplementary", "role_reason": "Material on Direct material distinguishing an LDL surrogate from medicine replacement and clinical events is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Direct material distinguishing an LDL surrogate from medicine replacement and clinical events must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Direct comparisons on medicine replacement or cardiovascular events are not verified in this material. Efficacy scope is not expanded. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The retained advertising limits do not support statin replacement or myocardial-infarction prevention. The current endpoint is LDL-C.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Direct comparisons on medicine replacement or cardiovascular events are not verified in this material. Efficacy scope is not expanded.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct comparisons on medicine replacement or cardiovascular events are not verified in this material. Efficacy scope is not expanded." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Are replication within a formulation and optimum doses verified?", "needed": "Unique trials, independent teams and direct dose comparisons", "role": "Supplementary", "role_reason": "Material on Unique trials, independent teams and direct dose comparisons is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Unique trials, independent teams and direct dose comparisons must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Direct material on original-trial families, products, teams, doses and timepoints is needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original grading rationale describes conflicting syntheses and a null latest direct main effect. Mixed reviews do not establish formulation-specific replication or optimum doses.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Direct material on original-trial families, products, teams, doses and timepoints is needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct material on original-trial families, products, teams, doses and timepoints is needed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Are four routes of company involvement distinguished?", "needed": "Report/trial-specific funding, product support, employee authorship and COI", "role": "Required", "role_reason": "Material on Report/trial-specific funding, product support, employee authorship and COI is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Report/trial-specific funding, product support, employee authorship and COI must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original support, product-provision, affiliation and COI disclosures for reviews/trials are needed. University researchers do not establish absence of company involvement. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "R01 describes university researchers and mixed funding of included trials; R02 describes limited verification. Generic English funding wording does not complete these four records.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Original support, product-provision, affiliation and COI disclosures for reviews/trials are needed. University researchers do not establish absence of company involvement.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original support, product-provision, affiliation and COI disclosures for reviews/trials are needed. University researchers do not establish absence of company involvement." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Are harm collection methods and event tables known?", "needed": "Definitions, collection and discontinuation for gastrointestinal, bleeding and hepatobiliary events", "role": "Supplementary", "role_reason": "Material on Definitions, collection and discontinuation for gastrointestinal, bleeding and hepatobiliary events is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Definitions, collection and discontinuation for gastrointestinal, bleeding and hepatobiliary events must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Harm methods, severity, occurrence and discontinuation records are needed. Precautions do not establish incidence, causation or safety certification. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original safety detail retains these precautions separately from efficacy. Collection methods and event tables are not preserved in detail.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Harm methods, severity, occurrence and discontinuation records are needed. Precautions do not establish incidence, causation or safety certification.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Harm methods, severity, occurrence and discontinuation records are needed. Precautions do not establish incidence, causation or safety certification." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are harm denominators and exposure kept distinct?", "needed": "Safety populations, dosing, duration, event counts and comparators", "role": "Supplementary", "role_reason": "Material on Safety populations, dosing, duration, event counts and comparators is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Safety populations, dosing, duration, event counts and comparators must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Group-specific safety sets, exposure amounts/time, withdrawals and comparator events are needed. Harm incidence is not calculated or replaced with LDL denominators. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "Sample descriptions express review scopes without participant counts. Durations are mixed too.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Group-specific safety sets, exposure amounts/time, withdrawals and comparator events are needed. Harm incidence is not calculated or replaced with LDL denominators.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Group-specific safety sets, exposure amounts/time, withdrawals and comparator events are needed. Harm incidence is not calculated or replaced with LDL denominators." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are alternative causes and concomitant treatments separated for harms?", "needed": "Comorbidities, medicines, event timing and alternative causes", "role": "Supplementary", "role_reason": "Material on Comorbidities, medicines, event timing and alternative causes is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Comorbidities, medicines, event timing and alternative causes must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Medicine maintenance/changes, baseline disease, event timing, comparators and post-discontinuation course are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original record cautions against stopping lipid medicines without appropriate guidance and retains curcumin precautions separately. Event and co-treatment causation remains unverified.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Medicine maintenance/changes, baseline disease, event timing, comparators and post-discontinuation course are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Medicine maintenance/changes, baseline disease, event timing, comparators and post-discontinuation course are needed." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "Does a bleeding precaution establish a direct interaction result?", "needed": "Distinguishing a bleeding precaution from medicine-specific direct comparisons", "role": "Supplementary", "role_reason": "Material on Distinguishing a bleeding precaution from medicine-specific direct comparisons is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Distinguishing a bleeding precaution from medicine-specific direct comparisons must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Concomitant medicine types, exposure, group-specific events, alternative causes and direct comparisons are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "A bleeding precaution is retained, but medicine-specific incidence and interaction comparisons are not specified. Medicine-specific causal claims are not added here.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Concomitant medicine types, exposure, group-specific events, alternative causes and direct comparisons are needed.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Concomitant medicine types, exposure, group-specific events, alternative causes and direct comparisons are needed." }, { "item_id": "N33", "question_type": "Evidence condition", "question": "Are long-term, hepatobiliary and vulnerable-population harms verified?", "needed": "Long-term/rare harms, hepatobiliary outcomes, vulnerable groups, independent reports and exposure", "role": "Supplementary", "role_reason": "Material on Long-term/rare harms, hepatobiliary outcomes, vulnerable groups, independent reports and exposure is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Long-term/rare harms, hepatobiliary outcomes, vulnerable groups, independent reports and exposure must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Long-term follow-up, independent harm reports, vulnerable-population, exposure/denominator and causal material are needed. No new harm investigation is undertaken. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "Hepatobiliary precautions remain separate from efficacy. Mixed durations of weeks to months do not certify long-term safety.", "condition_status": "Unverified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Long-term follow-up, independent harm reports, vulnerable-population, exposure/denominator and causal material are needed. No new harm investigation is undertaken.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Long-term follow-up, independent harm reports, vulnerable-population, exposure/denominator and causal material are needed. No new harm investigation is undertaken." }, { "item_id": "N34", "question_type": "Evidence condition", "question": "Are stored-summary reading and external original links distinguished?", "needed": "Access tables for stored reports, abstracts, full texts, registration and protocols/SAPs", "role": "Required", "role_reason": "Material on Access tables for stored reports, abstracts, full texts, registration and protocols/SAPs is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Access tables for stored reports, abstracts, full texts, registration and protocols/SAPs must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Unread status remains until actual materials are acquired and reviewed. A URL does not establish reading, accessibility or fulfillment of conditions. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The stored summary and bibliography were read. The two PubMed URLs are original links. External abstracts, full texts, registration and protocols/SAPs remain unread.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: Unread status remains until actual materials are acquired and reviewed. A URL does not establish reading, accessibility or fulfillment of conditions.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Unread status remains until actual materials are acquired and reviewed. A URL does not establish reading, accessibility or fulfillment of conditions." }, { "item_id": "N35", "question_type": "Evidence condition", "question": "How are generic English wording and the historical correction retained?", "needed": "Original Korean/English records and limits of the 2026-09-14 correction", "role": "Supplementary", "role_reason": "Material on Original Korean/English records and limits of the 2026-09-14 correction is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Original Korean/English records and limits of the 2026-09-14 correction must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External English material and historical correction targets are not newly reviewed here. The historical correction is not labeled as completed current QA. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The correction records replacement of English placeholders while retaining grade, score, citations and evidence date. Remaining generic English denominator, result and funding wording is preserved in the original record.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: External English material and historical correction targets are not newly reviewed here. The historical correction is not labeled as completed current QA.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External English material and historical correction targets are not newly reviewed here. The historical correction is not labeled as completed current QA." }, { "item_id": "N36", "question_type": "Evidence condition", "question": "Are original grade, axes, dates and preparation distinguished?", "needed": "Preservation of D30, Caution, axes, evidence date and correction", "role": "Required", "role_reason": "Material on Preservation of D30, Caution, axes, evidence date and correction is needed to connect the relevant formulation, population, comparator, LDL scale/timepoint, report/trial, denominator, overlap or harm scope.", "application_exception": "Reviews with differing scopes, unique original trials and participants remain distinct, as do SMD and MD in mg/dL. Estimates are not added or converted, or extended to product/disease-specific effects, equivalence, optimum doses, medicine replacement, clinical-event prevention or overall safety.", "criterion": "Original records on Preservation of D30, Caution, axes, evidence date and correction must link to reports, trials, denominators, formulations, diseases, LDL scales and timepoints, distinguishing stored information from what remains unverified.", "basis": "Existing principles distinguish formulation, population, comparator, endpoint/scale, timepoint, reports/trials, denominators, overlap, support and harms in the retained LDL record.", "condition_origin": "These existing conditions are linked to the retained LDL question. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: New material, changed conditions and changed verdicts are recorded as separate events after appropriate review. The original date is not reused as a current search or external-reading date. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02" ], "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "The retained Korean and English summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread, with no access attempt.", "observation": "The original D/30/Caution, evidence date 2026-09-08, axes and correction are retained. This is not a new efficacy grade or independent verification.", "condition_status": "Partly verified", "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Material gap: New material, changed conditions and changed verdicts are recorded as separate events after appropriate review. The original date is not reused as a current search or external-reading date.", "uncertainty": "Gaps remain in mixed formulations, diseases, doses, durations, analysis scales, timepoints, denominators, overlap, measurement, missingness, heterogeneity, support and harms. Original numbers, grades and independence narratives do not constitute new calculation, reassessment or clinical validation.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "New material, changed conditions and changed verdicts are recorded as separate events after appropriate review. The original date is not reused as a current search or external-reading date." } ], "reports": [ { "report_id": "R01", "title": "2022 · Updated curcumin and blood-lipid review across mixed diseases/formulations", "url": "https://pubmed.ncbi.nlm.nih.gov/36264280/", "report_type": "Stored description of a systematic review/meta-analysis of RCTs; external methods, searches and inclusion tables remain unread", "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The mixed-disease updated review and type 2 diabetes review remain distinct. Overlap and unique counts of original trials, additional reports and participants, and independent teams, remain unverified. Estimates on different scales are not converted or added, or established as two independent replications.", "independent_replication": "Review reports remain distinct from unique trials, independent teams and participant totals; these are not certified in this work.", "observed_result": "SMD −0.17, 95% CI −0.43~0.09, P=.20", "result_level": "This is the stored standardized LDL difference from a mixed-disease/formulation review. Original analyses, denominators and timepoints remain unverified; it is not converted to mg/dL.", "source_evidence_date": "2026-09-08", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Existing stored summary acquired", "access_status": "Stored summary", "acquired": true, "actually_read": "Stored summary read", "as_of": "2026-10-06T12:26:23.730334+09:00", "qualification": "The stored report/citation summary was read. This does not record possession or full-text reading of the external original article. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "External abstract · Original PubMed link", "public_status": "Original bibliography link only; external content unread", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Only the original PubMed URL is linked. Actual abstract reading, accessibility and bibliographic-content verification remain incomplete. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "External full text · Unacquired/unread", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Original full texts, supplements, included trials and result tables remain unacquired/unread. Abstracts or summaries are not relabeled as full-text reading. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "Review/original-trial registration material", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Actual registration identifiers, contents, amendments and original-trial alignment remain unverified. Prespecification of articles/plans is not certified. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "Protocols and statistical analysis plans", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Original protocols, analysis plans, endpoint hierarchy, timepoints, multiplicity and attrition-handling rules remain unread. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/36264280/" } ] }, { "report_id": "R02", "title": "2022 · Curcumin, lipids and glycemic status review in type 2 diabetes", "url": "https://pubmed.ncbi.nlm.nih.gov/35754684/", "report_type": "Stored description of an RCT meta-analysis in type 2 diabetes; original trials, formulations and analyses remain unverified", "existence": "The information comes from two stored review summaries and bibliographies. Existence/public availability, acquisition and actual reading of external abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The mixed-disease updated review and type 2 diabetes review remain distinct. Overlap and unique counts of original trials, additional reports and participants, and independent teams, remain unverified. Estimates on different scales are not converted or added, or established as two independent replications.", "independent_replication": "Review reports remain distinct from unique trials, independent teams and participant totals; these are not certified in this work.", "observed_result": "MD −4.01 mg/dL, 95% CI −10.96 to 2.95, P=.259; described as null", "result_level": "This is the stored absolute LDL difference from a type 2 diabetes review. It remains distinct from another review's SMD and earlier positive narratives, and is not counted as an independent original trial.", "source_evidence_date": "2026-09-08", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Existing stored summary acquired", "access_status": "Stored summary", "acquired": true, "actually_read": "Stored summary read", "as_of": "2026-10-06T12:26:23.730334+09:00", "qualification": "The stored report/citation summary was read. This does not record possession or full-text reading of the external original article. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "External abstract · Original PubMed link", "public_status": "Original bibliography link only; external content unread", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Only the original PubMed URL is linked. Actual abstract reading, accessibility and bibliographic-content verification remain incomplete. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "External full text · Unacquired/unread", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Original full texts, supplements, included trials and result tables remain unacquired/unread. Abstracts or summaries are not relabeled as full-text reading. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "Review/original-trial registration material", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Actual registration identifiers, contents, amendments and original-trial alignment remain unverified. Prespecification of articles/plans is not certified. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." }, { "material_type": "Protocols and statistical analysis plans", "public_status": "Needed material; existence and public availability unverified", "access_status": "Unread; no access attempt", "acquired": false, "actually_read": "Unread", "as_of": null, "qualification": "Original protocols, analysis plans, endpoint hierarchy, timepoints, multiplicity and attrition-handling rules remain unread. Only stored summaries and bibliographies were read. External abstracts, full texts, registration, protocols/analysis plans, original trials, result tables and support disclosures remain unread. URLs and original narratives alone do not certify existence/public availability, accessibility, acquisition, reading, fulfilled conditions or independence. Original material-specific dates are retained. Stored-summary production timestamps on 2026-10-06 are not external-reading dates; dates for needed external material remain unrecorded. The original evidence date 2026-09-08 remains distinct from actual completed review." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35754684/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "The mixed-disease updated review and type 2 diabetes review remain distinct. Overlap and unique counts of original trials, additional reports and participants, and independent teams, remain unverified. Estimates on different scales are not converted or added, or established as two independent replications." }, "history": [ { "date": "2026-10-24", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "The public view and materials were prepared from the existing 36 items. No new clinical search, verification-state change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-24" }