{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3038-main",
  "verdict_number": "3038",
  "title": "Oral curcumin or curcuminoid supplementation × Body-weight reduction in adults with overweight or obesity",
  "view_version": "1.0",
  "view_created_date": "2026-10-24",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-08",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
  },
  "claim_context": {
    "population": "The retained scope is adults with overweight, obesity or obesity-related metabolic disease. Original-trial eligibility, diseases, baseline BMI/weight, population contributions and direct effects remain unverified.",
    "intervention": "The evidence mixes conventional and bioavailability-enhanced oral curcumin/curcuminoid formulations. Piperine combinations and other products, carriers and routes remain distinct; products, content, classifications, contributions and direct effects remain unverified.",
    "dose": "The original record describes varied trial-specific doses without an established single optimum. Actual mg/day, frequency, active amounts, adherence and direct dose response remain unverified; individual recommended doses are not assigned.",
    "comparator": "The retained comparator is placebo or control management. Product-specific placebo, lifestyle measures, concomitant obesity/metabolic treatment, shared care and medicine changes remain incompletely verified; combined effects are not assigned to curcumin alone.",
    "endpoint": "The selected endpoint is body-weight change in kg. BMI, waist circumference and body fat remain distinct; change/final-value definitions, measurement, denominators, timepoints and importance remain separately unverified. Results are not converted into other endpoints or individual percentage weight loss.",
    "duration": "The record describes weeks to months across original trials. Duration distributions, actual weight-measurement/extraction timepoints, longer-term maintenance and persistence after discontinuation remain unverified.",
    "excluded_extensions": [
      "The selected question concerns mixed oral curcumin formulations and body weight in kg in adults with overweight, obesity or related metabolic disease. Individual products, piperine combinations, other routes, BMI/waist/body fat and obesity-treatment replacement are different direct questions.",
      "The original C/54/Caution and B/S/R2/I2/E~/B2/C0 are retained. Historical independence/cross-checking and generic English verification wording are not inherited as current original-source reading, formal assessment or independent clinical validation.",
      "The overall MD −0.59 kg, 95% CI −0.81 to −0.36 is retained. A pooled mean does not establish guaranteed loss for every product/person or a prediction interval for individual products/future trials.",
      "The enhanced-formulation −0.80 kg and interval −1.38 to −0.23 are subgroup records. Confidence-level details, contributing denominators and direct formulation comparisons remain unverified; subtraction from the overall estimate does not generate additional loss or superiority.",
      "The 14 reviews, 50 RCTs, 21 high-risk trials and 42% are original descriptions. Overlap among reviews, reports, trials, participants and teams remains distinct; unique counts, independent replication and proportions are not newly added or recalculated.",
      "PROSPERO CRD42022321112 and the preregistration/nongovernmental-support descriptions are retained without promotion to actual registration/plan reading or verified funders, product support, employee authorship, conflicts or independence.",
      "The original mean below 1 kg and below-clinical-threshold interpretation are retained. Threshold definitions, patient importance, weight-loss maintenance and long-term/high-dose/formulation-specific harms remain unverified; new clinical thresholds, percentage loss, optimum doses and overall safety are not established.",
      "The original evidence date 2026-09-08, correction of 1 English field on 2026-09-14 and authorship date 2026-10-06 remain distinct. Authorship timestamps and dated stored notes are not actual external-reading/completed-content-review dates; review dates remain unrecorded."
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which curcumin preparation and body-weight question are addressed?",
      "needed": "Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope",
      "role": "Required",
      "role_reason": "Material on Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Meta-analysis eligibility/question definitions and original-trial lists. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original claim concerns reduced body weight in kg in adults with overweight or obesity. The retained meta-analysis summary mixes conventional and enhanced formulations.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Review of the independent-claim boundary remains incomplete, and subsidiary-claim records are empty.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Meta-analysis eligibility/question definitions and original-trial lists"
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What are the conventional and bioavailability-enhanced formulations?",
      "needed": "Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification",
      "role": "Required",
      "role_reason": "Material on Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific product/composition/content tables and formulation contributions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained use conditions describe conventional and bioavailability-enhanced oral formulations, with piperine combinations kept separate.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Individual product names, curcuminoid contents, nano/micellar/phytosome classifications and actual included formulations remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial-specific product/composition/content tables and formulation contributions"
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "How are piperine, diet and exercise combination effects distinguished?",
      "needed": "Separating curcumin alone from absorption-enhancer/lifestyle combinations",
      "role": "Required",
      "role_reason": "Material on Separating curcumin alone from absorption-enhancer/lifestyle combinations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating curcumin alone from absorption-enhancer/lifestyle combinations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific composition, accompanying diet/exercise and shared-care tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original keeps piperine combinations separate and warns against assigning piperine, diet or exercise combination effects to curcumin alone.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Trial-specific piperine, lifestyle measures, other ingredients and interventions shared by both arms remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial-specific composition, accompanying diet/exercise and shared-care tables"
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are oral supplementation, turmeric and topical oral products the same intervention?",
      "needed": "Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations",
      "role": "Required",
      "role_reason": "Material on Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original trials using the same product and route. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original intervention is oral curcumin/curcuminoid supplementation. It warns against treating products as interchangeable.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Direct body-weight effects of ordinary turmeric powder, foods, rinses, gels or particular formulations remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original trials using the same product and route"
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were overweight, obesity and metabolic-disease populations distinguished?",
      "needed": "Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight",
      "role": "Required",
      "role_reason": "Material on Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Included-study populations/baseline characteristics and eligibility criteria. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained use conditions describe adults with overweight, obesity or obesity-related metabolic disease. The original claim concerns body weight in kg in adults with overweight or obesity.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Trial-specific diseases, eligibility, baseline body weight/BMI and population-subgroup contributions remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Included-study populations/baseline characteristics and eligibility criteria"
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What doses were used, and is an optimum established?",
      "needed": "Trial-specific administered doses, constituent content, frequency and adherence",
      "role": "Required",
      "role_reason": "Material on Trial-specific administered doses, constituent content, frequency and adherence is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific administered doses, constituent content, frequency and adherence must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial administration/constituent-content tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original dose record states that doses varied across trials and no single optimum was established.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Trial-specific mg/day, administration frequency, curcuminoid content, adherence and direct dose-specific effects remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial administration/constituent-content tables"
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Which weight results across weeks to months were pooled?",
      "needed": "Trial-specific treatment duration, measurement visits and end/follow-up timepoints",
      "role": "Required",
      "role_reason": "Material on Trial-specific treatment duration, measurement visits and end/follow-up timepoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific treatment duration, measurement visits and end/follow-up timepoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific visits/durations, follow-up and extraction-timepoint tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original duration is weeks to months, varying by trial.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "The duration distribution, body-weight measurement timepoints, final-value/change-score selection and persistence after discontinuation remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial-specific visits/durations, follow-up and extraction-timepoint tables"
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What did placebo or control management involve?",
      "needed": "Comparator, shared treatment, lifestyle management and differences between arms",
      "role": "Required",
      "role_reason": "Material on Comparator, shared treatment, lifestyle management and differences between arms is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Comparator, shared treatment, lifestyle management and differences between arms must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial comparator/shared-management tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original comparator is placebo or control management.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Trial-specific placebo/management types, concomitant obesity treatment and care shared by both arms remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial comparator/shared-management tables"
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "How are changes in diet, exercise and medicines distinguished from curcumin?",
      "needed": "Diet/exercise, weight-management/metabolic medicines, cointerventions and changes",
      "role": "Required",
      "role_reason": "Material on Diet/exercise, weight-management/metabolic medicines, cointerventions and changes is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Diet/exercise, weight-management/metabolic medicines, cointerventions and changes must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific concomitant-treatment, lifestyle and metabolic-medicine records. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original explanation describes diverse products, populations and accompanying lifestyle measures.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Arm-specific diet, exercise, medicine changes and handling of confounding/imbalance remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial-specific concomitant-treatment, lifestyle and metabolic-medicine records"
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Is body weight in kg the same outcome as BMI, waist circumference or body fat?",
      "needed": "Separating weight change in kg from other anthropometric endpoints",
      "role": "Required",
      "role_reason": "Material on Separating weight change in kg from other anthropometric endpoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating weight change in kg from other anthropometric endpoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Endpoint-specific definitions, units and extracted results. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original principal endpoint is body-weight change in kg. The supplementary explanation keeps BMI, waist circumference and body fat separate.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Weight measurement/change definitions, other endpoint-specific results and contributing counts remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Endpoint-specific definitions, units and extracted results"
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What are the overall weight estimate and interval?",
      "needed": "Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints",
      "role": "Required",
      "role_reason": "Material on Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Body-weight forest plot, extraction table, denominators/timepoints and analysis methods. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained overall body-weight result is MD −0.59 kg, 95% CI −0.81 to −0.36.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Individual contributing trial effects, participant denominators, timepoints and final-value/change definitions remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Body-weight forest plot, extraction table, denominators/timepoints and analysis methods"
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What is the scope of the enhanced-formulation −0.80 kg result?",
      "needed": "Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration",
      "role": "Required",
      "role_reason": "Material on Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Enhanced-formulation classification, subgroup forest plot, denominators and analysis plan. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original result also records enhanced formulations at −0.80 kg, interval −1.38 to −0.23; the reader answer also describes 0.80 kg.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Which enhanced formulations/participants contributed, contributing trial counts, interval calculation/confidence-level details and subgroup plans remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Enhanced-formulation classification, subgroup forest plot, denominators and analysis plan"
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Is this direct evidence that enhanced formulations outperform conventional forms?",
      "needed": "Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions",
      "role": "Required",
      "role_reason": "Material on Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct formulation-comparison studies and subgroup comparison plans/tests. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original records the overall pooled value and enhanced-formulation subgroup value, without a direct between-formulation comparison estimate.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Direct conventional-versus-enhanced comparisons, subgroup interaction and control of population/duration differences remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct formulation-comparison studies and subgroup comparison plans/tests"
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What can this table establish about BMI?",
      "needed": "BMI units, measurement timepoints, contributing trials and effects/intervals",
      "role": "Required",
      "role_reason": "Material on BMI units, measurement timepoints, contributing trials and effects/intervals is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on BMI units, measurement timepoints, contributing trials and effects/intervals must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate BMI results/forest plot and definitions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original supplementary explanation keeps BMI separate from the weight-in-kg verdict.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "BMI effects, intervals, contributing trials/denominators and timepoints remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate BMI results/forest plot and definitions"
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "How is waist circumference retained as a separate outcome?",
      "needed": "Waist-circumference units, measurement sites, timepoints and effects/intervals",
      "role": "Required",
      "role_reason": "Material on Waist-circumference units, measurement sites, timepoints and effects/intervals is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Waist-circumference units, measurement sites, timepoints and effects/intervals must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate waist-circumference definitions/results and contribution lists. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original supplementary explanation separates waist circumference from the weight-in-kg verdict.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Waist values, measurement procedures and contributing trials/denominators remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate waist-circumference definitions/results and contribution lists"
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Can the weight estimate stand in for body-fat reduction?",
      "needed": "Body-fat measurement methods, units, denominators, timepoints and effects",
      "role": "Required",
      "role_reason": "Material on Body-fat measurement methods, units, denominators, timepoints and effects is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Body-fat measurement methods, units, denominators, timepoints and effects must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate body-fat measurement/effect tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original supplementary explanation keeps body fat separate from body weight in kg.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Body-fat values, measurement techniques, contributing trials/denominators and timepoints remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate body-fat measurement/effect tables"
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What counts are the 14 meta-analyses and 50 RCTs?",
      "needed": "Separating umbrella reviews, updated RCTs and endpoint-specific contributions",
      "role": "Required",
      "role_reason": "Material on Separating umbrella reviews, updated RCTs and endpoint-specific contributions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating umbrella reviews, updated RCTs and endpoint-specific contributions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Lists of the 14 reviews/50 trials, overlap relationships and endpoint contributions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original research description refers to 14 existing meta-analyses and an updated search identifying 50 RCTs with weight-in-kg results. The evidence sample description is 50 RCTs; 21 at high risk.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Original inclusion lists, overlap between updated/existing material, weight-contributing trial lists and inclusion relationships among meta-analyses remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Lists of the 14 reviews/50 trials, overlap relationships and endpoint contributions"
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "How many participants were randomized, analyzed and completed across 50 trials?",
      "needed": "Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators",
      "role": "Required",
      "role_reason": "Material on Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial flow, denominators and meta-analysis contributing-participant tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The current sample description records only 50 trials and 21 at high risk.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Unique participant totals, arm/trial-specific randomized, analyzed and completed counts, and body-weight/enhanced-formulation denominators remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial flow, denominators and meta-analysis contributing-participant tables"
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Did the same trial recur across reviews and papers?",
      "needed": "Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships",
      "role": "Required",
      "role_reason": "Material on Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Relationships among included trials, reports and registrations. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The source retains 1 umbrella-review/updated-meta-analysis report.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Multiple papers from the same trial, participant overlap, overlap among the 14 reviews and subgroup overlap remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Relationships among included trials, reports and registrations"
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "When and how far did the updated search extend?",
      "needed": "Search date, databases, strategies, registration/unpublished material and formulation/population eligibility",
      "role": "Required",
      "role_reason": "Material on Search date, databases, strategies, registration/unpublished material and formulation/population eligibility is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Search date, databases, strategies, registration/unpublished material and formulation/population eligibility must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Meta-analysis search strategies, eligibility, selection flow and search dates. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original mentions an umbrella review and updated searching.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "The actual search cutoff, databases/strategies, unpublished-material searching, language/formulation restrictions and selection flow remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Meta-analysis search strategies, eligibility, selection flow and search dates"
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Which original-trial weight values were extracted, and how?",
      "needed": "Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection",
      "role": "Required",
      "role_reason": "Material on Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Body-weight extraction, original result tables and analysis-code explanation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained use conditions describe body-weight change in kg; the evidence records body weight in kg and pooled MD.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Original/final/change/adjusted-value choices, timepoint selection, multi-arm handling, SD/missing-data extraction and unit conversion remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Body-weight extraction, original result tables and analysis-code explanation"
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How were MD and between-study heterogeneity estimated?",
      "needed": "Pooling model, weights, heterogeneity, prediction intervals and subgroups",
      "role": "Required",
      "role_reason": "Material on Pooling model, weights, heterogeneity, prediction intervals and subgroups is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Pooling model, weights, heterogeneity, prediction intervals and subgroups must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Statistical methods, forest plot, heterogeneity/prediction intervals and subgroup plans. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original result records MD and intervals; its explanation describes diversity in products, populations and lifestyles.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Fixed/random models, weights, I²/τ², prediction intervals and heterogeneity exploration remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Statistical methods, forest plot, heterogeneity/prediction intervals and subgroup plans"
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What are the 21 high-risk trials and original 42% description?",
      "needed": "Trial-specific risk assessment, tools/domains and contribution weights",
      "role": "Required",
      "role_reason": "Material on Trial-specific risk assessment, tools/domains and contribution weights is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific risk assessment, tools/domains and contribution weights must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original risk-assessment tables, tools and endpoint links. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The evidence sample description records 21 trials at high risk of bias; the key-point description refers to 21 trials, and the grade rationale describes 42% of original trials as high risk.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Which 21 trials, assessment tools/domains/procedures, weight-outcome contributions and sensitivity analyses remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original risk-assessment tables, tools and endpoint links"
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "What were trial-specific randomization, masking and effects of interest?",
      "needed": "Trial-specific allocation/concealment, masking, effects of interest and baseline balance",
      "role": "Required",
      "role_reason": "Material on Trial-specific allocation/concealment, masking, effects of interest and baseline balance is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific allocation/concealment, masking, effects of interest and baseline balance must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial methods and allocation/analysis tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original design is described as a meta-analysis of RCTs.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Randomization/concealment, masking, ITT/PP, baseline balance and endpoint limitations across the 50 trials remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial methods and allocation/analysis tables"
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How were attrition, nonadherence and missing weight measurements handled?",
      "needed": "Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators",
      "role": "Required",
      "role_reason": "Material on Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial flow, adherence and missing-data/sensitivity tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The current summary does not contain trial-specific attrition, adherence or missing-data information.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Trial-specific missingness, reasons, handling, deviations/adherence, sensitivity analyses and their incorporation into the meta-analysis remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial flow, adherence and missing-data/sensitivity tables"
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "What are the results for high-risk/small trials and publication bias?",
      "needed": "High-risk exclusions, small studies, missing/publication bias and influence analyses",
      "role": "Required",
      "role_reason": "Material on High-risk exclusions, small studies, missing/publication bias and influence analyses is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on High-risk exclusions, small studies, missing/publication bias and influence analyses must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Sensitivity/influence, missing-report and publication-bias material. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The source describes 21 high-risk trials alongside a small pooled effect.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Results excluding high-risk trials, leave-one-out analyses, small-study/publication bias and effects of missing trials remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Sensitivity/influence, missing-report and publication-bias material"
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Do PROSPERO plans correspond to weight/subgroup analyses?",
      "needed": "Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments",
      "role": "Required",
      "role_reason": "Material on Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: PROSPERO content/history, plans and analysis lists. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained design describes a preregistered umbrella review/meta-analysis; funding/bibliography record PROSPERO CRD42022321112.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "PROSPERO content/registration dates, plan amendments, planned analyses/endpoint hierarchy and multiplicity remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "PROSPERO content/history, plans and analysis lists"
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are the statistical signal and clinical meaning of 0.59 kg the same?",
      "needed": "Effects/intervals, original interpretation, patient importance, baseline weight and persistence",
      "role": "Required",
      "role_reason": "Material on Effects/intervals, original interpretation, patient importance, baseline weight and persistence is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Effects/intervals, original interpretation, patient importance, baseline weight and persistence must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Prespecified clinical importance, baseline/maintenance and patient-important outcomes. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original reader answer describes a statistical signal without large weight loss. Its key-point description states that the mean is below 1 kg, and the grade rationale says it falls below a clinical threshold.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "The original threshold's definition/basis, population-specific importance, weight-loss maintenance and patient-important outcomes remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Prespecified clinical importance, baseline/maintenance and patient-important outcomes"
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is retained here from the original independence narrative?",
      "needed": "Unique trials/teams, question/formulation correspondence and overlap among meta-analyses",
      "role": "Required",
      "role_reason": "Material on Unique trials/teams, question/formulation correspondence and overlap among meta-analyses is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Unique trials/teams, question/formulation correspondence and overlap among meta-analyses must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial families, teams/support relationships and exact formulation/endpoint lists. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original counterview describes recurring reduction directions across independent trials/umbrella review. The original R2/I2 axes are retained.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Team independence, direct replication with the same formulation, unique trials/participant counts and meta-analysis independence remain unverified in this externally unread scope.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial families, teams/support relationships and exact formulation/endpoint lists"
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are PMID, DOI, PROSPERO and the stored summary distinguished?",
      "needed": "Original-report bibliography, registration wording, external-unread scope and stored JSON",
      "role": "Required",
      "role_reason": "Material on Original-report bibliography, registration wording, external-unread scope and stored JSON is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original-report bibliography, registration wording, external-unread scope and stored JSON must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Articles, registration and supplementary/original-trial material corresponding to the citation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original citation is Unhapipatpong et al., Am J Clin Nutr.2023;117:1005-1016, PMID36898635, DOI10.1016/j.ajcnut.2023.03.006, PROSPERO CRD42022321112. The material read is the stored JSON.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "External article abstracts/full texts, PROSPERO, original trials and related original material remain unread, with no access attempt.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Articles, registration and supplementary/original-trial material corresponding to the citation"
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "What are the nongovernmental support and product/author roles?",
      "needed": "Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles",
      "role": "Required",
      "role_reason": "Material on Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original meta-analysis/trial funding, conflict, author and product-support disclosures. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained funding description records nongovernmental research support; PROSPERO CRD42022321112.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Supporting institutions/amounts, product support, employee authorship, conflicts and support roles in individual original trials remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original meta-analysis/trial funding, conflict, author and product-support disclosures"
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "How do original dates differ from the preparation timestamp?",
      "needed": "Original evidence date, correction date, meta-analysis publication/search and preparation timestamp",
      "role": "Required",
      "role_reason": "Material on Original evidence date, correction date, meta-analysis publication/search and preparation timestamp is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original evidence date, correction date, meta-analysis publication/search and preparation timestamp must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original search, receipt, publication and amendment-event records. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original evidence date is 2026-09-08; the English correction is dated 2026-09-14. The meta-analysis bibliography is dated 2023.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Actual original-meta-analysis search dates, current external-reading dates and completed latest-search dates remain unverified/unrecorded.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original search, receipt, publication and amendment-event records"
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "How are generic English wording and the 1-field correction retained?",
      "needed": "Korean/English results, generic English evidence wording and before/after correction records",
      "role": "Required",
      "role_reason": "Material on Korean/English results, generic English evidence wording and before/after correction records is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Korean/English results, generic English evidence wording and before/after correction records must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Complete before/after English-correction originals and result translation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The English reader answer records 0.59/0.80 kg. Generic explanations remain in English sample, funding, endpoint, result and evidence-weight fields; the correction describes changing 1 field.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Which field changed, its before/after values and detailed numerical/original-source correspondence in English still await review.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete before/after English-correction originals and result translation"
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "What is the role of C54, historical cross-checking and axes here?",
      "needed": "Original grade, score, safety, axes, grade decision and empty values",
      "role": "Required",
      "role_reason": "Material on Original grade, score, safety, axes, grade decision and empty values is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original grade, score, safety, axes, grade decision and empty values must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The original verdict and subsequent authorized correction events. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original C54/Caution, B/S/R2/I2/E~/B2/C0 axes and historical independent Codex cross-check wording are preserved in the source.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Current content review, new clinical validation and methodology certification remain incomplete.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The original verdict and subsequent authorized correction events"
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "For which events and denominators were gastrointestinal complaints reported?",
      "needed": "Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration",
      "role": "Required",
      "role_reason": "Material on Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial adverse events/discontinuations, collection and arm-specific harm tables. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The retained safety wording describes gastrointestinal complaints as the main issue in short trials.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Event types, arm-specific event/person counts, harm denominators, collection/discontinuation and original-trial durations remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-trial adverse events/discontinuations, collection and arm-specific harm tables"
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "What is known about formulation-specific safety beyond short-term use?",
      "needed": "Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions",
      "role": "Supplementary; required when extending safety scope",
      "role_reason": "Material on Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Longer follow-up, formulation/dose-specific harms and interaction material. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The original safety wording states that long-term/high-dose safety and medicine interactions are not adequately established by formulation.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Original material on formulation-specific long-term/rare harms, high doses, vulnerable groups and actual interactions remains unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Longer follow-up, formulation/dose-specific harms and interaction material"
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Are harm timing, comparisons, alternative causes and independent cases available?",
      "needed": "Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families",
      "role": "Supplementary; required for harm causality/replication scope",
      "role_reason": "Material on Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Individual-event timing, concomitant/alternative explanations, between-group harms and unique-case material. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The current manuscript retains only general short-term gastrointestinal/long-term interaction precautions.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Individual event timing, causality/alternative causes, between-group risks, independent harm cases and report families remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Individual-event timing, concomitant/alternative explanations, between-group harms and unique-case material"
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Does enhanced bioavailability cause the weight effect?",
      "needed": "Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations",
      "role": "Supplementary; required for mechanism/formulation-superiority claims",
      "role_reason": "Material on Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Formulation-specific exposure/absorption and direct clinical outcomes. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The source records the enhanced-formulation weight subgroup value and warns against product interchangeability.",
      "condition_status": "Unverified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Absorption measurement, relationships between absorption changes and weight, direct formulation comparisons and causal mechanisms remain unverified.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Formulation-specific exposure/absorption and direct clinical outcomes"
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "How are the stored summary and unread materials connected?",
      "needed": "Material-specific acquisition/reading, original citation links and condition/evidence-change events",
      "role": "Required",
      "role_reason": "Material on Material-specific acquisition/reading, original citation links and condition/evidence-change events is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Material-specific acquisition/reading, original citation links and condition/evidence-change events must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original material/corrections supplied or separately authorized. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "The retained Korean and English summary and bibliography were read. External abstracts, full texts, PROSPERO, original-trial, extraction, analysis, harm and support material remain unread, with no access attempt.",
      "observation": "The full stored JSON was read for preparation, with the original PubMed citation URL retained. External material remains unread, with no access attempt.",
      "condition_status": "Partly verified",
      "status_reason": "Information in stored summaries is linked to gaps in detailed material. External verification and content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.",
      "missingness": "Full texts, PROSPERO, original-trial, extraction, statistical, harm and support material remain unverified; content review remains incomplete.",
      "uncertainty": "Gaps remain in product/population/dose/duration-specific direct effects, pooled/subgroup analyses, denominators, overlap, measurement, missingness, heterogeneity, importance, harms and support. Original numbers, grades and historical independence narratives do not constitute new calculation, reassessment or clinical validation.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original material/corrections supplied or separately authorized"
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "2023 · Curcumin and body weight: umbrella review and updated meta-analysis",
      "url": "https://pubmed.ncbi.nlm.nih.gov/36898635/",
      "report_type": "Stored description of a preregistered umbrella review/updated RCT meta-analysis; actual registration, inclusion tables and methods remain externally unverified",
      "existence": "The information comes from the stored umbrella-review/updated-meta-analysis summary and bibliography. Existence/public availability, acquisition and reading of external articles, registration, inclusion lists, original trials, extraction, analysis, harm and support material remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts/full texts, registration and original trials unread, with no access attempt",
      "study_family": "SF01-Unhapipatpong-2023-weight-synthesis-native",
      "independent_replication": "Original independence narrative retained; no unique-trial, team or participant count certified here",
      "observed_result": "MD −0.59 kg, 95% CI −0.81 to −0.36; enhanced formulations −0.80 kg, interval −1.38 to −0.23",
      "result_level": "These are overall pooled weight and enhanced-formulation subgroup values. Weight/BMI/waist/body fat, reviews/trials/participants and contributing denominators remain distinct; original articles, registration, analyses, support and harm material remain unread.",
      "source_evidence_date": "2026-09-08",
      "materials": [
        {
          "material_type": "Stored meta-analysis summary",
          "public_status": "Existing stored summary acquired",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Stored summary read",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Only the stored summary was read for preparation. This is not actual acquisition/reading of the meta-analysis full text/original trials or clinical validation. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "External article identity link · Original PubMed citation",
          "public_status": "Original bibliography link only; external content unread",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "PMID36898635, DOI10.1016/j.ajcnut.2023.03.006 and the original PubMed link are stored identifiers. Successful access, acquisition and actual reading of the page/abstract were not verified. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "External full text · Umbrella review/updated meta-analysis",
          "public_status": "Original bibliography link only; external content unread",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "A bibliographic link is not promoted to full-text public availability, acquisition or reading. Original analyses, methods and supplements remain unread. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Registration material · PROSPERO CRD42022321112",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "PROSPERO CRD42022321112 is the retained registration identifier. Registration content, timing, amendments and weight/subgroup correspondence remain unread; prospective registration of individual trials is not certified. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Review/trial/report-family contributions · 14 reviews/50 trials",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Inclusion, overlap, report families and endpoint contributions of the 14 reviews/50 trials remain unverified. Participant, unique-trial and independent-team totals are not newly generated. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Endpoint extraction/denominators/results · Weight/enhanced formulations/BMI/waist/body fat",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Actual extraction, denominators, timepoints and results for weight, enhanced formulations, BMI, waist and body fat remain unverified. The confidence level of the enhanced-formulation interval is not assumed, and other endpoints are not substituted. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Pooling methods, risk assessment, sensitivity and missing/publication bias",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "The 21 high-risk trials and 42% are original descriptions. Risk tables/tools, weights, heterogeneity, sensitivity and missing/publication bias remain unverified; no recalculation or formal-method execution was performed. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Products, formulations, doses, populations, duration and lifestyle/concomitant care",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Products, contents, carriers, doses, populations, durations and both arms’ lifestyle/concomitant medicines remain incompletely verified. Piperine/lifestyle combination effects are not assigned to curcumin alone. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Harms, discontinuation, long-term/high-dose use and formulation-specific interactions",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Original gastrointestinal, long-term/high-dose and interaction precautions are retained. Actual event definitions, collection, arm-specific harms, denominators, causality and rare harms remain unverified; absence of events and overall safety are not established. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        },
        {
          "material_type": "Original funding, conflict and product-support disclosures",
          "public_status": "Needed material; existence and public availability unverified",
          "access_status": "Unread; no access attempt",
          "acquired": false,
          "actually_read": "Unread",
          "as_of": "2026-09-08 (original evidence date; not external reading)",
          "qualification": "Nongovernmental support remains distinct from the PROSPERO identifier. Original meta-analysis/trial funder, product-support, employee-authorship, role and conflict disclosures remain unread; independence and noninvolvement are not certified. Only the stored summary/original bibliography was read. External abstracts, full texts, PROSPERO, inclusion tables, original-trial, extraction, analysis, harm and support material remain unread. URLs, identifiers and original narratives alone do not certify existence/public availability, acquisition, reading, prespecification, independence or fulfilled conditions. The 2026-09-08 date recorded for materials is the original evidence date, not an external-reading date. Authorship timestamps on 2026-10-06 are preparation records, not completed-content-review/external-verification dates. Actual review/verification dates remain unrecorded."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/36898635/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The stored umbrella-review/updated report remains distinct from original trials, reviews, reports and participants. Overlap, unique trials/participants and team independence remain unverified; the original independence narrative is not converted into new counts or certification."
  },
  "history": [
    {
      "date": "2026-10-24",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "The public view and materials were prepared from the existing 39 items. No new clinical search, verification-state change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-24"
}