{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Oral curcumin or curcuminoid supplementation × Body-weight reduction in adults with overweight or obesity",
  "language": "en",
  "translation_date": "2026-10-24",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which curcumin preparation and body-weight question are addressed?",
      "needed": "Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope",
      "role": "Required",
      "role_reason": "Material on Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Oral curcumin, population, body weight in kg, comparison and weeks-to-months scope must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Meta-analysis eligibility/question definitions and original-trial lists. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What are the conventional and bioavailability-enhanced formulations?",
      "needed": "Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification",
      "role": "Required",
      "role_reason": "Material on Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Curcuma longa-derived curcumin/curcuminoids and oral-formulation classification must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific product/composition/content tables and formulation contributions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "How are piperine, diet and exercise combination effects distinguished?",
      "needed": "Separating curcumin alone from absorption-enhancer/lifestyle combinations",
      "role": "Required",
      "role_reason": "Material on Separating curcumin alone from absorption-enhancer/lifestyle combinations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating curcumin alone from absorption-enhancer/lifestyle combinations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific composition, accompanying diet/exercise and shared-care tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are oral supplementation, turmeric and topical oral products the same intervention?",
      "needed": "Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations",
      "role": "Required",
      "role_reason": "Material on Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Distinguishing swallowed supplements from conventional turmeric, topical products and special formulations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original trials using the same product and route. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were overweight, obesity and metabolic-disease populations distinguished?",
      "needed": "Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight",
      "role": "Required",
      "role_reason": "Material on Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific weight status, obesity-related metabolic disease and baseline BMI/body weight must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Included-study populations/baseline characteristics and eligibility criteria. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What doses were used, and is an optimum established?",
      "needed": "Trial-specific administered doses, constituent content, frequency and adherence",
      "role": "Required",
      "role_reason": "Material on Trial-specific administered doses, constituent content, frequency and adherence is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific administered doses, constituent content, frequency and adherence must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial administration/constituent-content tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Which weight results across weeks to months were pooled?",
      "needed": "Trial-specific treatment duration, measurement visits and end/follow-up timepoints",
      "role": "Required",
      "role_reason": "Material on Trial-specific treatment duration, measurement visits and end/follow-up timepoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific treatment duration, measurement visits and end/follow-up timepoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific visits/durations, follow-up and extraction-timepoint tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What did placebo or control management involve?",
      "needed": "Comparator, shared treatment, lifestyle management and differences between arms",
      "role": "Required",
      "role_reason": "Material on Comparator, shared treatment, lifestyle management and differences between arms is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Comparator, shared treatment, lifestyle management and differences between arms must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial comparator/shared-management tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "How are changes in diet, exercise and medicines distinguished from curcumin?",
      "needed": "Diet/exercise, weight-management/metabolic medicines, cointerventions and changes",
      "role": "Required",
      "role_reason": "Material on Diet/exercise, weight-management/metabolic medicines, cointerventions and changes is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Diet/exercise, weight-management/metabolic medicines, cointerventions and changes must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Trial-specific concomitant-treatment, lifestyle and metabolic-medicine records. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Is body weight in kg the same outcome as BMI, waist circumference or body fat?",
      "needed": "Separating weight change in kg from other anthropometric endpoints",
      "role": "Required",
      "role_reason": "Material on Separating weight change in kg from other anthropometric endpoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating weight change in kg from other anthropometric endpoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Endpoint-specific definitions, units and extracted results. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What are the overall weight estimate and interval?",
      "needed": "Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints",
      "role": "Required",
      "role_reason": "Material on Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Body-weight MD in kg, 95% CI, contributing trials/denominators and measurement timepoints must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Body-weight forest plot, extraction table, denominators/timepoints and analysis methods. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What is the scope of the enhanced-formulation −0.80 kg result?",
      "needed": "Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration",
      "role": "Required",
      "role_reason": "Material on Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Enhanced-formulation classification, contributing counts, MD, interval, population/dose/duration must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Enhanced-formulation classification, subgroup forest plot, denominators and analysis plan. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Is this direct evidence that enhanced formulations outperform conventional forms?",
      "needed": "Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions",
      "role": "Required",
      "role_reason": "Material on Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Direct randomized comparisons between formulations, interaction tests and shared population/dose conditions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct formulation-comparison studies and subgroup comparison plans/tests. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What can this table establish about BMI?",
      "needed": "BMI units, measurement timepoints, contributing trials and effects/intervals",
      "role": "Required",
      "role_reason": "Material on BMI units, measurement timepoints, contributing trials and effects/intervals is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on BMI units, measurement timepoints, contributing trials and effects/intervals must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate BMI results/forest plot and definitions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "How is waist circumference retained as a separate outcome?",
      "needed": "Waist-circumference units, measurement sites, timepoints and effects/intervals",
      "role": "Required",
      "role_reason": "Material on Waist-circumference units, measurement sites, timepoints and effects/intervals is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Waist-circumference units, measurement sites, timepoints and effects/intervals must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate waist-circumference definitions/results and contribution lists. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Can the weight estimate stand in for body-fat reduction?",
      "needed": "Body-fat measurement methods, units, denominators, timepoints and effects",
      "role": "Required",
      "role_reason": "Material on Body-fat measurement methods, units, denominators, timepoints and effects is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Body-fat measurement methods, units, denominators, timepoints and effects must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate body-fat measurement/effect tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What counts are the 14 meta-analyses and 50 RCTs?",
      "needed": "Separating umbrella reviews, updated RCTs and endpoint-specific contributions",
      "role": "Required",
      "role_reason": "Material on Separating umbrella reviews, updated RCTs and endpoint-specific contributions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Separating umbrella reviews, updated RCTs and endpoint-specific contributions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Lists of the 14 reviews/50 trials, overlap relationships and endpoint contributions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "How many participants were randomized, analyzed and completed across 50 trials?",
      "needed": "Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators",
      "role": "Required",
      "role_reason": "Material on Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Overall/trial-specific randomized, analyzed, completed and endpoint/subgroup denominators must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial flow, denominators and meta-analysis contributing-participant tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Did the same trial recur across reviews and papers?",
      "needed": "Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships",
      "role": "Required",
      "role_reason": "Material on Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original-trial IDs, multiple reports, follow-up/registration and review inclusion relationships must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Relationships among included trials, reports and registrations. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "When and how far did the updated search extend?",
      "needed": "Search date, databases, strategies, registration/unpublished material and formulation/population eligibility",
      "role": "Required",
      "role_reason": "Material on Search date, databases, strategies, registration/unpublished material and formulation/population eligibility is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Search date, databases, strategies, registration/unpublished material and formulation/population eligibility must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Meta-analysis search strategies, eligibility, selection flow and search dates. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Which original-trial weight values were extracted, and how?",
      "needed": "Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection",
      "role": "Required",
      "role_reason": "Material on Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Final/change values, kg units, multiple timepoints, multiple arms, adjustment and duplicate selection must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Body-weight extraction, original result tables and analysis-code explanation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How were MD and between-study heterogeneity estimated?",
      "needed": "Pooling model, weights, heterogeneity, prediction intervals and subgroups",
      "role": "Required",
      "role_reason": "Material on Pooling model, weights, heterogeneity, prediction intervals and subgroups is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Pooling model, weights, heterogeneity, prediction intervals and subgroups must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Statistical methods, forest plot, heterogeneity/prediction intervals and subgroup plans. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What are the 21 high-risk trials and original 42% description?",
      "needed": "Trial-specific risk assessment, tools/domains and contribution weights",
      "role": "Required",
      "role_reason": "Material on Trial-specific risk assessment, tools/domains and contribution weights is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific risk assessment, tools/domains and contribution weights must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original risk-assessment tables, tools and endpoint links. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "What were trial-specific randomization, masking and effects of interest?",
      "needed": "Trial-specific allocation/concealment, masking, effects of interest and baseline balance",
      "role": "Required",
      "role_reason": "Material on Trial-specific allocation/concealment, masking, effects of interest and baseline balance is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Trial-specific allocation/concealment, masking, effects of interest and baseline balance must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial methods and allocation/analysis tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How were attrition, nonadherence and missing weight measurements handled?",
      "needed": "Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators",
      "role": "Required",
      "role_reason": "Material on Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Arm-specific attrition, adherence, missing-data handling and weight-analysis denominators must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial flow, adherence and missing-data/sensitivity tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "What are the results for high-risk/small trials and publication bias?",
      "needed": "High-risk exclusions, small studies, missing/publication bias and influence analyses",
      "role": "Required",
      "role_reason": "Material on High-risk exclusions, small studies, missing/publication bias and influence analyses is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on High-risk exclusions, small studies, missing/publication bias and influence analyses must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Sensitivity/influence, missing-report and publication-bias material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Do PROSPERO plans correspond to weight/subgroup analyses?",
      "needed": "Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments",
      "role": "Required",
      "role_reason": "Material on Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Registration content, dated plans, body weight/BMI/waist/enhanced formulations and amendments must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: PROSPERO content/history, plans and analysis lists. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Are the statistical signal and clinical meaning of 0.59 kg the same?",
      "needed": "Effects/intervals, original interpretation, patient importance, baseline weight and persistence",
      "role": "Required",
      "role_reason": "Material on Effects/intervals, original interpretation, patient importance, baseline weight and persistence is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Effects/intervals, original interpretation, patient importance, baseline weight and persistence must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Prespecified clinical importance, baseline/maintenance and patient-important outcomes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is retained here from the original independence narrative?",
      "needed": "Unique trials/teams, question/formulation correspondence and overlap among meta-analyses",
      "role": "Required",
      "role_reason": "Material on Unique trials/teams, question/formulation correspondence and overlap among meta-analyses is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Unique trials/teams, question/formulation correspondence and overlap among meta-analyses must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial families, teams/support relationships and exact formulation/endpoint lists. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are PMID, DOI, PROSPERO and the stored summary distinguished?",
      "needed": "Original-report bibliography, registration wording, external-unread scope and stored JSON",
      "role": "Required",
      "role_reason": "Material on Original-report bibliography, registration wording, external-unread scope and stored JSON is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original-report bibliography, registration wording, external-unread scope and stored JSON must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Articles, registration and supplementary/original-trial material corresponding to the citation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "What are the nongovernmental support and product/author roles?",
      "needed": "Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles",
      "role": "Required",
      "role_reason": "Material on Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Cash/product support, affiliations/conflicts and meta-analysis/original-trial roles must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original meta-analysis/trial funding, conflict, author and product-support disclosures. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "How do original dates differ from the preparation timestamp?",
      "needed": "Original evidence date, correction date, meta-analysis publication/search and preparation timestamp",
      "role": "Required",
      "role_reason": "Material on Original evidence date, correction date, meta-analysis publication/search and preparation timestamp is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original evidence date, correction date, meta-analysis publication/search and preparation timestamp must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original search, receipt, publication and amendment-event records. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "How are generic English wording and the 1-field correction retained?",
      "needed": "Korean/English results, generic English evidence wording and before/after correction records",
      "role": "Required",
      "role_reason": "Material on Korean/English results, generic English evidence wording and before/after correction records is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Korean/English results, generic English evidence wording and before/after correction records must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Complete before/after English-correction originals and result translation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "What is the role of C54, historical cross-checking and axes here?",
      "needed": "Original grade, score, safety, axes, grade decision and empty values",
      "role": "Required",
      "role_reason": "Material on Original grade, score, safety, axes, grade decision and empty values is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Original grade, score, safety, axes, grade decision and empty values must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The original verdict and subsequent authorized correction events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "For which events and denominators were gastrointestinal complaints reported?",
      "needed": "Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration",
      "role": "Required",
      "role_reason": "Material on Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Event definitions/collection, arm-specific events/denominators, discontinuation/missingness and duration must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial adverse events/discontinuations, collection and arm-specific harm tables. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "What is known about formulation-specific safety beyond short-term use?",
      "needed": "Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions",
      "role": "Supplementary; required when extending safety scope",
      "role_reason": "Material on Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Longer-term/high-dose use, formulation/absorption, vulnerable groups and medicine interactions must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Longer follow-up, formulation/dose-specific harms and interaction material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Are harm timing, comparisons, alternative causes and independent cases available?",
      "needed": "Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families",
      "role": "Supplementary; required for harm causality/replication scope",
      "role_reason": "Material on Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Onset/recovery, discontinuation/re-exposure, comparator/concomitant medicines and case families must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Individual-event timing, concomitant/alternative explanations, between-group harms and unique-case material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Does enhanced bioavailability cause the weight effect?",
      "needed": "Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations",
      "role": "Supplementary; required for mechanism/formulation-superiority claims",
      "role_reason": "Material on Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Formulation-specific exposure/absorption, direct weight comparisons and alternative explanations must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Formulation-specific exposure/absorption and direct clinical outcomes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "How are the stored summary and unread materials connected?",
      "needed": "Material-specific acquisition/reading, original citation links and condition/evidence-change events",
      "role": "Required",
      "role_reason": "Material on Material-specific acquisition/reading, original citation links and condition/evidence-change events is needed to connect the relevant formulation, oral route, population, endpoint/units, duration, pooled/subgroup scope, denominator, overlap or harm scope.",
      "application_exception": "Pooled means, enhanced-formulation subgroups and direct formulation comparisons remain distinct, as do weight versus other anthropometric endpoints and reviews/trials/participants. Differences, percentage weight loss, independent-replication counts, optimum doses, guaranteed loss, obesity-treatment replacement and safety certification are not newly calculated or inferred.",
      "criterion": "Original records on Material-specific acquisition/reading, original citation links and condition/evidence-change events must link to the relevant report, trial, review, participant, formulation, endpoint, timepoint, units and denominator, distinguishing stored information from what remains unverified.",
      "basis": "Existing principles distinguish formulation, oral route, population, endpoint/units, duration, comparator, pooled/subgroup estimates, denominators, overlap, support and harms in the retained curcumin weight record.",
      "condition_origin": "These existing conditions are linked to the stored curcumin weight record. They explain material gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original material/corrections supplied or separately authorized. This records needed materials; no new research was executed."
    }
  ]
}