{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3024-main", "verdict_number": "3024", "title": "Single-ingredient oral vitamin C × Attenuation of post-exercise FEV1 decline", "view_version": "1.0", "view_created_date": "2026-10-23", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "The population comprises asthmatic participants with documented exercise-induced bronchoconstriction. Adults and mixed child/adolescent populations remain separate, with gaps in study-specific diagnosis, selection, baseline lung function and age composition retained. Findings are not automatically generalized to all people with asthma.", "intervention": "The intervention is a single-ingredient oral ascorbic acid supplement. Feedstock, manufacturing process, country and study-specific salt, tablet/capsule, excipients and actual content remain unverified. Foods, combinations and intravenous infusion are not automatically included.", "dose": "The original scope is single 500 mg or 2 g doses, or 1500 mg/day for 2 weeks. Study-specific timing, products, actual exposure, adherence and some dose mappings remain unverified. These are not converted into an identical dose, optimal dose, cumulative dose or individual dosing guidance.", "comparator": "The comparator is matched crossover placebo. Usual-diet observations are not a separate randomized arm, and crossover periods from one person are not additional participants. Placebo composition, maintained therapy, rescue medication, diet and pre-exercise rules remain unverified in detail.", "endpoint": "The physiological endpoint is maximum post-exercise FEV1 decline (% or L). Maximum values remain distinct from specific time points and units; prespecified primary hierarchy, detailed measurements and within-person estimation remain unverified. Symptoms, rescue medication, exacerbations and hospitalization are separate outcomes.", "duration": "Exposure is a single pre-challenge dose or 2-week crossover periods. The R01 citation’s 2 weeks per period and 1-week washout are not assigned to all other studies. Study-specific order, carryover/period effects and effects beyond the observation periods remain unverified.", "excluded_extensions": [ "The selected question concerns single-ingredient oral vitamin C and post-exercise lung function in documented exercise-induced bronchoconstriction and asthma. It is not extended to routine asthma control, prevention of exacerbations/hospitalization, inhaler replacement, training adaptation or muscle soreness.", "The existing C·54 points·Caution, stored assessment values, Korean and English descriptions and evidence date 2026-09-07 are retained. Historical wording about independent cross-checks does not establish current external reading, regrading or official assessment.", "The manuscript’s 3 crossover trials totaling 40 people is a stored description of synthesis size. It is not a new participant sum or certification of unique trials, participants or safety denominators. Original trials and reviews are not added together, and crossover periods are not additional people.", "The existing 6.5 percentage points is a recorded simple mean-difference calculation. It is not promoted to a within-person effect, adjusted estimate, paired 95% CI or clinical success rate, and no new difference or interval is calculated.", "Maximum percentage decline and 5-minute decline in litres, unspecified ± and explicitly recorded SE, and adults and mixed child/adolescent populations remain distinct. Units, ages and time points are not converted or pooled, and unverified dispersion is not assumed.", "The 9 responders remain distinct from outcomes for all 20 participants. No new response rate is calculated, and selected-responder follow-up is not converted into a whole-cohort effect or new independent randomized replication.", "The meta-analysis and general-asthma review differ in scope and are not new original trials. Original inclusion, extraction, within-person variance, shared-trial mapping, registrations, protocols and official risk/certainty assessments remain unverified.", "Existing caution about diarrhea, gastrointestinal discomfort, stone risk, kidney disease and iron overload with high oral doses is retained. Limited event records are not converted into no harms, long-term safety or confirmed contraindications; no new incidence rate, causality or individual dosing guidance is created." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which exercise-challenge question is addressed?", "needed": "Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma", "role": "Required", "role_reason": "Material on Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original diagnosis, exercise challenge, endpoint, measurement timing and placebo-comparison details are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The selected question concerns attenuation of post-exercise FEV1 decline, a physiological endpoint. Routine asthma control, prevention of clinical exacerbations and inhaler replacement remain separate.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original diagnosis, exercise challenge, endpoint, measurement timing and placebo-comparison details are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original diagnosis, exercise challenge, endpoint, measurement timing and placebo-comparison details are needed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are the single-ingredient product, salt and route known?", "needed": "Product, salt, excipients and manufacturing of oral ascorbic acid", "role": "Required", "role_reason": "Material on Product, salt, excipients and manufacturing of oral ascorbic acid is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Product, salt, excipients and manufacturing of oral ascorbic acid must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original product, manufacturing, salt, excipient and adherence records are needed; equivalence to other products remains unverified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The supplement contains single-ingredient ascorbic acid; study-specific salt, tablet/capsule and excipients remain unverified. Foods, combinations and intravenous infusion are not automatically included.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original product, manufacturing, salt, excipient and adherence records are needed; equivalence to other products remains unverified.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original product, manufacturing, salt, excipient and adherence records are needed; equivalence to other products remains unverified." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Are single doses and 2-week dosing kept separate?", "needed": "Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks", "role": "Required", "role_reason": "Material on Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Dosing timing, single/repeated administration, products, actual exposure and study mapping for 2 g are needed. Converted or recommended doses are not created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The original scope is single 500 mg or 2 g doses, or 1500 mg/day for 2 weeks. The R01 citation records 1500 mg/day for 2 weeks per period; R02 records 500 mg. Doses are not treated as identical across studies.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Dosing timing, single/repeated administration, products, actual exposure and study mapping for 2 g are needed. Converted or recommended doses are not created.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Dosing timing, single/repeated administration, products, actual exposure and study mapping for 2 g are needed. Converted or recommended doses are not created." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are single exposure, crossover periods and washout distinguished?", "needed": "Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout", "role": "Required", "role_reason": "Material on Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original periods, order, intervals, carryover, period effects and dosing/challenge timing are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The original scope is a single pre-challenge dose or 2-week crossover exposure. The R01 citation records 2 weeks per period and a 1-week washout. These schedules are not assigned to other studies.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original periods, order, intervals, carryover, period effects and dosing/challenge timing are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original periods, order, intervals, carryover, period effects and dosing/challenge timing are needed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Are adults and mixed child/adolescent populations distinguished?", "needed": "The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03", "role": "Required", "role_reason": "Material on The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03 is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03 must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original diagnosis, selection, age, baseline lung function and study-specific population tables are needed. Unrecorded ages are not inferred. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R01 records 8 adults and R02 records 12 asthmatic participants. R03 records 20 people aged 7–28, mean 13.8, mostly children and adolescents. These are not described as 40 adults.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original diagnosis, selection, age, baseline lung function and study-specific population tables are needed. Unrecorded ages are not inferred.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original diagnosis, selection, age, baseline lung function and study-specific population tables are needed. Unrecorded ages are not inferred." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "How were standardized exercise challenges and EIB established?", "needed": "Challenge intensity, environment, diagnostic criteria and FEV1 timing", "role": "Required", "role_reason": "Material on Challenge intensity, environment, diagnostic criteria and FEV1 timing is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Challenge intensity, environment, diagnostic criteria and FEV1 timing must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Challenge and measurement procedures, environment, baseline values, diagnosis, selection and assessor blinding are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The stored description states that participants with documented EIB underwent standardized exercise challenges. This remains distinct from testing real-world symptoms or training adaptation.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Challenge and measurement procedures, environment, baseline values, diagnosis, selection and assessor blinding are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Challenge and measurement procedures, environment, baseline values, diagnosis, selection and assessor blinding are needed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Are usual-diet observations distinguished from crossover placebo?", "needed": "Matched-placebo comparisons, usual-diet conditions and maintained treatment", "role": "Required", "role_reason": "Material on Matched-placebo comparisons, usual-diet conditions and maintained treatment is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Matched-placebo comparisons, usual-diet conditions and maintained treatment must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original condition order, usual-diet/placebo rules, comparable care and measurement schedules are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The comparison uses matched crossover placebo. The usual-diet −14.3±1.6% in R01 is not counted as a separate randomized arm or additional participants.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original condition order, usual-diet/placebo rules, comparable care and measurement schedules are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original condition order, usual-diet/placebo rules, comparable care and measurement schedules are needed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What were the period-specific rules for inhalers, diet and other treatment?", "needed": "Baseline asthma therapy, rescue medication, changes and pre-exercise rules", "role": "Required", "role_reason": "Material on Baseline asthma therapy, rescue medication, changes and pre-exercise rules is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Baseline asthma therapy, rescue medication, changes and pre-exercise rules must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Baseline medication, changes, adherence, rescue medication, shared diet/care and pre-exercise procedures are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The existing description that inhaler replacement exceeds the tested claims is retained. Actual medication maintenance, changes and rescue-medication rules are not detailed in the stored summary.", "condition_status": "Unverified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Baseline medication, changes, adherence, rescue medication, shared diet/care and pre-exercise procedures are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Baseline medication, changes, adherence, rescue medication, shared diet/care and pre-exercise procedures are needed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Are crossover order, periods and paired analyses known?", "needed": "Randomized order, concealment, washout, periods and within-person analysis", "role": "Required", "role_reason": "Material on Randomized order, concealment, washout, periods and within-person analysis is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Randomized order, concealment, washout, periods and within-person analysis must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original order, periods, carryover, crossover completion, within-person contrasts, variance, correlations and plans are needed. No new official risk assessment is created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R01 and R03 are recorded as double-blind placebo crossover studies; R02 as double-blind randomized crossover. Detailed order, adequacy of blinding and paired-analysis rules remain unverified.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original order, periods, carryover, crossover completion, within-person contrasts, variance, correlations and plans are needed. No new official risk assessment is created.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original order, periods, carryover, crossover completion, within-person contrasts, variance, correlations and plans are needed. No new official risk assessment is created." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "What are the 8 people and sequence-specific denominators in R01?", "needed": "Enrollment, crossover completion and sequence/endpoint analyses for 8 adults", "role": "Required", "role_reason": "Material on Enrollment, crossover completion and sequence/endpoint analyses for 8 adults is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Enrollment, crossover completion and sequence/endpoint analyses for 8 adults must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original sequence/period flow, denominators, missing data and discontinuations are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R01 records 8 people with asthma/EIB; sequence-specific analysis denominators and attrition details remain unverified. Two periods from one person are not added as different participants.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original sequence/period flow, denominators, missing data and discontinuations are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original sequence/period flow, denominators, missing data and discontinuations are needed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "What is the maximum FEV1 decline in R01?", "needed": "Original percentage declines, ± values and P for vitamin C, placebo and usual diet", "role": "Required", "role_reason": "Material on Original percentage declines, ± values and P for vitamin C, placebo and usual diet is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Original percentage declines, ± values and P for vitamin C, placebo and usual diet must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original timing, baseline values, within-person estimates, variance and condition/period mapping are needed. New differences or intervals are not calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Maximum FEV1 declines are recorded as C −6.4±2.4%, placebo −12.9±2.4% and usual diet −14.3±1.6%; P<.05. Conditions, units and the maximum-decline definition are retained.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original timing, baseline values, within-person estimates, variance and condition/period mapping are needed. New differences or intervals are not calculated.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original timing, baseline values, within-person estimates, variance and condition/period mapping are needed. New differences or intervals are not calculated." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Are the existing 6.5 percentage points and paired CI distinguished?", "needed": "Historical simple mean difference and original within-person estimate and 95% CI", "role": "Required", "role_reason": "Material on Historical simple mean difference and original within-person estimate and 95% CI is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Historical simple mean difference and original within-person estimate and 95% CI must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original within-person differences, variance, correlations, intervals and ± definitions are needed. The simple difference is not converted into an adjusted/paired effect or clinical success rate. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The existing record retains a simple mean difference of 6.5 percentage points, unverified paired 95% CI and unverified ± type. This is neither a new calculation nor a verified within-person effect.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original within-person differences, variance, correlations, intervals and ± definitions are needed. The simple difference is not converted into an adjusted/paired effect or clinical success rate.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original within-person differences, variance, correlations, intervals and ± definitions are needed. The simple difference is not converted into an adjusted/paired effect or clinical success rate." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are the 12 people and 500 mg in R02 retained separately?", "needed": "Sample, exposure and analysis denominators of the early trial", "role": "Required", "role_reason": "Material on Sample, exposure and analysis denominators of the early trial is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Sample, exposure and analysis denominators of the early trial must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original methods, allocation, completion, within-person analyses and dissertation/report mapping are needed. Unidentified samples or totals are not created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R02 records 12 asthmatic participants and the citation records 500 mg. The original note against confusion with the 1980 dissertation sample is retained.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original methods, allocation, completion, within-person analyses and dissertation/report mapping are needed. Unidentified samples or totals are not created.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original methods, allocation, completion, within-person analyses and dissertation/report mapping are needed. Unidentified samples or totals are not created." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What are the 5-minute FEV1 results in litres in R02?", "needed": "5-minute decline in litres, original mean±SE and within-person effect", "role": "Required", "role_reason": "Material on 5-minute decline in litres, original mean±SE and within-person effect is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on 5-minute decline in litres, original mean±SE and within-person effect must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original timing, contrasts, denominators, within-person variance and paired P/CI are needed. SE is not converted into SD and no new mean difference is calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R02 records 5-minute FEV1 declines of 0.24±0.06 L versus 0.44±0.14 L, mean±SE. Exact between-condition P and 95% CI remain unverified.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original timing, contrasts, denominators, within-person variance and paired P/CI are needed. SE is not converted into SD and no new mean difference is calculated.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original timing, contrasts, denominators, within-person variance and paired P/CI are needed. SE is not converted into SD and no new mean difference is calculated." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Are declines in litres and percentages of baseline kept separate?", "needed": "Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values", "role": "Required", "role_reason": "Material on Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original baseline values, units, timing, standardization and within-person analysis rules are needed. Converted or pooled values are not created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The 5-minute result in litres and maximum percentage decline differ in units and timing. They are not directly summed, as the existing description specifies.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original baseline values, units, timing, standardization and within-person analysis rules are needed. Converted or pooled values are not created.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original baseline values, units, timing, standardization and within-person analysis rules are needed. Converted or pooled values are not created." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are all 20 participants and the 9 responders in R03 distinguished?", "needed": "Effect and CI for all 20 participants, responder definition and denominator", "role": "Required", "role_reason": "Material on Effect and CI for all 20 participants, responder definition and denominator is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Effect and CI for all 20 participants, responder definition and denominator must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Whole-cohort outcomes, response definitions, selection, denominators and within-person effects/intervals are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R03 reports 9 responders. The exact paired effect and CI for all 20 remain unverified, so responder-only effects are not adopted. No new response rate is calculated.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Whole-cohort outcomes, response definitions, selection, denominators and within-person effects/intervals are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Whole-cohort outcomes, response definitions, selection, denominators and within-person effects/intervals are needed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Is selected-responder follow-up a randomized replication?", "needed": "Selection, follow-up extension, exposure, control and whole-cohort mapping", "role": "Required", "role_reason": "Material on Selection, follow-up extension, exposure, control and whole-cohort mapping is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Selection, follow-up extension, exposure, control and whole-cohort mapping must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original selection, extension, mapping to all 20 participants, denominators, comparison, timing and duration are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The existing description that selected-responder follow-up in R03 is not a randomized replication is retained. It is not promoted to a new independent trial or whole-cohort result.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original selection, extension, mapping to all 20 participants, denominators, comparison, timing and duration are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original selection, extension, mapping to all 20 participants, denominators, comparison, timing and duration are needed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are the 3 original trials distinguished from the meta-analysis?", "needed": "Crossover-trial inclusion and report mapping in the Hemilä review", "role": "Required", "role_reason": "Material on Crossover-trial inclusion and report mapping in the Hemilä review is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Crossover-trial inclusion and report mapping in the Hemilä review must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original inclusion/extraction tables, report/trial mapping, within-person denominators and overlap are needed. Final unique trial and participant counts remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The R04 citation records a signal from 3 crossover trials totaling 40 people. This is an existing description, not a newly certified sum. The review is not counted as another original trial.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original inclusion/extraction tables, report/trial mapping, within-person denominators and overlap are needed. Final unique trial and participant counts remain unverified.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original inclusion/extraction tables, report/trial mapping, within-person denominators and overlap are needed. Final unique trial and participant counts remain unverified." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Is the general-asthma review boundary retained?", "needed": "Directness between exercise-challenge lung function and routine asthma care", "role": "Supplementary", "role_reason": "Material on Directness between exercise-challenge lung function and routine asthma care is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Directness between exercise-challenge lung function and routine asthma care must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original review populations, interventions, outcomes and included-trial mapping are needed. No new guidelines or recommendations are sought or established. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R05 is a historical summary concerning insufficient evidence for routine asthma care. It is not counted as a direct EIB original trial or additional independent refutation.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original review populations, interventions, outcomes and included-trial mapping are needed. No new guidelines or recommendations are sought or established.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original review populations, interventions, outcomes and included-trial mapping are needed. No new guidelines or recommendations are sought or established." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What were the prespecified FEV1 hierarchy and symptom/marker choices?", "needed": "Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan", "role": "Required", "role_reason": "Material on Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Registration, protocols, analysis plans and all outcomes, time points and original result tables are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The trial records retain unverified prespecified hierarchies. The FEV1 emphasis and multiple symptom/inflammatory markers in R01 are not converted into a verified prespecified primary outcome.", "condition_status": "Unverified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Registration, protocols, analysis plans and all outcomes, time points and original result tables are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration, protocols, analysis plans and all outcomes, time points and original result tables are needed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What were the measurements, maximum-value selection and within-person estimation?", "needed": "Original measurement procedures, repeats, baseline, timing, variance and correlations", "role": "Required", "role_reason": "Material on Original measurement procedures, repeats, baseline, timing, variance and correlations is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Original measurement procedures, repeats, baseline, timing, variance and correlations must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original lung-function/challenge methods, assessors, repeated measurements, baseline values, plans and models are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The endpoint description is maximum post-exercise FEV1 decline (% or L). Detailed measurement, maximum-value selection and within-person estimation methods are absent from the stored summary.", "condition_status": "Unverified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original lung-function/challenge methods, assessors, repeated measurements, baseline values, plans and models are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original lung-function/challenge methods, assessors, repeated measurements, baseline values, plans and models are needed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "What were the missing data, incomplete crossover and treatment changes?", "needed": "Sequence/period attrition, missing outcomes and analysis exclusions", "role": "Required", "role_reason": "Material on Sequence/period attrition, missing outcomes and analysis exclusions is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Sequence/period attrition, missing outcomes and analysis exclusions must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Study-specific flow, discontinuations, missing-data handling, analysis sets, sensitivity analyses and period-specific treatment changes are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Sequence-specific denominators and attrition in R01 are unverified, and detailed flow for other trials is not stored. Unread external material is not treated as no missing data.", "condition_status": "Unverified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Study-specific flow, discontinuations, missing-data handling, analysis sets, sensitivity analyses and period-specific treatment changes are needed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Study-specific flow, discontinuations, missing-data handling, analysis sets, sensitivity analyses and period-specific treatment changes are needed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are symptom improvement and prevention of exacerbations/hospitalization separate?", "needed": "Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization", "role": "Supplementary", "role_reason": "Material on Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Direct evidence for each patient outcome, prespecified definition, timing, denominator and comparator is needed. Lung-function values are not copied into clinical outcomes. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Physiological endpoints and real-world symptoms, rescue medication and clinical exacerbations are different questions. An improved symptom score also does not establish prevention of exacerbations.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Direct evidence for each patient outcome, prespecified definition, timing, denominator and comparator is needed. Lung-function values are not copied into clinical outcomes.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct evidence for each patient outcome, prespecified definition, timing, denominator and comparator is needed. Lung-function values are not copied into clinical outcomes." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are inhaler replacement, general asthma and training effects kept outside scope?", "needed": "Boundaries between the selected exercise-challenge question and other treatments/indications", "role": "Supplementary", "role_reason": "Material on Boundaries between the selected exercise-challenge question and other treatments/indications is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Boundaries between the selected exercise-challenge question and other treatments/indications must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Direct evidence for treatment replacement, routine asthma control and training adaptation is needed. Content or grades from other pages are not imported. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Claims of preventing asthma with a pre-exercise pill or replacing inhalers exceed the existing scope. General asthma, breathing techniques and muscle soreness are also separate questions.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Direct evidence for treatment replacement, routine asthma control and training adaptation is needed. Content or grades from other pages are not imported.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct evidence for treatment replacement, routine asthma control and training adaptation is needed. Content or grades from other pages are not imported." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are publication-bias and independent-confirmation limits retained?", "needed": "Unpublished small studies, registration, independent teams and report families", "role": "Required", "role_reason": "Material on Unpublished small studies, registration, independent teams and report families is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Unpublished small studies, registration, independent teams and report families must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Registration, search/inclusion tables, unpublished results, teams, products and report mapping are needed. No new replication count or official certainty grade is calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The similar physiological direction and limitations from small studies/publication bias are both retained. The original independence assessment is preserved without certifying new independent replication.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Registration, search/inclusion tables, unpublished results, teams, products and report mapping are needed. No new replication count or official certainty grade is calculated.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration, search/inclusion tables, unpublished results, teams, products and report mapping are needed. No new replication count or official certainty grade is calculated." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are the four company-involvement pathways known?", "needed": "Funding, manufacturing/product support, employee authors and conflicts of interest", "role": "Required", "role_reason": "Material on Funding, manufacturing/product support, employee authors and conflicts of interest is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Funding, manufacturing/product support, employee authors and conflicts of interest must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original funding, products, affiliations and conflict disclosures are needed. Historical independence descriptions remain distinct from the current verification scope. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "R01 has only a non-US research-support indexing description; actual funding and manufacturer remain unverified. R02 and R03 are also unverified. Indexing is not converted into noncommercial status or no company involvement.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original funding, products, affiliations and conflict disclosures are needed. Historical independence descriptions remain distinct from the current verification scope.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original funding, products, affiliations and conflict disclosures are needed. Historical independence descriptions remain distinct from the current verification scope." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Are harm collection, events and discontinuations known?", "needed": "Diarrhea, gastrointestinal discomfort, collection, severity and original events", "role": "Supplementary", "role_reason": "Material on Diarrhea, gastrointestinal discomfort, collection, severity and original events is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Diarrhea, gastrointestinal discomfort, collection, severity and original events must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original harm methods, events, discontinuations, omissions, comparators and periods are needed. Unread material is not treated as no harms. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Existing caution about gastrointestinal effects of high oral vitamin C doses and limited trial-specific event counts is retained. Actual harm collection and events are not detailed.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Original harm methods, events, discontinuations, omissions, comparators and periods are needed. Unread material is not treated as no harms.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original harm methods, events, discontinuations, omissions, comparators and periods are needed. Unread material is not treated as no harms." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "What were the safety denominators, single/2-week exposure and comparators?", "needed": "Safety sets, actual dosing, events and exposure by crossover period", "role": "Supplementary", "role_reason": "Material on Safety sets, actual dosing, events and exposure by crossover period is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Safety sets, actual dosing, events and exposure by crossover period must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Period-specific safety denominators, exposure, discontinuations, events, comparisons and shared-participant mapping are needed. Incidence rates are not calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The original 8, 12 and 20 people and the description of 40 overall do not establish safety denominators. Periods from the same person are not added as participants.", "condition_status": "Unverified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Period-specific safety denominators, exposure, discontinuations, events, comparisons and shared-participant mapping are needed. Incidence rates are not calculated.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Period-specific safety denominators, exposure, discontinuations, events, comparisons and shared-participant mapping are needed. Incidence rates are not calculated." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "What is known about vulnerable groups, concomitant drugs and long-term/rare harms?", "needed": "Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms", "role": "Supplementary", "role_reason": "Material on Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Vulnerable groups, concomitant use, timing, independent reports, longer exposure, denominators, controls and event courses are needed. No new harm search or assessment is performed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Existing caution about stone risk, kidney disease and iron overload, short exposure and mixed ages is retained. Long-term safety and drug-specific event causality are not certified.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Vulnerable groups, concomitant use, timing, independent reports, longer exposure, denominators, controls and event courses are needed. No new harm search or assessment is performed.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Vulnerable groups, concomitant use, timing, independent reports, longer exposure, denominators, controls and event courses are needed. No new harm search or assessment is performed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are historical checking and current unread external materials distinguished?", "needed": "Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans", "role": "Required", "role_reason": "Material on Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Actual external acquisition, reading and review remain outstanding. Historical checking, bibliography links or full-text identifiers do not establish current reading or completed review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Existing wording about abstract checking and independent cross-checks is historical. Stored summaries were read here; external abstracts, full text, registrations, protocols and analysis plans were not.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "Actual external acquisition, reading and review remain outstanding. Historical checking, bibliography links or full-text identifiers do not establish current reading or completed review.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual external acquisition, reading and review remain outstanding. Historical checking, bibliography links or full-text identifiers do not establish current reading or completed review." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are original Korean/English descriptions, empty corrections and existing calculation wording retained?", "needed": "Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record", "role": "Supplementary", "role_reason": "Material on Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: New evidence, corrections and verdict changes require preservation of originals and separate event records. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "Existing Korean/English descriptions, empty correction/detailed-claim records and existing calculation wording are preserved. No new correction, calculation or completed external clinical review is created.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "New evidence, corrections and verdict changes require preservation of originals and separate event records.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "New evidence, corrections and verdict changes require preservation of originals and separate event records." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "Are original C54, assessment values and evidence date distinguished from production?", "needed": "C54, Caution, existing assessment values and evidence date", "role": "Required", "role_reason": "Material on C54, Caution, existing assessment values and evidence date is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.", "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.", "criterion": "Original records on C54, Caution, existing assessment values and evidence date must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.", "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: New evidence, revised criteria and verdict changes are separate events. The existing date is not used as a current search or external-reading date. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Existing Korean and English stored summaries, crossover-trial records and review bibliography read; external abstracts, full text, registrations, protocols and analysis plans unread", "observation": "The existing C·54 points·Caution, assessment values and evidence date 2026-09-07 are retained. The 40-person total and independence strength are original descriptions, not a new certification, sum or grade.", "condition_status": "Partly verified", "status_reason": "Stored information is linked to gaps in detailed material. External verification and clinical content review remain incomplete; fulfilled conditions, effects, safety, prespecification and independence are not certified.", "missingness": "New evidence, revised criteria and verdict changes are separate events. The existing date is not used as a current search or external-reading date.", "uncertainty": "Gaps in original diagnosis, challenge, units, timing, within-person variance, denominators, plans, inclusion/extraction, support and harms remain. Small physiological signals are not converted into established clinical prevention, a precise null effect, equivalence or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "New evidence, revised criteria and verdict changes are separate events. The existing date is not used as a current search or external-reading date." } ], "reports": [ { "report_id": "R01", "title": "Tecklenburg et al. 2007 · Asthma/EIB crossover trial", "url": "https://pubmed.ncbi.nlm.nih.gov/17412579/", "report_type": "Double-blind placebo crossover trial", "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The 3 crossover original-trial reports remain distinct from 2 meta-analysis/general-asthma review citations; units, ages, periods, responders, paired denominators/CI and shared-trial mapping remain unverified", "independent_replication": "Reports remain distinct from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "Maximum FEV1 decline: C −6.4±2.4%, placebo −12.9±2.4%, usual diet −14.3±1.6%; P<.05. The simple mean difference of 6.5 percentage points is an existing record; paired 95% CI and ± type remain unverified.", "result_level": "There are 8 adults with asthma/EIB. Sequence-specific analysis denominators, attrition and within-person analysis details remain unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:46:26.948752+09:00", "qualification": "PMID 17412579 · DOI 10.1016/j.rmed.2007.02.014. Historical abstract checking remains distinct from current stored-summary reading. External full text, registration and plans are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 17412579 · DOI 10.1016/j.rmed.2007.02.014. Historical abstract checking remains distinct from current stored-summary reading. External full text, registration and plans are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 17412579 · DOI 10.1016/j.rmed.2007.02.014. Historical abstract checking remains distinct from current stored-summary reading. External full text, registration and plans are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 17412579 · DOI 10.1016/j.rmed.2007.02.014. Historical abstract checking remains distinct from current stored-summary reading. External full text, registration and plans are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 17412579 · DOI 10.1016/j.rmed.2007.02.014. Historical abstract checking remains distinct from current stored-summary reading. External full text, registration and plans are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/17412579/" } ] }, { "report_id": "R02", "title": "Schachter·Schlesinger 1982 · Early crossover trial", "url": "https://pubmed.ncbi.nlm.nih.gov/7114587/", "report_type": "Double-blind randomized crossover trial", "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The 3 crossover original-trial reports remain distinct from 2 meta-analysis/general-asthma review citations; units, ages, periods, responders, paired denominators/CI and shared-trial mapping remain unverified", "independent_replication": "Reports remain distinct from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "5-minute FEV1 declines are 0.24±0.06 L versus 0.44±0.14 L, mean±SE. Exact between-condition P and 95% CI remain unverified; values are not directly added to percentage declines.", "result_level": "There are 12 asthmatic participants. Original sequence, completion and within-person denominators remain unverified; confusion with the dissertation sample is avoided.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:46:26.948752+09:00", "qualification": "PMID 7114587. Historical abstract checking remains historical. Sample mapping to the dissertation, registration and plans were not newly verified here. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 7114587. Historical abstract checking remains historical. Sample mapping to the dissertation, registration and plans were not newly verified here. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 7114587. Historical abstract checking remains historical. Sample mapping to the dissertation, registration and plans were not newly verified here. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 7114587. Historical abstract checking remains historical. Sample mapping to the dissertation, registration and plans were not newly verified here. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 7114587. Historical abstract checking remains historical. Sample mapping to the dissertation, registration and plans were not newly verified here. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/7114587/" } ] }, { "report_id": "R03", "title": "Cohen et al. 1997 · Mixed-age crossover trial", "url": "https://pubmed.ncbi.nlm.nih.gov/9111435/", "report_type": "Double-blind placebo crossover trial", "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The 3 crossover original-trial reports remain distinct from 2 meta-analysis/general-asthma review citations; units, ages, periods, responders, paired denominators/CI and shared-trial mapping remain unverified", "independent_replication": "Reports remain distinct from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "There are 9 reported responders. The exact paired effect and 95% CI for all 20 remain unverified, so responder-only effects are not adopted.", "result_level": "There are 20 people aged 7–28, mean 13.8, mostly children and adolescents. Selected-responder follow-up is not a randomized replication.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:46:26.948752+09:00", "qualification": "PMID 9111435 · DOI 10.1001/archpedi.1997.02170410041005. Historical abstract checking is not current external reading. The whole cohort remains distinct from selected-responder observations. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 9111435 · DOI 10.1001/archpedi.1997.02170410041005. Historical abstract checking is not current external reading. The whole cohort remains distinct from selected-responder observations. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 9111435 · DOI 10.1001/archpedi.1997.02170410041005. Historical abstract checking is not current external reading. The whole cohort remains distinct from selected-responder observations. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 9111435 · DOI 10.1001/archpedi.1997.02170410041005. Historical abstract checking is not current external reading. The whole cohort remains distinct from selected-responder observations. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 9111435 · DOI 10.1001/archpedi.1997.02170410041005. Historical abstract checking is not current external reading. The whole cohort remains distinct from selected-responder observations. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/9111435/" } ] }, { "report_id": "R04", "title": "Hemilä 2013 · Exercise-induced bronchoconstriction meta-analysis", "url": "https://pubmed.ncbi.nlm.nih.gov/23794586/", "report_type": "Meta-analysis citation/summary; not a new original trial", "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The 3 crossover original-trial reports remain distinct from 2 meta-analysis/general-asthma review citations; units, ages, periods, responders, paired denominators/CI and shared-trial mapping remain unverified", "independent_replication": "Reports remain distinct from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "The existing description concerns an FEV1 signal from 3 crossover trials totaling 40 people. It is not a new sum or certification of independent replication.", "result_level": "Original inclusion, extraction, within-person analyses and shared-trial mapping remain unverified. Independent people or trials are not counted in addition to the original trials.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:46:26.948752+09:00", "qualification": "PMID 23794586 · PMC3686214. Historical independent-cross-check wording and a full-text identifier do not establish current full-text reading or official assessment. Original inclusion, extraction and analyses are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 23794586 · PMC3686214. Historical independent-cross-check wording and a full-text identifier do not establish current full-text reading or official assessment. Original inclusion, extraction and analyses are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 23794586 · PMC3686214. Historical independent-cross-check wording and a full-text identifier do not establish current full-text reading or official assessment. Original inclusion, extraction and analyses are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 23794586 · PMC3686214. Historical independent-cross-check wording and a full-text identifier do not establish current full-text reading or official assessment. Original inclusion, extraction and analyses are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 23794586 · PMC3686214. Historical independent-cross-check wording and a full-text identifier do not establish current full-text reading or official assessment. Original inclusion, extraction and analyses are currently unread. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/23794586/" } ] }, { "report_id": "R05", "title": "Cochrane 2013 · General-asthma review", "url": "https://pubmed.ncbi.nlm.nih.gov/24154977/", "report_type": "General-asthma systematic-review citation/boundary summary", "existence": "The information is recorded in stored crossover-trial summaries, meta-analysis and general-asthma review citations. Current reading of external abstracts, full text, registrations and plans remains separately unverified.", "acquired_read": "Stored existing review summary read; external material unread", "study_family": "The 3 crossover original-trial reports remain distinct from 2 meta-analysis/general-asthma review citations; units, ages, periods, responders, paired denominators/CI and shared-trial mapping remain unverified", "independent_replication": "Reports remain distinct from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "This is a historical boundary description concerning insufficient evidence for routine asthma care. It is not a direct original exercise-challenge trial or additional independent refutation.", "result_level": "Original populations, interventions, outcomes and included-trial mapping remain unverified. No new recommendation, guideline or current reading of the review is established.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:46:26.948752+09:00", "qualification": "PMID 24154977. The scope of routine asthma care remains distinct from the selected exercise-challenge question. Historical independent checking is not promoted to current original-review reading or a new clinical recommendation. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 24154977. The scope of routine asthma care remains distinct from the selected exercise-challenge question. Historical independent checking is not promoted to current original-review reading or a new clinical recommendation. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 24154977. The scope of routine asthma care remains distinct from the selected exercise-challenge question. Historical independent checking is not promoted to current original-review reading or a new clinical recommendation. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 24154977. The scope of routine asthma care remains distinct from the selected exercise-challenge question. Historical independent checking is not promoted to current original-review reading or a new clinical recommendation. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID 24154977. The scope of routine asthma care remains distinct from the selected exercise-challenge question. Historical independent checking is not promoted to current original-review reading or a new clinical recommendation. Original material-specific dates and absent dates are retained without conversion into current external-reading dates." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/24154977/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "The 3 stored evidence entries and 5 citations link to 3 crossover original-trial reports and 2 meta-analysis/general-asthma review records. Inclusion, extraction, shared-participant mapping and final unique trial/participant counts remain unverified; report counts are not converted into independent replications or new totals." }, "history": [ { "date": "2026-10-23", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "The public view and materials were prepared from the existing 32 items. No new clinical search, verification-state change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-23" }