{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Single-ingredient oral vitamin C × Attenuation of post-exercise FEV1 decline",
  "language": "en",
  "translation_date": "2026-10-23",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which exercise-challenge question is addressed?",
      "needed": "Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma",
      "role": "Required",
      "role_reason": "Material on Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral vitamin C and maximum post-exercise FEV1 decline in documented EIB and asthma must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original diagnosis, exercise challenge, endpoint, measurement timing and placebo-comparison details are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are the single-ingredient product, salt and route known?",
      "needed": "Product, salt, excipients and manufacturing of oral ascorbic acid",
      "role": "Required",
      "role_reason": "Material on Product, salt, excipients and manufacturing of oral ascorbic acid is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Product, salt, excipients and manufacturing of oral ascorbic acid must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original product, manufacturing, salt, excipient and adherence records are needed; equivalence to other products remains unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Are single doses and 2-week dosing kept separate?",
      "needed": "Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks",
      "role": "Required",
      "role_reason": "Material on Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Study-specific mapping of single 500 mg or 2 g doses and 1500 mg/day for 2 weeks must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Dosing timing, single/repeated administration, products, actual exposure and study mapping for 2 g are needed. Converted or recommended doses are not created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are single exposure, crossover periods and washout distinguished?",
      "needed": "Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout",
      "role": "Required",
      "role_reason": "Material on Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Report-specific schedules for pre-exercise dosing, 2-week periods and 1-week washout must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original periods, order, intervals, carryover, period effects and dosing/challenge timing are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are adults and mixed child/adolescent populations distinguished?",
      "needed": "The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03",
      "role": "Required",
      "role_reason": "Material on The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03 is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on The 8 adults in R01, 12 asthmatic participants in R02 and ages 7–28 in R03 must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original diagnosis, selection, age, baseline lung function and study-specific population tables are needed. Unrecorded ages are not inferred. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "How were standardized exercise challenges and EIB established?",
      "needed": "Challenge intensity, environment, diagnostic criteria and FEV1 timing",
      "role": "Required",
      "role_reason": "Material on Challenge intensity, environment, diagnostic criteria and FEV1 timing is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Challenge intensity, environment, diagnostic criteria and FEV1 timing must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Challenge and measurement procedures, environment, baseline values, diagnosis, selection and assessor blinding are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are usual-diet observations distinguished from crossover placebo?",
      "needed": "Matched-placebo comparisons, usual-diet conditions and maintained treatment",
      "role": "Required",
      "role_reason": "Material on Matched-placebo comparisons, usual-diet conditions and maintained treatment is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Matched-placebo comparisons, usual-diet conditions and maintained treatment must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original condition order, usual-diet/placebo rules, comparable care and measurement schedules are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What were the period-specific rules for inhalers, diet and other treatment?",
      "needed": "Baseline asthma therapy, rescue medication, changes and pre-exercise rules",
      "role": "Required",
      "role_reason": "Material on Baseline asthma therapy, rescue medication, changes and pre-exercise rules is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Baseline asthma therapy, rescue medication, changes and pre-exercise rules must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Baseline medication, changes, adherence, rescue medication, shared diet/care and pre-exercise procedures are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are crossover order, periods and paired analyses known?",
      "needed": "Randomized order, concealment, washout, periods and within-person analysis",
      "role": "Required",
      "role_reason": "Material on Randomized order, concealment, washout, periods and within-person analysis is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Randomized order, concealment, washout, periods and within-person analysis must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original order, periods, carryover, crossover completion, within-person contrasts, variance, correlations and plans are needed. No new official risk assessment is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What are the 8 people and sequence-specific denominators in R01?",
      "needed": "Enrollment, crossover completion and sequence/endpoint analyses for 8 adults",
      "role": "Required",
      "role_reason": "Material on Enrollment, crossover completion and sequence/endpoint analyses for 8 adults is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Enrollment, crossover completion and sequence/endpoint analyses for 8 adults must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original sequence/period flow, denominators, missing data and discontinuations are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What is the maximum FEV1 decline in R01?",
      "needed": "Original percentage declines, ± values and P for vitamin C, placebo and usual diet",
      "role": "Required",
      "role_reason": "Material on Original percentage declines, ± values and P for vitamin C, placebo and usual diet is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original percentage declines, ± values and P for vitamin C, placebo and usual diet must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original timing, baseline values, within-person estimates, variance and condition/period mapping are needed. New differences or intervals are not calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are the existing 6.5 percentage points and paired CI distinguished?",
      "needed": "Historical simple mean difference and original within-person estimate and 95% CI",
      "role": "Required",
      "role_reason": "Material on Historical simple mean difference and original within-person estimate and 95% CI is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Historical simple mean difference and original within-person estimate and 95% CI must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original within-person differences, variance, correlations, intervals and ± definitions are needed. The simple difference is not converted into an adjusted/paired effect or clinical success rate. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are the 12 people and 500 mg in R02 retained separately?",
      "needed": "Sample, exposure and analysis denominators of the early trial",
      "role": "Required",
      "role_reason": "Material on Sample, exposure and analysis denominators of the early trial is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Sample, exposure and analysis denominators of the early trial must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original methods, allocation, completion, within-person analyses and dissertation/report mapping are needed. Unidentified samples or totals are not created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What are the 5-minute FEV1 results in litres in R02?",
      "needed": "5-minute decline in litres, original mean±SE and within-person effect",
      "role": "Required",
      "role_reason": "Material on 5-minute decline in litres, original mean±SE and within-person effect is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on 5-minute decline in litres, original mean±SE and within-person effect must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original timing, contrasts, denominators, within-person variance and paired P/CI are needed. SE is not converted into SD and no new mean difference is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are declines in litres and percentages of baseline kept separate?",
      "needed": "Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values",
      "role": "Required",
      "role_reason": "Material on Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinct estimands for absolute litres, percentage decline, maximum and 5-minute values must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original baseline values, units, timing, standardization and within-person analysis rules are needed. Converted or pooled values are not created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are all 20 participants and the 9 responders in R03 distinguished?",
      "needed": "Effect and CI for all 20 participants, responder definition and denominator",
      "role": "Required",
      "role_reason": "Material on Effect and CI for all 20 participants, responder definition and denominator is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Effect and CI for all 20 participants, responder definition and denominator must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Whole-cohort outcomes, response definitions, selection, denominators and within-person effects/intervals are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Is selected-responder follow-up a randomized replication?",
      "needed": "Selection, follow-up extension, exposure, control and whole-cohort mapping",
      "role": "Required",
      "role_reason": "Material on Selection, follow-up extension, exposure, control and whole-cohort mapping is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Selection, follow-up extension, exposure, control and whole-cohort mapping must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original selection, extension, mapping to all 20 participants, denominators, comparison, timing and duration are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Are the 3 original trials distinguished from the meta-analysis?",
      "needed": "Crossover-trial inclusion and report mapping in the Hemilä review",
      "role": "Required",
      "role_reason": "Material on Crossover-trial inclusion and report mapping in the Hemilä review is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Crossover-trial inclusion and report mapping in the Hemilä review must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original inclusion/extraction tables, report/trial mapping, within-person denominators and overlap are needed. Final unique trial and participant counts remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Is the general-asthma review boundary retained?",
      "needed": "Directness between exercise-challenge lung function and routine asthma care",
      "role": "Supplementary",
      "role_reason": "Material on Directness between exercise-challenge lung function and routine asthma care is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Directness between exercise-challenge lung function and routine asthma care must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original review populations, interventions, outcomes and included-trial mapping are needed. No new guidelines or recommendations are sought or established. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What were the prespecified FEV1 hierarchy and symptom/marker choices?",
      "needed": "Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan",
      "role": "Required",
      "role_reason": "Material on Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Primary lung-function outcome, timing, symptoms, inflammatory markers and multiplicity plan must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Registration, protocols, analysis plans and all outcomes, time points and original result tables are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What were the measurements, maximum-value selection and within-person estimation?",
      "needed": "Original measurement procedures, repeats, baseline, timing, variance and correlations",
      "role": "Required",
      "role_reason": "Material on Original measurement procedures, repeats, baseline, timing, variance and correlations is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original measurement procedures, repeats, baseline, timing, variance and correlations must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original lung-function/challenge methods, assessors, repeated measurements, baseline values, plans and models are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What were the missing data, incomplete crossover and treatment changes?",
      "needed": "Sequence/period attrition, missing outcomes and analysis exclusions",
      "role": "Required",
      "role_reason": "Material on Sequence/period attrition, missing outcomes and analysis exclusions is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Sequence/period attrition, missing outcomes and analysis exclusions must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific flow, discontinuations, missing-data handling, analysis sets, sensitivity analyses and period-specific treatment changes are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are symptom improvement and prevention of exacerbations/hospitalization separate?",
      "needed": "Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization",
      "role": "Supplementary",
      "role_reason": "Material on Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Direct outcomes for real-world symptoms, rescue medication, exacerbations and hospitalization must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct evidence for each patient outcome, prespecified definition, timing, denominator and comparator is needed. Lung-function values are not copied into clinical outcomes. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are inhaler replacement, general asthma and training effects kept outside scope?",
      "needed": "Boundaries between the selected exercise-challenge question and other treatments/indications",
      "role": "Supplementary",
      "role_reason": "Material on Boundaries between the selected exercise-challenge question and other treatments/indications is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Boundaries between the selected exercise-challenge question and other treatments/indications must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct evidence for treatment replacement, routine asthma control and training adaptation is needed. Content or grades from other pages are not imported. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are publication-bias and independent-confirmation limits retained?",
      "needed": "Unpublished small studies, registration, independent teams and report families",
      "role": "Required",
      "role_reason": "Material on Unpublished small studies, registration, independent teams and report families is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Unpublished small studies, registration, independent teams and report families must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Registration, search/inclusion tables, unpublished results, teams, products and report mapping are needed. No new replication count or official certainty grade is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are the four company-involvement pathways known?",
      "needed": "Funding, manufacturing/product support, employee authors and conflicts of interest",
      "role": "Required",
      "role_reason": "Material on Funding, manufacturing/product support, employee authors and conflicts of interest is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Funding, manufacturing/product support, employee authors and conflicts of interest must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original funding, products, affiliations and conflict disclosures are needed. Historical independence descriptions remain distinct from the current verification scope. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Are harm collection, events and discontinuations known?",
      "needed": "Diarrhea, gastrointestinal discomfort, collection, severity and original events",
      "role": "Supplementary",
      "role_reason": "Material on Diarrhea, gastrointestinal discomfort, collection, severity and original events is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Diarrhea, gastrointestinal discomfort, collection, severity and original events must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original harm methods, events, discontinuations, omissions, comparators and periods are needed. Unread material is not treated as no harms. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What were the safety denominators, single/2-week exposure and comparators?",
      "needed": "Safety sets, actual dosing, events and exposure by crossover period",
      "role": "Supplementary",
      "role_reason": "Material on Safety sets, actual dosing, events and exposure by crossover period is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Safety sets, actual dosing, events and exposure by crossover period must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Period-specific safety denominators, exposure, discontinuations, events, comparisons and shared-participant mapping are needed. Incidence rates are not calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is known about vulnerable groups, concomitant drugs and long-term/rare harms?",
      "needed": "Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms",
      "role": "Supplementary",
      "role_reason": "Material on Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Kidney disease, stones, iron overload, age, concomitant use, alternative causes and independent harms must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Vulnerable groups, concomitant use, timing, independent reports, longer exposure, denominators, controls and event courses are needed. No new harm search or assessment is performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Are historical checking and current unread external materials distinguished?",
      "needed": "Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans",
      "role": "Required",
      "role_reason": "Material on Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Historical access descriptions, stored summaries, external abstracts, full text, registrations and plans must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Actual external acquisition, reading and review remain outstanding. Historical checking, bibliography links or full-text identifiers do not establish current reading or completed review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Are original Korean/English descriptions, empty corrections and existing calculation wording retained?",
      "needed": "Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record",
      "role": "Supplementary",
      "role_reason": "Material on Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Complete originals, empty corrections/detailed claims and the existing 6.5-percentage-point record must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: New evidence, corrections and verdict changes require preservation of originals and separate event records. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Are original C54, assessment values and evidence date distinguished from production?",
      "needed": "C54, Caution, existing assessment values and evidence date",
      "role": "Required",
      "role_reason": "Material on C54, Caution, existing assessment values and evidence date is needed to connect the selected exercise-challenge question to its oral formulation, population, crossover comparison, units, timing, within-person analysis, denominators, precision and harms.",
      "application_exception": "Physiological lung-function signals remain separate from routine asthma control, exacerbations, hospitalization and inhaler replacement. Crossover periods are not additional people, and selected-responder extensions are not independent trials. Units, ages and time points are not mixed; no new effects, intervals, rates, participant totals, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on C54, Caution, existing assessment values and evidence date must link to the same question, route, population, comparison, endpoint, units, timing and within-person analysis, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, crossover design, within-person analyses, units, timing, reports and trials, and harms.",
      "condition_origin": "These existing conditions concern single-ingredient oral vitamin C and post-exercise lung-function decline in documented exercise-induced bronchoconstriction and asthma. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: New evidence, revised criteria and verdict changes are separate events. The existing date is not used as a current search or external-reading date. This records needed materials; no new research was executed."
    }
  ]
}