{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Single-ingredient oral vitamin C supplementation × Prevention of incident pneumonia",
  "language": "en",
  "translation_date": "2026-10-23",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which vitamin C and pneumonia-prevention question is selected?",
      "needed": "Single-ingredient oral supplementation, high-stress/low-intake population, new pneumonia, comparison and duration",
      "role": "Required",
      "role_reason": "Material on Single-ingredient oral supplementation, high-stress/low-intake population, new pneumonia, comparison and duration is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Single-ingredient oral supplementation, high-stress/low-intake population, new pneumonia, comparison and duration must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Review of the independent question boundary remains incomplete, and separate detailed-claim records are empty. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What is known about the purified nutrient’s feedstock and manufacture?",
      "needed": "Feedstock, manufacturing process, country, batch and nonapplicability of plant part",
      "role": "Required",
      "role_reason": "Material on Feedstock, manufacturing process, country, batch and nonapplicability of plant part is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Feedstock, manufacturing process, country, batch and nonapplicability of plant part must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact feedstock, manufacture, country and batch information is needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Which tablet/capsule, salt and excipients were used?",
      "needed": "Single-ingredient ascorbic acid and study-specific formulation, salt, excipients and content",
      "role": "Required",
      "role_reason": "Material on Single-ingredient ascorbic acid and study-specific formulation, salt, excipients and content is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Single-ingredient ascorbic acid and study-specific formulation, salt, excipients and content must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Actual products, content, formulations, salts, excipients and quality records are needed by study. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Do foods, combinations and intravenous dosing address the same question?",
      "needed": "Separation of single-ingredient oral supplements from foods, combinations, intravenous dosing and other exposures",
      "role": "Required",
      "role_reason": "Material on Separation of single-ingredient oral supplements from foods, combinations, intravenous dosing and other exposures is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Separation of single-ingredient oral supplements from foods, combinations, intravenous dosing and other exposures must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct effects of other routes, foods and combinations for the same prevention question remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What study-specific doses does 1 to 2 g/day represent?",
      "needed": "Study-specific actual doses, frequency, adherence and baseline intake",
      "role": "Required",
      "role_reason": "Material on Study-specific actual doses, frequency, adherence and baseline intake is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Study-specific actual doses, frequency, adherence and baseline intake must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact doses, frequency, duration mapping, actual adherence and baseline dietary intake are needed by study. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "How do 8 to 14 weeks of dosing map to pneumonia follow-up?",
      "needed": "Study-specific dosing, diagnosis, follow-up, visits, completion and discontinuation timing",
      "role": "Required",
      "role_reason": "Material on Study-specific dosing, diagnosis, follow-up, visits, completion and discontinuation timing is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Study-specific dosing, diagnosis, follow-up, visits, completion and discontinuation timing must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact study-specific dosing/follow-up periods, visit/diagnosis timing and persistence beyond that period remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Who were the military-training or low-intake populations?",
      "needed": "Training, physical stress, low intake, eligibility and baseline status",
      "role": "Required",
      "role_reason": "Material on Training, physical stress, low intake, eligibility and baseline status is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Training, physical stress, low intake, eligibility and baseline status must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific age, sex, exposure, selection, baseline infection/nutrition and relevance to contemporary general populations remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How were low intake and vitamin C status measured?",
      "needed": "Dietary intake, blood status, deficiency criteria, other supplements and baseline risk",
      "role": "Required",
      "role_reason": "Material on Dietary intake, blood status, deficiency criteria, other supplements and baseline risk is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Dietary intake, blood status, deficiency criteria, other supplements and baseline risk must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific intake, blood status, deficiency criteria, other nutritional supplements and baseline risk are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What shared care did placebo or no-supplement groups receive?",
      "needed": "Placebo, no supplementation, shared care, diet, nutrition and infection management",
      "role": "Required",
      "role_reason": "Material on Placebo, no supplementation, shared care, diet, nutrition and infection management is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Placebo, no supplementation, shared care, diet, nutrition and infection management must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific placebo contents/appearance, no-supplement care and shared exposures/treatments remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "How was newly diagnosed pneumonia defined?",
      "needed": "Pneumonia diagnostic criteria, exclusion of existing pneumonia, assessment and event timing",
      "role": "Required",
      "role_reason": "Material on Pneumonia diagnostic criteria, exclusion of existing pneumonia, assessment and event timing is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Pneumonia diagnostic criteria, exclusion of existing pneumonia, assessment and event timing must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial diagnostic criteria, imaging/clinical tests, assessors, exclusion of existing pneumonia and event timing are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are recovery and treatment of existing pneumonia the same outcome?",
      "needed": "Separation of preventive exposure/new incidence from treatment, recovery and duration of existing pneumonia",
      "role": "Required",
      "role_reason": "Material on Separation of preventive exposure/new incidence from treatment, recovery and duration of existing pneumonia is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Separation of preventive exposure/new incidence from treatment, recovery and duration of existing pneumonia must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Treatment duration, recovery and severity outcomes for existing pneumonia are not established as direct evidence for this prevention question. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Can colds or composite respiratory outcomes be read as pneumonia events?",
      "needed": "Disease-specific events/denominators, pneumonia extraction and composite-outcome components/definitions",
      "role": "Required",
      "role_reason": "Material on Disease-specific events/denominators, pneumonia extraction and composite-outcome components/definitions is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Disease-specific events/denominators, pneumonia extraction and composite-outcome components/definitions must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Disease-specific events/denominators, pneumonia extraction and composite-outcome components/definitions are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Did early and late VAP include the same patients?",
      "needed": "Patient/event units, early/late overlap, time at risk and total denominator",
      "role": "Supplementary; required when extending to VAP events",
      "role_reason": "Material on Patient/event units, early/late overlap, time at risk and total denominator is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Patient/event units, early/late overlap, time at risk and total denominator must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original patient/event lists, overlap, time at risk and total denominator remain unverified. This supplementary item becomes required when extending to VAP events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is stored about the marine-recruit trial?",
      "needed": "Pitt·Costrini 1979, blinded prevention trial, abstract 674 and unadopted original events",
      "role": "Required",
      "role_reason": "Material on Pitt·Costrini 1979, blinded prevention trial, abstract 674 and unadopted original events is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Pitt·Costrini 1979, blinded prevention trial, abstract 674 and unadopted original events must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Overall allocation, exclusions, pneumonia denominators, original-paper pneumonia events/CI and prespecified endpoint hierarchy are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What kind of count is the reported 674 people?",
      "needed": "Separation of abstract counts from allocation, exclusion, completer, analysis and pneumonia denominators",
      "role": "Required",
      "role_reason": "Material on Separation of abstract counts from allocation, exclusion, completer, analysis and pneumonia denominators is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Separation of abstract counts from allocation, exclusion, completer, analysis and pneumonia denominators must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Group allocation, completer/pneumonia denominators and eligible-event mapping are needed; 674 is also not used as a harm denominator. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Why were the review’s 1 versus 7 events not adopted?",
      "needed": "Review counts versus original-trial direct events, denominators, CI and the nonadoption decision",
      "role": "Required",
      "role_reason": "Material on Review counts versus original-trial direct events, denominators, CI and the nonadoption decision is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Review counts versus original-trial direct events, denominators, CI and the nonadoption decision must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original-trial direct events, denominators, CI and review-extraction/original-table mapping are needed. Totals, effects and intervals are not calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "How do historical abstract checking and failed comparison differ from current reading?",
      "needed": "Separation of historical searching, abstract and comparison records from current stored-summary reading",
      "role": "Required",
      "role_reason": "Material on Separation of historical searching, abstract and comparison records from current stored-summary reading is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Separation of historical searching, abstract and comparison records from current stored-summary reading must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Only the stored summary was read here; external abstract/full-text access was not attempted. Historical failure is not labeled as a current access failure. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What result do Cochrane’s RR 0.46 and CI describe?",
      "needed": "Pooled RR, 95% CI, events, denominators and extraction for 2 prevention studies",
      "role": "Required",
      "role_reason": "Material on Pooled RR, 95% CI, events, denominators and extraction for 2 prevention studies is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Pooled RR, 95% CI, events, denominators and extraction for 2 prevention studies must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The original forest plot, study-specific events/denominators, weights, prevention subgroup analysis and methods remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Do 2 prevention studies and two citations mean the same count?",
      "needed": "Original trials, reviews, citations, included prevention trials, report families and participant overlap",
      "role": "Required",
      "role_reason": "Material on Original trials, reviews, citations, included prevention trials, report families and participant overlap is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original trials, reviews, citations, included prevention trials, report families and participant overlap must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact inclusion/family mapping of the 2 prevention trials, Pitt review inclusion/extraction and unique participant totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "How are prevention data separated within a prevention/treatment review?",
      "needed": "Review prevention/treatment, route, population, inclusion and extraction scope",
      "role": "Required",
      "role_reason": "Material on Review prevention/treatment, route, population, inclusion and extraction scope is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Review prevention/treatment, route, population, inclusion and extraction scope must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The review’s prevention/treatment and route-specific inclusion lists, timing, denominators and mapping to the stored pooled estimate are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "How does the review’s search scope differ from the manuscript date?",
      "needed": "Search sources, strategy, dates, eligibility, selection, unpublished materials and manuscript date",
      "role": "Required",
      "role_reason": "Material on Search sources, strategy, dates, eligibility, selection, unpublished materials and manuscript date is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Search sources, strategy, dates, eligibility, selection, unpublished materials and manuscript date must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The review’s actual search cutoff, strategy, selection flow, unpublished/registry search and the manuscript’s evidence-search scope remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Was pneumonia a prespecified primary endpoint in the original trial?",
      "needed": "Registration, protocol, analysis plan and the hierarchy of respiratory outcomes and pneumonia",
      "role": "Required",
      "role_reason": "Material on Registration, protocol, analysis plan and the hierarchy of respiratory outcomes and pneumonia is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Registration, protocol, analysis plan and the hierarchy of respiratory outcomes and pneumonia must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original plans, registration, pneumonia prespecification, analyses and timing-change records are needed. The page’s selected endpoint does not verify prespecification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What were the original trials’ allocation structures and baseline balance?",
      "needed": "Allocation units, random sequence, concealment, baseline nutrition and exposure balance",
      "role": "Required",
      "role_reason": "Material on Allocation units, random sequence, concealment, baseline nutrition and exposure balance is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Allocation units, random sequence, concealment, baseline nutrition and exposure balance must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific allocation units, sequence, concealment, baseline balance and randomization mapping are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How were double blinding and pneumonia detection conducted?",
      "needed": "Role-specific blinding, placebo, assessors, pneumonia diagnosis, detection and classification",
      "role": "Required",
      "role_reason": "Material on Role-specific blinding, placebo, assessors, pneumonia diagnosis, detection and classification is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Role-specific blinding, placebo, assessors, pneumonia diagnosis, detection and classification must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Who was blinded, pneumonia diagnosis/interpretation/detection and differences in respiratory-disease classification or surveillance remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How did actual supplementation, training and infection management differ?",
      "needed": "Supplement use, deviations, diet, training, environment, concurrent treatment and shared care",
      "role": "Required",
      "role_reason": "Material on Supplement use, deviations, diet, training, environment, concurrent treatment and shared care is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Supplement use, deviations, diet, training, environment, concurrent treatment and shared care must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Adherence, changes, training, environment, diet, concurrent treatment, management differences and analysis handling are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Who was missing from pneumonia-incidence assessment?",
      "needed": "Allocation, exclusions, pneumonia analysis, attrition, follow-up time, ITT/PP and missing data",
      "role": "Required",
      "role_reason": "Material on Allocation, exclusions, pneumonia analysis, attrition, follow-up time, ITT/PP and missing data is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Allocation, exclusions, pneumonia analysis, attrition, follow-up time, ITT/PP and missing data must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific exclusions, attrition/reasons, completed pneumonia assessment, follow-up time, ITT/PP and missing-data handling are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How was the RR pooled across the two prevention studies?",
      "needed": "Individual effects, events, denominators, model, weights, heterogeneity and analysis units",
      "role": "Required",
      "role_reason": "Material on Individual effects, events, denominators, model, weights, heterogeneity and analysis units is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Individual effects, events, denominators, model, weights, heterogeneity and analysis units must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original individual effects/counts, model, weights, I²/τ², zero-event/cluster handling and prediction intervals are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Does very low certainty represent a new official assessment here?",
      "needed": "The original review’s certainty, risk assessment, tools, domains and downgrading reasons",
      "role": "Required",
      "role_reason": "Material on The original review’s certainty, risk assessment, tools, domains and downgrading reasons is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on The original review’s certainty, risk assessment, tools, domains and downgrading reasons must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original GRADE/RoB tables, domains and downgrading reasons are unread; no new official assessment was performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What uncertainty remains with RR 0.46 and the wide 0.06 to 3.61 interval?",
      "needed": "Original events, denominators, effect interval, prespecified important difference and interpretation scope",
      "role": "Required",
      "role_reason": "Material on Original events, denominators, effect interval, prespecified important difference and interpretation scope is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original events, denominators, effect interval, prespecified important difference and interpretation scope must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original counts, exact effect of interest, prespecified important difference, interval method and population-specific precision remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Can the absolute preventive effect in the general population be determined?",
      "needed": "Population-specific baseline risk, events, denominators, absolute differences and patient importance",
      "role": "Required",
      "role_reason": "Material on Population-specific baseline risk, events, denominators, absolute differences and patient importance is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Population-specific baseline risk, events, denominators, absolute differences and patient importance must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Baseline pneumonia risk, absolute differences, NNT, importance and persistence for the general population or current target group remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "How are original trials, reviews and independent replication distinguished?",
      "needed": "Report families, the review’s prevention subset, same trials, teams and unique participants",
      "role": "Required",
      "role_reason": "Material on Report families, the review’s prevention subset, same trials, teams and unique participants is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Report families, the review’s prevention subset, same trials, teams and unique participants must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Direct replication for the same route/population/endpoint, review-inclusion mapping and unique trial/team/participant counts remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "What supported the original trial and the review?",
      "needed": "Cash, products, manufacturers, employment, authors, COI and analysis roles",
      "role": "Required",
      "role_reason": "Material on Cash, products, manufacturers, employment, authors, COI and analysis roles is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Cash, products, manufacturers, employment, authors, COI and analysis roles must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific cash/product support, affiliations, COI and analysis/manufacturing roles are needed. Unverified is not converted into no involvement. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "What bibliographic identities and materials actually read are recorded?",
      "needed": "PMID, DOI, registration, original-trial/review URLs, stored summaries and unread external materials",
      "role": "Required",
      "role_reason": "Material on PMID, DOI, registration, original-trial/review URLs, stored summaries and unread external materials is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on PMID, DOI, registration, original-trial/review URLs, stored summaries and unread external materials must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: External abstracts, full text, registration, plans, supplements and the full review are unread; access was not attempted. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "What do 2026-09-07 and empty correction records mean?",
      "needed": "Separation of evidence date, publication dates, review dates, correction records and preparation date",
      "role": "Required",
      "role_reason": "Material on Separation of evidence date, publication dates, review dates, correction records and preparation date is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Separation of evidence date, publication dates, review dates, correction records and preparation date must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: There is no current search, external-reading or clinical-review completion date; the original material’s search cutoff also remains unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "How are nonadoption and historical records retained across languages?",
      "needed": "674, prespecification, unadopted events, pooled estimates, prevention/treatment and existing question boundaries",
      "role": "Required",
      "role_reason": "Material on 674, prespecification, unadopted events, pooled estimates, prevention/treatment and existing question boundaries is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on 674, prespecification, unadopted events, pooled estimates, prevention/treatment and existing question boundaries must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Detailed Korean/English correspondence to external original material remains unreviewed. Correction of original material remains separate from this reader translation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "What do C·54 points and existing assessment values represent?",
      "needed": "Original grade, score, caution, assessment values, verdict history and presence of human research",
      "role": "Required",
      "role_reason": "Material on Original grade, score, caution, assessment values, verdict history and presence of human research is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original grade, score, caution, assessment values, verdict history and presence of human research must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: No current external clinical validation or official methodological certification was performed. Unverified original events are not converted into absence of human research. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "How were harms collected in high-dose oral trials?",
      "needed": "Definitions of diarrhea/abdominal discomfort, group events, denominators, discontinuation, missing data and duration",
      "role": "Required",
      "role_reason": "Material on Definitions of diarrhea/abdominal discomfort, group events, denominators, discontinuation, missing data and duration is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Definitions of diarrhea/abdominal discomfort, group events, denominators, discontinuation, missing data and duration must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific event counts, collection methods, group harm denominators, discontinuation, missing data and timing are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "What is known about harm onset, recovery and alternative exposures?",
      "needed": "Event timing, changes after stopping, re-exposure, baseline disease, concomitant exposures and other causes",
      "role": "Required",
      "role_reason": "Material on Event timing, changes after stopping, re-exposure, baseline disease, concomitant exposures and other causes is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Event timing, changes after stopping, re-exposure, baseline disease, concomitant exposures and other causes must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Individual event timing, improvement after stopping, re-exposure, concomitant nutrition, disease and other causes remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "What remains unknown about stones, kidney disease, iron overload and long-term/rare harms?",
      "needed": "Caution groups, formulation, exposure, actual events, denominators, long-term, rare and concomitant harms",
      "role": "Supplementary; required for the corresponding harm/long-term claim",
      "role_reason": "Material on Caution groups, formulation, exposure, actual events, denominators, long-term, rare and concomitant harms is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Caution groups, formulation, exposure, actual events, denominators, long-term, rare and concomitant harms must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Population-specific actual events/denominators and long-term, rare and concomitant harms remain unverified. This supplementary item is required for the corresponding harm/long-term claim. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "Were harms from the same oral exposure repeated in independent materials?",
      "needed": "Unique cases, report families, exposure/event agreement and repeated citation",
      "role": "Supplementary; required for a repeated-harm claim",
      "role_reason": "Material on Unique cases, report families, exposure/event agreement and repeated citation is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Unique cases, report families, exposure/event agreement and repeated citation must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Independent harm cases/families, exposure/event agreement, denominators and replication remain unverified. This supplementary item is required for a repeated-harm claim. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "How do the summaries read connect to original material still needed?",
      "needed": "Material-specific acquisition, reading, original sources, criteria/evidence changes and original preservation",
      "role": "Required",
      "role_reason": "Material on Material-specific acquisition, reading, original sources, criteria/evidence changes and original preservation is needed to connect the selected oral prevention question to its population, formulation, baseline nutrition, comparison, new pneumonia diagnosis, events, denominators, follow-up, precision and harms.",
      "application_exception": "Oral prevention remains separate from treatment of existing pneumonia, intravenous dosing, colds and composite respiratory outcomes. Abstract population counts, allocation/pneumonia/harm denominators, original-trial events, unadopted review counts, pooled estimates and individual effects are not mixed; no new effects, intervals, incidence rates, absolute differences, NNTs, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Material-specific acquisition, reading, original sources, criteria/evidence changes and original preservation must link to the same prevention question, route, population, comparison, diagnosis, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, populations, routes, prevention and treatment, trials and reviews, events, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C for preventing new pneumonia in high-stress or low-intake populations. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Original events, denominators, diagnosis, plans, review inclusion, methods, harms, support materials and clinical content review remain outstanding. This records needed materials; no new research was executed."
    }
  ]
}