{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Perioperative Oral Vitamin C for Postoperative Atrial Fibrillation—Results Are Inconsistent",
  "language": "en",
  "translation_date": "2026-10-22",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What is the scope of the oral POAF prevention question?",
      "needed": "Perioperative oral single-ingredient C; new POAF; background prophylaxis; comparison",
      "role": "Required",
      "role_reason": "Material on Perioperative oral single-ingredient C; new POAF; background prophylaxis; comparison is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Perioperative oral single-ingredient C; new POAF; background prophylaxis; comparison must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Intravenous or mixed routes, shorter hospital stay and prevention across all surgical populations are not converted into the same question. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How does current reading differ from historical checks?",
      "needed": "Stored summaries; historical abstract/cross-check records; current external material",
      "role": "Required",
      "role_reason": "Material on Stored summaries; historical abstract/cross-check records; current external material is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Stored summaries; historical abstract/cross-check records; current external material must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: External papers, registration, protocols and SAPs are currently unread and access was not attempted. Bibliographic links and historical verification are not promoted to current reading of original material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What identifies the main oral null report?",
      "needed": "Bjordahl 2012 title; PMID/DOI; report and trial linkage",
      "role": "Required",
      "role_reason": "Material on Bjordahl 2012 title; PMID/DOI; report and trial linkage is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Bjordahl 2012 title; PMID/DOI; report and trial linkage must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The full original paper, registration, initial allocation, exact dose and report-identity linkage remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What is the older positive oral add-on report?",
      "needed": "Eslami 2007; oral C plus beta-blocker; 100 participants; comparison",
      "role": "Required",
      "role_reason": "Material on Eslami 2007; oral C plus beta-blocker; 100 participants; comparison is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Eslami 2007; oral C plus beta-blocker; 100 participants; comparison must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact events, denominators, intervals, modern background care and registration boundaries remain unverified and are not filled with values from the main null report. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What is the 2023 registered oral report?",
      "needed": "253 participants; oral schedule; PMID/registration; complete bibliography",
      "role": "Required",
      "role_reason": "Material on 253 participants; oral schedule; PMID/registration; complete bibliography is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on 253 participants; oral schedule; PMID/registration; complete bibliography must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: A generic title is not converted into full original-bibliography verification. Registry contents, change history, denominators and COI remain currently unread or unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are reports, participants and events kept separate?",
      "needed": "185 completers; 100 participants; 253 participants; analysis and reporting relationships",
      "role": "Required",
      "role_reason": "Material on 185 completers; 100 participants; 253 participants; analysis and reporting relationships is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on 185 completers; 100 participants; 253 participants; analysis and reporting relationships must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Initial allocation and denominator types differ or remain unverified; no new participant total, unique trial count, independent-replication count or POAF event total is summed or established. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What are the surgical and baseline-population boundaries?",
      "needed": "Elective on-pump CABG; surgery; baseline rhythm/risk; eligibility",
      "role": "Required",
      "role_reason": "Material on Elective on-pump CABG; surgery; baseline rhythm/risk; eligibility is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Elective on-pump CABG; surgery; baseline rhythm/risk; eligibility must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific surgery, pre-existing arrhythmia, age, risk, eligibility/exclusions and applicability to other operations remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are oral and IV formulations distinguished?",
      "needed": "Oral ascorbic acid; formulation/components; IV kept separate",
      "role": "Required",
      "role_reason": "Material on Oral ascorbic acid; formulation/components; IV kept separate is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral ascorbic acid; formulation/components; IV kept separate must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: IV or mixed-route results and product specifications are not transferred to oral formulations. Oral tablet/solution, salt, excipients and manufacturing details remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Are IV doses kept separate from oral reports?",
      "needed": "Original IV A2/A3 labels; actual dose in each oral report",
      "role": "Required",
      "role_reason": "Material on Original IV A2/A3 labels; actual dose in each oral report is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original IV A2/A3 labels; actual dose in each oral report must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The original A2/A3 labels are not automatically mapped to current oral S02/S03 or used as oral doses. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What is the 2023 oral dose and schedule?",
      "needed": "1 g 2 times daily; 5 days before through 10 days after surgery; actual use/adherence",
      "role": "Required",
      "role_reason": "Material on 1 g 2 times daily; 5 days before through 10 days after surgery; actual use/adherence is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on 1 g 2 times daily; 5 days before through 10 days after surgery; actual use/adherence must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The original general duration of about 5 days is not applied to this report. Cumulative dose, total days and actual adherence are not newly calculated or filled as verified values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are older oral doses and durations verified?",
      "needed": "S01/S02 oral doses; perioperative schedules; actual exposure",
      "role": "Required",
      "role_reason": "Material on S01/S02 oral doses; perioperative schedules; actual exposure is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on S01/S02 oral doses; perioperative schedules; actual exposure must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Older oral doses and durations are not filled with IV schedules or the S03 dose. Actual adherence and adjustments remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Is the effect additional to background prophylaxis?",
      "needed": "Beta-blocker; amiodarone; common care; changes/rescue",
      "role": "Required",
      "role_reason": "Material on Beta-blocker; amiodarone; common care; changes/rescue is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Beta-blocker; amiodarone; common care; changes/rescue must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific drug types, doses, amiodarone use, group changes, rescue treatment, balance and correspondence to modern care remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are placebo and usual-prophylaxis comparisons distinguished?",
      "needed": "Placebo components; masking; usual care; comparison direction",
      "role": "Required",
      "role_reason": "Material on Placebo components; masking; usual care; comparison direction is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Placebo components; masking; usual care; comparison direction must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Reports are not all converted into the same placebo comparison. Placebo and control details remain separately unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "How far are allocation, concealment and masking verified?",
      "needed": "Report-specific sequence generation; concealment; masked parties; baseline balance",
      "role": "Required",
      "role_reason": "Material on Report-specific sequence generation; concealment; masked parties; baseline balance is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Report-specific sequence generation; concealment; masked parties; baseline balance must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Design labels alone do not verify allocation, concealment, maintenance of masking or baseline balance. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "How were POAF/flutter events defined?",
      "needed": "New AF/flutter; duration threshold; surveillance method/window; assessment",
      "role": "Required",
      "role_reason": "Material on New AF/flutter; duration threshold; surveillance method/window; assessment is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on New AF/flutter; duration threshold; surveillance method/window; assessment must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific AF/flutter grouping, duration thresholds, continuous/intermittent monitoring, masking, time windows and post-discharge events remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What denominators are 185 completers and 89/96?",
      "needed": "Initial allocation; completion; POAF/analysis; group attrition",
      "role": "Required",
      "role_reason": "Material on Initial allocation; completion; POAF/analysis; group attrition is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Initial allocation; completion; POAF/analysis; group attrition must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Completer counts are not converted into randomization. Group event and analysis denominators, attrition and missingness remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What does 30.3% versus 30.2% describe?",
      "needed": "S01 reported rates; P; group events/denominators; interval",
      "role": "Required",
      "role_reason": "Material on S01 reported rates; P; group events/denominators; interval is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on S01 reported rates; P; group events/denominators; interval must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Event counts are not back-calculated from rounded rates. Exact95%CI, effects in the randomized population and original testing remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What do the positive and null S02/S03 findings establish?",
      "needed": "Each event/denominator; effect/CI; prespecified analysis; wording scope",
      "role": "Required",
      "role_reason": "Material on Each event/denominator; effect/CI; prespecified analysis; wording scope is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Each event/denominator; effect/CI; prespecified analysis; wording scope must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Exact event counts, group denominators, effects, P values and CIs are not newly created. Directional wording is not converted into precise estimates. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "How were analysis populations, attrition and rescue handled?",
      "needed": "ITT/PP/completers; missingness; attrition; concurrent changes/adjustment",
      "role": "Required",
      "role_reason": "Material on ITT/PP/completers; missingness; attrition; concurrent changes/adjustment is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on ITT/PP/completers; missingness; attrition; concurrent changes/adjustment must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific ITT/PP, reasons for missingness/attrition, rescue, adjustment and sensitivity analyses remain unverified. Total sample sizes do not fill analysis denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What is the scope of nonsignificance and sample-size criticism?",
      "needed": "Original CI; important effect; sample-size plan; target/details of criticism",
      "role": "Required",
      "role_reason": "Material on Original CI; important effect; sample-size plan; target/details of criticism is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Original CI; important effect; sample-size plan; target/details of criticism must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The target, bibliography and calculation details of the criticism are not linked in this summary. No current reading of the commentary or recalculation was performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are registration, prespecified endpoints and SAPs verified?",
      "needed": "Registration; change history; endpoint/time-point/analysis hierarchy",
      "role": "Required",
      "role_reason": "Material on Registration; change history; endpoint/time-point/analysis hierarchy is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Registration; change history; endpoint/time-point/analysis hierarchy must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: An identifier alone does not verify endpoint prespecification or agreement with plans. Registration, protocols and SAPs are currently unread. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are commentary, withdrawn registration and publication retraction distinguished?",
      "needed": "Event type; target identity; original material; historical search scope",
      "role": "Required",
      "role_reason": "Material on Event type; target identity; original material; historical search scope is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Event type; target identity; original material; historical search scope must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Current integrity of all literature is not guaranteed. Unlinked targets or original material are not newly verified or converted into a claim that everything is problem-free. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are conflicting directions retained by their conditions?",
      "needed": "Oral positive/null findings; surgery; background care; events/baseline risk",
      "role": "Required",
      "role_reason": "Material on Oral positive/null findings; surgery; background care; events/baseline risk is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral positive/null findings; surgery; background care; events/baseline risk must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Route, prophylaxis, event and regional differences are not erased, and results are not newly pooled or established as independent replication. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Can findings be generalized across surgery, region, duration and dose?",
      "needed": "Surgery/region; dose; background drugs; long-term/prespecified subgroup hypotheses",
      "role": "Required",
      "role_reason": "Material on Surgery/region; dose; background drugs; long-term/prespecified subgroup hypotheses is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Surgery/region; dose; background drugs; long-term/prespecified subgroup hypotheses must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Effects across all cardiac operations, other doses, long-term/post-discharge prevention and prespecified subgroups remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are hospital stay and other clinical outcomes kept separate?",
      "needed": "POAF; hospital stay; complications; quality of life; other outcome boundaries",
      "role": "Required",
      "role_reason": "Material on POAF; hospital stay; complications; quality of life; other outcome boundaries is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on POAF; hospital stay; complications; quality of life; other outcome boundaries must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Separate effects on stroke, death, quality of life or readmission, and treatment of existing AF, do not fill the current POAF question. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "How far are funding, products, authorship and COI verified?",
      "needed": "Funding; free/product support; employment; patents; original COI material",
      "role": "Required",
      "role_reason": "Material on Funding; free/product support; employment; patents; original COI material is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Funding; free/product support; employment; patents; original COI material must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: The existing I2 and independent cross-check are not inherited as current item-specific verification. Funding, products, employment and COI remain separately unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What is the actual level of harm collection?",
      "needed": "Oral C events; collection; discontinuation; exposure/event/time denominators",
      "role": "Supplementary",
      "role_reason": "Material on Oral C events; collection; discontinuation; exposure/event/time denominators is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral C events; collection; discontinuation; exposure/event/time denominators must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Group harms, collection, discontinuation and denominators remain unverified. POAF prevention or null results do not determine safety. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What are the surgery, concomitant-treatment, baseline-risk and harm timelines?",
      "needed": "Surgery/prophylaxis; kidney/stone/iron-overload risk; onset/recovery; alternatives",
      "role": "Supplementary",
      "role_reason": "Material on Surgery/prophylaxis; kidney/stone/iron-overload risk; onset/recovery; alternatives is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Surgery/prophylaxis; kidney/stone/iron-overload risk; onset/recovery; alternatives must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Specific interactions, harm causality, between-group risk, recovery after stopping and re-exposure remain unverified. No new event counts or incidence rates were calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "What is known about long-term or rare harms and special populations?",
      "needed": "Long-term/rare events; direct exposure by underlying condition",
      "role": "Supplementary",
      "role_reason": "Material on Long-term/rare events; direct exposure by underlying condition is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term/rare events; direct exposure by underlying condition must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Limited event counts do not establish the absence of long-term or rare harms or safety in every special population. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "What are the original D34, assessment values, dates and empty corrections?",
      "needed": "Grade/score; assessment values; original evidence date; empty values; historical checks",
      "role": "Required",
      "role_reason": "Material on Grade/score; assessment values; original evidence date; empty values; historical checks is needed to connect the selected oral prevention question to its surgical population, formulation, dosing, background drugs, comparison, events, surveillance window, denominator, precision and harms.",
      "application_exception": "Oral and intravenous or mixed routes, allocation and completer/event denominators, and placebo versus add-on prophylaxis remain separate. Other routes’ doses, rounded rates, hospital stay, commentary or registry status do not substitute for oral effects, event counts, publication retraction or overall safety; no new effects, intervals, incidence rates, cumulative doses or individual dosing guidance are created.",
      "criterion": "Original records on Grade/score; assessment values; original evidence date; empty values; historical checks must link to the same oral route, surgical population, background drugs, comparison, event, time point and analysis population, distinguishing recorded information from gaps.",
      "basis": "Existing principles distinguish questions, routes, direct comparisons, reports and trials, background prophylaxis, event definitions, denominators, precision and harms.",
      "condition_origin": "These evidence conditions apply to the existing question of single-ingredient oral vitamin C around cardiac surgery for postoperative atrial fibrillation prevention. They link stored summaries and gaps without establishing new preregistration, official assessment or independent clinical validation.",
      "proposed_research": "Material needed: Historical wording about recent or verified evidence is not inherited as a new search. No new verdict or current literature-integrity certification is made. This records needed materials; no new research was executed."
    }
  ]
}