{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3021-main", "verdict_number": "3021", "title": "Oral Vitamin C After Distal-Radius Fracture or Surgery—CRPS-I Results Remain Conflicting", "view_version": "1.0", "view_created_date": "2026-10-22", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Conservatively treated wrist fractures, older fracture patients and adult surgical patients remain separate. Study-specific age, fracture type, displacement, surgery and eligibility are not generalized to every fracture or operation.", "intervention": "The record concerns oral single-ingredient ascorbic acid, a purified nutrient. Feedstock, manufacture and study-specific tablet/capsule, salt, excipients and product identity remain unverified. It is not extended to foods, combinations or intravenous infusion.", "dose": "The existing dose information is early 200/500/1500 mg/day for 50 days, 500 mg for 90 days in the independent trial, and 1 g for 60 days in the surgical trial. These grouped details are not automatically assigned as each report’s full specification without the original material, and no cumulative dose is newly calculated.", "comparator": "The original matched-placebo or standard-care context is retained without mixing surgical and conservative treatment. Immobilization, rehabilitation, analgesia, rescue treatment, additional supplements, adherence, group changes and their analytical handling remain unverified.", "endpoint": "The endpoint is diagnosed CRPS-I incidence. Older RSD/CRPS and Budapest criteria remain separate; DASH function, pain and neuropathic pain do not substitute for fewer diagnosed events. Primary and secondary endpoints and the official prespecified hierarchy also remain separate.", "duration": "Dosing for 50 days, 90 days and 60 days remains separate from follow-up of 1 year, 90 days and 24 weeks. The 2025 report’s 12-week and 24-week observations concern the same completer group; events and people are not summed.", "excluded_extensions": [ "This question concerns single-ingredient oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. It is not extended to every fracture, operation, other formulation, fracture union, quality-of-life benefit or individual dosing guidance.", "The existing grade C·54 points, stored assessment values, Korean and English explanations and evidence date 2026-09-07 are retained. Historical cross-check records do not establish current reading of original material, regrading or a completed comprehensive literature search.", "People and wrists, allocation and analysis, and initial samples and completers remain separate. Shared placebo groups, dose groups and denominators at two observation times are not double-counted, and an absence of events is not interpreted as guaranteed prevention.", "Older RSD/CRPS and Budapest criteria are not combined as the same diagnosis. The 2014 DASH primary endpoint, CRPS secondary endpoint and P=.022 in the 6-week nondisplaced subgroup remain separate from an overall prespecified primary harm outcome.", "The same core investigators in the 1999 and 2007 reports establish neither identical participants nor a reason to add independent replication. The 2025 English and Portuguese versions concern the same cohort and are not counted as two trials.", "The meta-analysis citation’s 3 trials and 890 participants are not counted as new direct trials or additional participants. The 2021 positive-study and 2022 guideline mentions lack individually linked exact citations and are not turned into new reports or an up-to-date guideline incorporating 2025.", "The original explanation that CAAE is an ethics-approval identifier is retained without promoting it to prospective trial registration. Exact endpoint hierarchy, registration changes, protocols, analysis plans and the content of any corrected table remain unverified.", "Existing caution about gastrointestinal discomfort, diarrhea, kidney disease, stone risk and iron overload with high oral vitamin C doses is retained. Limited event counts or CRPS results are not converted into an absence of harms or established safety, and no new incidence rate is calculated." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What is the original CRPS-I prevention question?", "needed": "Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up", "role": "Required", "role_reason": "Material on Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: It is not extended to guaranteed prevention for every fracture, operation, pain score or other formulation. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The selected claim is prevention of CRPS-I after distal-radius fracture or surgery. Surgery, conservative treatment, diagnostic criteria and duration remain separate.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "It is not extended to guaranteed prevention for every fracture, operation, pain score or other formulation.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "It is not extended to guaranteed prevention for every fracture, operation, pain score or other formulation." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "How does current reading differ from historical abstract or full-text checks?", "needed": "Stored JSON, historical HTML/abstract/cross-check records and current external materials", "role": "Required", "role_reason": "Material on Stored JSON, historical HTML/abstract/cross-check records and current external materials is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Stored JSON, historical HTML/abstract/cross-check records and current external materials must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External abstracts, full text, registration and plans are currently unread and access was not attempted. Historical reading is not inherited as current completion or clinical review. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing Korean and English stored summary was read. Historical citation records of abstract checking for S01–S03, original HTML/methods/tables/funding checks for S04 and cross-checking for S05 remain separate from current reading.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "External abstracts, full text, registration and plans are currently unread and access was not attempted. Historical reading is not inherited as current completion or clinical review.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External abstracts, full text, registration and plans are currently unread and access was not attempted. Historical reading is not inherited as current completion or clinical review." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What identifies the early 1999 report?", "needed": "Zollinger1999, PMID/DOI, conservative treatment and report/trial identity", "role": "Required", "role_reason": "Material on Zollinger1999, PMID/DOI, conservative treatment and report/trial identity is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Zollinger1999, PMID/DOI, conservative treatment and report/trial identity must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External original material, registration and related-report relationships were not checked here. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The conservatively treated wrist-fracture trial in Lancet 1999, PMID10636366 and DOI10.1016/S0140-6736(99)03059-7, is retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "External original material, registration and related-report relationships were not checked here.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External original material, registration and related-report relationships were not checked here." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "What kind of replication is the 2007 dose report?", "needed": "Shared core investigators, multicentre dose trial and PMID/DOI", "role": "Required", "role_reason": "Material on Shared core investigators, multicentre dose trial and PMID/DOI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Shared core investigators, multicentre dose trial and PMID/DOI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Shared investigators establish neither identical participants nor a basis for promotion to new independent replication. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "This is the Zollinger 2007 dose randomized trial, PMID17606778 and DOI10.2106/JBJS.F.01147. The original note about shared core investigators with S01 is retained without newly crediting independent replication.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Shared investigators establish neither identical participants nor a basis for promotion to new independent replication.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Shared investigators establish neither identical participants nor a basis for promotion to new independent replication." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What identifies the opposing 2014 report and its endpoint?", "needed": "Ekrol2014, PMID/DOI and DASH primary/CRPS secondary", "role": "Required", "role_reason": "Material on Ekrol2014, PMID/DOI and DASH primary/CRPS secondary is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Ekrol2014, PMID/DOI and DASH primary/CRPS secondary must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: CRPS is not promoted to the overall prespecified primary endpoint. Original registration, analysis plans, events and denominators remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The Ekrol 2014 independent double-blind placebo trial, PMID25187584 and DOI10.2106/JBJS.M.00268, randomized 336 people. DASH function was primary and CRPS secondary.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "CRPS is not promoted to the overall prespecified primary endpoint. Original registration, analysis plans, events and denominators remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "CRPS is not promoted to the overall prespecified primary endpoint. Original registration, analysis plans, events and denominators remain unverified." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What identifies the 2025 surgical report?", "needed": "English report, bibliography, initial/completer samples, masking and Budapest criteria", "role": "Required", "role_reason": "Material on English report, bibliography, initial/completer samples, masking and Budapest criteria is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on English report, bibliography, initial/completer samples, masking and Budapest criteria must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Online2025-08-25/eCollection2025-06 is publication metadata, not proof of prospective registration. Original material is currently unread. This records needed materials; no new research was executed.", "current_reports": [ "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The English de Azevedo Filho et al. 2025 surgical report, PMID40860294, PMCIDPMC12377947 and DOI10.1055/s-0045-1810402, is retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Online2025-08-25/eCollection2025-06 is publication metadata, not proof of prospective registration. Original material is currently unread.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Online2025-08-25/eCollection2025-06 is publication metadata, not proof of prospective registration. Original material is currently unread." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is the Portuguese version a separate independent trial?", "needed": "Language versions with different PMID/PMCID/DOI and the same-cohort relationship", "role": "Required", "role_reason": "Material on Language versions with different PMID/PMCID/DOI and the same-cohort relationship is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Language versions with different PMID/PMCID/DOI and the same-cohort relationship must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Different identifiers are not added as two trials or extra participants. The same-cohort relationship also remains limited to the stored narrative. This records needed materials; no new research was executed.", "current_reports": [ "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing manuscript describes Portuguese PMID40860295, PMCIDPMC12377946 and DOI10.1055/s-0045-1810403 as the same cohort.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Different identifiers are not added as two trials or extra participants. The same-cohort relationship also remains limited to the stored narrative.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Different identifiers are not added as two trials or extra participants. The same-cohort relationship also remains limited to the stored narrative." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Where does the meta-analysis fit?", "needed": "Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap", "role": "Required", "role_reason": "Material on Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The review is not counted as a new direct trial or 890 additional participants. Included trials, exact values and intervals are unread. This records needed materials; no new research was executed.", "current_reports": [ "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Evaniew 2015, PMID26197022, is an existing citation stating that the pooled interval from 3 trials with 890 participants includes no effect and heterogeneity is substantial. It remains separate from direct trial summaries.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The review is not counted as a new direct trial or 890 additional participants. Included trials, exact values and intervals are unread.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The review is not counted as a new direct trial or 890 additional participants. Included trials, exact values and intervals are unread." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "How far do the 2021 positive-study and 2022 guideline mentions extend?", "needed": "Original narrative mentions, exact citations/trials and time scope", "role": "Required", "role_reason": "Material on Original narrative mentions, exact citations/trials and time scope is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original narrative mentions, exact citations/trials and time scope must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Exact citations for the 2021 trial and guideline are not individually linked. The 2022 document is not described as a definitive current guideline incorporating 2025. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing narrative describes independent positive findings in 2021 and 2025 and an unproven prevention benefit in the 2022 guideline.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Exact citations for the 2021 trial and guideline are not individually linked. The 2022 document is not described as a definitive current guideline incorporating 2025.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact citations for the 2021 trial and guideline are not individually linked. The 2022 document is not described as a definitive current guideline incorporating 2025." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are conservative, older-fracture and adult surgical populations the same?", "needed": "Surgery status, age, fracture type/displacement, eligibility and baseline", "role": "Required", "role_reason": "Material on Surgery status, age, fracture type/displacement, eligibility and baseline is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Surgery status, age, fracture type/displacement, eligibility and baseline must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report-specific age, fracture, surgery, eligibility and mixture proportions remain unverified. Findings are not generalized to every operation or fracture. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Existing population information treats conservative wrist fractures, older fracture patients and adult surgery separately. S01 concerns conservative treatment and S04 surgery.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Report-specific age, fracture, surgery, eligibility and mixture proportions remain unverified. Findings are not generalized to every operation or fracture.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific age, fracture, surgery, eligibility and mixture proportions remain unverified. Findings are not generalized to every operation or fracture." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "What are the purified nutrient and oral formulation?", "needed": "Single C, oral route, salts/excipients, feedstock and manufacture", "role": "Required", "role_reason": "Material on Single C, oral route, salts/excipients, feedstock and manufacture is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Single C, oral route, salts/excipients, feedstock and manufacture must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Study-specific tablet/capsule, salt, excipients and product identity remain unverified. They are not replaced by combinations, foods or intravenous infusion. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The record concerns oral single-ingredient ascorbic acid, a purified nutrient. Plant part is not applicable; unverified feedstock and manufacture are retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Study-specific tablet/capsule, salt, excipients and product identity remain unverified. They are not replaced by combinations, foods or intravenous infusion.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Study-specific tablet/capsule, salt, excipients and product identity remain unverified. They are not replaced by combinations, foods or intravenous infusion." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "How do dosing and follow-up differ between trials?", "needed": "200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up", "role": "Required", "role_reason": "Material on 200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Grouped dose details are not automatically assigned as each report’s full specification. No cumulative amount or duration is newly calculated without original material. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Existing dose information distinguishes early 200/500/1500 mg/day for 50 days, 500 mg for 90 days in the independent trial and surgical 1 g for 60 days, from follow-up of 1 year/90 days/24 weeks.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Grouped dose details are not automatically assigned as each report’s full specification. No cumulative amount or duration is newly calculated without original material.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Grouped dose details are not automatically assigned as each report’s full specification. No cumulative amount or duration is newly calculated without original material." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are people and wrists distinguished?", "needed": "S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists", "role": "Required", "role_reason": "Material on S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Wrist events are not converted into person events, and laterality, bilateral involvement, clustering, allocation or exclusion handling is not inferred. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S01 allocated 123 people/127 wrists and analyzed 115 people/119 wrists; C52 people/54 wrists versus placebo 63 people/65 wrists.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Wrist events are not converted into person events, and laterality, bilateral involvement, clustering, allocation or exclusion handling is not inferred.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Wrist events are not converted into person events, and laterality, bilateral involvement, clustering, allocation or exclusion handling is not inferred." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What are the 1999 events and original risk difference?", "needed": "4/54 versus 14/65 wrists, reported risk difference and original interval", "role": "Required", "role_reason": "Material on 4/54 versus 14/65 wrists, reported risk difference and original interval is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 4/54 versus 14/65 wrists, reported risk difference and original interval must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Rounding differences in raw proportions are not concealed. Effect direction, models and person-level intervals are not newly inferred or recalculated. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The original 4/54 versus 14/65 wrists and paper-reported risk difference 15 percentage points(95%CI2–26) are retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Rounding differences in raw proportions are not concealed. Effect direction, models and person-level intervals are not newly inferred or recalculated.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Rounding differences in raw proportions are not concealed. Effect direction, models and person-level intervals are not newly inferred or recalculated." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "What are the 2007 people, wrist and dose denominators?", "needed": "416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists", "role": "Required", "role_reason": "Material on 416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Dose groups are not made into independent trials, and the shared placebo 99 wrists are not repeatedly summed. Clustering and analysis-unit correspondence remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S02 reports 416 people/427 wrists, C317 people/328 wrists and placebo 99 people/99 wrists. Dose-group wrist denominators 96/114/118 are retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Dose groups are not made into independent trials, and the shared placebo 99 wrists are not repeatedly summed. Clustering and analysis-unit correspondence remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Dose groups are not made into independent trials, and the shared placebo 99 wrists are not repeatedly summed. Clustering and analysis-unit correspondence remain unverified." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "What are the overall and dose-specific 2007 effects?", "needed": "8/328 versus 10/99, P and 200/500/1500 RR/95%CI", "role": "Required", "role_reason": "Material on 8/328 versus 10/99, P and 200/500/1500 RR/95%CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 8/328 versus 10/99, P and 200/500/1500 RR/95%CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The inclusion of no effect in the 200 mg interval is retained. No conclusion that higher doses are always better, new pooling or new difference is created. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The original overall 8/328 versus 10/99, P=.002; 200 mg 4/96 RR.41(95%CI.13–1.27), 500 mg 2/114 RR.17(.04–.77) and 1500 mg 2/118 RR.17(.04–.75) are retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The inclusion of no effect in the 200 mg interval is retained. No conclusion that higher doses are always better, new pooling or new difference is created.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The inclusion of no effect in the 200 mg interval is retained. No conclusion that higher doses are always better, new pooling or new difference is created." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are older RSD/CRPS and Budapest definitions separated?", "needed": "Report-specific diagnosis, criteria, assessors and time window", "role": "Required", "role_reason": "Material on Report-specific diagnosis, criteria, assessors and time window is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Report-specific diagnosis, criteria, assessors and time window must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: They are not combined as the same event diagnosis or relabelled as Budapest criteria. Assessors, masking and misclassification remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S01’s unverified detailed older RSD/CRPS criteria, S02’s older criteria and S04’s Budapest CRPS remain separate.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "They are not combined as the same event diagnosis or relabelled as Budapest criteria. Assessors, masking and misclassification remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "They are not combined as the same event diagnosis or relabelled as Budapest criteria. Assessors, masking and misclassification remain unverified." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "What is the scope of the 2014 analysis and 1-year null finding?", "needed": "336 randomized, CRPS secondary, 1 year, events/denominators/CI", "role": "Required", "role_reason": "Material on 336 randomized, CRPS secondary, 1 year, events/denominators/CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 336 randomized, CRPS secondary, 1 year, events/denominators/CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Analysis and event denominators, effects/CI and DASH results are not filled in. A large allocation count is not converted into precise proof of no effect. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S03 retains 336 randomized people and the original finding of no demonstrated 1-year CRPS benefit. CRPS was secondary.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Analysis and event denominators, effects/CI and DASH results are not filled in. A large allocation count is not converted into precise proof of no effect.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Analysis and event denominators, effects/CI and DASH results are not filled in. A large allocation count is not converted into precise proof of no effect." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Is harm in the 6-week nondisplaced subgroup kept within scope?", "needed": "S03 time point, subgroup, prespecification and interaction", "role": "Supplementary", "role_reason": "Material on S03 time point, subgroup, prespecification and interaction is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on S03 time point, subgroup, prespecification and interaction must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: It is not extended to overall or 1-year harm or definitive causality. Events, denominators, prespecified subgroups, multiplicity and interactions remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The increase in CRPS in the 6-week nondisplaced subgroup, P=.022, is retained with the original limit that it is not an overall prespecified primary harm result.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "It is not extended to overall or 1-year harm or definitive causality. Events, denominators, prespecified subgroups, multiplicity and interactions remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "It is not extended to overall or 1-year harm or definitive causality. Events, denominators, prespecified subgroups, multiplicity and interactions remain unverified." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What are the initial, completer and group denominators in 2025?", "needed": "Initial137→122 completers, C58/placebo 64, original allocation and losses", "role": "Required", "role_reason": "Material on Initial137→122 completers, C58/placebo 64, original allocation and losses is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Initial137→122 completers, C58/placebo 64, original allocation and losses must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: 137 is not converted into a confirmed randomized count. Reasons for loss, group allocation, missing data and ITT/PP remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S04 reports an initial sample 137→122 completers(C58/placebo 64). Original randomized group denominators remain unverified.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "137 is not converted into a confirmed randomized count. Reasons for loss, group allocation, missing data and ITT/PP remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "137 is not converted into a confirmed randomized count. Reasons for loss, group allocation, missing data and ITT/PP remain unverified." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are 2025 events at 12 and 24 weeks retained separately?", "needed": "Budapest events, the same completer group, each time point and P/CI", "role": "Required", "role_reason": "Material on Budapest events, the same completer group, each time point and P/CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Budapest events, the same completer group, each time point and P/CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Events and people at the two times are not summed, and an absence of events is not interpreted as 100% prevention. Between-group 95%CI is unreported/unverified. This records needed materials; no new research was executed.", "current_reports": [ "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The original 12-week 0/58 versus 7/64, P=.014; 24-week 0/58 versus 8/64, P=.007 are retained separately.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Events and people at the two times are not summed, and an absence of events is not interpreted as 100% prevention. Between-group 95%CI is unreported/unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Events and people at the two times are not summed, and an absence of events is not interpreted as 100% prevention. Between-group 95%CI is unreported/unverified." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "How far does the 2025 table-denominator typo record extend?", "needed": "Original table, typo location, correction/explanation and result denominator", "role": "Required", "role_reason": "Material on Original table, typo location, correction/explanation and result denominator is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original table, typo location, correction/explanation and result denominator must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The specific table, cell, typo and any official correction are absent from the stored summary. The original table was not read or changed here, and no new denominator is inferred. This records needed materials; no new research was executed.", "current_reports": [ "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing English summary for S04 mentions a table-denominator typo.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "The specific table, cell, typo and any official correction are absent from the stored summary. The original table was not read or changed here, and no new denominator is inferred.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The specific table, cell, typo and any official correction are absent from the stored summary. The original table was not read or changed here, and no new denominator is inferred." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "What is the actual scope of trial design, allocation and masking?", "needed": "Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance", "role": "Required", "role_reason": "Material on Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Design labels do not verify all allocation, concealment, maintenance of masking or baseline balance. Original methods are unread. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Original descriptions of double-blind placebo, multicentre dose, independent placebo and multiple-masked surgical designs are retained separately.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Design labels do not verify all allocation, concealment, maintenance of masking or baseline balance. Original methods are unread.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Design labels do not verify all allocation, concealment, maintenance of masking or baseline balance. Original methods are unread." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Could background treatment, adherence or deviations affect attribution?", "needed": "Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes", "role": "Required", "role_reason": "Material on Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Immobilization, rehabilitation, analgesia, rescue drugs, adherence, group changes and analytical handling remain unverified. Contribution is not automatically assigned to the single ingredient. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Conservative treatment, surgery, placebo and standard-care comparisons remain separate.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Immobilization, rehabilitation, analgesia, rescue drugs, adherence, group changes and analytical handling remain unverified. Contribution is not automatically assigned to the single ingredient.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Immobilization, rehabilitation, analgesia, rescue drugs, adherence, group changes and analytical handling remain unverified. Contribution is not automatically assigned to the single ingredient." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are prespecified endpoints, registration and CAAE distinguished?", "needed": "Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval", "role": "Required", "role_reason": "Material on Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: CAAE is not promoted to prospective trial registration. Registration and plans are currently unread and access was not attempted. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Registration identifiers for 4 stored trial summaries could not be confirmed. S04’s official prespecified primary-endpoint hierarchy is also unverified; the original explanation that CAAE is an ethics-approval identifier is retained.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "CAAE is not promoted to prospective trial registration. Registration and plans are currently unread and access was not attempted.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "CAAE is not promoted to prospective trial registration. Registration and plans are currently unread and access was not attempted." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "How were multiple doses, times, subgroups and outcomes planned?", "needed": "Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes", "role": "Required", "role_reason": "Material on Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Prespecified multiplicity, times, subgroups, interactions and selective reporting remain unverified because plans are unread. This records needed materials; no new research was executed.", "current_reports": [ "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The200/500/1500 doses, S03 subgroup, S04’s12/24 weeks and CRPS/neuropathic pain remain separate.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Prespecified multiplicity, times, subgroups, interactions and selective reporting remain unverified because plans are unread.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Prespecified multiplicity, times, subgroups, interactions and selective reporting remain unverified because plans are unread." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "What effects do sparse events and intervals permit?", "needed": "Original RR/RD/95%CI, absence of events, denominators and important effects", "role": "Required", "role_reason": "Material on Original RR/RD/95%CI, absence of events, denominators and important effects is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original RR/RD/95%CI, absence of events, denominators and important effects must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original0 events do not establish guaranteed prevention; no new adjusted RR/CI or power is calculated. Important differences, exact denominators and plans remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Original early and dose intervals, the unverified surgical between-group CI and inclusion of no effect in the meta-analysis interval are retained together.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original0 events do not establish guaranteed prevention; no new adjusted RR/CI or power is calculated. Important differences, exact denominators and plans remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original0 events do not establish guaranteed prevention; no new adjusted RR/CI or power is calculated. Important differences, exact denominators and plans remain unverified." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Are conflicting effects and limits on independence retained together?", "needed": "Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences", "role": "Required", "role_reason": "Material on Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report counts are not confirmed as independent replication under the same conditions, and conflicting materials are not removed. S05 is not added as new direct participants. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Early positive findings, the 336-person opposing trial, the 2025 positive report and differences in surgery, diagnosis and dose are retained. S02, with the same investigators, is not newly credited as independent replication.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Report counts are not confirmed as independent replication under the same conditions, and conflicting materials are not removed. S05 is not added as new direct participants.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report counts are not confirmed as independent replication under the same conditions, and conflicting materials are not removed. S05 is not added as new direct participants." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "How far are funding, products, employees and conflicts verified?", "needed": "Study funding, product support, employment/patents and disclosures", "role": "Required", "role_reason": "Material on Study funding, product support, employment/patents and disclosures is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Study funding, product support, employment/patents and disclosures must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: No-support declarations are not extended to no product provision, no employee authors or no bias. The existing independence assessment remains a historical record. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Unverified funding for S01–S03 and S04’s declaration of no external funding/COI are retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "No-support declarations are not extended to no product provision, no employee authors or no bias. The existing independence assessment remains a historical record.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "No-support declarations are not extended to no product provision, no employee authors or no bias. The existing independence assessment remains a historical record." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "How far can long-term, dose and surgery findings be generalized?", "needed": "Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups", "role": "Required", "role_reason": "Material on Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Findings are not extended to always-better higher doses, every operation or fracture, or long-term prevention. Optimal dose and long-term prespecified subgroups remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Trial-specific dosing 50/90/60 days remains separate from follow-up of 1 year/90 days/24 weeks.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Findings are not extended to always-better higher doses, every operation or fracture, or long-term prevention. Optimal dose and long-term prespecified subgroups remain unverified.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Findings are not extended to always-better higher doses, every operation or fracture, or long-term prevention. Optimal dose and long-term prespecified subgroups remain unverified." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are pain and function kept separate from CRPS events?", "needed": "Diagnosed CRPS, DASH, pain/neuropathic pain boundaries", "role": "Required", "role_reason": "Material on Diagnosed CRPS, DASH, pain/neuropathic pain boundaries is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Diagnosed CRPS, DASH, pain/neuropathic pain boundaries must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Pain and function are not converted into diagnosed events or guaranteed long-term prevention. No separate quality-of-life or fracture-union benefit is created. This records needed materials; no new research was executed.", "current_reports": [ "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "S03’s DASH primary/CRPS secondary endpoints and S04’s CRPS/neuropathic pain remain separate. The original explanation that pain reduction differs from fewer diagnosed CRPS events is retained.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Pain and function are not converted into diagnosed events or guaranteed long-term prevention. No separate quality-of-life or fracture-union benefit is created.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Pain and function are not converted into diagnosed events or guaranteed long-term prevention. No separate quality-of-life or fracture-union benefit is created." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "How were harms from supplementation collected?", "needed": "Oral C adverse events, events/denominators, collection and discontinuation", "role": "Supplementary", "role_reason": "Material on Oral C adverse events, events/denominators, collection and discontinuation is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Oral C adverse events, events/denominators, collection and discontinuation must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Group-specific harms, collection, discontinuation, exposure and event denominators remain unverified. Reduced or unchanged CRPS does not establish safety. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Existing safety caution, gastrointestinal discomfort with high oral doses and limited trial-specific event counts are retained.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Group-specific harms, collection, discontinuation, exposure and event denominators remain unverified. Reduced or unchanged CRPS does not establish safety.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Group-specific harms, collection, discontinuation, exposure and event denominators remain unverified. Reduced or unchanged CRPS does not establish safety." }, { "item_id": "N33", "question_type": "Evidence condition", "question": "How do fracture/surgery, drugs and baseline susceptibility affect harm attribution?", "needed": "Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives", "role": "Supplementary", "role_reason": "Material on Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Specific interactions, harm causality, between-group risk, withdrawal, recovery and re-exposure remain unverified. No new incidence rate or causal judgment is created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Existing caution about oral use is linked to fracture and surgery conditions.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Specific interactions, harm causality, between-group risk, withdrawal, recovery and re-exposure remain unverified. No new incidence rate or causal judgment is created.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Specific interactions, harm causality, between-group risk, withdrawal, recovery and re-exposure remain unverified. No new incidence rate or causal judgment is created." }, { "item_id": "N34", "question_type": "Evidence condition", "question": "What is known about long-term, rare harms and vulnerable groups?", "needed": "Long-term/rare events and direct exposure in baseline disease or special populations", "role": "Supplementary", "role_reason": "Material on Long-term/rare events and direct exposure in baseline disease or special populations is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Long-term/rare events and direct exposure in baseline disease or special populations must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Limited event counts do not establish an absence of long-term or rare harms or safety for every vulnerable group. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Short-term supplementation/follow-up and the existing safety-caution scope are retained.", "condition_status": "Unverified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Limited event counts do not establish an absence of long-term or rare harms or safety for every vulnerable group.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Limited event counts do not establish an absence of long-term or rare harms or safety for every vulnerable group." }, { "item_id": "N35", "question_type": "Evidence condition", "question": "What do the existing C54, date and bilingual explanations mean?", "needed": "Existing C54, assessment values, 2026-09-07, bilingual explanations and change history", "role": "Required", "role_reason": "Material on Existing C54, assessment values, 2026-09-07, bilingual explanations and change history is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Existing C54, assessment values, 2026-09-07, bilingual explanations and change history must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Existing assessments and historical latest/verified wording are not inherited as current regrading, clinical review, a comprehensive literature search or completed reading of original material. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04", "S05" ], "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Existing Korean and English stored summary, trial records and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Existing C·54 points, assessment values, historical cross-check records and evidence date 2026-09-07 are retained. Existing corrections, additional subclaims and deliberation explanations are empty; this does not establish current reading of external original material.", "condition_status": "Partly verified", "status_reason": "The stored summary’s information is linked to its unverified scope. External verification and clinical content review remain incomplete; this does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Existing assessments and historical latest/verified wording are not inherited as current regrading, clinical review, a comprehensive literature search or completed reading of original material.", "uncertainty": "Gaps in study-specific populations, diagnosis, people/wrists, analysis populations, prespecified plans, support and harms remain. Conflicting results and sparse events are not converted into guaranteed prevention, an optimal dose, precise proof of no effect or overall safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Existing assessments and historical latest/verified wording are not inherited as current regrading, clinical review, a comprehensive literature search or completed reading of original material." } ], "reports": [ { "report_id": "S01", "title": "Zollinger et al. 1999 · Conservatively treated wrist fractures", "url": "https://pubmed.ncbi.nlm.nih.gov/10636366/", "report_type": "Double-blind placebo randomized trial; conservative treatment", "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "TF3021-01", "independent_replication": null, "observed_result": "4/54 versus 14/65 wrists. The paper-reported risk difference of 15 percentage points (95%CI2–26) is retained; rounding differences in raw proportions are not concealed through new calculation.", "result_level": "123 people and 127 wrists allocated→115 people and 119 wrists analyzed. C52 people/54 wrists and placebo 63 people/65 wrists remain separate. People and wrists are distinguished; detailed older RSD/CRPS diagnostic criteria remain unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID10636366 · DOI10.1016/S0140-6736(99)03059-7. The historical citation’s abstract-check record is retained. Only the stored summary was read here; external original material, registration and protocols are unread. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/10636366/" } ] }, { "report_id": "S02", "title": "Zollinger et al. 2007 · Multicentre dose report", "url": "https://pubmed.ncbi.nlm.nih.gov/17606778/", "report_type": "Double-blind multicentre dose randomized trial", "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "TF3021-02", "independent_replication": null, "observed_result": "Overall 8/328 versus 10/99, P=.002. The original dose results are retained: 200 mg 4/96, RR.41(95%CI.13–1.27); 500 mg 2/114, RR.17(.04–.77); 1500 mg 2/118, RR.17(.04–.75).", "result_level": "416 people/427 wrists; C317 people/328 wrists and placebo 99 people/99 wrists. Dose-specific wrist denominators and the shared placebo remain separate. Core investigators overlap with the early report; dose groups are not counted as separate independent trials.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID17606778 · DOI10.2106/JBJS.F.01147. Historical abstract checking and the shared-core-investigator note are retained without conversion into current reading of original material or new independent replication. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/17606778/" } ] }, { "report_id": "S03", "title": "Ekrol et al. 2014 · Independent placebo report", "url": "https://pubmed.ncbi.nlm.nih.gov/25187584/", "report_type": "Independent double-blind placebo randomized trial", "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "TF3021-03", "independent_replication": null, "observed_result": "The original finding of no demonstrated 1-year CRPS benefit is retained. Increased CRPS in the 6-week nondisplaced subgroup, P=.022, is not an overall prespecified primary harm result.", "result_level": "336 people were randomized; analysis and event denominators remain unverified. DASH function was primary and CRPS secondary. Exact effects, intervals, registration and analysis plans remain separately unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "PMID25187584 · DOI10.2106/JBJS.M.00268. Historical abstract checking and the primary/secondary distinction are retained. External original material and prespecified plans are currently unread; the opposing result is retained. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/25187584/" } ] }, { "report_id": "S04", "title": "de Azevedo Filho et al. 2025 · Surgical-patient report", "url": "https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0045-1810402", "report_type": "Double-/multiple-masked placebo surgical trial; prespecified endpoint hierarchy unverified", "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "TF3021-04", "independent_replication": null, "observed_result": "Budapest CRPS:12 weeks 0/58 versus 7/64, P=.014; 24 weeks 0/58 versus 8/64, P=.007. Between-group 95%CI is unreported/unverified.", "result_level": "Initial sample 137→122 completers(C58/placebo 64). Original randomized group denominators and missing-data/analysis handling remain unverified. The original declarations of no external funding/COI and the completer-analysis scope are retained.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "The original note identifies English PMID40860294, PMCIDPMC12377947, DOI10.1055/s-0045-1810402 and Portuguese PMID40860295, PMCIDPMC12377946, DOI10.1055/s-0045-1810403 as the same cohort. Historical HTML, methods, table and funding checks are not current reading. CAAE is an ethics-approval identifier; the specific table-denominator typo and any official correction remain unverified. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." } ], "links": [ { "label": "Official source", "url": "https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0045-1810402" } ] }, { "report_id": "S05", "title": "Evaniew et al. 2015 · Meta-analysis citation", "url": "https://pubmed.ncbi.nlm.nih.gov/26197022/", "report_type": "Citation-only meta-analysis; separate from direct trial summaries", "existence": "The information comes from stored trial summaries, a meta-analysis citation and Korean and English explanations. Detailed original material and current reading of external materials remain separately unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "SYN3021-05", "independent_replication": null, "observed_result": "The existing summary states that the pooled interval from 3 trials with 890 participants includes no effect and heterogeneity is substantial.", "result_level": "This is citation context for PMID26197022. Exact pooled values, intervals and included-trial mapping are unread and are not added as new direct trials or participants.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "This is the existing meta-analysis citation PMID26197022. Historical cross-check wording is retained, while original material, inclusion tables, extraction and analysis materials are unread here and are not double-counted with original trials. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "This is the existing meta-analysis citation PMID26197022. Historical cross-check wording is retained, while original material, inclusion tables, extraction and analysis materials are unread here and are not double-counted with original trials. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "This is the existing meta-analysis citation PMID26197022. Historical cross-check wording is retained, while original material, inclusion tables, extraction and analysis materials are unread here and are not double-counted with original trials. Dates for all material slots are the original record’s historical evidence date. 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Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "This is the existing meta-analysis citation PMID26197022. Historical cross-check wording is retained, while original material, inclusion tables, extraction and analysis materials are unread here and are not double-counted with original trials. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "This is the existing meta-analysis citation PMID26197022. Historical cross-check wording is retained, while original material, inclusion tables, extraction and analysis materials are unread here and are not double-counted with original trials. Dates for all material slots are the original record’s historical evidence date. Unread external slots retain the same historical date, which is not presented as current external reading." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26197022/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "The 1999 and 2007 reports share core investigators, but are not merged as identical participants or newly credited as independent replication. The 2025 English and Portuguese versions and 12-week and 24-week results are reports and time points from the same cohort. The meta-analysis’s 3 trials and 890 participants are not added to original trials; unique trial, participant and independent-replication totals remain unverified." }, "history": [ { "date": "2026-10-22", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "The public view and materials were prepared from the existing 35 items. No new clinical search, verification-state change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-22" }