{ "schema_version": "chamgap-public-criteria-1.0", "title": "Oral Vitamin C After Distal-Radius Fracture or Surgery—CRPS-I Results Remain Conflicting", "language": "en", "translation_date": "2026-10-22", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What is the original CRPS-I prevention question?", "needed": "Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up", "role": "Required", "role_reason": "Material on Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Distal-radius fracture/surgery, single oral C, diagnosed CRPS-I, comparison and follow-up must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: It is not extended to guaranteed prevention for every fracture, operation, pain score or other formulation. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "How does current reading differ from historical abstract or full-text checks?", "needed": "Stored JSON, historical HTML/abstract/cross-check records and current external materials", "role": "Required", "role_reason": "Material on Stored JSON, historical HTML/abstract/cross-check records and current external materials is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Stored JSON, historical HTML/abstract/cross-check records and current external materials must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External abstracts, full text, registration and plans are currently unread and access was not attempted. Historical reading is not inherited as current completion or clinical review. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What identifies the early 1999 report?", "needed": "Zollinger1999, PMID/DOI, conservative treatment and report/trial identity", "role": "Required", "role_reason": "Material on Zollinger1999, PMID/DOI, conservative treatment and report/trial identity is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Zollinger1999, PMID/DOI, conservative treatment and report/trial identity must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External original material, registration and related-report relationships were not checked here. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "What kind of replication is the 2007 dose report?", "needed": "Shared core investigators, multicentre dose trial and PMID/DOI", "role": "Required", "role_reason": "Material on Shared core investigators, multicentre dose trial and PMID/DOI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Shared core investigators, multicentre dose trial and PMID/DOI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Shared investigators establish neither identical participants nor a basis for promotion to new independent replication. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What identifies the opposing 2014 report and its endpoint?", "needed": "Ekrol2014, PMID/DOI and DASH primary/CRPS secondary", "role": "Required", "role_reason": "Material on Ekrol2014, PMID/DOI and DASH primary/CRPS secondary is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Ekrol2014, PMID/DOI and DASH primary/CRPS secondary must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: CRPS is not promoted to the overall prespecified primary endpoint. Original registration, analysis plans, events and denominators remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What identifies the 2025 surgical report?", "needed": "English report, bibliography, initial/completer samples, masking and Budapest criteria", "role": "Required", "role_reason": "Material on English report, bibliography, initial/completer samples, masking and Budapest criteria is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on English report, bibliography, initial/completer samples, masking and Budapest criteria must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Online2025-08-25/eCollection2025-06 is publication metadata, not proof of prospective registration. Original material is currently unread. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is the Portuguese version a separate independent trial?", "needed": "Language versions with different PMID/PMCID/DOI and the same-cohort relationship", "role": "Required", "role_reason": "Material on Language versions with different PMID/PMCID/DOI and the same-cohort relationship is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Language versions with different PMID/PMCID/DOI and the same-cohort relationship must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Different identifiers are not added as two trials or extra participants. The same-cohort relationship also remains limited to the stored narrative. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Where does the meta-analysis fit?", "needed": "Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap", "role": "Required", "role_reason": "Material on Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Citation-only review, included trials, exact pooling/heterogeneity and original-trial overlap must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The review is not counted as a new direct trial or 890 additional participants. Included trials, exact values and intervals are unread. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "How far do the 2021 positive-study and 2022 guideline mentions extend?", "needed": "Original narrative mentions, exact citations/trials and time scope", "role": "Required", "role_reason": "Material on Original narrative mentions, exact citations/trials and time scope is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original narrative mentions, exact citations/trials and time scope must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Exact citations for the 2021 trial and guideline are not individually linked. The 2022 document is not described as a definitive current guideline incorporating 2025. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Are conservative, older-fracture and adult surgical populations the same?", "needed": "Surgery status, age, fracture type/displacement, eligibility and baseline", "role": "Required", "role_reason": "Material on Surgery status, age, fracture type/displacement, eligibility and baseline is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Surgery status, age, fracture type/displacement, eligibility and baseline must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report-specific age, fracture, surgery, eligibility and mixture proportions remain unverified. Findings are not generalized to every operation or fracture. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "What are the purified nutrient and oral formulation?", "needed": "Single C, oral route, salts/excipients, feedstock and manufacture", "role": "Required", "role_reason": "Material on Single C, oral route, salts/excipients, feedstock and manufacture is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Single C, oral route, salts/excipients, feedstock and manufacture must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Study-specific tablet/capsule, salt, excipients and product identity remain unverified. They are not replaced by combinations, foods or intravenous infusion. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "How do dosing and follow-up differ between trials?", "needed": "200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up", "role": "Required", "role_reason": "Material on 200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 200/500/1500 mg for 50 days, 500 mg for 90 days, surgical 1 g for 60 days and follow-up must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Grouped dose details are not automatically assigned as each report’s full specification. No cumulative amount or duration is newly calculated without original material. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are people and wrists distinguished?", "needed": "S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists", "role": "Required", "role_reason": "Material on S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on S01:123 people/127 wrists→115 people/119 wrists; C52 people/54 wrists; placebo 63 people/65 wrists must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Wrist events are not converted into person events, and laterality, bilateral involvement, clustering, allocation or exclusion handling is not inferred. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What are the 1999 events and original risk difference?", "needed": "4/54 versus 14/65 wrists, reported risk difference and original interval", "role": "Required", "role_reason": "Material on 4/54 versus 14/65 wrists, reported risk difference and original interval is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 4/54 versus 14/65 wrists, reported risk difference and original interval must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Rounding differences in raw proportions are not concealed. Effect direction, models and person-level intervals are not newly inferred or recalculated. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "What are the 2007 people, wrist and dose denominators?", "needed": "416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists", "role": "Required", "role_reason": "Material on 416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 416 people/427 wrists; C317 people/328 wrists; placebo 99 people/99 wrists; dose-specific wrists must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Dose groups are not made into independent trials, and the shared placebo 99 wrists are not repeatedly summed. Clustering and analysis-unit correspondence remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "What are the overall and dose-specific 2007 effects?", "needed": "8/328 versus 10/99, P and 200/500/1500 RR/95%CI", "role": "Required", "role_reason": "Material on 8/328 versus 10/99, P and 200/500/1500 RR/95%CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 8/328 versus 10/99, P and 200/500/1500 RR/95%CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The inclusion of no effect in the 200 mg interval is retained. No conclusion that higher doses are always better, new pooling or new difference is created. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are older RSD/CRPS and Budapest definitions separated?", "needed": "Report-specific diagnosis, criteria, assessors and time window", "role": "Required", "role_reason": "Material on Report-specific diagnosis, criteria, assessors and time window is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Report-specific diagnosis, criteria, assessors and time window must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: They are not combined as the same event diagnosis or relabelled as Budapest criteria. Assessors, masking and misclassification remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "What is the scope of the 2014 analysis and 1-year null finding?", "needed": "336 randomized, CRPS secondary, 1 year, events/denominators/CI", "role": "Required", "role_reason": "Material on 336 randomized, CRPS secondary, 1 year, events/denominators/CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on 336 randomized, CRPS secondary, 1 year, events/denominators/CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Analysis and event denominators, effects/CI and DASH results are not filled in. A large allocation count is not converted into precise proof of no effect. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Is harm in the 6-week nondisplaced subgroup kept within scope?", "needed": "S03 time point, subgroup, prespecification and interaction", "role": "Supplementary", "role_reason": "Material on S03 time point, subgroup, prespecification and interaction is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on S03 time point, subgroup, prespecification and interaction must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: It is not extended to overall or 1-year harm or definitive causality. Events, denominators, prespecified subgroups, multiplicity and interactions remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What are the initial, completer and group denominators in 2025?", "needed": "Initial137→122 completers, C58/placebo 64, original allocation and losses", "role": "Required", "role_reason": "Material on Initial137→122 completers, C58/placebo 64, original allocation and losses is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Initial137→122 completers, C58/placebo 64, original allocation and losses must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: 137 is not converted into a confirmed randomized count. Reasons for loss, group allocation, missing data and ITT/PP remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are 2025 events at 12 and 24 weeks retained separately?", "needed": "Budapest events, the same completer group, each time point and P/CI", "role": "Required", "role_reason": "Material on Budapest events, the same completer group, each time point and P/CI is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Budapest events, the same completer group, each time point and P/CI must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Events and people at the two times are not summed, and an absence of events is not interpreted as 100% prevention. Between-group 95%CI is unreported/unverified. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "How far does the 2025 table-denominator typo record extend?", "needed": "Original table, typo location, correction/explanation and result denominator", "role": "Required", "role_reason": "Material on Original table, typo location, correction/explanation and result denominator is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original table, typo location, correction/explanation and result denominator must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: The specific table, cell, typo and any official correction are absent from the stored summary. The original table was not read or changed here, and no new denominator is inferred. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "What is the actual scope of trial design, allocation and masking?", "needed": "Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance", "role": "Required", "role_reason": "Material on Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Each RCT, sequence generation/concealment, assessment masking, surgery and baseline balance must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Design labels do not verify all allocation, concealment, maintenance of masking or baseline balance. Original methods are unread. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Could background treatment, adherence or deviations affect attribution?", "needed": "Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes", "role": "Required", "role_reason": "Material on Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Fracture care, surgery, immobilization/rehabilitation, analgesia, C adherence, rescue and changes must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Immobilization, rehabilitation, analgesia, rescue drugs, adherence, group changes and analytical handling remain unverified. Contribution is not automatically assigned to the single ingredient. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are prespecified endpoints, registration and CAAE distinguished?", "needed": "Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval", "role": "Required", "role_reason": "Material on Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Official registration/history, protocols/SAP, primary/secondary endpoints and ethics approval must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: CAAE is not promoted to prospective trial registration. Registration and plans are currently unread and access was not attempted. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "How were multiple doses, times, subgroups and outcomes planned?", "needed": "Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes", "role": "Required", "role_reason": "Material on Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Prespecified contrasts, primary/secondary endpoints, multiplicity and all outcomes must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Prespecified multiplicity, times, subgroups, interactions and selective reporting remain unverified because plans are unread. This records needed materials; no new research was executed." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "What effects do sparse events and intervals permit?", "needed": "Original RR/RD/95%CI, absence of events, denominators and important effects", "role": "Required", "role_reason": "Material on Original RR/RD/95%CI, absence of events, denominators and important effects is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Original RR/RD/95%CI, absence of events, denominators and important effects must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original0 events do not establish guaranteed prevention; no new adjusted RR/CI or power is calculated. Important differences, exact denominators and plans remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Are conflicting effects and limits on independence retained together?", "needed": "Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences", "role": "Required", "role_reason": "Material on Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Early positive findings, S03 opposing result, S04 positive result and formulation/diagnosis/surgery differences must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report counts are not confirmed as independent replication under the same conditions, and conflicting materials are not removed. S05 is not added as new direct participants. This records needed materials; no new research was executed." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "How far are funding, products, employees and conflicts verified?", "needed": "Study funding, product support, employment/patents and disclosures", "role": "Required", "role_reason": "Material on Study funding, product support, employment/patents and disclosures is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Study funding, product support, employment/patents and disclosures must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: No-support declarations are not extended to no product provision, no employee authors or no bias. The existing independence assessment remains a historical record. This records needed materials; no new research was executed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "How far can long-term, dose and surgery findings be generalized?", "needed": "Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups", "role": "Required", "role_reason": "Material on Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Direct doses, follow-up, surgical/conservative treatment and prespecified subgroups must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Findings are not extended to always-better higher doses, every operation or fracture, or long-term prevention. Optimal dose and long-term prespecified subgroups remain unverified. This records needed materials; no new research was executed." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are pain and function kept separate from CRPS events?", "needed": "Diagnosed CRPS, DASH, pain/neuropathic pain boundaries", "role": "Required", "role_reason": "Material on Diagnosed CRPS, DASH, pain/neuropathic pain boundaries is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Diagnosed CRPS, DASH, pain/neuropathic pain boundaries must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Pain and function are not converted into diagnosed events or guaranteed long-term prevention. No separate quality-of-life or fracture-union benefit is created. This records needed materials; no new research was executed." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "How were harms from supplementation collected?", "needed": "Oral C adverse events, events/denominators, collection and discontinuation", "role": "Supplementary", "role_reason": "Material on Oral C adverse events, events/denominators, collection and discontinuation is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Oral C adverse events, events/denominators, collection and discontinuation must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Group-specific harms, collection, discontinuation, exposure and event denominators remain unverified. Reduced or unchanged CRPS does not establish safety. This records needed materials; no new research was executed." }, { "item_id": "N33", "question_type": "Evidence condition", "question": "How do fracture/surgery, drugs and baseline susceptibility affect harm attribution?", "needed": "Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives", "role": "Supplementary", "role_reason": "Material on Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Concomitant treatment/analgesia, surgery/disease, kidney/stone/iron-overload risks, timing and alternatives must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Specific interactions, harm causality, between-group risk, withdrawal, recovery and re-exposure remain unverified. No new incidence rate or causal judgment is created. This records needed materials; no new research was executed." }, { "item_id": "N34", "question_type": "Evidence condition", "question": "What is known about long-term, rare harms and vulnerable groups?", "needed": "Long-term/rare events and direct exposure in baseline disease or special populations", "role": "Supplementary", "role_reason": "Material on Long-term/rare events and direct exposure in baseline disease or special populations is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Long-term/rare events and direct exposure in baseline disease or special populations must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Limited event counts do not establish an absence of long-term or rare harms or safety for every vulnerable group. This records needed materials; no new research was executed." }, { "item_id": "N35", "question_type": "Evidence condition", "question": "What do the existing C54, date and bilingual explanations mean?", "needed": "Existing C54, assessment values, 2026-09-07, bilingual explanations and change history", "role": "Required", "role_reason": "Material on Existing C54, assessment values, 2026-09-07, bilingual explanations and change history is needed to connect the selected prevention question to its population, formulation, dosing, comparison, diagnosis, time point, denominator, precision and harms.", "application_exception": "People and wrists, initial samples and completers, surgery and conservative treatment, and older versus Budapest diagnostic criteria remain separate. Work by the same investigators, language versions, time points and reviews are not counted as new independent replication or additional participants; no new effects, intervals, incidence rates, safety conclusions or individual dosing guidance are created.", "criterion": "Original records on Existing C54, assessment values, 2026-09-07, bilingual explanations and change history must link to the same population, diagnosis, comparison, time point and analysis unit, distinguishing recorded information from gaps.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, populations and diagnosis, denominators, precision and harms.", "condition_origin": "These evidence conditions apply to the existing question of oral vitamin C for CRPS-I prevention after distal-radius fracture or surgery. They link the reading scope and gaps of stored summaries without establishing new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Existing assessments and historical latest/verified wording are not inherited as current regrading, clinical review, a comprehensive literature search or completed reading of original material. This records needed materials; no new research was executed." } ] }