{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3018-main", "verdict_number": "3018", "title": "Oral vitamin C × endothelial FMD: results differ by population and acute versus sustained dosing", "view_version": "1.0", "view_created_date": "2026-10-21", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Coronary artery disease, hypertension and smoking cohorts are treated separately. Other vascular tests in diabetes or heart failure do not substitute for brachial FMD.", "intervention": "This concerns oral single-ingredient ascorbic acid supplements. Study-specific tablets, capsules, salts, excipients and manufacturing details remain unverified; foods, combinations and intravenous use are not automatically included.", "dose": "Acute 2 g, sustained 500 mg/day for 30 days or 1 g/day for 8 weeks are distinguished. Actual exposure, product, adherence and optimal dose remain unverified.", "comparator": "The treatment contrast is with placebo. Nonrandomized comparisons with healthy controls are not used as treatment effects; details of common medication and care remain unverified.", "endpoint": "Brachial FMD (%) is an ultrasound surrogate of vascular responsiveness. Absolute percentage points and relative percent are distinguished; findings are not extended to myocardial infarction or stroke prevention or anatomical recovery.", "duration": "The acute 2-hour response is distinguished from 30-day and 8-week results. The smoker report’s total 20-week schedule differs from 8 weeks of sustained vitamin C exposure.", "excluded_extensions": [ "Existing C50, caution, B/S/R0/I2/EX/B2/CX, disabled indicators and empty values are preserved. Historical independent-comparison wording does not establish completed clinical content review in this work.", "The existing +3.1 percentage points is a calculated simple 30-day change difference. It is not a published between-group 95% CI, relative improvement or cardiovascular risk reduction and was not recalculated here.", "The smoker report’s 8-week SD difference between body text 3.1 and abstract 3.2 remains unresolved. Neither value is arbitrarily selected, averaged or replaced.", "Acute and sustained results or different populations are not combined as exact replication. BP or glycaemic reports, shared cohorts, mixed reviews and other vascular tests are not added as independent FMD confirmation.", "Existing caution concerning gastrointestinal effects of high oral doses, stone risk, kidney disease and iron overload is retained. Unread material does not establish absence of harm; no individual dosing guidance or new incidence is created." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which FMD question is addressed?", "needed": "Oral single-ingredient C and brachial FMD in adults at cardiovascular risk", "role": "Required", "role_reason": "Material on Oral single-ingredient C and brachial FMD in adults at cardiovascular risk is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Oral single-ingredient C and brachial FMD in adults at cardiovascular risk must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original population, oral product, placebo and brachial FMD endpoint/time tables are needed. Clinical events or artery cleansing are not added. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The outcome is improved brachial FMD. This ultrasound vascular-response surrogate does not measure myocardial infarction, stroke or anatomical recovery.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original population, oral product, placebo and brachial FMD endpoint/time tables are needed. Clinical events or artery cleansing are not added.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original population, oral product, placebo and brachial FMD endpoint/time tables are needed. Clinical events or artery cleansing are not added." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Are oral single-ingredient C and intravenous or combined products distinguished?", "needed": "Ascorbic acid product, salt, excipients and route", "role": "Required", "role_reason": "Material on Ascorbic acid product, salt, excipients and route is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Ascorbic acid product, salt, excipients and route must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original product, manufacturing, salt, excipient, exposure/adherence and route-specific eligibility tables are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The formulation is single ingredient; study-specific products, salts and excipients remain unverified. Intravenous use, foods and combinations are not merged with oral FMD.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original product, manufacturing, salt, excipient, exposure/adherence and route-specific eligibility tables are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original product, manufacturing, salt, excipient, exposure/adherence and route-specific eligibility tables are needed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Are acute 2 g, 500 mg/day and 1 g/day kept separate?", "needed": "Acute and sustained doses and report-specific products/exposure", "role": "Required", "role_reason": "Material on Acute and sustained doses and report-specific products/exposure is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Acute and sustained doses and report-specific products/exposure must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Report-specific dosing, time points, actual exposure, products and adherence need to be linked. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Doses are acute 2 g, sustained 500 mg/day for 30 days or 1 g/day for 8 weeks. Original values are retained without deriving active amounts, equivalent doses or recommendations.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Report-specific dosing, time points, actual exposure, products and adherence need to be linked.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific dosing, time points, actual exposure, products and adherence need to be linked." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are 2 hours, 30 days, 8 weeks and the total schedule distinguished?", "needed": "Acute/sustained time points, crossover periods and total schedule", "role": "Required", "role_reason": "Material on Acute/sustained time points, crossover periods and total schedule is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Acute/sustained time points, crossover periods and total schedule must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original dosing, washout/placebo periods, assessment, total schedule and post-stopping course are needed. The 20 weeks is not converted into sustained C efficacy. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The duration separates acute 2 hours from 30 days and 8 weeks. R03 records a total 20-week schedule, distinct from 8 weeks of C exposure.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original dosing, washout/placebo periods, assessment, total schedule and post-stopping course are needed. The 20 weeks is not converted into sustained C efficacy.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original dosing, washout/placebo periods, assessment, total schedule and post-stopping course are needed. The 20 weeks is not converted into sustained C efficacy." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Are CAD, hypertension, smokers and other vascular tests separated?", "needed": "Disease-specific diagnosis/baseline and brachial FMD versus other tests", "role": "Required", "role_reason": "Material on Disease-specific diagnosis/baseline and brachial FMD versus other tests is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Disease-specific diagnosis/baseline and brachial FMD versus other tests must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original diagnosis, baseline, medication, test/site, formulation and time-specific inclusion tables are needed. A mixed mean is not used as a single-population value. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "CAD, hypertension and smoking cohorts are treated separately; other vascular tests in diabetes or heart failure do not substitute for FMD.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original diagnosis, baseline, medication, test/site, formulation and time-specific inclusion tables are needed. A mixed mean is not used as a single-population value.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original diagnosis, baseline, medication, test/site, formulation and time-specific inclusion tables are needed. A mixed mean is not used as a single-population value." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are placebo and nonrandomized healthy comparisons distinguished?", "needed": "Treatment versus placebo and nonrandomized healthy-control conditions", "role": "Required", "role_reason": "Material on Treatment versus placebo and nonrandomized healthy-control conditions is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Treatment versus placebo and nonrandomized healthy-control conditions must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original group/condition, allocation, common care and measurement-time tables are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The comparator is placebo; nonrandomized healthy comparisons are excluded from the treatment effect. Healthy-group differences are not converted into C effects.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original group/condition, allocation, common care and measurement-time tables are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original group/condition, allocation, common care and measurement-time tables are needed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What baseline medication, smoking and diet/care rules applied?", "needed": "Group-specific maintained/changed treatment, smoking and additional interventions", "role": "Required", "role_reason": "Material on Group-specific maintained/changed treatment, smoking and additional interventions is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Group-specific maintained/changed treatment, smoking and additional interventions must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original medication, smoking/lifestyle care, premeasurement rules, changes/adherence and rescue medication are needed. An isolated C effect is not established. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Baseline differences remain, but detailed medication, smoking/diet and common-care rules are not preserved.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original medication, smoking/lifestyle care, premeasurement rules, changes/adherence and rescue medication are needed. An isolated C effect is not established.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original medication, smoking/lifestyle care, premeasurement rules, changes/adherence and rescue medication are needed. An isolated C effect is not established." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What are the CAD sample of 46 and group-specific analysis denominators?", "needed": "R01 allocation, analysis, completion and time-specific FMD denominators", "role": "Required", "role_reason": "Material on R01 allocation, analysis, completion and time-specific FMD denominators is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on R01 allocation, analysis, completion and time-specific FMD denominators must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original flow, group allocation/completion, imaging/measurement missingness and denominators are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 records 46 participants with CAD; group-specific analysis denominators are unverified. Acute/30-day counts and group allocation/attrition are not newly created.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original flow, group allocation/completion, imaging/measurement missingness and denominators are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original flow, group allocation/completion, imaging/measurement missingness and denominators are needed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Are CAD baseline, acute and 30-day values preserved?", "needed": "R01 time- and group-specific FMD% and original ±", "role": "Required", "role_reason": "Material on R01 time- and group-specific FMD% and original ± is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on R01 time- and group-specific FMD% and original ± must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original groups/time points, dispersion, baseline adjustment, denominators and complete results are needed. No new difference, CI or relative improvement is calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 records C 6.6±3.5→10.1±5.2 (acute)→9.0±3.7 (30 days)%; placebo 8.6±4.7→7.8±4.4→7.9±4.5%. The meaning of ± is unverified.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original groups/time points, dispersion, baseline adjustment, denominators and complete results are needed. No new difference, CI or relative improvement is calculated.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original groups/time points, dispersion, baseline adjustment, denominators and complete results are needed. No new difference, CI or relative improvement is calculated." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Is repeated-measures ANOVA distinguished from each time-specific contrast?", "needed": "Original repeated test, interaction and time-specific between-group CIs/P values", "role": "Required", "role_reason": "Material on Original repeated test, interaction and time-specific between-group CIs/P values is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Original repeated test, interaction and time-specific between-group CIs/P values must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original model, plan, time-specific estimates/CIs and multiplicity information are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 repeated-measures ANOVA P=.005 is retained. It is not copied into separate acute/30-day significant between-group contrasts.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original model, plan, time-specific estimates/CIs and multiplicity information are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original model, plan, time-specific estimates/CIs and multiplicity information are needed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Is the existing +3.1 percentage-point calculation distinguished from relative percent and CIs?", "needed": "Simple 30-day change difference versus original adjusted effect/interval and units", "role": "Required", "role_reason": "Material on Simple 30-day change difference versus original adjusted effect/interval and units is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Simple 30-day change difference versus original adjusted effect/interval and units must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original between-group estimates, variance, CIs, denominators, model and units are needed. The prior value is not converted into relative percent or clinical risk reduction. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing +3.1 percentage points is a prior simple change-difference calculation, not a between-group 95% CI. Percentage points differ from relative percent improvement. This is not a new calculation or certification of a precise effect.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original between-group estimates, variance, CIs, denominators, model and units are needed. The prior value is not converted into relative percent or clinical risk reduction.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original between-group estimates, variance, CIs, denominators, model and units are needed. The prior value is not converted into relative percent or clinical risk reduction." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Are the hypertension sample of 39 and acute/1-month null result retained?", "needed": "R02 direct FMD result, group denominators and CIs", "role": "Required", "role_reason": "Material on R02 direct FMD result, group denominators and CIs is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on R02 direct FMD result, group denominators and CIs must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original group flow, FMD time points/denominators, estimates/CIs, variance and model tables are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R02 records 39 participants, with acute/1-month FMD benefit not demonstrated and exact net difference/CI unverified. CAD values are not copied and this is not promoted into a precise 0 effect or equivalence.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original group flow, FMD time points/denominators, estimates/CIs, variance and model tables are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original group flow, FMD time points/denominators, estimates/CIs, variance and model tables are needed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Is the B1-related cohort excluded from new independent replication counts?", "needed": "Sample linkage between hypertension FMD and related BP reports", "role": "Required", "role_reason": "Material on Sample linkage between hypertension FMD and related BP reports is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Sample linkage between hypertension FMD and related BP reports must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original institutions/periods, registration, samples, groups/denominators and report links are needed. Other verdict files or participants are not added here. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R02 endpoint/citation records a B1-related cohort and prohibits double counting. A separate BP-endpoint paper is not counted as a new independent FMD trial.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original institutions/periods, registration, samples, groups/denominators and report links are needed. Other verdict files or participants are not added here.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original institutions/periods, registration, samples, groups/denominators and report links are needed. Other verdict files or participants are not added here." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "What are the smoker sample of 20 and acute image exclusion?", "needed": "R03 crossover/period-specific allocation, analysis and image-quality denominators", "role": "Required", "role_reason": "Material on R03 crossover/period-specific allocation, analysis and image-quality denominators is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on R03 crossover/period-specific allocation, analysis and image-quality denominators must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original sequence/period flow, image exclusions, acute/8-week denominators and baseline/missingness rules are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R03 records 20 healthy smokers and 1 acute image excluded for quality. An acute sample size is not newly derived and all 20 are not assumed included in every image analysis.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original sequence/period flow, image exclusions, acute/8-week denominators and baseline/missingness rules are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original sequence/period flow, image exclusions, acute/8-week denominators and baseline/missingness rules are needed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Is acute FMD in smokers separated from sustained results?", "needed": "R03 original acute mean±SD, P value and contrast", "role": "Required", "role_reason": "Material on R03 original acute mean±SD, P value and contrast is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on R03 original acute mean±SD, P value and contrast must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original acute groups/periods, time points, adjustment/contrasts, denominators/intervals and dispersion tables are needed. No new difference is calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R03 mean±SD is 2.8±2.0→6.3±2.8%, acute P<.001. This is not copied as an 8-week or clinical-event effect/P value.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original acute groups/periods, time points, adjustment/contrasts, denominators/intervals and dispersion tables are needed. No new difference is calculated.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original acute groups/periods, time points, adjustment/contrasts, denominators/intervals and dispersion tables are needed. No new difference is calculated." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are the smoker 8-week placebo contrast and SD discrepancy retained?", "needed": "Approximately 3.9% at 8 weeks, P=.26 and body/abstract SD", "role": "Required", "role_reason": "Material on Approximately 3.9% at 8 weeks, P=.26 and body/abstract SD is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Approximately 3.9% at 8 weeks, P=.26 and body/abstract SD must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original body/tables/abstract, groups/time points, denominators, corrections/dispersion and CIs are needed. The unresolved record is retained without new external comparison or numerical calculation. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R03 records approximately 3.9% at 8 weeks, versus placebo P=.26, with 8-week SD differing between body text 3.1 and abstract 3.2. An SD is not selected, corrected or averaged, and the acute positive finding does not replace it.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original body/tables/abstract, groups/time points, denominators, corrections/dispersion and CIs are needed. The unresolved record is retained without new external comparison or numerical calculation.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original body/tables/abstract, groups/time points, denominators, corrections/dispersion and CIs are needed. The unresolved record is retained without new external comparison or numerical calculation." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are acute, sustained and different populations kept apart as replication?", "needed": "Direct replication under the same formulation, diagnosis and duration, and heterogeneity", "role": "Required", "role_reason": "Material on Direct replication under the same formulation, diagnosis and duration, and heterogeneity is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Direct replication under the same formulation, diagnosis and duration, and heterogeneity must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original disease, baseline, formulation, duration, estimand and effect/denominator links are needed. No new pooled effect or independent replication count is created. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing counterview retains the possibility of CAD benefit at 30 days, different hypertension/smoker conditions and coexistence of acute benefit with sustained uncertainty.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original disease, baseline, formulation, duration, estimand and effect/denominator links are needed. No new pooled effect or independent replication count is created.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original disease, baseline, formulation, duration, estimand and effect/denominator links are needed. No new pooled effect or independent replication count is created." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Is the 2014 review of 44 RCTs kept distinct from 44 oral brachial FMD trials?", "needed": "Ashor review routes, vascular tests, populations and included trials", "role": "Required", "role_reason": "Material on Ashor review routes, vascular tests, populations and included trials is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Ashor review routes, vascular tests, populations and included trials must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original oral/intravenous, test/site, disease and duration-specific eligibility, extraction and shared-trial tables are needed. The review is not added as a new primary trial or summed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Bibliography-only R04 retains endothelial-function signals and population mixing across 44 RCTs. This is not a verified count of oral single-ingredient brachial FMD trials.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original oral/intravenous, test/site, disease and duration-specific eligibility, extraction and shared-trial tables are needed. The review is not added as a new primary trial or summed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original oral/intravenous, test/site, disease and duration-specific eligibility, extraction and shared-trial tables are needed. The review is not added as a new primary trial or summed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Is the sustained oral null-result diabetes citation kept distinct from FMD?", "needed": "Darko report test/site, exposure, comparator and denominator", "role": "Required", "role_reason": "Material on Darko report test/site, exposure, comparator and denominator is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Darko report test/site, exposure, comparator and denominator must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original vascular test, site, method, exposure and outcome/denominator tables are needed. Direct versus boundary relevance to FMD remains awaiting content review. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Bibliography-only R05 retains a null result with sustained oral treatment in T2D. The question scope does not substitute other vascular tests in diabetes/heart failure for FMD. Specific brachial FMD values or denominators are not invented.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original vascular test, site, method, exposure and outcome/denominator tables are needed. Direct versus boundary relevance to FMD remains awaiting content review.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original vascular test, site, method, exposure and outcome/denominator tables are needed. Direct versus boundary relevance to FMD remains awaiting content review." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are FMD measurement, units and endothelial dependence known?", "needed": "Brachial ultrasound, baseline diameter, dilation percentage and assessment/time rules", "role": "Required", "role_reason": "Material on Brachial ultrasound, baseline diameter, dilation percentage and assessment/time rules is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Brachial ultrasound, baseline diameter, dilation percentage and assessment/time rules must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original ultrasound/occlusion, premeasurement conditions, assessors/reliability, baseline diameter, time points and analysis plans are needed. No new unit conversion or mechanism is established. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The primary endpoint is brachial FMD%, distinguishing percentage points from relative percent. It does not substitute for other vascular tests or anatomical recovery.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original ultrasound/occlusion, premeasurement conditions, assessors/reliability, baseline diameter, time points and analysis plans are needed. No new unit conversion or mechanism is established.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original ultrasound/occlusion, premeasurement conditions, assessors/reliability, baseline diameter, time points and analysis plans are needed. No new unit conversion or mechanism is established." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What allocation, blinding and crossover methods applied?", "needed": "Original CAD/hypertension parallel and smoker crossover methods", "role": "Required", "role_reason": "Material on Original CAD/hypertension parallel and smoker crossover methods is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Original CAD/hypertension parallel and smoker crossover methods must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original sequence, concealment, assessors/blinding, washout/period effects, crossover sets and methods are needed. No formal RoB2/GRADE is produced. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 double-blind placebo RCT, R02 hypertension placebo RCT report and R03 double-blind placebo crossover are retained separately. All detailed methodological adequacy remains unverified here.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original sequence, concealment, assessors/blinding, washout/period effects, crossover sets and methods are needed. No formal RoB2/GRADE is produced.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original sequence, concealment, assessors/blinding, washout/period effects, crossover sets and methods are needed. No formal RoB2/GRADE is produced." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Were prior endpoints, all time points and selective reporting checked?", "needed": "Acute/sustained FMD hierarchy, registration/plans and multiplicity", "role": "Required", "role_reason": "Material on Acute/sustained FMD hierarchy, registration/plans and multiplicity is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Acute/sustained FMD hierarchy, registration/plans and multiplicity must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original registration, protocol/SAP, all time points/endpoints, corrections and plan changes are needed. Preregistration or complete compliance is not newly assigned. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01/R03 record unverified prior endpoint hierarchy and unknown registration numbers. A positive repeated test does not mean significance at every time point.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original registration, protocol/SAP, all time points/endpoints, corrections and plan changes are needed. Preregistration or complete compliance is not newly assigned.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original registration, protocol/SAP, all time points/endpoints, corrections and plan changes are needed. Preregistration or complete compliance is not newly assigned." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "What is the impact of missingness, image exclusions and analysis sets?", "needed": "Group/period flow, measurement missingness, exclusions and handling", "role": "Required", "role_reason": "Material on Group/period flow, measurement missingness, exclusions and handling is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Group/period flow, measurement missingness, exclusions and handling must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original flow, image/measurement missingness, attrition/exclusion reasons, ITT/crossover completers, handling and sensitivity material are needed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 unknown group sample sizes are distinguished from R03 acute image-quality exclusion. Detailed missingness and analysis sets remain unverified.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original flow, image/measurement missingness, attrition/exclusion reasons, ITT/crossover completers, handling and sensitivity material are needed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original flow, image/measurement missingness, attrition/exclusion reasons, ITT/crossover completers, handling and sensitivity material are needed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are BP, glycaemia and myocardial infarction/stroke excluded from FMD confirmation?", "needed": "Direct material on other indications/endpoints and clinical events", "role": "Supplementary", "role_reason": "Material on Direct material on other indications/endpoints and clinical events is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Direct material on other indications/endpoints and clinical events must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Direct research on each clinical or other endpoint is separately needed. Other pages/grades and reports from the same sample are not newly added. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The existing explanation does not transfer BP or glycaemia into FMD confirmation and states that FMD does not establish MI/stroke prevention.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Direct research on each clinical or other endpoint is separately needed. Other pages/grades and reports from the same sample are not newly added.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct research on each clinical or other endpoint is separately needed. Other pages/grades and reports from the same sample are not newly added." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are the four company-involvement pathways preserved by report?", "needed": "Funding, product/placebo support, employee authors and COI", "role": "Required", "role_reason": "Material on Funding, product/placebo support, employee authors and COI is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Funding, product/placebo support, employee authors and COI must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original support/fellowships, product provision, affiliations and COI are needed. Overall I2 and specific I1 do not overwrite each other or establish absence of company involvement. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "R01 public-support indexing/manufacturer role unverified, R02 NIH/NHMRC/AHA and an individual ACC/Merck fellowship, and R03 public/university plus Blackmores funding/product/placebo support I1 are retained separately.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original support/fellowships, product provision, affiliations and COI are needed. Overall I2 and specific I1 do not overwrite each other or establish absence of company involvement.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original support/fellowships, product provision, affiliations and COI are needed. Overall I2 and specific I1 do not overwrite each other or establish absence of company involvement." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Are 5 reports, shared cohorts and unique trials/participants distinguished?", "needed": "3 primary-trial reports, 2 review/diabetes citations and overlap/sharing", "role": "Required", "role_reason": "Material on 3 primary-trial reports, 2 review/diabetes citations and overlap/sharing is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on 3 primary-trial reports, 2 review/diabetes citations and overlap/sharing must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original report/trial map, registration, institutions/periods, participants, products/teams and inclusion tables are needed. No new totals or independence is established. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The 3 trial summaries and 5 citations are different material units; hypertension B1 sharing, review inclusion and diabetes-test directness remain separately unverified. Unique trial/participant totals are null.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original report/trial map, registration, institutions/periods, participants, products/teams and inclusion tables are needed. No new totals or independence is established.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original report/trial map, registration, institutions/periods, participants, products/teams and inclusion tables are needed. No new totals or independence is established." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Are harm collection, events and discontinuation known?", "needed": "Gastrointestinal effects, collection, events/discontinuation and severity", "role": "Supplementary", "role_reason": "Material on Gastrointestinal effects, collection, events/discontinuation and severity is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Gastrointestinal effects, collection, events/discontinuation and severity must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Original harm methods, events/discontinuation, missingness and comparator data are needed. Unread material is not treated as no harm. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The safety account retains high-dose oral C gastrointestinal caution and limited event counts. Original event tables, collection methods and causality are not newly established.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Original harm methods, events/discontinuation, missingness and comparator data are needed. Unread material is not treated as no harm.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original harm methods, events/discontinuation, missingness and comparator data are needed. Unread material is not treated as no harm." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "What are harm denominators, acute/sustained exposure and comparators?", "needed": "Safety sets, actual treatment, period/group events and crossover exposure", "role": "Supplementary", "role_reason": "Material on Safety sets, actual treatment, period/group events and crossover exposure is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Safety sets, actual treatment, period/group events and crossover exposure must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Group/period safety denominators, exposure/discontinuation, events, comparators and same-participant links are needed. Incidence is not calculated. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The 46, 39, 20 and image exclusions do not certify safety denominators. Acute/30-day/8-week/total schedules are not combined as identical harm exposure.", "condition_status": "Unverified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Group/period safety denominators, exposure/discontinuation, events, comparators and same-participant links are needed. Incidence is not calculated.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Group/period safety denominators, exposure/discontinuation, events, comparators and same-participant links are needed. Incidence is not calculated." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "What is known about coadministration, kidney/stone risk, iron overload and long-term harms?", "needed": "Vulnerable populations, coadministration/alternative causes and independent/rare/long-term harms", "role": "Supplementary", "role_reason": "Material on Vulnerable populations, coadministration/alternative causes and independent/rare/long-term harms is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Vulnerable populations, coadministration/alternative causes and independent/rare/long-term harms must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: Coadministration/baseline, event timing/course, independent reports, vulnerable groups, longer exposure and denominators are needed. No new harm search or judgment is performed. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "The product account retains caution for stone predisposition, kidney disease and iron overload. An FMD physiological signal does not certify long-term safety or drug-specific interactions.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "Coadministration/baseline, event timing/course, independent reports, vulnerable groups, longer exposure and denominators are needed. No new harm search or judgment is performed.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Coadministration/baseline, event timing/course, independent reports, vulnerable groups, longer exposure and denominators are needed. No new harm search or judgment is performed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Are past abstract/index/body checks distinguished from current unread material?", "needed": "Historical access wording, stored summary and external abstracts/full text/registration/plans", "role": "Required", "role_reason": "Material on Historical access wording, stored summary and external abstracts/full text/registration/plans is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Historical access wording, stored summary and external abstracts/full text/registration/plans must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: External unread status is retained until acquisition and content review. Historical verification or URLs are not promoted into current reading or completed QA. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Citations historically record abstract checks, indexed body/tables/methods/funding and independent comparison. This work reads the stored summary; external material remains unread.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "External unread status is retained until acquisition and content review. Historical verification or URLs are not promoted into current reading or completed QA.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External unread status is retained until acquisition and content review. Historical verification or URLs are not promoted into current reading or completed QA." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are Korean/English text, empty corrections and prior calculation/discrepancy preserved?", "needed": "Complete originals, empty correction/subclaim arrays and calculation/SD difference", "role": "Supplementary", "role_reason": "Material on Complete originals, empty correction/subclaim arrays and calculation/SD difference is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Complete originals, empty correction/subclaim arrays and calculation/SD difference must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: After content review, new material, corrections or verdict changes are recorded as separate events. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "Korean/English originals, empty correction/subclaim records, the prior +3.1 percentage-point calculation and 8-week SD 3.1/3.2 record are preserved. No new correction, external comparison or calculation is made.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "After content review, new material, corrections or verdict changes are recorded as separate events.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "After content review, new material, corrections or verdict changes are recorded as separate events." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "Are original C50, EX/CX, axes and evidence date distinct from production?", "needed": "Original C50, caution, assessment axes and evidence date", "role": "Required", "role_reason": "Material on Original C50, caution, assessment axes and evidence date is needed to connect oral single-ingredient treatment, populations, comparators, vascular tests, time points, denominators, precision and harms.", "application_exception": "Existing C50, caution, assessment axes and empty values are retained. Oral and intravenous use, single and combined ingredients, acute and sustained outcomes, populations and vascular tests, and percentage points and relative percent are distinguished. No new effects, CIs, denominators, incidence, unique totals or recommended doses are calculated.", "criterion": "Original records on Original C50, caution, assessment axes and evidence date must link to the same product, population, comparator, test, time point and denominator, distinguishing acute from sustained outcomes and direct findings from supporting or boundary material.", "basis": "Existing principles distinguish questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms.", "condition_origin": "These evidence conditions concern the existing question of oral single-ingredient vitamin C and brachial FMD in adults at cardiovascular risk. They do not establish new preregistration, official assessment or independent clinical validation.", "proposed_research": "Material needed: New material, condition revisions and verdict changes are separate events after content review. The original date is not used as a current search or external reading date. This records needed materials; no new research was executed.", "current_reports": [ "R01", "R02", "R03", "R04", "R05" ], "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread", "observation": "C/50/caution, EX/CX, original assessment axes and the existing evidence date 2026-09-07 are retained. The original account of 1 strength is not a new quality score or efficacy certification.", "condition_status": "Partly verified", "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.", "missingness": "New material, condition revisions and verdict changes are separate events after content review. The original date is not used as a current search or external reading date.", "uncertainty": "Group- and time-specific denominators, the meaning of ±, between-group CIs, prespecified hierarchy, shared samples, review inclusion, test methods and long-term or harm details remain unverified. Existing calculations and SD differences are not converted into new verification, calculation or completed review.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "New material, condition revisions and verdict changes are separate events after content review. The original date is not used as a current search or external reading date." } ], "reports": [ { "report_id": "R01", "title": "Gokce et al. 1999", "url": "https://pubmed.ncbi.nlm.nih.gov/10385496/", "report_type": "Stored summary of a double-blind placebo-controlled CAD trial", "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing stored review summary read; external material unread", "study_family": "Distinguish 3 CAD, hypertension and smoker reports from 2 mixed endothelial-review/diabetes-boundary citations; acute/sustained exposure, oral/intravenous route, test methods, B1 sharing, denominators/CIs, SD discrepancy and independent replication remain unverified", "independent_replication": "Reports are distinguished from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "C 6.6±3.5→10.1±5.2 (acute)→9.0±3.7 (30 days)%; placebo 8.6±4.7→7.8±4.4→7.9±4.5%. Repeated-measures ANOVA P=.005. The existing simple 30-day change difference +3.1 percentage points is a calculation, not a between-group 95% CI. The meaning of ± remains unverified.", "result_level": "This concerns 46 adults with CAD; group- and time-specific analysis denominators remain unverified. The repeated-measures P value is not copied into every time-specific between-group comparison.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:55:15.444738+09:00", "qualification": "PMID10385496 · DOI10.1161/01.CIR.99.25.3234 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10385496 · DOI10.1161/01.CIR.99.25.3234 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10385496 · DOI10.1161/01.CIR.99.25.3234 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10385496 · DOI10.1161/01.CIR.99.25.3234 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10385496 · DOI10.1161/01.CIR.99.25.3234 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/10385496/" } ] }, { "report_id": "R02", "title": "Duffy et al. 2001", "url": "https://journals.physiology.org/doi/abs/10.1152/ajpheart.2001.280.2.H528", "report_type": "Stored FMD report summary from a hypertension placebo trial", "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing stored review summary read; external material unread", "study_family": "Distinguish 3 CAD, hypertension and smoker reports from 2 mixed endothelial-review/diabetes-boundary citations; acute/sustained exposure, oral/intravenous route, test methods, B1 sharing, denominators/CIs, SD discrepancy and independent replication remain unverified", "independent_replication": "Reports are distinguished from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "In 39 participants, acute and 1-month FMD benefit was not demonstrated; the exact net difference and 95% CI remain unverified.", "result_level": "The cohort is related to the B1 BP report. It is not added as new independent FMD replication or filled with CAD values.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:55:15.444738+09:00", "qualification": "PMID11158948 · DOI10.1152/ajpheart.2001.280.2.H528 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID11158948 · DOI10.1152/ajpheart.2001.280.2.H528 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID11158948 · DOI10.1152/ajpheart.2001.280.2.H528 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID11158948 · DOI10.1152/ajpheart.2001.280.2.H528 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID11158948 · DOI10.1152/ajpheart.2001.280.2.H528 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." } ], "links": [ { "label": "Official source", "url": "https://journals.physiology.org/doi/abs/10.1152/ajpheart.2001.280.2.H528" } ] }, { "report_id": "R03", "title": "Raitakari et al. 2000", "url": "https://www.jacc.org/doi/10.1016/S0735-1097%2800%2900576-3", "report_type": "Stored summary of a double-blind placebo crossover trial in smokers", "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing stored review summary read; external material unread", "study_family": "Distinguish 3 CAD, hypertension and smoker reports from 2 mixed endothelial-review/diabetes-boundary citations; acute/sustained exposure, oral/intravenous route, test methods, B1 sharing, denominators/CIs, SD discrepancy and independent replication remain unverified", "independent_replication": "Reports are distinguished from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "Mean±SD 2.8±2.0→6.3±2.8%, acute P<.001. At 8 weeks approximately 3.9%, versus placebo P=.26. The 8-week SD differs: body text 3.1 and abstract 3.2.", "result_level": "The record retains 20 healthy smokers and 1 acute image excluded for quality. The total 20-week schedule is distinguished from 8 weeks of C exposure; Blackmores funding and product/placebo support is retained as I1.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:55:15.444738+09:00", "qualification": "PMID10807468 · DOI10.1016/S0735-1097(00)00576-3 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10807468 · DOI10.1016/S0735-1097(00)00576-3 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10807468 · DOI10.1016/S0735-1097(00)00576-3 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10807468 · DOI10.1016/S0735-1097(00)00576-3 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID10807468 · DOI10.1016/S0735-1097(00)00576-3 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." } ], "links": [ { "label": "Official source", "url": "https://www.jacc.org/doi/10.1016/S0735-1097%2800%2900576-3" } ] }, { "report_id": "R04", "title": "Ashor et al. 2014", "url": "https://pubmed.ncbi.nlm.nih.gov/24792921/", "report_type": "Bibliography and summary of a mixed endothelial-function review", "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing stored review summary read; external material unread", "study_family": "Distinguish 3 CAD, hypertension and smoker reports from 2 mixed endothelial-review/diabetes-boundary citations; acute/sustained exposure, oral/intravenous route, test methods, B1 sharing, denominators/CIs, SD discrepancy and independent replication remain unverified", "independent_replication": "Reports are distinguished from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "The existing citation records endothelial-function signals and mixed populations across 44 RCTs.", "result_level": "This does not mean all 44 were oral single-ingredient brachial FMD trials. Routes, tests, populations, durations and inclusion tables remain unverified; the review is not added as a new primary trial.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:55:15.444738+09:00", "qualification": "PMID24792921 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID24792921 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID24792921 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID24792921 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID24792921 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/24792921/" } ] }, { "report_id": "R05", "title": "Darko et al. 2002", "url": "https://pubmed.ncbi.nlm.nih.gov/12241530/", "report_type": "Boundary bibliography and summary concerning vascular testing in diabetes", "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.", "acquired_read": "Existing stored review summary read; external material unread", "study_family": "Distinguish 3 CAD, hypertension and smoker reports from 2 mixed endothelial-review/diabetes-boundary citations; acute/sustained exposure, oral/intravenous route, test methods, B1 sharing, denominators/CIs, SD discrepancy and independent replication remain unverified", "independent_replication": "Reports are distinguished from unique trials, independent teams and participant totals; these are not certified here", "observed_result": "The existing citation records a null result with sustained oral treatment in adults with diabetes.", "result_level": "Test, site, exposure, comparator and denominator details and direct relevance to brachial FMD remain unverified. Other vascular tests are not automatically relabeled as FMD and no specific values are created.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete existing review summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-10-06T12:55:15.444738+09:00", "qualification": "PMID12241530 · DOI10.1042/cs1030339 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External abstract", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID12241530 · DOI10.1042/cs1030339 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "External full text", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID12241530 · DOI10.1042/cs1030339 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID12241530 · DOI10.1042/cs1030339 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." }, { "material_type": "Protocol and analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": null, "qualification": "PMID12241530 · DOI10.1042/cs1030339 is retained in the existing stored record. External abstracts, full text, registration, protocols and analysis plans are unread. Historical verification wording does not establish current reading or certify independence. The stored-summary date is its original production timestamp; dates for unread external materials are empty. The existing evidence date is distinguished from any current external reading date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/12241530/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "The 5 stored reports comprise 3 direct trial reports and 2 bibliographic records for a mixed endothelial-function review and a diabetes vascular-test boundary. The hypertension report’s B1-related sample and review inclusion remain unverified. Unique trial and participant totals are not established." }, "history": [ { "date": "2026-10-21", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public-facing views and materials were prepared from the existing 32 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-21" }