{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3017-main",
  "verdict_number": "3017",
  "title": "Oral vitamin C × blood pressure: short-term SBP signals and gaps in sustained effects",
  "view_version": "1.0",
  "view_created_date": "2026-10-21",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The direct population is hypertensive adults taking antihypertensives. Hypertensive and prehypertensive composition is distinguished from supporting or long-term reports in older general populations, diabetes and atrophic gastritis.",
    "intervention": "This concerns oral single-ingredient ascorbic acid supplements. Product-specific tablets, capsules, salts, excipients and manufacturing details remain unverified; foods, combinations and intravenous use are not automatically included.",
    "dose": "Direct-trial 500 mg/day, other-study 500–2000 mg/day and acute 2 g are retained separately. Report-specific products, exposure, adherence and direct optimal-dose comparisons remain unverified.",
    "comparator": "Matched placebo is distinguished from high- versus low-dose active control. Ward vitamin C alone versus placebo is separated from combination-related BP increases with grape seed; details of maintained medication and care remain unverified.",
    "endpoint": "Office and ambulatory SBP and DBP and daytime, nocturnal and 24-hour measures are treated separately. A specific positive SBP or pooled signal is not the same effect on DBP, all windows, durable control or cardiovascular events.",
    "duration": "The direct trial over 6 weeks, 1 month, crossover periods of 3 months, long-term and acute exposure are distinguished. The duration list is not arbitrarily assigned to reports; sustained and post-stopping effects remain unverified.",
    "excluded_extensions": [
      "Existing grade C54, caution, B/S/R0/I2/E+/B1/C0, disabled indicators and empty values are preserved. Historical independent comparisons or grade records are not converted into completed clinical content review in this work.",
      "Oral single-ingredient findings are not extended to foods, combinations or intravenous use. The 500 mg/day, 500–2000 mg/day, acute 2 g and different durations are not converted into optimal doses or individual dosing instructions.",
      "Ward vitamin-C-alone SBP −1.8±0.8 mmHg, P=.03 belongs to its placebo contrast. The SD or SE meaning of ±, exact 95% CI and vitamin-C-alone DBP remain unverified; the combination title or full 4-group result is not transferred into isolated effects or harms.",
      "Duffy withholding of exact adjusted between-group effects, CIs and P values is not filled by pre/post values or 39 in related FMD research. The daytime fall of 2.0±5.2 mmHg, 95% CI 0–3.9 in 40 older adults aged 60–80 is distinguished from office, DBP or full 24-hour benefits.",
      "The long-term report of 439 concerns a different population and high- versus low-dose active control. The 2012 account of 29 RCTs and 2023 account of 20 RCTs, 890 participants and approximate 3 mmHg are not summed or newly assigned as report-specific exact estimates, unique participants, independent replication or each analysis denominator.",
      "Short-term surrogates are separated from durable control, nocturnal pressure and cardiovascular events, and single-ingredient gastrointestinal caution from combination-related BP increases. Unverified or unestablished benefit is not converted into lack of effect, overall safety or antihypertensive replacement."
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which vitamin C and blood-pressure question does this cover?",
      "needed": "Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time",
      "role": "Required",
      "role_reason": "Material on Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: External verification and content review of the question boundary and existing account remain incomplete. No separate subquestions are recorded and no new independence is certified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing question concerns blood-pressure reduction in adults with hypertension or prehypertension. Directly studied adults taking antihypertensives are distinguished from supporting reports in other populations.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "External verification and content review of the question boundary and existing account remain incomplete. No separate subquestions are recorded and no new independence is certified.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "External verification and content review of the question boundary and existing account remain incomplete. No separate subquestions are recorded and no new independence is certified."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How much is known about the single-ingredient formulation and source?",
      "needed": "Ascorbic acid, tablets, capsules, salts, excipients and feedstock",
      "role": "Required",
      "role_reason": "Material on Ascorbic acid, tablets, capsules, salts, excipients and feedstock is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Ascorbic acid, tablets, capsules, salts, excipients and feedstock must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Feedstock, manufacture, country and study-specific tablets, capsules, salts and excipients remain unverified. Foods, combinations and intravenous administration are not automatically included. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account concerns an oral single-ingredient ascorbic-acid supplement as a purified nutrient. A plant part is not applicable.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Feedstock, manufacture, country and study-specific tablets, capsules, salts and excipients remain unverified. Foods, combinations and intravenous administration are not automatically included.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Feedstock, manufacture, country and study-specific tablets, capsules, salts and excipients remain unverified. Foods, combinations and intravenous administration are not automatically included."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Can 500 mg/day and other doses be read as the same effect?",
      "needed": "Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g",
      "role": "Required",
      "role_reason": "Material on Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact report-specific products, doses, adherence and direct comparisons of an optimal dose remain unverified. Dose superiority is not calculated from numbers in different studies. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing dose records distinguish direct-trial 500 mg/day, other-study 500–2000 mg/day and acute 2 g.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact report-specific products, doses, adherence and direct comparisons of an optimal dose remain unverified. Dose superiority is not calculated from numbers in different studies.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact report-specific products, doses, adherence and direct comparisons of an optimal dose remain unverified. Dose superiority is not calculated from numbers in different studies."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "How are 6 weeks and other durations distinguished?",
      "needed": "Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure",
      "role": "Required",
      "role_reason": "Material on Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific starts, ends, visits, exact long-term durations and complete outcome-time mappings remain unverified. The duration list is not arbitrarily assigned to each report. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing records distinguish the direct trial over 6 weeks, 1 month, crossover periods of 3 months and long-term research.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Report-specific starts, ends, visits, exact long-term durations and complete outcome-time mappings remain unverified. The duration list is not arbitrarily assigned to each report.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific starts, ends, visits, exact long-term durations and complete outcome-time mappings remain unverified. The duration list is not arbitrarily assigned to each report."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Do all reports directly concern hypertensive or prehypertensive adults?",
      "needed": "Diagnosis, medication, age, baseline conditions and population composition",
      "role": "Required",
      "role_reason": "Material on Diagnosis, medication, age, baseline conditions and population composition is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Diagnosis, medication, age, baseline conditions and population composition must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Hypertensive and prehypertensive counts, diagnostic criteria and relevant subgroups in mixed reports remain unverified. Other populations' results are not converted into the same effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The direct population is hypertensive adults taking antihypertensives. Older general-population and diabetic groups are separate supporting evidence.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Hypertensive and prehypertensive counts, diagnostic criteria and relevant subgroups in mixed reports remain unverified. Other populations' results are not converted into the same effect.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Hypertensive and prehypertensive counts, diagnostic criteria and relevant subgroups in mixed reports remain unverified. Other populations' results are not converted into the same effect."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are differences by baseline vitamin C and blood pressure known?",
      "needed": "Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups",
      "role": "Required",
      "role_reason": "Material on Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific vitamin C deficiency, concentrations, baseline pressure and prespecified subgroup results are absent from the stored summary. No new population-specific effect is calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account states that trials with different populations and baseline pressure were not simply combined as the same effect.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Study-specific vitamin C deficiency, concentrations, baseline pressure and prespecified subgroup results are absent from the stored summary. No new population-specific effect is calculated.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Study-specific vitamin C deficiency, concentrations, baseline pressure and prespecified subgroup results are absent from the stored summary. No new population-specific effect is calculated."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are placebo and low-dose active control the same comparison?",
      "needed": "Matched placebo, high-dose and low-dose active controls and direct contrasts",
      "role": "Required",
      "role_reason": "Material on Matched placebo, high-dose and low-dose active controls and direct contrasts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Matched placebo, high-dose and low-dose active controls and direct contrasts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact placebo composition, matching of concurrent care and long-term active-control doses remain unverified. Different comparisons are not treated as identical. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing question uses matched placebo as its main comparison, separating grape-seed combinations and low-dose active control.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact placebo composition, matching of concurrent care and long-term active-control doses remain unverified. Different comparisons are not treated as identical.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact placebo composition, matching of concurrent care and long-term active-control doses remain unverified. Different comparisons are not treated as identical."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How were existing antihypertensives maintained?",
      "needed": "Medication types, doses, changes, adherence and additional care",
      "role": "Required",
      "role_reason": "Material on Medication types, doses, changes, adherence and additional care is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Medication types, doses, changes, adherence and additional care must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific medication, changes, withdrawals and additional care remain unverified. Supplement findings are not extended into evidence for replacing or stopping antihypertensives. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account treats maintenance of medication as an important boundary. It concerns adding a supplement to existing blood-pressure care or comparing with placebo.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group-specific medication, changes, withdrawals and additional care remain unverified. Supplement findings are not extended into evidence for replacing or stopping antihypertensives.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group-specific medication, changes, withdrawals and additional care remain unverified. Supplement findings are not extended into evidence for replacing or stopping antihypertensives."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the pressure units, devices and repeated measurements?",
      "needed": "mmHg, SBP, DBP, devices, posture, repetition, averaging and timing",
      "role": "Required",
      "role_reason": "Material on mmHg, SBP, DBP, devices, posture, repetition, averaging and timing is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on mmHg, SBP, DBP, devices, posture, repetition, averaging and timing must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific devices, calibration, posture, measurement counts, averaging rules and visit times remain unverified. Measurement methods and results are distinguished. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing outcomes use mmHg, treating office SBP and DBP separately from ambulatory SBP and DBP.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Study-specific devices, calibration, posture, measurement counts, averaging rules and visit times remain unverified. Measurement methods and results are distinguished.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Study-specific devices, calibration, posture, measurement counts, averaging rules and visit times remain unverified. Measurement methods and results are distinguished."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are office and ambulatory pressure the same outcome?",
      "needed": "Estimates and denominators for office, daytime and full ambulatory pressure",
      "role": "Required",
      "role_reason": "Material on Estimates and denominators for office, daytime and full ambulatory pressure is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Estimates and denominators for office, daytime and full ambulatory pressure must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Measurement windows, selected analyses, exact denominators and office values remain unverified. Different measurement results are not combined into one effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R03"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing records separate office and ambulatory pressure. Ward concerns 24-hour ambulatory measurement, while the older-person trial distinguishes daytime effects from office results.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Measurement windows, selected analyses, exact denominators and office values remain unverified. Different measurement results are not combined into one effect.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Measurement windows, selected analyses, exact denominators and office values remain unverified. Different measurement results are not combined into one effect."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Can daytime SBP be converted into nocturnal or 24-hour benefit?",
      "needed": "Daytime, nocturnal and 24-hour windows and their separate results",
      "role": "Required",
      "role_reason": "Material on Daytime, nocturnal and 24-hour windows and their separate results is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Daytime, nocturnal and 24-hour windows and their separate results must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Complete nocturnal and 24-hour estimates, intervals, denominators and sleep-time definitions remain unverified. A specific positive contrast is not extended to every window. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R03",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing synthesis records that 24-hour and nocturnal benefits were not established. Fotherby's daytime value is also not converted into a full 24-hour effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Complete nocturnal and 24-hour estimates, intervals, denominators and sleep-time definitions remain unverified. A specific positive contrast is not extended to every window.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete nocturnal and 24-hour estimates, intervals, denominators and sleep-time definitions remain unverified. A specific positive contrast is not extended to every window."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Does a positive SBP finding mean the same result for DBP?",
      "needed": "Separate SBP and DBP values, denominators, intervals, tests and hierarchy",
      "role": "Required",
      "role_reason": "Material on Separate SBP and DBP values, denominators, intervals, tests and hierarchy is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Separate SBP and DBP values, denominators, intervals, tests and hierarchy must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Ward's exact vitamin-C-alone DBP value and full DBP effects, intervals and hierarchy across reports remain unverified. SBP values do not fill these gaps. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account records that a specific positive SBP finding does not establish the same result for DBP, nocturnal pressure or long-term control.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Ward's exact vitamin-C-alone DBP value and full DBP effects, intervals and hierarchy across reports remain unverified. SBP values do not fill these gaps.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Ward's exact vitamin-C-alone DBP value and full DBP effects, intervals and hierarchy across reports remain unverified. SBP values do not fill these gaps."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Which contrast was used in Ward's 4-group trial?",
      "needed": "The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts",
      "role": "Required",
      "role_reason": "Material on The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific allocation, products, background care, interaction plans and prespecified contrasts remain unverified. Combination and single-ingredient groups are separated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing design is a double-blind 4-group randomized trial. Only vitamin C alone versus placebo is used as direct blood-pressure evidence.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group-specific allocation, products, background care, interaction plans and prespecified contrasts remain unverified. Combination and single-ingredient groups are separated.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group-specific allocation, products, background care, interaction plans and prespecified contrasts remain unverified. Combination and single-ingredient groups are separated."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is Ward's SBP value for vitamin C alone versus placebo?",
      "needed": "Direction, mmHg, P value and level of the single-ingredient contrast",
      "role": "Required",
      "role_reason": "Material on Direction, mmHg, P value and level of the single-ingredient contrast is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Direction, mmHg, P value and level of the single-ingredient contrast must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The exact 95% CI, adjustment, effect of interest and vitamin-C-alone DBP remain unverified. The full 4-group result, pre/post changes and combination results are not converted into the isolated effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing result is vitamin C alone versus placebo SBP −1.8±0.8 mmHg, P=.03.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The exact 95% CI, adjustment, effect of interest and vitamin-C-alone DBP remain unverified. The full 4-group result, pre/post changes and combination results are not converted into the isolated effect.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The exact 95% CI, adjustment, effect of interest and vitamin-C-alone DBP remain unverified. The full 4-group result, pre/post changes and combination results are not converted into the isolated effect."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are Ward's 69 total participants the contrast-analysis denominator?",
      "needed": "Distinguishing total, group assignment, analysis, measurement windows and missingness",
      "role": "Required",
      "role_reason": "Material on Distinguishing total, group assignment, analysis, measurement windows and missingness is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing total, group assignment, analysis, measurement windows and missingness must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group assignment, attrition, SBP, DBP and ambulatory analysis denominators and ITT or PP remain unverified. The 69 participants are not copied into each outcome or harm denominator. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing sample record is 69 total participants; vitamin-C-alone and placebo arm analysis counts remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group assignment, attrition, SBP, DBP and ambulatory analysis denominators and ITT or PP remain unverified. The 69 participants are not copied into each outcome or harm denominator.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group assignment, attrition, SBP, DBP and ambulatory analysis denominators and ITT or PP remain unverified. The 69 participants are not copied into each outcome or harm denominator."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What does Ward's ±0.8 mean?",
      "needed": "Distinguishing SD and SE, the exact 95% CI and analysis model",
      "role": "Required",
      "role_reason": "Material on Distinguishing SD and SE, the exact 95% CI and analysis model is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing SD and SE, the exact 95% CI and analysis model must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The ± type, standard error, variance, valid denominator and original CI inputs remain unverified. No new interval, variance or sample size is calculated from ±0.8. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing result explicitly leaves the SD or SE meaning of ± and the exact 95% CI unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The ± type, standard error, variance, valid denominator and original CI inputs remain unverified. No new interval, variance or sample size is calculated from ±0.8.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The ± type, standard error, variance, valid denominator and original CI inputs remain unverified. No new interval, variance or sample size is calculated from ±0.8."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Can the grape-seed combination's pressure increase be attributed to vitamin C alone?",
      "needed": "Combination groups, isolated contrasts, the paper title and interaction",
      "role": "Required",
      "role_reason": "Material on Combination groups, isolated contrasts, the paper title and interaction is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Combination groups, isolated contrasts, the paper title and interaction must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The combination's exact increase, denominator, interval, cause and interaction remain unverified. A 4-group title or overall result is not transferred into a vitamin-C-alone harm estimate. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The paper title concerns increased pressure with vitamin C and grape-seed polyphenols combined. The existing citation account does not attribute that harm to the single ingredient.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The combination's exact increase, denominator, interval, cause and interaction remain unverified. A 4-group title or overall result is not transferred into a vitamin-C-alone harm estimate.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The combination's exact increase, denominator, interval, cause and interaction remain unverified. A 4-group title or overall result is not transferred into a vitamin-C-alone harm estimate."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "How does Duffy's BP report relate to associated FMD research?",
      "needed": "The original BP report, related investigators, cohort and outcome identity",
      "role": "Required",
      "role_reason": "Material on The original BP report, related investigators, cohort and outcome identity is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The original BP report, related investigators, cohort and outcome identity must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact participant correspondence, overlap, inclusion and registry identity remain unverified. Related FMD or other verdict results are not imported as BP efficacy. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Duffy is a placebo-controlled hypertension report. The existing account describes related FMD research from the same investigators and a related cohort, without counting it as independent replication.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact participant correspondence, overlap, inclusion and registry identity remain unverified. Related FMD or other verdict results are not imported as BP efficacy.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact participant correspondence, overlap, inclusion and registry identity remain unverified. Related FMD or other verdict results are not imported as BP efficacy."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Can the 39 participants in related FMD research serve as Duffy's BP denominator?",
      "needed": "Original BP assignment and analysis denominators versus related-report counts",
      "role": "Required",
      "role_reason": "Material on Original BP assignment and analysis denominators versus related-report counts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Original BP assignment and analysis denominators versus related-report counts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Original BP group and outcome denominators, attrition and correspondence of the 39 participants to BP results remain unverified. Related-report counts are not converted into original denominators. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing record leaves original BP trial and analysis denominators unverified while specifying 39 in the related FMD paper.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original BP group and outcome denominators, attrition and correspondence of the 39 participants to BP results remain unverified. Related-report counts are not converted into original denominators.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original BP group and outcome denominators, attrition and correspondence of the 39 participants to BP results remain unverified. Related-report counts are not converted into original denominators."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Which numerical findings were held back for Duffy?",
      "needed": "Exact adjusted between-group effects, 95% CIs, P values and pre/post values",
      "role": "Required",
      "role_reason": "Material on Exact adjusted between-group effects, 95% CIs, P values and pre/post values is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Exact adjusted between-group effects, 95% CIs, P values and pre/post values must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The withheld original effects, intervals, denominators and relationship to media pre/post values remain unverified. Pre/post numbers or estimates do not fill the gaps. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing record preserves reported BP reduction while withholding exact adjusted between-group effects, 95% CIs and P values. The English account also leaves exact adjusted results unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The withheld original effects, intervals, denominators and relationship to media pre/post values remain unverified. Pre/post numbers or estimates do not fill the gaps.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The withheld original effects, intervals, denominators and relationship to media pre/post values remain unverified. Pre/post numbers or estimates do not fill the gaps."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What population do Fotherby's 40 older participants represent?",
      "needed": "Age, hypertension, prehypertension, baseline pressure and denominators",
      "role": "Required",
      "role_reason": "Material on Age, hypertension, prehypertension, baseline pressure and denominators is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Age, hypertension, prehypertension, baseline pressure and denominators must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Whether all were hypertensive, prehypertensive counts, medication, crossover completion and analysis denominators remain unverified. The 40 are not used as every population, outcome or harm denominator. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing sample is 40, with the English account recording ages 60–80. Hypertensive or prehypertensive composition and analysis denominators remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Whether all were hypertensive, prehypertensive counts, medication, crossover completion and analysis denominators remain unverified. The 40 are not used as every population, outcome or harm denominator.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Whether all were hypertensive, prehypertensive counts, medication, crossover completion and analysis denominators remain unverified. The 40 are not used as every population, outcome or harm denominator."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What are Fotherby's daytime SBP and unestablished-benefit results?",
      "needed": "Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP",
      "role": "Required",
      "role_reason": "Material on Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The definition of ±5.2, exact contrast, denominator, nocturnal and 24-hour results, P value and footnotes remain unverified. A reported fall is not arbitrarily negated or converted into full ambulatory benefit. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing result is a daytime SBP fall of 2.0±5.2 mmHg, 95% CI 0–3.9. Office and DBP benefits remain unestablished.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The definition of ±5.2, exact contrast, denominator, nocturnal and 24-hour results, P value and footnotes remain unverified. A reported fall is not arbitrarily negated or converted into full ambulatory benefit.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The definition of ±5.2, exact contrast, denominator, nocturnal and 24-hour results, P value and footnotes remain unverified. A reported fall is not arbitrarily negated or converted into full ambulatory benefit."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Were order, washout and carryover verified in the older-person crossover trial?",
      "needed": "Crossover sequence, periods, washout, pairing and original analysis",
      "role": "Required",
      "role_reason": "Material on Crossover sequence, periods, washout, pairing and original analysis is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Crossover sequence, periods, washout, pairing and original analysis must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The report's original sequence and period tables, washout, carryover, paired analysis and period-specific denominators remain unverified. Periods are not counted as new trials or participants. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing design is a double-blind placebo crossover trial. Existing duration records distinguish crossover periods of 3 months from other durations.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The report's original sequence and period tables, washout, carryover, paired analysis and period-specific denominators remain unverified. Periods are not counted as new trials or participants.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The report's original sequence and period tables, washout, carryover, paired analysis and period-specific denominators remain unverified. Periods are not counted as new trials or participants."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Is Kim's long-term high- versus low-dose report a direct placebo replication?",
      "needed": "Atrophic-gastritis population, long-term active control and BP hierarchy",
      "role": "Required",
      "role_reason": "Material on Atrophic-gastritis population, long-term active control and BP hierarchy is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Atrophic-gastritis population, long-term active control and BP hierarchy must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Hypertensive and prehypertensive composition, selection, group doses and applicability of prespecified primary BP outcomes remain unverified. Different-population and active-control boundaries are retained. This records needed materials; no new research was executed.",
      "current_reports": [
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing citation account records high- versus low-dose comparison in a Japanese atrophic-gastritis population. It is not a direct placebo replication in hypertensive patients.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Hypertensive and prehypertensive composition, selection, group doses and applicability of prespecified primary BP outcomes remain unverified. Different-population and active-control boundaries are retained.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Hypertensive and prehypertensive composition, selection, group doses and applicability of prespecified primary BP outcomes remain unverified. Different-population and active-control boundaries are retained."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "What denominator do the 439 participants in the long-term report represent?",
      "needed": "Reported counts, assignment, analysis, groups and follow-up denominators",
      "role": "Required",
      "role_reason": "Material on Reported counts, assignment, analysis, groups and follow-up denominators is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Reported counts, assignment, analysis, groups and follow-up denominators must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group assignment, analysis, long-term attrition and BP or harm denominators remain unverified. The 439 are not used as valid denominators for each time, outcome or harm. This records needed materials; no new research was executed.",
      "current_reports": [
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing sample record reports 439, with analysis denominators unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group assignment, analysis, long-term attrition and BP or harm denominators remain unverified. The 439 are not used as valid denominators for each time, outcome or harm.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group assignment, analysis, long-term attrition and BP or harm denominators remain unverified. The 439 are not used as valid denominators for each time, outcome or harm."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "How does unestablished long-term benefit differ from short-term results?",
      "needed": "Long-term active control, result direction, duration and durability",
      "role": "Required",
      "role_reason": "Material on Long-term active control, result direction, duration and durability is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term active control, result direction, duration and durability must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact effects, intervals, duration, background care and same-population short-term comparisons remain unverified. This report alone establishes neither long-term null effects nor durable benefit. This records needed materials; no new research was executed.",
      "current_reports": [
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing result retains unestablished long-term BP benefit and does not directly combine it with placebo results in hypertensive patients.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact effects, intervals, duration, background care and same-population short-term comparisons remain unverified. This report alone establishes neither long-term null effects nor durable benefit.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact effects, intervals, duration, background care and same-population short-term comparisons remain unverified. This report alone establishes neither long-term null effects nor durable benefit."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What does the 2012 meta-analysis record for 29 RCTs?",
      "needed": "The existing 29 RCT account, short-term BP, inclusion, outcomes and populations",
      "role": "Required",
      "role_reason": "Material on The existing 29 RCT account, short-term BP, inclusion, outcomes and populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The existing 29 RCT account, short-term BP, inclusion, outcomes and populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Inclusion tables, hypertensive or prehypertensive contributions, exact SBP and DBP effects, CIs, durations, doses and extraction remain unverified. The overall signal is not newly assigned as this report's exact estimate. This records needed materials; no new research was executed.",
      "current_reports": [
        "R05"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing citation records short-term BP pooling across 29 RCTs. The overall account's approximate 3 mmHg systolic signal is distinguished from this report's exact pooled estimate.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Inclusion tables, hypertensive or prehypertensive contributions, exact SBP and DBP effects, CIs, durations, doses and extraction remain unverified. The overall signal is not newly assigned as this report's exact estimate.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Inclusion tables, hypertensive or prehypertensive contributions, exact SBP and DBP effects, CIs, durations, doses and extraction remain unverified. The overall signal is not newly assigned as this report's exact estimate."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What is the scope of the 2023 report's 20 RCTs and 890 participants?",
      "needed": "The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope",
      "role": "Required",
      "role_reason": "Material on The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact pooled estimates, CIs, group and outcome denominators, inclusion, overlap, single-ingredient oral eligibility and durations remain unverified. The 890 are not used as a direct-trial or universal analysis denominator. This records needed materials; no new research was executed.",
      "current_reports": [
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing citation records an approximate 3 mmHg SBP signal across 20 RCTs and 890 participants.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact pooled estimates, CIs, group and outcome denominators, inclusion, overlap, single-ingredient oral eligibility and durations remain unverified. The 890 are not used as a direct-trial or universal analysis denominator.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact pooled estimates, CIs, group and outcome denominators, inclusion, overlap, single-ingredient oral eligibility and durations remain unverified. The 890 are not used as a direct-trial or universal analysis denominator."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Can 29, 20 and the direct reports be added as independent replications?",
      "needed": "Meta-analysis overlap, reports, trials, cohort relationships and unique counts",
      "role": "Required",
      "role_reason": "Material on Meta-analysis overlap, reports, trials, cohort relationships and unique counts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Meta-analysis overlap, reports, trials, cohort relationships and unique counts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual overlap between the meta-analyses, inclusion and extraction of direct reports and unique trials or participants remain unverified. Neither 29+20 nor direct reports plus reviews are summed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing records contain 4 direct-evidence entries, 6 citations and accounts of 29 and 20 RCTs. The restriction on independently counting Duffy's related cohort is also retained.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Actual overlap between the meta-analyses, inclusion and extraction of direct reports and unique trials or participants remain unverified. Neither 29+20 nor direct reports plus reviews are summed.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual overlap between the meta-analyses, inclusion and extraction of direct reports and unique trials or participants remain unverified. Neither 29+20 nor direct reports plus reviews are summed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Were prespecified primary BP outcomes and analysis hierarchy verified?",
      "needed": "Registration, protocols, SBP, DBP, time windows and prespecified analysis",
      "role": "Required",
      "role_reason": "Material on Registration, protocols, SBP, DBP, time windows and prespecified analysis is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Registration, protocols, SBP, DBP, time windows and prespecified analysis must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Registry content, protocols, SAPs, prespecified outcomes, amendment timing and multiplicity remain unverified. Existing primary-outcome labels or a disabled co-primary-split indicator do not certify prespecification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Ward, Duffy, older-person and long-term reports leave prespecified hierarchy or direct applicability as hypertension primary outcomes unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Registry content, protocols, SAPs, prespecified outcomes, amendment timing and multiplicity remain unverified. Existing primary-outcome labels or a disabled co-primary-split indicator do not certify prespecification.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registry content, protocols, SAPs, prespecified outcomes, amendment timing and multiplicity remain unverified. Existing primary-outcome labels or a disabled co-primary-split indicator do not certify prespecification."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Do randomization or masking labels establish verified procedures?",
      "needed": "Random sequences, concealment, masking, group balance and control specifications",
      "role": "Required",
      "role_reason": "Material on Random sequences, concealment, masking, group balance and control specifications is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Random sequences, concealment, masking, group balance and control specifications must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Random sequence, concealment, maintained masking, baseline balance and detailed procedures remain unverified because external materials are unread. Design labels or B1 are not converted into passing a new official assessment. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing designs include randomized, double-blind, crossover and high- versus low-dose comparisons.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Random sequence, concealment, maintained masking, baseline balance and detailed procedures remain unverified because external materials are unread. Design labels or B1 are not converted into passing a new official assessment.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Random sequence, concealment, maintained masking, baseline balance and detailed procedures remain unverified because external materials are unread. Design labels or B1 are not converted into passing a new official assessment."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Were between-group, pre/post and crossover contrasts distinguished?",
      "needed": "Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator",
      "role": "Required",
      "role_reason": "Material on Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Effects of interest, analysis populations, covariates, models and isolated contributions remain unverified. Different contrasts are not converted into the same estimate. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account records that uncontrolled pre/post changes or the full 4-group result overstate vitamin C alone if read as its effect. Duffy's adjusted between-group estimate remains withheld.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Effects of interest, analysis populations, covariates, models and isolated contributions remain unverified. Different contrasts are not converted into the same estimate.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Effects of interest, analysis populations, covariates, models and isolated contributions remain unverified. Different contrasts are not converted into the same estimate."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "How were attrition and missing BP data reflected in analyses?",
      "needed": "Group attrition, failed measurements, omissions, adjustment and time-specific analyses",
      "role": "Required",
      "role_reason": "Material on Group attrition, failed measurements, omissions, adjustment and time-specific analyses is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Group attrition, failed measurements, omissions, adjustment and time-specific analyses must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Attrition reasons, valid ambulatory measurements, missingness, post-assignment exclusions and imputation remain unverified. No new excluded counts or effects are calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing sample records retain both total reported counts and unverified analysis denominators.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Attrition reasons, valid ambulatory measurements, missingness, post-assignment exclusions and imputation remain unverified. No new excluded counts or effects are calculated.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Attrition reasons, valid ambulatory measurements, missingness, post-assignment exclusions and imputation remain unverified. No new excluded counts or effects are calculated."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Could selected measurements and reporting explain a difference?",
      "needed": "Devices, assessor masking, valid records, full results and analyses",
      "role": "Required",
      "role_reason": "Material on Devices, assessor masking, valid records, full results and analyses is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Devices, assessor masking, valid records, full results and analyses must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Identical measurement procedures, assessor masking, selective-reporting scope and omitted outcomes remain unverified. Full original results and prespecified plans are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Distinguishing office, daytime, 24-hour and SBP or DBP outcomes is an interpretation boundary in the existing account.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Identical measurement procedures, assessor masking, selective-reporting scope and omitted outcomes remain unverified. Full original results and prespecified plans are needed.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Identical measurement procedures, assessor masking, selective-reporting scope and omitted outcomes remain unverified. Full original results and prespecified plans are needed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "How are results with different populations, doses, durations and measurements handled?",
      "needed": "Populations, single ingredients, combinations, durations, windows and pooled heterogeneity",
      "role": "Required",
      "role_reason": "Material on Populations, single ingredients, combinations, durations, windows and pooled heterogeneity is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Populations, single ingredients, combinations, durations, windows and pooled heterogeneity must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact I², τ², models, prespecified subgroups, individual contributions and influence analyses remain unverified. No new heterogeneity, pooled effect or independent-replication count is calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing synthesis records mostly short and heterogeneous studies. Different doses, durations and populations are not simply combined as the same effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact I², τ², models, prespecified subgroups, individual contributions and influence analyses remain unverified. No new heterogeneity, pooled effect or independent-replication count is calculated.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact I², τ², models, prespecified subgroups, individual contributions and influence analyses remain unverified. No new heterogeneity, pooled effect or independent-replication count is calculated."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "Was the clinical importance of the approximate 3 mmHg signal verified?",
      "needed": "Effects, intervals, clinical thresholds and individual or population applicability",
      "role": "Required",
      "role_reason": "Material on Effects, intervals, clinical thresholds and individual or population applicability is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Effects, intervals, clinical thresholds and individual or population applicability must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact pooled CIs, external clinical thresholds, baseline risks, patient importance and guaranteed individual effects remain unverified. A small mean reduction is not converted into the same effect for everyone. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R03",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account retains an approximate 3 mmHg SBP signal while stating that clinical thresholds and precision were not sufficiently verified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Exact pooled CIs, external clinical thresholds, baseline risks, patient importance and guaranteed individual effects remain unverified. A small mean reduction is not converted into the same effect for everyone.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact pooled CIs, external clinical thresholds, baseline risks, patient importance and guaranteed individual effects remain unverified. A small mean reduction is not converted into the same effect for everyone."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Does short-term BP answer durable-control or cardiovascular-event questions?",
      "needed": "Long-term follow-up, post-stopping durability, target pressure and clinical events",
      "role": "Required",
      "role_reason": "Material on Long-term follow-up, post-stopping durability, target pressure and clinical events is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term follow-up, post-stopping durability, target pressure and clinical events must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Long-term population-specific control, medication needs, clinical-event effects, denominators and intervals remain unverified. Short-term surrogates and clinical events are distinguished. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account records that sustained, 24-hour, nocturnal and cardiovascular-event benefits were not established. Replacing antihypertensives or preventing events exceeds the tested scope.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Long-term population-specific control, medication needs, clinical-event effects, denominators and intervals remain unverified. Short-term surrogates and clinical events are distinguished.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term population-specific control, medication needs, clinical-event effects, denominators and intervals remain unverified. Short-term surrogates and clinical events are distinguished."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Can optimal effects for particular populations or doses be identified?",
      "needed": "Prespecified subgroups, interactions, direct dose comparison and populations",
      "role": "Required",
      "role_reason": "Material on Prespecified subgroups, interactions, direct dose comparison and populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Prespecified subgroups, interactions, direct dose comparison and populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Prespecified contrasts and intervals by hypertension, prehypertension, age, medication, deficiency or dose remain unverified. Optimal doses or population-specific effects are not newly chosen across different studies. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account explains that studies with different doses, durations and populations were not treated as the same effect.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Prespecified contrasts and intervals by hypertension, prehypertension, age, medication, deficiency or dose remain unverified. Optimal doses or population-specific effects are not newly chosen across different studies.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Prespecified contrasts and intervals by hypertension, prehypertension, age, medication, deficiency or dose remain unverified. Optimal doses or population-specific effects are not newly chosen across different studies."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "Were positive, withheld and unestablished-benefit findings all retained?",
      "needed": "Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results",
      "role": "Required",
      "role_reason": "Material on Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: All contrary or null reports under identical conditions, selected results and a complete inclusion list remain unverified. Uncertainty is not declared null and supporting positive values do not replace confirmation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Ward's vitamin-C-alone SBP and older-person daytime signals, unestablished office or DBP benefit, Duffy's withheld exact values and unestablished long-term benefit are preserved separately.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "All contrary or null reports under identical conditions, selected results and a complete inclusion list remain unverified. Uncertainty is not declared null and supporting positive values do not replace confirmation.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "All contrary or null reports under identical conditions, selected results and a complete inclusion list remain unverified. Uncertainty is not declared null and supporting positive values do not replace confirmation."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "How much is known about funding, product provision and employee authors?",
      "needed": "Funding, products, interests, analysis, publication and author roles",
      "role": "Required",
      "role_reason": "Material on Funding, products, interests, analysis, publication and author roles is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Funding, products, interests, analysis, publication and author roles must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Contracts, product provision, interests, analysis and publication independence and meta-analysis interests remain unverified. Existing I2 is not transferred into independence verification in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Ward funding, products and employee authors and Duffy's detailed contracts or manufacturer involvement remain unverified. Fotherby and Kim funding also remain unverified.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Contracts, product provision, interests, analysis and publication independence and meta-analysis interests remain unverified. Existing I2 is not transferred into independence verification in this work.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Contracts, product provision, interests, analysis and publication independence and meta-analysis interests remain unverified. Existing I2 is not transferred into independence verification in this work."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "How do materials read in this work differ from external materials?",
      "needed": "Acquisition and reading of stored summaries, external abstracts, full texts and registration",
      "role": "Required",
      "role_reason": "Material on Acquisition and reading of stored summaries, external abstracts, full texts and registration is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Acquisition and reading of stored summaries, external abstracts, full texts and registration must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual external identity, content, public availability, acquisition and needed details remain unverified. URLs or historical verification wording are not converted into current external verification or access failure. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The complete existing stored summary was read, linking 4 evidence entries and 6 citations to 6 reports. External abstracts, full texts and registration remain unread with access unattempted in this work.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Actual external identity, content, public availability, acquisition and needed details remain unverified. URLs or historical verification wording are not converted into current external verification or access failure.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual external identity, content, public availability, acquisition and needed details remain unverified. URLs or historical verification wording are not converted into current external verification or access failure."
    },
    {
      "item_id": "N42",
      "question_type": "Evidence condition",
      "question": "What do the existing evidence date and historical abstract checks or comparisons record?",
      "needed": "The existing evidence date, correction history, historical access and production time",
      "role": "Required",
      "role_reason": "Material on The existing evidence date, correction history, historical access and production time is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The existing evidence date, correction history, historical access and production time must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Historical search end, actual reading locations, times, correction details and current external content remain unverified. The 2026-09-07 date is not used as completed external reading or content review in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing evidence date is 2026-09-07 and correction history is an empty list. Historical abstract checks, unverified registration and independent comparisons are preserved as original records.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Historical search end, actual reading locations, times, correction details and current external content remain unverified. The 2026-09-07 date is not used as completed external reading or content review in this work.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Historical search end, actual reading locations, times, correction details and current external content remain unverified. The 2026-09-07 date is not used as completed external reading or content review in this work."
    },
    {
      "item_id": "N43",
      "question_type": "Evidence condition",
      "question": "What do the existing Korean and English accounts, C54 and assessment axes record?",
      "needed": "Existing Korean and English accounts, C54, caution, assessment axes and empty history",
      "role": "Required",
      "role_reason": "Material on Existing Korean and English accounts, C54, caution, assessment axes and empty history is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Existing Korean and English accounts, C54, caution, assessment axes and empty history must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Detailed external translation comparison or new clinical or independence certification was not performed. Historical cross-checks and grade records are not converted into completed clinical content review in this work. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Existing C54, caution and B/S/R0/I2/E+/B1/C0 axes are preserved. A disabled no-human-study indicator and empty values are also original verdict records.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Detailed external translation comparison or new clinical or independence certification was not performed. Historical cross-checks and grade records are not converted into completed clinical content review in this work.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Detailed external translation comparison or new clinical or independence certification was not performed. Historical cross-checks and grade records are not converted into completed clinical content review in this work."
    },
    {
      "item_id": "N44",
      "question_type": "Evidence condition",
      "question": "What records concern gastrointestinal harms of high-dose oral vitamin C alone?",
      "needed": "Diarrhea, abdominal discomfort, event definitions, severity and collection",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Diarrhea, abdominal discomfort, event definitions, severity and collection is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Diarrhea, abdominal discomfort, event definitions, severity and collection must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual events, withdrawals, definitions, severity, collection, masking and group-specific counts remain unverified. General cautions are not converted into incidence or no events in this trial. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing safety account retains possible diarrhea or gastrointestinal discomfort with high oral doses and limited trial-specific event counts.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Actual events, withdrawals, definitions, severity, collection, masking and group-specific counts remain unverified. General cautions are not converted into incidence or no events in this trial.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual events, withdrawals, definitions, severity, collection, masking and group-specific counts remain unverified. General cautions are not converted into incidence or no events in this trial."
    },
    {
      "item_id": "N45",
      "question_type": "Evidence condition",
      "question": "Are combination-related pressure increases and single-ingredient gastrointestinal cautions the same harm?",
      "needed": "Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The 4-group comparative harm estimates, baseline and concurrent exposures, interaction and single-ingredient causality remain unverified. The title is not converted into causal BP increases or incidence for vitamin C alone. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The combination-related BP increase in Ward's title is not attributed to the single ingredient. Gastrointestinal caution for high doses of vitamin C alone is a separate record.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The 4-group comparative harm estimates, baseline and concurrent exposures, interaction and single-ingredient causality remain unverified. The title is not converted into causal BP increases or incidence for vitamin C alone.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The 4-group comparative harm estimates, baseline and concurrent exposures, interaction and single-ingredient causality remain unverified. The title is not converted into causal BP increases or incidence for vitamin C alone."
    },
    {
      "item_id": "N46",
      "question_type": "Evidence condition",
      "question": "Can harm frequency and exposure or recovery times be calculated?",
      "needed": "Exposed people, people with events, event counts, observation, stopping and recovery",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Exposed people, people with events, event counts, observation, stopping and recovery is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Exposed people, people with events, event counts, observation, stopping and recovery must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific harm denominators, counts, duplication, onset, recovery, stopping, re-exposure and follow-up loss remain unverified. Incidence or comparative risk is not calculated from cautions lacking denominators or time. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing account records limited trial-specific adverse-event counts. Total sample labels are not used as harm denominators.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group-specific harm denominators, counts, duplication, onset, recovery, stopping, re-exposure and follow-up loss remain unverified. Incidence or comparative risk is not calculated from cautions lacking denominators or time.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group-specific harm denominators, counts, duplication, onset, recovery, stopping, re-exposure and follow-up loss remain unverified. Incidence or comparative risk is not calculated from cautions lacking denominators or time."
    },
    {
      "item_id": "N47",
      "question_type": "Evidence condition",
      "question": "What is the scope of long-term, stone-risk, kidney-disease or iron-overload materials?",
      "needed": "Long-term and rare harms, population-specific exposure, duration and interactions",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Long-term and rare harms, population-specific exposure, duration and interactions is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term and rare harms, population-specific exposure, duration and interactions must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Long-term and rare events, special populations, concurrent medication and risk sizes in hypertensive populations remain unverified. Short-term positive findings or few recorded events are not extended into overall safety or individual dosing instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The existing product account records caution with stone predisposition, kidney disease and iron overload.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Long-term and rare events, special populations, concurrent medication and risk sizes in hypertensive populations remain unverified. Short-term positive findings or few recorded events are not extended into overall safety or individual dosing instructions.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term and rare events, special populations, concurrent medication and risk sizes in hypertensive populations remain unverified. Short-term positive findings or few recorded events are not extended into overall safety or individual dosing instructions."
    },
    {
      "item_id": "N48",
      "question_type": "Evidence condition",
      "question": "Can harms across reports be summed as independent events?",
      "needed": "Unique events, studies, repeated citations and matching efficacy or harm populations",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Unique events, studies, repeated citations and matching efficacy or harm populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Unique events, studies, repeated citations and matching efficacy or harm populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Original-event relationships, repeated citation in reviews, regulatory material and independent event or participant counts remain unverified. Efficacy-report counts or repeated general cautions are not counted as independent harm events. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The stored reports do not link harm estimates to unique events. Existing cautions and combination boundaries are retained by material.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original-event relationships, repeated citation in reviews, regulatory material and independent event or participant counts remain unverified. Efficacy-report counts or repeated general cautions are not counted as independent harm events.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-event relationships, repeated citation in reviews, regulatory material and independent event or participant counts remain unverified. Efficacy-report counts or repeated general cautions are not counted as independent harm events."
    },
    {
      "item_id": "N49",
      "question_type": "Evidence condition",
      "question": "Which existing materials could update the gap record?",
      "needed": "Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events",
      "role": "Required",
      "role_reason": "Material on Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Protocols, group- and time-specific outcomes, ± definitions, meta-analysis inclusion tables, harms and durability materials are needed. Material additions and condition changes are recorded separately; no new research, calculation or regrading is executed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03",
        "R04",
        "R05",
        "R06"
      ],
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete existing Korean and English review summary, question and citations read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "This record preserves existing numbers, unverified fields and withheld values. Direct content review and external verification remain incomplete, and gaps are not filled with effects or frequencies.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the existing stored summary. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Protocols, group- and time-specific outcomes, ± definitions, meta-analysis inclusion tables, harms and durability materials are needed. Material additions and condition changes are recorded separately; no new research, calculation or regrading is executed.",
      "uncertainty": "Exact group, outcome and time-specific denominators, effects of interest, ± definitions, CIs, prespecified hierarchy, meta-analysis inclusion, overlap, clinical thresholds, long-term effects and harms remain unverified. Original positive signals, withheld values, unestablished benefits and historical verification wording are not converted into new calculations, current external reading or completed clinical review.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Protocols, group- and time-specific outcomes, ± definitions, meta-analysis inclusion tables, harms and durability materials are needed. Material additions and condition changes are recorded separately; no new research, calculation or regrading is executed."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Ward et al. 2005",
      "url": "https://pubmed.ncbi.nlm.nih.gov/15662232/",
      "report_type": "Stored summary of a double-blind 4-group randomized trial",
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "The relevant report and citation in the complete existing Korean and English review summary were read. External abstracts, full text, registration, plans, appendices and funding documents remain unread.",
      "study_family": "SF01-Ward-2005-four-arm",
      "independent_replication": "Existing report relationships and I2 and R0 assessments are retained. Exact inclusion, sample overlap, unique totals and independent replication were not verified in this work.",
      "observed_result": "This records 69 total participants and vitamin C alone versus placebo SBP −1.8±0.8 mmHg, P=.03. The SD or SE meaning of ±, exact 95% CI, vitamin-C-alone DBP and arm analysis denominators remain unverified.",
      "result_level": "This records the specific placebo contrast for vitamin C alone. Grape-seed combination BP increases, all-arm results and pre/post changes are not the same isolated effect; prespecified contrasts and detailed analyses remain unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete existing review summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Appendices and full materials",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Funding and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID15662232 and DOI10.1097/00004872-200502000-00026. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/15662232/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Duffy et al. 1999",
      "url": "https://pubmed.ncbi.nlm.nih.gov/10636373/",
      "report_type": "Stored summary of a placebo-controlled hypertension report",
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "The relevant report and citation in the complete existing Korean and English review summary were read. External abstracts, full text, registration, plans, appendices and funding documents remain unread.",
      "study_family": "SF02-Duffy-1999-hypertension-related-cohort",
      "independent_replication": "Existing report relationships and I2 and R0 assessments are retained. Exact inclusion, sample overlap, unique totals and independent replication were not verified in this work.",
      "observed_result": "Reported BP reduction is retained, but exact adjusted between-group effects, 95% CIs and P values are withheld. Original BP denominators remain unverified; 39 in related FMD research is a separate label.",
      "result_level": "This is a supporting early hypertension report. Related investigators and cohort are not added as independent replication, and media pre/post values do not fill withheld estimates.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete existing review summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Appendices and full materials",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "Funding and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10636373 and DOI10.1016/S0140-6736(99)04410-4. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/10636373/"
        }
      ]
    },
    {
      "report_id": "R03",
      "title": "Fotherby et al. 2000",
      "url": "https://pubmed.ncbi.nlm.nih.gov/10779091/",
      "report_type": "Stored summary of a double-blind placebo crossover trial in older adults",
      "existence": "Displayed reports, citations, results and gaps exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "The relevant report and citation in the complete existing Korean and English review summary were read. External abstracts, full text, registration, plans, appendices and funding documents remain unread.",
      "study_family": "SF03-Fotherby-2000-older-crossover",
      "independent_replication": "Existing report relationships and I2 and R0 assessments are retained. Exact inclusion, sample overlap, unique totals and independent replication were not verified in this work.",
      "observed_result": "This records 40 adults aged 60–80 with a daytime SBP fall of 2.0±5.2 mmHg, 95% CI 0–3.9. Office and DBP benefits are unestablished; hypertensive composition, analysis denominators and the ± definition remain unverified.",
      "result_level": "This is a supporting report with different baseline pressure and age. Daytime values are not converted into full 24-hour or nocturnal benefit, and a reported fall is not arbitrarily recalculated as a negative value. Sequence, washout and carryover remain unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete existing review summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10779091 and DOI10.1097/00004872-200018040-00009. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "This is the existing stored record of PMID10779091 and DOI10.1097/00004872-200018040-00009. External reports, registration, plans, full tables, appendices, funding and product involvement details are unread; material existence, acquisition, prespecification or independence was not newly verified. The material date 2026-09-07 is the original evidence date retained for every material entry. It is neither an actual external reading date nor completed content review in this work."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
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    {
      "report_id": "R04",
      "title": "Kim et al. 2002",
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      "observed_result": "This records 439 reported participants and unestablished long-term BP benefit. Analysis denominators remain unverified; it is not directly combined with placebo results in hypertensive patients.",
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    {
      "report_id": "R05",
      "title": "Juraschek et al. 2012",
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      "study_family": "SF05-Juraschek-2012-meta-native",
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    {
      "report_id": "R06",
      "title": "Updated essential-hypertension meta-analysis. 2023",
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      "acquired_read": "The relevant report and citation in the complete existing Korean and English review summary were read. External abstracts, full text, registration, plans, appendices and funding documents remain unread.",
      "study_family": "SF06-updated-2023-essential-hypertension-meta-native",
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      "observed_result": "The existing citation records an approximate 3 mmHg SBP signal across 20 RCTs and 890 participants. It is linked from the stored citation without a separate original evidence entry.",
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      "source_evidence_date": "2026-09-07",
      "materials": [
        {
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        {
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        {
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        {
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      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
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      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
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    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The 4 evidence entries and 6 citations are linked to 6 reports. Ward arms, older-person crossover periods, related Duffy FMD and meta-analysis studies are not counted as new independent trials or participants. The two meta-analyses’ 29/20 RCTs and 890 participants are original accounts; actual overlap and unique trial or participant totals remain unverified."
  },
  "history": [
    {
      "date": "2026-10-21",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public-facing views and materials were prepared from the existing 49 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-21"
}