{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Oral vitamin C × blood pressure: short-term SBP signals and gaps in sustained effects",
  "language": "en",
  "translation_date": "2026-10-21",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which vitamin C and blood-pressure question does this cover?",
      "needed": "Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time",
      "role": "Required",
      "role_reason": "Material on Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Oral single-ingredient vitamin C, hypertension, prehypertension, comparison, measurement and time must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: External verification and content review of the question boundary and existing account remain incomplete. No separate subquestions are recorded and no new independence is certified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How much is known about the single-ingredient formulation and source?",
      "needed": "Ascorbic acid, tablets, capsules, salts, excipients and feedstock",
      "role": "Required",
      "role_reason": "Material on Ascorbic acid, tablets, capsules, salts, excipients and feedstock is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Ascorbic acid, tablets, capsules, salts, excipients and feedstock must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Feedstock, manufacture, country and study-specific tablets, capsules, salts and excipients remain unverified. Foods, combinations and intravenous administration are not automatically included. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Can 500 mg/day and other doses be read as the same effect?",
      "needed": "Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g",
      "role": "Required",
      "role_reason": "Material on Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing direct 500 mg/day, other 500–2000 mg/day and acute 2 g must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact report-specific products, doses, adherence and direct comparisons of an optimal dose remain unverified. Dose superiority is not calculated from numbers in different studies. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "How are 6 weeks and other durations distinguished?",
      "needed": "Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure",
      "role": "Required",
      "role_reason": "Material on Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Direct 6-week research, 1 month, crossover periods of 3 months, long-term and acute exposure must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Report-specific starts, ends, visits, exact long-term durations and complete outcome-time mappings remain unverified. The duration list is not arbitrarily assigned to each report. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Do all reports directly concern hypertensive or prehypertensive adults?",
      "needed": "Diagnosis, medication, age, baseline conditions and population composition",
      "role": "Required",
      "role_reason": "Material on Diagnosis, medication, age, baseline conditions and population composition is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Diagnosis, medication, age, baseline conditions and population composition must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Hypertensive and prehypertensive counts, diagnostic criteria and relevant subgroups in mixed reports remain unverified. Other populations' results are not converted into the same effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are differences by baseline vitamin C and blood pressure known?",
      "needed": "Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups",
      "role": "Required",
      "role_reason": "Material on Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Baseline intake, circulating concentration, pressure, conditions and prespecified subgroups must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific vitamin C deficiency, concentrations, baseline pressure and prespecified subgroup results are absent from the stored summary. No new population-specific effect is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are placebo and low-dose active control the same comparison?",
      "needed": "Matched placebo, high-dose and low-dose active controls and direct contrasts",
      "role": "Required",
      "role_reason": "Material on Matched placebo, high-dose and low-dose active controls and direct contrasts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Matched placebo, high-dose and low-dose active controls and direct contrasts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact placebo composition, matching of concurrent care and long-term active-control doses remain unverified. Different comparisons are not treated as identical. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How were existing antihypertensives maintained?",
      "needed": "Medication types, doses, changes, adherence and additional care",
      "role": "Required",
      "role_reason": "Material on Medication types, doses, changes, adherence and additional care is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Medication types, doses, changes, adherence and additional care must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific medication, changes, withdrawals and additional care remain unverified. Supplement findings are not extended into evidence for replacing or stopping antihypertensives. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the pressure units, devices and repeated measurements?",
      "needed": "mmHg, SBP, DBP, devices, posture, repetition, averaging and timing",
      "role": "Required",
      "role_reason": "Material on mmHg, SBP, DBP, devices, posture, repetition, averaging and timing is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on mmHg, SBP, DBP, devices, posture, repetition, averaging and timing must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Study-specific devices, calibration, posture, measurement counts, averaging rules and visit times remain unverified. Measurement methods and results are distinguished. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are office and ambulatory pressure the same outcome?",
      "needed": "Estimates and denominators for office, daytime and full ambulatory pressure",
      "role": "Required",
      "role_reason": "Material on Estimates and denominators for office, daytime and full ambulatory pressure is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Estimates and denominators for office, daytime and full ambulatory pressure must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Measurement windows, selected analyses, exact denominators and office values remain unverified. Different measurement results are not combined into one effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Can daytime SBP be converted into nocturnal or 24-hour benefit?",
      "needed": "Daytime, nocturnal and 24-hour windows and their separate results",
      "role": "Required",
      "role_reason": "Material on Daytime, nocturnal and 24-hour windows and their separate results is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Daytime, nocturnal and 24-hour windows and their separate results must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Complete nocturnal and 24-hour estimates, intervals, denominators and sleep-time definitions remain unverified. A specific positive contrast is not extended to every window. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Does a positive SBP finding mean the same result for DBP?",
      "needed": "Separate SBP and DBP values, denominators, intervals, tests and hierarchy",
      "role": "Required",
      "role_reason": "Material on Separate SBP and DBP values, denominators, intervals, tests and hierarchy is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Separate SBP and DBP values, denominators, intervals, tests and hierarchy must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Ward's exact vitamin-C-alone DBP value and full DBP effects, intervals and hierarchy across reports remain unverified. SBP values do not fill these gaps. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Which contrast was used in Ward's 4-group trial?",
      "needed": "The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts",
      "role": "Required",
      "role_reason": "Material on The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The 4-group allocation, vitamin C alone, placebo, combination and prespecified contrasts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific allocation, products, background care, interaction plans and prespecified contrasts remain unverified. Combination and single-ingredient groups are separated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What is Ward's SBP value for vitamin C alone versus placebo?",
      "needed": "Direction, mmHg, P value and level of the single-ingredient contrast",
      "role": "Required",
      "role_reason": "Material on Direction, mmHg, P value and level of the single-ingredient contrast is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Direction, mmHg, P value and level of the single-ingredient contrast must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The exact 95% CI, adjustment, effect of interest and vitamin-C-alone DBP remain unverified. The full 4-group result, pre/post changes and combination results are not converted into the isolated effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are Ward's 69 total participants the contrast-analysis denominator?",
      "needed": "Distinguishing total, group assignment, analysis, measurement windows and missingness",
      "role": "Required",
      "role_reason": "Material on Distinguishing total, group assignment, analysis, measurement windows and missingness is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing total, group assignment, analysis, measurement windows and missingness must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group assignment, attrition, SBP, DBP and ambulatory analysis denominators and ITT or PP remain unverified. The 69 participants are not copied into each outcome or harm denominator. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What does Ward's ±0.8 mean?",
      "needed": "Distinguishing SD and SE, the exact 95% CI and analysis model",
      "role": "Required",
      "role_reason": "Material on Distinguishing SD and SE, the exact 95% CI and analysis model is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Distinguishing SD and SE, the exact 95% CI and analysis model must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The ± type, standard error, variance, valid denominator and original CI inputs remain unverified. No new interval, variance or sample size is calculated from ±0.8. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Can the grape-seed combination's pressure increase be attributed to vitamin C alone?",
      "needed": "Combination groups, isolated contrasts, the paper title and interaction",
      "role": "Required",
      "role_reason": "Material on Combination groups, isolated contrasts, the paper title and interaction is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Combination groups, isolated contrasts, the paper title and interaction must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The combination's exact increase, denominator, interval, cause and interaction remain unverified. A 4-group title or overall result is not transferred into a vitamin-C-alone harm estimate. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "How does Duffy's BP report relate to associated FMD research?",
      "needed": "The original BP report, related investigators, cohort and outcome identity",
      "role": "Required",
      "role_reason": "Material on The original BP report, related investigators, cohort and outcome identity is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The original BP report, related investigators, cohort and outcome identity must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact participant correspondence, overlap, inclusion and registry identity remain unverified. Related FMD or other verdict results are not imported as BP efficacy. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Can the 39 participants in related FMD research serve as Duffy's BP denominator?",
      "needed": "Original BP assignment and analysis denominators versus related-report counts",
      "role": "Required",
      "role_reason": "Material on Original BP assignment and analysis denominators versus related-report counts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Original BP assignment and analysis denominators versus related-report counts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Original BP group and outcome denominators, attrition and correspondence of the 39 participants to BP results remain unverified. Related-report counts are not converted into original denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Which numerical findings were held back for Duffy?",
      "needed": "Exact adjusted between-group effects, 95% CIs, P values and pre/post values",
      "role": "Required",
      "role_reason": "Material on Exact adjusted between-group effects, 95% CIs, P values and pre/post values is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Exact adjusted between-group effects, 95% CIs, P values and pre/post values must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The withheld original effects, intervals, denominators and relationship to media pre/post values remain unverified. Pre/post numbers or estimates do not fill the gaps. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What population do Fotherby's 40 older participants represent?",
      "needed": "Age, hypertension, prehypertension, baseline pressure and denominators",
      "role": "Required",
      "role_reason": "Material on Age, hypertension, prehypertension, baseline pressure and denominators is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Age, hypertension, prehypertension, baseline pressure and denominators must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Whether all were hypertensive, prehypertensive counts, medication, crossover completion and analysis denominators remain unverified. The 40 are not used as every population, outcome or harm denominator. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What are Fotherby's daytime SBP and unestablished-benefit results?",
      "needed": "Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP",
      "role": "Required",
      "role_reason": "Material on Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Daytime SBP 2.0±5.2 mmHg, 95% CI 0–3.9 versus office and DBP must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The definition of ±5.2, exact contrast, denominator, nocturnal and 24-hour results, P value and footnotes remain unverified. A reported fall is not arbitrarily negated or converted into full ambulatory benefit. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Were order, washout and carryover verified in the older-person crossover trial?",
      "needed": "Crossover sequence, periods, washout, pairing and original analysis",
      "role": "Required",
      "role_reason": "Material on Crossover sequence, periods, washout, pairing and original analysis is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Crossover sequence, periods, washout, pairing and original analysis must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The report's original sequence and period tables, washout, carryover, paired analysis and period-specific denominators remain unverified. Periods are not counted as new trials or participants. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Is Kim's long-term high- versus low-dose report a direct placebo replication?",
      "needed": "Atrophic-gastritis population, long-term active control and BP hierarchy",
      "role": "Required",
      "role_reason": "Material on Atrophic-gastritis population, long-term active control and BP hierarchy is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Atrophic-gastritis population, long-term active control and BP hierarchy must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Hypertensive and prehypertensive composition, selection, group doses and applicability of prespecified primary BP outcomes remain unverified. Different-population and active-control boundaries are retained. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "What denominator do the 439 participants in the long-term report represent?",
      "needed": "Reported counts, assignment, analysis, groups and follow-up denominators",
      "role": "Required",
      "role_reason": "Material on Reported counts, assignment, analysis, groups and follow-up denominators is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Reported counts, assignment, analysis, groups and follow-up denominators must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group assignment, analysis, long-term attrition and BP or harm denominators remain unverified. The 439 are not used as valid denominators for each time, outcome or harm. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "How does unestablished long-term benefit differ from short-term results?",
      "needed": "Long-term active control, result direction, duration and durability",
      "role": "Required",
      "role_reason": "Material on Long-term active control, result direction, duration and durability is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term active control, result direction, duration and durability must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact effects, intervals, duration, background care and same-population short-term comparisons remain unverified. This report alone establishes neither long-term null effects nor durable benefit. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What does the 2012 meta-analysis record for 29 RCTs?",
      "needed": "The existing 29 RCT account, short-term BP, inclusion, outcomes and populations",
      "role": "Required",
      "role_reason": "Material on The existing 29 RCT account, short-term BP, inclusion, outcomes and populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The existing 29 RCT account, short-term BP, inclusion, outcomes and populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Inclusion tables, hypertensive or prehypertensive contributions, exact SBP and DBP effects, CIs, durations, doses and extraction remain unverified. The overall signal is not newly assigned as this report's exact estimate. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What is the scope of the 2023 report's 20 RCTs and 890 participants?",
      "needed": "The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope",
      "role": "Required",
      "role_reason": "Material on The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The 20 RCTs, 890 participants, approximate 3 mmHg SBP and population or denominator scope must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact pooled estimates, CIs, group and outcome denominators, inclusion, overlap, single-ingredient oral eligibility and durations remain unverified. The 890 are not used as a direct-trial or universal analysis denominator. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Can 29, 20 and the direct reports be added as independent replications?",
      "needed": "Meta-analysis overlap, reports, trials, cohort relationships and unique counts",
      "role": "Required",
      "role_reason": "Material on Meta-analysis overlap, reports, trials, cohort relationships and unique counts is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Meta-analysis overlap, reports, trials, cohort relationships and unique counts must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual overlap between the meta-analyses, inclusion and extraction of direct reports and unique trials or participants remain unverified. Neither 29+20 nor direct reports plus reviews are summed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Were prespecified primary BP outcomes and analysis hierarchy verified?",
      "needed": "Registration, protocols, SBP, DBP, time windows and prespecified analysis",
      "role": "Required",
      "role_reason": "Material on Registration, protocols, SBP, DBP, time windows and prespecified analysis is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Registration, protocols, SBP, DBP, time windows and prespecified analysis must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Registry content, protocols, SAPs, prespecified outcomes, amendment timing and multiplicity remain unverified. Existing primary-outcome labels or a disabled co-primary-split indicator do not certify prespecification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Do randomization or masking labels establish verified procedures?",
      "needed": "Random sequences, concealment, masking, group balance and control specifications",
      "role": "Required",
      "role_reason": "Material on Random sequences, concealment, masking, group balance and control specifications is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Random sequences, concealment, masking, group balance and control specifications must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Random sequence, concealment, maintained masking, baseline balance and detailed procedures remain unverified because external materials are unread. Design labels or B1 are not converted into passing a new official assessment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Were between-group, pre/post and crossover contrasts distinguished?",
      "needed": "Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator",
      "role": "Required",
      "role_reason": "Material on Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Adjustment, analysis populations, ITT, PP, crossover, effect of interest and denominator must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Effects of interest, analysis populations, covariates, models and isolated contributions remain unverified. Different contrasts are not converted into the same estimate. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "How were attrition and missing BP data reflected in analyses?",
      "needed": "Group attrition, failed measurements, omissions, adjustment and time-specific analyses",
      "role": "Required",
      "role_reason": "Material on Group attrition, failed measurements, omissions, adjustment and time-specific analyses is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Group attrition, failed measurements, omissions, adjustment and time-specific analyses must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Attrition reasons, valid ambulatory measurements, missingness, post-assignment exclusions and imputation remain unverified. No new excluded counts or effects are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Could selected measurements and reporting explain a difference?",
      "needed": "Devices, assessor masking, valid records, full results and analyses",
      "role": "Required",
      "role_reason": "Material on Devices, assessor masking, valid records, full results and analyses is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Devices, assessor masking, valid records, full results and analyses must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Identical measurement procedures, assessor masking, selective-reporting scope and omitted outcomes remain unverified. Full original results and prespecified plans are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "How are results with different populations, doses, durations and measurements handled?",
      "needed": "Populations, single ingredients, combinations, durations, windows and pooled heterogeneity",
      "role": "Required",
      "role_reason": "Material on Populations, single ingredients, combinations, durations, windows and pooled heterogeneity is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Populations, single ingredients, combinations, durations, windows and pooled heterogeneity must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact I², τ², models, prespecified subgroups, individual contributions and influence analyses remain unverified. No new heterogeneity, pooled effect or independent-replication count is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "Was the clinical importance of the approximate 3 mmHg signal verified?",
      "needed": "Effects, intervals, clinical thresholds and individual or population applicability",
      "role": "Required",
      "role_reason": "Material on Effects, intervals, clinical thresholds and individual or population applicability is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Effects, intervals, clinical thresholds and individual or population applicability must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Exact pooled CIs, external clinical thresholds, baseline risks, patient importance and guaranteed individual effects remain unverified. A small mean reduction is not converted into the same effect for everyone. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Does short-term BP answer durable-control or cardiovascular-event questions?",
      "needed": "Long-term follow-up, post-stopping durability, target pressure and clinical events",
      "role": "Required",
      "role_reason": "Material on Long-term follow-up, post-stopping durability, target pressure and clinical events is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term follow-up, post-stopping durability, target pressure and clinical events must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Long-term population-specific control, medication needs, clinical-event effects, denominators and intervals remain unverified. Short-term surrogates and clinical events are distinguished. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "Can optimal effects for particular populations or doses be identified?",
      "needed": "Prespecified subgroups, interactions, direct dose comparison and populations",
      "role": "Required",
      "role_reason": "Material on Prespecified subgroups, interactions, direct dose comparison and populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Prespecified subgroups, interactions, direct dose comparison and populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Prespecified contrasts and intervals by hypertension, prehypertension, age, medication, deficiency or dose remain unverified. Optimal doses or population-specific effects are not newly chosen across different studies. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "Were positive, withheld and unestablished-benefit findings all retained?",
      "needed": "Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results",
      "role": "Required",
      "role_reason": "Material on Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Vitamin-C-alone SBP, office pressure, DBP, Duffy's withheld values and long-term results must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: All contrary or null reports under identical conditions, selected results and a complete inclusion list remain unverified. Uncertainty is not declared null and supporting positive values do not replace confirmation. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "How much is known about funding, product provision and employee authors?",
      "needed": "Funding, products, interests, analysis, publication and author roles",
      "role": "Required",
      "role_reason": "Material on Funding, products, interests, analysis, publication and author roles is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Funding, products, interests, analysis, publication and author roles must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Contracts, product provision, interests, analysis and publication independence and meta-analysis interests remain unverified. Existing I2 is not transferred into independence verification in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "How do materials read in this work differ from external materials?",
      "needed": "Acquisition and reading of stored summaries, external abstracts, full texts and registration",
      "role": "Required",
      "role_reason": "Material on Acquisition and reading of stored summaries, external abstracts, full texts and registration is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Acquisition and reading of stored summaries, external abstracts, full texts and registration must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual external identity, content, public availability, acquisition and needed details remain unverified. URLs or historical verification wording are not converted into current external verification or access failure. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N42",
      "question_type": "Evidence condition",
      "question": "What do the existing evidence date and historical abstract checks or comparisons record?",
      "needed": "The existing evidence date, correction history, historical access and production time",
      "role": "Required",
      "role_reason": "Material on The existing evidence date, correction history, historical access and production time is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on The existing evidence date, correction history, historical access and production time must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Historical search end, actual reading locations, times, correction details and current external content remain unverified. The 2026-09-07 date is not used as completed external reading or content review in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N43",
      "question_type": "Evidence condition",
      "question": "What do the existing Korean and English accounts, C54 and assessment axes record?",
      "needed": "Existing Korean and English accounts, C54, caution, assessment axes and empty history",
      "role": "Required",
      "role_reason": "Material on Existing Korean and English accounts, C54, caution, assessment axes and empty history is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Existing Korean and English accounts, C54, caution, assessment axes and empty history must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Detailed external translation comparison or new clinical or independence certification was not performed. Historical cross-checks and grade records are not converted into completed clinical content review in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N44",
      "question_type": "Evidence condition",
      "question": "What records concern gastrointestinal harms of high-dose oral vitamin C alone?",
      "needed": "Diarrhea, abdominal discomfort, event definitions, severity and collection",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Diarrhea, abdominal discomfort, event definitions, severity and collection is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Diarrhea, abdominal discomfort, event definitions, severity and collection must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Actual events, withdrawals, definitions, severity, collection, masking and group-specific counts remain unverified. General cautions are not converted into incidence or no events in this trial. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N45",
      "question_type": "Evidence condition",
      "question": "Are combination-related pressure increases and single-ingredient gastrointestinal cautions the same harm?",
      "needed": "Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Grape-seed combinations, vitamin C alone, event definitions, contribution and alternatives must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: The 4-group comparative harm estimates, baseline and concurrent exposures, interaction and single-ingredient causality remain unverified. The title is not converted into causal BP increases or incidence for vitamin C alone. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N46",
      "question_type": "Evidence condition",
      "question": "Can harm frequency and exposure or recovery times be calculated?",
      "needed": "Exposed people, people with events, event counts, observation, stopping and recovery",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Exposed people, people with events, event counts, observation, stopping and recovery is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Exposed people, people with events, event counts, observation, stopping and recovery must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Group-specific harm denominators, counts, duplication, onset, recovery, stopping, re-exposure and follow-up loss remain unverified. Incidence or comparative risk is not calculated from cautions lacking denominators or time. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N47",
      "question_type": "Evidence condition",
      "question": "What is the scope of long-term, stone-risk, kidney-disease or iron-overload materials?",
      "needed": "Long-term and rare harms, population-specific exposure, duration and interactions",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Long-term and rare harms, population-specific exposure, duration and interactions is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Long-term and rare harms, population-specific exposure, duration and interactions must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Long-term and rare events, special populations, concurrent medication and risk sizes in hypertensive populations remain unverified. Short-term positive findings or few recorded events are not extended into overall safety or individual dosing instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N48",
      "question_type": "Evidence condition",
      "question": "Can harms across reports be summed as independent events?",
      "needed": "Unique events, studies, repeated citations and matching efficacy or harm populations",
      "role": "Supplementary; required for the relevant harm scope",
      "role_reason": "Material on Unique events, studies, repeated citations and matching efficacy or harm populations is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Unique events, studies, repeated citations and matching efficacy or harm populations must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Original-event relationships, repeated citation in reviews, regulatory material and independent event or participant counts remain unverified. Efficacy-report counts or repeated general cautions are not counted as independent harm events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N49",
      "question_type": "Evidence condition",
      "question": "Which existing materials could update the gap record?",
      "needed": "Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events",
      "role": "Required",
      "role_reason": "Material on Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events is needed to connect oral single-ingredient treatment, populations, maintained medication, comparators, BP measurement, time points, denominators, precision and harms.",
      "application_exception": "Existing C54, caution, assessment axes and empty values are retained. Oral single ingredients are distinguished from foods, combinations and intravenous use; placebo from active controls; SBP and DBP by window; and short-term BP from durability and events. No new effects, CIs, dispersion, attrition, incidence, unique totals, grades, optimal doses or individual dosing guidance are created.",
      "criterion": "Original records on Original contrasts, CIs, group and outcome denominators, prespecified hierarchy and change events must link to the same question, product, population, comparator, measurement, time point and denominator, distinguishing single ingredients, combinations, active controls, daytime, nocturnal and sustained effects.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These evidence conditions apply to the existing question of oral single-ingredient vitamin C and blood pressure. They do not establish new preregistration, execution of an official assessment tool or independent clinical validation.",
      "proposed_research": "Material needed: Protocols, group- and time-specific outcomes, ± definitions, meta-analysis inclusion tables, harms and durability materials are needed. Material additions and condition changes are recorded separately; no new research, calculation or regrading is executed. This records needed materials; no new research was executed."
    }
  ]
}