{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3013-s1",
  "verdict_number": "3013",
  "title": "Oral sucrose × Pain-specific neural responses—separate neonatal heel-lance trial",
  "view_version": "1.0",
  "view_created_date": "2026-10-21",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The question concerns neural responses during a separate neonatal heel-lance trial. Detailed age, term status, health, eligibility and stimulus conditions remain unverified. Vaccination-infant ages and eligibility are not transferred.",
    "intervention": "The oral-sucrose procedural-pain trial in Slater's citation is linked. There is no separate original evidence-summary entry, and preparation, concurrent sucking, holding and feeding details are unlinked.",
    "dose": "Exact concentration, volume, administration time, repetition and actual dose in the heel-lance neural trial remain unverified. Concentrations, volumes and pre-vaccination times from parent vaccination reports are not substituted.",
    "comparator": "The heel-lance neural trial's exact control, group care, pacifier use, holding, feeding and adherence remain unverified. Parent sterile-water, water, no-intervention and breastfeeding comparisons are not transferred.",
    "endpoint": "The selected question concerns pain-specific neural responses. The original note of a null prespecified EEG primary endpoint is distinguished from separate spinal reflexes and behavioral scores. Exact effects, units, denominators, P values, CIs and the exact direction of behavioral differences are unlinked.",
    "duration": "The heel-lance neural measurement window and observation period remain unverified. Vaccination behavioral-measurement times or long-term and repeated exposures are not substituted.",
    "excluded_extensions": [
      "Transferring positive vaccination behavior into reduced heel-lance neural responses or complete nociceptive blockade",
      "Copying vaccination concentrations, volumes, times, populations or denominators into the neural trial",
      "Converting a null prespecified EEG narrative into exact effect 0, equivalence or absence of individual pain",
      "Extending a limited record from another procedure to every sucrose exposure, concentration, procedure or long-term neurodevelopment",
      "Converting citations or shared reports into new unique counts, independent replication, grades or use instructions"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which neural response and procedure does the question concern?",
      "needed": "Boundary between selected neural responses, separate heel lance and vaccination behavior",
      "role": "Required",
      "role_reason": "Material on Boundary between selected neural responses, separate heel lance and vaccination behavior is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Boundary between selected neural responses, separate heel lance and vaccination behavior must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material on the same procedure, population, intervention and neural endpoint is needed. Reduced vaccination behavior is not converted into blocked neural responses or a new claim. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The selected question is reduced pain-specific neural responses. The original note describes a null prespecified EEG primary endpoint in a separate neonatal heel-lance trial.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Direct material on the same procedure, population, intervention and neural endpoint is needed. Reduced vaccination behavior is not converted into blocked neural responses or a new claim.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct material on the same procedure, population, intervention and neural endpoint is needed. Reduced vaccination behavior is not converted into blocked neural responses or a new claim."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How do selected D and parent C54 differ?",
      "needed": "Selected grade and absent individual score and axes",
      "role": "Required",
      "role_reason": "Material on Selected grade and absent individual score and axes is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected grade and absent individual score and axes must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Question-specific verdict and change histories are needed. Positive behavior or parent 54 points are not filled in as selected neural effects or scores, and D is not newly reassessed. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The selected neural-response item is D, with no individual score, status or axes. Parent C54 and separate vaccination-behavior C are distinguished.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Question-specific verdict and change histories are needed. Positive behavior or parent 54 points are not filled in as selected neural effects or scores, and D is not newly reassessed.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Question-specific verdict and change histories are needed. Positive behavior or parent 54 points are not filled in as selected neural effects or scores, and D is not newly reassessed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What material was actually read?",
      "needed": "Complete stored Korean and English accounts and a citation-only neural report",
      "role": "Required",
      "role_reason": "Material on Complete stored Korean and English accounts and a citation-only neural report is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Complete stored Korean and English accounts and a citation-only neural report must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original material and acquisition, access and reading histories are needed. Historical verification narratives in the original citation are not inherited as current full-text reading or completed content review. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The complete stored parent Korean and English accounts, 3 evidence summaries, 4 citations and subquestions were read. The neural report appears only in the bibliography; external papers, abstracts, registration and plans are unread.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original material and acquisition, access and reading histories are needed. Historical verification narratives in the original citation are not inherited as current full-text reading or completed content review.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original material and acquisition, access and reading histories are needed. Historical verification narratives in the original citation are not inherited as current full-text reading or completed content review."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What is Slater's neural-response report?",
      "needed": "Original neonatal heel-lance RCT bibliography and citation-only status",
      "role": "Required",
      "role_reason": "Material on Original neonatal heel-lance RCT bibliography and citation-only status is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original neonatal heel-lance RCT bibliography and citation-only status must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: The original paper, registration, EEG, spinal-reflex and behavioral material are needed. A citation alone does not fill a new evidence-summary entry, exact results or denominators. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Slater 2010 in Lancet, PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 are retained. There is no separate summary entry in the original evidence list.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "The original paper, registration, EEG, spinal-reflex and behavioral material are needed. A citation alone does not fill a new evidence-summary entry, exact results or denominators.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The original paper, registration, EEG, spinal-reflex and behavioral material are needed. A citation alone does not fill a new evidence-summary entry, exact results or denominators."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Do the vaccination reports directly answer the neural question?",
      "needed": "Vaccination behavior and crying versus neural endpoints",
      "role": "Required",
      "role_reason": "Material on Vaccination behavior and crying versus neural endpoints is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Vaccination behavior and crying versus neural endpoints must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material on the same procedure and neural endpoint is needed. Vaccination samples, concentrations and times are not copied into the neural trial or pooled as independent neural replication. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Hatfield 2008, Allen 1996 and Gad 2019 are linked as parent context concerning vaccination behavior, crying and FLACC.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Direct material on the same procedure and neural endpoint is needed. Vaccination samples, concentrations and times are not copied into the neural trial or pooled as independent neural replication.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct material on the same procedure and neural endpoint is needed. Vaccination samples, concentrations and times are not copied into the neural trial or pooled as independent neural replication."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are the same reports and participants counted more than once?",
      "needed": "Shared citations, separate procedures, report families and unique counts",
      "role": "Required",
      "role_reason": "Material on Shared citations, separate procedures, report families and unique counts is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Shared citations, separate procedures, report families and unique counts must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Trial, population, related-report and endpoint relationships are needed. The same report is not added as new independent trials or participants in both tables; unique and independent neural-trial totals remain unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The behavioral and neural questions share parent reports. Heel lance concerns a neonatal report involving a different procedure from vaccination.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Trial, population, related-report and endpoint relationships are needed. The same report is not added as new independent trials or participants in both tables; unique and independent neural-trial totals remain unverified.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial, population, related-report and endpoint relationships are needed. The same report is not added as new independent trials or participants in both tables; unique and independent neural-trial totals remain unverified."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What population and procedure did the neural trial study?",
      "needed": "Neonatal heel-lance age, term status, health, eligibility and stimulus",
      "role": "Required",
      "role_reason": "Material on Neonatal heel-lance age, term status, health, eligibility and stimulus is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neonatal heel-lance age, term status, health, eligibility and stimulus must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Detailed neural-trial age, eligibility, term status, health and stimulus procedure are needed. Vaccination populations and ages are not transferred to the neural trial. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original account distinguishes neural responses during neonatal heel lance from infant vaccination behavior.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Detailed neural-trial age, eligibility, term status, health and stimulus procedure are needed. Vaccination populations and ages are not transferred to the neural trial.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Detailed neural-trial age, eligibility, term status, health and stimulus procedure are needed. Vaccination populations and ages are not transferred to the neural trial."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are neural-trial concentration, volume and administration time known?",
      "needed": "Actual oral exposure and preparation in the heel-lance trial",
      "role": "Required",
      "role_reason": "Material on Actual oral exposure and preparation in the heel-lance trial is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Actual oral exposure and preparation in the heel-lance trial must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial preparation, concentration, volume, actual administration and adherence material are needed. Vaccination 24% plus pacifier, 12% 2mL and 2 minutes before vaccination are not filled in as this trial's exposure. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Slater's citation only identifies a randomized trial of oral sucrose for procedural pain. This preserved account provides no exact concentration, volume or timing.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Neural-trial preparation, concentration, volume, actual administration and adherence material are needed. Vaccination 24% plus pacifier, 12% 2mL and 2 minutes before vaccination are not filled in as this trial's exposure.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Neural-trial preparation, concentration, volume, actual administration and adherence material are needed. Vaccination 24% plus pacifier, 12% 2mL and 2 minutes before vaccination are not filled in as this trial's exposure."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the neural-trial control, pacifier and feeding conditions?",
      "needed": "Controls and group-specific concurrent exposure within the same heel-lance trial",
      "role": "Required",
      "role_reason": "Material on Controls and group-specific concurrent exposure within the same heel-lance trial is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Controls and group-specific concurrent exposure within the same heel-lance trial must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original neural-trial control, pacifier, holding, feeding, group care and adherence material are needed. Vaccination-control conditions are not substituted. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent's vaccination water, no-intervention and feeding comparisons are distinguished from the separate heel-lance neural question.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original neural-trial control, pacifier, holding, feeding, group care and adherence material are needed. Vaccination-control conditions are not substituted.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original neural-trial control, pacifier, holding, feeding, group care and adherence material are needed. Vaccination-control conditions are not substituted."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are EEG, spinal reflexes and behavior scores the same outcome?",
      "needed": "Pain-specific EEG primary endpoint versus separate reflex and behavioral measures",
      "role": "Required",
      "role_reason": "Material on Pain-specific EEG primary endpoint versus separate reflex and behavioral measures is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Pain-specific EEG primary endpoint versus separate reflex and behavioral measures must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: EEG, reflex and behavioral methods and endpoint-hierarchy tables are needed. Different outcomes are not pooled, and behavioral differences are not promoted into a positive neural primary endpoint. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original note and citation distinguish the null prespecified pain-specific EEG primary endpoint during heel lance from behavioral-score differences. The account also treats spinal reflexes as a separate physiological question.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "EEG, reflex and behavioral methods and endpoint-hierarchy tables are needed. Different outcomes are not pooled, and behavioral differences are not promoted into a positive neural primary endpoint.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "EEG, reflex and behavioral methods and endpoint-hierarchy tables are needed. Different outcomes are not pooled, and behavioral differences are not promoted into a positive neural primary endpoint."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What are the exact EEG effect and interval behind the null narrative?",
      "needed": "Neural effect, units, variability, P, CI, denominator and important difference",
      "role": "Required",
      "role_reason": "Material on Neural effect, units, variability, P, CI, denominator and important difference is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neural effect, units, variability, P, CI, denominator and important difference must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original EEG results, measurement windows, units, variability, denominators, P values, CIs and important differences are needed. The null narrative is not converted into exact effect 0, equivalence, a new interval or complete nociceptive blockade. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The preserved observation is a directional narrative that the prespecified EEG primary endpoint was null. Exact neural effects, denominators and original intervals are unlinked.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original EEG results, measurement windows, units, variability, denominators, P values, CIs and important differences are needed. The null narrative is not converted into exact effect 0, equivalence, a new interval or complete nociceptive blockade.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original EEG results, measurement windows, units, variability, denominators, P values, CIs and important differences are needed. The null narrative is not converted into exact effect 0, equivalence, a new interval or complete nociceptive blockade."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "How do behavioral differences during the same heel lance relate to neural results?",
      "needed": "Behavioral and EEG findings, times and denominators within the same procedure",
      "role": "Required",
      "role_reason": "Material on Behavioral and EEG findings, times and denominators within the same procedure is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Behavioral and EEG findings, times and denominators within the same procedure must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original behavioral and neural results, denominators and times within the same procedure are needed. Vaccination 7-minute means of 3.8 versus 4.8 are not substituted as heel-lance behavior scores. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original citation describes the null EEG primary endpoint separately from behavioral-score differences. Exact direction, size and denominators for heel-lance behavior are unlinked in this preserved account.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original behavioral and neural results, denominators and times within the same procedure are needed. Vaccination 7-minute means of 3.8 versus 4.8 are not substituted as heel-lance behavior scores.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original behavioral and neural results, denominators and times within the same procedure are needed. Vaccination 7-minute means of 3.8 versus 4.8 are not substituted as heel-lance behavior scores."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are neural-trial samples, denominators and losses known?",
      "needed": "Randomization, measurement, analysis and endpoint-specific missingness",
      "role": "Required",
      "role_reason": "Material on Randomization, measurement, analysis and endpoint-specific missingness is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Randomization, measurement, analysis and endpoint-specific missingness must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial flow, EEG-, reflex- and behavior-specific analysis denominators, missingness and sensitivity material are needed. Vaccination counts of 100, 83, 38, 45, 285 and 120 are not transferred, and neural events or totals are not newly calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The stored account provides no Slater neural-trial sample size, group denominators or loss table.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Neural-trial flow, EEG-, reflex- and behavior-specific analysis denominators, missingness and sensitivity material are needed. Vaccination counts of 100, 83, 38, 45, 285 and 120 are not transferred, and neural events or totals are not newly calculated.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Neural-trial flow, EEG-, reflex- and behavior-specific analysis denominators, missingness and sensitivity material are needed. Vaccination counts of 100, 83, 38, 45, 285 and 120 are not transferred, and neural events or totals are not newly calculated."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Were neural-trial allocation, blinding and analysis verified?",
      "needed": "Original allocation, concealment, assessment, baseline and neural analysis",
      "role": "Required",
      "role_reason": "Material on Original allocation, concealment, assessment, baseline and neural analysis is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original allocation, concealment, assessment, baseline and neural analysis must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original methods, baseline, analysis populations, adjustment, repeated measurements and EEG analysis models are needed. Vaccination-trial design descriptions are not inherited by this trial. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Slater's citation identifies a randomized controlled trial. Detailed allocation, concealment, blinding and analysis are unlinked.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original methods, baseline, analysis populations, adjustment, repeated measurements and EEG analysis models are needed. Vaccination-trial design descriptions are not inherited by this trial.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original methods, baseline, analysis populations, adjustment, repeated measurements and EEG analysis models are needed. Vaccination-trial design descriptions are not inherited by this trial."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What was verified about prespecified EEG, ISRCTN and plans?",
      "needed": "Original primary-endpoint narrative versus reading registration and plans",
      "role": "Required",
      "role_reason": "Material on Original primary-endpoint narrative versus reading registration and plans is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original primary-endpoint narrative versus reading registration and plans must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Registration changes, protocols, analysis plans and complete endpoints are needed. Identifiers or historical notes alone do not complete comparison of prespecified hierarchy, changes or analysis. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original note's null prespecified EEG primary endpoint and the citation's ISRCTN78390996 are retained. Current registration, protocol and analysis-plan material are unread.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Registration changes, protocols, analysis plans and complete endpoints are needed. Identifiers or historical notes alone do not complete comparison of prespecified hierarchy, changes or analysis.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registration changes, protocols, analysis plans and complete endpoints are needed. Identifiers or historical notes alone do not complete comparison of prespecified hierarchy, changes or analysis."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do vaccination water, pacifier and feeding findings replicate neural results?",
      "needed": "Different interventions, controls, procedures and behavioral endpoints",
      "role": "Required",
      "role_reason": "Material on Different interventions, controls, procedures and behavioral endpoints is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Different interventions, controls, procedures and behavioral endpoints must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural comparisons matching procedure, intervention and measurement are needed. Different behavioral findings are not pooled as independent positive or negative neural replication, and sucrose-specific nociceptive blockade is not created. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The positive vaccination sucrose-plus-pacifier finding, the nonspecific water comparison for 12% sucrose and breastfeeding superiority are separate behavioral comparisons.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Neural comparisons matching procedure, intervention and measurement are needed. Different behavioral findings are not pooled as independent positive or negative neural replication, and sucrose-specific nociceptive blockade is not created.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Neural comparisons matching procedure, intervention and measurement are needed. Different behavioral findings are not pooled as independent positive or negative neural replication, and sucrose-specific nociceptive blockade is not created."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What about other procedures, doses, repetition and long-term neural effects?",
      "needed": "Heel lance, vaccination, concentration, age, repetition and long-term applicability",
      "role": "Required",
      "role_reason": "Material on Heel lance, vaccination, concentration, age, repetition and long-term applicability is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Heel lance, vaccination, concentration, age, repetition and long-term applicability must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Material on the same procedure, exposure, repetition, long-term outcomes and prespecified subgroups is needed. A limited null narrative is not extended to every concentration, procedure or sucrose exposure, or to long-term neurodevelopment. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The stored account treats neonatal heel lance separately from infant vaccination.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Material on the same procedure, exposure, repetition, long-term outcomes and prespecified subgroups is needed. A limited null narrative is not extended to every concentration, procedure or sucrose exposure, or to long-term neurodevelopment.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Material on the same procedure, exposure, repetition, long-term outcomes and prespecified subgroups is needed. A limited null narrative is not extended to every concentration, procedure or sucrose exposure, or to long-term neurodevelopment."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Does this establish blocked neural nociception or complete pain elimination?",
      "needed": "Selected EEG, reflexes and behavior versus individual pain",
      "role": "Required",
      "role_reason": "Material on Selected EEG, reflexes and behavior versus individual pain is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected EEG, reflexes and behavior versus individual pain must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material linking selected neural endpoints and clinical analgesia is needed. Null EEG is not converted into absence of an individual's pain or absolute inefficacy, and positive behavior does not establish reduced neural responses. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04",
        "S01",
        "S02",
        "S03"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The stored account distinguishes behavioral calming from blocked neural nociception and complete elimination of vaccine pain.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Direct material linking selected neural endpoints and clinical analgesia is needed. Null EEG is not converted into absence of an individual's pain or absolute inefficacy, and positive behavior does not establish reduced neural responses.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct material linking selected neural endpoints and clinical analgesia is needed. Null EEG is not converted into absence of an individual's pain or absolute inefficacy, and positive behavior does not establish reduced neural responses."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What funded the neural trial, supplied products and declared COI?",
      "needed": "Neural-report funding, products, employment, patents and interests",
      "role": "Required",
      "role_reason": "Material on Neural-report funding, products, employment, patents and interests is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neural-report funding, products, employment, patents and interests must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original neural-trial funding, product support, author employment, patent and COI disclosures are needed. Vaccination-report support indexing, no-manufacturer-involvement narratives or parent I2 are not transferred as verified independence for this trial. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Slater's citation provides no funding, product or COI specifications.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Original neural-trial funding, product support, author employment, patent and COI disclosures are needed. Vaccination-report support indexing, no-manufacturer-involvement narratives or parent I2 are not transferred as verified independence for this trial.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original neural-trial funding, product support, author employment, patent and COI disclosures are needed. Vaccination-report support indexing, no-manufacturer-involvement narratives or parent I2 are not transferred as verified independence for this trial."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are neural-trial harm collection and exposure denominators known?",
      "needed": "Events, aspiration, withdrawal, exposure, time and controls",
      "role": "Supplementary",
      "role_reason": "Material on Events, aspiration, withdrawal, exposure, time and controls is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Events, aspiration, withdrawal, exposure, time and controls must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial group events, collection, withdrawals, exposure denominators, periods and controls are needed. Null neural findings or behavioral differences are not judged as safety or absence of harms. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The parent's clinician, small-amount and specified-concentration context and aspiration and repeated-use cautions are retained as original context.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Neural-trial group events, collection, withdrawals, exposure denominators, periods and controls are needed. Null neural findings or behavioral differences are not judged as safety or absence of harms.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Neural-trial group events, collection, withdrawals, exposure denominators, periods and controls are needed. Null neural findings or behavioral differences are not judged as safety or absence of harms."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What about concurrent exposure, baseline risks, repeated use and long-term harms?",
      "needed": "Sucking, feeding, procedure, timing and rare harms",
      "role": "Supplementary",
      "role_reason": "Material on Sucking, feeding, procedure, timing and rare harms is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Sucking, feeding, procedure, timing and rare harms must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Group exposure, baseline risks, concurrent care, withdrawal, recovery, repeated and long-term event material are needed. Specific harm causality, comparative risks, new incidence rates or absence of rare harms is not established. This records needed materials; no new research was executed.",
      "current_reports": [
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "The original safety-caution scope is retained. This table creates no new use, administration or individual-care instructions for improvised concentrations or repeated use.",
      "condition_status": "Unverified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Group exposure, baseline risks, concurrent care, withdrawal, recovery, repeated and long-term event material are needed. Specific harm causality, comparative risks, new incidence rates or absence of rare harms is not established.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Group exposure, baseline risks, concurrent care, withdrawal, recovery, repeated and long-term event material are needed. Specific harm causality, comparative risks, new incidence rates or absence of rare harms is not established."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What records do the selected and parent grades, languages, axes and dates represent?",
      "needed": "Selected D versus parent C54, original bilingual records and evidence date",
      "role": "Required",
      "role_reason": "Material on Selected D versus parent C54, original bilingual records and evidence date is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected D versus parent C54, original bilingual records and evidence date must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Question-specific verdicts, changes and additional material are needed. Parent effect, endpoint, replication and independence axes and historical cross-checks are not inherited as new selected neural-response axes, certification or completed review. This records needed materials; no new research was executed.",
      "current_reports": [
        "S01",
        "S02",
        "S03",
        "S04"
      ],
      "existence": "Displayed selected and parent records exist in the stored summary. External availability, acquisition, content and reading of detailed materials remain separately unverified.",
      "acquired_read": "Complete stored parent Korean and English summary, selected question and bibliography read; external abstracts, full text, registration, protocols and analysis plans unread",
      "observation": "Selected D and absent individual score, status and axes, parent C54, original Korean and English accounts, axes and evidence date 2026-09-07 are retained. The original correction list and separate deliberation record are empty.",
      "condition_status": "Partly verified",
      "status_reason": "This state links partial information and gaps in the preserved selected and parent accounts. External verification and clinical content review remain incomplete; it does not certify fulfilled conditions, efficacy, safety, prespecification or independence.",
      "missingness": "Question-specific verdicts, changes and additional material are needed. Parent effect, endpoint, replication and independence axes and historical cross-checks are not inherited as new selected neural-response axes, certification or completed review.",
      "uncertainty": "Target effects, endpoint-specific denominators, measurement, prespecified hierarchy, bias, externally validated important differences, durability, harms, independence and overlap remain unverified. Original numbers, historical verification narratives and registration identifiers are not promoted into new calculations, completed content review or clinical certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Question-specific verdicts, changes and additional material are needed. Parent effect, endpoint, replication and independence axes and historical cross-checks are not inherited as new selected neural-response axes, certification or completed review."
    }
  ],
  "reports": [
    {
      "report_id": "S01",
      "title": "Hatfield LA et al. 2008",
      "url": "https://pubmed.ncbi.nlm.nih.gov/18245406/",
      "report_type": "Randomized vaccination trial of sucrose plus pacifier versus sterile water",
      "existence": "Stored bibliographic link exists; external identity, availability, acquisition and reading remain unverified",
      "acquired_read": "The complete stored parent Korean and English accounts and bibliography were read. External papers, registration, protocols, analysis plans and support disclosures are unread.",
      "study_family": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "independent_replication": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "observed_result": "100 infants randomized and 83 analyzed, 38 versus 45. Behavioral-pain scores with 24% sucrose plus a pacifier were lower at 5, 7 and 9 minutes; 7-minute means were 3.8 versus 4.8. The account's 17 analysis exclusions are also retained.",
      "result_level": "These are stored composite-intervention findings. Original group allocation, exclusion reasons, time-specific variability, denominators and original CIs remain unverified. They are not promoted into sucrose-only contribution, complete nociceptive blockade or current independence certification. This is parent vaccination-behavior context and is not transferred as direct effects or denominators for the selected heel-lance neural response.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "External paper",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Funding, product support and COI material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID18245406, DOI10.1542/peds.2006-3719 and NCT00150189 are linked to the original bibliography. The empty original registration field is distinguished from the citation identifier; registration, plans and full text are unread. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/18245406/"
        }
      ]
    },
    {
      "report_id": "S02",
      "title": "Allen KD et al. 1996",
      "url": "https://pubmed.ncbi.nlm.nih.gov/8603220/",
      "report_type": "Double-blind randomized vaccination trial of sucrose, water and no intervention",
      "existence": "Stored bibliographic link exists; external identity, availability, acquisition and reading remain unverified",
      "acquired_read": "The complete stored parent Korean and English accounts and bibliography were read. External papers, registration, protocols, analysis plans and support disclosures are unread.",
      "study_family": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "independent_replication": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "observed_result": "285 infants aged 2 weeks to 18 months. The original account reports that 12% sucrose 2mL and water both reduced crying versus no intervention at 2 weeks, without a sucrose-specific effect.",
      "result_level": "These are stored findings specific to age, concentration and controls. They are not converted into effect 0 at every age or precise equivalence with water. Unverified funding and COI, and the pre-registration-era narrative, are not promoted into current searches or certification. This is parent vaccination-behavior context and is not transferred as direct effects or denominators for the selected heel-lance neural response.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "External paper",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Funding, product support and COI material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID8603220 and DOI10.1001/archpedi.1996.02170280040007 are retained. The pre-registration-era account is an original narrative; empty registration fields are not replaced with a new number, search or not-applicable judgment. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/8603220/"
        }
      ]
    },
    {
      "report_id": "S03",
      "title": "Gad RF et al. 2019",
      "url": "https://pubmed.ncbi.nlm.nih.gov/30807328/",
      "report_type": "3-arm randomized vaccination trial of sucrose, breastfeeding and control",
      "existence": "Stored bibliographic link exists; external identity, availability, acquisition and reading remain unverified",
      "acquired_read": "The complete stored parent Korean and English accounts and bibliography were read. External papers, registration, protocols, analysis plans and support disclosures are unread.",
      "study_family": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "independent_replication": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "observed_result": "The stored account reports that breastfeeding was superior to sucrose and control for pain and crying in a trial of 120 infants, with P<.001.",
      "result_level": "FLACC, crying time and heart rate are the original endpoint list. Individual heart-rate findings, group denominators, exact effects and CIs remain unverified. Breastfeeding superiority is not transferred to sucrose-only effects or reduced neural responses. This is parent vaccination-behavior context and is not transferred as direct effects or denominators for the selected heel-lance neural response.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "External paper",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Funding, product support and COI material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID30807328 and DOI10.1097/NMC.0000000000000512 are retained. Unverified registration, funding and COI and the unblinded flag are retained without promotion into current independence or efficacy certification. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/30807328/"
        }
      ]
    },
    {
      "report_id": "S04",
      "title": "Slater R et al. 2010",
      "url": "https://pubmed.ncbi.nlm.nih.gov/20817247/",
      "report_type": "Citation-only randomized trial during separate neonatal heel lance",
      "existence": "Stored bibliographic link exists; external identity, availability, acquisition and reading remain unverified",
      "acquired_read": "The complete stored parent Korean and English accounts and bibliography were read. External papers, registration, protocols, analysis plans and support disclosures are unread.",
      "study_family": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "independent_replication": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified.",
      "observed_result": "The parent account distinguishes the null prespecified pain-specific EEG primary endpoint during separate heel lance from behavioral-score differences and spinal reflexes. There is no separate entry in the stored evidence-summary list.",
      "result_level": "This is a citation-only record relevant to the selected neural question. The original note's null prespecified EEG narrative is retained, but exact neural effects, P values, CIs, samples, measurement windows and the exact direction and size of behavioral differences are unlinked. A null narrative is not promoted into exact effect 0 or equivalence, and vaccination conditions or denominators are not filled in.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "External paper",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Statistical analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        },
        {
          "material_type": "Funding, product support and COI material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "PMID20817247, DOI10.1016/S0140-6736(10)61303-7 and ISRCTN78390996 appear in the original citation. The citation-only neural report and empty original registration field are retained. The original prespecified EEG narrative does not establish current registration or plan reading, or creation of a new evidence-summary entry. The material-level 2026-09-07 date is the stored account's historical evidence date. Dates originally displayed even for unread external materials are retained without conversion into external acquisition, access or reading dates, or current completed-review dates."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/20817247/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The selected neural-response question and the vaccination-behavior and crying question share parent reports. Slater's separate neonatal heel-lance citation is distinguished from vaccination reports by procedure, intervention, endpoints and denominators. Report slots and family links are not added into new unique trial, participant or independent neural-replication counts; those totals remain unverified."
  },
  "history": [
    {
      "date": "2026-10-21",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public-facing views and materials were prepared from the existing 22 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-21"
}