{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Oral sucrose × Pain-specific neural responses—separate neonatal heel-lance trial",
  "language": "en",
  "translation_date": "2026-10-21",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which neural response and procedure does the question concern?",
      "needed": "Boundary between selected neural responses, separate heel lance and vaccination behavior",
      "role": "Required",
      "role_reason": "Material on Boundary between selected neural responses, separate heel lance and vaccination behavior is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Boundary between selected neural responses, separate heel lance and vaccination behavior must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material on the same procedure, population, intervention and neural endpoint is needed. Reduced vaccination behavior is not converted into blocked neural responses or a new claim. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How do selected D and parent C54 differ?",
      "needed": "Selected grade and absent individual score and axes",
      "role": "Required",
      "role_reason": "Material on Selected grade and absent individual score and axes is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected grade and absent individual score and axes must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Question-specific verdict and change histories are needed. Positive behavior or parent 54 points are not filled in as selected neural effects or scores, and D is not newly reassessed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What material was actually read?",
      "needed": "Complete stored Korean and English accounts and a citation-only neural report",
      "role": "Required",
      "role_reason": "Material on Complete stored Korean and English accounts and a citation-only neural report is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Complete stored Korean and English accounts and a citation-only neural report must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original material and acquisition, access and reading histories are needed. Historical verification narratives in the original citation are not inherited as current full-text reading or completed content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What is Slater's neural-response report?",
      "needed": "Original neonatal heel-lance RCT bibliography and citation-only status",
      "role": "Required",
      "role_reason": "Material on Original neonatal heel-lance RCT bibliography and citation-only status is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original neonatal heel-lance RCT bibliography and citation-only status must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: The original paper, registration, EEG, spinal-reflex and behavioral material are needed. A citation alone does not fill a new evidence-summary entry, exact results or denominators. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Do the vaccination reports directly answer the neural question?",
      "needed": "Vaccination behavior and crying versus neural endpoints",
      "role": "Required",
      "role_reason": "Material on Vaccination behavior and crying versus neural endpoints is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Vaccination behavior and crying versus neural endpoints must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material on the same procedure and neural endpoint is needed. Vaccination samples, concentrations and times are not copied into the neural trial or pooled as independent neural replication. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are the same reports and participants counted more than once?",
      "needed": "Shared citations, separate procedures, report families and unique counts",
      "role": "Required",
      "role_reason": "Material on Shared citations, separate procedures, report families and unique counts is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Shared citations, separate procedures, report families and unique counts must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Trial, population, related-report and endpoint relationships are needed. The same report is not added as new independent trials or participants in both tables; unique and independent neural-trial totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What population and procedure did the neural trial study?",
      "needed": "Neonatal heel-lance age, term status, health, eligibility and stimulus",
      "role": "Required",
      "role_reason": "Material on Neonatal heel-lance age, term status, health, eligibility and stimulus is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neonatal heel-lance age, term status, health, eligibility and stimulus must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Detailed neural-trial age, eligibility, term status, health and stimulus procedure are needed. Vaccination populations and ages are not transferred to the neural trial. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Are neural-trial concentration, volume and administration time known?",
      "needed": "Actual oral exposure and preparation in the heel-lance trial",
      "role": "Required",
      "role_reason": "Material on Actual oral exposure and preparation in the heel-lance trial is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Actual oral exposure and preparation in the heel-lance trial must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial preparation, concentration, volume, actual administration and adherence material are needed. Vaccination 24% plus pacifier, 12% 2mL and 2 minutes before vaccination are not filled in as this trial's exposure. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What were the neural-trial control, pacifier and feeding conditions?",
      "needed": "Controls and group-specific concurrent exposure within the same heel-lance trial",
      "role": "Required",
      "role_reason": "Material on Controls and group-specific concurrent exposure within the same heel-lance trial is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Controls and group-specific concurrent exposure within the same heel-lance trial must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original neural-trial control, pacifier, holding, feeding, group care and adherence material are needed. Vaccination-control conditions are not substituted. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are EEG, spinal reflexes and behavior scores the same outcome?",
      "needed": "Pain-specific EEG primary endpoint versus separate reflex and behavioral measures",
      "role": "Required",
      "role_reason": "Material on Pain-specific EEG primary endpoint versus separate reflex and behavioral measures is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Pain-specific EEG primary endpoint versus separate reflex and behavioral measures must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: EEG, reflex and behavioral methods and endpoint-hierarchy tables are needed. Different outcomes are not pooled, and behavioral differences are not promoted into a positive neural primary endpoint. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What are the exact EEG effect and interval behind the null narrative?",
      "needed": "Neural effect, units, variability, P, CI, denominator and important difference",
      "role": "Required",
      "role_reason": "Material on Neural effect, units, variability, P, CI, denominator and important difference is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neural effect, units, variability, P, CI, denominator and important difference must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original EEG results, measurement windows, units, variability, denominators, P values, CIs and important differences are needed. The null narrative is not converted into exact effect 0, equivalence, a new interval or complete nociceptive blockade. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "How do behavioral differences during the same heel lance relate to neural results?",
      "needed": "Behavioral and EEG findings, times and denominators within the same procedure",
      "role": "Required",
      "role_reason": "Material on Behavioral and EEG findings, times and denominators within the same procedure is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Behavioral and EEG findings, times and denominators within the same procedure must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original behavioral and neural results, denominators and times within the same procedure are needed. Vaccination 7-minute means of 3.8 versus 4.8 are not substituted as heel-lance behavior scores. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are neural-trial samples, denominators and losses known?",
      "needed": "Randomization, measurement, analysis and endpoint-specific missingness",
      "role": "Required",
      "role_reason": "Material on Randomization, measurement, analysis and endpoint-specific missingness is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Randomization, measurement, analysis and endpoint-specific missingness must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial flow, EEG-, reflex- and behavior-specific analysis denominators, missingness and sensitivity material are needed. Vaccination counts of 100, 83, 38, 45, 285 and 120 are not transferred, and neural events or totals are not newly calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Were neural-trial allocation, blinding and analysis verified?",
      "needed": "Original allocation, concealment, assessment, baseline and neural analysis",
      "role": "Required",
      "role_reason": "Material on Original allocation, concealment, assessment, baseline and neural analysis is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original allocation, concealment, assessment, baseline and neural analysis must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original methods, baseline, analysis populations, adjustment, repeated measurements and EEG analysis models are needed. Vaccination-trial design descriptions are not inherited by this trial. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What was verified about prespecified EEG, ISRCTN and plans?",
      "needed": "Original primary-endpoint narrative versus reading registration and plans",
      "role": "Required",
      "role_reason": "Material on Original primary-endpoint narrative versus reading registration and plans is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Original primary-endpoint narrative versus reading registration and plans must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Registration changes, protocols, analysis plans and complete endpoints are needed. Identifiers or historical notes alone do not complete comparison of prespecified hierarchy, changes or analysis. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do vaccination water, pacifier and feeding findings replicate neural results?",
      "needed": "Different interventions, controls, procedures and behavioral endpoints",
      "role": "Required",
      "role_reason": "Material on Different interventions, controls, procedures and behavioral endpoints is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Different interventions, controls, procedures and behavioral endpoints must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural comparisons matching procedure, intervention and measurement are needed. Different behavioral findings are not pooled as independent positive or negative neural replication, and sucrose-specific nociceptive blockade is not created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What about other procedures, doses, repetition and long-term neural effects?",
      "needed": "Heel lance, vaccination, concentration, age, repetition and long-term applicability",
      "role": "Required",
      "role_reason": "Material on Heel lance, vaccination, concentration, age, repetition and long-term applicability is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Heel lance, vaccination, concentration, age, repetition and long-term applicability must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Material on the same procedure, exposure, repetition, long-term outcomes and prespecified subgroups is needed. A limited null narrative is not extended to every concentration, procedure or sucrose exposure, or to long-term neurodevelopment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Does this establish blocked neural nociception or complete pain elimination?",
      "needed": "Selected EEG, reflexes and behavior versus individual pain",
      "role": "Required",
      "role_reason": "Material on Selected EEG, reflexes and behavior versus individual pain is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected EEG, reflexes and behavior versus individual pain must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Direct material linking selected neural endpoints and clinical analgesia is needed. Null EEG is not converted into absence of an individual's pain or absolute inefficacy, and positive behavior does not establish reduced neural responses. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What funded the neural trial, supplied products and declared COI?",
      "needed": "Neural-report funding, products, employment, patents and interests",
      "role": "Required",
      "role_reason": "Material on Neural-report funding, products, employment, patents and interests is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Neural-report funding, products, employment, patents and interests must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Original neural-trial funding, product support, author employment, patent and COI disclosures are needed. Vaccination-report support indexing, no-manufacturer-involvement narratives or parent I2 are not transferred as verified independence for this trial. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are neural-trial harm collection and exposure denominators known?",
      "needed": "Events, aspiration, withdrawal, exposure, time and controls",
      "role": "Supplementary",
      "role_reason": "Material on Events, aspiration, withdrawal, exposure, time and controls is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Events, aspiration, withdrawal, exposure, time and controls must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Neural-trial group events, collection, withdrawals, exposure denominators, periods and controls are needed. Null neural findings or behavioral differences are not judged as safety or absence of harms. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What about concurrent exposure, baseline risks, repeated use and long-term harms?",
      "needed": "Sucking, feeding, procedure, timing and rare harms",
      "role": "Supplementary",
      "role_reason": "Material on Sucking, feeding, procedure, timing and rare harms is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Sucking, feeding, procedure, timing and rare harms must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Group exposure, baseline risks, concurrent care, withdrawal, recovery, repeated and long-term event material are needed. Specific harm causality, comparative risks, new incidence rates or absence of rare harms is not established. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What records do the selected and parent grades, languages, axes and dates represent?",
      "needed": "Selected D versus parent C54, original bilingual records and evidence date",
      "role": "Required",
      "role_reason": "Material on Selected D versus parent C54, original bilingual records and evidence date is needed to connect the selected heel-lance neural-response question with procedure, population, exposure, controls, measurement, denominators, precision and harm boundaries.",
      "application_exception": "Selected D and absent individual score, status and axes are retained, distinguishing vaccination-behavior C and parent C54. Heel-lance EEG, spinal reflexes and behavior are not mixed with vaccination interventions, controls, doses or denominators. No new effect, CI, precise effect 0, equivalence, unique total, grade, administration or individual-care guidance is created.",
      "criterion": "Original material on Selected D versus parent C54, original bilingual records and evidence date must link to the same procedure, neural endpoint, comparator, measurement window and denominators, distinguishing vaccination behavior, parent context and unread external material.",
      "basis": "Preserved principles distinguishing questions, direct comparisons, reports and trials, endpoints, denominators, precision and harms informed production.",
      "condition_origin": "These are evidence conditions for the existing pain-specific neural-response question. They do not establish preregistration, execution of an official tool or completed clinical content review.",
      "proposed_research": "Material needed: Question-specific verdicts, changes and additional material are needed. Parent effect, endpoint, replication and independence axes and historical cross-checks are not inherited as new selected neural-response axes, certification or completed review. This records needed materials; no new research was executed."
    }
  ]
}