{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3009-s1",
  "verdict_number": "3009",
  "title": "Ginger dry extract × Migraine—evidence sheet on reduced severe-pain days, acute analgesic use, or attack duration",
  "view_version": "1.0",
  "view_created_date": "2026-10-20",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The stored account concerns a placebo-controlled trial of 107 adults with episodic migraine. Overall size is not transferred into arm-specific analysis counts or attack, diary or harms denominators for individual pain outcomes. Diagnosis, baseline severity, concurrent care, eligibility and arm-specific characteristics are unverified.",
    "intervention": "The original intervention is single-ingredient oral ginger dry extract standardized to 5% active constituents. This is not converted into a specific gingerol content or equivalence with culinary ginger, acute combination products or other formulations. Product, constituent markers, manufacturing, batch and placebo details are unverified.",
    "dose": "The original study schedule of dry extract 200 mg, 3 times daily for 3 months is preserved. Total daily or active-constituent amounts are not calculated or converted into personal dosing or an optimal dose. Actual exposure, adherence and product-specific quantitative details are unverified.",
    "comparator": "The direct control is placebo. Within-arm improvement is distinguished from added ginger benefit over placebo. Placebo composition, blinding, concurrent or changed preventive and acute medications, and matching of care remain unverified.",
    "endpoint": "The selection is reduced severe-pain days, acute analgesic use, or attack duration. Original subclaim D and the explanation of within-arm changes without between-arm advantage are retained. The parent responder outcome is not transferred as the same effect or denominator; individual definitions, units, effects, CIs and analysis details are unverified.",
    "duration": "The trial concerns 3-month single-ingredient prevention, distinguished from acute-attack treatment. Baseline, visit, attack and measurement windows for each outcome, post-treatment persistence and long-term or rare harms are unverified. Observation duration is not extended into an exact harms timeline or verification of long-term effects.",
    "excluded_extensions": [
      "Do not convert within-arm improvement into added ginger benefit over placebo.",
      "Do not transfer the parent 50% responder threshold or denominator to pain days, analgesic use or duration.",
      "Do not add sharing across the same report, outcomes, parent and subclaims as new independent trial, participant or event totals.",
      "Do not combine acute feverfew combinations, sumatriptan controls or nausea signals as replication of the same single-ingredient prevention question.",
      "Do not create new total daily or active-constituent amounts, medication discontinuation, replacement, dosing or treatment guidance."
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What is the selected pain-related question?",
      "needed": "Original question covering severe-pain days, acute analgesic use and attack duration",
      "role": "Required",
      "role_reason": "This condition links Original question covering severe-pain days, acute analgesic use and attack duration with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Original question covering severe-pain days, acute analgesic use and attack duration must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original wording and change records linking the selection with its parent prevention context are needed. Explaining outcomes separately does not make them new independent trials. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The selection is reduced severe-pain days, acute analgesic use, or attack duration. Outcomes are distinguished within the existing subclaim without creating new trials or separate independent questions.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original wording and change records linking the selection with its parent prevention context are needed. Explaining outcomes separately does not make them new independent trials.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original wording and change records linking the selection with its parent prevention context are needed. Explaining outcomes separately does not make them new independent trials."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How do selected D and parent D30 differ?",
      "needed": "Distinction between question-specific grades, scores, status and original explanations",
      "role": "Required",
      "role_reason": "This condition links Distinction between question-specific grades, scores, status and original explanations with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between question-specific grades, scores, status and original explanations must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Separate score, status and axes are absent from the selection. Original selected and parent records must be preserved, with their scopes distinguished if an authorized correction occurs. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original explanation for selected D is that within-group changes occurred without a between-group advantage. Parent D30 concerns attack prevention and responder outcomes and is not transferred as the selected question's score.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Separate score, status and axes are absent from the selection. Original selected and parent records must be preserved, with their scopes distinguished if an authorized correction occurs.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Separate score, status and axes are absent from the selection. Original selected and parent records must be preserved, with their scopes distinguished if an authorized correction occurs."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Which ginger dry extract do these findings concern?",
      "needed": "Single-ingredient oral extract, active-constituent standardization and product conditions",
      "role": "Required",
      "role_reason": "This condition links Single-ingredient oral extract, active-constituent standardization and product conditions with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Single-ingredient oral extract, active-constituent standardization and product conditions must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original constituent markers, quantities, manufacturing, excipients, raw materials and quality records are needed. Direct effects are not transferred merely because products share a name. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The account concerns ginger dry extract standardized to 5% active constituents. It is distinguished from culinary ginger and combination products without converting this into a specific gingerol content or equivalence across all ginger products.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original constituent markers, quantities, manufacturing, excipients, raw materials and quality records are needed. Direct effects are not transferred merely because products share a name.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original constituent markers, quantities, manufacturing, excipients, raw materials and quality records are needed. Direct effects are not transferred merely because products share a name."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "What does 200 mg, 3 times daily for 3 months describe?",
      "needed": "Original trial exposure schedule, adherence, discontinuation and measurement timing",
      "role": "Required",
      "role_reason": "This condition links Original trial exposure schedule, adherence, discontinuation and measurement timing with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Original trial exposure schedule, adherence, discontinuation and measurement timing must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original records linking actual administration, adherence, discontinuation and changes to visit-specific outcome denominators are needed. Scheduled and actual exposure are not treated as identical. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The preserved condition is dry extract 200 mg, 3 times daily for 3 months. It is not converted into new dosing instructions or an optimal dose, and total daily or active amounts are not calculated.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original records linking actual administration, adherence, discontinuation and changes to visit-specific outcome denominators are needed. Scheduled and actual exposure are not treated as identical.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original records linking actual administration, adherence, discontinuation and changes to visit-specific outcome denominators are needed. Scheduled and actual exposure are not treated as identical."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Which adults with episodic migraine were studied?",
      "needed": "Diagnosis, baseline severity, eligibility and concurrent care",
      "role": "Required",
      "role_reason": "This condition links Diagnosis, baseline severity, eligibility and concurrent care with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Diagnosis, baseline severity, eligibility and concurrent care must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original eligibility, diagnosis, baseline attacks and pain, preventive and acute medication, exclusions and arm-specific distributions are needed. Applicability is not extended to other patient groups. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The account concerns a placebo-controlled trial of 107 adults with episodic migraine. Overall size alone does not verify arm-specific characteristics or analysis denominators for the selected outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original eligibility, diagnosis, baseline attacks and pain, preventive and acute medication, exclusions and arm-specific distributions are needed. Applicability is not extended to other patient groups.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original eligibility, diagnosis, baseline attacks and pain, preventive and acute medication, exclusions and arm-specific distributions are needed. Applicability is not extended to other patient groups."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What placebo provided the direct comparison?",
      "needed": "Placebo composition, blinding, background care and direct between-arm comparisons",
      "role": "Required",
      "role_reason": "This condition links Placebo composition, blinding, background care and direct between-arm comparisons with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Placebo composition, blinding, background care and direct between-arm comparisons must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Placebo ingredients, appearance and sensory matching, arm-specific concurrent care, adherence and contrast plans are needed. Design labels alone do not verify procedural details. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original design is a double-blind placebo-controlled randomized trial. Interpretation distinguishes direct comparison with placebo from changes in the ginger arm alone.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Placebo ingredients, appearance and sensory matching, arm-specific concurrent care, adherence and contrast plans are needed. Design labels alone do not verify procedural details.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Placebo ingredients, appearance and sensory matching, arm-specific concurrent care, adherence and contrast plans are needed. Design labels alone do not verify procedural details."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are 3-month prevention and acute-attack treatment the same question?",
      "needed": "Distinction between outcomes within prevention, acute treatment and post-treatment persistence",
      "role": "Required",
      "role_reason": "This condition links Distinction between outcomes within prevention, acute treatment and post-treatment persistence with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between outcomes within prevention, acute treatment and post-treatment persistence must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Baseline observation, visits, attack definitions, diaries and outcome-specific measurement windows are needed. Post-treatment persistence and contributions from acute treatment require separate information. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original trial concerns 3-month prevention. Acute analgesic use and attack duration are outcomes within that prevention trial and are not converted into a claim that ginger immediately treats pain.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Baseline observation, visits, attack definitions, diaries and outcome-specific measurement windows are needed. Post-treatment persistence and contributions from acute treatment require separate information.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Baseline observation, visits, attack definitions, diaries and outcome-specific measurement windows are needed. Post-treatment persistence and contributions from acute treatment require separate information."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "How were the three outcomes measured and expressed?",
      "needed": "Definitions and aggregation of severe-pain days, acute medication use and attack duration",
      "role": "Required",
      "role_reason": "This condition links Definitions and aggregation of severe-pain days, acute medication use and attack duration with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Definitions and aggregation of severe-pain days, acute medication use and attack duration must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: The severe-pain threshold, aggregation of days, attacks and medication use, time units, recorders, timing and individual denominators are needed. Outcome names in the summary do not establish measurement details. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The selection and preserved endpoint list distinguish severe-pain days, analgesic use and duration. Different measurements are not combined into one effect estimate or a shared denominator.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "The severe-pain threshold, aggregation of days, attacks and medication use, time units, recorders, timing and individual denominators are needed. Outcome names in the summary do not establish measurement details.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The severe-pain threshold, aggregation of days, attacks and medication use, time units, recorders, timing and individual denominators are needed. Outcome names in the summary do not establish measurement details."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What is the original finding for severe-pain days?",
      "needed": "Direct between-arm estimate, interval, units and denominator for severe-pain days",
      "role": "Required",
      "role_reason": "This condition links Direct between-arm estimate, interval, units and denominator for severe-pain days with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Direct between-arm estimate, interval, units and denominator for severe-pain days must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original result tables specifying pain-day definitions, aggregation, denominators, adjustment and exact effects, CIs and P values are needed. Missing values are not filled using another outcome's numbers. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The preserved account reports no significant between-arm difference in severe-pain days. This is not converted into absence of painful days or proof of an exact zero effect or equivalence.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original result tables specifying pain-day definitions, aggregation, denominators, adjustment and exact effects, CIs and P values are needed. Missing values are not filled using another outcome's numbers.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original result tables specifying pain-day definitions, aggregation, denominators, adjustment and exact effects, CIs and P values are needed. Missing values are not filled using another outcome's numbers."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What is the original finding for acute analgesic use?",
      "needed": "Acute medication types, use aggregation and direct comparison with placebo",
      "role": "Required",
      "role_reason": "This condition links Acute medication types, use aggregation and direct comparison with placebo with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Acute medication types, use aggregation and direct comparison with placebo must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Medication types, rescue rules, quantities and frequency, background-medication changes, denominators, exact effects and intervals are needed. No new tapering or treatment guidance is created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The account also reports no between-arm difference in acute analgesic use. This is not converted into medication discontinuation, replacement or direct acute analgesic efficacy of ginger.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Medication types, rescue rules, quantities and frequency, background-medication changes, denominators, exact effects and intervals are needed. No new tapering or treatment guidance is created.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Medication types, rescue rules, quantities and frequency, background-medication changes, denominators, exact effects and intervals are needed. No new tapering or treatment guidance is created."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "What is the original finding for attack duration?",
      "needed": "Attack onset, ending, time aggregation and between-arm estimation",
      "role": "Required",
      "role_reason": "This condition links Attack onset, ending, time aggregation and between-arm estimation with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Attack onset, ending, time aggregation and between-arm estimation must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original attack diaries, onset and ending definitions, time units, duplicate aggregation, acute-medication effects, models, denominators and CIs are needed. Exact durations or effects are not newly calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The preserved account also reports no between-arm difference in attack duration. This is not extended to identical responses in all attacks or individuals, or a definitive absence of immediate effects.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original attack diaries, onset and ending definitions, time units, duplicate aggregation, acute-medication effects, models, denominators and CIs are needed. Exact durations or effects are not newly calculated.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original attack diaries, onset and ending definitions, time units, duplicate aggregation, acute-medication effects, models, denominators and CIs are needed. Exact durations or effects are not newly calculated."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Is the 50% responder outcome the same as the selected pain outcomes?",
      "needed": "Distinction between the parent responder outcome and pain days, medication use and duration",
      "role": "Required",
      "role_reason": "This condition links Distinction between the parent responder outcome and pain days, medication use and duration with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between the parent responder outcome and pain days, medication use and duration must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Prespecified plans, hierarchy, full result tables, denominators and analyses for each outcome are needed. The responder criterion is not used as a clinical threshold for other outcomes. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The proportion with at least a 50% reduction in attacks belongs to the parent prevention context and another subclaim. It is not transferred as the same measure or denominator for pain days, analgesic use or duration.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Prespecified plans, hierarchy, full result tables, denominators and analyses for each outcome are needed. The responder criterion is not used as a clinical threshold for other outcomes.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Prespecified plans, hierarchy, full result tables, denominators and analyses for each outcome are needed. The responder criterion is not used as a clinical threshold for other outcomes."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "How should changes over time in both arms be interpreted?",
      "needed": "Distinction between within-arm changes and direct effects versus placebo",
      "role": "Required",
      "role_reason": "This condition links Distinction between within-arm changes and direct effects versus placebo with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between within-arm changes and direct effects versus placebo must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Baseline, final and time-specific values, direct between-arm contrasts, adjustment models, intervals and denominators are needed. Within-arm changes are not subtracted to create a new effect. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original selected explanation states that within-arm changes occurred without a between-arm advantage. Improvement in both arms is not converted into an added ginger benefit over placebo.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Baseline, final and time-specific values, direct between-arm contrasts, adjustment models, intervals and denominators are needed. Within-arm changes are not subtracted to create a new effect.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Baseline, final and time-specific values, direct between-arm contrasts, adjustment models, intervals and denominators are needed. Within-arm changes are not subtracted to create a new effect."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Does no between-arm difference prove an exact zero effect?",
      "needed": "Distinction between effect magnitude, exact intervals, precision and importance",
      "role": "Required",
      "role_reason": "This condition links Distinction between effect magnitude, exact intervals, precision and importance with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between effect magnitude, exact intervals, precision and importance must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Exact point estimates, CIs, variance, denominators, models and clinical importance thresholds for each outcome are needed. No new CIs, effects, grades or equivalence judgments are created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original counterview explains that exact intervals are insufficient to assign F and completely exclude a small benefit. Between-arm nonsignificance is not converted into an exact zero effect or equivalence.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Exact point estimates, CIs, variance, denominators, models and clinical importance thresholds for each outcome are needed. No new CIs, effects, grades or equivalence judgments are created.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Exact point estimates, CIs, variance, denominators, models and clinical importance thresholds for each outcome are needed. No new CIs, effects, grades or equivalence judgments are created."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What denominator does the figure of 107 adults describe?",
      "needed": "Overall randomized size versus arm, outcome, attack and diary analysis denominators",
      "role": "Required",
      "role_reason": "This condition links Overall randomized size versus arm, outcome, attack and diary analysis denominators with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Overall randomized size versus arm, outcome, attack and diary analysis denominators must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Flow diagrams, arm-specific allocation, completion, exclusions, outcome denominators, diary and attack units and observation time are needed. New participant or event totals are not calculated. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original 107 adults describe the overall randomization context. This is not directly used as each arm's or pain outcome's valid analysis count, attack or diary count, or harms denominator.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Flow diagrams, arm-specific allocation, completion, exclusions, outcome denominators, diary and attack units and observation time are needed. New participant or event totals are not calculated.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Flow diagrams, arm-specific allocation, completion, exclusions, outcome denominators, diary and attack units and observation time are needed. New participant or event totals are not calculated."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do randomized and double-blind labels verify the procedures?",
      "needed": "Details of allocation, concealment, blinding and outcome measurement",
      "role": "Required",
      "role_reason": "This condition links Details of allocation, concealment, blinding and outcome measurement with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Details of allocation, concealment, blinding and outcome measurement must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Sequence generation, concealment, blinded parties and maintenance, assessors, baseline balance and measurement procedures are needed. External originals are not labeled as read. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original randomized and double-blind design labels are retained. Design strengths described in parent materials are not converted into a new formal bias assessment or completed content review.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Sequence generation, concealment, blinded parties and maintenance, assessors, baseline balance and measurement procedures are needed. External originals are not labeled as read.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Sequence generation, concealment, blinded parties and maintenance, assessors, baseline balance and measurement procedures are needed. External originals are not labeled as read."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Are the selected outcomes' prespecified hierarchy and analyses verified?",
      "needed": "Outcome hierarchy and changes in registration, protocols and analysis plans",
      "role": "Required",
      "role_reason": "This condition links Outcome hierarchy and changes in registration, protocols and analysis plans with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Outcome hierarchy and changes in registration, protocols and analysis plans must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original registration history, protocols, analysis plans, plan timing, changes and multiplicity handling are needed. Current materials are not used as certification of preregistration. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original endpoint list includes responder and pain-related outcomes together. Lists or labels in parent materials do not establish the prespecified hierarchy of primary, secondary or co-primary outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original registration history, protocols, analysis plans, plan timing, changes and multiplicity handling are needed. Current materials are not used as certification of preregistration.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration history, protocols, analysis plans, plan timing, changes and multiplicity handling are needed. Current materials are not used as certification of preregistration."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Who measured the outcomes, using which diaries and instruments?",
      "needed": "Recording, validation and measurement windows for pain, medication use and duration",
      "role": "Required",
      "role_reason": "This condition links Recording, validation and measurement windows for pain, medication use and duration with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Recording, validation and measurement windows for pain, medication use and duration must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original diaries, scales, recorders, assessor blinding, record validation, missing entries and time-window records are needed. Measurement procedures unverified within the preserved scope remain unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The stored summary names the pain-related outcomes but does not provide recording-instrument or aggregation details. This is not treated as proof of nonreporting in the entire paper or measurement failure.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original diaries, scales, recorders, assessor blinding, record validation, missing entries and time-window records are needed. Measurement procedures unverified within the preserved scope remain unverified.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original diaries, scales, recorders, assessor blinding, record validation, missing entries and time-window records are needed. Measurement procedures unverified within the preserved scope remain unverified."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are adherence, deviations and background medication distinguished from ginger's contribution?",
      "needed": "Actual exposure, preventive and acute medications, changes and analysis targets",
      "role": "Required",
      "role_reason": "This condition links Actual exposure, preventive and acute medications, changes and analysis targets with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Actual exposure, preventive and acute medications, changes and analysis targets must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Administration, concurrent care, changes, discontinuation, crossover, arm-specific records and analysis plans are needed. Changes in concurrent care are not attributed solely to ginger itself. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Prevention-trial assignment is distinguished from the acute-medication-use outcome. The stored summary alone does not establish actual arm-specific adherence, background medication, additional care or their effects.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Administration, concurrent care, changes, discontinuation, crossover, arm-specific records and analysis plans are needed. Changes in concurrent care are not attributed solely to ginger itself.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Administration, concurrent care, changes, discontinuation, crossover, arm-specific records and analysis plans are needed. Changes in concurrent care are not attributed solely to ginger itself."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Which outcomes and records were missing from analysis?",
      "needed": "Missing data and follow-up loss by arm, outcome, attack and diary",
      "role": "Required",
      "role_reason": "This condition links Missing data and follow-up loss by arm, outcome, attack and diary with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Missing data and follow-up loss by arm, outcome, attack and diary must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Dropout, exclusions, record-validity criteria, arm-specific missingness, adjustments and sensitivity analyses are needed. Absence of missing data or analysis of every participant is not assumed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Overall randomized size is not used as every outcome's valid denominator. Missingness and handling for individual pain outcomes, attacks and diaries are unverified in the stored summary.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Dropout, exclusions, record-validity criteria, arm-specific missingness, adjustments and sensitivity analyses are needed. Absence of missing data or analysis of every participant is not assumed.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Dropout, exclusions, record-validity criteria, arm-specific missingness, adjustments and sensitivity analyses are needed. Absence of missing data or analysis of every participant is not assumed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Which effect was estimated for each outcome?",
      "needed": "Analysis populations, units, direct contrasts, adjustment and repeated measurements",
      "role": "Required",
      "role_reason": "This condition links Analysis populations, units, direct contrasts, adjustment and repeated measurements with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Analysis populations, units, direct contrasts, adjustment and repeated measurements must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: ITT and PP distinctions, baseline adjustment, repeated-attack and measurement models, exact estimates, CIs and denominators are needed. Different analysis levels are not combined as the same result. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original account of no core between-arm differences is preserved. Analysis populations, target effects and models for pain days, analgesic use and duration are not newly estimated.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "ITT and PP distinctions, baseline adjustment, repeated-attack and measurement models, exact estimates, CIs and denominators are needed. Different analysis levels are not combined as the same result.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "ITT and PP distinctions, baseline adjustment, repeated-attack and measurement models, exact estimates, CIs and denominators are needed. Different analysis levels are not combined as the same result."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Is the clinical importance of the pain outcomes established?",
      "needed": "Units, importance thresholds and patient-important changes for each measure",
      "role": "Required",
      "role_reason": "This condition links Units, importance thresholds and patient-important changes for each measure with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Units, importance thresholds and patient-important changes for each measure must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Measurement evidence, thresholds, distributions, intervals and patient-importance information for each outcome are needed. Arbitrary importance boundaries or individual applications are not created. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The account describes insufficient exact CIs and external clinical importance thresholds. Overall nonsignificance alone does not establish an individual's benefit or absence of an important effect.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Measurement evidence, thresholds, distributions, intervals and patient-importance information for each outcome are needed. Arbitrary importance boundaries or individual applications are not created.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Measurement evidence, thresholds, distributions, intervals and patient-importance information for each outcome are needed. Arbitrary importance boundaries or individual applications are not created."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Can 3-month findings be applied to longer periods, other populations or doses?",
      "needed": "Scope of trial duration, population, dose and post-treatment persistence",
      "role": "Required",
      "role_reason": "This condition links Scope of trial duration, population, dose and post-treatment persistence with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Scope of trial duration, population, dose and post-treatment persistence must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Post-treatment follow-up, direct comparisons, original exposure and prespecified subgroup and interaction information are needed. Persistence or effects in other populations are not newly established. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original scope is 3-month single-ingredient prevention in episodic migraine. Culinary ginger, other formulations and periods, acute treatment or post hoc subgroups are not automatically included.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Post-treatment follow-up, direct comparisons, original exposure and prespecified subgroup and interaction information are needed. Persistence or effects in other populations are not newly established.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Post-treatment follow-up, direct comparisons, original exposure and prespecified subgroup and interaction information are needed. Persistence or effects in other populations are not newly established."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Are no between-arm differences and within-arm changes both preserved?",
      "needed": "Complete results, within-arm changes, direct comparisons and precision gaps",
      "role": "Required",
      "role_reason": "This condition links Complete results, within-arm changes, direct comparisons and precision gaps with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Complete results, within-arm changes, direct comparisons and precision gaps must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Complete original result tables, outcome and report lists, exact estimates and intervals are needed. No new conflict judgment is created without establishing the scope of conflicting or additional reports. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original lack of core between-arm differences and the selected explanation's within-arm changes are retained together. Improvement in both arms is not converted into an added ginger benefit, and unfavorable findings are not removed.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Complete original result tables, outcome and report lists, exact estimates and intervals are needed. No new conflict judgment is created without establishing the scope of conflicting or additional reports.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Complete original result tables, outcome and report lists, exact estimates and intervals are needed. No new conflict judgment is created without establishing the scope of conflicting or additional reports."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are shared reports and outcomes counted as independent trials?",
      "needed": "Links between the same report, trial, cohort and selected or parent outcomes",
      "role": "Required",
      "role_reason": "This condition links Links between the same report, trial, cohort and selected or parent outcomes with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Links between the same report, trial, cohort and selected or parent outcomes must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original registration, recruitment, related reports and family links between outcomes and analyses are needed. Unique trial, participant, attack and event totals remain unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The preserved evidence and bibliography concern the same Martins 2020 prevention report. The original sole-direct-prevention-trial statement is retained, while reused outcomes and parent materials are not added as independent replication.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original registration, recruitment, related reports and family links between outcomes and analyses are needed. Unique trial, participant, attack and event totals remain unverified.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration, recruitment, related reports and family links between outcomes and analyses are needed. Unique trial, participant, attack and event totals remain unverified."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Do acute combination and active-control studies replicate the same prevention question?",
      "needed": "Distinction between feverfew combinations, sumatriptan controls and single-ingredient prevention",
      "role": "Required",
      "role_reason": "This condition links Distinction between feverfew combinations, sumatriptan controls and single-ingredient prevention with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between feverfew combinations, sumatriptan controls and single-ingredient prevention must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Authorized existing originals and information on intervention, population, comparator, period and outcome relevance are needed. Bibliographies, effects or independent-replication counts absent from the original account are not created. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The account did not count acute feverfew–ginger combinations or sumatriptan active controls as replication of 3-month single-ingredient ginger prevention. Nausea or other symptom findings are not transferred as the same outcomes either.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Authorized existing originals and information on intervention, population, comparator, period and outcome relevance are needed. Bibliographies, effects or independent-replication counts absent from the original account are not created.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Authorized existing originals and information on intervention, population, comparator, period and outcome relevance are needed. Bibliographies, effects or independent-replication counts absent from the original account are not created."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What does the identifier NCT02570633 establish?",
      "needed": "Distinction between the registration string, registration content and prespecification",
      "role": "Required",
      "role_reason": "This condition links Distinction between the registration string, registration content and prespecification with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between the registration string, registration content and prespecification must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original registration history, protocols, analysis plans and links to reports are needed. Registration URLs are not guessed and unread content is not labeled as verified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "NCT02570633 is preserved in the original evidence and bibliography. Presence of the string is not converted into current reading of registration originals, identity verification or confirmation of prespecified analysis.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original registration history, protocols, analysis plans and links to reports are needed. Registration URLs are not guessed and unread content is not labeled as verified.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration history, protocols, analysis plans and links to reports are needed. Registration URLs are not guessed and unread content is not labeled as verified."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What do manufacturer independence and full-text support checking describe?",
      "needed": "Distinction between historical support-checking statements and current reading or role verification",
      "role": "Required",
      "role_reason": "This condition links Distinction between historical support-checking statements and current reading or role verification with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between historical support-checking statements and current reading or role verification must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original funding, COI and roles in finance, product provision, authorship, analysis and publication are needed. Historical checking statements are not inherited as completed current external comparison. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The parent account describes manufacturer independence and checking support details in the original text, retaining full-text checking language in English. These are historical records, not current full-text reading or new certification of independence.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original funding, COI and roles in finance, product provision, authorship, analysis and publication are needed. Historical checking statements are not inherited as completed current external comparison.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original funding, COI and roles in finance, product provision, authorship, analysis and publication are needed. Historical checking statements are not inherited as completed current external comparison."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Which materials were actually read and which are needed?",
      "needed": "Distinction between stored summaries, external abstracts, full texts, registration and needed materials",
      "role": "Required",
      "role_reason": "This condition links Distinction between stored summaries, external abstracts, full texts, registration and needed materials with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between stored summaries, external abstracts, full texts, registration and needed materials must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Authorized originals, individual result tables, diaries, registration and plans are needed. Links or needed-material entries are not converted into acquisition, full-text reading or access failure. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The linked content was transferred from the stored parent summary and selected question. External abstracts, full texts, registration, plans, diaries and support materials are unread, with access not attempted.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Authorized originals, individual result tables, diaries, registration and plans are needed. Links or needed-material entries are not converted into acquisition, full-text reading or access failure.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Authorized originals, individual result tables, diaries, registration and plans are needed. Links or needed-material entries are not converted into acquisition, full-text reading or access failure."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "How do the original evidence date and this production date differ?",
      "needed": "Preserved evidence date, historical checking, corrections and production timing",
      "role": "Required",
      "role_reason": "This condition links Preserved evidence date, historical checking, corrections and production timing with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Preserved evidence date, historical checking, corrections and production timing must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Actual historical access locations, timing, search scope and original correction records are needed. Evidence dates, condition-authoring dates and view-production dates are preserved as separate roles. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original evidence date is 2026-09-07 and the correction list is empty. Historical cross-checking or verification language is not converted into a current external-reading or completed-content-review date.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Actual historical access locations, timing, search scope and original correction records are needed. Evidence dates, condition-authoring dates and view-production dates are preserved as separate roles.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual historical access locations, timing, search scope and original correction records are needed. Evidence dates, condition-authoring dates and view-production dates are preserved as separate roles."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Are the selected Korean and English wording and parent context retained?",
      "needed": "Original wording, grade and explanation for pain outcomes versus parent prevention context",
      "role": "Required",
      "role_reason": "This condition links Original wording, grade and explanation for pain outcomes versus parent prevention context with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Original wording, grade and explanation for pain outcomes versus parent prevention context must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: The original selected and parent wording in both languages must be linked to authorized correction records. Scores or status absent from the selection are not created during translation. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The selected Korean and English wording lists severe-pain days, acute analgesic use and attack duration, preserving within-arm changes without between-arm advantage. Parent prevention and responder conditions are not automatically applied to the selected outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "The original selected and parent wording in both languages must be linked to authorized correction records. Scores or status absent from the selection are not created during translation.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The original selected and parent wording in both languages must be linked to authorized correction records. Scores or status absent from the selection are not created during translation."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "Do parent axes and empty fields certify review of the selected outcomes?",
      "needed": "Parent axes and flags versus absence of a separate selected-question assessment",
      "role": "Required",
      "role_reason": "This condition links Parent axes and flags versus absence of a separate selected-question assessment with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Parent axes and flags versus absence of a separate selected-question assessment must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: The applicable question for each original field and authorized change records must be distinguished. Numbers or empty fields are not used as new certification of independence, precision or safety. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Parent B/P/R1/I2/E0/B1/C0, false flags and empty correction or deliberation fields are preserved in the original. These are not converted into new selected-outcome scores, axes, formal assessments or completed content review.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "The applicable question for each original field and authorized change records must be distinguished. Numbers or empty fields are not used as new certification of independence, precision or safety.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The applicable question for each original field and authorized change records must be distinguished. Numbers or empty fields are not used as new certification of independence, precision or safety."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "What harm information concerns heartburn and abdominal discomfort?",
      "needed": "General cautions versus direct event data for the selected product",
      "role": "Required",
      "role_reason": "This condition links General cautions versus direct event data for the selected product with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for General cautions versus direct event data for the selected product must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original adverse-event definitions, collection, severity, arm-specific people and events, exposure and denominators are needed. Reporting gaps are not labeled as absence of events or safety. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The original safety account mentions possible heartburn and abdominal discomfort with ginger supplements. This is not treated as an available trial-specific event table, and general cautions are not converted into new incidence estimates.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original adverse-event definitions, collection, severity, arm-specific people and events, exposure and denominators are needed. Reporting gaps are not labeled as absence of events or safety.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original adverse-event definitions, collection, severity, arm-specific people and events, exposure and denominators are needed. Reporting gaps are not labeled as absence of events or safety."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Are harm onset, discontinuation and recovery times known?",
      "needed": "Timing of exposure, event onset, recovery and re-exposure",
      "role": "Required",
      "role_reason": "This condition links Timing of exposure, event onset, recovery and re-exposure with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Timing of exposure, event onset, recovery and re-exposure must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original records of exposure, onset, latency, discontinuation, recovery, re-exposure and observation periods are needed. Missing timing information does not establish absence of harm. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The 3-month prevention-effect observation period is not converted into an exact timeline of harm onset or recovery. Arm-specific harms follow-up and timing relationships are unverified in the stored summary.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original records of exposure, onset, latency, discontinuation, recovery, re-exposure and observation periods are needed. Missing timing information does not establish absence of harm.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original records of exposure, onset, latency, discontinuation, recovery, re-exposure and observation periods are needed. Missing timing information does not establish absence of harm."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "Can harm frequency and comparative risk be established?",
      "needed": "Denominators for exposed people, events, time and direct comparisons",
      "role": "Required",
      "role_reason": "This condition links Denominators for exposed people, events, time and direct comparisons with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Denominators for exposed people, events, time and direct comparisons must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Arm-specific events, people, duplication, exposure, observation time, collection methods, direct comparisons and CIs are needed. Risk numbers are not created from material without denominators. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The overall 107 adults and lack of core between-arm differences do not establish a harms analysis denominator or absence of events. General cautions are not calculated into incidence or comparative risks.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Arm-specific events, people, duplication, exposure, observation time, collection methods, direct comparisons and CIs are needed. Risk numbers are not created from material without denominators.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Arm-specific events, people, duplication, exposure, observation time, collection methods, direct comparisons and CIs are needed. Risk numbers are not created from material without denominators."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "What is the scope of anticoagulant, antiplatelet, bleeding and surgery cautions?",
      "needed": "Existing concurrent-medication and baseline-risk cautions versus direct interaction data",
      "role": "Required",
      "role_reason": "This condition links Existing concurrent-medication and baseline-risk cautions versus direct interaction data with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Existing concurrent-medication and baseline-risk cautions versus direct interaction data must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Concurrent medication, baseline risk, alternative causes, direct events and long-term, rare-harm and special-population information are needed. New medication changes or discontinuation instructions are not proposed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Original cautions concerning anticoagulants, antiplatelets, bleeding risk and surgery are retained. They are not converted into new interaction magnitudes, causal conclusions or treatment guidance for the selected population.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Concurrent medication, baseline risk, alternative causes, direct events and long-term, rare-harm and special-population information are needed. New medication changes or discontinuation instructions are not proposed.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Concurrent medication, baseline risk, alternative causes, direct events and long-term, rare-harm and special-population information are needed. New medication changes or discontinuation instructions are not proposed."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Can missing reports and repeated citations be counted as independent harm events?",
      "needed": "Harms collection, follow-up loss, unique people and events, and report families",
      "role": "Required",
      "role_reason": "This condition links Harms collection, follow-up loss, unique people and events, and report families with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Harms collection, follow-up loss, unique people and events, and report families must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Original collection, detection, reporting, follow-up loss and family links between related reports are needed. Repeated citations are not added as events, and missing reporting is not converted into absence of events. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Sharing across parent and subclaims or Korean and English accounts does not create new independent events. The stored summary lacks a list establishing unique original events and report families.",
      "condition_status": "Unverified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Original collection, detection, reporting, follow-up loss and family links between related reports are needed. Repeated citations are not added as events, and missing reporting is not converted into absence of events.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original collection, detection, reporting, follow-up loss and family links between related reports are needed. Repeated citations are not added as events, and missing reporting is not converted into absence of events."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "How far do the original null findings and evidence gaps extend?",
      "needed": "Between-arm nonsignificance, within-arm changes, precision and interpretation for each outcome",
      "role": "Required",
      "role_reason": "This condition links Between-arm nonsignificance, within-arm changes, precision and interpretation for each outcome with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Between-arm nonsignificance, within-arm changes, precision and interpretation for each outcome must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: Individual effects, CIs, clinical importance thresholds, denominators, prespecified plans, long-term and harms information are needed. Limits of findings, precision and individual applicability must be distinguished. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "The explanation for selected D and the parent's direct prevention findings are preserved. They are not extended into verification of exact zero effects, an F grade, acute-treatment efficacy or overall safety.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "Individual effects, CIs, clinical importance thresholds, denominators, prespecified plans, long-term and harms information are needed. Limits of findings, precision and individual applicability must be distinguished.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Individual effects, CIs, clinical importance thresholds, denominators, prespecified plans, long-term and harms information are needed. Limits of findings, precision and individual applicability must be distinguished."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "Do preserved methodological and condition links establish completed content review?",
      "needed": "Distinction between methodological records, condition production and clinical content review",
      "role": "Required",
      "role_reason": "This condition links Distinction between methodological records, condition production and clinical content review with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Distinction between methodological records, condition production and clinical content review must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: The source, scope and incomplete-review state of each condition must be retained. Technical view and file checks do not substitute for clinical content approval or a new judgment. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "Preserved methodology, condition templates and contracts are records linked for production. Their connection is not labeled as external-original reading, a new formal assessment or completed clinical content review.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "The source, scope and incomplete-review state of each condition must be retained. Technical view and file checks do not substitute for clinical content approval or a new judgment.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "The source, scope and incomplete-review state of each condition must be retained. Technical view and file checks do not substitute for clinical content approval or a new judgment."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "Which incoming materials would update the gaps?",
      "needed": "Outcome-specific definitions, denominators, effects, plans, families and change records",
      "role": "Required",
      "role_reason": "This condition links Outcome-specific definitions, denominators, effects, plans, families and change records with populations, interventions, controls, measurement, denominators, analyses, support and harms for the selected pain-day, analgesic-use and duration outcomes.",
      "application_exception": "Retain selected D and absent individual score, status and axes without inheriting parent D30. Distinguish pain days, analgesic use, duration and parent responder outcomes, within-arm and between-arm comparisons, single-ingredient prevention and acute combinations. No new effects, CIs, denominators, independent totals, grades, dosing or treatment instructions are created.",
      "criterion": "Original material for Outcome-specific definitions, denominators, effects, plans, families and change records must be linked to each outcome definition, unit, denominator, time point and between-arm contrast, distinguishing stored summaries, unread external material, within-arm changes, parent responder outcomes and acute-treatment questions.",
      "basis": "Preserved application criteria were used to distinguish questions, comparisons, reports and trials, outcomes, denominators and harms.",
      "condition_origin": "These conditions apply to the existing subclaim. They do not establish preregistration, official assessment or completed content review.",
      "proposed_research": "Material needed: When authorized original results, diaries, plans, family information or corrections arrive, the complete prior version must be preserved. Evidence additions, condition changes and judgment changes are distinguished while retaining each outcome's boundaries. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Displayed information exists in the stored parent summary. Public availability, acquisition and actual reading of external detailed materials remain separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols and analysis plans unread",
      "observation": "This production transfers original D, lack of between-arm differences, within-arm changes and precision gaps. Recording needed materials is not converted into new research or completed content review.",
      "condition_status": "Partly verified",
      "status_reason": "This information was transferred from the stored summary with the selected question distinguished from parent materials. Detailed originals and review of existing content remain incomplete; it does not establish clinical certification or review approval.",
      "missingness": "When authorized original results, diaries, plans, family information or corrections arrive, the complete prior version must be preserved. Evidence additions, condition changes and judgment changes are distinguished while retaining each outcome's boundaries.",
      "uncertainty": "Original within-arm changes, lack of between-arm differences and precision gaps are retained. Measurement, diaries, arm-specific denominators, effects, CIs, prespecified hierarchy, missingness, concurrent care and harms details for each outcome are unverified. Historical full-text checking or single-trial statements are not converted into completed current review, exact zero effects, equivalence or safety certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "When authorized original results, diaries, plans, family information or corrections arrive, the complete prior version must be preserved. Evidence additions, condition changes and judgment changes are distinguished while retaining each outcome's boundaries."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Martins LB et al. 2020",
      "url": "https://pubmed.ncbi.nlm.nih.gov/31398997/",
      "report_type": "Stored report of a single-ingredient ginger prevention trial; pain outcomes distinguished from parent responder findings",
      "existence": "The stored summary contains original report and bibliography records. Needed-material entries are not converted into acquisition or reading of external originals, or separate independent studies.",
      "acquired_read": "Complete stored parent summary and selected question read; external originals, diaries, registration, plans and support materials unread",
      "study_family": "Original report shared across parent, responder and pain outcomes; unique trial, participant and event totals unverified",
      "independent_replication": "The original Martins prevention report is shared across parent, responder and pain-related outcomes. The 107 adults and original sole-direct-prevention-trial statement retain separate contexts; outcomes do not add new independent replication, participants or events. Unique trial, participant and event totals are unverified.",
      "observed_result": "No significant between-group difference in the core outcomes",
      "result_level": "In the 3-month prevention trial of 107 adults, no between-arm differences in severe-pain days, acute analgesic use or attack duration are preserved alongside within-arm changes. Individual definitions, denominators, direct estimates, CIs, diaries, prespecified hierarchy and concurrent-care details are unverified. Parent scores and historical support checking are separate contexts.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "Analysis plans, diaries and denominators",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "Product, exposure and harms",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        },
        {
          "material_type": "Funding and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07 (original account date; not an external-reading date)",
          "qualification": "Preserve original PMID31398997, DOI10.1177/0333102419869319 and NCT02570633. Manufacturer independence and full-text support checking are historical statements, not completed current comparison of full text, registration, product provision, analysis or publication roles. Dates preserved on each material entry belong to the original account, not external acquisition, access or reading. External materials remain unread with access unattempted; no completed-content-review date is created in this work."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/31398997/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "The original Martins prevention report is shared across parent, responder and pain-related outcomes. The 107 adults and original sole-direct-prevention-trial statement retain separate contexts; outcomes do not add new independent replication, participants or events. Unique trial, participant and event totals are unverified."
  },
  "history": [
    {
      "date": "2026-10-20",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public-facing views and materials were prepared from the existing 40 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-20"
}