# Dilute sodium-hypochlorite baths added to standard care × Improved clinician-rated atopic-dermatitis severity Verdict 3008 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-19 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: The stored materials concern moderate-to-severe atopic dermatitis. Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are kept in their respective contexts. Trial-specific age, diagnosis, severity, eligibility and outcome-specific denominators are unverified; no new participant total is created. - Ingredient, formulation and route: The intervention is dilute sodium-hypochlorite bathing added to standard care. Continued emollients and topical treatment are distinguished from simultaneous antibiotic changes in some trials. Trial-specific products, concentrations, ingredients, quality and actual exposure are unverified; no new dilution, treatment or procedural instructions are created. - Dose: Hon's schedule of 2 times per week and 4 weeks per period is preserved as a study record. A formulation name is not a quantitative dose; final concentrations, products, actual exposure and adherence details are unverified. This schedule is not converted into personal-use instructions or an optimal dose. - Comparator: Hon's same-water control is distinguished from usual-care comparisons in the stored narrative. Original materials are needed to map shared bathing, contact, emollients, topical treatment and antibiotic changes. Common improvement is not converted into an ingredient-specific added effect, and different controls are not combined as the same comparison. - Measured outcome: The selection is improved clinician-rated atopic-dermatitis severity, retaining original subclaim C and absent individual score, status and axes. Hon's SCORAD, affected area and topical medication outcomes are distinguished from the review's EASI and EASI-50. A small pooled signal and a null water-controlled trial are both preserved without transferring effects to patient reports, colonization or infection or issuing new efficacy or equivalence judgments. - Duration: Hon's 4-week crossover periods are separated from the parent narrative of a more favorable 8-week trial. Exact links to the 8-week report, arms and outcomes and information on washout, carryover and long-term persistence are unverified. The Wong bibliography alone does not fill duration-specific findings, and short-term results are not extended into long-term efficacy or safety. - Questions outside this scope: SCORAD, affected area, EASI, EASI-50, patient reports, colonization and clinical infection are not merged into one outcome.; Original arm direction, denominators, timing and Bayesian credible intervals are retained; no new effects, differences or totals are calculated.; Wong's citation-only summary and Bakaa's meta-analysis evidence are distinguished; original trials, reports and review populations are not double counted.; Same-water controls and usual care are distinguished, and improvement under shared treatment is not converted into an effect of the bleach ingredient alone.; Original subclaim C and parent C50 context are retained without creating new concentrations, dilution methods, procedural or treatment guidance, or safety certification. ## Checklist items ### N01 · What are the selected clinician-rated severity question and the parent verdict? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The selection concerns improved clinician-rated atopic-dermatitis severity, with original subclaim C. Its explanation retains a small pooled EASI signal alongside a null water-controlled trial. Parent C50 is contextual. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values. - Required materials and conditions: Original subclaim C, explanation and parent-verdict context - Materials to obtain first: The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values. - Further research: Material needed: The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Original subclaim C, explanation and parent-verdict context must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Original subclaim C, explanation and parent-verdict context with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S03 ### N02 · Which atopic-dermatitis populations were studied? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The parent question concerns moderate-to-severe atopic dermatitis. The Hon bibliography describes childhood-onset moderate-to-severe eczema. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review. - Required materials and conditions: Trial-specific age, diagnosis, baseline severity and eligibility - Materials to obtain first: Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review. - Further research: Material needed: Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Trial-specific age, diagnosis, baseline severity and eligibility must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Trial-specific age, diagnosis, baseline severity and eligibility with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N03 · Were the products and formulations of the dilute baths specified? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The intervention is dilute sodium-hypochlorite bathing added to standard care. The stored account explains that concentrations and product formulations are not interchangeable. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions. - Required materials and conditions: Products, ingredients, final concentrations and trial-specific formulations - Materials to obtain first: Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions. - Further research: Material needed: Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Products, ingredients, final concentrations and trial-specific formulations must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Products, ingredients, final concentrations and trial-specific formulations with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N04 · Were same-water bathing and usual-care comparisons distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon is a direct crossover comparison against water bathing. The stored account lists comparisons against water or usual care. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath. - Required materials and conditions: Water controls, usual care and shared bathing conditions - Materials to obtain first: Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath. - Further research: Material needed: Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Water controls, usual care and shared bathing conditions must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Water controls, usual care and shared bathing conditions with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S03 ### N05 · Were shared effects of emollients and topical care distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account states that emollients and topical care continued and that standard treatment was not withdrawn. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone. - Required materials and conditions: Concurrent care, changes, medication use and adherence - Materials to obtain first: Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone. - Further research: Material needed: Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Concurrent care, changes, medication use and adherence must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Concurrent care, changes, medication use and adherence with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N06 · Which reports link to simultaneous antibiotic changes? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account separates simultaneous antibiotic changes in some trials from bleach-only effects. The Wong bibliography contains a summary of an Asian trial with concurrent treatment. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong. - Required materials and conditions: Antibiotic changes, arms, timing and effect attribution - Materials to obtain first: Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong. - Further research: Material needed: Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Antibiotic changes, arms, timing and effect attribution must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Antibiotic changes, arms, timing and effect attribution with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S02, S03 ### N07 · What is known about randomization and masking in Hon? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon is preserved as a double-blind randomized crossover trial of bleach versus water. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles. - Required materials and conditions: Sequence allocation, concealment, masking and assessment roles - Materials to obtain first: Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles. - Further research: Material needed: Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Sequence allocation, concealment, masking and assessment roles must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Sequence allocation, concealment, masking and assessment roles with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N08 · Were periods and carryover effects distinguished in Hon? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account retains the study schedule of 2 times per week and 4 weeks per period. This is a study record rather than personal-use guidance. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models. - Required materials and conditions: Periods, washout, sequence effects and analysis models - Materials to obtain first: Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models. - Further research: Material needed: Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Periods, washout, sequence effects and analysis models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Periods, washout, sequence effects and analysis models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N09 · How were completers and nonadherent participants recorded? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The preserved evidence states 40 completed and 14 nonadherent. The narrative describes a 40-person crossover trial. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated. - Required materials and conditions: Recruitment, allocation, completion, adherence and analysis denominators - Materials to obtain first: Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated. - Further research: Material needed: Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Recruitment, allocation, completion, adherence and analysis denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Recruitment, allocation, completion, adherence and analysis denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N10 · Were the null ITT result and adherence analyses distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon is preserved as finding no added bleach benefit by ITT. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed. - Required materials and conditions: Analysis populations, missing-data handling, ITT and PP - Materials to obtain first: Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed. - Further research: Material needed: Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Analysis populations, missing-data handling, ITT and PP must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Analysis populations, missing-data handling, ITT and PP with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N11 · Were SCORAD, affected-area and topical-medication findings distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon lists SCORAD, affected area and topical medication use as outcomes. These are not merged into one outcome or converted into EASI. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy. - Required materials and conditions: Outcomes, measures, assessors, timing and hierarchy - Materials to obtain first: Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy. - Further research: Material needed: Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Outcomes, measures, assessors, timing and hierarchy must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Outcomes, measures, assessors, timing and hierarchy with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N12 · What are the figures for the water-favoring affected-area result? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Affected-area SCORAD change is preserved as water -5.7±15.4 versus bleach 0.6±12.4, P=.03. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated. - Required materials and conditions: Arm-specific changes, dispersion notation, P value and denominators - Materials to obtain first: Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated. - Further research: Material needed: Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Arm-specific changes, dispersion notation, P value and denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Arm-specific changes, dispersion notation, P value and denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N13 · Were overall added benefit and individual findings distinguished in Hon? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored summary retains both no added bleach benefit by ITT and a water-favoring affected-area result. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding. - Required materials and conditions: Overall findings, component findings, multiplicity and estimates - Materials to obtain first: Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding. - Further research: Material needed: Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Overall findings, component findings, multiplicity and estimates must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Overall findings, component findings, multiplicity and estimates with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N14 · How far are the Wong report identity and results linked? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The preserved bibliography contains Wong 2013, PMID 24111816, its DOI and a summary of an Asian trial with concurrent care. There is no separate evidence row for this report. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong. - Required materials and conditions: Design, denominators and results of the citation-only report - Materials to obtain first: The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong. - Further research: Material needed: The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Design, denominators and results of the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Design, denominators and results of the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S02 ### N15 · Which report concerns the more favorable 8-week trial? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The existing Korean and English narratives mention a more favorable 8-week trial. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail. - Required materials and conditions: Links between the parent trial narrative and its report, denominators and outcomes - Materials to obtain first: Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail. - Further research: Material needed: Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Links between the parent trial narrative and its report, denominators and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Links between the parent trial narrative and its report, denominators and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S02 ### N16 · How are review size and individual trials distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Bakaa is preserved as a systematic review and Bayesian meta-analysis of 10 randomized trials and 307 participants. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total. - Required materials and conditions: Included trials, outcome-specific denominators, overlap and unpublished data - Materials to obtain first: Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total. - Further research: Material needed: Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Included trials, outcome-specific denominators, overlap and unpublished data must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Included trials, outcome-specific denominators, overlap and unpublished data with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N17 · What is known about the EASI-50 response figures? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The meta-analysis summary retains EASI-50 22% versus 32%. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated. - Required materials and conditions: Response definitions, arm mapping, denominators, timing and models - Materials to obtain first: Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated. - Further research: Material needed: Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Response definitions, arm mapping, denominators, timing and models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Response definitions, arm mapping, denominators, timing and models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S03 ### N18 · What statistics are the EASI ratio of means and interval? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The preserved ratio of means is 0.78 (95% CrI 0.59 to 0.99). The credible interval is not converted into a frequentist CI or risk ratio. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria. - Required materials and conditions: Ratio of means, arm direction, Bayesian interval and model - Materials to obtain first: Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria. - Further research: Material needed: Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Ratio of means, arm direction, Bayesian interval and model must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Ratio of means, arm direction, Bayesian interval and model with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S03 ### N19 · What does the historical moderate-certainty wording mean? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account preserves historical wording describing a small EASI signal with moderate certainty. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade. - Required materials and conditions: Outcome-specific review certainty and current content-review status - Materials to obtain first: Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade. - Further research: Material needed: Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Outcome-specific review certainty and current content-review status must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Outcome-specific review certainty and current content-review status with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S03 ### N20 · Are clinician-rated and patient-experienced outcomes distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The small clinician-rated signal and uncertainty in patient-reported outcomes are both retained. Patient reports form a separate existing question. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life. - Required materials and conditions: EASI and SCORAD versus itch, sleep and quality of life - Materials to obtain first: Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life. - Further research: Material needed: Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for EASI and SCORAD versus itch, sleep and quality of life must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links EASI and SCORAD versus itch, sleep and quality of life with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S03 ### N21 · Are colonization, clinical infection and severity distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Colonization RR 0.89 (0.73 to 1.09) and unestablished clinical infection benefit are retained. Colonization and infection form a different existing question. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication. - Required materials and conditions: Microbial colonization, infection events and severity outcomes - Materials to obtain first: Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication. - Further research: Material needed: Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Microbial colonization, infection events and severity outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Microbial colonization, infection events and severity outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S03 ### N22 · Were prespecified outcomes, registration and analysis plans verified? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account retains gaps in prespecified primary outcomes for favorable evidence. Original wording of unverified Hon registration and registration not applicable to the review is preserved. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work. - Required materials and conditions: Trial-specific primary outcomes, changes and analysis plans - Materials to obtain first: Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work. - Further research: Material needed: Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Trial-specific primary outcomes, changes and analysis plans must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Trial-specific primary outcomes, changes and analysis plans with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N23 · Are heterogeneity and replication across concentrations, concurrent care and controls known? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The stored account retains different concentrations, treatments, small samples and water-bath effects as limitations. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication. - Required materials and conditions: Study relationships under the same intervention, population, comparator and outcome - Materials to obtain first: Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication. - Further research: Material needed: Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Study relationships under the same intervention, population, comparator and outcome must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Study relationships under the same intervention, population, comparator and outcome with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N24 · Do short-term findings establish long-term effects or an optimal dose? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon periods of 4 weeks and the parent narrative of an 8-week trial are preserved separately. Findings from different durations or formulations are not combined as the same net effect. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created. - Required materials and conditions: Duration, products, exposure and persistence after treatment - Materials to obtain first: Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created. - Further research: Material needed: Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Duration, products, exposure and persistence after treatment must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Duration, products, exposure and persistence after treatment with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N25 · How do Hon funding details relate to the parent public-funding wording? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The Hon evidence leaves specific funding and COI unverified. The parent explanation describes a publicly funded water-controlled trial as a strength; both original statements are retained. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified. - Required materials and conditions: Report-specific funding, product support, employee authors and conflicts - Materials to obtain first: Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified. - Further research: Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Report-specific funding, product support, employee authors and conflicts must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Report-specific funding, product support, employee authors and conflicts with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01 ### N26 · Were Wong funding, support and conflicts verified? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The Wong bibliography and concurrent-treatment summary are preserved, but there is no individual funding field. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts. - Required materials and conditions: Support and roles in the citation-only report - Materials to obtain first: Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts. - Further research: Material needed: Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Support and roles in the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Support and roles in the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S02 ### N27 · Were review support and included-trial support distinguished? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The Bakaa evidence preserves wording of academic or public investigators and no specific manufacturer support reported. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial. - Required materials and conditions: Funding, support and roles for the review and each original trial - Materials to obtain first: Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial. - Further research: Material needed: Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Funding, support and roles for the review and each original trial must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Funding, support and roles for the review and each original trial with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S03 ### N28 · Were harm events and arm-specific denominators verified? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Review outcomes include adverse events. The parent caution label is retained. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification. - Required materials and conditions: Adverse-event definitions, collection, events, withdrawals and timing - Materials to obtain first: Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification. - Further research: Material needed: Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Adverse-event definitions, collection, events, withdrawals and timing must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Adverse-event definitions, collection, events, withdrawals and timing with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N29 · Are long-term and vulnerable-group safety and use boundaries known? Verification status: Unverified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The parent caution wording is preserved. This table creates no new dilution, treatment or procedural guidance. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use. - Required materials and conditions: Harms by product, population and repeated exposure - Materials to obtain first: Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use. - Further research: Material needed: Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Harms by product, population and repeated exposure must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Harms by product, population and repeated exposure with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N30 · Were shared reports and review populations kept from duplicate counting? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Hon, Wong and Bakaa are reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed are preserved separately without a new sum. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified. - Required materials and conditions: Relationships among reports, trial families, cohorts and outcomes - Materials to obtain first: Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified. - Further research: Material needed: Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Relationships among reports, trial families, cohorts and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Relationships among reports, trial families, cohorts and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N31 · How are the existing verdict and missing-field structure retained? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: Parent C50, the Korean and English narratives and assessment axes are preserved. Original subclaim C, its explanation, absent individual score, status and axes, and empty correction and deliberation records are retained. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification. - Required materials and conditions: Parent context, subclaim C, explanation and change history - Materials to obtain first: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification. - Further research: Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Parent context, subclaim C, explanation and change history must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Parent context, subclaim C, explanation and change history with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ### N32 · What are the evidence date and materials actually read in this work? Verification status: Partly verified Reading scope: Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread - Current findings: The original verdict evidence date is 2026-09-07. Stored JSON summaries were read; external papers, registrations, protocols and SAPs remain unread with access not attempted. - Why unverified: Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review. - Reason for missing information: If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review. - Required materials and conditions: Original evidence date, production date and material-specific access states - Materials to obtain first: If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review. - Further research: Material needed: If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review. This records needed materials; no new research was executed. - Conditions for verification: Original material and analysis scope for Original evidence date, production date and material-specific access states must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes. - Why this condition is needed: This condition links Original evidence date, production date and material-specific access states with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question. - Application exceptions: Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created. - Remaining uncertainty: External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety. - Referenced methods: Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced. - Related sources: S01, S02, S03 ## Evidence and sources ### S01 Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669. [PubMed](https://pubmed.ncbi.nlm.nih.gov/26270469/) Materials actually read: Stored summary read; external materials unread Findings recorded in the summary: No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03 Record level: Hon's 2016 double-blind crossover trial retains 40 completed, 14 nonadherent and no added benefit by ITT. Affected-area SCORAD change is water -5.7±15.4 versus bleach 0.6±12.4, P=.03. This is not converted into total SCORAD or EASI, and dispersion type, CIs and outcome-specific denominators are not established. Independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Funding, product support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | ### S02 Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265. [PubMed](https://pubmed.ncbi.nlm.nih.gov/24111816/) Materials actually read: Stored summary read; external materials unread Findings recorded in the summary: The stored citation summary separates an Asian trial with concurrent care. Record level: Wong 2013 is a citation-only report. The bibliography and summary of an Asian trial with concurrent care are preserved, but there is no separate evidence row. Design, denominators, severity findings, arm-specific effects, concentration and exact mapping to the parent 8-week trial remain unverified. Independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Funding, product support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | ### S03 Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024. [PubMed](https://pubmed.ncbi.nlm.nih.gov/35367346/) Materials actually read: Stored summary read; external materials unread Findings recorded in the summary: EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09) Record level: Bakaa 2022 synthesizes 10 trials and 307 participants, distinguishing EASI-50 22% versus 32%, ratio of means 0.78 (95% CrI 0.59 to 0.99) and colonization RR 0.89 (0.73 to 1.09). Arms, original denominators, timing, models, trial inclusion and unpublished materials are unverified. These findings are not transferred to patient reports or infection prevention, and no new total is created. Independent replication: Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | | Funding, product support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Partly verified: Partial information from the stored summary is linked; detailed originals and content review remain incomplete. - Unverified: Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety. - Review incomplete: Review of existing content remains incomplete. - Met: This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work. - Not reported: Unreported within material actually read. Unread external material is not relabeled as unreported. - Inaccessible: This means actual access failure. External access was not attempted in this work, so this state was not assigned. - Not applicable: Used only with an application exception and reason based on the question scope. - Conflicting data: This requires actual comparison of materials; no new conflict judgment was made in this work. - Insufficient evidence for the conditions: This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade. ## Change history 2026-10-19 · Public page/materials 1.0. Public-facing views and materials were prepared from the existing 32 items. No new clinical search, verification-status change or scoring was performed.