{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3008-s0", "verdict_number": "3008", "title": "Dilute sodium-hypochlorite baths added to standard care × Improved clinician-rated atopic-dermatitis severity", "view_version": "1.0", "view_created_date": "2026-10-19", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "The stored materials concern moderate-to-severe atopic dermatitis. Hon's 40 completed and 14 nonadherent and the review's 10 trials and 307 participants are kept in their respective contexts. Trial-specific age, diagnosis, severity, eligibility and outcome-specific denominators are unverified; no new participant total is created.", "intervention": "The intervention is dilute sodium-hypochlorite bathing added to standard care. Continued emollients and topical treatment are distinguished from simultaneous antibiotic changes in some trials. Trial-specific products, concentrations, ingredients, quality and actual exposure are unverified; no new dilution, treatment or procedural instructions are created.", "dose": "Hon's schedule of 2 times per week and 4 weeks per period is preserved as a study record. A formulation name is not a quantitative dose; final concentrations, products, actual exposure and adherence details are unverified. This schedule is not converted into personal-use instructions or an optimal dose.", "comparator": "Hon's same-water control is distinguished from usual-care comparisons in the stored narrative. Original materials are needed to map shared bathing, contact, emollients, topical treatment and antibiotic changes. Common improvement is not converted into an ingredient-specific added effect, and different controls are not combined as the same comparison.", "endpoint": "The selection is improved clinician-rated atopic-dermatitis severity, retaining original subclaim C and absent individual score, status and axes. Hon's SCORAD, affected area and topical medication outcomes are distinguished from the review's EASI and EASI-50. A small pooled signal and a null water-controlled trial are both preserved without transferring effects to patient reports, colonization or infection or issuing new efficacy or equivalence judgments.", "duration": "Hon's 4-week crossover periods are separated from the parent narrative of a more favorable 8-week trial. Exact links to the 8-week report, arms and outcomes and information on washout, carryover and long-term persistence are unverified. The Wong bibliography alone does not fill duration-specific findings, and short-term results are not extended into long-term efficacy or safety.", "excluded_extensions": [ "SCORAD, affected area, EASI, EASI-50, patient reports, colonization and clinical infection are not merged into one outcome.", "Original arm direction, denominators, timing and Bayesian credible intervals are retained; no new effects, differences or totals are calculated.", "Wong's citation-only summary and Bakaa's meta-analysis evidence are distinguished; original trials, reports and review populations are not double counted.", "Same-water controls and usual care are distinguished, and improvement under shared treatment is not converted into an effect of the bleach ingredient alone.", "Original subclaim C and parent C50 context are retained without creating new concentrations, dilution methods, procedural or treatment guidance, or safety certification." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What are the selected clinician-rated severity question and the parent verdict?", "needed": "Original subclaim C, explanation and parent-verdict context", "role": "Required", "role_reason": "This condition links Original subclaim C, explanation and parent-verdict context with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Original subclaim C, explanation and parent-verdict context must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The selection concerns improved clinician-rated atopic-dermatitis severity, with original subclaim C. Its explanation retains a small pooled EASI signal alongside a null water-controlled trial. Parent C50 is contextual.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Which atopic-dermatitis populations were studied?", "needed": "Trial-specific age, diagnosis, baseline severity and eligibility", "role": "Required", "role_reason": "This condition links Trial-specific age, diagnosis, baseline severity and eligibility with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Trial-specific age, diagnosis, baseline severity and eligibility must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The parent question concerns moderate-to-severe atopic dermatitis. The Hon bibliography describes childhood-onset moderate-to-severe eczema.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Were the products and formulations of the dilute baths specified?", "needed": "Products, ingredients, final concentrations and trial-specific formulations", "role": "Required", "role_reason": "This condition links Products, ingredients, final concentrations and trial-specific formulations with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Products, ingredients, final concentrations and trial-specific formulations must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The intervention is dilute sodium-hypochlorite bathing added to standard care. The stored account explains that concentrations and product formulations are not interchangeable.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Were same-water bathing and usual-care comparisons distinguished?", "needed": "Water controls, usual care and shared bathing conditions", "role": "Required", "role_reason": "This condition links Water controls, usual care and shared bathing conditions with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Water controls, usual care and shared bathing conditions must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon is a direct crossover comparison against water bathing. The stored account lists comparisons against water or usual care.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Were shared effects of emollients and topical care distinguished?", "needed": "Concurrent care, changes, medication use and adherence", "role": "Required", "role_reason": "This condition links Concurrent care, changes, medication use and adherence with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Concurrent care, changes, medication use and adherence must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account states that emollients and topical care continued and that standard treatment was not withdrawn.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Which reports link to simultaneous antibiotic changes?", "needed": "Antibiotic changes, arms, timing and effect attribution", "role": "Required", "role_reason": "This condition links Antibiotic changes, arms, timing and effect attribution with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Antibiotic changes, arms, timing and effect attribution must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong. This records needed materials; no new research was executed.", "current_reports": [ "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account separates simultaneous antibiotic changes in some trials from bleach-only effects. The Wong bibliography contains a summary of an Asian trial with concurrent treatment.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What is known about randomization and masking in Hon?", "needed": "Sequence allocation, concealment, masking and assessment roles", "role": "Required", "role_reason": "This condition links Sequence allocation, concealment, masking and assessment roles with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Sequence allocation, concealment, masking and assessment roles must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon is preserved as a double-blind randomized crossover trial of bleach versus water.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Were periods and carryover effects distinguished in Hon?", "needed": "Periods, washout, sequence effects and analysis models", "role": "Required", "role_reason": "This condition links Periods, washout, sequence effects and analysis models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Periods, washout, sequence effects and analysis models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account retains the study schedule of 2 times per week and 4 weeks per period. This is a study record rather than personal-use guidance.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "How were completers and nonadherent participants recorded?", "needed": "Recruitment, allocation, completion, adherence and analysis denominators", "role": "Required", "role_reason": "This condition links Recruitment, allocation, completion, adherence and analysis denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Recruitment, allocation, completion, adherence and analysis denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The preserved evidence states 40 completed and 14 nonadherent. The narrative describes a 40-person crossover trial.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Were the null ITT result and adherence analyses distinguished?", "needed": "Analysis populations, missing-data handling, ITT and PP", "role": "Required", "role_reason": "This condition links Analysis populations, missing-data handling, ITT and PP with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Analysis populations, missing-data handling, ITT and PP must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon is preserved as finding no added bleach benefit by ITT.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Were SCORAD, affected-area and topical-medication findings distinguished?", "needed": "Outcomes, measures, assessors, timing and hierarchy", "role": "Required", "role_reason": "This condition links Outcomes, measures, assessors, timing and hierarchy with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Outcomes, measures, assessors, timing and hierarchy must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon lists SCORAD, affected area and topical medication use as outcomes. These are not merged into one outcome or converted into EASI.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "What are the figures for the water-favoring affected-area result?", "needed": "Arm-specific changes, dispersion notation, P value and denominators", "role": "Required", "role_reason": "This condition links Arm-specific changes, dispersion notation, P value and denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Arm-specific changes, dispersion notation, P value and denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Affected-area SCORAD change is preserved as water -5.7±15.4 versus bleach 0.6±12.4, P=.03.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Were overall added benefit and individual findings distinguished in Hon?", "needed": "Overall findings, component findings, multiplicity and estimates", "role": "Required", "role_reason": "This condition links Overall findings, component findings, multiplicity and estimates with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Overall findings, component findings, multiplicity and estimates must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored summary retains both no added bleach benefit by ITT and a water-favoring affected-area result.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "How far are the Wong report identity and results linked?", "needed": "Design, denominators and results of the citation-only report", "role": "Required", "role_reason": "This condition links Design, denominators and results of the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Design, denominators and results of the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The preserved bibliography contains Wong 2013, PMID 24111816, its DOI and a summary of an Asian trial with concurrent care. There is no separate evidence row for this report.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Which report concerns the more favorable 8-week trial?", "needed": "Links between the parent trial narrative and its report, denominators and outcomes", "role": "Required", "role_reason": "This condition links Links between the parent trial narrative and its report, denominators and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Links between the parent trial narrative and its report, denominators and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The existing Korean and English narratives mention a more favorable 8-week trial.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "How are review size and individual trials distinguished?", "needed": "Included trials, outcome-specific denominators, overlap and unpublished data", "role": "Required", "role_reason": "This condition links Included trials, outcome-specific denominators, overlap and unpublished data with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Included trials, outcome-specific denominators, overlap and unpublished data must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Bakaa is preserved as a systematic review and Bayesian meta-analysis of 10 randomized trials and 307 participants.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "What is known about the EASI-50 response figures?", "needed": "Response definitions, arm mapping, denominators, timing and models", "role": "Required", "role_reason": "This condition links Response definitions, arm mapping, denominators, timing and models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Response definitions, arm mapping, denominators, timing and models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The meta-analysis summary retains EASI-50 22% versus 32%.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "What statistics are the EASI ratio of means and interval?", "needed": "Ratio of means, arm direction, Bayesian interval and model", "role": "Required", "role_reason": "This condition links Ratio of means, arm direction, Bayesian interval and model with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Ratio of means, arm direction, Bayesian interval and model must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The preserved ratio of means is 0.78 (95% CrI 0.59 to 0.99). The credible interval is not converted into a frequentist CI or risk ratio.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "What does the historical moderate-certainty wording mean?", "needed": "Outcome-specific review certainty and current content-review status", "role": "Required", "role_reason": "This condition links Outcome-specific review certainty and current content-review status with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Outcome-specific review certainty and current content-review status must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account preserves historical wording describing a small EASI signal with moderate certainty.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are clinician-rated and patient-experienced outcomes distinguished?", "needed": "EASI and SCORAD versus itch, sleep and quality of life", "role": "Required", "role_reason": "This condition links EASI and SCORAD versus itch, sleep and quality of life with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for EASI and SCORAD versus itch, sleep and quality of life must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The small clinician-rated signal and uncertainty in patient-reported outcomes are both retained. Patient reports form a separate existing question.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Are colonization, clinical infection and severity distinguished?", "needed": "Microbial colonization, infection events and severity outcomes", "role": "Required", "role_reason": "This condition links Microbial colonization, infection events and severity outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Microbial colonization, infection events and severity outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Colonization RR 0.89 (0.73 to 1.09) and unestablished clinical infection benefit are retained. Colonization and infection form a different existing question.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Were prespecified outcomes, registration and analysis plans verified?", "needed": "Trial-specific primary outcomes, changes and analysis plans", "role": "Required", "role_reason": "This condition links Trial-specific primary outcomes, changes and analysis plans with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Trial-specific primary outcomes, changes and analysis plans must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account retains gaps in prespecified primary outcomes for favorable evidence. Original wording of unverified Hon registration and registration not applicable to the review is preserved.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are heterogeneity and replication across concentrations, concurrent care and controls known?", "needed": "Study relationships under the same intervention, population, comparator and outcome", "role": "Required", "role_reason": "This condition links Study relationships under the same intervention, population, comparator and outcome with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Study relationships under the same intervention, population, comparator and outcome must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The stored account retains different concentrations, treatments, small samples and water-bath effects as limitations.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Do short-term findings establish long-term effects or an optimal dose?", "needed": "Duration, products, exposure and persistence after treatment", "role": "Required", "role_reason": "This condition links Duration, products, exposure and persistence after treatment with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Duration, products, exposure and persistence after treatment must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon periods of 4 weeks and the parent narrative of an 8-week trial are preserved separately. Findings from different durations or formulations are not combined as the same net effect.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "How do Hon funding details relate to the parent public-funding wording?", "needed": "Report-specific funding, product support, employee authors and conflicts", "role": "Required", "role_reason": "This condition links Report-specific funding, product support, employee authors and conflicts with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Report-specific funding, product support, employee authors and conflicts must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The Hon evidence leaves specific funding and COI unverified. The parent explanation describes a publicly funded water-controlled trial as a strength; both original statements are retained.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "Were Wong funding, support and conflicts verified?", "needed": "Support and roles in the citation-only report", "role": "Required", "role_reason": "This condition links Support and roles in the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Support and roles in the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The Wong bibliography and concurrent-treatment summary are preserved, but there is no individual funding field.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Were review support and included-trial support distinguished?", "needed": "Funding, support and roles for the review and each original trial", "role": "Required", "role_reason": "This condition links Funding, support and roles for the review and each original trial with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Funding, support and roles for the review and each original trial must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The Bakaa evidence preserves wording of academic or public investigators and no specific manufacturer support reported.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "Were harm events and arm-specific denominators verified?", "needed": "Adverse-event definitions, collection, events, withdrawals and timing", "role": "Supplementary", "role_reason": "This condition links Adverse-event definitions, collection, events, withdrawals and timing with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Adverse-event definitions, collection, events, withdrawals and timing must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Review outcomes include adverse events. The parent caution label is retained.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Are long-term and vulnerable-group safety and use boundaries known?", "needed": "Harms by product, population and repeated exposure", "role": "Supplementary", "role_reason": "This condition links Harms by product, population and repeated exposure with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Harms by product, population and repeated exposure must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The parent caution wording is preserved. This table creates no new dilution, treatment or procedural guidance.", "condition_status": "Unverified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "Were shared reports and review populations kept from duplicate counting?", "needed": "Relationships among reports, trial families, cohorts and outcomes", "role": "Required", "role_reason": "This condition links Relationships among reports, trial families, cohorts and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Relationships among reports, trial families, cohorts and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Hon, Wong and Bakaa are reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed are preserved separately without a new sum.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "How are the existing verdict and missing-field structure retained?", "needed": "Parent context, subclaim C, explanation and change history", "role": "Required", "role_reason": "This condition links Parent context, subclaim C, explanation and change history with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Parent context, subclaim C, explanation and change history must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "Parent C50, the Korean and English narratives and assessment axes are preserved. Original subclaim C, its explanation, absent individual score, status and axes, and empty correction and deliberation records are retained.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "What are the evidence date and materials actually read in this work?", "needed": "Original evidence date, production date and material-specific access states", "role": "Required", "role_reason": "This condition links Original evidence date, production date and material-specific access states with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.", "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.", "criterion": "Original material and analysis scope for Original evidence date, production date and material-specific access states must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.", "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03" ], "existence": "Stored-summary and bibliographic statements were used; identity, exact content, acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external papers, abstracts, full texts, registration, protocols, analysis plans and support materials unread", "observation": "The original verdict evidence date is 2026-09-07. Stored JSON summaries were read; external papers, registrations, protocols and SAPs remain unread with access not attempted.", "condition_status": "Partly verified", "status_reason": "Information was transferred from the stored summary while distinguishing the existing selected question from parent material. Detailed originals are unverified and review of existing content remains incomplete. This does not establish clinical certification or a passed content review.", "missingness": "If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review.", "uncertainty": "External originals are unread and review of existing content remains incomplete. The small EASI signal, null water-controlled trial and original subclaim C are retained alongside gaps in direct net effects, prespecified plans, arm-specific denominators, crossover analyses, precision, concurrent care, support and harms. Bibliography, historical assessments and design labels do not establish current reading or certification of independence, efficacy or safety.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review." } ], "reports": [ { "report_id": "S01", "title": "Hon KL, Tsang YC, Lee VW, et al. Efficacy of sodium hypochlorite (bleach) baths to reduce Staphylococcus aureus colonization in childhood onset moderate-to-severe eczema: a randomized, placebo-controlled cross-over trial. J Dermatolog Treat. 2016;27:156-162. PMID: 26270469. DOI: 10.3109/09546634.2015.1067669.", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/", "report_type": "Stored water-controlled trial directly related to clinician-rated severity", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; review inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total.", "observed_result": "No added bleach benefit by ITT; affected-area SCORAD change favored water, -5.7±15.4 versus 0.6±12.4, P=.03", "result_level": "Hon's 2016 double-blind crossover trial retains 40 completed, 14 nonadherent and no added benefit by ITT. Affected-area SCORAD change is water -5.7±15.4 versus bleach 0.6±12.4, P=.03. This is not converted into total SCORAD or EASI, and dispersion type, CIs and outcome-specific denominators are not established.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID26270469, DOI10.3109/09546634.2015.1067669 and unverified registration. Hon's unverified specific funding and COI and the parent public-funding wording are both retained; neither fills missing support fields. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26270469/" } ] }, { "report_id": "S02", "title": "Wong SM, Ng TG, Baba R. Efficacy and safety of sodium hypochlorite (bleach) baths in patients with moderate to severe atopic dermatitis in Malaysia. J Dermatol. 2013. PMID: 24111816. DOI: 10.1111/1346-8138.12265.", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/", "report_type": "Preserved bibliography and summary of a citation-only concurrent-care trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; review inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total.", "observed_result": "The stored citation summary separates an Asian trial with concurrent care.", "result_level": "Wong 2013 is a citation-only report. The bibliography and summary of an Asian trial with concurrent care are preserved, but there is no separate evidence row. Design, denominators, severity findings, arm-specific effects, concentration and exact mapping to the parent 8-week trial remain unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve the citation-only bibliography with original PMID24111816 and DOI10.1111/1346-8138.12265. Registration, funding, product support, author roles, COI and exact findings are unverified. Bakaa materials or the parent 8-week narrative do not fill these details. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/24111816/" } ] }, { "report_id": "S03", "title": "Bakaa L, Pernica JM, Couban RJ, et al. Bleach baths for atopic dermatitis: a systematic review and meta-analysis including unpublished data, Bayesian interpretation, and GRADE. Ann Allergy Asthma Immunol. 2022;128:660-668.e9. PMID: 35367346. DOI: 10.1016/j.anai.2022.03.024.", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/", "report_type": "Stored evidence synthesis distinguishing clinician-rated severity from other outcomes", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Report links shared by existing questions; review inclusion, unique counts and independence unverified", "independent_replication": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total.", "observed_result": "EASI-50 22% versus 32%; ratio of means 0.78 (95% CrI 0.59 to 0.99); colonization RR 0.89 (0.73 to 1.09)", "result_level": "Bakaa 2022 synthesizes 10 trials and 307 participants, distinguishing EASI-50 22% versus 32%, ratio of means 0.78 (95% CrI 0.59 to 0.99) and colonization RR 0.89 (0.73 to 1.09). Arms, original denominators, timing, models, trial inclusion and unpublished materials are unverified. These findings are not transferred to patient reports or infection prevention, and no new total is created.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." }, { "material_type": "Funding, product support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID35367346, DOI10.1016/j.anai.2022.03.024 and wording that registration is not applicable to the review. Academic or public investigators and no specific manufacturer support reported do not establish support or independence for each original trial. The material date belongs to the original evidence and is not a new external-reading or completed-content-review date." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35367346/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.", "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.", "Review incomplete": "Review of existing content remains incomplete.", "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.", "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.", "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.", "Not applicable": "Used only with an application exception and reason based on the question scope.", "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.", "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Hon, Wong and Bakaa are preserved reports shared across existing questions. The review of 10 trials and 307 participants and Hon 40 completed remain separate contexts. Review inclusion, overlap and unique trial, participant and independent-replication totals are unverified. Shared summaries are not counted as new independent replications or added to a total." }, "history": [ { "date": "2026-10-19", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public-facing views and materials were prepared from the existing 32 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-19" }