{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Dilute sodium-hypochlorite baths added to standard care × Improved clinician-rated atopic-dermatitis severity",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What are the selected clinician-rated severity question and the parent verdict?",
      "needed": "Original subclaim C, explanation and parent-verdict context",
      "role": "Required",
      "role_reason": "This condition links Original subclaim C, explanation and parent-verdict context with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original subclaim C, explanation and parent-verdict context must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The selection has no separate score, status or axes. Original structure and change records are needed; missing fields are not filled with parent values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Which atopic-dermatitis populations were studied?",
      "needed": "Trial-specific age, diagnosis, baseline severity and eligibility",
      "role": "Required",
      "role_reason": "This condition links Trial-specific age, diagnosis, baseline severity and eligibility with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Trial-specific age, diagnosis, baseline severity and eligibility must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Eligibility and baseline tables are needed to establish exact age, diagnostic and severity criteria for Wong and the trials included in the review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Were the products and formulations of the dilute baths specified?",
      "needed": "Products, ingredients, final concentrations and trial-specific formulations",
      "role": "Required",
      "role_reason": "This condition links Products, ingredients, final concentrations and trial-specific formulations with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Products, ingredients, final concentrations and trial-specific formulations must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original trial-specific product, concentration, quality and intervention specifications are needed. This material creates no new dilution or treatment instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Were same-water bathing and usual-care comparisons distinguished?",
      "needed": "Water controls, usual care and shared bathing conditions",
      "role": "Required",
      "role_reason": "This condition links Water controls, usual care and shared bathing conditions with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Water controls, usual care and shared bathing conditions must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original comparator, contact and bathing conditions are needed for each included trial. Differences versus usual care are not converted into ingredient-specific added effects versus the same water bath. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Were shared effects of emollients and topical care distinguished?",
      "needed": "Concurrent care, changes, medication use and adherence",
      "role": "Required",
      "role_reason": "This condition links Concurrent care, changes, medication use and adherence with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Concurrent care, changes, medication use and adherence must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm-specific concurrent care, changes, medication-use and adherence records are needed. Shared improvement is not attributed to the bath ingredient alone. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Which reports link to simultaneous antibiotic changes?",
      "needed": "Antibiotic changes, arms, timing and effect attribution",
      "role": "Required",
      "role_reason": "This condition links Antibiotic changes, arms, timing and effect attribution with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Antibiotic changes, arms, timing and effect attribution must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials are needed to establish which antibiotics, arms and time points changed in which trials and how these changes map specifically to Wong. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What is known about randomization and masking in Hon?",
      "needed": "Sequence allocation, concealment, masking and assessment roles",
      "role": "Required",
      "role_reason": "This condition links Sequence allocation, concealment, masking and assessment roles with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Sequence allocation, concealment, masking and assessment roles must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Protocols and procedural records are needed to verify sequence allocation, concealment, masking success and assessor and analyst roles. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Were periods and carryover effects distinguished in Hon?",
      "needed": "Periods, washout, sequence effects and analysis models",
      "role": "Required",
      "role_reason": "This condition links Periods, washout, sequence effects and analysis models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Periods, washout, sequence effects and analysis models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Crossover analysis plans and period-specific results are needed to verify washout, sequence and period effects, carryover assessment and repeated-data models. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "How were completers and nonadherent participants recorded?",
      "needed": "Recruitment, allocation, completion, adherence and analysis denominators",
      "role": "Required",
      "role_reason": "This condition links Recruitment, allocation, completion, adherence and analysis denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Recruitment, allocation, completion, adherence and analysis denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Flow diagrams and original tables are needed for total allocation, period- and sequence-specific denominators and the definition of nonadherence. No new population difference, attrition count or rate is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were the null ITT result and adherence analyses distinguished?",
      "needed": "Analysis populations, missing-data handling, ITT and PP",
      "role": "Required",
      "role_reason": "This condition links Analysis populations, missing-data handling, ITT and PP with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Analysis populations, missing-data handling, ITT and PP must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Analysis plans and original tables are needed for the ITT definition, missing-data handling, PP findings and adherence effects. Universal adherence or complete data for every outcome is not assumed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Were SCORAD, affected-area and topical-medication findings distinguished?",
      "needed": "Outcomes, measures, assessors, timing and hierarchy",
      "role": "Required",
      "role_reason": "This condition links Outcomes, measures, assessors, timing and hierarchy with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Outcomes, measures, assessors, timing and hierarchy must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Assessment manuals and plans are needed for measure definitions, assessors, relationships between total scores and components, and prespecified hierarchy. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What are the figures for the water-favoring affected-area result?",
      "needed": "Arm-specific changes, dispersion notation, P value and denominators",
      "role": "Required",
      "role_reason": "This condition links Arm-specific changes, dispersion notation, P value and denominators with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Arm-specific changes, dispersion notation, P value and denominators must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables are needed to establish the dispersion represented by ±, original analyses, CIs and outcome-specific denominators. This is not converted into total SCORAD or EASI effects, and no new difference is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Were overall added benefit and individual findings distinguished in Hon?",
      "needed": "Overall findings, component findings, multiplicity and estimates",
      "role": "Required",
      "role_reason": "This condition links Overall findings, component findings, multiplicity and estimates with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Overall findings, component findings, multiplicity and estimates must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials are needed for complete outcome tables, multiplicity and exact estimates. No new judgment about all severity effects is made from one finding. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "How far are the Wong report identity and results linked?",
      "needed": "Design, denominators and results of the citation-only report",
      "role": "Required",
      "role_reason": "This condition links Design, denominators and results of the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Design, denominators and results of the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The Wong original is needed for its exact design, denominators, severity outcomes, arm-specific effects and concentration. Adjacent Bakaa evidence is not transferred to Wong. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Which report concerns the more favorable 8-week trial?",
      "needed": "Links between the parent trial narrative and its report, denominators and outcomes",
      "role": "Required",
      "role_reason": "This condition links Links between the parent trial narrative and its report, denominators and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Links between the parent trial narrative and its report, denominators and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Bibliography and original tables are needed to identify the exact report, severity findings, prespecified primary outcome and net effect. The Wong bibliography alone does not fill every detail. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "How are review size and individual trials distinguished?",
      "needed": "Included trials, outcome-specific denominators, overlap and unpublished data",
      "role": "Required",
      "role_reason": "This condition links Included trials, outcome-specific denominators, overlap and unpublished data with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Included trials, outcome-specific denominators, overlap and unpublished data must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Included-trial lists, overlapping cohorts, outcome-specific analysis counts and unpublished originals are needed. Hon 40 or Wong is not added separately to create a new total. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is known about the EASI-50 response figures?",
      "needed": "Response definitions, arm mapping, denominators, timing and models",
      "role": "Required",
      "role_reason": "This condition links Response definitions, arm mapping, denominators, timing and models with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Response definitions, arm mapping, denominators, timing and models must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables are needed for arm mapping, original denominators, timing and analysis models. No new responder counts, effect rates or differences are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What statistics are the EASI ratio of means and interval?",
      "needed": "Ratio of means, arm direction, Bayesian interval and model",
      "role": "Required",
      "role_reason": "This condition links Ratio of means, arm direction, Bayesian interval and model with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Ratio of means, arm direction, Bayesian interval and model must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Analysis methods and original tables are needed for the measure, timing, ratio-of-means definition, priors, model, source data and clinical-importance criteria. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What does the historical moderate-certainty wording mean?",
      "needed": "Outcome-specific review certainty and current content-review status",
      "role": "Required",
      "role_reason": "This condition links Outcome-specific review certainty and current content-review status with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Outcome-specific review certainty and current content-review status must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review assessment rationales and bias tables are needed. Historical certainty is not declared to be current content review, methodology certification or a new efficacy grade. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are clinician-rated and patient-experienced outcomes distinguished?",
      "needed": "EASI and SCORAD versus itch, sleep and quality of life",
      "role": "Required",
      "role_reason": "This condition links EASI and SCORAD versus itch, sleep and quality of life with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for EASI and SCORAD versus itch, sleep and quality of life must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original trial reports and review tables are needed for each outcome. A clinician-rated score signal does not substitute for evidence of improved patient experience, sleep or quality of life. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are colonization, clinical infection and severity distinguished?",
      "needed": "Microbial colonization, infection events and severity outcomes",
      "role": "Required",
      "role_reason": "This condition links Microbial colonization, infection events and severity outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Microbial colonization, infection events and severity outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original results are needed separately for colonization, infection and severity. Colonization findings are not transferred into evidence of EASI effects, infection prevention or bacterial eradication. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Were prespecified outcomes, registration and analysis plans verified?",
      "needed": "Trial-specific primary outcomes, changes and analysis plans",
      "role": "Required",
      "role_reason": "This condition links Trial-specific primary outcomes, changes and analysis plans with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Trial-specific primary outcomes, changes and analysis plans must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original trial registrations, change histories, protocols, SAPs and severity-outcome hierarchy are needed. External materials were not read in this work. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are heterogeneity and replication across concentrations, concurrent care and controls known?",
      "needed": "Study relationships under the same intervention, population, comparator and outcome",
      "role": "Required",
      "role_reason": "This condition links Study relationships under the same intervention, population, comparator and outcome with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Study relationships under the same intervention, population, comparator and outcome must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Included-trial materials by formulation, concurrent care, control and duration are needed. The review is not counted as a new direct trial or used to establish independent replication. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "Do short-term findings establish long-term effects or an optimal dose?",
      "needed": "Duration, products, exposure and persistence after treatment",
      "role": "Required",
      "role_reason": "This condition links Duration, products, exposure and persistence after treatment with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Duration, products, exposure and persistence after treatment must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Duration-specific, product-specific, long-term and post-treatment materials are needed. No optimal dose or product interchangeability is established, and no new concentration or treatment method is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How do Hon funding details relate to the parent public-funding wording?",
      "needed": "Report-specific funding, product support, employee authors and conflicts",
      "role": "Required",
      "role_reason": "This condition links Report-specific funding, product support, employee authors and conflicts with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Report-specific funding, product support, employee authors and conflicts must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original Hon support, author-affiliation and COI materials and source mapping for the parent statement are needed. Public-funding wording does not fill individual support fields as verified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Were Wong funding, support and conflicts verified?",
      "needed": "Support and roles in the citation-only report",
      "role": "Required",
      "role_reason": "This condition links Support and roles in the citation-only report with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Support and roles in the citation-only report must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding, product-support, employee-author and COI materials are needed. Missing information is not converted into no support, independence or no conflicts. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Were review support and included-trial support distinguished?",
      "needed": "Funding, support and roles for the review and each original trial",
      "role": "Required",
      "role_reason": "This condition links Funding, support and roles for the review and each original trial with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Funding, support and roles for the review and each original trial must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Support, COI and role documents are needed for the review and each original trial. Review wording is not transferred into verified funding, supplies, employee authors or COI for every included trial. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Were harm events and arm-specific denominators verified?",
      "needed": "Adverse-event definitions, collection, events, withdrawals and timing",
      "role": "Supplementary",
      "role_reason": "This condition links Adverse-event definitions, collection, events, withdrawals and timing with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Adverse-event definitions, collection, events, withdrawals and timing must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Safety tables, exposure, timing, arm-specific events and denominators, and missing-data details are needed. Completion or severity findings are not converted into safety certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "Are long-term and vulnerable-group safety and use boundaries known?",
      "needed": "Harms by product, population and repeated exposure",
      "role": "Supplementary",
      "role_reason": "This condition links Harms by product, population and repeated exposure with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Harms by product, population and repeated exposure must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed on long-term use, vulnerable groups, concurrent exposures and respiratory, eye and skin harms. These gaps are not filled with assertions of safety or suitability for use. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "Were shared reports and review populations kept from duplicate counting?",
      "needed": "Relationships among reports, trial families, cohorts and outcomes",
      "role": "Required",
      "role_reason": "This condition links Relationships among reports, trial families, cohorts and outcomes with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Relationships among reports, trial families, cohorts and outcomes must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Review inclusion tables and trial and cohort links are needed. Overlap and unique trial, participant and independent-replication totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "How are the existing verdict and missing-field structure retained?",
      "needed": "Parent context, subclaim C, explanation and change history",
      "role": "Required",
      "role_reason": "This condition links Parent context, subclaim C, explanation and change history with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Parent context, subclaim C, explanation and change history must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original text and a separate change event are needed for amendments. Historical cross-checking is not inherited as completed current content review or clinical certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "What are the evidence date and materials actually read in this work?",
      "needed": "Original evidence date, production date and material-specific access states",
      "role": "Required",
      "role_reason": "This condition links Original evidence date, production date and material-specific access states with populations, formulations, water controls, concurrent care, outcomes, denominators, timing, analyses, precision, support and harms for the selected clinician-rated severity question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without filling a subclaim score with parent C50. Distinguish SCORAD, affected area, EASI, EASI-50, patient reports, colonization and infection. Do not fill Wong's citation-only context with Bakaa evidence or combine water, usual care, concurrent treatment, denominators, timing or Bayesian intervals. No new effects, independent totals, concentrations, dilution or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original evidence date, production date and material-specific access states must be linked to the report's severity outcomes, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details, original trials versus reviews and different outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: If new originals are supplied, the scope actually read and the update event must be recorded. Historical checking statements or URLs are not converted into current external reading or completed content review. This records needed materials; no new research was executed."
    }
  ]
}