{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Buteyko for Adult Asthma × Preventing Exacerbations or Replacing Inhaled Therapy — Unproven · Evidence and Gaps Sheet",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What are the selected exacerbation-prevention and inhaled-therapy-replacement question and the parent verdict?",
      "needed": "Selected claim, original grade and explanation versus the parent symptom and rescue-use context",
      "role": "Required",
      "role_reason": "This condition links Selected claim, original grade and explanation versus the parent symptom and rescue-use context with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Selected claim, original grade and explanation versus the parent symptom and rescue-use context must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The selection has no separate score, status or axes. Original structure and authorized change records are needed; missing fields are not filled with parent values. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are exacerbation prevention and inhaled-therapy replacement the same outcome?",
      "needed": "Separate definitions of exacerbation events, therapy replacement and medication reduction",
      "role": "Required",
      "role_reason": "This condition links Separate definitions of exacerbation events, therapy replacement and medication reduction with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Separate definitions of exacerbation events, therapy replacement and medication reduction must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original plans are needed for exacerbation definitions, the target replacement effect, whether complete withdrawal occurred and comparator conditions. No personal medication-withdrawal or tapering instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Which adults with asthma do the findings concern?",
      "needed": "Diagnosis, severity, baseline medication, recent exacerbations, age and eligibility",
      "role": "Required",
      "role_reason": "This condition links Diagnosis, severity, baseline medication, recent exacerbations, age and eligibility with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Diagnosis, severity, baseline medication, recent exacerbations, age and eligibility must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Trial-specific eligibility, baseline exacerbation risk, ICS doses and control levels are needed. The parent representative population is not used as the denominator for every trial or event, and no new total is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Which adjunctive Buteyko training was studied?",
      "needed": "Instructors, programs, contact, actual practice and existing care",
      "role": "Required",
      "role_reason": "This condition links Instructors, programs, contact, actual practice and existing care with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Instructors, programs, contact, actual practice and existing care must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Teaching, contact time, amounts of practice, adherence and trial-specific manuals are needed. Study descriptions are not converted into new breathing-practice instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are contact, expectations and background care the same across comparators?",
      "needed": "Mappings for education, sham devices, pranayama, active education and usual care",
      "role": "Required",
      "role_reason": "This condition links Mappings for education, sham devices, pranayama, active education and usual care with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Mappings for education, sham devices, pranayama, active education and usual care must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials are needed for teaching, contact, expectations and existing care for each comparator. Different comparisons are not pooled as one exacerbation-prevention or therapy-replacement effect. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Have allocation, masking and exacerbation assessment been verified?",
      "needed": "Allocation, concealment and masking of participants, assessors and analysts",
      "role": "Required",
      "role_reason": "This condition links Allocation, concealment and masking of participants, assessors and analysts with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Allocation, concealment and masking of participants, assessors and analysts must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Trial-specific allocation concealment, masking roles and independent exacerbation-assessment procedures are needed. Design labels are not treated as completed review of every bias domain. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What is established by Cooper's null exacerbation finding?",
      "needed": "Exacerbation definitions, event counts, arm-specific denominators, observation time, effects and CIs",
      "role": "Required",
      "role_reason": "This condition links Exacerbation definitions, event counts, arm-specific denominators, observation time, effects and CIs with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Exacerbation definitions, event counts, arm-specific denominators, observation time, effects and CIs must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables are needed for exacerbation event counts, arm-specific denominators, definitions, follow-up, estimates and CIs. A null finding does not establish an effect of 0 or equivalence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What is the hierarchy of symptom co-primary outcomes and exacerbations?",
      "needed": "The prespecified relationship of symptom and PD20 co-primary outcomes to exacerbations",
      "role": "Required",
      "role_reason": "This condition links The prespecified relationship of symptom and PD20 co-primary outcomes to exacerbations with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for The prespecified relationship of symptom and PD20 co-primary outcomes to exacerbations must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original plans, endpoint lists, analysis plans and records of exacerbation hierarchy, multiplicity and changes are needed. Symptom signals are not reassigned as successful exacerbation prevention. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What do Cooper's 90 participants, 69 completers and missingness mean?",
      "needed": "Assignment, completion, arm-specific analysis, missing exacerbations and analysis populations",
      "role": "Required",
      "role_reason": "This condition links Assignment, completion, arm-specific analysis, missing exacerbations and analysis populations with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Assignment, completion, arm-specific analysis, missing exacerbations and analysis populations must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original records are needed for completion by arm, exacerbation-analysis denominators, missingness, withdrawal reasons and assignment-based versus completer analyses. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are Bowler's rescue-use and ICS findings the same?",
      "needed": "Original beta2-agonist and ICS findings and tapering policies",
      "role": "Required",
      "role_reason": "This condition links Original beta2-agonist and ICS findings and tapering policies with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original beta2-agonist and ICS findings and tapering policies must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed for arm mappings, units, analysis rules, ICS effects and CIs, complete replacement, exacerbations and tapering policies. Median differences are not newly calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "How are Cooper's symptoms and rescue use distinguished from ICS and exacerbations?",
      "needed": "Values, denominators and prespecified hierarchy for each arm and outcome",
      "role": "Required",
      "role_reason": "This condition links Values, denominators and prespecified hierarchy for each arm and outcome with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Values, denominators and prespecified hierarchy for each arm and outcome must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct CIs, arm mappings, denominators and original plans are needed for each outcome. Symptom and rescue-use figures are not used as exacerbation event counts, ICS-replacement effects or cure. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "What are Cowie's primary asthma-control and secondary ICS findings?",
      "needed": "Primary findings, missing-data sensitivity and secondary ICS against active education",
      "role": "Required",
      "role_reason": "This condition links Primary findings, missing-data sensitivity and secondary ICS against active education with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Primary findings, missing-data sensitivity and secondary ICS against active education must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed for exacerbations, the extent of tapering, direct CIs and prespecified rules. Secondary ICS signals are not promoted into success on primary control or complete replacement of inhaled therapy. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "What do Cowie's 129 participants, 119 assessed and arm-specific withdrawals mean?",
      "needed": "Denominators for assignment, assessment and secondary outcomes, and missingness by arm",
      "role": "Required",
      "role_reason": "This condition links Denominators for assignment, assessment and secondary outcomes, and missingness by arm with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Denominators for assignment, assessment and secondary outcomes, and missingness by arm must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Materials are needed for arm-specific allocation, missingness, outcome-denominator relationships and missing taper-safety information. The original missing-as-failure sensitivity is not reproduced as a new analysis, and population differences are not calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What are Vagedes's primary and secondary findings and objective measures?",
      "needed": "Distinguishing voluntary control pause, ACQ and medication from FEV1 and FeNO",
      "role": "Required",
      "role_reason": "This condition links Distinguishing voluntary control pause, ACQ and medication from FEV1 and FeNO with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing voluntary control pause, ACQ and medication from FEV1 and FeNO must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct events and designs for exacerbation prevention and inhaled-therapy replacement, original plans and medication policies are needed. Control pause, ACQ and medication findings are not converted into confirmation of the selected question. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What do NCT03098849 and post-recruitment registration mean?",
      "needed": "Registration identifiers, timing, original plans and change history",
      "role": "Required",
      "role_reason": "This condition links Registration identifiers, timing, original plans and change history with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Registration identifiers, timing, original plans and change history must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original registration, recruitment and registration dates, changes and analysis plans are unread. Preserving an identifier is not labeled as verification of prespecification or new external reading. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "What does registration wording for the other trials mean?",
      "needed": "Distinguishing historical registration fields from current content verification",
      "role": "Required",
      "role_reason": "This condition links Distinguishing historical registration fields from current content verification with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing historical registration fields from current content verification must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original plans, registration or historical documents are needed. Historical statements of absence or uncertainty are not converted into completed new registry searches or content verification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the context of standard inhaled care and clinically supervised reduction?",
      "needed": "Existing care, clinical review and the extent of reduction within studies",
      "role": "Supplementary",
      "role_reason": "This condition links Existing care, clinical review and the extent of reduction within studies with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Existing care, clinical review and the extent of reduction within studies must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials are needed for medications, doses, reduction criteria, monitoring, complete withdrawal and replacement comparisons. The study context is not converted into personal medication-replacement or tapering instructions. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Have precision and clinical meaning for exacerbation prevention been established?",
      "needed": "Between-arm exacerbation effects, CIs, event denominators, severity and sample planning",
      "role": "Required",
      "role_reason": "This condition links Between-arm exacerbation effects, CIs, event denominators, severity and sample planning with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Between-arm exacerbation effects, CIs, event denominators, severity and sample planning must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct exacerbation effects, CIs, event denominators, sample plans and original severity-specific results are needed. No new relative risk, incidence or CI is calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "How are airway function, symptoms and exacerbations distinguished?",
      "needed": "Separate FEV1, PEF, PD20, FeNO, symptom and exacerbation findings",
      "role": "Required",
      "role_reason": "This condition links Separate FEV1, PEF, PD20, FeNO, symptom and exacerbation findings with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Separate FEV1, PEF, PD20, FeNO, symptom and exacerbation findings must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original materials, exact values, clinical events and analysis tables are needed for each outcome. Symptom signals are not reassigned as evidence of improved airway function, exacerbation prevention or inhaled-therapy replacement. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Do several weeks to 6 months answer long-term prevention or replacement questions?",
      "needed": "Trial-specific periods, persistence, long-term exacerbations and therapy outcomes",
      "role": "Supplementary",
      "role_reason": "This condition links Trial-specific periods, persistence, long-term exacerbations and therapy outcomes with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Trial-specific periods, persistence, long-term exacerbations and therapy outcomes must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct materials are needed for long-term exacerbations, hospitalization, emergency care, and safety and persistence of therapy replacement. The same observation period is not copied to every outcome or harm. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Have independent replication, heterogeneity and shared reports been established?",
      "needed": "Matching comparisons, exacerbation and replacement outcomes, support and population relationships",
      "role": "Required",
      "role_reason": "This condition links Matching comparisons, exacerbation and replacement outcomes, support and population relationships with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Matching comparisons, exacerbation and replacement outcomes, support and population relationships must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent materials under matching questions and analysis conditions, cohorts, plans, support and full results are needed. Unique trial, participant and independent-replication totals are not established or summed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Are Bowler and Cooper's funding, support and interests known?",
      "needed": "Funding, product and teaching support, employee authors, interests and roles",
      "role": "Required",
      "role_reason": "This condition links Funding, product and teaching support, employee authors, interests and roles with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Funding, product and teaching support, employee authors, interests and roles must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original funding, support, affiliations, interests and analysis-role materials are needed for each report. Uncertainty is not filled in as independent funding, absent support or absent interests. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Does Cowie's anonymous donation verify independence?",
      "needed": "Donors, teaching support, authorship, analysis roles and control",
      "role": "Required",
      "role_reason": "This condition links Donors, teaching support, authorship, analysis roles and control with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Donors, teaching support, authorship, analysis roles and control must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original documents are needed for donor identity, support, affiliations, COI and control over the study. Anonymous donations are not established as independent funding. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "What do Vagedes's public or institutional support and historical checks mean?",
      "needed": "Original support and COI wording versus materials actually read in this work",
      "role": "Required",
      "role_reason": "This condition links Original support and COI wording versus materials actually read in this work with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original support and COI wording versus materials actually read in this work must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External funding, affiliation, COI and role materials are unread in this work. Historical checks are not inherited as current reading, completed review or certification of independence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Have harms related to reduction or acute exacerbations been established?",
      "needed": "Harm definitions, events, denominators, timing, monitoring and discontinuation",
      "role": "Supplementary",
      "role_reason": "This condition links Harm definitions, events, denominators, timing, monitoring and discontinuation with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Harm definitions, events, denominators, timing, monitoring and discontinuation must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Trial-specific adverse events, denominators, observation times, discontinuation, safety monitoring and missingness are needed. General caution wording is not converted into absent events or harm incidence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "What is known about concurrent care, comparative harms and other populations?",
      "needed": "Existing medication, training exposure, comparator-specific harms and long-term risks",
      "role": "Supplementary",
      "role_reason": "This condition links Existing medication, training exposure, comparator-specific harms and long-term risks with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Existing medication, training exposure, comparator-specific harms and long-term risks must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Comparator-specific harms, concurrent exposures, alternative causes and direct acute, high-risk and long-term materials are needed. These are not converted into treatment-safety certification or new management guidance. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How are parent axes, bilingual wording, dates and corrections retained?",
      "needed": "Distinguishing parent grade and axes from selected D and absent fields",
      "role": "Required",
      "role_reason": "This condition links Distinguishing parent grade and axes from selected D and absent fields with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing parent grade and axes from selected D and absent fields must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original records and authorized correction events are needed. Parent values or historical checks are not inherited as subclaim scores, axes, new judgments or completed current content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Is reading the stored summary the same as reading external materials?",
      "needed": "Access status of originals, registration, protocols, analysis plans and support by report",
      "role": "Required",
      "role_reason": "This condition links Access status of originals, registration, protocols, analysis plans and support by report with populations, adjunctive training, comparators, medication policies, events, denominators, timing, analyses, precision, support and harms for the selected exacerbation-prevention or inhaled-therapy-replacement question.",
      "application_exception": "Retain original subclaim D and absent individual score, status and axes without inheriting parent C50 or positive-effect axes. Exacerbations, rescue use, maintenance ICS, asthma control, objective measures and complete therapy replacement are distinguished. Comparators, denominators, timing and prespecified hierarchy are not combined, and unread originals or registration and historical COI checks are not promoted into current verification. No new effects, CIs, independent totals, breathing, medication-change or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Access status of originals, registration, protocols, analysis plans and support by report must be linked to the report's exacerbation, medication and care-management findings, between-arm comparisons, denominators and timing, distinguishing stored summaries, unverified details and primary versus secondary outcomes.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual acquisition and reading of external papers, registration, plans and support materials are needed. Historical-check wording, URLs and original material dates alone do not raise verification status. This records needed materials; no new research was executed."
    }
  ]
}