{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Buteyko for Adult Asthma × Symptoms and Rescue Use — Signals Alongside Null Objective Findings · Evidence and Gaps Sheet",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Partial information from the stored summary is linked; detailed originals and content review remain incomplete.",
    "Unverified": "Required details cannot be established within the preserved scope. This does not establish absence of effects or studies, or safety.",
    "Review incomplete": "Review of existing content remains incomplete.",
    "Met": "This state is used only within the relevant conditions after material verification and content review. It was not automatically assigned in this work.",
    "Not reported": "Unreported within material actually read. Unread external material is not relabeled as unreported.",
    "Inaccessible": "This means actual access failure. External access was not attempted in this work, so this state was not assigned.",
    "Not applicable": "Used only with an application exception and reason based on the question scope.",
    "Conflicting data": "This requires actual comparison of materials; no new conflict judgment was made in this work.",
    "Insufficient evidence for the conditions": "This indicates gaps in additional material for the selected conditions. Unread material as a whole is not converted into an efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which symptom and rescue-use question and original verdict are being transferred?",
      "needed": "Original claim of reduced asthma symptoms and rescue bronchodilator use",
      "role": "Required",
      "role_reason": "This condition connects Original claim of reduced asthma symptoms and rescue bronchodilator use with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original claim of reduced asthma symptoms and rescue bronchodilator use must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original trials, measures, timing, denominators, between-group estimates and CIs for symptoms and rescue use separately are needed. No new claims or independence certification are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are symptoms, rescue bronchodilator use and inhaled-steroid use the same?",
      "needed": "Distinguishing symptoms, rescue use and maintenance-treatment reduction",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing symptoms, rescue use and maintenance-treatment reduction with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing symptoms, rescue use and maintenance-treatment reduction must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Medication types, symptom instruments, rescue decisions and records, maintenance-taper criteria, timing, denominators, effects and CIs are needed. No new medication-change or breathing instructions are provided. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "What were Bowler's rescue-use findings in 39 people at 3 months?",
      "needed": "Units and comparisons for beta2-agonist reduction in 1998",
      "role": "Required",
      "role_reason": "This condition connects Units and comparisons for beta2-agonist reduction in 1998 with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Units and comparisons for beta2-agonist reduction in 1998 must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original arm-specific medication, doses, baseline and follow-up values, estimands, direct CIs, denominators, collection and rescue or taper criteria are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are Bowler's lung-function, ICS and quality-of-life findings also retained?",
      "needed": "Distinguishing rescue use from FEV1, PEF, ICS and QOL",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing rescue use from FEV1, PEF, ICS and QOL with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing rescue use from FEV1, PEF, ICS and QOL must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Definitions, original values, CIs, denominators, timing, prespecified hierarchies, multiplicity and estimands for each outcome are needed. Nonsignificance does not certify a precise absence of effect or equivalence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What comparison underlies Cooper's 3-arm symptom changes?",
      "needed": "Symptom medians, 3-arm order, original contrasts and measures",
      "role": "Required",
      "role_reason": "This condition connects Symptom medians, 3-arm order, original contrasts and measures with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Symptom medians, 3-arm order, original contrasts and measures must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original arm tables, symptom instruments and direction, timing, denominators, prespecified contrasts, analyses and direct CIs are needed. The same P value or effect is not copied to every comparator. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What do Cooper's -2 puffs/day and P=.005 describe?",
      "needed": "Rescue-bronchodilator units, estimand and denominator",
      "role": "Required",
      "role_reason": "This condition connects Rescue-bronchodilator units, estimand and denominator with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Rescue-bronchodilator units, estimand and denominator must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Baseline and follow-up medications, devices, rescue conditions, records, direct between-group analyses, denominators and CIs are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Are the symptom and PD20 co-primary outcomes distinguished?",
      "needed": "Split co-primary outcomes, prespecified hierarchies and plans",
      "role": "Required",
      "role_reason": "This condition connects Split co-primary outcomes, prespecified hierarchies and plans with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Split co-primary outcomes, prespecified hierarchies and plans must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original prespecified plans, co-primary success rules, PD20 and symptom values, CIs, denominators and multiplicity hierarchies are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What analyses underlie 90 assigned, 69 completed and 23% attrition?",
      "needed": "Cooper completers, denominators and original attrition wording",
      "role": "Required",
      "role_reason": "This condition connects Cooper completers, denominators and original attrition wording with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Cooper completers, denominators and original attrition wording must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm-specific allocation, withdrawal reasons, completion, analysis populations, all-assigned and completer analyses, missingness, sensitivity and time-specific denominators are needed. No new attrition counts or proportions are calculated. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "What was Cowie's asthma-control primary versus active breathing education?",
      "needed": "Active comparison and asthma-control primary at 6 months",
      "role": "Required",
      "role_reason": "This condition connects Active comparison and asthma-control primary at 6 months with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Active comparison and asthma-control primary at 6 months must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Control definitions, arm denominators, active-education content, between-group effects, CIs, baseline adjustment, plans and missingness handling are needed. Original proportions are not subtracted into a new difference. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are Cowie's sensitivity analysis and secondary ICS findings primary success?",
      "needed": "Distinguishing missing-as-failure sensitivity, secondary ICS and primary control",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing missing-as-failure sensitivity, secondary ICS and primary control with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing missing-as-failure sensitivity, secondary ICS and primary control must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Analysis populations, missing-as-failure definitions, arm denominators, taper criteria, clinical review, direct effects, CIs, prespecified hierarchies and multiplicity are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Do Vagedes's primary and secondary symptom or medication outcomes in 60 people differ?",
      "needed": "Primary voluntary control pause and secondary ACQ or medication outcomes",
      "role": "Required",
      "role_reason": "This condition connects Primary voluntary control pause and secondary ACQ or medication outcomes with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Primary voluntary control pause and secondary ACQ or medication outcomes must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Individual outcomes, instruments, between-group values, CIs, denominators, timing, prespecified plans, changes and analyses are needed. No new breathing-practice or training instructions are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Are post-recruitment registration and historical COI checks treated as current verification?",
      "needed": "NCT03098849, later registration and historical full-text-check wording",
      "role": "Required",
      "role_reason": "This condition connects NCT03098849, later registration and historical full-text-check wording with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for NCT03098849, later registration and historical full-text-check wording must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original recruitment dates, registration and changes, protocols, analysis plans, outcome selection, support and COI disclosures are needed. An identifier does not certify prospective planning or independence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Are different breathing methods or education pooled as Buteyko effects?",
      "needed": "Asthma education, sham devices, pranayama, active breathing education and usual care",
      "role": "Required",
      "role_reason": "This condition connects Asthma education, sham devices, pranayama, active breathing education and usual care with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Asthma education, sham devices, pranayama, active breathing education and usual care must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Each intervention and comparator's content, intensity, instruction, contact, adherence, common inhaled care and original contrast are needed. No new breathing or education practice instructions are written. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Are adult-asthma eligibility, samples and outcome denominators distinguished?",
      "needed": "Diagnosis, severity, baseline medication, trial-specific recruitment and denominators",
      "role": "Required",
      "role_reason": "This condition connects Diagnosis, severity, baseline medication, trial-specific recruitment and denominators with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Diagnosis, severity, baseline medication, trial-specific recruitment and denominators must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Diagnosis, severity, baseline control, medications, age, comorbidity, exclusions and time- and arm-specific analyses and missingness are needed. Findings are not extended to other populations or acute attacks. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Are adjunctive training and clinician-reviewed tapering distinguished from isolated breathing effects?",
      "needed": "Standard inhaled care, medication adjustments, rescue criteria and adherence",
      "role": "Required",
      "role_reason": "This condition connects Standard inhaled care, medication adjustments, rescue criteria and adherence with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Standard inhaled care, medication adjustments, rescue criteria and adherence must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm-specific inhaled treatment, changes, rescue and taper criteria, concurrent education, actual adherence, medication types, original findings and denominators are needed. No new taper, withdrawal or breathing instructions are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are null FEV1, PEF, PD20 and FeNO obscured by symptom signals?",
      "needed": "Distinguishing objective physiology from perceived symptoms and medication use",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing objective physiology from perceived symptoms and medication use with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing objective physiology from perceived symptoms and medication use must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original values, units, between-group effects, CIs, timing, denominators, prespecified plans and links to symptoms for each measure are needed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Does reduced rescue use establish exacerbation prevention or inhaled-treatment replacement?",
      "needed": "Distinguishing rescue use, exacerbation events and maintenance inhaled care",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing rescue use, exacerbation events and maintenance inhaled care with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing rescue use, exacerbation events and maintenance inhaled care must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Exacerbation definitions, events, exposure, denominators, rescue, emergency care, admission, medication changes, safety, direct effects and CIs are needed. No new treatment or medication-adjustment guidance is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What are the limits of symptom measures, rescue records and lack of masking?",
      "needed": "Measurement, expectations, education, contact and selective reporting",
      "role": "Required",
      "role_reason": "This condition connects Measurement, expectations, education, contact and selective reporting with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Measurement, expectations, education, contact and selective reporting must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original assessor and participant masking, symptom tools, ACQ, medication diaries, record verification, contact time, withdrawals, missingness and outcome selection are needed. No new official risk-of-bias assessment was performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Are gaps in direct effects, CIs and clinical importance retained?",
      "needed": "Direct symptom and rescue-use effects and original precision",
      "role": "Required",
      "role_reason": "This condition connects Direct symptom and rescue-use effects and original precision with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Direct symptom and rescue-use effects and original precision must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Outcome-specific estimates, CIs, instruments, units, denominators, prespecified criteria, baseline adjustment and patient importance are needed. No new effects or CIs are calculated from medians, proportions or events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are consistent directions certified as new independent replications or participant totals?",
      "needed": "Linking institutions, funding, reports, recruitment and cohorts",
      "role": "Required",
      "role_reason": "This condition connects Linking institutions, funding, reports, recruitment and cohorts with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Linking institutions, funding, reports, recruitment and cohorts must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Links among reports, trials, registration, institutions, recruitment, participants, support, comparators and outcomes are needed. Unique trial and participant totals remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "Are company, donor and institutional support distinguished from design and analysis roles?",
      "needed": "Money, products, author affiliations, training provision, design and analysis",
      "role": "Required",
      "role_reason": "This condition connects Money, products, author affiliations, training provision, design and analysis with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Money, products, author affiliations, training provision, design and analysis must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Disclosures are needed separately for money and product support, author-company relationships, training provision, design, analysis, publication roles and supporter identities. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "How are harms, long-term effects and post-discontinuation persistence distinguished?",
      "needed": "Medication-taper and exacerbation harms, exposure, denominators and follow-up",
      "role": "Supplementary",
      "role_reason": "This condition connects Medication-taper and exacerbation harms, exposure, denominators and follow-up with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Medication-taper and exacerbation harms, exposure, denominators and follow-up must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm and exacerbation collection, events versus affected participants, severity, timing, exposure, denominators, clinical taper review, vulnerable populations and long follow-up are needed. No new breathing-training, medication-change or treatment guidance is created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "How do subclaim C and the parent's score and axes differ?",
      "needed": "Original subclaim grade and absent individual score, status and axes",
      "role": "Required",
      "role_reason": "This condition connects Original subclaim grade and absent individual score, status and axes with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original subclaim grade and absent individual score, status and axes must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: The parent-subclaim application boundary needs content review. No new grades, clinical statuses, scores or independence certification are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How does reading a stored summary differ from reading external materials?",
      "needed": "Distinguishing summaries, abstracts, full texts, registration, protocols and analysis plans",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing summaries, abstracts, full texts, registration, protocols and analysis plans with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing summaries, abstracts, full texts, registration, protocols and analysis plans must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External acquisition, actual reading and content review require separate records. URLs, PMCIDs or registration identifiers do not establish reading or completed review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "Are representative language or classification values copied to every report?",
      "needed": "Scope of parent Korean and English content, interventions, populations, comparisons and timing",
      "role": "Required",
      "role_reason": "This condition connects Scope of parent Korean and English content, interventions, populations, comparisons and timing with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Scope of parent Korean and English content, interventions, populations, comparisons and timing must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original populations, training, comparators, outcomes, timing and denominators for each report are needed for comparison. No new external English comparison or erratum-content review was performed. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are report or material-slot counts unique trials or quality scores?",
      "needed": "Distinguishing production structure, clinical units and actual reading",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing production structure, clinical units and actual reading with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing production structure, clinical units and actual reading must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Links among original trials, reports, recruitment and participants, and reading records for acquired materials, are needed. Unique trial and participant counts remain unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "Do original evidence dates, empty correction history and production dates differ?",
      "needed": "Original cut-off, correction and deliberation histories, and creation events",
      "role": "Required",
      "role_reason": "This condition connects Original cut-off, correction and deliberation histories, and creation events with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Original cut-off, correction and deliberation histories, and creation events must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Material additions, condition revisions, applied observations and verdict changes require separate events after preserving complete originals, followed by content review. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "Which items are updated when new materials or questions change?",
      "needed": "Distinguishing condition revisions, evidence updates and original-verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Distinguishing condition revisions, evidence updates and original-verdict changes with populations, interventions, comparators, medication types, measures, co-primary and secondary outcomes, timing, denominators, precision, support and harms for the selected symptom-and-rescue-use question.",
      "application_exception": "Retain original subclaim C and absent individual score, status and axes without inheriting parent C50 or axes. Symptoms, rescue use, ICS, objective lung function and exacerbations are distinguished without combining comparators, co-primary and secondary outcomes, denominators or times. Unread registration or originals and historical COI checks are not promoted into current verification; no new effects, CIs, independent totals, breathing practice, medication changes or treatment instructions are created.",
      "criterion": "Original material and analysis scope for Distinguishing condition revisions, evidence updates and original-verdict changes must be linked to the relevant trial's population, comparator, symptom and medication outcomes, timing and denominators, distinguishing stored summaries, unverified details, primary versus secondary outcomes and other clinical questions.",
      "basis": "Preserved application conditions concerning questions, comparisons, reports versus trials, outcomes, denominators, errata and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish clinical preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Complete originals, events, versions and change reasons must be retained. No new dilution, breathing, procedure, medication-change or treatment instructions are written. This records needed materials; no new research was executed."
    }
  ]
}