{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3005-s2", "verdict_number": "3005", "title": "Laughter Yoga × Treatment of Depressive or Anxiety Disorders · Evidence and Gaps Sheet", "view_version": "1.0", "view_created_date": "2026-10-19", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "The selection concerns treatment in patients with diagnosed depressive or anxiety disorders. The 4 currently preserved reports provide nonclinical context involving 120 healthy university students, nursing-student samples of 75 and 83, and 70 psychiatric nurses; they are not linked as direct treatment trials in patients with the selected diagnoses. Psychiatric nurses are an occupational sample. Diagnoses, eligibility, severity and patient denominators are unverified.", "intervention": "The parent program combines laughter, clapping, breathing, movement and group participation. Corresponding treatment aims, existing and concurrent treatments, instructors, actual exposure and adherence in diagnosed patients are unlinked in current material. Nonclinical programs are not reassigned as diagnosed-disorder treatment, and no new yoga, mental-health treatment or existing-treatment-change methods are provided.", "dose": "Single-exposure, 5-week or 8-session programs and the parent program of 8 sessions of 30 minutes are nonclinical research observation conditions. They are not converted into psychiatric-treatment doses or individual practice methods. Actual intervention exposure, concurrent treatment, participation and adherence for the selected diagnoses are unverified.", "comparator": "Parent no-intervention controls and insufficient active social controls, and Fujisawa's humorous video and reading, provide nonclinical context. Treatment comparators, active comparisons, concurrent treatment, contact and expectations in diagnosed patients are unverified. Video, breathing and social-participation findings are not converted into direct comparisons of diagnosed-disorder treatment.", "endpoint": "The selection is treatment of depressive or anxiety disorders, preserving the original English \"or\" wording. Original subclaim verdict '?' and absent separate score, status and assessment axes are retained. PSS, GHQ, burnout, well-being, self-efficacy, mental symptoms, cortisol and DHEA are not reassigned as direct diagnosed-treatment, remission, response, function or relapse outcomes. Corresponding direct outcomes are unlinked in current stored material.", "duration": "Treatment duration, persistence, function, relapse and post-discontinuation follow-up for the selected diagnoses are unlinked in current material. Parent-program observation periods are distinguished from diagnosed-treatment follow-up. Short-term nonclinical symptom and biomarker results are not extended to long-term treatment or remission.", "excluded_extensions": [ "Healthy student/nurse samples and psychiatric-workplace samples are not converted into patients diagnosed with depressive or anxiety disorders.", "Self-reported stress, mental-symptom and well-being findings are not reassigned as diagnosed-treatment, remission, function or relapse outcomes.", "Mixed cortisol/DHEA findings are not promoted to disorder treatment or confirmation of mechanism.", "Parent-program exposure periods, frequencies and components are not converted into individual psychiatric-treatment doses.", "Original '?' and absent separate score, status and axes are not filled with other grades, parent values or numbers from another subclaim explanation.", "Sharing the same reports/cohorts across sheets does not create new independent trial, patient or event totals.", "Nonclinical completion, measures and biomarkers are not converted into diagnosed-treatment safety or absence of long-term harms.", "No new yoga, mental-health treatment or methods to replace or discontinue existing treatment are provided." ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What are the selected treatment question and original verdict?", "needed": "The existing subclaim, verdict and explanation versus parent stress context", "role": "Required", "role_reason": "This condition connects The existing subclaim, verdict and explanation versus parent stress context with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for The existing subclaim, verdict and explanation versus parent stress context must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: The selection has no separate score, status or assessment axes. '?' is not replaced with another grade or the parent score. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The selection is treatment of depressive or anxiety disorders, and the original subclaim verdict is '?'. The original explanation that the main populations were healthy students and nurses, not patients in diagnosed-disorder treatment trials, is retained. Parent C50 concerns nonclinical stress.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The selection has no separate score, status or assessment axes. '?' is not replaced with another grade or the parent score.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The selection has no separate score, status or assessment axes. '?' is not replaced with another grade or the parent score." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "How do diagnosed patients differ from nonclinical samples?", "needed": "Diagnosis, eligibility, baseline severity and patient denominators", "role": "Required", "role_reason": "This condition connects Diagnosis, eligibility, baseline severity and patient denominators with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosis, eligibility, baseline severity and patient denominators must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Diagnosis, eligibility, severity and direct treatment denominators for the selected disorders are unlinked in current stored material. Working in psychiatry or having measured mental symptoms is not converted into a diagnosed-patient population. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original explanation lists nonclinical studies in 120 healthy university students, 75/83 nursing students and 70 psychiatric nurses, distinguishing them from treatment trials in psychiatric patients.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Diagnosis, eligibility, severity and direct treatment denominators for the selected disorders are unlinked in current stored material. Working in psychiatry or having measured mental symptoms is not converted into a diagnosed-patient population.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Diagnosis, eligibility, severity and direct treatment denominators for the selected disorders are unlinked in current stored material. Working in psychiatry or having measured mental symptoms is not converted into a diagnosed-patient population." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Were treatment outcomes for each disorder verified?", "needed": "Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions", "role": "Required", "role_reason": "This condition connects Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Direct treatment outcomes, remission, function and prespecified assessment instruments for each diagnosis are unverified. General mental-symptom results do not fill these gaps. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The Korean selection lists depression and anxiety disorders in parallel, while the original English wording is depressive or anxiety disorders.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct treatment outcomes, remission, function and prespecified assessment instruments for each diagnosis are unverified. General mental-symptom results do not fill these gaps.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct treatment outcomes, remission, function and prespecified assessment instruments for each diagnosis are unverified. General mental-symptom results do not fill these gaps." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Was the combined program evaluated as treatment in diagnosed patients?", "needed": "Program components, existing treatment, instructors, exposure and adherence", "role": "Required", "role_reason": "This condition connects Program components, existing treatment, instructors, exposure and adherence with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Program components, existing treatment, instructors, exposure and adherence must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: The relevant intervention, existing treatment, actual exposure, adherence and evaluation for treatment purposes in diagnosed patients are unlinked in current stored material. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original laughter-yoga program includes clapping, breathing, movement and group participation. This sheet does not provide yoga or mental-health treatment methods.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The relevant intervention, existing treatment, actual exposure, adherence and evaluation for treatment purposes in diagnosed patients are unlinked in current stored material.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The relevant intervention, existing treatment, actual exposure, adherence and evaluation for treatment purposes in diagnosed patients are unlinked in current stored material." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "Are parent controls controls for disorder treatment?", "needed": "Treatment comparators, active social controls and matched contact and expectations", "role": "Required", "role_reason": "This condition connects Treatment comparators, active social controls and matched contact and expectations with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Treatment comparators, active social controls and matched contact and expectations must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Treatment comparators, contact, expectations and concurrent-treatment correspondence in diagnosed patients are unverified. Video findings are not reassigned as confirmation of disorder treatment. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The parent explanation retains no-intervention controls, insufficient active social controls and combined effects as limitations. Fujisawa's humorous video and reading are separate acute nonclinical comparators.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Treatment comparators, contact, expectations and concurrent-treatment correspondence in diagnosed patients are unverified. Video findings are not reassigned as confirmation of disorder treatment.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Treatment comparators, contact, expectations and concurrent-treatment correspondence in diagnosed patients are unverified. Video findings are not reassigned as confirmation of disorder treatment." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are PSS, GHQ and burnout findings diagnosed-treatment outcomes?", "needed": "Nonclinical nurses' stress measures versus diagnosed-disorder treatment", "role": "Required", "role_reason": "This condition connects Nonclinical nurses' stress measures versus diagnosed-disorder treatment with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Nonclinical nurses' stress measures versus diagnosed-disorder treatment must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: These values are not used as depression/anxiety treatment effects, remission or patient denominators. Psychiatric nurses are not psychiatric patients. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Original parent results are retained: 70 participants, all completing at 35 versus 35, PSS/GHQ/burnout after 8 sessions, and PSS F(1,68)=251.56, P<.001, partial eta-squared=.787.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "These values are not used as depression/anxiety treatment effects, remission or patient denominators. Psychiatric nurses are not psychiatric patients.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "These values are not used as depression/anxiety treatment effects, remission or patient denominators. Psychiatric nurses are not psychiatric patients." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What context do well-being, PSS and conflicting statistics provide?", "needed": "Nonclinical endpoints, abstract/main-text tests and prespecification", "role": "Required", "role_reason": "This condition connects Nonclinical endpoints, abstract/main-text tests and prespecification with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Nonclinical endpoints, abstract/main-text tests and prespecification must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: The conflict is not newly resolved or reassigned as a disorder-treatment effect. The relevant diagnoses and direct outcomes are unlinked in the current stored summary. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original account retains 83 analyzed, 41 versus 42, coexisting abstract between-arm null and main-text multivariate F=10.69, P<.001, and retrospective registration.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The conflict is not newly resolved or reassigned as a disorder-treatment effect. The relevant diagnoses and direct outcomes are unlinked in the current stored summary.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The conflict is not newly resolved or reassigned as a disorder-treatment effect. The relevant diagnoses and direct outcomes are unlinked in the current stored summary." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Does a positive mental-symptom result establish treatment effects in diagnosed patients?", "needed": "Mental-symptom instruments, populations and evaluation for treatment purposes", "role": "Required", "role_reason": "This condition connects Mental-symptom instruments, populations and evaluation for treatment purposes with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Mental-symptom instruments, populations and evaluation for treatment purposes must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Positive mental-symptom findings are not converted into depression/anxiety diagnosis, treatment effects or remission. Instruments, original estimates and diagnostic data are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S03" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Positive mental-symptom findings in 75 first-year nursing students are retained separately from mixed cortisol findings.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Positive mental-symptom findings are not converted into depression/anxiety diagnosis, treatment effects or remission. Instruments, original estimates and diagnostic data are unverified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Positive mental-symptom findings are not converted into depression/anxiety diagnosis, treatment effects or remission. Instruments, original estimates and diagnostic data are unverified." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Do cortisol and DHEA establish disorder treatment?", "needed": "Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment", "role": "Required", "role_reason": "This condition connects Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Biomarker changes are not reassigned as depression treatment, anxiety-disorder remission or confirmation of mechanism. Direct outcomes for the selected treatment are unverified in current material. This records needed materials; no new research was executed.", "current_reports": [ "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Ozturk's between-arm cortisol positivity in 3 of 8 sessions and Fujisawa's time change, video-related change and null DHEA finding are retained.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Biomarker changes are not reassigned as depression treatment, anxiety-disorder remission or confirmation of mechanism. Direct outcomes for the selected treatment are unverified in current material.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Biomarker changes are not reassigned as depression treatment, anxiety-disorder remission or confirmation of mechanism. Direct outcomes for the selected treatment are unverified in current material." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Were allocation and blinding for the selected treatment verified?", "needed": "Diagnosed-patient allocation, concealment, independent assessment and analysis roles", "role": "Required", "role_reason": "This condition connects Diagnosed-patient allocation, concealment, independent assessment and analysis roles with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosed-patient allocation, concealment, independent assessment and analysis roles must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Allocation, concealment, assessor blinding and diagnostic/outcome assessment data for the selected treatment are unlinked in current material. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Randomized designs in the 4 reports and parent concerns about lack of blinding and combined instructor/assessor roles are preserved as nonclinical research context.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Allocation, concealment, assessor blinding and diagnostic/outcome assessment data for the selected treatment are unlinked in current material.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Allocation, concealment, assessor blinding and diagnostic/outcome assessment data for the selected treatment are unlinked in current material." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are nonclinical samples used as treatment-analysis denominators?", "needed": "Diagnosed-patient allocation, completion, analysis and missing-data handling", "role": "Required", "role_reason": "This condition connects Diagnosed-patient allocation, completion, analysis and missing-data handling with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosed-patient allocation, completion, analysis and missing-data handling must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: These counts are not used as disorder-treatment denominators. Direct-treatment analysis populations, missingness, baseline adjustment and repeated-data models are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The respective nonclinical labels are retained: all 70 completing, 83 analyzed, and total samples of 75 and 120.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "These counts are not used as disorder-treatment denominators. Direct-treatment analysis populations, missingness, baseline adjustment and repeated-data models are unverified.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "These counts are not used as disorder-treatment denominators. Direct-treatment analysis populations, missingness, baseline adjustment and repeated-data models are unverified." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Can treatment effects, confidence intervals and clinical meaning be determined?", "needed": "Diagnosis-specific between-arm effects, response, remission, function and sample planning", "role": "Required", "role_reason": "This condition connects Diagnosis-specific between-arm effects, response, remission, function and sample planning with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosis-specific between-arm effects, response, remission, function and sample planning must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Direct clinical effects, confidence intervals, response, remission, clinical-importance criteria and sample plans are unverified in current material. No new effects, intervals or grades are created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original selected verdict '?' and explanation that these were not diagnosed-patient treatment trials are retained.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct clinical effects, confidence intervals, response, remission, clinical-importance criteria and sample plans are unverified in current material. No new effects, intervals or grades are created.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct clinical effects, confidence intervals, response, remission, clinical-importance criteria and sample plans are unverified in current material. No new effects, intervals or grades are created." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Does nonclinical registration establish prespecification for the selected treatment?", "needed": "Each registration versus diagnosed-treatment plans", "role": "Required", "role_reason": "This condition connects Each registration versus diagnosed-treatment plans with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Each registration versus diagnosed-treatment plans must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Registration originals, protocols and analysis plans are unread and do not substitute for prespecification of the selected disorder treatment. Identifiers alone do not certify prespecification or treatment evidence. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Original records are retained: Bilgihan's NCT07015372 schedule-consistency concerns, Yaş's retrospective NCT06175936 registration, Fujisawa's UMIN000019409 and Ozturk's unverified registration.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Registration originals, protocols and analysis plans are unread and do not substitute for prespecification of the selected disorder treatment. Identifiers alone do not certify prespecification or treatment evidence.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration originals, protocols and analysis plans are unread and do not substitute for prespecification of the selected disorder treatment. Identifiers alone do not certify prespecification or treatment evidence." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Is program duration a psychiatric-treatment duration?", "needed": "Diagnosed-treatment duration, persistence and function/relapse follow-up", "role": "Required", "role_reason": "This condition connects Diagnosed-treatment duration, persistence and function/relapse follow-up with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosed-treatment duration, persistence and function/relapse follow-up must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: These are not reassigned as psychiatric-treatment duration or dose. Long-term treatment, relapse, function and persistence after discontinuation are unlinked in current material. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original explanation records single-exposure, 5-week or 8-session nonclinical programs.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "These are not reassigned as psychiatric-treatment duration or dose. Long-term treatment, relapse, function and persistence after discontinuation are unlinked in current material.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "These are not reassigned as psychiatric-treatment duration or dose. Long-term treatment, relapse, function and persistence after discontinuation are unlinked in current material." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "What about existing mental-health treatment and concurrent factors?", "needed": "Existing treatment, changes, concurrent treatment and attribution of combined effects", "role": "Supplementary", "role_reason": "This condition connects Existing treatment, changes, concurrent treatment and attribution of combined effects with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Existing treatment, changes, concurrent treatment and attribution of combined effects must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Direct-treatment medication, counseling, concurrent treatment, changes, adherence and lifestyle factors are unverified. No new instructions to replace or discontinue existing treatment are created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Combined social-participation and breathing effects in nonclinical groups provide parent-explanation context.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct-treatment medication, counseling, concurrent treatment, changes, adherence and lifestyle factors are unverified. No new instructions to replace or discontinue existing treatment are created.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct-treatment medication, counseling, concurrent treatment, changes, adherence and lifestyle factors are unverified. No new instructions to replace or discontinue existing treatment are created." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are shared reports independent replications of disorder treatment?", "needed": "Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials", "role": "Required", "role_reason": "This condition connects Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Unique trial, participant and independent-replication totals are unverified; direct diagnosed-treatment material is unlinked in current records. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The 4 reports are shared with the cortisol sheet, but are not counted as new independent trials. Agreement in nonclinical symptom direction is not converted into replicated confirmation of disorder treatment.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Unique trial, participant and independent-replication totals are unverified; direct diagnosed-treatment material is unlinked in current records.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Unique trial, participant and independent-replication totals are unverified; direct diagnosed-treatment material is unlinked in current records." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "What do support declarations and instructor/assessor roles establish?", "needed": "External funding, conflicts, training support and author/assessor roles", "role": "Required", "role_reason": "This condition connects External funding, conflicts, training support and author/assessor roles with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for External funding, conflicts, training support and author/assessor roles must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Declarations are not promoted to absence of all support, independent confirmation or completed current external comparison. Support evidence for the selected treatment is also unverified in current material. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Bilgihan's declaration of no external funding or conflicts is retained alongside combined instructor/assessor roles.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Declarations are not promoted to absence of all support, independent confirmation or completed current external comparison. Support evidence for the selected treatment is also unverified in current material.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Declarations are not promoted to absence of all support, independent confirmation or completed current external comparison. Support evidence for the selected treatment is also unverified in current material." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Were funding, support and conflicts in other reports verified?", "needed": "Report-specific funding, training support, employee authors and conflicts", "role": "Required", "role_reason": "This condition connects Report-specific funding, training support, employee authors and conflicts with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Report-specific funding, training support, employee authors and conflicts must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Evidence does not establish absence of support, independence, absence of employee authors or absence of conflicts. This records needed materials; no new research was executed.", "current_reports": [ "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The original record that funding in Yaş, Ozturk and Fujisawa was unable to be verified is retained.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Evidence does not establish absence of support, independence, absence of employee authors or absence of conflicts.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Evidence does not establish absence of support, independence, absence of employee authors or absence of conflicts." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "What is known about the selected treatment's safety and missingness?", "needed": "Diagnosed-patient harms, discontinuation, denominators, collection and timing", "role": "Supplementary", "role_reason": "This condition connects Diagnosed-patient harms, discontinuation, denominators, collection and timing with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosed-patient harms, discontinuation, denominators, collection and timing must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Diagnosed-patient harms evidence is unlinked in current material. Nonclinical completion, measures and biomarkers are not converted into treatment safety. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Original parent Unknown safety and insufficient arm-specific adverse-event and long-term safety numbers are retained.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Diagnosed-patient harms evidence is unlinked in current material. Nonclinical completion, measures and biomarkers are not converted into treatment safety.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Diagnosed-patient harms evidence is unlinked in current material. Nonclinical completion, measures and biomarkers are not converted into treatment safety." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What are the boundaries for long-term harms, vulnerable populations, alternative causes and guidance?", "needed": "Diagnosis-specific long-term harms, concurrent exposure and alternative causes", "role": "Supplementary", "role_reason": "This condition connects Diagnosis-specific long-term harms, concurrent exposure and alternative causes with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Diagnosis-specific long-term harms, concurrent exposure and alternative causes must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Diagnosis-specific long-term and vulnerable-population evidence, treatment-change-related harms and alternative causes are unverified. Unknown is not converted into safe or no events. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The parent safety explanation is retained as historical context, with no new yoga or mental-health treatment instructions.", "condition_status": "Unverified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Diagnosis-specific long-term and vulnerable-population evidence, treatment-change-related harms and alternative causes are unverified. Unknown is not converted into safe or no events.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Diagnosis-specific long-term and vulnerable-population evidence, treatment-change-related harms and alternative causes are unverified. Unknown is not converted into safe or no events." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "How are original languages, '?' verdict, parent axes and history retained?", "needed": "Separate preservation of parent/subclaim structures, wording and dates", "role": "Required", "role_reason": "This condition connects Separate preservation of parent/subclaim structures, wording and dates with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Separate preservation of parent/subclaim structures, wording and dates must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: Cortisol explanatory numbers, parent scores and axes and historical review are not inherited as new disorder-treatment values, current review or certification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "Parent C50, unspecified precision, Korean/English originals, evidence date 2026-09-07, an empty corrections list and empty deliberation are retained. Selected '?', the original explanation and absent separate score, status and axes are preserved.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Cortisol explanatory numbers, parent scores and axes and historical review are not inherited as new disorder-treatment values, current review or certification.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Cortisol explanatory numbers, parent scores and axes and historical review are not inherited as new disorder-treatment values, current review or certification." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "What was actually read from stored summaries and external materials?", "needed": "Report-specific originals, registration, plans, support and material-link status", "role": "Required", "role_reason": "This condition connects Report-specific originals, registration, plans, support and material-link status with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.", "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.", "criterion": "Material for Report-specific originals, registration, plans, support and material-link status must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.", "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.", "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.", "proposed_research": "Material needed: External papers, registration, protocols, analysis plans and support originals were unread and access was not attempted. URLs and historical verification statements are not promoted to current external reading or content verification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02", "S03", "S04" ], "existence": "Stored-summary statements were used; exact external-original content and acquisition are unverified. Currently preserved reports are not promoted to direct evidence of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external papers, registration, protocols, analysis plans and support disclosures unread", "observation": "The complete stored parent summary and bibliography were read for this production. Material links, summary reading and unread external materials are distinguished.", "condition_status": "Partly verified", "status_reason": "Known nonclinical information and gaps concerning the selected diagnosed-disorder treatment were distinguished and transferred from the stored summary. Detailed external material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "External papers, registration, protocols, analysis plans and support originals were unread and access was not attempted. URLs and historical verification statements are not promoted to current external reading or content verification.", "uncertainty": "External originals are unread and review of existing content remains incomplete. Gaps are not converted into treatment success, failure or absence of harm; original verdict '?' is retained. Original scores, axes and historical narratives are not used as new verdicts, current verification or independence certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External papers, registration, protocols, analysis plans and support originals were unread and access was not attempted. URLs and historical verification statements are not promoted to current external reading or content verification." } ], "reports": [ { "report_id": "S01", "title": "Bilgihan S, Dost A. The effect of laughter yoga on the general health status, perceived stress and burnout levels of psychiatric nurses: a randomized controlled study. Discover Psychology. 2026;6:200. DOI: 10.1007/s44202-026-00725-4.", "url": "https://doi.org/10.1007/s44202-026-00725-4", "report_type": "Randomized controlled trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified. Currently preserved reports are not linked as direct trials of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Nonclinical original report shared across sheets; unique counts and independence unverified", "independent_replication": "The parent and perceived-stress, cortisol and diagnosed-treatment questions share the four original reports. All four currently preserved reports provide nonclinical context and are not linked as direct treatment trials in patients with the selected diagnoses. Report-specific groups are retained, but unique trial, participant, independent-replication and event totals are unverified. Sheets, arms and sessions are not added as new treatment confirmation.", "observed_result": "PSS group-by-time F(1,68)=251.56, P<.001, partial eta-squared .787; trial and registration dates raised timing concerns", "result_level": "Nonclinical stress context: 70 psychiatric nurses, all completing at 35 versus 35, with PSS/GHQ/burnout after 8 sessions. Psychiatric nurses are not a diagnosed-patient sample; these statistics, denominators and durations are not reassigned as depression/anxiety treatment or remission.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original DOI 10.1007/s44202-026-00725-4, NCT07015372 and timing concerns. PMID/PMCID are unrecorded. No-external-funding/COI declarations and combined instructor/assessor roles provide nonclinical parent context, not current full-text/registration verification or certification of diagnosed-treatment evidence." } ], "links": [ { "label": "Official source", "url": "https://doi.org/10.1007/s44202-026-00725-4" } ] }, { "report_id": "S02", "title": "Yaş MA, et al. The effect of laughter yoga on well-being, perceived stress, and academic self-efficacy in nursing students: A randomized controlled trial. Appl Psychol Health Well Being. 2025;17:e12610. PMID: 39415513. PMCID: PMC11635907. DOI: 10.1111/aphw.12610.", "url": "https://pubmed.ncbi.nlm.nih.gov/39415513/", "report_type": "Randomized controlled trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified. Currently preserved reports are not linked as direct trials of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Nonclinical original report shared across sheets; unique counts and independence unverified", "independent_replication": "The parent and perceived-stress, cortisol and diagnosed-treatment questions share the four original reports. All four currently preserved reports provide nonclinical context and are not linked as direct treatment trials in patients with the selected diagnoses. Report-specific groups are retained, but unique trial, participant, independent-replication and event totals are unverified. Sheets, arms and sessions are not added as new treatment confirmation.", "observed_result": "A null between-group abstract statement coexisted with a multivariate interaction F=10.69, P<.001; registration was retrospective", "result_level": "Nonclinical well-being, PSS and self-efficacy context: 83 nursing students analyzed, 41 versus 42. Abstract between-arm null, main-text multivariate interaction and retrospective-registration statements are retained together. The conflict is not newly resolved or converted into a selected-disorder treatment effect.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 39415513, PMC11635907, DOI 10.1111/aphw.12610 and NCT06175936. Abstract/main-text conflict and retrospective registration are original narratives, not newly resolved. Support is unverified; these are not direct materials for treatment of the selected diagnoses." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/39415513/" } ] }, { "report_id": "S03", "title": "Ozturk FO, Tezel A. Effect of laughter yoga on mental symptoms and salivary cortisol levels in first-year nursing students: A randomized controlled trial. Int J Nurs Pract. 2021;27:e12924. PMID: 33580606. DOI: 10.1111/ijn.12924.", "url": "https://pubmed.ncbi.nlm.nih.gov/33580606/", "report_type": "Eight-session randomized controlled trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified. Currently preserved reports are not linked as direct trials of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Nonclinical original report shared across sheets; unique counts and independence unverified", "independent_replication": "The parent and perceived-stress, cortisol and diagnosed-treatment questions share the four original reports. All four currently preserved reports provide nonclinical context and are not linked as direct treatment trials in patients with the selected diagnoses. Report-specific groups are retained, but unique trial, participant, independent-replication and event totals are unverified. Sheets, arms and sessions are not added as new treatment confirmation.", "observed_result": "Mental symptoms favored intervention; cortisol was between-group positive in only 3 of 8 sessions", "result_level": "Nonclinical mental-symptom and cortisol context: 75 first-year nursing students over 8 sessions, with between-arm cortisol positivity in 3 of 8 sessions. Positive mental symptoms and session-specific biomarkers are distinguished and not reassigned as diagnosis, treatment or remission. Direct-treatment instruments, effects, CIs and patient denominators are unverified.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 33580606 and DOI 10.1111/ijn.12924. PMCID is unrecorded; registration and support are unverified. Nonclinical mental symptoms and session-specific cortisol are not reassigned as diagnosed-disorder treatment; external originals and plans were unread in this work." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/33580606/" } ] }, { "report_id": "S04", "title": "Fujisawa A, et al. Effect of laughter yoga on salivary cortisol and dehydroepiandrosterone among healthy university students: A randomized controlled trial. Complement Ther Clin Pract. 2018;32:6-11. PMID: 30057059. DOI: 10.1016/j.ctcp.2018.04.005.", "url": "https://pubmed.ncbi.nlm.nih.gov/30057059/", "report_type": "Three-arm laughter-yoga, humorous-video, and reading randomized trial", "existence": "The stored summary contains a bibliography; acquisition and reading of external originals are unverified. Currently preserved reports are not linked as direct trials of treatment for the selected diagnoses.", "acquired_read": "Stored summary read; external materials unread", "study_family": "Nonclinical original report shared across sheets; unique counts and independence unverified", "independent_replication": "The parent and perceived-stress, cortisol and diagnosed-treatment questions share the four original reports. All four currently preserved reports provide nonclinical context and are not linked as direct treatment trials in patients with the selected diagnoses. Report-specific groups are retained, but unique trial, participant, independent-replication and event totals are unverified. Sheets, arms and sessions are not added as new treatment confirmation.", "observed_result": "Cortisol changed over time, humorous video also changed it, and DHEA was null", "result_level": "Acute 3-arm laughter-yoga, video and reading comparison in 120 healthy university students. Original cortisol change over time, change with video and null DHEA findings are retained. Acute biomarker comparisons are not converted into diagnosed-patient treatment, long-term remission or confirmation of mechanism.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PMID 30057059, DOI 10.1016/j.ctcp.2018.04.005 and UMIN000019409. PMCID is unrecorded; support and exact comparative CIs are unverified. UMIN is not relabeled as NCT, and acute comparisons/identifiers are not treated as diagnosed-treatment evidence or current registration-content verification." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/30057059/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.", "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.", "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.", "Review incomplete": "User review pending.", "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.", "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.", "Not applicable": "Not used as a substitute for an evidence gap.", "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.", "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "The parent and perceived-stress, cortisol and diagnosed-treatment questions share the four original reports. All four currently preserved reports provide nonclinical context and are not linked as direct treatment trials in patients with the selected diagnoses. Report-specific groups are retained, but unique trial, participant, independent-replication and event totals are unverified. Sheets, arms and sessions are not added as new treatment confirmation." }, "history": [ { "date": "2026-10-19", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Reader pages and materials were prepared from the existing 22 items. No new clinical search, change in verification status or scoring was performed." } ], "language": "en", "translation_date": "2026-10-19" }