{
  "schema_version": "chamgap-public-criteria-1.0",
  "title": "Laughter Yoga × Treatment of Depressive or Anxiety Disorders · Evidence and Gaps Sheet",
  "language": "en",
  "translation_date": "2026-10-19",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "condition_origin": "Chamgap's own application conditions",
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.",
    "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.",
    "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.",
    "Review incomplete": "User review pending.",
    "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.",
    "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.",
    "Not applicable": "Not used as a substitute for an evidence gap.",
    "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.",
    "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade."
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "What are the selected treatment question and original verdict?",
      "needed": "The existing subclaim, verdict and explanation versus parent stress context",
      "role": "Required",
      "role_reason": "This condition connects The existing subclaim, verdict and explanation versus parent stress context with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for The existing subclaim, verdict and explanation versus parent stress context must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: The selection has no separate score, status or assessment axes. '?' is not replaced with another grade or the parent score. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "How do diagnosed patients differ from nonclinical samples?",
      "needed": "Diagnosis, eligibility, baseline severity and patient denominators",
      "role": "Required",
      "role_reason": "This condition connects Diagnosis, eligibility, baseline severity and patient denominators with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosis, eligibility, baseline severity and patient denominators must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Diagnosis, eligibility, severity and direct treatment denominators for the selected disorders are unlinked in current stored material. Working in psychiatry or having measured mental symptoms is not converted into a diagnosed-patient population. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Were treatment outcomes for each disorder verified?",
      "needed": "Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions",
      "role": "Required",
      "role_reason": "This condition connects Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosis-specific treatment aims, symptoms, remission, function and relapse definitions must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Direct treatment outcomes, remission, function and prespecified assessment instruments for each diagnosis are unverified. General mental-symptom results do not fill these gaps. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Was the combined program evaluated as treatment in diagnosed patients?",
      "needed": "Program components, existing treatment, instructors, exposure and adherence",
      "role": "Required",
      "role_reason": "This condition connects Program components, existing treatment, instructors, exposure and adherence with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Program components, existing treatment, instructors, exposure and adherence must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: The relevant intervention, existing treatment, actual exposure, adherence and evaluation for treatment purposes in diagnosed patients are unlinked in current stored material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "Are parent controls controls for disorder treatment?",
      "needed": "Treatment comparators, active social controls and matched contact and expectations",
      "role": "Required",
      "role_reason": "This condition connects Treatment comparators, active social controls and matched contact and expectations with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Treatment comparators, active social controls and matched contact and expectations must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Treatment comparators, contact, expectations and concurrent-treatment correspondence in diagnosed patients are unverified. Video findings are not reassigned as confirmation of disorder treatment. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "Are PSS, GHQ and burnout findings diagnosed-treatment outcomes?",
      "needed": "Nonclinical nurses' stress measures versus diagnosed-disorder treatment",
      "role": "Required",
      "role_reason": "This condition connects Nonclinical nurses' stress measures versus diagnosed-disorder treatment with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Nonclinical nurses' stress measures versus diagnosed-disorder treatment must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: These values are not used as depression/anxiety treatment effects, remission or patient denominators. Psychiatric nurses are not psychiatric patients. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "What context do well-being, PSS and conflicting statistics provide?",
      "needed": "Nonclinical endpoints, abstract/main-text tests and prespecification",
      "role": "Required",
      "role_reason": "This condition connects Nonclinical endpoints, abstract/main-text tests and prespecification with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Nonclinical endpoints, abstract/main-text tests and prespecification must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: The conflict is not newly resolved or reassigned as a disorder-treatment effect. The relevant diagnoses and direct outcomes are unlinked in the current stored summary. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "Does a positive mental-symptom result establish treatment effects in diagnosed patients?",
      "needed": "Mental-symptom instruments, populations and evaluation for treatment purposes",
      "role": "Required",
      "role_reason": "This condition connects Mental-symptom instruments, populations and evaluation for treatment purposes with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Mental-symptom instruments, populations and evaluation for treatment purposes must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Positive mental-symptom findings are not converted into depression/anxiety diagnosis, treatment effects or remission. Instruments, original estimates and diagnostic data are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Do cortisol and DHEA establish disorder treatment?",
      "needed": "Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment",
      "role": "Required",
      "role_reason": "This condition connects Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Separate evidence for biomarkers, symptoms and diagnosed-disorder treatment must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Biomarker changes are not reassigned as depression treatment, anxiety-disorder remission or confirmation of mechanism. Direct outcomes for the selected treatment are unverified in current material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Were allocation and blinding for the selected treatment verified?",
      "needed": "Diagnosed-patient allocation, concealment, independent assessment and analysis roles",
      "role": "Required",
      "role_reason": "This condition connects Diagnosed-patient allocation, concealment, independent assessment and analysis roles with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosed-patient allocation, concealment, independent assessment and analysis roles must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Allocation, concealment, assessor blinding and diagnostic/outcome assessment data for the selected treatment are unlinked in current material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Are nonclinical samples used as treatment-analysis denominators?",
      "needed": "Diagnosed-patient allocation, completion, analysis and missing-data handling",
      "role": "Required",
      "role_reason": "This condition connects Diagnosed-patient allocation, completion, analysis and missing-data handling with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosed-patient allocation, completion, analysis and missing-data handling must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: These counts are not used as disorder-treatment denominators. Direct-treatment analysis populations, missingness, baseline adjustment and repeated-data models are unverified. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Can treatment effects, confidence intervals and clinical meaning be determined?",
      "needed": "Diagnosis-specific between-arm effects, response, remission, function and sample planning",
      "role": "Required",
      "role_reason": "This condition connects Diagnosis-specific between-arm effects, response, remission, function and sample planning with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosis-specific between-arm effects, response, remission, function and sample planning must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Direct clinical effects, confidence intervals, response, remission, clinical-importance criteria and sample plans are unverified in current material. No new effects, intervals or grades are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Does nonclinical registration establish prespecification for the selected treatment?",
      "needed": "Each registration versus diagnosed-treatment plans",
      "role": "Required",
      "role_reason": "This condition connects Each registration versus diagnosed-treatment plans with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Each registration versus diagnosed-treatment plans must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Registration originals, protocols and analysis plans are unread and do not substitute for prespecification of the selected disorder treatment. Identifiers alone do not certify prespecification or treatment evidence. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Is program duration a psychiatric-treatment duration?",
      "needed": "Diagnosed-treatment duration, persistence and function/relapse follow-up",
      "role": "Required",
      "role_reason": "This condition connects Diagnosed-treatment duration, persistence and function/relapse follow-up with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosed-treatment duration, persistence and function/relapse follow-up must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: These are not reassigned as psychiatric-treatment duration or dose. Long-term treatment, relapse, function and persistence after discontinuation are unlinked in current material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What about existing mental-health treatment and concurrent factors?",
      "needed": "Existing treatment, changes, concurrent treatment and attribution of combined effects",
      "role": "Supplementary",
      "role_reason": "This condition connects Existing treatment, changes, concurrent treatment and attribution of combined effects with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Existing treatment, changes, concurrent treatment and attribution of combined effects must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Direct-treatment medication, counseling, concurrent treatment, changes, adherence and lifestyle factors are unverified. No new instructions to replace or discontinue existing treatment are created. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are shared reports independent replications of disorder treatment?",
      "needed": "Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials",
      "role": "Required",
      "role_reason": "This condition connects Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Nonclinical reports and cohorts versus direct diagnosed-patient treatment trials must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Unique trial, participant and independent-replication totals are unverified; direct diagnosed-treatment material is unlinked in current records. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What do support declarations and instructor/assessor roles establish?",
      "needed": "External funding, conflicts, training support and author/assessor roles",
      "role": "Required",
      "role_reason": "This condition connects External funding, conflicts, training support and author/assessor roles with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for External funding, conflicts, training support and author/assessor roles must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Declarations are not promoted to absence of all support, independent confirmation or completed current external comparison. Support evidence for the selected treatment is also unverified in current material. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Were funding, support and conflicts in other reports verified?",
      "needed": "Report-specific funding, training support, employee authors and conflicts",
      "role": "Required",
      "role_reason": "This condition connects Report-specific funding, training support, employee authors and conflicts with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Report-specific funding, training support, employee authors and conflicts must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Evidence does not establish absence of support, independence, absence of employee authors or absence of conflicts. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What is known about the selected treatment's safety and missingness?",
      "needed": "Diagnosed-patient harms, discontinuation, denominators, collection and timing",
      "role": "Supplementary",
      "role_reason": "This condition connects Diagnosed-patient harms, discontinuation, denominators, collection and timing with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosed-patient harms, discontinuation, denominators, collection and timing must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Diagnosed-patient harms evidence is unlinked in current material. Nonclinical completion, measures and biomarkers are not converted into treatment safety. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What are the boundaries for long-term harms, vulnerable populations, alternative causes and guidance?",
      "needed": "Diagnosis-specific long-term harms, concurrent exposure and alternative causes",
      "role": "Supplementary",
      "role_reason": "This condition connects Diagnosis-specific long-term harms, concurrent exposure and alternative causes with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Diagnosis-specific long-term harms, concurrent exposure and alternative causes must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Diagnosis-specific long-term and vulnerable-population evidence, treatment-change-related harms and alternative causes are unverified. Unknown is not converted into safe or no events. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "How are original languages, '?' verdict, parent axes and history retained?",
      "needed": "Separate preservation of parent/subclaim structures, wording and dates",
      "role": "Required",
      "role_reason": "This condition connects Separate preservation of parent/subclaim structures, wording and dates with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Separate preservation of parent/subclaim structures, wording and dates must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: Cortisol explanatory numbers, parent scores and axes and historical review are not inherited as new disorder-treatment values, current review or certification. This records needed materials; no new research was executed."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What was actually read from stored summaries and external materials?",
      "needed": "Report-specific originals, registration, plans, support and material-link status",
      "role": "Required",
      "role_reason": "This condition connects Report-specific originals, registration, plans, support and material-link status with the selected diagnoses, populations, treatment aims, interventions, concurrent treatment, comparators, outcomes, timing, denominators, prespecification, analyses or harms, distinguishing nonclinical parent reports.",
      "application_exception": "Retain original subclaim '?', its explanation and absent separate score/status/axes. Do not inherit parent C50, the cortisol explanation's 46-level wording or parent axes. Healthy students, nurses, psychiatric workplaces, mental symptoms and biomarkers are not converted into diagnosed patients, treatment or remission. Gaps in currently preserved reports are not extended to absence of research across all external literature or treatment success/failure. No new effects, CIs, grades, clinical totals, safety/independence certification, treatment methods or instructions to change existing treatment are created.",
      "criterion": "Material for Report-specific originals, registration, plans, support and material-link status must be linked to the relevant diagnoses, treatment comparisons, outcomes and denominators, distinguishing currently stored nonclinical information from gaps in direct treatment evidence.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, exposure, comparisons, reports versus trials, endpoints, denominators and harms were referenced.",
      "condition_origin": "These are in-house application conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed individual content review.",
      "proposed_research": "Material needed: External papers, registration, protocols, analysis plans and support originals were unread and access was not attempted. URLs and historical verification statements are not promoted to current external reading or content verification. This records needed materials; no new research was executed."
    }
  ]
}