# 30% MVC handgrip × 24-hour ambulatory pressure: evidence checklist Verdict 3002 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-18 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: Farah randomized 72 treated participants with hypertension; Palmeira has 63 primary-care participants with hypertension; the 2024 report has 84 older home-training participants. Arm eligibility, baseline control, medication changes, comorbidities and outcome-specific analysis denominators are unverified. Do not add these different participant counts. - Ingredient, formulation and route: Isometric handgrip training referenced to maximal voluntary contraction (MVC). Distinguish supervised delivery from unsupervised home training. Supervisory contact, actual intensity, devices, adherence and component contributions are unverified. Do not transfer supervised results to home training. - Dose: Original representative study conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Actual exposure, adherence and discontinuation are unverified. Calculate no new total time/exposure and do not turn these into personal exercise/breathing procedures, medication reduction/replacement or treatment instructions. - Comparator: Distinguish Farah supervised, home and no-exercise 3-arm conditions. Original 5% MVC sham, no-exercise and aerobic controls concern different trial contexts; do not fill in the same comparator for every report. Arm contact, exposure, medication/lifestyle care and adjusted effects for specific comparisons are unverified. - Measured outcome: The selection is lower 24-hour ambulatory pressure. Preserve Farah null ambulatory SBP P=.650/DBP P=.340. Direct between-group effects, 95% CIs, denominators and test models are unverified. Office SBP P=.041/DBP P=.049 omnibus tests, central/home measurements and day/night outcomes are separate. Null does not become exact effect 0 or equivalence. - Duration: Key Farah and Palmeira trials span 12 weeks. Exact duration of 2024 home training, day/night definitions, measurement timing, post-training persistence and long-term harms/clinical events are unverified. Do not turn a 24-hour measurement window into training duration or long-term effects. - Questions outside this scope: Turning null ambulatory-pressure P into exact pairwise effects/CIs, exclusion of important benefits or equivalence; Copying null 24-hour averages into each day/night result or effect 0; Extending supervised signals into unsupervised home training, all-day pressure reduction or medication replacement; Turning null results into exact effect 0, equivalence or safety certification; Arbitrarily resolving figure/table arm-label inconsistencies or creating new numbers, CIs or totals; Using shared reports/participants, academic support or parent C with 50 points as new independence, precision or subclaim scores; Creating new exercise methods, breathing procedures, medication reduction/replacement or treatment instructions ## Checklist items ### N01 · Which 24-hour ambulatory-pressure claim is selected? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selection is lower 24-hour ambulatory pressure. Preserve original grade D and the note that key and later trials were null. The supervised office-SBP grade C signal is a separate question. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores. - Required materials and conditions: Selected claim, grade and note versus the office-pressure verdict - Materials to obtain first: Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores. - Further research: Material needed: Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed. - Conditions for verification: Material for Selected claim, grade and note versus the office-pressure verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Selected claim, grade and note versus the office-pressure verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N02 · What are Farah's ambulatory-pressure tests? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Farah has 72 participants, 3 arms and 12 weeks. Preserve null ambulatory SBP P=.650/DBP P=.340. Distinguish office P=.041/P=.049; P does not become an mmHg effect or CI. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed. - Required materials and conditions: Ambulatory SBP/DBP tests, original models and denominators - Materials to obtain first: Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed. - Further research: Material needed: Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Ambulatory SBP/DBP tests, original models and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Ambulatory SBP/DBP tests, original models and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N03 · Does null establish effect 0 or equivalence? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve original null records. Exact ambulatory between-group effects/CIs are absent; do not newly certify exclusion of important benefits, precise effect 0, equivalence or noninferiority. Do not fill in unrecorded parent precision. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins. - Required materials and conditions: Nonsignificance, precision and exclusion of important benefits - Materials to obtain first: Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins. - Further research: Material needed: Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins. This records needed materials; no new research was executed. - Conditions for verification: Material for Nonsignificance, precision and exclusion of important benefits must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Nonsignificance, precision and exclusion of important benefits with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N04 · Are 24-hour averages and day/night outcomes the same? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text records null 24-hour ambulatory pressure but lacks separate day/night definitions, between-group values, P and CIs. Do not copy overall null P into each day/night result or establish effect 0 in each period. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed. - Required materials and conditions: Overall averages, day/night definitions, measurement windows and analyses - Materials to obtain first: Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed. - Further research: Material needed: Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Overall averages, day/night definitions, measurement windows and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Overall averages, day/night definitions, measurement windows and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N05 · What were ambulatory devices and valid-data denominators? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original endpoint is 24-hour measurement, but device, interval, baseline/follow-up valid-day, missingness, day/night weighting and denominator details are absent. Do not treat all randomized participants as ambulatory-measurement completers. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions. - Required materials and conditions: Devices, measurement intervals, validity criteria, missingness and analyses - Materials to obtain first: Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions. - Further research: Material needed: Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Devices, measurement intervals, validity criteria, missingness and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Devices, measurement intervals, validity criteria, missingness and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N06 · What were ambulatory effects for supervised, home and no-exercise conditions? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Farah has supervised, home and no-exercise 3-arm conditions. Do not transfer ambulatory SBP P=.650/DBP P=.340 into identical estimates, CIs or equivalence for each pair. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified. - Required materials and conditions: Omnibus 3-arm tests versus specific pairwise comparisons - Materials to obtain first: Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified. - Further research: Material needed: Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Omnibus 3-arm tests versus specific pairwise comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Omnibus 3-arm tests versus specific pairwise comparisons with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N07 · Is the office signal an additional ambulatory-pressure effect? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve Farah office-SBP/DBP signals alongside null ambulatory pressure. Do not extend supervised office reductions into all-day pressure effects or subtract values across settings to create new effects. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed. - Required materials and conditions: Office/ambulatory settings and effects of interest in the same trial - Materials to obtain first: Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed. - Further research: Material needed: Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Office/ambulatory settings and effects of interest in the same trial must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Office/ambulatory settings and effects of interest in the same trial with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N08 · What is the scope of Palmeira's later null ambulatory result? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve Palmeira positive office-SBP interaction and null DBP/ambulatory pressure. Exact ambulatory values, P, CIs and time-specific denominators are absent; do not copy Farah P into this report. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed. - Required materials and conditions: Ambulatory measurement, averages and denominators versus office outcomes - Materials to obtain first: Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed. - Further research: Material needed: Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Ambulatory measurement, averages and denominators versus office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Ambulatory measurement, averages and denominators versus office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R02 ### N09 · Was large attrition obscured by ambulatory denominators? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Palmeira bibliography records 63 participants and large attrition. Do not treat all participants as completed ambulatory data at every time/day-night period or arbitrarily calculate randomized/completed differences. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed. - Required materials and conditions: Total participants versus endpoint completion, valid measurements and analysis populations - Materials to obtain first: Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed. - Further research: Material needed: Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Total participants versus endpoint completion, valid measurements and analysis populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Total participants versus endpoint completion, valid measurements and analysis populations with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R02 ### N10 · What were the original results in later home training? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The 2024 report is a randomized home-training trial in 84 older participants; preserve null 24-hour and between-group office pressure. Exact duration, denominators, effects/CIs and registration are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions. - Required materials and conditions: Older home-training participants and ambulatory/between-group office outcomes - Materials to obtain first: Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions. - Further research: Material needed: Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions. This records needed materials; no new research was executed. - Conditions for verification: Material for Older home-training participants and ambulatory/between-group office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Older home-training participants and ambulatory/between-group office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R03 ### N11 · Can home training, home pressure and ambulatory pressure be combined? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: In the 2024 report, home training is the delivery location and 24-hour is the measurement window. The original text does not combine office, home and ambulatory averages as one endpoint. Exact home-measurement effects are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed. - Required materials and conditions: Intervention delivery location versus outcome measurement setting - Materials to obtain first: Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed. - Further research: Material needed: Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Intervention delivery location versus outcome measurement setting with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N12 · Were figure/table inconsistencies resolved using ambulatory values? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text retains figure/table arm-label inconsistencies. Do not choose arm values outside the summary to create precise comparisons or establish how the inconsistencies relate to ambulatory tables. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run. - Required materials and conditions: Farah arm labels and missing original-value attribution - Materials to obtain first: Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run. - Further research: Material needed: Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run. This records needed materials; no new research was executed. - Conditions for verification: Material for Farah arm labels and missing original-value attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Farah arm labels and missing original-value attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01 ### N13 · Can short-term null results be extended to long-term, day/night or disease events? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Key Farah and Palmeira trials span 12 weeks; exact duration of the 2024 report is absent from the summary. Do not turn null 24-hour averages or office signals into long-term persistence, all day/night periods, disease-event or medication-replacement outcomes. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions. - Required materials and conditions: Intervention duration, persistence, day/night, events and medication outcomes - Materials to obtain first: Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions. - Further research: Material needed: Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Intervention duration, persistence, day/night, events and medication outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Intervention duration, persistence, day/night, events and medication outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N14 · Do repeated null results form a unique independent-trial total? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text describes repeated null home/ambulatory results; the same reports are shared by the parent verdict and both subclaims. Do not newly certify all conditions as identical independent replication or add 72, 63 and 84 participants. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified. - Required materials and conditions: Trials, reports, institutions, recruitment, controls, supervision and shared questions - Materials to obtain first: Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified. - Further research: Material needed: Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified. This records needed materials; no new research was executed. - Conditions for verification: Material for Trials, reports, institutions, recruitment, controls, supervision and shared questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Trials, reports, institutions, recruitment, controls, supervision and shared questions with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N15 · Who were the participants and what was their medication status? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Farah randomized 72 treated participants with hypertension; Palmeira concerns primary-care hypertension; the 2024 report concerns older home-training participants. Original counts and representative information do not establish identical populations. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. - Required materials and conditions: Diagnosis, baseline control, medication, age, comorbidities and eligibility - Materials to obtain first: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. - Further research: Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed. - Conditions for verification: Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N16 · Are representative training conditions instructions? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original representative conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Preserve them as study identifiers; actual intensity and adherence are unverified. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. - Required materials and conditions: Original intensity, exposure, delivery and actual adherence - Materials to obtain first: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. - Further research: Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed. - Conditions for verification: Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original intensity, exposure, delivery and actual adherence with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N17 · Were different comparators distinguished? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text distinguishes trials of supervised/home training with 5% MVC sham, no-exercise and aerobic controls. Do not fill in the same comparator/blinding conditions for all reports. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. - Required materials and conditions: Sham, no-exercise and aerobic controls and effects of interest - Materials to obtain first: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. - Further research: Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed. - Conditions for verification: Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Sham, no-exercise and aerobic controls and effects of interest with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N18 · Were concurrent medication, activity and supervisory contact verified? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text records treated participants and supervised/home conditions. Medication types, doses, changes, baseline activity, premeasurement conditions, contact and actual exposure details are absent. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. - Required materials and conditions: Concurrent treatment, changes, actual exposure, measurement conditions and attribution - Materials to obtain first: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. - Further research: Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed. - Conditions for verification: Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N19 · Were randomization, blinding, measurement and timing verified? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original evidence labels randomized trials, but allocation, concealment, evaluators, standardized measurement, prospective planning, multiple time points and detailed attrition are absent from summaries. Preserve original B2 and small-sample/attrition limitations. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. - Required materials and conditions: Allocation, concealment, evaluators, standardized measurement, planning and missingness - Materials to obtain first: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. - Further research: Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed. - Conditions for verification: Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N20 · Are registration identifiers equivalent to reading original plans? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Farah NCT02348138 and Palmeira NCT03216317 are original identifiers; registration for the 2024 report is unverified. PMCID is preserved in the bibliography; external registration, plans, full texts and prospective-status comparisons were unread this run. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. - Required materials and conditions: Registration, paper linkage, changes, protocols, SAPs and planned endpoints - Materials to obtain first: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. - Further research: Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed. - Conditions for verification: Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N21 · What were funding, products, employee authors and design/analysis roles? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve Farah public/academic support, Palmeira public primary-care support and the 2024 report's academic support. Public/academic wording or parent I2 does not become new certification of overall independence. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. - Required materials and conditions: Financial/device/product support, author affiliations and design/analysis/publication control - Materials to obtain first: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. - Further research: Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed. - Conditions for verification: Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N22 · Were pain, exercise pressure and vulnerable-group harms verified? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Original safety text records hand/arm pain, pressure rises during breath-holding/Valsalva and uncontrolled-hypertension/cardiovascular-disease boundaries. Trial-specific harm events, exposure, denominators and collection are absent from summaries. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. - Required materials and conditions: Events, affected people, arm denominators, exposure, collection, stopping and follow-up - Materials to obtain first: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. - Further research: Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N23 · Are subclaim grades the same as parent scores and axes? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Supervised office subclaim C and ambulatory subclaim D have no individual score, status or axes. Preserve parent C with 50 points, caution, B/S/R1/I2/EX/B2 and unrecorded precision as parent context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. - Required materials and conditions: Absent subclaim score/status/axes versus the parent verdict - Materials to obtain first: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. - Further research: Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed. - Conditions for verification: Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Absent subclaim score/status/axes versus the parent verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N24 · How are representative information and both languages preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve complete bilingual texts and representative information. Representative 72 participants, 12 weeks, no exercise and office/central/ambulatory labels do not automatically apply to 63 or 84 participants, all day/night/home outcomes or each arm. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. - Required materials and conditions: Report-specific populations, supervision, measurement settings, outcomes, timing and denominators - Materials to obtain first: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. - Further research: Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed. - Conditions for verification: Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N25 · How are actual reading and report/material counts distinguished? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The complete parent JSON was read for production. Historical verification, separation and cross-checks remain historical records; external materials are unread. Report/material counts do not count acquired papers, independent trials, participants or quality scores. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. - Required materials and conditions: Stored summaries, external reading and trial/report/cohort relationships - Materials to obtain first: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. - Further research: Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed. - Conditions for verification: Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Stored summaries, external reading and trial/report/cohort relationships with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N26 · What are the evidence date and correction history? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve original evidence date 2026-09-07 and empty correction/deliberation records. Figure/table inconsistencies do not justify inventing corrections or turning production dates into evidence-verification dates. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. - Required materials and conditions: Original date, empty correction/deliberation records, production timing and original URLs - Materials to obtain first: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. - Further research: Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed. - Conditions for verification: Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original date, empty correction/deliberation records, production timing and original URLs with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ### N27 · How will new materials and changed questions be updated? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve original materials, conditions and observations. New materials are linked to supervision/controls, measurement settings, denominators, endpoints/timing/day-night, related reports and subclaim scope; no new lookup or reassessment occurred this run. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. - Required materials and conditions: Evidence updates, criteria revisions and original-verdict changes - Materials to obtain first: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. - Further research: Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Evidence updates, criteria revisions and original-verdict changes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries. - Application exceptions: Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: R01, R02, R03 ## Evidence and sources ### R01 Farah BQ, et al. Supervised, but Not Home-Based, Isometric Training Improves Brachial and Central Blood Pressure in Medicated Hypertensive Patients. Front Physiol. 2018;9:961. PMID: 30083107. PMCID: PMC6065303. DOI: 10.3389/fphys.2018.00961. [PubMed](https://pubmed.ncbi.nlm.nih.gov/30083107/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: Office SBP P=.041 and DBP P=.049; ambulatory SBP P=.650 and DBP P=.340 Record level: Medicated hypertension, 72 randomized, 12 weeks and supervised/home/no-exercise 3-arm conditions. Preserve null ambulatory SBP P=.650/DBP P=.340; direct effects, 95% CIs, valid-measurement denominators and test models are unverified. Distinguish office SBP P=.041/DBP P=.049 omnibus tests and do not arbitrarily resolve figure/table arm-label inconsistencies. Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies. | ### R02 Palmeira AC, et al. Effects of isometric handgrip training on blood pressure among hypertensive patients seen within public primary healthcare: a randomized controlled trial. Sao Paulo Med J. 2021;139:648-656. PMID: 34787298. PMCID: PMC9634841. DOI: 10.1590/1516-3180.2020.0796.R1.22042021. [PubMed](https://pubmed.ncbi.nlm.nih.gov/34787298/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: Office SBP interaction positive; DBP and ambulatory pressure null Record level: Distinguish null ambulatory pressure in the 63-participant, 12-week randomized primary-care hypertension trial from positive office-SBP interaction and null DBP. Exact ambulatory measurement windows, averages, effects/CIs, P, arm/time denominators, large attrition and missing-data handling are unverified. Do not copy P from the key trial. Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans. | ### R03 Home-based isometric handgrip training in older adults with hypertension. J Am Geriatr Soc. 2024. PMID: 39392028. DOI: 10.1111/jgs.19213. [PubMed](https://pubmed.ncbi.nlm.nih.gov/39392028/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: 24-hour ambulatory and between-group office pressure were null Record level: Preserve null 24-hour and between-group office pressure in the 2024 report of 84 older home-training participants. This does not replicate supervised effects under the same conditions; exact duration, comparator, effects/CIs, P and arm denominators are unverified. Independent replication: Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. | | External abstract | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. | | External full text | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. | | Protocol and analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Partly verified: Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified - Unverified: Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety - Review incomplete: Awaiting user review - Met: Use only within the relevant condition's scope after user review; no automatic display in this preparation - Not reported: Distinguish only within materials actually read; do not turn unread external materials into unreported findings - Inaccessible: Not applied during this preparation because actual access was not tested - Not applicable: Use with a reason for non-applicability based on an explicit question boundary - Conflicting data: Judge after actual material comparison; review was not performed during this preparation - Insufficient evidence for the conditions: Do not use as a clinical grade encompassing currently unread materials ## Change history 2026-10-18 · Public page/materials 1.0. Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.