{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v3002-s1",
  "verdict_number": "3002",
  "title": "30% MVC handgrip × 24-hour ambulatory pressure: evidence checklist",
  "view_version": "1.0",
  "view_created_date": "2026-10-18",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "Farah randomized 72 treated participants with hypertension; Palmeira has 63 primary-care participants with hypertension; the 2024 report has 84 older home-training participants. Arm eligibility, baseline control, medication changes, comorbidities and outcome-specific analysis denominators are unverified. Do not add these different participant counts.",
    "intervention": "Isometric handgrip training referenced to maximal voluntary contraction (MVC). Distinguish supervised delivery from unsupervised home training. Supervisory contact, actual intensity, devices, adherence and component contributions are unverified. Do not transfer supervised results to home training.",
    "dose": "Original representative study conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Actual exposure, adherence and discontinuation are unverified. Calculate no new total time/exposure and do not turn these into personal exercise/breathing procedures, medication reduction/replacement or treatment instructions.",
    "comparator": "Distinguish Farah supervised, home and no-exercise 3-arm conditions. Original 5% MVC sham, no-exercise and aerobic controls concern different trial contexts; do not fill in the same comparator for every report. Arm contact, exposure, medication/lifestyle care and adjusted effects for specific comparisons are unverified.",
    "endpoint": "The selection is lower 24-hour ambulatory pressure. Preserve Farah null ambulatory SBP P=.650/DBP P=.340. Direct between-group effects, 95% CIs, denominators and test models are unverified. Office SBP P=.041/DBP P=.049 omnibus tests, central/home measurements and day/night outcomes are separate. Null does not become exact effect 0 or equivalence.",
    "duration": "Key Farah and Palmeira trials span 12 weeks. Exact duration of 2024 home training, day/night definitions, measurement timing, post-training persistence and long-term harms/clinical events are unverified. Do not turn a 24-hour measurement window into training duration or long-term effects.",
    "excluded_extensions": [
      "Turning null ambulatory-pressure P into exact pairwise effects/CIs, exclusion of important benefits or equivalence",
      "Copying null 24-hour averages into each day/night result or effect 0",
      "Extending supervised signals into unsupervised home training, all-day pressure reduction or medication replacement",
      "Turning null results into exact effect 0, equivalence or safety certification",
      "Arbitrarily resolving figure/table arm-label inconsistencies or creating new numbers, CIs or totals",
      "Using shared reports/participants, academic support or parent C with 50 points as new independence, precision or subclaim scores",
      "Creating new exercise methods, breathing procedures, medication reduction/replacement or treatment instructions"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which 24-hour ambulatory-pressure claim is selected?",
      "needed": "Selected claim, grade and note versus the office-pressure verdict",
      "role": "Required",
      "role_reason": "This condition connects Selected claim, grade and note versus the office-pressure verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Selected claim, grade and note versus the office-pressure verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selection is lower 24-hour ambulatory pressure. Preserve original grade D and the note that key and later trials were null. The supervised office-SBP grade C signal is a separate question.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "What are Farah's ambulatory-pressure tests?",
      "needed": "Ambulatory SBP/DBP tests, original models and denominators",
      "role": "Required",
      "role_reason": "This condition connects Ambulatory SBP/DBP tests, original models and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Ambulatory SBP/DBP tests, original models and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Farah has 72 participants, 3 arms and 12 weeks. Preserve null ambulatory SBP P=.650/DBP P=.340. Distinguish office P=.041/P=.049; P does not become an mmHg effect or CI.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Does null establish effect 0 or equivalence?",
      "needed": "Nonsignificance, precision and exclusion of important benefits",
      "role": "Required",
      "role_reason": "This condition connects Nonsignificance, precision and exclusion of important benefits with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Nonsignificance, precision and exclusion of important benefits must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original null records. Exact ambulatory between-group effects/CIs are absent; do not newly certify exclusion of important benefits, precise effect 0, equivalence or noninferiority. Do not fill in unrecorded parent precision.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are 24-hour averages and day/night outcomes the same?",
      "needed": "Overall averages, day/night definitions, measurement windows and analyses",
      "role": "Required",
      "role_reason": "This condition connects Overall averages, day/night definitions, measurement windows and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Overall averages, day/night definitions, measurement windows and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original text records null 24-hour ambulatory pressure but lacks separate day/night definitions, between-group values, P and CIs. Do not copy overall null P into each day/night result or establish effect 0 in each period.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What were ambulatory devices and valid-data denominators?",
      "needed": "Devices, measurement intervals, validity criteria, missingness and analyses",
      "role": "Required",
      "role_reason": "This condition connects Devices, measurement intervals, validity criteria, missingness and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Devices, measurement intervals, validity criteria, missingness and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original endpoint is 24-hour measurement, but device, interval, baseline/follow-up valid-day, missingness, day/night weighting and denominator details are absent. Do not treat all randomized participants as ambulatory-measurement completers.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "What were ambulatory effects for supervised, home and no-exercise conditions?",
      "needed": "Omnibus 3-arm tests versus specific pairwise comparisons",
      "role": "Required",
      "role_reason": "This condition connects Omnibus 3-arm tests versus specific pairwise comparisons with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Omnibus 3-arm tests versus specific pairwise comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Farah has supervised, home and no-exercise 3-arm conditions. Do not transfer ambulatory SBP P=.650/DBP P=.340 into identical estimates, CIs or equivalence for each pair.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Is the office signal an additional ambulatory-pressure effect?",
      "needed": "Office/ambulatory settings and effects of interest in the same trial",
      "role": "Required",
      "role_reason": "This condition connects Office/ambulatory settings and effects of interest in the same trial with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Office/ambulatory settings and effects of interest in the same trial must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve Farah office-SBP/DBP signals alongside null ambulatory pressure. Do not extend supervised office reductions into all-day pressure effects or subtract values across settings to create new effects.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What is the scope of Palmeira's later null ambulatory result?",
      "needed": "Ambulatory measurement, averages and denominators versus office outcomes",
      "role": "Required",
      "role_reason": "This condition connects Ambulatory measurement, averages and denominators versus office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Ambulatory measurement, averages and denominators versus office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve Palmeira positive office-SBP interaction and null DBP/ambulatory pressure. Exact ambulatory values, P, CIs and time-specific denominators are absent; do not copy Farah P into this report.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Was large attrition obscured by ambulatory denominators?",
      "needed": "Total participants versus endpoint completion, valid measurements and analysis populations",
      "role": "Required",
      "role_reason": "This condition connects Total participants versus endpoint completion, valid measurements and analysis populations with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Total participants versus endpoint completion, valid measurements and analysis populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Palmeira bibliography records 63 participants and large attrition. Do not treat all participants as completed ambulatory data at every time/day-night period or arbitrarily calculate randomized/completed differences.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "What were the original results in later home training?",
      "needed": "Older home-training participants and ambulatory/between-group office outcomes",
      "role": "Required",
      "role_reason": "This condition connects Older home-training participants and ambulatory/between-group office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Older home-training participants and ambulatory/between-group office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The 2024 report is a randomized home-training trial in 84 older participants; preserve null 24-hour and between-group office pressure. Exact duration, denominators, effects/CIs and registration are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "Can home training, home pressure and ambulatory pressure be combined?",
      "needed": "Intervention delivery location versus outcome measurement setting",
      "role": "Required",
      "role_reason": "This condition connects Intervention delivery location versus outcome measurement setting with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "In the 2024 report, home training is the delivery location and 24-hour is the measurement window. The original text does not combine office, home and ambulatory averages as one endpoint. Exact home-measurement effects are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "Were figure/table inconsistencies resolved using ambulatory values?",
      "needed": "Farah arm labels and missing original-value attribution",
      "role": "Required",
      "role_reason": "This condition connects Farah arm labels and missing original-value attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Farah arm labels and missing original-value attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original text retains figure/table arm-label inconsistencies. Do not choose arm values outside the summary to create precise comparisons or establish how the inconsistencies relate to ambulatory tables.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "Can short-term null results be extended to long-term, day/night or disease events?",
      "needed": "Intervention duration, persistence, day/night, events and medication outcomes",
      "role": "Required",
      "role_reason": "This condition connects Intervention duration, persistence, day/night, events and medication outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Intervention duration, persistence, day/night, events and medication outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Key Farah and Palmeira trials span 12 weeks; exact duration of the 2024 report is absent from the summary. Do not turn null 24-hour averages or office signals into long-term persistence, all day/night periods, disease-event or medication-replacement outcomes.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "Do repeated null results form a unique independent-trial total?",
      "needed": "Trials, reports, institutions, recruitment, controls, supervision and shared questions",
      "role": "Required",
      "role_reason": "This condition connects Trials, reports, institutions, recruitment, controls, supervision and shared questions with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Trials, reports, institutions, recruitment, controls, supervision and shared questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original text describes repeated null home/ambulatory results; the same reports are shared by the parent verdict and both subclaims. Do not newly certify all conditions as identical independent replication or add 72, 63 and 84 participants.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "Who were the participants and what was their medication status?",
      "needed": "Diagnosis, baseline control, medication, age, comorbidities and eligibility",
      "role": "Required",
      "role_reason": "This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Farah randomized 72 treated participants with hypertension; Palmeira concerns primary-care hypertension; the 2024 report concerns older home-training participants. Original counts and representative information do not establish identical populations.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Are representative training conditions instructions?",
      "needed": "Original intensity, exposure, delivery and actual adherence",
      "role": "Supplementary",
      "role_reason": "This condition connects Original intensity, exposure, delivery and actual adherence with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original representative conditions are 30% MVC, 4 holds of 2 minutes, 3 times weekly. Preserve them as study identifiers; actual intensity and adherence are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "Were different comparators distinguished?",
      "needed": "Sham, no-exercise and aerobic controls and effects of interest",
      "role": "Required",
      "role_reason": "This condition connects Sham, no-exercise and aerobic controls and effects of interest with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original text distinguishes trials of supervised/home training with 5% MVC sham, no-exercise and aerobic controls. Do not fill in the same comparator/blinding conditions for all reports.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "Were concurrent medication, activity and supervisory contact verified?",
      "needed": "Concurrent treatment, changes, actual exposure, measurement conditions and attribution",
      "role": "Required",
      "role_reason": "This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original text records treated participants and supervised/home conditions. Medication types, doses, changes, baseline activity, premeasurement conditions, contact and actual exposure details are absent.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "Were randomization, blinding, measurement and timing verified?",
      "needed": "Allocation, concealment, evaluators, standardized measurement, planning and missingness",
      "role": "Required",
      "role_reason": "This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence labels randomized trials, but allocation, concealment, evaluators, standardized measurement, prospective planning, multiple time points and detailed attrition are absent from summaries. Preserve original B2 and small-sample/attrition limitations.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "Are registration identifiers equivalent to reading original plans?",
      "needed": "Registration, paper linkage, changes, protocols, SAPs and planned endpoints",
      "role": "Required",
      "role_reason": "This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Farah NCT02348138 and Palmeira NCT03216317 are original identifiers; registration for the 2024 report is unverified. PMCID is preserved in the bibliography; external registration, plans, full texts and prospective-status comparisons were unread this run.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "What were funding, products, employee authors and design/analysis roles?",
      "needed": "Financial/device/product support, author affiliations and design/analysis/publication control",
      "role": "Required",
      "role_reason": "This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve Farah public/academic support, Palmeira public primary-care support and the 2024 report's academic support. Public/academic wording or parent I2 does not become new certification of overall independence.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "Were pain, exercise pressure and vulnerable-group harms verified?",
      "needed": "Events, affected people, arm denominators, exposure, collection, stopping and follow-up",
      "role": "Supplementary",
      "role_reason": "This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original safety text records hand/arm pain, pressure rises during breath-holding/Valsalva and uncontrolled-hypertension/cardiovascular-disease boundaries. Trial-specific harm events, exposure, denominators and collection are absent from summaries.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "Are subclaim grades the same as parent scores and axes?",
      "needed": "Absent subclaim score/status/axes versus the parent verdict",
      "role": "Required",
      "role_reason": "This condition connects Absent subclaim score/status/axes versus the parent verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Supervised office subclaim C and ambulatory subclaim D have no individual score, status or axes. Preserve parent C with 50 points, caution, B/S/R1/I2/EX/B2 and unrecorded precision as parent context.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How are representative information and both languages preserved?",
      "needed": "Report-specific populations, supervision, measurement settings, outcomes, timing and denominators",
      "role": "Required",
      "role_reason": "This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve complete bilingual texts and representative information. Representative 72 participants, 12 weeks, no exercise and office/central/ambulatory labels do not automatically apply to 63 or 84 participants, all day/night/home outcomes or each arm.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How are actual reading and report/material counts distinguished?",
      "needed": "Stored summaries, external reading and trial/report/cohort relationships",
      "role": "Required",
      "role_reason": "This condition connects Stored summaries, external reading and trial/report/cohort relationships with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete parent JSON was read for production. Historical verification, separation and cross-checks remain historical records; external materials are unread. Report/material counts do not count acquired papers, independent trials, participants or quality scores.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "What are the evidence date and correction history?",
      "needed": "Original date, empty correction/deliberation records, production timing and original URLs",
      "role": "Required",
      "role_reason": "This condition connects Original date, empty correction/deliberation records, production timing and original URLs with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original evidence date 2026-09-07 and empty correction/deliberation records. Figure/table inconsistencies do not justify inventing corrections or turning production dates into evidence-verification dates.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "How will new materials and changed questions be updated?",
      "needed": "Evidence updates, criteria revisions and original-verdict changes",
      "role": "Required",
      "role_reason": "This condition connects Evidence updates, criteria revisions and original-verdict changes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.",
      "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.",
      "criterion": "Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserve original materials, conditions and observations. New materials are linked to supervision/controls, measurement settings, denominators, endpoints/timing/day-night, related reports and subclaim scope; no new lookup or reassessment occurred this run.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Farah BQ, et al. Supervised, but Not Home-Based, Isometric Training Improves Brachial and Central Blood Pressure in Medicated Hypertensive Patients. Front Physiol. 2018;9:961. PMID: 30083107. PMCID: PMC6065303. DOI: 10.3389/fphys.2018.00961.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/30083107/",
      "report_type": "Three-arm supervised, home, and no-exercise randomized trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Original report R01; unique counts and independent replication unverified",
      "independent_replication": "Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.",
      "observed_result": "Office SBP P=.041 and DBP P=.049; ambulatory SBP P=.650 and DBP P=.340",
      "result_level": "Medicated hypertension, 72 randomized, 12 weeks and supervised/home/no-exercise 3-arm conditions. Preserve null ambulatory SBP P=.650/DBP P=.340; direct effects, 95% CIs, valid-measurement denominators and test models are unverified. Distinguish office SBP P=.041/DBP P=.049 omnibus tests and do not arbitrarily resolve figure/table arm-label inconsistencies.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 30083107, PMCID PMC6065303, DOI 10.3389/fphys.2018.00961 and registration wording NCT02348138. External full text, registration and protocols/SAPs are unread; infer no new URLs, prospective status, registration changes or resolution of inconsistencies."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/30083107/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Palmeira AC, et al. Effects of isometric handgrip training on blood pressure among hypertensive patients seen within public primary healthcare: a randomized controlled trial. Sao Paulo Med J. 2021;139:648-656. PMID: 34787298. PMCID: PMC9634841. DOI: 10.1590/1516-3180.2020.0796.R1.22042021.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/34787298/",
      "report_type": "Twelve-week randomized controlled trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Original report R02; unique counts and independent replication unverified",
      "independent_replication": "Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.",
      "observed_result": "Office SBP interaction positive; DBP and ambulatory pressure null",
      "result_level": "Distinguish null ambulatory pressure in the 63-participant, 12-week randomized primary-care hypertension trial from positive office-SBP interaction and null DBP. Exact ambulatory measurement windows, averages, effects/CIs, P, arm/time denominators, large attrition and missing-data handling are unverified. Do not copy P from the key trial.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 34787298, PMCID PMC9634841, DOI 10.1590/1516-3180.2020.0796.R1.22042021 and registration wording NCT03216317. External full text, registration and protocols/SAPs are unread; identifiers/PMCID alone do not establish prospective status, reading or verified analysis plans."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/34787298/"
        }
      ]
    },
    {
      "report_id": "R03",
      "title": "Home-based isometric handgrip training in older adults with hypertension. J Am Geriatr Soc. 2024. PMID: 39392028. DOI: 10.1111/jgs.19213.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39392028/",
      "report_type": "Randomized home-training trial in older adults",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Original report R03; unique counts and independent replication unverified",
      "independent_replication": "Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals.",
      "observed_result": "24-hour ambulatory and between-group office pressure were null",
      "result_level": "Preserve null 24-hour and between-group office pressure in the 2024 report of 84 older home-training participants. This does not replicate supervised effects under the same conditions; exact duration, comparator, effects/CIs, P and arm denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading."
        },
        {
          "material_type": "Protocol and analysis plan",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": null,
          "qualification": "Preserve original PubMed URL, PMID 39392028 and DOI 10.1111/jgs.19213. PMCID and a separate registration annotation are unrecorded; original registration wording is unverified. Do not infer no registration, new identifiers/URLs, prospective status or original-text reading."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39392028/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified",
    "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety",
    "Review incomplete": "Awaiting user review",
    "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation",
    "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings",
    "Inaccessible": "Not applied during this preparation because actual access was not tested",
    "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary",
    "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation",
    "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials"
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Supervised office SBP and the separate ambulatory-pressure question share Farah, Palmeira and the 2024 home-training reports. Report/cohort relationships and unique-trial/participant totals are unverified. Multiple sheets, measures and report participants are not counted as new independent trials or participant totals."
  },
  "history": [
    {
      "date": "2026-10-18",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-18"
}