{ "schema_version": "chamgap-public-criteria-1.0", "title": "30% MVC handgrip × 24-hour ambulatory pressure: evidence checklist", "language": "en", "translation_date": "2026-10-18", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Partly verified": "Some information is present in the stored source, with detailed original materials still unverified; this does not mean review passed or clinical efficacy certified", "Unverified": "Detailed materials for the selected condition could not be established within the stored scope; this does not mean zero effect, zero studies or safety", "Review incomplete": "Awaiting user review", "Met": "Use only within the relevant condition's scope after user review; no automatic display in this preparation", "Not reported": "Distinguish only within materials actually read; do not turn unread external materials into unreported findings", "Inaccessible": "Not applied during this preparation because actual access was not tested", "Not applicable": "Use with a reason for non-applicability based on an explicit question boundary", "Conflicting data": "Judge after actual material comparison; review was not performed during this preparation", "Insufficient evidence for the conditions": "Do not use as a clinical grade encompassing currently unread materials" }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which 24-hour ambulatory-pressure claim is selected?", "needed": "Selected claim, grade and note versus the office-pressure verdict", "role": "Required", "role_reason": "This condition connects Selected claim, grade and note versus the office-pressure verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Selected claim, grade and note versus the office-pressure verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original 24-hour mean SBP/DBP, measurements, denominators, comparators, timing and direct effects/CIs are unverified. Create no new independent claims or scores. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "What are Farah's ambulatory-pressure tests?", "needed": "Ambulatory SBP/DBP tests, original models and denominators", "role": "Required", "role_reason": "This condition connects Ambulatory SBP/DBP tests, original models and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Ambulatory SBP/DBP tests, original models and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original models, group-by-time/specific comparison definitions, original 24-hour means, arm denominators, direct effects/CIs and measurement days are needed. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Does null establish effect 0 or equivalence?", "needed": "Nonsignificance, precision and exclusion of important benefits", "role": "Required", "role_reason": "This condition connects Nonsignificance, precision and exclusion of important benefits with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Nonsignificance, precision and exclusion of important benefits must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct effects/CIs, arm denominators, planned importance/success/equivalence margins and original power are needed. Calculate no new CIs or margins. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are 24-hour averages and day/night outcomes the same?", "needed": "Overall averages, day/night definitions, measurement windows and analyses", "role": "Required", "role_reason": "This condition connects Overall averages, day/night definitions, measurement windows and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Overall averages, day/night definitions, measurement windows and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Day/night and sleep definitions, valid measurements, time-specific denominators/weighting, original averages, specific comparisons/CIs and planned hierarchy are needed. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What were ambulatory devices and valid-data denominators?", "needed": "Devices, measurement intervals, validity criteria, missingness and analyses", "role": "Required", "role_reason": "This condition connects Devices, measurement intervals, validity criteria, missingness and analyses with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Devices, measurement intervals, validity criteria, missingness and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original devices, conditions, measurement days/frequency, validity criteria, time-specific denominators, missingness/stopping and analyses are needed. Provide no monitor-use or exercise instructions. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What were ambulatory effects for supervised, home and no-exercise conditions?", "needed": "Omnibus 3-arm tests versus specific pairwise comparisons", "role": "Required", "role_reason": "This condition connects Omnibus 3-arm tests versus specific pairwise comparisons with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Omnibus 3-arm tests versus specific pairwise comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Planned comparisons, adjusted models, original arm ambulatory values, denominators, direct effects/CIs and multiple comparisons are unverified. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "Is the office signal an additional ambulatory-pressure effect?", "needed": "Office/ambulatory settings and effects of interest in the same trial", "role": "Required", "role_reason": "This condition connects Office/ambulatory settings and effects of interest in the same trial with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Office/ambulatory settings and effects of interest in the same trial must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Setting-specific measurements, scales, denominators, baseline/follow-up and specific comparisons/CIs under the same model are needed. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What is the scope of Palmeira's later null ambulatory result?", "needed": "Ambulatory measurement, averages and denominators versus office outcomes", "role": "Required", "role_reason": "This condition connects Ambulatory measurement, averages and denominators versus office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Ambulatory measurement, averages and denominators versus office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original ambulatory measurements, averages, arm comparisons/CIs, P, denominators, baseline adjustment, planned analyses and missing-data records are needed. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "Was large attrition obscured by ambulatory denominators?", "needed": "Total participants versus endpoint completion, valid measurements and analysis populations", "role": "Required", "role_reason": "This condition connects Total participants versus endpoint completion, valid measurements and analysis populations with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Total participants versus endpoint completion, valid measurements and analysis populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original flow charts, arm/time denominators, completion/valid measurements, withdrawal reasons, ITT, missing-data handling and sensitivity records are needed. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "What were the original results in later home training?", "needed": "Older home-training participants and ambulatory/between-group office outcomes", "role": "Required", "role_reason": "This condition connects Older home-training participants and ambulatory/between-group office outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Older home-training participants and ambulatory/between-group office outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original home training, controls, exposure/adherence, duration, setting-specific effects/CIs, denominators and registration/plans are needed. Do not copy supervised results into these conditions. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Can home training, home pressure and ambulatory pressure be combined?", "needed": "Intervention delivery location versus outcome measurement setting", "role": "Required", "role_reason": "This condition connects Intervention delivery location versus outcome measurement setting with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Intervention delivery location versus outcome measurement setting must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original data separating delivery/supervision from measurement location, devices, schedules, timing, denominators and specific comparisons are needed. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Were figure/table inconsistencies resolved using ambulatory values?", "needed": "Farah arm labels and missing original-value attribution", "role": "Required", "role_reason": "This condition connects Farah arm labels and missing original-value attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Farah arm labels and missing original-value attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original tables, figures, arm keys/legends, analysis data, corrections and author explanations are needed. No external reading, resolution of inconsistencies or original-value changes occurred this run. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Can short-term null results be extended to long-term, day/night or disease events?", "needed": "Intervention duration, persistence, day/night, events and medication outcomes", "role": "Required", "role_reason": "This condition connects Intervention duration, persistence, day/night, events and medication outcomes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Intervention duration, persistence, day/night, events and medication outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Duration, post-training follow-up, original day/night values, arm denominators, important event/medication outcomes and direct effects/CIs are needed. Create no new medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Do repeated null results form a unique independent-trial total?", "needed": "Trials, reports, institutions, recruitment, controls, supervision and shared questions", "role": "Required", "role_reason": "This condition connects Trials, reports, institutions, recruitment, controls, supervision and shared questions with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Trials, reports, institutions, recruitment, controls, supervision and shared questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Trial, report, registration, institution/recruitment/participant, support, comparator, endpoint and duration links are needed. Keep unique-trial/participant totals unverified. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Who were the participants and what was their medication status?", "needed": "Diagnosis, baseline control, medication, age, comorbidities and eligibility", "role": "Required", "role_reason": "This condition connects Diagnosis, baseline control, medication, age, comorbidities and eligibility with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Diagnosis, baseline control, medication, age, comorbidities and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Diagnosis, baseline control, medication/changes, age, comorbidities, recruitment/exclusions and arm denominators are unverified. Do not extend this to untreated, other-patient or vulnerable populations. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are representative training conditions instructions?", "needed": "Original intensity, exposure, delivery and actual adherence", "role": "Supplementary", "role_reason": "This condition connects Original intensity, exposure, delivery and actual adherence with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Original intensity, exposure, delivery and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original devices, intensity measurement, exposure/sessions, supervision/contact, adherence and control records are needed. Calculate no new total time/exposure or exercise, breathing or treatment steps. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Were different comparators distinguished?", "needed": "Sham, no-exercise and aerobic controls and effects of interest", "role": "Required", "role_reason": "This condition connects Sham, no-exercise and aerobic controls and effects of interest with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Sham, no-exercise and aerobic controls and effects of interest must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific control intensity, exposure, contact, baseline adjustment, planned comparisons and denominators are unverified. Do not interchange comparator-specific effects. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Were concurrent medication, activity and supervisory contact verified?", "needed": "Concurrent treatment, changes, actual exposure, measurement conditions and attribution", "role": "Required", "role_reason": "This condition connects Concurrent treatment, changes, actual exposure, measurement conditions and attribution with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Concurrent treatment, changes, actual exposure, measurement conditions and attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm medication/changes, concurrent activity, adherence, measurement conditions, models, denominators and original effects are needed. Do not establish identical conditions or effects without medication. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Were randomization, blinding, measurement and timing verified?", "needed": "Allocation, concealment, evaluators, standardized measurement, planning and missingness", "role": "Required", "role_reason": "This condition connects Allocation, concealment, evaluators, standardized measurement, planning and missingness with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Allocation, concealment, evaluators, standardized measurement, planning and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original methods, measurement procedures, blinding, baseline adjustment/missingness, planned endpoints/comparisons/timing and analysis plans are needed. Create no official method-assessment pass or new grade. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are registration identifiers equivalent to reading original plans?", "needed": "Registration, paper linkage, changes, protocols, SAPs and planned endpoints", "role": "Required", "role_reason": "This condition connects Registration, paper linkage, changes, protocols, SAPs and planned endpoints with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Registration, paper linkage, changes, protocols, SAPs and planned endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original registration, changes, paper linkage, protocols/SAPs, planned endpoints, arm comparisons and denominators are needed. Identifiers, URLs and PMCID alone do not establish reading or prospective verification. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What were funding, products, employee authors and design/analysis roles?", "needed": "Financial/device/product support, author affiliations and design/analysis/publication control", "role": "Required", "role_reason": "This condition connects Financial/device/product support, author affiliations and design/analysis/publication control with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Financial/device/product support, author affiliations and design/analysis/publication control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Disclosures of financial/device/product support, company/author affiliations, design/analysis/publication roles and institutional, recruitment and report relationships are unread. Do not fill in no support or involvement. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Were pain, exercise pressure and vulnerable-group harms verified?", "needed": "Events, affected people, arm denominators, exposure, collection, stopping and follow-up", "role": "Supplementary", "role_reason": "This condition connects Events, affected people, arm denominators, exposure, collection, stopping and follow-up with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Events, affected people, arm denominators, exposure, collection, stopping and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Harm collection, severity/timing, events/affected people, denominators, actual exposure, stopping, medication/vulnerable groups and long-term data are needed. Null ambulatory pressure does not become no harm or safety certification. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are subclaim grades the same as parent scores and axes?", "needed": "Absent subclaim score/status/axes versus the parent verdict", "role": "Required", "role_reason": "This condition connects Absent subclaim score/status/axes versus the parent verdict with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Absent subclaim score/status/axes versus the parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Do not fill subclaims with parent scores/axes or turn unrecorded precision into default values, new scores or independence certification. Distinguish parent/subclaim application boundaries. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "How are representative information and both languages preserved?", "needed": "Report-specific populations, supervision, measurement settings, outcomes, timing and denominators", "role": "Required", "role_reason": "This condition connects Report-specific populations, supervision, measurement settings, outcomes, timing and denominators with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Report-specific populations, supervision, measurement settings, outcomes, timing and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific delivery, supervision, measurement settings, endpoints, timing, denominators and original English comparison materials are needed. No external English comparison or correction review was performed this run. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "How are actual reading and report/material counts distinguished?", "needed": "Stored summaries, external reading and trial/report/cohort relationships", "role": "Required", "role_reason": "This condition connects Stored summaries, external reading and trial/report/cohort relationships with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Stored summaries, external reading and trial/report/cohort relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original-material acquisition, actual reading and trial/report/cohort relationships are unverified. URLs/identifiers alone do not establish completed reading or unique-trial/participant totals. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "What are the evidence date and correction history?", "needed": "Original date, empty correction/deliberation records, production timing and original URLs", "role": "Required", "role_reason": "This condition connects Original date, empty correction/deliberation records, production timing and original URLs with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Original date, empty correction/deliberation records, production timing and original URLs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: When originals/corrections are acquired, preserve and link complete texts, events, versions and reasons. No original-verdict change or external lookup was performed this run. This records needed materials; no new research was executed." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "How will new materials and changed questions be updated?", "needed": "Evidence updates, criteria revisions and original-verdict changes", "role": "Required", "role_reason": "This condition connects Evidence updates, criteria revisions and original-verdict changes with selected ambulatory pressure, averages, day/night measures, devices, valid-data denominators, supervision, controls, analyses, persistence and harm boundaries.", "application_exception": "Preserve selected D and the note that key and later trials were null. Distinguish absent subclaim score/status/axes from parent C with 50 points. Null does not become precise effect 0 or equivalence; office signals do not become ambulatory effects. Do not merge day/night periods, measurement windows, controls or denominators or create new numbers, grades, independence/safety certification or exercise, medication or treatment instructions.", "criterion": "Material for Evidence updates, criteria revisions and original-verdict changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Updates must retain complete texts, criteria versions, events and reasons. Do not invent clinical calculations, effects/CIs, independence certification, exercise methods, pressure-medication reduction/replacement or treatment instructions. This records needed materials; no new research was executed." } ] }