# Supervised wall sits × lower resting SBP at 12 weeks Verdict 3000 · Evidence Check Stored-material review date: Not recorded Original evidence cut-off: 2026-09-07 Review-criteria version: 1.0 Public page/material preparation date: 2026-10-16 Clinical papers were not read directly; existing review summaries were checked. No new clinical-literature search was performed. Unverified does not mean that research is absent or that there is no effect. ## Assessment scope - Population: Cohen records 77 untreated adults aged 35–65 with hypertension, all completed. Arm denominators, diagnosis/baseline severity, eligibility/exclusions and measurement completeness are unverified. Decaux has a separate 30 participants; counts are not added. - Ingredient, formulation and route: Knee angle, intensity calibration and supervision belong to the original supervised isometric wall-sit conditions. Exact settings, actual delivery and adherence are unverified. This sheet describes research records and creates no personal exercise, breathing or treatment instructions. - Dose: Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose. - Comparator: Within Cohen’s 3 handgrip, wall-sit and no-exercise arms, the selected comparison is wall sit versus no exercise. Decaux’s 4-week wall-sit, low-intensity sham and no-exercise comparisons are separate. Arm denominators, contact, expectations, activity and exact comparator-specific contrasts are unverified. - Measured outcome: At 12 weeks, office resting SBP is 141.2→128.3 with wall sits versus 138.9→138.5 mmHg with no exercise. Distinguish original within-group changes -12.9/P<.001 and -0.4 from the historical simple difference -12.5. That simple difference is not an adjusted estimate; exact between-group 95% CIs, model and prospective hierarchy are unverified. The null between-group DBP result is separate. - Duration: Initial 12 weeks and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold refer to different times. The acute study bibliography, population and denominators are not linked. Do not extend this to long-term effects, treated people, other ages, medication replacement or cardiovascular events. - Questions outside this scope: Transferring within-group changes/P or a historical simple difference into adjusted between-group effects/CIs; Transferring later once-weekly maintenance into a minimum starting dose; Combining resting SBP, DBP and acute in-exercise pressure as one result; Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention; Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals; Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification; Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions ## Checklist items ### N01 · What is the selected 12-week resting-SBP question? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The selection is lower resting SBP after 12 weeks of supervised wall sits. Preserve subclaim C and the within-group -12.9 mmHg note. Parent grade C with 54 points is separate context. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: The subclaim has no score, status or axis fields. Do not fill them with parent values. - Required materials and conditions: Exact subclaim, grade/note and parent verdict - Materials to obtain first: The subclaim has no score, status or axis fields. Do not fill them with parent values. - Further research: Material needed: The subclaim has no score, status or axis fields. Do not fill them with parent values. This records needed materials; no new research was executed. - Conditions for verification: Material for Exact subclaim, grade/note and parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Exact subclaim, grade/note and parent verdict with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N02 · Which adults with hypertension participated? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Cohen records 77 untreated adults aged 35–65 with hypertension. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages. - Required materials and conditions: Diagnosis, age, medication status, baseline risk and eligibility - Materials to obtain first: Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages. - Further research: Material needed: Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages. This records needed materials; no new research was executed. - Conditions for verification: Material for Diagnosis, age, medication status, baseline risk and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Diagnosis, age, medication status, baseline risk and eligibility with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N03 · What was the supervised wall-sit intervention? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original text records angle, intensity and supervision as parts of supervised isometric wall sits. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions. - Required materials and conditions: Supervision, knee angle, intensity calibration, actual delivery and components - Materials to obtain first: Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions. - Further research: Material needed: Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Supervision, knee angle, intensity calibration, actual delivery and components must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Supervision, knee angle, intensity calibration, actual delivery and components with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N04 · How do initial training and maintenance differ? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose. - Required materials and conditions: Separate attribution of initial/maintenance schedules and analyses - Materials to obtain first: Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose. - Further research: Material needed: Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose. This records needed materials; no new research was executed. - Conditions for verification: Material for Separate attribution of initial/maintenance schedules and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Separate attribution of initial/maintenance schedules and analyses with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N05 · What were the actual comparators? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: 77 participants were assigned to 3 handgrip, wall-sit and no-exercise arms. Selected values describe wall sit versus no exercise. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention. - Required materials and conditions: Wall sit versus no exercise and the scope of the other exercise arm - Materials to obtain first: Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention. - Further research: Material needed: Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention. This records needed materials; no new research was executed. - Conditions for verification: Material for Wall sit versus no exercise and the scope of the other exercise arm must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Wall sit versus no exercise and the scope of the other exercise arm with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N06 · Does complete follow-up establish endpoint denominators? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve the original record that all 77 Cohen participants completed. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome. - Required materials and conditions: Overall allocation/completion versus arm denominators, missing measurements and analysis rules - Materials to obtain first: Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome. - Further research: Material needed: Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome. This records needed materials; no new research was executed. - Conditions for verification: Material for Overall allocation/completion versus arm denominators, missing measurements and analysis rules must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Overall allocation/completion versus arm denominators, missing measurements and analysis rules with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N07 · How was resting office SBP measured? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The endpoint is recorded as 12-week office resting blood pressure. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure. - Required materials and conditions: Resting conditions, equipment, repetitions, assessor and timing - Materials to obtain first: Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure. - Further research: Material needed: Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure. This records needed materials; no new research was executed. - Conditions for verification: Material for Resting conditions, equipment, repetitions, assessor and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Resting conditions, equipment, repetitions, assessor and timing with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N08 · Which arms do baseline and final values describe? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve wall sit 141.2→128.3 and no exercise 138.9→138.5 mmHg. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect. - Required materials and conditions: Original wall-sit/no-exercise values, units and baseline/final correspondence - Materials to obtain first: Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect. - Further research: Material needed: Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect. This records needed materials; no new research was executed. - Conditions for verification: Material for Original wall-sit/no-exercise values, units and baseline/final correspondence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original wall-sit/no-exercise values, units and baseline/final correspondence with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N09 · What do within-group changes and P values mean? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent records give within-wall-sit -12.9 mmHg/P<.001 and no-exercise -0.4 mmHg. The selected note also describes a within-group -12.9 change. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed. - Required materials and conditions: Within-group changes, tests, denominators and scope of estimation - Materials to obtain first: A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed. - Further research: Material needed: A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Within-group changes, tests, denominators and scope of estimation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Within-group changes, tests, denominators and scope of estimation with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N10 · Is the historical simple difference an adjusted effect? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent -12.5 mmHg is recorded as a simple difference between changes, not an adjusted estimate. It was not calculated in this conversion. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate. - Required materials and conditions: Original arithmetic wording versus adjusted between-group estimation - Materials to obtain first: Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate. - Further research: Material needed: Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate. This records needed materials; no new research was executed. - Conditions for verification: Material for Original arithmetic wording versus adjusted between-group estimation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Original arithmetic wording versus adjusted between-group estimation with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N11 · Are endpoint hierarchy and registration verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original leaves the exact prospective endpoint hierarchy unverified. Cohen’s evidence summary has no registration-identifier field. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable. - Required materials and conditions: SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes - Materials to obtain first: Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable. - Further research: Material needed: Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable. This records needed materials; no new research was executed. - Conditions for verification: Material for SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N12 · Are randomization and assessment roles verified? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Cohen is recorded as a multicenter 3-arm randomized trial. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed. - Required materials and conditions: Allocation, concealment, multicenter structure, blinding and assessment/analysis roles - Materials to obtain first: Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed. - Further research: Material needed: Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Allocation, concealment, multicenter structure, blinding and assessment/analysis roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Allocation, concealment, multicenter structure, blinding and assessment/analysis roles with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N13 · Are between-group analysis and missing-data handling verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve both complete follow-up and gaps in adjusted effects/CIs. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed. - Required materials and conditions: Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses - Materials to obtain first: ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed. - Further research: Material needed: ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N14 · How do SBP and DBP results differ? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Distinguish the key trial’s null between-group DBP result from its SBP signal. Diastolic pressure is a separate subclaim. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed. - Required materials and conditions: Values, denominators and prospective analysis for each pressure measure - Materials to obtain first: SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed. - Further research: Material needed: SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed. This records needed materials; no new research was executed. - Conditions for verification: Material for Values, denominators and prospective analysis for each pressure measure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Values, denominators and prospective analysis for each pressure measure with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N15 · What does the separate 4-week sham trial show? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Decaux has 30 participants over 4 weeks with wall sit, low-intensity sham and no exercise. Preserve SBP -15.2±9.2, DBP -4.6±5.0 mmHg and P<.05 versus controls. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation. - Required materials and conditions: Population, intensity, comparators, duration and each pressure outcome - Materials to obtain first: The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation. - Further research: Material needed: The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation. This records needed materials; no new research was executed. - Conditions for verification: Material for Population, intensity, comparators, duration and each pressure outcome must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Population, intensity, comparators, duration and each pressure outcome with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S02 ### N16 · Are registration identifiers distinct from prospective materials? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: NCT05025202 appears in Decaux’s citation. Neither evidence summary has a registration-identifier field. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence. - Required materials and conditions: Citation identifier, absent evidence-summary field and prospective plans - Materials to obtain first: Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence. - Further research: Material needed: Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence. This records needed materials; no new research was executed. - Conditions for verification: Material for Citation identifier, absent evidence-summary field and prospective plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Citation identifier, absent evidence-summary field and prospective plans with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S02 ### N17 · Are replication and report/sample relationships verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve original supportive directions across small trials and no strict upgrade to R2. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals. - Required materials and conditions: Duration, intervention, comparator, support, shared samples and related reports - Materials to obtain first: Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals. - Further research: Material needed: Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals. This records needed materials; no new research was executed. - Conditions for verification: Material for Duration, intervention, comparator, support, shared samples and related reports must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Duration, intervention, comparator, support, shared samples and related reports with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01, S02 ### N18 · Does resting pressure establish medication replacement or event prevention? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The original records that medication replacement and cardiovascular events were not tested. The original grade ? subclaim is separate. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions. - Required materials and conditions: Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries - Materials to obtain first: Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions. - Further research: Material needed: Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions. This records needed materials; no new research was executed. - Conditions for verification: Material for Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N19 · Are maintenance and long-term persistence verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Distinguish initial training 3 times weekly for 12 weeks from later maintenance 1 time weekly. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose. - Required materials and conditions: Initial, maintenance and long-term results, populations, denominators and comparisons - Materials to obtain first: Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose. - Further research: Material needed: Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose. This records needed materials; no new research was executed. - Conditions for verification: Material for Initial, maintenance and long-term results, populations, denominators and comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Initial, maintenance and long-term results, populations, denominators and comparisons with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N20 · Are actual delivery, coactivity and adherence verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Untreated adults, supervision, angle and intensity are original research conditions. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy. - Required materials and conditions: Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution - Materials to obtain first: Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy. - Further research: Material needed: Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy. This records needed materials; no new research was executed. - Conditions for verification: Material for Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N21 · What are Cohen’s public funding and COI declarations? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve Cohen’s Colombian Ministry of Science/Colciencias support and declaration of no COI. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification. - Required materials and conditions: Funding, product support, employed authors, analysis/publication roles and COI - Materials to obtain first: Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification. - Further research: Material needed: Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Funding, product support, employed authors, analysis/publication roles and COI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Funding, product support, employed authors, analysis/publication roles and COI with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N22 · Is Decaux’s funding verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Decaux’s original record states funding information was not provided. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: There is no material to fill this as no funding, independent support, no employed authors or no COI. - Required materials and conditions: Separate funding, support, employed-author and interest materials - Materials to obtain first: There is no material to fill this as no funding, independent support, no employed authors or no COI. - Further research: Material needed: There is no material to fill this as no funding, independent support, no employed authors or no COI. This records needed materials; no new research was executed. - Conditions for verification: Material for Separate funding, support, employed-author and interest materials must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Separate funding, support, employed-author and interest materials with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S02 ### N23 · Do 0 reported adverse events guarantee safety? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve all 77 key-trial participants completed and 0 reported adverse events. This is a limited supervised sample. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification. - Required materials and conditions: Harm definitions, collection, arm exposure/denominators, discontinuation and missingness - Materials to obtain first: Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification. - Further research: Material needed: Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification. This records needed materials; no new research was executed. - Conditions for verification: Material for Harm definitions, collection, arm exposure/denominators, discontinuation and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Harm definitions, collection, arm exposure/denominators, discontinuation and missingness with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01 ### N24 · Are acute and longer-term resting pressure the same? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Parent records mean 196/112 mmHg during a separate acute 90° hold. This is not the 12-week resting value. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report. - Required materials and conditions: Acute holds, resting results, bibliography, population and denominators - Materials to obtain first: That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report. - Further research: Material needed: That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report. This records needed materials; no new research was executed. - Conditions for verification: Material for Acute holds, resting results, bibliography, population and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Acute holds, resting results, bibliography, population and denominators with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01, S02 ### N25 · Are long-term and vulnerable-population harms verified? Verification status: Unverified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve parent caution and the acute/resting timing distinction. Give no new exercise, breathing, medication reduction/replacement or treatment instructions. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings. - Required materials and conditions: Supervision, exposure, vulnerable populations, concurrent factors and long-term harms - Materials to obtain first: Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings. - Further research: Material needed: Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings. This records needed materials; no new research was executed. - Conditions for verification: Material for Supervision, exposure, vulnerable populations, concurrent factors and long-term harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Supervision, exposure, vulnerable populations, concurrent factors and long-term harms with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01, S02 ### N26 · How are original verdicts, dates and corrections preserved? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: Preserve parent grade C with 54 points, both languages, axes, 2026-09-07, empty corrections and deliberation string, selected C/note and absent subclaim score/status/axes. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers. - Required materials and conditions: Parent/subclaim grades, scores, axes, both languages, dates and absent values - Materials to obtain first: Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers. - Further research: Material needed: Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers. This records needed materials; no new research was executed. - Conditions for verification: Material for Parent/subclaim grades, scores, axes, both languages, dates and absent values must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Parent/subclaim grades, scores, axes, both languages, dates and absent values with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01, S02 ### N27 · What material was actually read? Verification status: Partly verified Reading scope: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread - Current findings: The complete stored summary and bibliography were used. Distinguish reading the stored summary from unread external material. - Why unverified: The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification. - Reason for missing information: External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading. - Required materials and conditions: Report/material links and paper, registration, plan and support states - Materials to obtain first: External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading. - Further research: Material needed: External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading. This records needed materials; no new research was executed. - Conditions for verification: Material for Report/material links and paper, registration, plan and support states must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material. - Why this condition is needed: This condition connects Report/material links and paper, registration, plan and support states with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries. - Application exceptions: Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions. - Remaining uncertainty: External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification. - Referenced methods: Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced. - Related sources: S01, S02 ## Evidence and sources ### S01 Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621. [PubMed](https://pubmed.ncbi.nlm.nih.gov/36965163/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null Record level: Stored summary directly related to the selected question. Preserve 77 participants all completed, 12-week resting SBP 141.2→128.3 with wall sits versus 138.9→138.5 mmHg with no exercise, within-group -12.9/P<.001 versus -0.4. Historical simple -12.5 is not an adjusted effect. Arm denominators, variance, exact between-group 95% CIs and prospective hierarchy are unverified. Null between-group DBP, maintenance and 0 reported adverse events have separate contexts. Independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Funding, product-support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | ### S02 Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202. [PubMed](https://pubmed.ncbi.nlm.nih.gov/35083878/) Materials actually read: Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread Findings recorded in the summary: SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls Record level: Separate 30-participant, 4-week wall-sit/low-intensity sham/no-exercise report. Preserve SBP -15.2±9.2, DBP -4.6±5.0 mmHg and P<.05 versus controls. The meaning of ±, arm denominators, comparator-specific contrasts, effects/CIs and prospective hierarchy are unverified. This is not converted into the same 12-week effect or strict independent confirmation. Independent replication: Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report. | Material | Public availability | Access status | Actually read | Notes | |---|---|---|---|---| | Stored existing review summary | Preserved copy of the complete parent-verdict stored summary | Stored summary | Summary read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | External paper | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Registration material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Protocol | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Statistical analysis plan | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | | Funding, product-support and COI material | Original bibliographic link or needed material; external public availability/access status unverified | Unread; access not attempted | Not read | Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred. | ## Review criteria and methods These are Chamgap's own application conditions, informed by the relevant sections of official methodological guidance. They do not constitute official assessment-tool certification or a new efficacy score. - M03 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03) · §3.1, §3.2.1–3.2.3, MECIR C5/C7/C13 · Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M04 [Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04) · §4.5, §4.6.1–4.6.3, MECIR C42 · Distinguish studies from reports and link them; do not omit a study solely because results are unreported. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M08 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08) · §8.1–8.2.3, Table 8.2.a · Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M15 [Cochrane Handbook 6.5 (2024), chapter updated 2023-08](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15) · §15.2.4, §15.3.1–15.3.3 · Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. - M19 [Cochrane Handbook 6.5 (2024), chapter updated 2019-10](https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19) · §19.1.2, §19.2.1–19.2.4 · Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates. · Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed. ## What the statuses mean - Met: A state used when required evidence is confirmed after user review. This production does not declare that review complete. - Partly verified: Some information in the stored summary is linked into the table. External comparison/content review is not complete. - Unverified: The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety. - Review incomplete: User review pending. - Not reported: Not reported within the stored material actually read; not extended to the entire primary paper. - Inaccessible: Means an actual access failure. Access not attempted here is not assigned this state. - Not applicable: Not used as a substitute for an evidence gap. - Conflicting data: Requires an observed disagreement under the same comparison criteria; not automatically judged in this production. - Insufficient evidence for the conditions: Marks a gap in additional material required by the selected conditions; not a new efficacy grade. ## Change history 2026-10-16 · Public page/materials 1.0. Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed.