{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v3000-s0", "verdict_number": "3000", "title": "Supervised wall sits × lower resting SBP at 12 weeks", "view_version": "1.0", "view_created_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "Cohen records 77 untreated adults aged 35–65 with hypertension, all completed. Arm denominators, diagnosis/baseline severity, eligibility/exclusions and measurement completeness are unverified. Decaux has a separate 30 participants; counts are not added.", "intervention": "Knee angle, intensity calibration and supervision belong to the original supervised isometric wall-sit conditions. Exact settings, actual delivery and adherence are unverified. This sheet describes research records and creates no personal exercise, breathing or treatment instructions.", "dose": "Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly. Maintenance allocation, denominators and exact results are unverified. 1 time weekly is not treated as an adequate starting dose.", "comparator": "Within Cohen’s 3 handgrip, wall-sit and no-exercise arms, the selected comparison is wall sit versus no exercise. Decaux’s 4-week wall-sit, low-intensity sham and no-exercise comparisons are separate. Arm denominators, contact, expectations, activity and exact comparator-specific contrasts are unverified.", "endpoint": "At 12 weeks, office resting SBP is 141.2→128.3 with wall sits versus 138.9→138.5 mmHg with no exercise. Distinguish original within-group changes -12.9/P<.001 and -0.4 from the historical simple difference -12.5. That simple difference is not an adjusted estimate; exact between-group 95% CIs, model and prospective hierarchy are unverified. The null between-group DBP result is separate.", "duration": "Initial 12 weeks and later maintenance, Decaux 4 weeks, and mean 196/112 mmHg during a separate acute 90° hold refer to different times. The acute study bibliography, population and denominators are not linked. Do not extend this to long-term effects, treated people, other ages, medication replacement or cardiovascular events.", "excluded_extensions": [ "Transferring within-group changes/P or a historical simple difference into adjusted between-group effects/CIs", "Transferring later once-weekly maintenance into a minimum starting dose", "Combining resting SBP, DBP and acute in-exercise pressure as one result", "Extending a blood-pressure surrogate to medication equivalence, dose reduction/replacement or cardiovascular-event prevention", "Adding arms, outcomes, maintenance phases, related reports or sheets into new unique-trial/participant or independent-replication totals", "Using original grades, public funding, COI declarations or 0 reported adverse events as new verdicts or independence/safety certification", "Creating new numbers, effects, CIs, grades or exercise, breathing, medication reduction/replacement or treatment instructions" ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "What is the selected 12-week resting-SBP question?", "needed": "Exact subclaim, grade/note and parent verdict", "role": "Required", "role_reason": "This condition connects Exact subclaim, grade/note and parent verdict with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Exact subclaim, grade/note and parent verdict must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The subclaim has no score, status or axis fields. Do not fill them with parent values. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The selection is lower resting SBP after 12 weeks of supervised wall sits. Preserve subclaim C and the within-group -12.9 mmHg note. Parent grade C with 54 points is separate context.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The subclaim has no score, status or axis fields. Do not fill them with parent values.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The subclaim has no score, status or axis fields. Do not fill them with parent values." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Which adults with hypertension participated?", "needed": "Diagnosis, age, medication status, baseline risk and eligibility", "role": "Required", "role_reason": "This condition connects Diagnosis, age, medication status, baseline risk and eligibility with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Diagnosis, age, medication status, baseline risk and eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Cohen records 77 untreated adults aged 35–65 with hypertension.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact diagnosis, baseline severity, eligibility/exclusions, sex, comorbidities and recruitment details are needed. Do not extend to treated people or other ages." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "What was the supervised wall-sit intervention?", "needed": "Supervision, knee angle, intensity calibration, actual delivery and components", "role": "Required", "role_reason": "This condition connects Supervision, knee angle, intensity calibration, actual delivery and components with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Supervision, knee angle, intensity calibration, actual delivery and components must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The original text records angle, intensity and supervision as parts of supervised isometric wall sits.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Individual settings, supervision, actual delivery and adherence are needed. Research conditions are not new exercise instructions." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "How do initial training and maintenance differ?", "needed": "Separate attribution of initial/maintenance schedules and analyses", "role": "Required", "role_reason": "This condition connects Separate attribution of initial/maintenance schedules and analyses with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Separate attribution of initial/maintenance schedules and analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish original initial training 3 times weekly for 12 weeks, 4 holds of 2 minutes with 2-minute seated rests, and later maintenance 1 time weekly.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Maintenance allocation, duration, denominators and detailed results are needed. Do not transfer maintenance into a minimum starting dose." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What were the actual comparators?", "needed": "Wall sit versus no exercise and the scope of the other exercise arm", "role": "Required", "role_reason": "This condition connects Wall sit versus no exercise and the scope of the other exercise arm with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Wall sit versus no exercise and the scope of the other exercise arm must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "77 participants were assigned to 3 handgrip, wall-sit and no-exercise arms. Selected values describe wall sit versus no exercise.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm allocation, denominators, contact, expectations and usual activity are needed. Do not combine handgrip with the wall-sit intervention." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Does complete follow-up establish endpoint denominators?", "needed": "Overall allocation/completion versus arm denominators, missing measurements and analysis rules", "role": "Required", "role_reason": "This condition connects Overall allocation/completion versus arm denominators, missing measurements and analysis rules with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Overall allocation/completion versus arm denominators, missing measurements and analysis rules must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve the original record that all 77 Cohen participants completed.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Wall-sit, no-exercise and handgrip denominators, valid/missing measurements and analysis rules are needed. Completion does not establish complete measurement of every outcome." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "How was resting office SBP measured?", "needed": "Resting conditions, equipment, repetitions, assessor and timing", "role": "Required", "role_reason": "This condition connects Resting conditions, equipment, repetitions, assessor and timing with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Resting conditions, equipment, repetitions, assessor and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The endpoint is recorded as 12-week office resting blood pressure.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Equipment, rest, repetitions, assessor blinding, standardization and medication/activity/time conditions are needed. Do not combine with in-exercise pressure." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Which arms do baseline and final values describe?", "needed": "Original wall-sit/no-exercise values, units and baseline/final correspondence", "role": "Required", "role_reason": "This condition connects Original wall-sit/no-exercise values, units and baseline/final correspondence with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Original wall-sit/no-exercise values, units and baseline/final correspondence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve wall sit 141.2→128.3 and no exercise 138.9→138.5 mmHg.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm denominators, variance, distributions, models and CIs are needed. Calculate no new difference, change or effect." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "What do within-group changes and P values mean?", "needed": "Within-group changes, tests, denominators and scope of estimation", "role": "Required", "role_reason": "This condition connects Within-group changes, tests, denominators and scope of estimation with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Within-group changes, tests, denominators and scope of estimation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent records give within-wall-sit -12.9 mmHg/P<.001 and no-exercise -0.4 mmHg. The selected note also describes a within-group -12.9 change.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "A within-group P value is not a between-group P value. Within-group CIs, variance, denominators and between-group tests are needed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Is the historical simple difference an adjusted effect?", "needed": "Original arithmetic wording versus adjusted between-group estimation", "role": "Required", "role_reason": "This condition connects Original arithmetic wording versus adjusted between-group estimation with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Original arithmetic wording versus adjusted between-group estimation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent -12.5 mmHg is recorded as a simple difference between changes, not an adjusted estimate. It was not calculated in this conversion.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Adjusted effects, models, exact between-group 95% CIs and P values are needed. Do not promote a historical value into a new estimate." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Are endpoint hierarchy and registration verified?", "needed": "SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes", "role": "Required", "role_reason": "This condition connects SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for SBP/DBP, initial/maintenance, prospective 1st/2nd outcomes and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The original leaves the exact prospective endpoint hierarchy unverified. Cohen’s evidence summary has no registration-identifier field.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration, protocols, SAPs, multiplicity and change history are unread. Do not fill an absent field as unregistered or not applicable." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Are randomization and assessment roles verified?", "needed": "Allocation, concealment, multicenter structure, blinding and assessment/analysis roles", "role": "Required", "role_reason": "This condition connects Allocation, concealment, multicenter structure, blinding and assessment/analysis roles with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Allocation, concealment, multicenter structure, blinding and assessment/analysis roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Cohen is recorded as a multicenter 3-arm randomized trial.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Allocation concealment, center structure, participant/assessor/analyst blinding and expectations are needed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Are between-group analysis and missing-data handling verified?", "needed": "Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses", "role": "Required", "role_reason": "This condition connects Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Estimand, baseline adjustment, ITT/PP, repeated/missing data and sensitivity analyses must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve both complete follow-up and gaps in adjusted effects/CIs.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "ITT/PP, valid/excluded measurements, center/repeated-measure models, covariates, missing data and sensitivity analyses are needed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "How do SBP and DBP results differ?", "needed": "Values, denominators and prospective analysis for each pressure measure", "role": "Required", "role_reason": "This condition connects Values, denominators and prospective analysis for each pressure measure with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Values, denominators and prospective analysis for each pressure measure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish the key trial’s null between-group DBP result from its SBP signal. Diastolic pressure is a separate subclaim.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "SBP does not substitute for DBP effects. Exact original DBP values, CIs and analyses are needed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "What does the separate 4-week sham trial show?", "needed": "Population, intensity, comparators, duration and each pressure outcome", "role": "Required", "role_reason": "This condition connects Population, intensity, comparators, duration and each pressure outcome with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Population, intensity, comparators, duration and each pressure outcome must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Decaux has 30 participants over 4 weeks with wall sit, low-intensity sham and no exercise. Preserve SBP -15.2±9.2, DBP -4.6±5.0 mmHg and P<.05 versus controls.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "The variance type for ±, arm denominators, original changes/models, comparator-specific contrasts and CIs are needed. Do not turn this into the same 12-week effect or independent confirmation." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are registration identifiers distinct from prospective materials?", "needed": "Citation identifier, absent evidence-summary field and prospective plans", "role": "Required", "role_reason": "This condition connects Citation identifier, absent evidence-summary field and prospective plans with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Citation identifier, absent evidence-summary field and prospective plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "NCT05025202 appears in Decaux’s citation. Neither evidence summary has a registration-identifier field.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Registration timing, changes, prospective endpoints, protocols and SAPs are unread. An identifier alone does not certify prospective status or independence." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are replication and report/sample relationships verified?", "needed": "Duration, intervention, comparator, support, shared samples and related reports", "role": "Required", "role_reason": "This condition connects Duration, intervention, comparator, support, shared samples and related reports with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Duration, intervention, comparator, support, shared samples and related reports must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original supportive directions across small trials and no strict upgrade to R2.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Independent confirmation under the same conditions and unique-trial/participant or replication totals remain unverified. Reports, times, arms and sheets are not new clinical totals." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Does resting pressure establish medication replacement or event prevention?", "needed": "Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries", "role": "Required", "role_reason": "This condition connects Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Surrogate, medication comparison, treatment replacement and cardiovascular-event boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The original records that medication replacement and cardiovascular events were not tested. The original grade ? subclaim is separate.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Do not transfer SBP into medication equivalence, dose reduction/replacement, heart-attack prevention or long-term clinical effects. Create no treatment instructions." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Are maintenance and long-term persistence verified?", "needed": "Initial, maintenance and long-term results, populations, denominators and comparisons", "role": "Required", "role_reason": "This condition connects Initial, maintenance and long-term results, populations, denominators and comparisons with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Initial, maintenance and long-term results, populations, denominators and comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Distinguish initial training 3 times weekly for 12 weeks from later maintenance 1 time weekly.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Exact maintenance/long-term effects, denominators, comparisons and data for other ages or treated people are needed. Propose no new minimum exercise dose." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are actual delivery, coactivity and adherence verified?", "needed": "Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution", "role": "Supplementary", "role_reason": "This condition connects Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Concurrent exercise, medication/lifestyle changes, supervision, delivery and data attribution must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Untreated adults, supervision, angle and intensity are original research conditions.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Arm-specific coactivity/changes, actual training, supervision and adherence are needed. Give no personal exercise or medication policy." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What are Cohen’s public funding and COI declarations?", "needed": "Funding, product support, employed authors, analysis/publication roles and COI", "role": "Required", "role_reason": "This condition connects Funding, product support, employed authors, analysis/publication roles and COI with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Funding, product support, employed authors, analysis/publication roles and COI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Cohen’s Colombian Ministry of Science/Colciencias support and declaration of no COI.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original support/product, employed-author, analysis/publication-control and declaration materials are unread. Parent independent-funding wording is not new certification." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Is Decaux’s funding verified?", "needed": "Separate funding, support, employed-author and interest materials", "role": "Required", "role_reason": "This condition connects Separate funding, support, employed-author and interest materials with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Separate funding, support, employed-author and interest materials must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: There is no material to fill this as no funding, independent support, no employed authors or no COI. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Decaux’s original record states funding information was not provided.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "There is no material to fill this as no funding, independent support, no employed authors or no COI.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "There is no material to fill this as no funding, independent support, no employed authors or no COI." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Do 0 reported adverse events guarantee safety?", "needed": "Harm definitions, collection, arm exposure/denominators, discontinuation and missingness", "role": "Supplementary", "role_reason": "This condition connects Harm definitions, collection, arm exposure/denominators, discontinuation and missingness with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Harm definitions, collection, arm exposure/denominators, discontinuation and missingness must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve all 77 key-trial participants completed and 0 reported adverse events. This is a limited supervised sample.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Collection, arm exposure/denominators, severity, missingness, discontinuation and long-term harms are needed. Do not turn 0 into new safety certification." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Are acute and longer-term resting pressure the same?", "needed": "Acute holds, resting results, bibliography, population and denominators", "role": "Supplementary", "role_reason": "This condition connects Acute holds, resting results, bibliography, population and denominators with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Acute holds, resting results, bibliography, population and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Parent records mean 196/112 mmHg during a separate acute 90° hold. This is not the 12-week resting value.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "That acute study’s bibliography, population, denominators and measurement/exposure details are not linked. Do not borrow the other trials’ denominators or create a hypothetical report." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "Are long-term and vulnerable-population harms verified?", "needed": "Supervision, exposure, vulnerable populations, concurrent factors and long-term harms", "role": "Supplementary", "role_reason": "This condition connects Supervision, exposure, vulnerable populations, concurrent factors and long-term harms with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Supervision, exposure, vulnerable populations, concurrent factors and long-term harms must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent caution and the acute/resting timing distinction. Give no new exercise, breathing, medication reduction/replacement or treatment instructions.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Population/exposure-specific long-term harms, alternative causes and discontinuation materials are needed. Do not extend a small supervised sample into safety certification for other populations or unsupervised settings." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "How are original verdicts, dates and corrections preserved?", "needed": "Parent/subclaim grades, scores, axes, both languages, dates and absent values", "role": "Required", "role_reason": "This condition connects Parent/subclaim grades, scores, axes, both languages, dates and absent values with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Parent/subclaim grades, scores, axes, both languages, dates and absent values must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent grade C with 54 points, both languages, axes, 2026-09-07, empty corrections and deliberation string, selected C/note and absent subclaim score/status/axes.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Historical key/sham, funding and acute-verification wording is not current review or clinical certification. Create no new grades, effects or hypothetical numbers." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "What material was actually read?", "needed": "Report/material links and paper, registration, plan and support states", "role": "Required", "role_reason": "This condition connects Report/material links and paper, registration, plan and support states with selected 12-week resting systolic pressure, within- versus between-group comparisons, initial training versus maintenance, and measurement, denominator, support and harm boundaries.", "application_exception": "Preserve selected subclaim C and its within-group -12.9 mmHg note. Distinguish absent subclaim score/status/axes from parent grade C with 54 points. Within-group changes or a historical simple difference are not adjusted between-group effects; maintenance is not a minimum starting dose. Create no new numbers, CIs, totals, grades, independence/safety certification or exercise, breathing, medication or treatment instructions.", "criterion": "Material for Report/material links and paper, registration, plan and support states must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The complete stored summary and bibliography were used. Distinguish reading the stored summary from unread external material.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "External papers, registration, protocols, SAPs, support and acute originals are unread; access was not attempted. Links or historical verification do not establish current reading." } ], "reports": [ { "report_id": "S01", "title": "Cohen DD, Aroca-Martinez G, Carreño-Robayo J, et al. Reductions in systolic blood pressure achieved by hypertensives with three isometric training sessions per week are maintained with a single session per week. J Clin Hypertens. 2023;25(4):380-387. PMID: 36965163. PMCID: PMC10085809. DOI: 10.1111/jch.14621.", "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/", "report_type": "Multicenter three-arm randomized trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S01; unique counts and independent replication unverified", "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.", "observed_result": "SBP 141.2 to 128.3 vs 138.9 to 138.5 mmHg; DBP between-group null", "result_level": "Stored summary directly related to the selected question. Preserve 77 participants all completed, 12-week resting SBP 141.2→128.3 with wall sits versus 138.9→138.5 mmHg with no exercise, within-group -12.9/P<.001 versus -0.4. Historical simple -12.5 is not an adjusted effect. Arm denominators, variance, exact between-group 95% CIs and prospective hierarchy are unverified. Null between-group DBP, maintenance and 0 reported adverse events have separate contexts.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 36965163, DOI 10.1111/jch.14621, PMCID PMC10085809 and bibliography. The evidence summary has no registration-identifier field. No registration identifier is recorded in the citation either. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/36965163/" } ] }, { "report_id": "S02", "title": "Decaux A et al. Blood pressure and cardiac autonomic adaptations to isometric exercise training: A randomized sham-controlled study. Physiol Rep. 2022;10(2):e15112. PMID: 35083878. PMCID: PMC8792514. DOI: 10.14814/phy2.15112. NCT05025202.", "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/", "report_type": "Randomized wall-sit, low-intensity sham, and no-exercise trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S02; unique counts and independent replication unverified", "independent_replication": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report.", "observed_result": "SBP -15.2±9.2 and DBP -4.6±5.0 mmHg; P<.05 vs controls", "result_level": "Separate 30-participant, 4-week wall-sit/low-intensity sham/no-exercise report. Preserve SBP -15.2±9.2, DBP -4.6±5.0 mmHg and P<.05 versus controls. The meaning of ±, arm denominators, comparator-specific contrasts, effects/CIs and prospective hierarchy are unverified. This is not converted into the same 12-week effect or strict independent confirmation.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 35083878, DOI 10.14814/phy2.15112, PMCID PMC8792514 and bibliography. The evidence summary has no registration-identifier field. NCT05025202 is recorded only in the citation. An absent field does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35083878/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.", "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.", "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.", "Review incomplete": "User review pending.", "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.", "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.", "Not applicable": "Not used as a substitute for an evidence gap.", "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.", "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Cohen and Decaux have separate preserved bibliographies; the parent and 3 subclaim questions share the same reports. Intervention, comparator, duration and support are not certified identical across the 12-week no-exercise and 4-week sham comparisons. Arms, repeated measures, maintenance, reports and sheets are not counted as new unique-trial/participant or independent-replication totals. An unidentified acute safety description does not create a hypothetical report." }, "history": [ { "date": "2026-10-16", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public pages and materials were prepared from the existing 27 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-16" }