{ "schema_version": "chamgap-public-evidence-check-1.0", "public_id": "v2999-s1", "verdict_number": "2999", "title": "Repeated cold immersion × muscle loss or universal strength impairment", "view_version": "1.0", "view_created_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "review_date": null, "legacy_evidence_date": "2026-09-07", "review_scope": { "materials_read": "Existing review summaries and stored records of methodological application", "clinical_papers_directly_read": false, "new_clinical_search": false, "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.", "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature." }, "claim_context": { "population": "S01 Roberts concerns resistance-trained young men, with 24 assigned/21 completed. S02 Fyfe is a separate trial of 16 participants; detailed eligibility and arm-/measurement-specific denominators are unverified. Age, training history, disease/sex range, baseline nutrition and exclusions are not invented and the two sample sizes are not summed.", "intervention": "The selected claim concerns muscle loss or impairment of every strength adaptation with repeated cold immersion. Original research concerns repeated immersion after resistance training versus recovery controls. Distinguish Roberts lower-body/active recovery from Fyfe whole-body bibliography/passive rest; immersion extent, load, actual exposure and nutrition/adherence are unverified. No new instructions are created.", "dose": "Roberts original specification is 10°C for 10 minutes within 10 minutes after training, repeated 2 times weekly. The separate Fyfe trial uses 10°C for 15 minutes versus indoor rest at 23°C. Actual temperatures, adherence and interruptions are unverified; no new total exposure, optimal temperature/timing or implementation method is calculated or recommended.", "comparator": "Roberts compared cold immersion with 10 minutes of low-intensity cycling as active recovery; Fyfe used passive indoor rest at 23°C. Active and passive controls are not combined as the same comparison. Contact, nutrition products/diet, training load, actual exposure and their matching or separate contributions are unverified.", "endpoint": "Read the selected muscle-loss/universal-strength claim against Roberts gains in both groups, 309±73 g versus 103±71 g, original difference -206 g/d=-4.1/P<.001, and Fyfe less type II hypertrophy with unclear maximum-strength difference. The meaning of ±, arm-/measure-specific denominators, exact strength values/CIs and prospective hierarchy are unverified. Less gain is not baseline loss or uniform strength impairment.", "duration": "Roberts 12-week MRI and Fyfe 7-week fiber/strength are separate results. Acute recovery and verdict 1247 concern other times/questions. Direct material for post-training persistence, different exposures, every sport, varied populations or medical harms is unverified.", "excluded_extensions": [ "Transferring a gain difference of -206 g into muscle loss from baseline or impairment of every strength adaptation", "Combining MRI grams, type II fiber area, maximum strength and acute signaling as the same endpoint/effect", "Treating active/passive controls, training/exposure, duration and nutrition as identical conditions", "Summing assigned/completer counts, multiple outcomes, acute/longer-term populations, related reports or both sheets into new participant/unique-trial totals", "Inheriting original parent grade D with 28 points, E-, historical verification or independence wording as absent subclaim values or new verdicts/certification", "Treating adverse adaptation for a training goal or unrelated-injury withdrawal as confirmed cold-induced medical harm", "Creating new effects, CIs, attrition counts/rates, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions" ] }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "How does the selected muscle-loss/universal-strength claim differ from the parent verdict?", "needed": "Selected subclaim and parent gain context", "role": "Required", "role_reason": "This condition connects Selected subclaim and parent gain context with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Selected subclaim and parent gain context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Selected subclaim records, original note and claim boundaries. Parent scores/axes do not fill absent subclaim values. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The selected claim concerns muscle loss or impairment of every strength adaptation. Preserve subclaim D and the note of muscle gains in both groups and differing maximum-strength results. Parent grade D with 28 points/E- concerns attenuated gains.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Selected subclaim records, original note and claim boundaries. Parent scores/axes do not fill absent subclaim values.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Selected subclaim records, original note and claim boundaries. Parent scores/axes do not fill absent subclaim values." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "How do attenuated gains differ from actual muscle loss?", "needed": "Original MRI gains and baseline comparisons", "role": "Required", "role_reason": "This condition connects Original MRI gains and baseline comparisons with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original MRI gains and baseline comparisons must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original MRI tables, baseline/end values, gain definitions and analysis denominators. The meaning of ± and exact effects/CIs are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Roberts MRI gains are active recovery 309±73 g and CWI 103±71 g; both groups gained muscle. These preserved results are not converted into muscle loss from baseline.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original MRI tables, baseline/end values, gain definitions and analysis denominators. The meaning of ± and exact effects/CIs are unverified.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original MRI tables, baseline/end values, gain definitions and analysis denominators. The meaning of ± and exact effects/CIs are unverified." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Are universal-strength and maximum-strength results distinguished?", "needed": "Hypertrophy, maximum strength and other strength measures", "role": "Required", "role_reason": "This condition connects Hypertrophy, maximum strength and other strength measures with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Hypertrophy, maximum strength and other strength measures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Trial-specific strength measures, original tables, prospective analyses, effects/CIs and denominators. Fiber results do not establish impairment of every strength outcome. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Fyfe records both less type II hypertrophy and no clear maximum-strength difference. The parent states that strength findings differed across trials.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Trial-specific strength measures, original tables, prospective analyses, effects/CIs and denominators. Fiber results do not establish impairment of every strength outcome.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific strength measures, original tables, prospective analyses, effects/CIs and denominators. Fiber results do not establish impairment of every strength outcome." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "Are trained young men and the separate trial the same population?", "needed": "Report-specific populations and original denominators", "role": "Required", "role_reason": "This condition connects Report-specific populations and original denominators with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Report-specific populations and original denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Trial-specific eligibility, baseline tables and arm flow. Counts are not summed and representative populations are not automatically assigned. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The main Roberts trial concerns resistance-trained young men with 24 assigned/21 completed. Separate Fyfe records 16 participants over 7 weeks; exact eligibility and arm-/measure-specific denominators are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Trial-specific eligibility, baseline tables and arm flow. Counts are not summed and representative populations are not automatically assigned.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific eligibility, baseline tables and arm flow. Counts are not summed and representative populations are not automatically assigned." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "What were the original repeated post-exercise cold specifications?", "needed": "Cold/training research records", "role": "Required", "role_reason": "This condition connects Cold/training research records with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Cold/training research records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Intervention/training manuals, delivery and adherence material. Research specifications are not new cold-water, exercise or treatment instructions. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Roberts 10°C for 10 minutes within 10 minutes after training, 2 times weekly for 12 weeks, and separate Fyfe 10°C for 15 minutes over 7 weeks are original research records. Actual delivery, immersion extent and training details are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Intervention/training manuals, delivery and adherence material. Research specifications are not new cold-water, exercise or treatment instructions.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Intervention/training manuals, delivery and adherence material. Research specifications are not new cold-water, exercise or treatment instructions." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "Are active cycling and passive-rest controls distinguished?", "needed": "Report-specific recovery controls and shared management", "role": "Required", "role_reason": "This condition connects Report-specific recovery controls and shared management with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Report-specific recovery controls and shared management must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Control, training/recovery, contact, exposure and nutrition material. Separate active-recovery contributions and matching of management are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Roberts control is 10 minutes of low-intensity cycling as active recovery; Fyfe uses passive indoor rest at 23°C. Different controls are not combined as the same comparative effect.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Control, training/recovery, contact, exposure and nutrition material. Separate active-recovery contributions and matching of management are unverified.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Control, training/recovery, contact, exposure and nutrition material. Separate active-recovery contributions and matching of management are unverified." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What denominators do 24 assigned/21 completed represent?", "needed": "Complete-case analysis and outcome denominators", "role": "Required", "role_reason": "This condition connects Complete-case analysis and outcome denominators with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Complete-case analysis and outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Flow, arm denominators and missing/excluded-data material. Completer counts do not replace every endpoint denominator and no new attrition count/rate is calculated. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve the original Roberts record of 24 assigned/21 completed and complete-case analysis. Arm-/measurement-specific analysis denominators, exclusions and missingness are separately unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Flow, arm denominators and missing/excluded-data material. Completer counts do not replace every endpoint denominator and no new attrition count/rate is calculated.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Flow, arm denominators and missing/excluded-data material. Completer counts do not replace every endpoint denominator and no new attrition count/rate is calculated." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "Are MRI gains and fiber area the same measurement?", "needed": "Distinguishing measurement type, derivation and region", "role": "Required", "role_reason": "This condition connects Distinguishing measurement type, derivation and region with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Distinguishing measurement type, derivation and region must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: MRI/fiber measurement, quality, original material and denominators. Fiber area is not converted into MRI grams. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Roberts concerns MRI quadriceps gains; Fyfe concerns fiber area and strength. Different measurement labels/results are not combined as the same effect or denominator.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "MRI/fiber measurement, quality, original material and denominators. Fiber area is not converted into MRI grams.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "MRI/fiber measurement, quality, original material and denominators. Fiber area is not converted into MRI grams." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "What original record contains -206 g, d=-4.1 and P?", "needed": "Historical original estimates and signs", "role": "Required", "role_reason": "This condition connects Historical original estimates and signs with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Historical original estimates and signs must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original estimates, effect scales/variance, analysis outputs and arm denominators. The definition of d, meaning of ±, intervals and adjustment are unverified. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent explanation -206 g, d=-4.1, P<.001 and the evidence-summary gain difference as original values. No new difference, effect or CI is calculated and these values are not baseline muscle loss.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original estimates, effect scales/variance, analysis outputs and arm denominators. The definition of d, meaning of ±, intervals and adjustment are unverified.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original estimates, effect scales/variance, analysis outputs and arm denominators. The definition of d, meaning of ±, intervals and adjustment are unverified." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "Were Fyfe hypertrophy and strength findings both retained?", "needed": "Measure-specific findings and scope boundaries", "role": "Required", "role_reason": "This condition connects Measure-specific findings and scope boundaries with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Measure-specific findings and scope boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: All Fyfe outcome tables, SAP, exact effects/CIs and denominators. Null results do not establish 0 effect or equivalence. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve both less type II hypertrophy and no clear maximum-strength attenuation. Directional hypertrophy support is not substituted for the same result across every strength outcome.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "All Fyfe outcome tables, SAP, exact effects/CIs and denominators. Null results do not establish 0 effect or equivalence.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "All Fyfe outcome tables, SAP, exact effects/CIs and denominators. Null results do not establish 0 effect or equivalence." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Were completer, assigned, actual-use analyses and baseline adjustment verified?", "needed": "Analysis populations, models, missingness and prospective plans", "role": "Required", "role_reason": "This condition connects Analysis populations, models, missingness and prospective plans with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Analysis populations, models, missingness and prospective plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: SAPs, missingness/denominators, models and sensitivity results. No new analysis, adjustment or effect estimate is executed. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve main-trial complete-case analysis and unverified prospective hierarchy/CIs. Full-assignment/actual-use analyses, baseline adjustment, missingness/sensitivity and actual models are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "SAPs, missingness/denominators, models and sensitivity results. No new analysis, adjustment or effect estimate is executed.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "SAPs, missingness/denominators, models and sensitivity results. No new analysis, adjustment or effect estimate is executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "Are allocation, concealment, assessor/analyst blinding known?", "needed": "Design labels and actual bias conditions", "role": "Required", "role_reason": "This condition connects Design names and actual bias conditions with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Design labels and actual bias conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Trial-specific allocation, assessor roles and protocols. Design names alone do not establish blinding, official bias assessment or passing review. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Original evidence records 12-week active-control and 7-week passive-control training trials. Actual allocation, concealment and assessor/analyst allocation-awareness procedures are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Trial-specific allocation, assessor roles and protocols. Design names alone do not establish blinding, official bias assessment or passing review.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Trial-specific allocation, assessor roles and protocols. Design names alone do not establish blinding, official bias assessment or passing review." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "How do absent registration fields differ from prospective hierarchy?", "needed": "Original registration identity, plans and changes", "role": "Required", "role_reason": "This condition connects Original registration identity, plans and changes with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original registration identity, plans and changes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original registration/change history, protocols and SAPs. No new identifier, registry address or successful reading is inferred. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Both original evidence summaries lack registration-identifier fields. The parent explicitly notes unverified prospective primary hierarchy. Field absence does not establish no registration or prospective verification.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original registration/change history, protocols and SAPs. No new identifier, registry address or successful reading is inferred.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original registration/change history, protocols and SAPs. No new identifier, registry address or successful reading is inferred." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "Are shared training, nutrition and cold-exposure contributions separated?", "needed": "Training, products, intake, adherence and shared management", "role": "Supplementary", "role_reason": "This condition connects Training, products, intake, adherence and shared management with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Training, products, intake, adherence and shared management must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Training, nutrition, adherence and support-distribution material. In-kind provision does not establish matched intake or an isolated cold effect. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The main comparison concerns gains during the same training and includes Body Science in-kind nutrition-product support. Training, nutrition, arm product distribution and actual exposure/adherence details are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Training, nutrition, adherence and support-distribution material. In-kind provision does not establish matched intake or an isolated cold effect.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Training, nutrition, adherence and support-distribution material. In-kind provision does not establish matched intake or an isolated cold effect." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Can 12-/7-week findings extend to longer periods or every sport?", "needed": "Directness by duration, population and measure", "role": "Required", "role_reason": "This condition connects Directness by duration, population and measure with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Directness by duration, population and measure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct duration-, population- and measure-specific material. No uniform impairment or sustained effect beyond original durations/conditions is created. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve separate 12-week MRI and 7-week fiber/strength results. Direct material for post-training persistence, different exposures, every sport and population is unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct duration-, population- and measure-specific material. No uniform impairment or sustained effect beyond original durations/conditions is created.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct duration-, population- and measure-specific material. No uniform impairment or sustained effect beyond original durations/conditions is created." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are acute recovery, longer-term adaptation and the other verdict distinct?", "needed": "Outcome goals, times and questions", "role": "Required", "role_reason": "This condition connects Outcome goals, times and questions with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Outcome goals, times and questions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Direct material for the selected longer-term question and outcome/time/cohort linkage. Acute recovery is not transferred into longer-term adaptation or replication of another verdict. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The original separates acute recovery from longer-term adaptation and describes verdict 1247 as an acute soreness/recovery question. Its original material was not newly read in this work.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Direct material for the selected longer-term question and outcome/time/cohort linkage. Acute recovery is not transferred into longer-term adaptation or replication of another verdict.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Direct material for the selected longer-term question and outcome/time/cohort linkage. Acute recovery is not transferred into longer-term adaptation or replication of another verdict." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Are adverse training adaptation and medical harm the same?", "needed": "Verdict direction and actual medical events", "role": "Supplementary", "role_reason": "This condition connects Verdict direction and actual medical events with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Verdict direction and actual medical events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Separate adaptation and medical-harm material. Original direction/grade does not certify new harm rates or safety. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve original wording that parent E-/grade D with 28 points denotes adverse adaptation and does not mean a null result. Disadvantage for a training goal is distinct from actual medical-harm occurrence/frequency.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Separate adaptation and medical-harm material. Original direction/grade does not certify new harm rates or safety.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Separate adaptation and medical-harm material. Original direction/grade does not certify new harm rates or safety." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Was independence across reports, populations and sheets verified?", "needed": "Linkage of reports, cohorts and multiple outcomes", "role": "Required", "role_reason": "This condition connects Linkage of reports, cohorts and multiple outcomes with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Linkage of reports, cohorts and multiple outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific cohorts, support, protocols and outcome lists. The same populations, sheets or measures are not summed as new participants or independent replications. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The parent and both subclaim sheets share the same two longer-term reports, preserving gains in both groups and maximum-strength disagreement. Multiple outcomes, acute/longer-term population relationships, related-report overlap and unique totals are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Report-specific cohorts, support, protocols and outcome lists. The same populations, sheets or measures are not summed as new participants or independent replications.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific cohorts, support, protocols and outcome lists. The same populations, sheets or measures are not summed as new participants or independent replications." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "What public/university and in-kind support did Roberts record?", "needed": "Funding, product support, affiliations and roles", "role": "Required", "role_reason": "This condition connects Funding, product support, affiliations and roles with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Funding, product support, affiliations and roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original support, affiliations, interests, products and roles. No new absence of company-employed authors or analysis/reporting involvement is established. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve public/university support together with Body Science in-kind nutrition products. Actual products, distribution, affiliations, interests and analysis/publication involvement are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original support, affiliations, interests, products and roles. No new absence of company-employed authors or analysis/reporting involvement is established.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original support, affiliations, interests, products and roles. No new absence of company-employed authors or analysis/reporting involvement is established." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "What public sport/university support did Fyfe record?", "needed": "Support wording and actual roles", "role": "Required", "role_reason": "This condition connects Support wording and actual roles with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Support wording and actual roles must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Fyfe support, affiliations, interests and role material. Parent independence axes remain distinct from actual support-verification scope. This records needed materials; no new research was executed.", "current_reports": [ "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve Fyfe original public sport/university support wording. This does not establish current industry-independence certification or the absence of every product-support/company role.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Fyfe support, affiliations, interests and role material. Parent independence axes remain distinct from actual support-verification scope.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Fyfe support, affiliations, interests and role material. Parent independence axes remain distinct from actual support-verification scope." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "Were injury withdrawals kept distinct from cold causation?", "needed": "Original withdrawal, safety and causal assessment", "role": "Supplementary", "role_reason": "This condition connects Original withdrawal, safety and causal assessment with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original withdrawal, safety and causal assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original withdrawal, safety and cause-assessment material. No new attrition counts/rates or medical causal judgments are created. This records needed materials; no new research was executed.", "current_reports": [ "S01" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "The original did not attribute unrelated-injury withdrawal to cold immersion. Exact arm-specific causes, timing, analysis handling and exposure causality are unverified.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Original withdrawal, safety and cause-assessment material. No new attrition counts/rates or medical causal judgments are created.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Original withdrawal, safety and cause-assessment material. No new attrition counts/rates or medical causal judgments are created." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "Were medical harms, missing data and vulnerable populations verified?", "needed": "Harm collection, events, denominators and other populations", "role": "Supplementary", "role_reason": "This condition connects Harm collection, events, denominators and other populations with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Harm collection, events, denominators and other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific safety collection, events/denominators and longer-term material. Unverified/missing data do not establish 0 events or safety. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent Caution and unverified medical adverse-event rates/safety across diseases. Arm-specific collection, event counts/denominators, missing data and longer-term/vulnerable-population outcomes are unverified.", "condition_status": "Unverified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Report-specific safety collection, events/denominators and longer-term material. Unverified/missing data do not establish 0 events or safety.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Report-specific safety collection, events/denominators and longer-term material. Unverified/missing data do not establish 0 events or safety." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "How are bilingual text, original direction, historical checks and corrections retained?", "needed": "Original values, evidence date and absent subclaim fields", "role": "Required", "role_reason": "This condition connects Original values, evidence date and absent subclaim fields with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original values, evidence date and absent subclaim fields must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual comments, corrections, follow-up material and complete prior originals. Material additions, condition revisions and verdict changes remain separate events. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "Preserve parent grade D with 28 points/E-, Korean/English wording, 2026-09-07, empty correction array/deliberation note and selected subclaim D/note with absent score/status/axes. Historical verification is not labeled as completed current content review.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Actual comments, corrections, follow-up material and complete prior originals. Material additions, condition revisions and verdict changes remain separate events.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual comments, corrections, follow-up material and complete prior originals. Material additions, condition revisions and verdict changes remain separate events." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "Which materials were actually read?", "needed": "Stored summaries versus unread external originals", "role": "Required", "role_reason": "This condition connects Stored summaries versus unread external originals with the selected muscle-loss/universal-strength claim, boundaries with actual gains and maximum-strength results, measurements/denominators, training/exposure/controls, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that both groups gained muscle and maximum-strength results differed. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/E- context. Gain differences do not establish actual loss; less type II hypertrophy does not establish universal strength impairment. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Stored summaries versus unread external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual originals, registration, planning/support material and reading records. Original bibliographies/PMCIDs do not establish acquisition, full-text reading or new verification. This records needed materials; no new research was executed.", "current_reports": [ "S01", "S02" ], "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "observation": "This work read summaries/bibliographies in the complete preserved JSON to create reader material. External abstracts, full texts, registration, planning and support material remain unread; no access was attempted.", "condition_status": "Partly verified", "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.", "missingness": "Actual originals, registration, planning/support material and reading records. Original bibliographies/PMCIDs do not establish acquisition, full-text reading or new verification.", "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.", "review_date": null, "reading_status": "Full text not read · Stored summary read", "additional_material": "Actual originals, registration, planning/support material and reading records. Original bibliographies/PMCIDs do not establish acquisition, full-text reading or new verification." } ], "reports": [ { "report_id": "S01", "title": "Roberts LA et al. Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. J Physiol. 2015;593(18):4285-4301. PMID: 26174323. PMCID: PMC4594298. DOI: 10.1113/JP270570.", "url": "https://pubmed.ncbi.nlm.nih.gov/26174323/", "report_type": "Twelve-week active-recovery controlled resistance-training trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S01; unique counts and independent replication unverified", "independent_replication": "Roberts and Fyfe have separate preserved bibliographies; the parent and both subclaim sheets share these reports. Roberts longer-term MRI/strength and acute signaling, and Fyfe fiber/strength outcomes are different results. Acute/longer-term cohort relationships, overlap with related reports and unique-trial/participant totals are unverified. Multiple measures, subgroups, repeated measurements, sheets and reports are not summed into new participants or independent replications. These delimit the selected broader claim; gains in both groups and strength disagreement do not create new independence certification.", "observed_result": "Active recovery 309±73 g vs CWI 103±71 g; difference -206 g, P<.001", "result_level": "For the selected muscle-loss claim, this delimits a comparison of gains. Preserve 12 weeks, 24 assigned/21 completed, active recovery 309±73 g versus CWI 103±71 g, original difference -206 g/P<.001 and parent d=-4.1. Both groups gained muscle. The meaning of ±, arm-/measurement-specific denominators, 95% CIs and prospective hierarchy are unverified; no new difference or attrition count/rate is calculated.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 26174323, DOI 10.1113/JP270570, PMCID PMC4594298 and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/26174323/" } ] }, { "report_id": "S02", "title": "Fyfe JJ et al. Cold water immersion attenuates anabolic signaling and skeletal muscle fiber hypertrophy, but not strength gain, following whole-body resistance training. J Appl Physiol. 2019;127(5):1403-1418. PMID: 31513450. DOI: 10.1152/japplphysiol.00127.2019.", "url": "https://pubmed.ncbi.nlm.nih.gov/31513450/", "report_type": "Seven-week passive-rest controlled resistance-training trial", "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.", "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread", "study_family": "Original report S02; unique counts and independent replication unverified", "independent_replication": "Roberts and Fyfe have separate preserved bibliographies; the parent and both subclaim sheets share these reports. Roberts longer-term MRI/strength and acute signaling, and Fyfe fiber/strength outcomes are different results. Acute/longer-term cohort relationships, overlap with related reports and unique-trial/participant totals are unverified. Multiple measures, subgroups, repeated measurements, sheets and reports are not summed into new participants or independent replications. These delimit the selected broader claim; gains in both groups and strength disagreement do not create new independence certification.", "observed_result": "Less type II hypertrophy; no clear maximum-strength attenuation", "result_level": "For the selected universal-strength claim, this delimits scope. Preserve both less type II hypertrophy and no clear maximum-strength attenuation in the separate 16-participant, 7-week trial. Exact measure-specific values, effects/CIs, denominators and prospective hierarchy are unverified. Fiber area is not converted into MRI grams or the same effect across all strength outcomes/sports.", "source_evidence_date": "2026-09-07", "materials": [ { "material_type": "Stored existing review summary", "public_status": "Preserved copy of the complete parent-verdict stored summary", "access_status": "Stored summary", "acquired": true, "actually_read": "Summary read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "External paper", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Registration material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Protocol", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Statistical analysis plan", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." }, { "material_type": "Funding, product-support and COI material", "public_status": "Original bibliographic link or needed material; external public availability/access status unverified", "access_status": "Unread; access not attempted", "acquired": false, "actually_read": "Not read", "as_of": "2026-09-07", "qualification": "Preserve original PubMed URL, PMID 31513450, DOI 10.1152/japplphysiol.00127.2019, PMCID unrecorded and bibliographic wording unchanged. Original evidence summaries lack a registration-identifier field and citation registration wording is unrecorded. This does not establish no registration; no new identifier/URL, prospective status or external reading is inferred." } ], "links": [ { "label": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/31513450/" } ] } ], "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Met": "A state used when required evidence is confirmed after user review. This production does not declare that review complete.", "Partly verified": "Some information in the stored summary is linked into the table. External comparison/content review is not complete.", "Unverified": "The article leaves this unverified, or required material is absent from the current stored summary. This is distinct from zero, absence or safety.", "Review incomplete": "User review pending.", "Not reported": "Not reported within the stored material actually read; not extended to the entire primary paper.", "Inaccessible": "Means an actual access failure. Access not attempted here is not assigned this state.", "Not applicable": "Not used as a substitute for an evidence gap.", "Conflicting data": "Requires an observed disagreement under the same comparison criteria; not automatically judged in this production.", "Insufficient evidence for the conditions": "Marks a gap in additional material required by the selected conditions; not a new efficacy grade." }, "study_overlap": { "state": "Unverified", "unique_trial_count": null, "unique_participant_count": null, "reason": "Roberts and Fyfe have separate preserved bibliographies; the parent and both subclaim sheets share these reports. Roberts longer-term MRI/strength and acute signaling, and Fyfe fiber/strength outcomes are different results. Acute/longer-term cohort relationships, overlap with related reports and unique-trial/participant totals are unverified. Multiple measures, subgroups, repeated measurements, sheets and reports are not summed into new participants or independent replications. These delimit the selected broader claim; gains in both groups and strength disagreement do not create new independence certification." }, "history": [ { "date": "2026-10-16", "kind": "Separation of public-facing pages and materials", "view_version": "1.0", "change": "Public pages and materials were prepared from the existing 24 items. No new clinical search, verification-status change or scoring was performed." } ], "language": "en", "translation_date": "2026-10-16" }