{ "schema_version": "chamgap-public-criteria-1.0", "title": "Repeated post-exercise cold immersion × smaller hypertrophy gains", "language": "en", "translation_date": "2026-10-16", "criteria_version": "1.0", "criteria_date": "2026-10-06", "condition_origin": "Chamgap's own application conditions", "method_sources": [ { "id": "M03", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03", "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13", "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M04", "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04", "section": "§4.5, §4.6.1–4.6.3, MECIR C42", "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M08", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08", "section": "§8.1–8.2.3, Table 8.2.a", "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M15", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15", "section": "§15.2.4, §15.3.1–15.3.3", "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." }, { "id": "M19", "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10", "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19", "section": "§19.1.2, §19.2.1–19.2.4", "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.", "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed." } ], "status_dictionary": { "Met": "The original content has been reviewed as meeting the conditions. This status is not used in this preparation.", "Partly verified": "Some information in the stored summary was linked during preparation; clinical verification or review is not complete.", "Unverified": "Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.", "Review incomplete": "Awaiting user review, or actual review remains incomplete.", "Not reported": "Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.", "Inaccessible": "Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.", "Insufficient evidence for the conditions": "Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.", "Not applicable": "Used when the reason it does not apply to the original question is stated.", "Conflicting data": "Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment." }, "requirements": [ { "item_id": "N01", "question_type": "Evidence condition", "question": "Which hypertrophy-gain claim is being checked?", "needed": "Selected subclaim and boundaries with other outcomes", "role": "Required", "role_reason": "This condition connects Selected subclaim and boundaries with other outcomes with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Selected subclaim and boundaries with other outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original subclaim record and hypertrophy endpoint plans. Muscle loss, all strength outcomes and acute recovery remain distinct. This records needed materials; no new research was executed." }, { "item_id": "N02", "question_type": "Evidence condition", "question": "Is subclaim D distinct from parent grade D with 28 points?", "needed": "Original grade, direction and absent values", "role": "Required", "role_reason": "This condition connects Original grade, direction and absent values with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original grade, direction and absent values must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original verdict, direction, subclaim records and correction material. Parent values do not fill absent subclaim values. This records needed materials; no new research was executed." }, { "item_id": "N03", "question_type": "Evidence condition", "question": "Which trainees provide the hypertrophy data?", "needed": "Population, training history and baseline conditions", "role": "Required", "role_reason": "This condition connects Population, training history and baseline conditions with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Population, training history and baseline conditions must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original population, exclusion, training-history and baseline nutrition/disease tables. A representative population is not assigned to every report. This records needed materials; no new research was executed." }, { "item_id": "N04", "question_type": "Evidence condition", "question": "What were the original repeated-cold-immersion specifications?", "needed": "Cold exposure specifications and actual adherence", "role": "Required", "role_reason": "This condition connects Cold exposure specifications and actual adherence with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Cold exposure specifications and actual adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exposure specifications, actual temperature, adherence and interruption records. Research specifications are not new cold-water instructions. This records needed materials; no new research was executed." }, { "item_id": "N05", "question_type": "Evidence condition", "question": "How do training region, repetition and duration differ?", "needed": "Training programs and outcome timing", "role": "Required", "role_reason": "This condition connects Training programs and outcome timing with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Training programs and outcome timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Training protocols, load/progression, adherence and measurement times. Different programs are not combined as the same exposure. This records needed materials; no new research was executed." }, { "item_id": "N06", "question_type": "Evidence condition", "question": "What comparison does active recovery provide?", "needed": "Roberts control and accompanying management", "role": "Required", "role_reason": "This condition connects Roberts control and accompanying management with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Roberts control and accompanying management must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Control specifications, activity/contact and shared training/nutrition records. Active recovery is not substituted for passive rest. This records needed materials; no new research was executed." }, { "item_id": "N07", "question_type": "Evidence condition", "question": "What are the passive-rest control and different cold specifications?", "needed": "Fyfe intervention, control and duration", "role": "Required", "role_reason": "This condition connects Fyfe intervention, control and duration with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Fyfe intervention, control and duration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Fyfe intervention, control, adherence, training and original outcome tables. Temperatures, times and controls remain report-specific. This records needed materials; no new research was executed." }, { "item_id": "N08", "question_type": "Evidence condition", "question": "What outcome is MRI quadriceps gain?", "needed": "MRI measurement and change derivation", "role": "Required", "role_reason": "This condition connects MRI measurement and change derivation with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for MRI measurement and change derivation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original MRI tables, measurement/derivation procedures, baseline/end values and denominators. These are not converted into other muscles or strength outcomes. This records needed materials; no new research was executed." }, { "item_id": "N09", "question_type": "Evidence condition", "question": "What are the arm-specific gains and P value?", "needed": "Original MRI values, difference and uncertainty", "role": "Required", "role_reason": "This condition connects Original MRI values, difference and uncertainty with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original MRI values, difference and uncertainty must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original MRI outcome tables, legends, tests, denominators and intervals. ± is not read as a CI and no new difference is calculated. This records needed materials; no new research was executed." }, { "item_id": "N10", "question_type": "Evidence condition", "question": "What original record contains d=-4.1?", "needed": "Definition and derivation of the original effect size", "role": "Required", "role_reason": "This condition connects Definition and derivation of the original effect size with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Definition and derivation of the original effect size must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original effect derivation, models, intervals and denominators. No new d or CI is estimated. This records needed materials; no new research was executed." }, { "item_id": "N11", "question_type": "Evidence condition", "question": "Were 95% CIs and prospective primary hierarchy verified?", "needed": "Prospective hierarchy, intervals and sample-size rationale", "role": "Required", "role_reason": "This condition connects Prospective hierarchy, intervals and sample-size rationale with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Prospective hierarchy, intervals and sample-size rationale must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration, protocols, SAPs, original intervals and sample-size rationale. Metadata and verification of prospective plans remain distinct. This records needed materials; no new research was executed." }, { "item_id": "N12", "question_type": "Evidence condition", "question": "How does less gain differ from muscle loss?", "needed": "Change from baseline and between-group comparison", "role": "Required", "role_reason": "This condition connects Change from baseline and between-group comparison with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Change from baseline and between-group comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original baseline, end/change tables and analysis scope. Smaller gains are not converted into negative change from baseline. This records needed materials; no new research was executed." }, { "item_id": "N13", "question_type": "Evidence condition", "question": "Is type II hypertrophy the same as MRI grams?", "needed": "Fiber area versus MRI", "role": "Required", "role_reason": "This condition connects Fiber area versus MRI with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Fiber area versus MRI must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original fiber tables, measurement/derivation, regions and denominators/CIs. Fiber area is not converted into MRI grams. This records needed materials; no new research was executed." }, { "item_id": "N14", "question_type": "Evidence condition", "question": "How do maximum-strength outcomes differ from hypertrophy?", "needed": "Strength-specific results and disagreement", "role": "Required", "role_reason": "This condition connects Strength-specific results and disagreement with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Strength-specific results and disagreement must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original tables, models, denominators and intervals for each strength measure. Null results do not establish 0 effect, equivalence or impairment of all strength outcomes. This records needed materials; no new research was executed." }, { "item_id": "N15", "question_type": "Evidence condition", "question": "Does acute anabolic signaling replace longer-term hypertrophy?", "needed": "Linkage of acute/longer-term outcomes and samples", "role": "Required", "role_reason": "This condition connects Linkage of acute/longer-term outcomes and samples with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Linkage of acute/longer-term outcomes and samples must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Within-report acute/longer-term distinctions, sample/timing and identity material. Titles alone do not create acute values or new trials. This records needed materials; no new research was executed." }, { "item_id": "N16", "question_type": "Evidence condition", "question": "Are perceived recovery/soreness and hypertrophy the same goal?", "needed": "Boundaries between acute recovery and longer-term adaptation", "role": "Required", "role_reason": "This condition connects Boundaries between acute recovery and longer-term adaptation with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Boundaries between acute recovery and longer-term adaptation must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Outcome definitions, timing and cohort material for the same/different questions. Acute recovery is not transferred into hypertrophy benefit. This records needed materials; no new research was executed." }, { "item_id": "N17", "question_type": "Evidence condition", "question": "Which stage does the assigned count of 24 describe?", "needed": "Recruitment/allocation flow and procedures", "role": "Required", "role_reason": "This condition connects Recruitment/allocation flow and procedures with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Recruitment/allocation flow and procedures must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm-specific flowcharts, allocation/recruitment and procedures. Overall counts are not automatically assigned as arm or endpoint denominators. This records needed materials; no new research was executed." }, { "item_id": "N18", "question_type": "Evidence condition", "question": "Are 21 completers linked to measurement-specific denominators?", "needed": "Complete-case analysis and outcome denominators", "role": "Required", "role_reason": "This condition connects Complete-case analysis and outcome denominators with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Complete-case analysis and outcome denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm denominators, flow and exclusions in original MRI/strength tables. Completer counts do not replace every outcome's analysis denominator. This records needed materials; no new research was executed." }, { "item_id": "N19", "question_type": "Evidence condition", "question": "Were withdrawal causes kept distinct from cold-induced harm?", "needed": "Injury/withdrawal causes and timing", "role": "Required", "role_reason": "This condition connects Injury/withdrawal causes and timing with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Injury/withdrawal causes and timing must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Flowcharts, injury/withdrawal causes, timing and analysis handling. No new attrition counts/rates or causal judgment are created. This records needed materials; no new research was executed." }, { "item_id": "N20", "question_type": "Evidence condition", "question": "Are 16 participants the fiber/strength denominators?", "needed": "Fyfe flow and measurement-specific denominators", "role": "Required", "role_reason": "This condition connects Fyfe flow and measurement-specific denominators with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Fyfe flow and measurement-specific denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Flow, measurement denominators, missing data and analyses. Overall sample size does not replace all endpoint denominators. This records needed materials; no new research was executed." }, { "item_id": "N21", "question_type": "Evidence condition", "question": "What do completer, assigned and actual-use analyses estimate?", "needed": "Analysis populations, missingness and sensitivity", "role": "Required", "role_reason": "This condition connects Analysis populations, missingness and sensitivity with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Analysis populations, missingness and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: SAPs, actual models, analysis populations and missingness/sensitivity material. No new analysis or adjustment is executed. This records needed materials; no new research was executed." }, { "item_id": "N22", "question_type": "Evidence condition", "question": "How were MRI, biopsy and strength assessed?", "needed": "Measurement, allocation awareness and reliability", "role": "Required", "role_reason": "This condition connects Measurement, allocation awareness and reliability with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Measurement, allocation awareness and reliability must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Measurement procedures, assessor/analyst records and repetition/reliability. Measurement names alone do not certify blinding or precision. This records needed materials; no new research was executed." }, { "item_id": "N23", "question_type": "Evidence condition", "question": "Are contributions of nutrition products, diet and training management known?", "needed": "Nutrition, load, adherence and shared management", "role": "Required", "role_reason": "This condition connects Nutrition, load, adherence and shared management with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Nutrition, load, adherence and shared management must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Nutrition, supplements, training/adherence and shared-management records. Product provision does not establish matched intake or a separate effect. This records needed materials; no new research was executed." }, { "item_id": "N24", "question_type": "Evidence condition", "question": "How does an absent registration field differ from prospective endpoint verification?", "needed": "Registration identity, content, timing and plans", "role": "Required", "role_reason": "This condition connects Registration identity, content, timing and plans with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Registration identity, content, timing and plans must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration, protocols, SAPs and changes linked to the papers. An absent field does not establish no registration or prospective verification. This records needed materials; no new research was executed." }, { "item_id": "N25", "question_type": "Evidence condition", "question": "How are longer-term, acute and multiple outcomes in the same report linked?", "needed": "Overlap across reports, cohorts and outcomes", "role": "Required", "role_reason": "This condition connects Overlap across reports, cohorts and outcomes with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Overlap across reports, cohorts and outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Registration, recruitment dates and report/cohort/outcome identity. Multiple outcomes or both sheets are not summed as new participants or independent trials. This records needed materials; no new research was executed." }, { "item_id": "N26", "question_type": "Evidence condition", "question": "What verification level applies to support, interests and original I1?", "needed": "Support, in-kind provision, company roles and historical values", "role": "Required", "role_reason": "This condition connects Support, in-kind provision, company roles and historical values with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Support, in-kind provision, company roles and historical values must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Support/interest declarations, product distribution, affiliations and investigator roles. No new absence of company-employed authors or analysis/publication involvement is established. This records needed materials; no new research was executed." }, { "item_id": "N27", "question_type": "Evidence condition", "question": "Can two supportive directions generalize to every exposure/population?", "needed": "Directness of measures, controls, training and exposure", "role": "Required", "role_reason": "This condition connects Directness of measures, controls, training and exposure with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Directness of measures, controls, training and exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Condition-specific original tables, measurements/comparisons and identity material. Different supportive directions are not calculated as one pooled effect. This records needed materials; no new research was executed." }, { "item_id": "N28", "question_type": "Evidence condition", "question": "What persists after exposure and under other conditions?", "needed": "Post-training outcomes, other exposures and subgroups", "role": "Required", "role_reason": "This condition connects Post-training outcomes, other exposures and subgroups with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Post-training outcomes, other exposures and subgroups must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original post-training, other-exposure and subgroup data. No sustained effect beyond original durations is created. This records needed materials; no new research was executed." }, { "item_id": "N29", "question_type": "Evidence condition", "question": "Do hypertrophy measures answer medical-injury or disease-safety questions?", "needed": "Adverse training-goal adaptation versus medical harm", "role": "Required", "role_reason": "This condition connects Adverse training-goal adaptation versus medical harm with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Adverse training-goal adaptation versus medical harm must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Separate harm/disease-population reports, exposure, events and denominators. Goal-related disadvantage is not converted into medical-harm incidence. This records needed materials; no new research was executed." }, { "item_id": "N30", "question_type": "Evidence condition", "question": "What material was actually read here?", "needed": "Reading scope of stored summaries and external originals", "role": "Required", "role_reason": "This condition connects Stored summaries versus external originals with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Reading scope of stored summaries and external originals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Report-specific abstracts, full texts, registration/plans, original tables, support material and actual reading records. Bibliography/PMCID presence does not mean full-text reading. This records needed materials; no new research was executed." }, { "item_id": "N31", "question_type": "Evidence condition", "question": "Are historical verification and current production/review distinct?", "needed": "Original evidence date, corrections and historical checks", "role": "Required", "role_reason": "This condition connects Original evidence date, corrections and historical checks with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original evidence date, corrections and historical checks must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Complete actual correction/evidence-update records. Original dates are not production/review dates and do not certify no external corrections. This records needed materials; no new research was executed." }, { "item_id": "N32", "question_type": "Evidence condition", "question": "Were gain/loss boundaries in both original languages preserved?", "needed": "Correspondence of original languages and scope", "role": "Required", "role_reason": "This condition connects Correspondence of original languages and scope with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Correspondence of original languages and scope must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Complete needed original reports, translations and corrections. Original bilingual distinctions do not create new verification or broader claims. This records needed materials; no new research was executed." }, { "item_id": "N33", "question_type": "Evidence condition", "question": "How are parent axes and absent subclaim values retained?", "needed": "Original axes and selected-field boundaries", "role": "Required", "role_reason": "This condition connects Original axes and selected-field boundaries with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original axes and selected-field boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Actual axis/subclaim-record correction material. Parent axes/scores do not fill absent subclaim values. This records needed materials; no new research was executed." }, { "item_id": "N34", "question_type": "Evidence condition", "question": "Which medical adverse events were collected?", "needed": "Harm definitions, collection, assessment and original events", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Harm definitions, collection, assessment and original events with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Harm definitions, collection, assessment and original events must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Harm definitions, collection and withdrawal/event tables. Caution does not establish actual incidence, no harm or safety certification. This records needed materials; no new research was executed." }, { "item_id": "N35", "question_type": "Evidence condition", "question": "How do exposure, injury, interruption and follow-up times differ?", "needed": "Exposure duration versus event/follow-up time", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Exposure duration versus event/follow-up time with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Exposure duration versus event/follow-up time must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Exposure, event, interruption and later timelines. Training duration is not substituted for harm follow-up duration. This records needed materials; no new research was executed." }, { "item_id": "N36", "question_type": "Evidence condition", "question": "Were harms compared equally with active/passive controls?", "needed": "Arm-specific harm collection, duration and direct comparison", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Arm-specific harm collection, duration and direct comparison with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Arm-specific harm collection, duration and direct comparison must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Arm-specific harm collection, periods and withdrawal/event tables. A control arm alone does not establish matched collection or a direct risk comparison. This records needed materials; no new research was executed." }, { "item_id": "N37", "question_type": "Evidence condition", "question": "What are harm event counts and exposure/observation denominators?", "needed": "Original medical-harm events and denominators", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Original medical-harm events and denominators with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Original medical-harm events and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Original harm tables, actual exposure/observation flow and interruptions. Trial counts do not establish harm denominators or 0 events. This records needed materials; no new research was executed." }, { "item_id": "N38", "question_type": "Evidence condition", "question": "Are injury, training load, nutrition and exposure causality distinguished?", "needed": "Baseline risk, accompanying management and causal assessment", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Baseline risk, accompanying management and causal assessment with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Baseline risk, accompanying management and causal assessment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Injury timing, training/nutrition, baseline risks and causal-assessment records. No new medical causality is established. This records needed materials; no new research was executed." }, { "item_id": "N39", "question_type": "Evidence condition", "question": "Are interruptions/withdrawals linked to missing harm data?", "needed": "Interruption, data loss, selective reporting and follow-up", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Interruption, data loss, selective reporting and follow-up with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Interruption, data loss, selective reporting and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Interruption/withdrawal reasons, harm records, follow-up and published tables. Missing data do not establish no harm. This records needed materials; no new research was executed." }, { "item_id": "N40", "question_type": "Evidence condition", "question": "What independent, disease-population or later harm material is available?", "needed": "Direct medical-harm evidence and other populations", "role": "Supplementary; required for extending medical safety conclusions", "role_reason": "This condition connects Direct medical-harm evidence and other populations with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Direct medical-harm evidence and other populations must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Related harm/disease-population, exposure/collection/denominator and later material. No safety or risk certification beyond the original scope is created. This records needed materials; no new research was executed." }, { "item_id": "N41", "question_type": "Evidence condition", "question": "Are conditions, method copies, application and review separate?", "needed": "Condition freezing, observations and change records", "role": "Required", "role_reason": "This condition connects Condition freezing, observations and change records with hypertrophy gains under repeated cold immersion, MRI/fiber/strength/acute outcomes, exposure, training, controls, nutrition, assigned/completer/measurement denominators, support and medical harms.", "application_exception": "Preserve selected subclaim D and the original note that two small trials supported an adverse E- direction. Distinguish absent subclaim score/status/axes from parent grade D with 28 points/Caution. Preserve original gain differences, signs, P values and d without turning them into muscle loss or impairment of every strength outcome. Create no new effects, CIs, attrition counts/rates, totals, grades, independence/safety certification or cold-water, exercise, recovery or treatment instructions.", "criterion": "Material for Condition freezing, observations and change records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.", "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.", "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.", "proposed_research": "Material needed: Complete new reports, registration, corrections and original tables, plus full prior originals, condition versions, application and review records. Material additions, condition revisions and verdict changes remain separate events. This records needed materials; no new research was executed." } ] }