{
  "schema_version": "chamgap-public-evidence-check-1.0",
  "public_id": "v2997-s1",
  "verdict_number": "2997",
  "title": "Long-term whey alone × HbA1c and complication outcomes",
  "view_version": "1.0",
  "view_created_date": "2026-10-16",
  "criteria_version": "1.0",
  "criteria_date": "2026-10-06",
  "review_date": null,
  "legacy_evidence_date": "2026-09-07",
  "review_scope": {
    "materials_read": "Existing review summaries and stored records of methodological application",
    "clinical_papers_directly_read": false,
    "new_clinical_search": false,
    "limitation": "Existing stored summary and preserved methodology application records. External papers, abstracts, registration, protocols, SAPs, original result tables and support disclosures are unread, and review of existing content remains incomplete.",
    "date_meaning": "This is the date the stored materials were checked, not the date of a new search of the clinical literature."
  },
  "claim_context": {
    "population": "The selected question concerns long-term whey alone in adults with type 2 diabetes. Parent non-insulin-treated context and acute 15-person/7-day 18-person samples are short-term background. Long-term whey-only eligibility, baseline HbA1c, medication, renal/complication risks and arm-specific completion/analysis denominators are unverified.",
    "intervention": "Actual long-term whey-only product, formulation, components, dose and exposure are unverified. Whey plus guar and MCT plus WPI are different combinations. Do not copy original short-term 50 g or 15.6 g protein-drink specifications into a long-term whey-only intervention.",
    "dose": "Selected long-term whey-only dose, premeal timing, actual intake and adherence are unverified. Parent 10–30 minutes before meals, acute 50 g/30 minutes before a meal and premeal 15.6 g identify short-term research. No new long-term totals, cumulative exposure or dosing instructions are calculated or created.",
    "comparator": "Long-term whey-only comparators, isocaloric/nutrient composition, meals, lifestyle, medication and contact conditions are unverified. The 7-day approximately 100 kcal versus 34 kcal non-isocaloric drink comparison or other combination controls do not supply that direct comparison.",
    "endpoint": "Long-term whey-only HbA1c and complication definitions, units, assessment/adjudication, direct arm-specific effects/CIs and denominators are separately unverified. Do not transfer acute 180-minute glucose 28% lower, insulin 105% higher and a GLP-1 increase, 7-day iAUC 1.6±0.6 versus 2.1±0.9/P=.003, or null primary MCT-plus-WPI iAUC into direct long-term outcomes.",
    "duration": "Exact long-term whey-only intervention duration, HbA1c assessment times, complication observation windows and post-intervention follow-up are unverified. Original acute 180-minute/7-day exposure and combination 24-hour/daytime iAUC are different background scopes and do not establish long-term follow-up duration.",
    "excluded_extensions": [
      "Transferring acute/7-day glucose, iAUC or hormones into long-term whey-only HbA1c or complications",
      "Calculating isolated whey contributions/effects from guar or MCT-plus-WPI combinations",
      "Treating null primary combination results as long-term whey-only null effects, zero effect or equivalence",
      "Summing reports, sheets, crossover periods or outcomes into new unique-trial, participant or independent-replication totals",
      "Inheriting parent C50, axes or historical verification as missing subclaim-? values, new review or a new verdict",
      "Creating new numbers, effects/CIs, grades, independence certification, dosing, meal/medication reduction/replacement or treatment guidance"
    ]
  },
  "requirements": [
    {
      "item_id": "N01",
      "question_type": "Evidence condition",
      "question": "Which original long-term subclaim is being checked?",
      "needed": "Original long-term claim and its boundary with parent/short-term context",
      "role": "Required",
      "role_reason": "This condition connects Original long-term claim and its boundary with parent/short-term context with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original long-term claim and its boundary with parent/short-term context must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct long-term whey-only endpoint and analysis material is unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected claim is long-term whey-only HbA1c or complication benefit. The parent and other short-term subclaim concern acute or several-day postprandial glucose. Leave separate direct evidence needs for long-term whey-only HbA1c and complications.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct long-term whey-only endpoint and analysis material is unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct long-term whey-only endpoint and analysis material is unverified."
    },
    {
      "item_id": "N02",
      "question_type": "Evidence condition",
      "question": "Are subclaim ? and parent C50 separate?",
      "needed": "Original ? and note, absent score/status, and parent C50/safety",
      "role": "Required",
      "role_reason": "This condition connects Original ? and note, absent score/status, and parent C50/safety with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original ? and note, absent score/status, and parent C50/safety must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Subclaim score/status fields are absent. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected long-term subclaim is graded ?, with an original note that longer trials used combinations and cannot isolate whey. Score/status are absent. Parent C50 is historical short-term postprandial-glucose context.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Subclaim score/status fields are absent.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Subclaim score/status fields are absent."
    },
    {
      "item_id": "N03",
      "question_type": "Evidence condition",
      "question": "Who is the long-term whey-only question about?",
      "needed": "Adults with type 2 diabetes, original non-insulin-treated context and long-term eligibility",
      "role": "Required",
      "role_reason": "This condition connects Adults with type 2 diabetes, original non-insulin-treated context and long-term eligibility with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Adults with type 2 diabetes, original non-insulin-treated context and long-term eligibility must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only populations, baseline/complication status, treatment and exclusions are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The research description concerns non-insulin-treated adults; individual evidence entries say adults with type 2 diabetes or 18 participants. Long-term whey-only eligibility, age, baseline HbA1c, medication and complication-risk populations are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only populations, baseline/complication status, treatment and exclusions are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only populations, baseline/complication status, treatment and exclusions are unverified."
    },
    {
      "item_id": "N04",
      "question_type": "Evidence condition",
      "question": "Are long-term whey alone and combinations different interventions?",
      "needed": "Whey formulation/ingredient, WPI, guar/MCT and long-term whey-only specifications",
      "role": "Required",
      "role_reason": "This condition connects Whey formulation/ingredient, WPI, guar/MCT and long-term whey-only specifications with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Whey formulation/ingredient, WPI, guar/MCT and long-term whey-only specifications must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only formulation, components, dose, isolated comparison and actual adherence are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original key explanation, research description and product information distinguish whey plus guar and MCT plus WPI from whey alone. Selected long-term whey-only formulation, components, dose and actual exposure are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only formulation, components, dose, isolated comparison and actual adherence are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only formulation, components, dose, isolated comparison and actual adherence are unverified."
    },
    {
      "item_id": "N05",
      "question_type": "Evidence condition",
      "question": "What are the actual long-term duration and observation windows?",
      "needed": "Long-term exposure/follow-up, HbA1c times, complication windows and post-intervention follow-up",
      "role": "Required",
      "role_reason": "This condition connects Long-term exposure/follow-up, HbA1c times, complication windows and post-intervention follow-up with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Long-term exposure/follow-up, HbA1c times, complication windows and post-intervention follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only exposure/follow-up, assessment times and event windows are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected subclaim/parent describe uncertain long-term whey-only effects. Exact long-term duration, HbA1c assessment dates and complication windows are absent from the stored summary. The acute 180-minute summary and Smith's 7 days are short-term background.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only exposure/follow-up, assessment times and event windows are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only exposure/follow-up, assessment times and event windows are unverified."
    },
    {
      "item_id": "N06",
      "question_type": "Evidence condition",
      "question": "How is long-term HbA1c defined?",
      "needed": "HbA1c units, baseline/end/change, times, measurement and model",
      "role": "Required",
      "role_reason": "This condition connects HbA1c units, baseline/end/change, times, measurement and model with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for HbA1c units, baseline/end/change, times, measurement and model must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Whey-only HbA1c definitions/units, baseline/change, times and models are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected subclaim includes an HbA1c question, but the three reports' endpoints are acute glucose/hormones, postprandial iAUC/time above range and 24-hour/daytime iAUC. Long-term whey-only HbA1c definitions, measurement, units and times are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Whey-only HbA1c definitions/units, baseline/change, times and models are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Whey-only HbA1c definitions/units, baseline/change, times and models are unverified."
    },
    {
      "item_id": "N07",
      "question_type": "Evidence condition",
      "question": "Is a between-group long-term whey-only HbA1c effect preserved?",
      "needed": "Long-term whey-only arm values, between-group effect, adjustment/CI and control",
      "role": "Required",
      "role_reason": "This condition connects Long-term whey-only arm values, between-group effect, adjustment/CI and control with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Long-term whey-only arm values, between-group effect, adjustment/CI and control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only arm values, effects/CIs, adjustment and comparator are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original subclaim note says longer combination trials prevent isolating whey. Stored material lacks a long-term whey-only between-group HbA1c effect, CI or adjusted estimate. This is unverified within the present preservation/reading scope.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only arm values, effects/CIs, adjustment and comparator are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only arm values, effects/CIs, adjustment and comparator are unverified."
    },
    {
      "item_id": "N08",
      "question_type": "Evidence condition",
      "question": "What are long-term HbA1c populations, denominators and missing data?",
      "needed": "Allocation/completion/analysis, arm-specific sample sizes, medication, missing data and ITT/PP",
      "role": "Required",
      "role_reason": "This condition connects Allocation/completion/analysis, arm-specific sample sizes, medication, missing data and ITT/PP with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Allocation/completion/analysis, arm-specific sample sizes, medication, missing data and ITT/PP must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only arm-specific analysis/denominators, missing data/attrition and target effects are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original sample sizes exist for acute 15-person and 7-day 18-person studies. Zameer's sample wording only says adults with type 2 diabetes. Long-term whey-only HbA1c arm-specific allocation/completion/analysis counts and attrition/missing-data handling are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only arm-specific analysis/denominators, missing data/attrition and target effects are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only arm-specific analysis/denominators, missing data/attrition and target effects are unverified."
    },
    {
      "item_id": "N09",
      "question_type": "Evidence condition",
      "question": "Which complications and follow-up windows are being asked about?",
      "needed": "Complication definitions, collection/adjudication, occurrence/progression and follow-up",
      "role": "Required",
      "role_reason": "This condition connects Complication definitions, collection/adjudication, occurrence/progression and follow-up with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Complication definitions, collection/adjudication, occurrence/progression and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct complication definitions, collection/adjudication, occurrence/progression and follow-up are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected subclaim includes complication benefit, but specific event definitions, occurrence/progression, collection/adjudication and follow-up windows are absent. The original counterpoint/synthesis distinguishes insulin/GLP-1 from clinical complication outcomes.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct complication definitions, collection/adjudication, occurrence/progression and follow-up are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct complication definitions, collection/adjudication, occurrence/progression and follow-up are unverified."
    },
    {
      "item_id": "N10",
      "question_type": "Evidence condition",
      "question": "Are direct complication effects, denominators and CIs available?",
      "needed": "Whey-only arm-specific events/denominators, effects/CIs, losses and comparator/medication",
      "role": "Required",
      "role_reason": "This condition connects Whey-only arm-specific events/denominators, effects/CIs, losses and comparator/medication with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Whey-only arm-specific events/denominators, effects/CIs, losses and comparator/medication must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct complication events/denominators, effects/CIs, follow-up losses and comparator are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original summary does not preserve long-term whey-only complication event counts, denominators or effects/CIs. Original advertising-boundary and summary wording describe the problem of extending short-term signals into treatment or long-term benefit.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct complication events/denominators, effects/CIs, follow-up losses and comparator are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct complication events/denominators, effects/CIs, follow-up losses and comparator are unverified."
    },
    {
      "item_id": "N11",
      "question_type": "Evidence condition",
      "question": "At what level is whey-plus-guar material identified?",
      "needed": "Original combination mention, bibliography/identity, composition, duration, comparator and results",
      "role": "Required",
      "role_reason": "This condition connects Original combination mention, bibliography/identity, composition, duration, comparator and results with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original combination mention, bibliography/identity, composition, duration, comparator and results must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Whey-plus-guar bibliography/registration, composition, duration, population and effects are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original key explanation, research description and product information mention whey plus guar, but no separate guar bibliography or evidence entry is present. Exact formulation, duration, sample size, endpoints/effects are unverified; no fictional report is added.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Whey-plus-guar bibliography/registration, composition, duration, population and effects are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Whey-plus-guar bibliography/registration, composition, duration, population and effects are unverified."
    },
    {
      "item_id": "N12",
      "question_type": "Evidence condition",
      "question": "How does MCT plus WPI differ from whey alone?",
      "needed": "Zameer combination components, formulation/dose, comparator/duration and adherence",
      "role": "Required",
      "role_reason": "This condition connects Zameer combination components, formulation/dose, comparator/duration and adherence with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Zameer combination components, formulation/dose, comparator/duration and adherence must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Component amounts/calories, comparator, exposure/duration and isolated contribution are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Zameer's original design is a randomized MCT-plus-WPI crossover trial. It is not whey alone; component amounts/calories, comparator, actual adherence and exact intervention duration are unverified in the current summary.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Component amounts/calories, comparator, exposure/duration and isolated contribution are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Component amounts/calories, comparator, exposure/duration and isolated contribution are unverified."
    },
    {
      "item_id": "N13",
      "question_type": "Evidence condition",
      "question": "What is the scope of null primary 24-hour/daytime iAUC?",
      "needed": "Zameer endpoints/results, original hierarchy, exact effects/intervals and denominators",
      "role": "Required",
      "role_reason": "This condition connects Zameer endpoints/results, original hierarchy, exact effects/intervals and denominators with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Zameer endpoints/results, original hierarchy, exact effects/intervals and denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Original iAUC effects/CIs, units/denominators and registered plans/analysis are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Zameer's endpoint is 24-hour/daytime glucose iAUC, with null primary iAUC results. Exact effects/CIs, P values, units and denominators are unverified. This is not a direct whey-only HbA1c/complication result.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Original iAUC effects/CIs, units/denominators and registered plans/analysis are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Original iAUC effects/CIs, units/denominators and registered plans/analysis are unverified."
    },
    {
      "item_id": "N14",
      "question_type": "Evidence condition",
      "question": "What was the acute 50 g/30-minute-premeal exposure?",
      "needed": "Jakubowicz acute 50 g, 30 minutes before a meal, 180 minutes and actual formulation/control",
      "role": "Required",
      "role_reason": "This condition connects Jakubowicz acute 50 g, 30 minutes before a meal, 180 minutes and actual formulation/control with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Jakubowicz acute 50 g, 30 minutes before a meal, 180 minutes and actual formulation/control must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Formulation/manufacturing, control/meal and actual exposure are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original wording records 50 g used 30 minutes before a meal and a 180-minute glucose response. Manufacturing, formulation, control contents and meal/dose adherence are unverified; these are not long-term whey-only exposure specifications.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Formulation/manufacturing, control/meal and actual exposure are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Formulation/manufacturing, control/meal and actual exposure are unverified."
    },
    {
      "item_id": "N15",
      "question_type": "Evidence condition",
      "question": "What are the original 28% glucose and 105% insulin findings?",
      "needed": "Original response percentages, 180 minutes, scale/model, denominators and intervals",
      "role": "Required",
      "role_reason": "This condition connects Original response percentages, 180 minutes, scale/model, denominators and intervals with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original response percentages, 180 minutes, scale/model, denominators and intervals must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Response definitions, absolute values/denominators, CIs and exact GLP-1 values are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The key report records glucose 28% lower and insulin 105% higher. The original answer/endpoint describes a GLP-1 increase without an exact increase value. Exact absolute values/CIs, denominators and models are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Response definitions, absolute values/denominators, CIs and exact GLP-1 values are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Response definitions, absolute values/denominators, CIs and exact GLP-1 values are unverified."
    },
    {
      "item_id": "N16",
      "question_type": "Evidence condition",
      "question": "Do insulin and GLP-1 answer the long-term clinical question?",
      "needed": "Mechanistic measures versus separate direct HbA1c, complication and medication outcomes",
      "role": "Required",
      "role_reason": "This condition connects Mechanistic measures versus separate direct HbA1c, complication and medication outcomes with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Mechanistic measures versus separate direct HbA1c, complication and medication outcomes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Links between mechanisms and direct long-term outcomes, mediation and clinical analyses are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original counterpoint/synthesis says higher insulin/GLP-1 are mechanistic outcomes and do not guarantee long-term HbA1c, complication or medication-reduction benefit. Direct long-term links and mediation analyses are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Links between mechanisms and direct long-term outcomes, mediation and clinical analyses are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Links between mechanisms and direct long-term outcomes, mediation and clinical analyses are unverified."
    },
    {
      "item_id": "N17",
      "question_type": "Evidence condition",
      "question": "What is the scope of the 15.6 g protein drink and 7-day study?",
      "needed": "Smith's 7 days, premeal drink, original 15.6 g, product/control and actual exposure",
      "role": "Required",
      "role_reason": "This condition connects Smith's 7 days, premeal drink, original 15.6 g, product/control and actual exposure with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Smith's 7 days, premeal drink, original 15.6 g, product/control and actual exposure must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Product composition, net content, actual adherence and identical long-term exposure are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The research description records a premeal 15.6 g protein drink and Smith's citation describes a 7-day free-living drink study. Exact whey-product composition, actual intake and identical long-term exposure are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Product composition, net content, actual adherence and identical long-term exposure are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Product composition, net content, actual adherence and identical long-term exposure are unverified."
    },
    {
      "item_id": "N18",
      "question_type": "Evidence condition",
      "question": "What does iAUC 1.6±0.6 versus 2.1±0.9 describe?",
      "needed": "Original iAUC values, P=.003, units/time, meaning of ± and denominator/model",
      "role": "Required",
      "role_reason": "This condition connects Original iAUC values, P=.003, units/time, meaning of ± and denominator/model with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original iAUC values, P=.003, units/time, meaning of ± and denominator/model must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: iAUC units/time, the meaning of ±, denominators/models and CIs are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Smith's result is iAUC 1.6±0.6 versus 2.1±0.9, P=.003. Exact iAUC units/time, the meaning of ±, model, exact denominator and intervals are unverified in the stored summary.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "iAUC units/time, the meaning of ±, denominators/models and CIs are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "iAUC units/time, the meaning of ±, denominators/models and CIs are unverified."
    },
    {
      "item_id": "N19",
      "question_type": "Evidence condition",
      "question": "What does approximately 100 kcal versus 34 kcal limit?",
      "needed": "Smith drink calories, calorie imbalance, control composition, meals and other nutrients",
      "role": "Required",
      "role_reason": "This condition connects Smith drink calories, calorie imbalance, control composition, meals and other nutrients with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Smith drink calories, calorie imbalance, control composition, meals and other nutrients must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Composition, meal/total-intake changes and between-condition nutrient contributions are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original explanation records approximately 100 kcal for whey drink and approximately 34 kcal for control, with a non-isocaloric comparison. Product/meal composition beyond protein, total-intake changes and isolated whey contribution are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Composition, meal/total-intake changes and between-condition nutrient contributions are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Composition, meal/total-intake changes and between-condition nutrient contributions are unverified."
    },
    {
      "item_id": "N20",
      "question_type": "Evidence condition",
      "question": "What is known about Smith's registered/published primary mismatch?",
      "needed": "Original hierarchy mismatch, ISRCTN and registered/protocol/published endpoints",
      "role": "Required",
      "role_reason": "This condition connects Original hierarchy mismatch, ISRCTN and registered/protocol/published endpoints with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original hierarchy mismatch, ISRCTN and registered/protocol/published endpoints must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registered/published primary names, analysis/times and registration chronology/amendments are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R02"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original answer, explanation and citation wording record a difference between the registered primary outcome and the published primary outcome. Smith's evidence registration field is ISRCTN17563146. Exact endpoint names/times, amendments and chronology are unverified; registration was not newly read.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Registered/published primary names, analysis/times and registration chronology/amendments are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registered/published primary names, analysis/times and registration chronology/amendments are unverified."
    },
    {
      "item_id": "N21",
      "question_type": "Evidence condition",
      "question": "How are long-term whey-only controls and shared treatment established?",
      "needed": "Long-term whey-only controls, calories/contact, meals/lifestyle/medication and rescue treatment",
      "role": "Required",
      "role_reason": "This condition connects Long-term whey-only controls, calories/contact, meals/lifestyle/medication and rescue treatment with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Long-term whey-only controls, calories/contact, meals/lifestyle/medication and rescue treatment must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term whey-only controls/shared care, meal/medication changes and contact are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The preserved population/exposure summary says control drink. Long-term whey-only control calories/composition, meal/lifestyle management, maintained/changed medication, contact and adherence are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term whey-only controls/shared care, meal/medication changes and contact are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term whey-only controls/shared care, meal/medication changes and contact are unverified."
    },
    {
      "item_id": "N22",
      "question_type": "Evidence condition",
      "question": "What stages do 15, 18 and nonnumeric sample wording represent?",
      "needed": "Original samples, allocation/completion/analysis, crossover/endpoint-specific counts and missing data",
      "role": "Required",
      "role_reason": "This condition connects Original samples, allocation/completion/analysis, crossover/endpoint-specific counts and missing data with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original samples, allocation/completion/analysis, crossover/endpoint-specific counts and missing data must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation/completion, endpoint/crossover denominators and missing data/attrition are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original sample wording is 15 adults with type 2 diabetes for Jakubowicz, 18 participants for Smith, and adults with type 2 diabetes for Zameer. Arm-specific allocation/completion/analysis, crossover/endpoint denominators and attrition are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Allocation/completion, endpoint/crossover denominators and missing data/attrition are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation/completion, endpoint/crossover denominators and missing data/attrition are unverified."
    },
    {
      "item_id": "N23",
      "question_type": "Evidence condition",
      "question": "What are crossover sequence, carryover, period effects and analysis?",
      "needed": "Acute/7-day/MCT crossover, sequence/washout and within-person repeated analysis",
      "role": "Required",
      "role_reason": "This condition connects Acute/7-day/MCT crossover, sequence/washout and within-person repeated analysis with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Acute/7-day/MCT crossover, sequence/washout and within-person repeated analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Allocation/concealment, sequence/washout, carryover/period effects and repeated analysis are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Jakubowicz is an acute randomized crossover trial, Smith a 7-day free-living crossover trial and Zameer a randomized MCT-plus-WPI crossover trial. Actual sequence/concealment, washout, carryover/period effects and within-person analyses are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Allocation/concealment, sequence/washout, carryover/period effects and repeated analysis are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Allocation/concealment, sequence/washout, carryover/period effects and repeated analysis are unverified."
    },
    {
      "item_id": "N24",
      "question_type": "Evidence condition",
      "question": "How do glucose, hormone and long-term outcome measurements differ?",
      "needed": "Outcome-specific devices, units/times, blinding, collection/adjudication and repeats",
      "role": "Required",
      "role_reason": "This condition connects Outcome-specific devices, units/times, blinding, collection/adjudication and repeats with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Outcome-specific devices, units/times, blinding, collection/adjudication and repeats must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Measurement/calculation, blinding and long-term measurement/adjudication are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original measures are 180-minute glucose/hormones, postprandial iAUC/time above range and 24-hour/daytime iAUC. Devices, measurement/calculation, assessor/analyst knowledge and long-term HbA1c/complication collection methods are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Measurement/calculation, blinding and long-term measurement/adjudication are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Measurement/calculation, blinding and long-term measurement/adjudication are unverified."
    },
    {
      "item_id": "N25",
      "question_type": "Evidence condition",
      "question": "How do shared medication/meals connect with long-term analysis?",
      "needed": "Medication, meals/total intake, changes, adherence and comparator/analysis",
      "role": "Required",
      "role_reason": "This condition connects Medication, meals/total intake, changes, adherence and comparator/analysis with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Medication, meals/total intake, changes, adherence and comparator/analysis must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Medication/meals, changes/adherence and long-term analysis are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original context concerns non-insulin-treated adults and premeal drinks. Actual medication types/doses, meals/total intake, arm-specific changes and their treatment in long-term HbA1c/event analysis are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Medication/meals, changes/adherence and long-term analysis are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Medication/meals, changes/adherence and long-term analysis are unverified."
    },
    {
      "item_id": "N26",
      "question_type": "Evidence condition",
      "question": "Are long-term target effects, baseline and missing data known?",
      "needed": "ITT/PP, baseline/covariates, missing data/attrition, adjustment, repeats and sensitivity",
      "role": "Required",
      "role_reason": "This condition connects ITT/PP, baseline/covariates, missing data/attrition, adjustment, repeats and sensitivity with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for ITT/PP, baseline/covariates, missing data/attrition, adjustment, repeats and sensitivity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term baseline/models, ITT/PP, adjustment and missing-data/sensitivity analyses are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Selected long-term whey-only baseline HbA1c/risk, ITT/PP, missing data/attrition, adjustment and sensitivity analyses are unverified. Short-term/combination iAUC values do not supply that target effect.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term baseline/models, ITT/PP, adjustment and missing-data/sensitivity analyses are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term baseline/models, ITT/PP, adjustment and missing-data/sensitivity analyses are unverified."
    },
    {
      "item_id": "N27",
      "question_type": "Evidence condition",
      "question": "What are actual long-term whey exposure, discontinuation and adherence?",
      "needed": "Product/dose, actual intake, discontinuation, tolerability, follow-up and exposure models",
      "role": "Required",
      "role_reason": "This condition connects Product/dose, actual intake, discontinuation, tolerability, follow-up and exposure models with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Product/dose, actual intake, discontinuation, tolerability, follow-up and exposure models must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term actual intake, discontinuation/maintenance and exposure/outcome links are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Selected long-term whey-only actual intake, maintenance/discontinuation, adherence and links to outcome analysis are unverified. Short original exposure specifications are not long-term implementation data.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term actual intake, discontinuation/maintenance and exposure/outcome links are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term actual intake, discontinuation/maintenance and exposure/outcome links are unverified."
    },
    {
      "item_id": "N28",
      "question_type": "Evidence condition",
      "question": "What intervals and plans exist for long-term HbA1c or complications?",
      "needed": "Direct effects/CIs, prespecified plans/power, importance and events/denominators",
      "role": "Required",
      "role_reason": "This condition connects Direct effects/CIs, prespecified plans/power, importance and events/denominators with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Direct effects/CIs, prespecified plans/power, importance and events/denominators must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Long-term effects/intervals, prespecified plans/power and importance are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original parent describes small-sample, surrogate, combination and hierarchy limitations. Long-term whey-only HbA1c/complication effects/CIs, power plans and clinical importance are unverified. Parent precision is unrecorded.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Long-term effects/intervals, prespecified plans/power and importance are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Long-term effects/intervals, prespecified plans/power and importance are unverified."
    },
    {
      "item_id": "N29",
      "question_type": "Evidence condition",
      "question": "How are shared reports, populations and outcomes linked?",
      "needed": "Report/registration/cohort, crossover periods, glucose/hormones and combination/whey-only relationships",
      "role": "Required",
      "role_reason": "This condition connects Report/registration/cohort, crossover periods, glucose/hormones and combination/whey-only relationships with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Report/registration/cohort, crossover periods, glucose/hormones and combination/whey-only relationships must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Related reports/cohorts, unique-trial/participant counts and outcome-specific relationships are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Link Jakubowicz glucose/insulin/GLP-1, Smith short-term glucose metrics and Zameer combination iAUC by report. Related-report/cohort overlap and outcome-specific sample relationships are unverified. The guar mention is not added as a fictional report.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Related reports/cohorts, unique-trial/participant counts and outcome-specific relationships are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Related reports/cohorts, unique-trial/participant counts and outcome-specific relationships are unverified."
    },
    {
      "item_id": "N30",
      "question_type": "Evidence condition",
      "question": "How much direct replication of the same long-term whey-only question is preserved?",
      "needed": "Whey formulation/alone, population, duration, comparator, HbA1c/complications and identity",
      "role": "Required",
      "role_reason": "This condition connects Whey formulation/alone, population, duration, comparator, HbA1c/complications and identity with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Whey formulation/alone, population, duration, comparator, HbA1c/complications and identity must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Direct material for the same long-term whey-only question, conditions/identities and independence are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The original counterview describes supporting postprandial direction in different short designs and consistent mechanisms. Direct replication material for selected long-term whey-only HbA1c/complications is unverified within preserved scope. This is not expanded into absence of all human research.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Direct material for the same long-term whey-only question, conditions/identities and independence are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Direct material for the same long-term whey-only question, conditions/identities and independence are unverified."
    },
    {
      "item_id": "N31",
      "question_type": "Evidence condition",
      "question": "Are NCT/ISRCTN identifiers separate from actual registration content?",
      "needed": "NCT01571622, ISRCTN17563146, NCT04905589 and content/dates/hierarchy",
      "role": "Required",
      "role_reason": "This condition connects NCT01571622, ISRCTN17563146, NCT04905589 and content/dates/hierarchy with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for NCT01571622, ISRCTN17563146, NCT04905589 and content/dates/hierarchy must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Registry content/dates, timing relative to recruitment, endpoints/analysis and amendments are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence registration values are NCT01571622, ISRCTN17563146 and NCT04905589. Actual registry content, dates, endpoints/analysis and amendments were not read in this work; only identifiers are preserved.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Registry content/dates, timing relative to recruitment, endpoints/analysis and amendments are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Registry content/dates, timing relative to recruitment, endpoints/analysis and amendments are unverified."
    },
    {
      "item_id": "N32",
      "question_type": "Evidence condition",
      "question": "At what level is industry/product involvement known?",
      "needed": "Original ministry/Milk Council, Smith product/industry/investigator involvement and Zameer mixed support",
      "role": "Required",
      "role_reason": "This condition connects Original ministry/Milk Council, Smith product/industry/investigator involvement and Zameer mixed support with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original ministry/Milk Council, Smith product/industry/investigator involvement and Zameer mixed support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Support/COI details, roles, analysis involvement and related-study independence are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original wording records health-ministry/Milk Council support for Jakubowicz, product/industry support and investigator involvement for Smith, and mixed academic/product-related support for Zameer. Detailed support/COI, design/analysis roles and independence are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Support/COI details, roles, analysis involvement and related-study independence are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Support/COI details, roles, analysis involvement and related-study independence are unverified."
    },
    {
      "item_id": "N33",
      "question_type": "Evidence condition",
      "question": "Which material was actually read for this table?",
      "needed": "Complete stored summary versus external abstracts, full texts, registration, plans and support",
      "role": "Required",
      "role_reason": "This condition connects Complete stored summary versus external abstracts, full texts, registration, plans and support with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Complete stored summary versus external abstracts, full texts, registration, plans and support must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: External material is unread; access failure or unavailability has not been established either. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The complete stored parent summary is read for production and preserved unchanged. Bibliographic/report summaries are read as summaries; external abstracts, full texts, registration/plans and support material are unread, with no external access attempts.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "External material is unread; access failure or unavailability has not been established either.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "External material is unread; access failure or unavailability has not been established either."
    },
    {
      "item_id": "N34",
      "question_type": "Evidence condition",
      "question": "Are original evidence date, production and current review separate?",
      "needed": "Original date, empty corrections/deliberation and historical cross-check wording",
      "role": "Required",
      "role_reason": "This condition connects Original date, empty corrections/deliberation and historical cross-check wording with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Original date, empty corrections/deliberation and historical cross-check wording must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Current content-review date and new clinical-verification date are unrecorded. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original evidence date is 2026-09-07, corrections are an empty list and deliberation an empty string. Historical parent cross-check wording does not establish completed review in this work.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Current content-review date and new clinical-verification date are unrecorded.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Current content-review date and new clinical-verification date are unrecorded."
    },
    {
      "item_id": "N35",
      "question_type": "Evidence condition",
      "question": "Are selected long-term wording and original parent English preserved together?",
      "needed": "Long-term claim/notes in both languages versus acute/combination/long-term boundaries",
      "role": "Required",
      "role_reason": "This condition connects Long-term claim/notes in both languages versus acute/combination/long-term boundaries with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Long-term claim/notes in both languages versus acute/combination/long-term boundaries must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Detailed original-paper, Korean/English translation and correction comparisons are unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "The selected English claim is Long-term whey-only HbA1c or complication benefit; its note says longer combinations cannot isolate whey. Original parent English key/summary wording separates acute whey, longer combinations and medication-replacement boundaries.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Detailed original-paper, Korean/English translation and correction comparisons are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Detailed original-paper, Korean/English translation and correction comparisons are unverified."
    },
    {
      "item_id": "N36",
      "question_type": "Evidence condition",
      "question": "How are parent axes and absent subclaim values retained?",
      "needed": "Parent axes and unrecorded precision versus absent selected score/status/axes",
      "role": "Required",
      "role_reason": "This condition connects Parent axes and unrecorded precision versus absent selected score/status/axes with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Parent axes and unrecorded precision versus absent selected score/status/axes must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Subclaim score/status/axes fields are absent; long-term precision is unverified. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Parent axes are B/S/R1/I0/E+/B2 with unrecorded precision. Original special-condition flags are false, derived grade is C and override reasons are empty. Separate selected-subclaim score, status and axes are absent.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Subclaim score/status/axes fields are absent; long-term precision is unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Subclaim score/status/axes fields are absent; long-term precision is unverified."
    },
    {
      "item_id": "N37",
      "question_type": "Evidence condition",
      "question": "Are allergy/hypoglycemia cautions actual event data?",
      "needed": "Harm definitions, original allergy/medication cautions, collection/assessment and event tables",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Harm definitions, original allergy/medication cautions, collection/assessment and event tables with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Harm definitions, original allergy/medication cautions, collection/assessment and event tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm definitions/collection, assessors and actual event tables are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original parent safety is Caution; its detail concerns milk-protein allergy and potentially hypoglycemia-causing medication. Actual allergy/hypoglycemia event counts and collection/assessment methods are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm definitions/collection, assessors and actual event tables are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm definitions/collection, assessors and actual event tables are unverified."
    },
    {
      "item_id": "N38",
      "question_type": "Evidence condition",
      "question": "What are exposure, symptoms/discontinuation and long-term harm follow-up?",
      "needed": "Actual intake/meals, medication, event/recovery times and short-/long-term follow-up",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Actual intake/meals, medication, event/recovery times and short-/long-term follow-up with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Actual intake/meals, medication, event/recovery times and short-/long-term follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm onset/recovery, discontinuation and long-term/post-intervention follow-up are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original material concerns acute/7-day/combination glucose contexts. Actual harm onset/recovery, discontinuation and follow-up after long-term whey-only exposure are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm onset/recovery, discontinuation and long-term/post-intervention follow-up are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm onset/recovery, discontinuation and long-term/post-intervention follow-up are unverified."
    },
    {
      "item_id": "N39",
      "question_type": "Evidence condition",
      "question": "Which comparator defines whey-only or combination harm comparisons?",
      "needed": "Arm-specific collection/timing, control drinks/calories, meals/medication and event tables",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Arm-specific collection/timing, control drinks/calories, meals/medication and event tables with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Arm-specific collection/timing, control drinks/calories, meals/medication and event tables must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm comparators, identical collection/follow-up and original comparative outcomes are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original control-drink, calorie-imbalance and combination conditions are recorded. Identical harm collection/windows across conditions, direct comparison tables and long-term whey-only control harms are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm comparators, identical collection/follow-up and original comparative outcomes are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm comparators, identical collection/follow-up and original comparative outcomes are unverified."
    },
    {
      "item_id": "N40",
      "question_type": "Evidence condition",
      "question": "Are harm counts and actual exposure/observation denominators available?",
      "needed": "Exposure/observation/arm denominators, harm counts, discontinuation and duration",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Exposure/observation/arm denominators, harm counts, discontinuation and duration with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Exposure/observation/arm denominators, harm counts, discontinuation and duration must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Harm counts, actual exposure/observation denominators and duration are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original sample wording exists, but direct allergy/hypoglycemia harm counts, actual exposure/observation denominators, discontinuation and long-term follow-up are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Harm counts, actual exposure/observation denominators and duration are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Harm counts, actual exposure/observation denominators and duration are unverified."
    },
    {
      "item_id": "N41",
      "question_type": "Evidence condition",
      "question": "Are medication, meals, allergy and combination components distinguished?",
      "needed": "Shared medication/meals, baseline risk, whey/guar/MCT and event chronology",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Shared medication/meals, baseline risk, whey/guar/MCT and event chronology with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Shared medication/meals, baseline risk, whey/guar/MCT and event chronology must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Actual events, shared factors, baseline risks and causal assessments are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Original safety wording mentions milk-protein allergy and potentially hypoglycemia-causing medication. Actual events, meals/medication/baseline risk, combination-component contributions and causal assessment are unverified.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Actual events, shared factors, baseline risks and causal assessments are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Actual events, shared factors, baseline risks and causal assessments are unverified."
    },
    {
      "item_id": "N42",
      "question_type": "Evidence condition",
      "question": "What are discontinuation/attrition and loss of harm reporting?",
      "needed": "Discomfort/discontinuation reasons, arm-specific attrition, missing/selective harm reporting and later follow-up",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Discomfort/discontinuation reasons, arm-specific attrition, missing/selective harm reporting and later follow-up with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Discomfort/discontinuation reasons, arm-specific attrition, missing/selective harm reporting and later follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Discontinuation/attrition, missing/selective harm reporting and later follow-up are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Arm-specific discontinuation/attrition, harm-data losses, selective reporting and long-term/later follow-up are unverified in the original summary. Not reading the original paper does not establish that the paper failed to report these items.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Discontinuation/attrition, missing/selective harm reporting and later follow-up are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Discontinuation/attrition, missing/selective harm reporting and later follow-up are unverified."
    },
    {
      "item_id": "N43",
      "question_type": "Evidence condition",
      "question": "How much is known about independent, vulnerable-population or long-term whey-only harms?",
      "needed": "Same-formulation/whey-only harms, independent reports, treatment/disease populations and follow-up",
      "role": "Supplementary; required for extending long-term safety conclusions",
      "role_reason": "This condition connects Same-formulation/whey-only harms, independent reports, treatment/disease populations and follow-up with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Same-formulation/whey-only harms, independent reports, treatment/disease populations and follow-up must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Independent harms, vulnerable/treatment populations and long-term whey-only follow-up are unverified. This records needed materials; no new research was executed.",
      "current_reports": [
        "R01",
        "R02",
        "R03"
      ],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Short glucose/hormone and combination iAUC material within preserved scope is not direct verification of long-term whey-only safety. Independent harms, other treatment/disease populations and long-term/later follow-up are unverified.",
      "condition_status": "Unverified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Independent harms, vulnerable/treatment populations and long-term whey-only follow-up are unverified.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Independent harms, vulnerable/treatment populations and long-term whey-only follow-up are unverified."
    },
    {
      "item_id": "N44",
      "question_type": "Evidence condition",
      "question": "Are material versions, application and review status separate?",
      "needed": "Preserved methodological material, condition versions and production/application records",
      "role": "Required",
      "role_reason": "This condition connects Preserved methodological material, condition versions and production/application records with long-term whey alone, separate direct HbA1c and complication outcomes, populations and denominators, duration, actual comparators and exposure, short-term/combination background, support and harms.",
      "application_exception": "Preserve original subclaim ?, the note that longer combination trials cannot isolate whey, and absent score, status and axes. Acute/several-day glucose and hormones, calorie imbalance and combination iAUC are not direct long-term whey-only HbA1c/complication results. Unverified does not mean no effect, established safety or absence of all research; create no new effects, CIs, totals, grades, independence certification, dosing, medication reduction/replacement or treatment guidance.",
      "criterion": "Material for Preserved methodological material, condition versions and production/application records must be linked to the selected subclaim, parent context, same report/trial, outcome units, times, actual comparator and denominators, distinguishing unread external material.",
      "basis": "Preserved C/E/H application conditions concerning questions, populations, interventions, comparators, reports versus studies, endpoints, denominators and harms were referenced.",
      "condition_origin": "Internally applied conditions preserved for the existing subclaim. They do not establish preregistration, official-tool certification or completed content review.",
      "proposed_research": "Material needed: Completed content review or new official-method/external clinical certification is not established. This records needed materials; no new research was executed.",
      "current_reports": [],
      "existence": "Display information in the original parent stored summary is preserved. Public availability, acquisition and actual reading of detailed external material are separately unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "observation": "Preserved methodological material, condition versions and production/application records are distinguished. Review of existing content and claim boundaries remains incomplete; this is not completed clinical review or official methodological certification.",
      "condition_status": "Partly verified",
      "status_reason": "The selected claim, parent material and reports are distinguished and transferred from the stored summary. Detailed original material is unverified and review of existing content remains incomplete. This does not establish completed clinical review or certification.",
      "missingness": "Completed content review or new official-method/external clinical certification is not established.",
      "uncertainty": "External original material is unread and review of existing content remains incomplete. Original grades, scores, axes, historical verification and independence statements are not treated as new verdicts or certification.",
      "review_date": null,
      "reading_status": "Full text not read · Stored summary read",
      "additional_material": "Completed content review or new official-method/external clinical certification is not established."
    }
  ],
  "reports": [
    {
      "report_id": "R01",
      "title": "Jakubowicz D, Froy O, Ahrén B, et al. Incretin, insulinotropic and glucose-lowering effects of whey protein pre-load in type 2 diabetes: a randomised clinical trial. Diabetologia. 2014;57:1807-1811. PMID: 25005331. DOI: 10.1007/s00125-014-3305-x.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/25005331/",
      "report_type": "Acute randomized crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "Acute whey-only report; independent replication unverified",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "Glucose response 28% lower; insulin 105% higher",
      "result_level": "Acute background for the selected long-term question. Preserve original 15 adults with type 2 diabetes, 50 g, 30 minutes before a meal, 180-minute glucose response 28% lower/insulin 105% higher and a GLP-1 increase. Exact GLP-1 values, direct effects/CIs and denominators are unverified; this is not a direct long-term whey-only HbA1c/complication result.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Analysis plan and original tables",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Intervention and harms",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Support and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 25005331, DOI 10.1007/s00125-014-3305-x and PMCID unrecorded. Distinguish evidence registration field NCT01571622 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/25005331/"
        }
      ]
    },
    {
      "report_id": "R02",
      "title": "Smith K, Taylor GS, Allerton DM, et al. Thrice daily consumption of a novel, premeal shot containing a low dose of whey protein increases time in euglycemia during 7 days of free-living in individuals with type 2 diabetes. BMJ Open Diabetes Res Care. 2022;10:e002820. PMID: 35618446. PMCID: PMC9137348. DOI: 10.1136/bmjdrc-2022-002820.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/35618446/",
      "report_type": "Seven-day free-living crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "7-day non-isocaloric whey-drink report; independent replication unverified",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "iAUC 1.6±0.6 versus 2.1±0.9, P=.003",
      "result_level": "Separate 7-day free-living background for the selected long-term question. Distinguish 18 participants, a premeal 15.6 g protein drink and iAUC 1.6±0.6 versus 2.1±0.9/P=.003 from approximately 100 kcal versus 34 kcal calorie imbalance and the original registered/published primary-outcome mismatch. Units, the meaning of ±, CIs, time-metric values and exact mismatched endpoints are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Analysis plan and original tables",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Intervention and harms",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Support and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 35618446, DOI 10.1136/bmjdrc-2022-002820 and PMCID PMC9137348. Distinguish evidence registration field ISRCTN17563146 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/35618446/"
        }
      ]
    },
    {
      "report_id": "R03",
      "title": "Zameer R, et al. Effect of medium-chain triglycerides and whey protein isolate preloads on glycaemia in type 2 diabetes: a randomized crossover study. Am J Clin Nutr. 2025. PMID: 39732398. PMCID: PMC11863336. DOI: 10.1016/j.ajcnut.2024.12.022.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/39732398/",
      "report_type": "Randomized MCT-plus-WPI crossover trial",
      "existence": "Report linked in the original parent stored summary evidence/citation lists. External public availability, access and current acquisition of the original are unverified.",
      "acquired_read": "Stored summary read; external abstracts, full texts, registration, protocols, SAPs and support disclosures unread",
      "study_family": "MCT-plus-WPI combination report; not whey alone",
      "independent_replication": "Parent 2997 and both subclaim sheets share the context of the same three reports. Acute/7-day whey and MCT-plus-WPI combinations are not certified as independent replication of the same intervention. Reports, sheets, crossover periods, repeated measurements and subgroups are not summed into new trials or participants; unique-trial/participant totals, cohort relationships and independence are unverified.",
      "observed_result": "Primary iAUC outcomes were null",
      "result_level": "Background of null primary 24-hour/daytime iAUC with combined MCT plus WPI. Do not extend this into direct null long-term whey-only HbA1c/complication results, zero effect or equivalence. Exact sample size, intervention duration, effects/CIs, P values and denominators are unverified.",
      "source_evidence_date": "2026-09-07",
      "materials": [
        {
          "material_type": "Stored existing review summary",
          "public_status": "Preserved copy of the complete parent-verdict stored summary",
          "access_status": "Stored summary",
          "acquired": true,
          "actually_read": "Summary read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External abstract",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "External full text",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Registration material",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Protocol",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Analysis plan and original tables",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Intervention and harms",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        },
        {
          "material_type": "Support and interests",
          "public_status": "Original bibliographic link or needed material; external public availability/access status unverified",
          "access_status": "Unread; access not attempted",
          "acquired": false,
          "actually_read": "Not read",
          "as_of": "2026-09-07",
          "qualification": "Preserve the original PubMed URL, PMID 39732398, DOI 10.1016/j.ajcnut.2024.12.022 and PMCID PMC11863336. Distinguish evidence registration field NCT04905589 from unrecorded registration wording in the citation. No new URL, prospective registration status or actual reading is inferred from identifiers."
        }
      ],
      "links": [
        {
          "label": "PubMed",
          "url": "https://pubmed.ncbi.nlm.nih.gov/39732398/"
        }
      ]
    }
  ],
  "method_sources": [
    {
      "id": "M03",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-03",
      "section": "§3.1, §3.2.1–3.2.3, MECIR C5/C7/C13",
      "official_principle": "Clearly record the question, eligibility conditions and reasons for changes, and distinguish variations in interventions.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M04",
      "version": "Cochrane Handbook 6.5.1 (2025), chapter updated 2025-03",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-04",
      "section": "§4.5, §4.6.1–4.6.3, MECIR C42",
      "official_principle": "Distinguish studies from reports and link them; do not omit a study solely because results are unreported.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M08",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-08",
      "section": "§8.1–8.2.3, Table 8.2.a",
      "official_principle": "Define the outcome and effect of interest, then examine randomization, deviations, missing data, measurement and selective reporting.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M15",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2023-08",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-15",
      "section": "§15.2.4, §15.3.1–15.3.3",
      "official_principle": "Distinguish effect estimates, intervals, importance and applicability. Sample size alone does not determine precision.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    },
    {
      "id": "M19",
      "version": "Cochrane Handbook 6.5 (2024), chapter updated 2019-10",
      "url": "https://www.cochrane.org/authors/handbooks-and-manuals/handbook/current/chapter-19",
      "section": "§19.1.2, §19.2.1–19.2.4",
      "official_principle": "Harm questions may require different designs, populations and follow-up from efficacy questions. Case reports do not establish incidence rates.",
      "review_level": "Existing methodological links were reused for production. External originals were not reread and methodological content was not reassessed."
    }
  ],
  "status_dictionary": {
    "Met": "The original content has been reviewed as meeting the conditions. This status is not used in this preparation.",
    "Partly verified": "Some information in the stored summary was linked during preparation; clinical verification or review is not complete.",
    "Unverified": "Required direct values, definitions or materials have not been established within the current storage and reading scope. This does not mean zero effect, no papers or failed access.",
    "Review incomplete": "Awaiting user review, or actual review remains incomplete.",
    "Not reported": "Used only when original materials were actually read and the outcome was judged unreported. Not used for external materials unread in this work.",
    "Inaccessible": "Used only when an actual access attempt has a recorded failure. Not used for access that was not attempted in this work.",
    "Insufficient evidence for the conditions": "Indicates insufficient direct materials for the relevant scope or conditions; it is not a new grade.",
    "Not applicable": "Used when the reason it does not apply to the original question is stated.",
    "Conflicting data": "Retains the scope of conflicting statements in original materials; it is not an arbitrary reassessment."
  },
  "study_overlap": {
    "state": "Unverified",
    "unique_trial_count": null,
    "unique_participant_count": null,
    "reason": "Parent 2997 and the short-/long-term subclaim sheets share the context of the same three reports. Distinguish R01 acute glucose/hormones, R02 7-day glucose metrics and R03 MCT-plus-WPI iAUC by report. The unidentified guar mention is not added as a new report. Crossover periods, outcomes, sheets and reports are not summed into new unique-trial, participant or independent-replication totals; cohort relationships, confirmed totals and independence are unverified."
  },
  "history": [
    {
      "date": "2026-10-16",
      "kind": "Separation of public-facing pages and materials",
      "view_version": "1.0",
      "change": "A public view and materials were prepared from the existing 44 items. No new clinical search, verification-status change or scoring was performed."
    }
  ],
  "language": "en",
  "translation_date": "2026-10-16"
}